Hub : Genes

Dgka

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb mRNA stability Dgka 0.33 0.22 9.3e-05 0.2 0.19 0.18 0.18 1.4e-05 3.2e-05 4.1e-05 4.5e-05
2 Liver gene expression Dgka 0.31 0.14 0.0e+00 0.24 0.25 0.25 0.26 8.6e-27 6.0e-28 5.5e-28 4.4e-28
3 Adipose gene expression Dgka 0.24 0.12 0.0e+00 0.19 0.18 0.17 0.18 1.8e-20 5.9e-20 4.6e-19 5.7e-20
4 IL gene expression Dgka 0.32 0.17 2.4e-04 0.08 0.07 0.07 0.07 4.8e-03 9.5e-03 7.2e-03 1.0e-02
5 Adipose isoform ratio XM_039078319.2 0.09 0.06 3.2e-09 0.07 0.06 0.06 0.07 2.2e-08 3.7e-07 9.7e-08 5.8e-08
6 Liver mRNA stability Dgka 0.1 0.07 9.2e-10 0.08 0.07 0.07 0.08 3.2e-09 7.1e-08 1.8e-08 7.4e-09
7 PL mRNA stability Dgka 0.05 0.04 5.6e-04 0.03 0.02 0.03 0.03 1.3e-04 9.5e-04 7.1e-04 1.9e-04
8 pVTA gene expression Dgka 0.06 0.04 6.3e-05 0.06 0.05 0.05 0.05 1.2e-05 5.0e-05 1.3e-04 8.1e-05
9 RMTg isoform ratio XM_039078319.2 0.19 0.12 3.0e-03 0.09 0.08 0.08 0.09 1.9e-03 3.2e-03 3.2e-03 2.8e-03
10 Brain gene expression Dgka 0.06 0.04 7.8e-04 0.02 0.02 0.02 0.03 2.8e-03 3.3e-03 4.4e-03 2.1e-03
11 Adipose mRNA stability Dgka 0.14 0.09 1.2e-13 0.09 0.1 0.1 0.1 7.7e-10 2.5e-11 9.7e-12 3.0e-11
12 BLA gene expression Dgka 0.11 0.07 5.4e-06 0.08 0.11 0.12 0.11 4.6e-05 2.0e-06 6.3e-07 2.4e-06
13 PL gene expression Dgka 0.14 0.08 3.7e-15 0.11 0.14 0.11 0.13 8.3e-12 1.4e-14 2.0e-12 6.1e-14
14 IC gene expression Dgka 0.16 0.09 1.1e-06 0.16 0.15 0.14 0.15 2.0e-07 5.8e-07 2.0e-06 6.2e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.81.46.0-0.9-0.1-0.80.60.6-0.61.0-0.5-1.01.1-1.61.42.02.4
Area under the delay curve0.00.00.20.40.00.40.00.0-0.0-0.00.3-0.10.10.10.2-0.10.2
BMI with tail6.923.730.05.45.55.4-5.3-5.35.35.35.3-5.25.24.2-4.4-3.4-1.1
BMI without tail1.95.77.42.62.72.6-2.6-2.62.62.62.7-2.42.42.1-2.2-1.8-0.7
Body weight1.25.27.82.82.32.7-2.4-2.42.42.12.8-1.91.92.3-2.3-2.1-1.1
Weight adjusted by age0.00.00.1-0.1-0.1-0.10.00.0-0.0-0.30.20.3-0.30.20.0-0.2-0.3
Bone surface2.44.413.7-2.1-0.8-2.11.51.5-1.50.8-1.6-0.91.0-3.02.53.43.7
Bone volume2.23.913.9-1.8-0.5-1.71.31.3-1.31.2-1.4-1.21.3-2.72.33.23.7
Breakpoint value in progressive ratio session0.70.81.1-1.0-1.0-0.91.01.0-1.0-1.0-1.01.1-1.1-0.80.60.50.1
Number of licking bursts2.54.15.32.32.12.3-2.2-2.22.21.52.3-1.61.52.2-2.1-2.0-1.4
Context. condit. distance diff. score0.30.30.50.60.70.6-0.7-0.70.70.40.5-0.60.60.6-0.5-0.4-0.2
Locomotion velocity, session 10.40.42.10.1-0.0-0.00.30.3-0.30.8-0.2-0.60.6-0.60.81.01.4
Locomotion distance, session 10.91.23.3-0.9-0.7-0.91.01.0-1.00.2-1.1-0.10.1-1.41.51.71.8
Locomotion velocity, session 22.63.05.5-1.8-1.4-1.91.71.7-1.7-0.7-1.90.6-0.5-2.22.22.42.1
Locomotion distance, session 23.65.07.1-2.2-2.3-2.22.62.6-2.6-1.5-2.21.5-1.4-2.42.72.52.1
Locomotion velocity, session 33.94.46.2-2.2-2.4-2.22.32.3-2.3-2.3-2.32.5-2.5-1.51.91.30.2
Locomotion distance, session 30.10.10.2-0.2-0.3-0.10.30.3-0.3-0.3-0.20.4-0.50.10.1-0.1-0.2
Stereotopy head waving bouts, day 35.36.28.4-2.9-2.7-2.92.62.6-2.6-2.5-2.72.4-2.4-2.42.52.11.0
Stereotopy head waving duration, day 33.64.36.8-2.6-2.1-2.62.02.0-2.0-2.1-2.51.9-1.8-2.12.01.90.8
Locomotion velocity, session 70.10.20.4-0.4-0.3-0.40.40.4-0.4-0.1-0.60.0-0.0-0.40.60.60.6
Locomotion distance, session 70.30.40.90.60.50.6-0.6-0.60.60.00.5-0.10.01.0-0.8-0.9-0.9
Stereotopy head waving bouts, day 71.51.72.7-1.3-1.2-1.21.41.4-1.4-0.6-1.30.7-0.6-1.61.61.61.4
Stereotopy head waving duration, day 71.51.83.4-1.2-1.2-1.21.41.4-1.4-0.4-1.30.5-0.5-1.71.81.81.7
Locomotion velocity, session 82.22.74.7-1.4-1.6-1.51.81.8-1.8-0.7-1.50.8-0.7-1.92.22.12.0
Locomotion distance, session 80.40.60.9-0.7-0.8-0.70.90.9-0.9-0.8-0.70.6-0.5-0.71.00.80.7
Degree of sensitization distance0.50.60.80.90.90.8-0.8-0.80.80.80.7-0.90.90.5-0.6-0.4-0.0
Degree of sensitization stereotypy0.20.20.90.10.00.10.20.2-0.20.5-0.0-0.40.4-0.40.50.61.0
Conditioned locomotion1.71.93.41.61.11.6-1.4-1.41.40.61.4-0.30.31.8-1.7-1.8-1.7
Cocaine response after cond. corrected2.93.54.62.01.92.0-2.1-2.12.11.11.9-1.21.22.1-2.1-2.0-1.7
Cocaine response after cond. not corrected3.13.75.22.01.92.0-2.2-2.22.21.22.0-1.21.22.2-2.3-2.1-1.8
Cocaine response before conditioning0.60.71.0-1.0-0.9-0.90.90.9-0.9-0.5-0.80.7-0.7-0.90.70.70.6
Saline control response0.71.01.71.20.91.1-1.0-1.01.00.71.3-0.50.51.1-1.1-1.2-0.9
Bone: connectivity density0.50.83.1-0.7-0.1-0.70.50.5-0.50.6-0.4-0.70.7-1.11.01.51.8
Bone: cortical apparent density0.91.32.31.11.41.1-1.2-1.21.21.21.0-1.51.50.7-1.0-0.6-0.0
Bone: cortical area0.71.03.00.00.90.0-0.5-0.50.51.70.1-1.71.7-0.60.31.01.6
Bone: cortical porosity0.20.20.6-0.4-0.0-0.40.20.2-0.20.3-0.3-0.30.4-0.50.40.70.8
Bone: cortical porosity0.30.41.4-0.40.2-0.40.10.1-0.10.6-0.2-0.80.8-0.70.50.91.2
Bone: cortical thickness1.01.74.50.81.60.8-1.3-1.31.32.10.8-2.12.10.2-0.60.20.9
Bone: cortical thickness0.91.01.61.21.01.2-1.1-1.11.10.81.0-0.70.71.0-1.3-1.1-0.7
Bone: cortical tissue density0.60.91.60.91.10.9-1.0-1.01.01.00.8-1.31.30.6-0.8-0.5-0.0
Condit. Reinf. active minus inactive responses1.71.92.8-1.6-1.5-1.61.41.4-1.4-1.7-1.71.4-1.3-1.11.31.10.4
Condit. Reinf. active-inactive response ratio0.20.20.7-0.5-0.3-0.50.20.2-0.2-0.8-0.40.5-0.6-0.00.1-0.0-0.5
Condit. Reinf. active responses3.03.85.1-2.2-2.0-2.22.02.0-2.0-1.9-2.31.5-1.5-1.92.11.91.3
Condit. Reinf. inactive responses2.12.53.5-1.6-1.6-1.61.71.7-1.7-1.0-1.71.0-0.9-1.81.91.81.6
Incentive salience index mean1.51.92.5-1.5-1.4-1.51.51.5-1.5-1.2-1.61.0-0.9-1.31.61.51.1
Condit. Reinf. lever presses0.91.33.5-0.9-0.9-0.91.21.2-1.2-0.1-1.00.2-0.1-1.31.61.61.9
Condit. Reinf. active minus inactive responses1.52.04.1-1.4-1.6-1.41.31.3-1.3-2.0-1.42.0-2.0-0.60.70.2-0.8
Condit. Reinf. active-inactive response ratio0.70.82.6-0.1-0.7-0.10.30.3-0.3-1.4-0.21.4-1.50.7-0.5-1.0-1.6
Condit. Reinf. active responses1.42.03.0-1.7-1.5-1.71.41.4-1.4-1.5-1.51.6-1.5-1.21.20.90.0
Condit. Reinf. inactive responses0.60.81.4-1.2-0.7-1.20.80.8-0.8-0.3-0.90.4-0.3-1.11.01.10.8
Condit. Reinf. lever presses1.82.54.4-1.8-1.8-1.81.61.6-1.6-2.0-1.62.1-2.1-1.31.00.6-0.5
Condit. Reinf. lever reinforcers received0.91.32.1-1.4-1.3-1.41.11.1-1.1-1.4-1.21.4-1.4-0.80.80.5-0.3
Conditioned reinforcement - actives0.00.10.3-0.60.3-0.5-0.2-0.20.20.1-0.1-0.20.20.0-0.00.3-0.1
Conditioned reinforcement - inactives0.40.61.30.31.00.4-1.0-1.01.00.40.7-0.60.60.8-1.1-0.7-0.8
Conditioned locomotion2.33.06.6-2.5-1.5-2.61.51.5-1.5-1.4-2.21.2-1.1-2.01.61.90.8
Patch foraging indifference point 0 sec2.54.79.02.02.61.9-2.3-2.32.33.02.1-2.92.91.2-1.7-0.80.3
Patch foraging indifference point AUC0.50.72.3-0.6-1.0-0.80.80.8-0.8-1.5-0.81.1-1.1-0.50.60.3-0.2
Delay disc. indifference point, 0s delay1.01.12.90.90.90.9-0.6-0.60.61.60.8-1.71.7-0.10.50.61.5
Delay disc. indifference point, 16s delay0.20.20.5-0.5-0.5-0.30.50.5-0.5-0.4-0.50.4-0.4-0.50.70.40.3
Delay disc. indifference point, 2s delay0.20.30.70.80.30.6-0.2-0.20.20.40.5-0.70.8-0.2-0.20.20.8
Delay disc. indifference point, 24s delay0.20.20.70.70.30.8-0.3-0.30.30.50.8-0.40.40.5-0.2-0.5-0.0
Delay disc. indifference point, 4s delay0.60.61.2-0.6-0.7-0.70.80.8-0.8-0.2-0.70.2-0.2-1.01.01.11.1
Delay disc. indifference point, 8s delay0.30.41.00.60.40.8-0.5-0.50.5-0.10.8-0.10.01.0-0.3-0.9-0.8
Indifference point function ln k0.10.10.30.10.50.1-0.5-0.50.50.60.0-0.50.50.2-0.3-0.1-0.1
Indifference point function log k0.10.10.30.10.50.1-0.5-0.50.50.60.0-0.50.50.2-0.3-0.1-0.1
Patch foraging total patch changes 0 sec2.24.28.01.92.51.8-2.2-2.22.22.81.9-2.82.81.2-1.6-0.80.3
Patch foraging total patch changes 12 sec1.92.43.41.71.71.6-1.8-1.81.81.31.9-1.41.41.4-1.5-1.3-0.8
Patch foraging total patch changes 18 sec0.00.00.10.30.10.20.00.0-0.00.20.3-0.20.2-0.0-0.0-0.00.3
Patch foraging total patch changes 24 sec0.20.41.20.60.60.7-0.5-0.50.51.10.7-0.90.90.1-0.3-0.10.5
Patch foraging total patch changes 6 sec1.42.13.81.31.81.2-1.6-1.61.61.91.3-1.91.90.9-1.1-0.50.1
Patch foraging time to switch 0 sec0.10.21.10.10.40.2-0.2-0.20.21.00.5-0.70.7-0.10.20.40.8
Patch foraging water rate 0 sec0.61.32.21.31.11.2-1.2-1.21.20.61.0-0.70.71.4-1.5-1.4-1.2
Patch foraging water rate 12 sec0.81.72.81.41.21.3-1.4-1.41.40.91.2-0.80.81.5-1.7-1.5-1.2
Patch foraging water rate 18 sec1.01.55.40.90.40.9-0.9-0.90.9-0.80.80.6-0.71.5-1.6-2.0-2.3
Patch foraging water rate 24 sec3.54.99.52.41.82.4-2.2-2.22.20.62.2-0.60.52.8-2.9-3.1-2.8
Patch foraging water rate 6 sec0.40.52.2-0.1-0.3-0.2-0.0-0.00.0-1.2-0.30.9-1.00.6-0.8-1.0-1.5
Seeking ratio, delayed vs. immediate footshock1.62.04.3-1.7-1.3-1.81.41.4-1.4-0.9-1.60.9-0.9-2.11.41.51.0
Distance traveled before self-admin1.11.52.0-1.3-1.4-1.21.41.4-1.4-1.4-1.31.3-1.3-1.11.10.80.4
Distance traveled after self-admin0.00.00.00.1-0.10.10.10.1-0.10.10.20.2-0.2-0.10.1-0.1-0.0
Extensor digitorum longus weight5.220.325.44.95.04.9-5.0-5.05.04.15.0-4.14.14.3-4.6-3.9-2.2
Bone: elastic displacement0.00.00.0-0.00.0-0.10.00.0-0.00.2-0.0-0.10.2-0.2-0.00.10.1
Bone: elastic work0.50.71.90.70.90.7-0.7-0.70.71.40.8-1.31.40.1-0.40.00.6
Bone: endosteal estimation0.30.72.20.31.00.3-0.8-0.80.81.30.4-1.51.5-0.1-0.20.30.8
Bone: endosteal perimeter0.61.32.5-1.4-0.8-1.41.01.0-1.0-0.4-1.30.2-0.2-1.51.41.61.4
Epididymis fat weight0.10.41.40.2-0.30.30.00.0-0.0-0.80.30.9-0.90.8-0.5-0.9-1.2
Delta time in closed arm before/after self-admin3.02.84.81.51.51.5-1.9-1.91.90.41.8-0.60.51.8-2.2-2.2-2.2
Delta time in open arm before/after self-admin0.80.81.91.30.81.4-0.7-0.70.71.01.1-0.70.71.1-0.8-0.8-0.2
Diff in mean of infusions in LGA sessions1.51.82.6-1.6-1.5-1.51.41.4-1.4-1.6-1.61.6-1.6-1.01.10.80.0
Delay discount exponential model param0.00.00.1-0.30.1-0.3-0.1-0.10.10.1-0.2-0.00.0-0.0-0.20.1-0.2
Extinction: sum of active levers before priming1.01.12.8-0.9-1.2-0.90.90.9-0.9-1.7-0.91.6-1.7-0.20.4-0.0-0.8
Active lever presses in extinction session 60.20.20.3-0.5-0.5-0.50.50.5-0.5-0.3-0.60.3-0.3-0.40.60.50.4
Bone: final force1.72.88.01.21.91.2-1.4-1.41.42.81.2-2.72.70.3-0.60.31.4
Bone: final moment1.72.77.81.21.91.2-1.4-1.41.42.81.2-2.72.70.3-0.60.31.4
Food consumed during 24 hour testing period0.30.40.60.70.70.7-0.6-0.60.60.70.7-0.70.70.3-0.6-0.4-0.1
Glucose1.32.13.51.81.41.9-1.4-1.41.41.61.8-1.31.31.4-1.4-1.2-0.4
Heart weight0.20.31.2-0.3-0.4-0.40.20.2-0.2-1.1-0.30.8-0.80.0-0.0-0.2-0.7
Delay discount hyperbolic model param0.10.10.3-0.5-0.1-0.50.10.1-0.1-0.2-0.40.4-0.4-0.0-0.10.0-0.4
Intermittent access intake day 1-15 change0.20.40.9-1.0-0.5-0.70.30.3-0.3-0.9-0.50.9-0.9-0.30.10.0-0.7
Intermittent access intake escalation0.10.30.8-0.9-0.4-0.60.20.2-0.2-0.8-0.40.8-0.9-0.20.1-0.1-0.7
Intermittent access intake escalation 20.40.50.9-0.9-0.7-0.70.60.6-0.6-0.9-0.61.0-1.0-0.50.40.2-0.3
Intermitt. access day 1 inactive lever presses0.20.62.3-0.1-0.3-0.1-0.1-0.10.1-1.3-0.21.2-1.20.7-0.4-0.9-1.5
Intermitt. access day 15 inactive lever presses0.40.81.8-0.9-1.0-0.60.90.9-0.9-1.4-0.81.2-1.3-0.10.70.2-0.2
Intermitt. access escalation Index0.20.30.8-0.50.1-0.30.20.2-0.20.5-0.2-0.60.6-0.60.70.80.9
Intermittent access day 1 total infusions0.10.20.50.20.60.2-0.7-0.70.70.20.3-0.50.40.4-0.4-0.2-0.4
Intermittent access day 15 total infusions0.10.10.5-0.70.2-0.4-0.2-0.20.20.1-0.2-0.20.2-0.20.10.40.0
Intermittent access terminal intake (last 3 days)0.20.31.0-1.0-0.1-0.80.20.2-0.20.2-0.5-0.20.2-0.60.60.90.6
Intermittent access total infusions0.10.10.3-0.40.4-0.2-0.4-0.40.40.50.1-0.60.60.0-0.00.30.1
Intermittent access day 1 locomotion0.20.31.00.40.40.3-0.6-0.60.6-0.10.30.1-0.10.7-0.6-0.7-1.0
Intermittent access day 15 total locomotion0.10.20.5-0.7-0.1-0.7-0.0-0.00.0-0.6-0.50.5-0.5-0.1-0.20.0-0.5
Intermittent access total locomotion0.10.10.2-0.4-0.2-0.50.00.0-0.0-0.4-0.20.4-0.4-0.1-0.00.0-0.4
Intermittent access standard deviation0.61.23.1-1.7-0.8-1.70.90.9-0.9-0.8-1.40.6-0.5-1.31.11.30.6
Left kidney weight0.00.10.20.40.10.4-0.2-0.20.2-0.00.20.2-0.20.4-0.2-0.5-0.5
Right kidney weight0.10.41.2-0.3-0.7-0.30.50.5-0.5-1.0-0.51.1-1.1-0.10.3-0.2-0.7
Cocaine induced anxiety1.92.74.7-1.8-1.6-1.81.81.8-1.8-1.0-1.70.9-0.9-2.21.81.91.6
Post-drug Anxiety2.22.46.3-1.5-1.2-1.51.51.5-1.5-0.2-1.40.2-0.1-2.51.72.02.2
Baseline Anxiety0.00.00.00.10.10.1-0.1-0.10.10.20.1-0.20.2-0.1-0.1-0.00.1
Tail length2.710.616.3-3.4-3.8-3.53.53.5-3.5-3.8-3.34.0-4.0-2.42.61.7-0.0
Length with tail1.04.48.6-2.0-2.5-2.12.22.2-2.2-2.8-1.92.9-2.9-1.21.30.6-0.6
Length without tail0.30.91.21.10.91.1-1.0-1.01.00.61.1-0.60.61.1-1.0-1.0-0.8
Times rat made contact with spout1.41.62.51.41.31.5-1.4-1.41.41.01.5-0.90.91.6-1.3-1.3-0.9
Lifetime Intake0.50.61.5-0.11.00.1-0.8-0.80.81.10.5-1.21.20.2-0.40.20.3
Liver weight, left0.40.71.11.00.91.0-0.9-0.90.90.80.9-0.70.70.8-0.8-0.7-0.4
Liver weight, right0.10.20.70.1-0.50.10.30.3-0.3-0.60.20.8-0.80.30.0-0.4-0.6
Locomotor activity3.45.37.3-2.4-2.6-2.42.72.7-2.7-1.9-2.42.0-2.0-2.32.42.01.4
Locomotor testing distance1.62.93.7-1.9-1.8-1.91.91.9-1.9-1.3-1.81.3-1.3-1.91.81.61.1
Locomotor testing rearing0.00.00.20.1-0.10.10.00.0-0.0-0.00.20.3-0.30.2-0.1-0.3-0.4
Locomotion in novel chamber0.00.10.1-0.10.3-0.1-0.3-0.30.30.30.1-0.40.4-0.1-0.20.10.0
Locomotion in novel chamber post-restriction3.04.96.7-2.1-2.6-2.22.52.5-2.5-2.6-2.32.5-2.5-2.11.71.30.4
Fecal boli incidents, locomotor time 10.91.32.31.50.91.4-1.1-1.11.10.81.3-0.50.51.4-1.5-1.4-1.0
Change in fecal boli incidents, locomotor task1.41.42.5-1.3-0.9-1.21.21.2-1.2-0.2-1.30.3-0.3-1.51.51.61.5
Time >=10cm from walls, locomotor time 10.40.41.60.20.50.2-0.2-0.20.21.30.2-1.01.0-0.30.30.61.2
Bouts of movement, locomotor time 10.50.61.0-1.0-0.8-0.80.70.7-0.7-1.0-0.90.9-0.9-0.30.70.3-0.2
Total resting periods, locomotor time 11.11.31.8-1.3-1.3-1.21.21.2-1.2-1.3-1.31.3-1.3-0.71.00.60.0
Rest time, locomotor task time 10.60.81.1-0.9-1.0-0.91.01.0-1.0-0.6-0.90.7-0.7-0.91.00.90.7
Distance moved, locomotor task time 10.40.61.70.30.70.3-0.4-0.40.41.20.4-1.31.3-0.20.20.71.2
Vertical activity count, locomotor time 10.51.22.00.91.41.0-1.3-1.31.31.11.1-1.31.30.9-0.9-0.7-0.3
Time >=10cm from walls, locomotor time 20.91.31.71.21.21.1-1.3-1.31.31.11.2-1.00.91.0-1.3-1.1-0.8
Bouts of movement, locomotor time 20.40.61.8-1.0-0.6-0.80.70.7-0.70.1-0.90.1-0.0-0.71.31.11.1
Total resting periods, locomotor time 20.40.82.1-1.1-0.6-0.80.80.8-0.80.2-0.9-0.00.0-0.81.51.31.3
Rest time, locomotor task time 20.30.40.9-0.5-0.5-0.50.60.6-0.60.1-0.50.0-0.0-0.80.80.91.0
Distance moved, locomotor task time 20.20.20.70.20.30.3-0.4-0.40.4-0.10.40.1-0.10.8-0.5-0.7-0.9
Vertical activity count, locomotor time 21.42.03.21.31.41.5-1.6-1.61.60.71.5-0.80.71.8-1.6-1.7-1.4
Light reinforcement 12.56.18.1-2.8-2.7-2.82.82.8-2.8-2.2-2.72.3-2.3-2.32.22.01.2
Light reinforcement 20.81.32.0-1.4-1.3-1.41.31.3-1.3-0.8-1.31.1-1.1-1.01.00.90.5
Bone: marrow area0.30.61.90.31.00.3-0.8-0.80.81.20.4-1.41.4-0.1-0.20.30.7
Bone: maximum diameter1.01.93.9-1.7-0.9-1.71.11.1-1.1-0.4-1.60.1-0.1-1.91.62.01.7
Bone: maximum force1.73.07.91.42.01.4-1.6-1.61.62.81.4-2.72.70.5-0.80.01.1
Bone: maximum moment1.73.07.81.42.01.4-1.6-1.61.62.81.4-2.72.70.5-0.80.01.1
Mean time between licks in bursts0.30.71.5-1.1-0.8-1.20.60.6-0.6-1.2-1.20.9-0.9-0.90.70.5-0.3
Mean num. licks in bursts0.50.81.0-1.0-1.0-1.01.01.0-1.0-0.6-0.90.8-0.8-0.80.90.80.6
Cd content in liver0.30.30.9-0.9-0.3-0.90.30.3-0.3-0.8-0.80.2-0.2-0.70.60.60.1
Co content in liver2.02.34.7-1.6-1.7-1.61.51.5-1.5-2.2-1.51.9-1.9-0.91.00.5-0.4
Cu content in liver0.40.51.7-0.10.5-0.1-0.2-0.20.20.9-0.2-1.01.1-0.50.30.91.3
Fe content in liver0.30.30.50.50.60.5-0.7-0.70.70.40.4-0.50.50.7-0.6-0.5-0.5
K content in liver1.21.21.9-1.3-1.0-1.31.11.1-1.1-0.6-1.10.5-0.5-1.41.31.31.0
Mg content in liver1.41.41.9-1.4-1.2-1.41.31.3-1.3-1.1-1.10.9-0.9-1.31.31.20.8
Mn content in liver3.53.97.3-2.1-1.6-2.12.02.0-2.0-0.6-2.00.5-0.4-2.52.42.72.6
Na content in liver0.10.10.80.20.00.20.20.2-0.20.60.2-0.40.4-0.20.30.40.9
Rb content in liver0.40.51.9-0.50.2-0.40.00.0-0.00.7-0.3-0.80.9-1.00.71.21.4
Se content in liver0.00.00.0-0.2-0.1-0.10.00.0-0.0-0.1-0.10.1-0.10.00.10.1-0.0
Sr content in liver0.10.10.5-0.4-0.1-0.4-0.0-0.00.0-0.6-0.30.3-0.30.1-0.2-0.2-0.7
Zn content in liver1.82.05.5-1.1-1.5-1.21.11.1-1.1-2.3-1.12.2-2.3-0.00.2-0.4-1.6
Bone: minimum diameter0.30.51.5-0.30.5-0.3-0.2-0.20.20.9-0.2-1.11.1-0.70.41.01.2
Time in familiar zone, hab. session 13.53.46.1-1.8-2.2-1.82.02.0-2.0-2.3-1.82.5-2.5-1.11.30.7-0.3
Time in novel zone, hab. session 12.22.25.51.21.71.2-1.4-1.41.42.21.2-2.32.30.4-0.50.21.1
Total zone transitions, hab. session 10.91.32.7-1.0-1.0-1.01.21.2-1.2-0.3-1.00.3-0.3-1.41.51.61.7
Total locomotion distance, hab. session 13.14.37.3-2.2-1.9-2.22.22.2-2.2-0.9-2.00.9-0.8-2.62.62.72.5
Locomotion velocity, hab. session 12.83.95.7-2.1-1.9-2.12.12.1-2.1-1.2-1.91.1-1.0-2.32.42.42.1
Time in familiar zone, hab. session 23.43.67.4-1.9-2.2-1.91.81.8-1.8-2.7-1.92.6-2.7-1.01.10.4-0.8
Time in novel zone, hab. session 23.63.77.91.92.21.9-1.8-1.81.82.81.9-2.82.80.8-1.0-0.21.0
Total zone transitions, hab. session 20.60.83.70.10.40.1-0.0-0.00.01.4-0.0-1.31.3-0.70.71.21.9
Total locomotion distance, hab. session 20.71.02.1-0.8-0.9-0.81.11.1-1.1-0.2-0.90.3-0.3-1.21.31.31.4
Locomotion velocity, hab. session 21.01.43.2-0.9-1.0-1.01.31.3-1.3-0.2-1.00.3-0.3-1.41.61.61.8
Novel to familiar place preference ratio1.71.94.71.11.51.2-1.1-1.11.12.11.3-2.12.20.2-0.40.21.3
Novelty place preference1.11.23.40.81.20.8-0.9-0.90.91.70.9-1.81.8-0.0-0.20.41.3
Time in novel zone, NPP test1.51.64.21.11.51.1-1.1-1.11.11.91.1-2.02.10.2-0.50.21.2
Total zone transitions, NPP test0.20.31.10.60.40.5-0.2-0.20.21.00.5-0.80.9-0.00.20.41.0
Total locomotion distance, NPP test0.20.31.9-0.1-0.1-0.10.40.4-0.40.5-0.0-0.50.5-0.60.70.91.4
Locomotion velocity, NPP test0.30.41.8-0.4-0.4-0.40.70.7-0.70.1-0.3-0.10.1-0.80.91.01.3
Intraocular pressure0.40.62.00.4-0.50.40.10.1-0.1-1.10.41.1-1.10.8-0.7-1.2-1.4
Delta distance traveled before/after self-admin0.60.61.00.90.80.8-0.9-0.90.91.01.0-0.70.70.6-0.6-0.7-0.4
Delta ambulatory time before/after self-admin0.40.51.20.70.80.7-0.7-0.70.71.10.8-0.90.90.3-0.3-0.20.1
Parametrial fat weight0.30.71.60.71.00.7-0.9-0.90.91.30.8-1.11.10.4-0.5-0.20.3
Pavlov. Cond. lever latency0.60.72.50.60.40.6-0.7-0.70.7-0.10.70.2-0.31.1-1.2-1.3-1.6
Pavlov. Cond. magazine entry latency1.11.52.3-1.3-1.4-1.31.31.3-1.3-1.5-1.41.3-1.3-0.91.10.80.2
Pavlov. Cond. change in total contacts0.10.10.40.20.50.3-0.4-0.40.40.30.1-0.60.60.2-0.3-0.10.2
Pavlov. Cond. index score0.60.71.2-0.9-0.8-0.80.90.9-0.9-0.6-1.00.5-0.5-0.91.11.00.9
Pavlov. Cond. latency score0.81.11.8-1.1-0.9-1.01.11.1-1.1-0.5-1.20.4-0.4-1.21.31.31.3
Pavlov. Cond. lever contacts0.40.42.0-0.3-0.2-0.30.40.4-0.40.2-0.4-0.40.5-0.80.91.01.4
Pavlov. Cond. magazine entry number0.40.61.20.80.90.7-0.8-0.80.81.10.8-0.90.90.5-0.6-0.30.0
Pavlov. Cond. intertrial magazine entries0.20.21.00.2-0.00.1-0.2-0.20.2-0.60.10.5-0.50.5-0.5-0.7-1.0
Pavlov. Cond. lever-magazine prob. diff.0.60.81.2-0.9-0.9-0.90.90.9-0.9-0.7-1.10.6-0.5-0.91.11.00.8
Pavlov. Cond. response bias0.40.50.9-0.7-0.8-0.60.80.8-0.8-1.0-0.80.8-0.8-0.40.70.40.2
Pavlov. Cond. lever latency1.41.92.61.51.61.5-1.6-1.61.61.41.3-1.51.51.4-1.2-0.9-0.2
Pavlov. Cond. magazine entry latency2.12.53.3-1.7-1.8-1.71.81.8-1.8-1.7-1.51.6-1.6-1.51.41.10.4
Pavlov. Cond. change in total contacts0.50.81.3-1.1-1.0-1.11.01.0-1.0-1.1-0.91.0-1.0-0.80.70.5-0.1
Pavlov. Cond. index score1.62.22.9-1.6-1.7-1.61.61.6-1.6-1.7-1.51.6-1.6-1.41.20.90.1
Pavlov. Cond. latency score1.92.63.4-1.7-1.8-1.71.81.8-1.8-1.7-1.61.7-1.7-1.51.41.10.4
Pavlov. Cond. lever contacts1.21.62.3-1.3-1.5-1.41.41.4-1.4-1.5-1.21.5-1.5-1.20.90.6-0.1
Pavlov. Cond. magazine entry number2.22.73.41.81.81.8-1.8-1.81.81.71.7-1.61.61.6-1.5-1.2-0.5
Pavlov. Cond. intertrial magazine entries1.01.42.01.21.31.3-1.4-1.41.41.11.4-0.90.91.2-1.2-1.1-0.8
Pavlov. Cond. lever-magazine prob. diff.1.92.63.4-1.8-1.8-1.81.71.7-1.7-1.7-1.71.6-1.6-1.61.41.10.3
Pavlov. Cond. response bias1.82.43.8-1.7-1.8-1.71.71.7-1.7-1.9-1.51.9-1.9-1.41.10.7-0.2
Time in closed arm before self-admin0.20.31.2-0.20.1-0.20.20.2-0.20.6-0.3-0.60.6-0.70.50.81.1
Time in closed arm after self-admin0.40.50.90.30.90.2-0.9-0.90.90.60.5-0.90.9-0.1-0.8-0.3-0.3
Time in open arm before self-admin0.00.00.2-0.30.1-0.4-0.1-0.10.1-0.1-0.2-0.10.10.0-0.00.1-0.1
Time in open arm after self-admin1.82.03.81.71.31.8-1.4-1.41.41.31.7-1.11.02.0-1.3-1.3-0.7
Bone: periosteal estimation0.61.34.20.11.20.1-0.7-0.70.71.80.2-2.02.0-0.60.21.01.7
Bone: periosteal perimeter0.50.92.9-0.9-0.1-0.90.50.5-0.50.5-0.8-0.70.7-1.31.11.61.7
Bone: post-yield work0.30.50.80.60.90.6-0.8-0.80.80.90.8-0.90.90.3-0.5-0.30.0
Progressive ratio test 1 active lever presses0.30.40.70.30.80.4-0.8-0.80.80.60.7-0.70.70.6-0.5-0.3-0.4
Progressive ratio test 1 breakpoint0.40.40.80.30.90.4-0.9-0.90.90.50.8-0.70.70.6-0.5-0.3-0.4
Progressive ratio test 1 inactive lever presses0.20.20.7-0.9-0.3-0.80.30.3-0.3-0.4-0.80.3-0.3-0.50.30.50.1
Progressive ratio test 2 active lever presses0.10.10.3-0.6-0.1-0.40.10.1-0.1-0.1-0.30.1-0.1-0.00.20.40.1
Progressive ratio test 2 breakpoint0.10.10.4-0.7-0.2-0.50.30.3-0.3-0.2-0.40.2-0.2-0.10.30.40.1
Progressive ratio test 2 inactive lever presses0.10.20.5-0.50.3-0.3-0.1-0.10.10.7-0.1-0.60.7-0.10.20.60.6
Incentive Sensitization - Responses0.20.30.6-0.6-0.7-0.40.60.6-0.6-0.6-0.60.8-0.8-0.10.50.3-0.0
Incentive Sensitization - Breakpoint0.40.50.7-0.8-0.8-0.60.80.8-0.8-0.7-0.80.8-0.8-0.30.70.50.2
Sum of active levers in priming session hrs 5-60.10.10.2-0.2-0.4-0.20.30.3-0.3-0.4-0.30.4-0.4-0.20.1-0.0-0.1
Progressive ratio1.11.72.51.11.51.2-1.5-1.51.51.21.4-1.21.21.6-1.3-1.1-0.8
Food seeking constrained by brief footshock1.51.83.4-0.9-1.7-0.81.61.6-1.6-1.7-1.31.8-1.8-0.61.10.4-0.0
Seeking ratio, punishment vs. effort2.13.14.7-1.4-2.2-1.42.12.1-2.1-2.1-1.72.1-2.1-1.61.60.90.4
Retroperitoneal fat weight2.39.912.73.43.43.4-3.5-3.53.52.63.6-2.62.53.2-3.4-3.0-2.0
Reaction time number correct1.01.92.81.61.31.6-1.5-1.51.50.71.5-0.80.71.7-1.6-1.7-1.3
Reaction time mean minus median0.61.52.0-1.3-1.3-1.31.31.3-1.3-1.4-1.41.2-1.2-1.31.21.00.4
Reaction time mean minus median AUC1.22.94.8-1.8-1.6-1.81.81.8-1.8-1.1-1.80.9-0.8-2.22.12.01.7
Reaction time num false alarms0.60.91.30.91.11.0-1.1-1.11.10.91.2-0.90.91.0-0.8-0.7-0.4
Reaction time num false alarms AUC0.71.11.80.91.11.1-1.2-1.21.20.81.3-0.80.81.1-1.0-1.0-0.7
Reaction time trials correct on left1.01.92.81.61.31.6-1.5-1.51.50.71.5-0.80.71.7-1.6-1.7-1.3
Reaction time trials on left0.91.72.51.61.21.5-1.4-1.41.40.71.4-0.80.71.6-1.5-1.6-1.2
Reaction time mean1.42.23.3-1.5-1.5-1.41.61.6-1.6-1.2-1.61.0-1.0-1.81.71.61.2
Reaction time mean AUC0.81.22.3-1.1-1.0-1.11.21.2-1.2-0.7-1.30.5-0.5-1.51.41.31.1
Median of all reaction times1.01.42.2-1.1-1.2-1.11.31.3-1.3-0.9-1.40.7-0.6-1.51.51.41.2
Reaction time omissions0.20.31.1-0.7-0.1-0.60.30.3-0.30.1-0.5-0.20.3-1.10.60.90.8
Reaction time false alarm rate0.10.10.30.20.40.3-0.4-0.40.40.50.5-0.50.50.2-0.10.00.2
Reaction time premature initiation rate0.81.13.1-0.7-1.3-0.81.01.0-1.0-1.5-0.61.7-1.8-0.00.4-0.2-0.9
Reaction time premature initiations0.40.72.60.1-0.60.10.20.2-0.2-1.10.21.3-1.40.9-0.5-1.1-1.6
Std. dev. reaction times0.81.42.2-1.3-1.1-1.31.21.2-1.2-1.0-1.30.8-0.8-1.51.31.30.9
Reaction time trials completed0.91.72.51.61.21.5-1.4-1.41.40.71.4-0.80.71.6-1.5-1.6-1.2
Reaction time trials AUC1.22.23.41.81.31.7-1.6-1.61.60.81.6-0.80.71.8-1.7-1.8-1.4
Run reversals in cocaine runway, females2.92.93.8-1.8-1.8-1.81.91.9-1.9-1.5-2.01.4-1.4-1.52.01.71.1
Run reversals in cocaine runway, males2.82.94.5-1.7-1.8-1.91.91.9-1.9-1.3-2.01.3-1.2-2.11.51.61.2
Latency to leave start box in cocaine runway0.50.51.8-0.30.0-0.30.30.3-0.30.80.0-0.80.9-1.01.01.11.4
Latency to leave start box in cocaine runway, F0.80.93.3-0.3-0.1-0.30.50.5-0.51.0-0.1-1.01.0-1.31.31.41.8
Latency to leave start box in cocaine runway, M0.10.10.30.00.20.1-0.3-0.30.30.00.3-0.0-0.00.3-0.3-0.4-0.5
Std. dev. time between licks in bursts1.11.53.3-1.4-0.9-1.51.11.1-1.1-0.4-1.40.4-0.4-1.81.51.71.2
Total sessions with >9 infusions0.40.51.4-0.40.9-0.3-0.7-0.70.71.10.2-1.21.2-0.3-0.30.50.4
Short access day 1 total inactive lever presses0.20.30.7-0.6-0.5-0.60.30.3-0.3-0.6-0.60.8-0.9-0.10.2-0.1-0.5
Short access day 10 total inactive lever presses0.20.52.40.20.10.2-0.4-0.40.4-0.80.10.8-0.90.9-0.8-1.1-1.6
Short access day 1 total infusions0.40.51.4-0.41.0-0.3-0.8-0.80.81.10.3-1.21.2-0.3-0.30.40.3
Short access day 10 total infusions0.20.20.4-0.10.6-0.0-0.6-0.60.60.50.3-0.60.60.2-0.30.0-0.2
Short access total infusions0.60.82.1-0.11.10.0-0.9-0.90.91.40.5-1.51.50.1-0.50.30.4
Short access day 1 locomotion0.30.41.4-1.2-0.3-1.20.20.2-0.2-0.8-0.60.6-0.6-0.70.40.5-0.3
Short access day 10 total locomotion0.81.44.3-1.4-1.0-1.50.60.6-0.6-2.1-1.11.8-1.8-0.30.30.0-1.3
Short access total locomotion0.20.30.9-0.9-0.3-1.00.10.1-0.1-0.7-0.50.6-0.6-0.50.10.3-0.5
One hour access (0.3 mA shock)0.20.30.60.40.50.5-0.5-0.50.50.30.6-0.30.30.7-0.7-0.5-0.4
Compulsive drug intake0.10.10.2-0.1-0.3-0.20.30.3-0.30.2-0.20.1-0.1-0.40.10.20.4
One hour access (shock baseline)0.00.00.2-0.40.0-0.2-0.1-0.10.1-0.3-0.00.2-0.20.20.10.1-0.3
Social response proportion1.01.22.0-0.8-1.4-0.81.41.4-1.4-0.7-1.11.1-1.1-0.81.20.90.6
Social responses8.711.314.8-3.5-3.8-3.53.83.8-3.8-2.9-3.53.4-3.3-3.13.42.71.4
Social time1.21.72.71.61.31.6-1.4-1.41.41.01.4-1.11.01.4-1.3-1.3-0.7
Soleus weight5.114.920.24.24.34.3-4.1-4.14.14.54.2-4.34.33.1-3.4-2.6-0.7
Bone: stiffness2.54.19.21.82.41.8-2.1-2.12.13.01.8-2.92.91.1-1.2-0.40.7
Tibialis anterior weight1.13.95.02.22.22.2-2.1-2.12.12.22.1-2.12.11.6-1.8-1.4-0.4
Time to tail flick, vehicle, before self-admin1.61.63.9-1.4-1.1-1.41.31.3-1.3-0.8-1.50.7-0.6-2.01.31.41.1
Time to tail flick, vehicle, after self-admin0.40.51.80.1-0.40.10.10.1-0.1-1.1-0.01.1-1.10.8-0.3-0.9-1.3
Time to tail flick, test, before self-admin1.31.32.5-1.3-0.9-1.41.11.1-1.1-0.5-1.20.3-0.3-1.51.41.61.3
Time to tail flick, test, after self-admin0.10.10.4-0.3-0.0-0.40.20.2-0.20.3-0.3-0.30.3-0.70.30.60.6
Delta time to tail flick, vehicle, before/after SA2.52.45.51.91.21.8-1.5-1.51.50.41.7-0.40.32.4-1.6-2.0-1.8
Delta time to tail flick, test, before/after SA0.50.51.50.70.20.7-0.5-0.50.5-0.20.60.3-0.40.9-0.9-1.2-1.2
Tibia length0.61.83.5-1.2-1.6-1.11.41.4-1.4-1.9-1.01.9-1.9-0.61.00.4-0.3
Ambulatory time before self-admin0.30.40.6-0.7-0.8-0.60.70.7-0.7-0.8-0.60.7-0.7-0.50.50.30.2
Ambulatory time after self-admin0.00.00.00.1-0.10.10.10.1-0.10.20.10.0-0.0-0.10.1-0.00.1
Bone: tissue strength3.93.97.51.82.41.8-2.1-2.12.12.71.9-2.72.71.2-1.5-0.70.3
Total heroin consumption2.12.53.4-1.6-1.8-1.61.81.8-1.8-1.4-1.71.6-1.5-1.51.61.30.8
Bone: trabecular number0.91.53.0-1.3-1.0-1.31.31.3-1.3-0.2-1.00.2-0.2-1.71.51.71.7
Bone: trabecular spacing1.52.06.11.20.81.2-1.3-1.31.3-0.51.10.3-0.42.0-1.8-2.2-2.5
Bone: trabecular thickness2.22.811.2-1.1-0.3-1.11.01.0-1.01.4-1.0-1.31.4-2.21.92.73.3
Bone: trabecular tissue density4.46.58.32.72.92.7-2.9-2.92.92.52.8-2.52.52.4-2.5-2.1-1.2
Water consumed over 24 hours0.40.51.50.50.80.5-0.5-0.50.51.20.7-1.21.20.0-0.00.30.8
Number of responses in last shaping day1.51.63.3-1.8-1.1-1.70.90.9-0.9-1.7-1.41.5-1.5-1.00.90.7-0.5