Hub : Genes

Ddit4l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Ddit4l 0.38 0.13 3.2e-06 0.14 0.15 0.17 0.17 3.1e-04 2.2e-04 6.8e-05 6.6e-05
2 IC gene expression Ddit4l 0.21 0.07 1.7e-09 0.16 0.22 0.23 0.21 4.0e-07 1.9e-09 6.0e-10 2.7e-09
3 BLA gene expression Ddit4l 0.07 0.04 6.5e-03 -0 0.01 0 -0 4.7e-01 1.1e-01 1.6e-01 3.8e-01
4 LHb gene expression Ddit4l 0.19 0.1 1.2e-03 0.08 0.12 0.05 0.08 6.3e-03 1.2e-03 2.1e-02 5.9e-03
5 NAcc gene expression Ddit4l 0.12 0.05 5.6e-17 0.09 0.11 0.11 0.12 1.3e-13 5.9e-16 7.2e-17 5.3e-17
6 pVTA gene expression Ddit4l 0.16 0.07 2.2e-07 0.11 0.09 0.11 0.1 2.7e-09 1.3e-07 7.1e-09 1.1e-08
7 PL gene expression Ddit4l 0.04 0.03 2.4e-03 0.02 0.02 0.02 0.02 3.5e-03 2.9e-03 4.4e-03 3.1e-03
8 Brain gene expression Ddit4l 0.18 0.06 2.4e-13 0.14 0.16 0.16 0.16 1.2e-12 7.2e-15 1.8e-14 1.8e-14
9 Adipose gene expression Ddit4l 0.04 0.03 2.4e-03 0.02 0.02 0.02 0.02 6.4e-03 2.0e-03 2.1e-03 2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density1.62.74.2-0.6-1.81.0-1.8-1.8-2.0-2.1-1.8-1.3
Area under the delay curve0.10.10.3-0.50.3-0.30.1-0.3-0.00.0-0.2-0.0
BMI with tail1.75.917.04.13.0-1.62.32.62.41.91.60.6
BMI without tail1.64.916.54.12.7-1.51.62.51.91.71.70.1
Body weight1.67.026.45.12.9-2.22.62.62.21.71.40.2
Weight adjusted by age0.10.20.70.10.4-0.30.50.70.80.30.3-0.4
Bone surface0.30.51.10.5-0.51.0-1.0-0.4-0.4-1.0-0.6-0.4
Bone volume0.40.81.70.4-0.81.0-1.3-0.6-0.7-1.3-0.7-0.7
Breakpoint value in progressive ratio session0.81.02.9-0.1-0.6-1.0-0.1-1.3-1.7-0.3-1.3-1.0
Number of licking bursts0.61.03.81.30.7-1.11.90.50.61.00.00.4
Context. condit. distance diff. score0.20.30.9-0.6-0.6-0.30.3-1.0-0.50.1-0.70.1
Locomotion velocity, session 11.82.03.40.91.2-1.81.81.61.81.01.1-0.6
Locomotion distance, session 12.93.78.70.81.8-3.02.81.52.12.11.2-0.4
Locomotion velocity, session 20.30.30.8-0.30.2-0.90.70.30.6-0.0-0.2-0.9
Locomotion distance, session 22.83.99.3-0.02.0-3.12.81.52.22.11.4-0.4
Locomotion velocity, session 32.52.84.61.51.4-1.62.21.61.92.01.70.7
Locomotion distance, session 30.70.71.40.70.7-0.31.20.71.11.00.70.9
Stereotopy head waving bouts, day 30.50.51.20.60.4-0.50.71.00.70.81.10.6
Stereotopy head waving duration, day 31.01.22.11.51.0-0.91.21.30.91.11.20.5
Locomotion velocity, session 70.91.03.20.81.1-1.81.50.40.70.70.1-0.5
Locomotion distance, session 71.82.35.21.41.8-1.92.30.91.51.80.50.3
Stereotopy head waving bouts, day 70.30.30.9-0.5-0.70.7-0.60.50.1-0.21.00.1
Stereotopy head waving duration, day 70.40.41.9-0.5-0.30.4-0.30.90.70.21.40.4
Locomotion velocity, session 80.40.41.3-0.00.3-1.21.00.40.80.70.3-0.4
Locomotion distance, session 82.23.211.70.01.4-3.42.90.41.32.00.4-0.6
Degree of sensitization distance0.30.31.20.30.6-1.10.6-0.3-0.10.3-0.6-0.8
Degree of sensitization stereotypy0.50.61.7-0.7-1.00.8-1.3-0.0-0.5-0.80.5-0.3
Conditioned locomotion1.01.23.3-1.2-1.31.0-1.8-0.1-0.6-1.10.1-1.2
Cocaine response after cond. corrected1.01.22.0-0.6-1.30.4-1.2-1.1-1.4-1.4-0.8-1.1
Cocaine response after cond. not corrected1.82.13.9-1.0-1.60.5-1.6-1.5-1.4-2.0-1.3-1.7
Cocaine response before conditioning0.20.21.00.10.5-0.40.30.51.00.30.2-0.3
Saline control response3.14.17.30.92.3-0.21.52.72.72.12.41.9
Bone: connectivity density1.62.43.6-1.2-1.91.0-1.4-1.8-1.7-1.7-1.9-1.1
Bone: cortical apparent density0.20.31.0-0.2-0.3-0.4-0.0-0.8-1.0-0.3-0.7-0.1
Bone: cortical area1.11.710.13.21.30.50.31.30.70.20.60.8
Bone: cortical porosity0.80.91.60.80.9-1.00.81.11.30.81.0-0.2
Bone: cortical porosity1.11.22.01.21.3-1.41.01.21.31.01.1-0.3
Bone: cortical thickness0.50.86.12.50.2-0.2-0.3-0.1-0.7-0.4-0.4-0.5
Bone: cortical thickness0.50.62.50.9-0.2-0.4-0.7-0.2-0.6-1.1-0.6-1.6
Bone: cortical tissue density0.20.20.9-0.2-0.2-0.50.1-0.8-0.9-0.2-0.60.0
Condit. Reinf. active minus inactive responses2.52.85.71.21.9-2.22.41.31.42.01.10.7
Condit. Reinf. active-inactive response ratio3.23.47.52.02.3-2.62.71.01.11.90.70.8
Condit. Reinf. active responses1.11.32.40.21.4-1.41.61.01.11.41.00.4
Condit. Reinf. inactive responses0.50.61.5-1.2-0.81.2-1.20.2-0.2-0.50.4-0.2
Incentive salience index mean1.41.73.31.21.5-1.51.81.21.11.61.00.5
Condit. Reinf. lever presses0.30.41.00.60.30.20.41.00.70.70.90.5
Condit. Reinf. active minus inactive responses0.60.83.21.1-0.61.8-0.70.4-0.4-0.60.11.0
Condit. Reinf. active-inactive response ratio0.60.71.70.6-1.01.1-0.5-0.6-1.3-0.7-0.60.6
Condit. Reinf. active responses0.40.62.71.60.11.1-0.30.90.2-0.30.30.6
Condit. Reinf. inactive responses1.41.93.61.91.7-0.51.01.81.81.01.20.3
Condit. Reinf. lever presses0.40.62.21.5-0.31.2-0.40.3-0.3-0.9-0.40.1
Condit. Reinf. lever reinforcers received0.30.51.81.3-0.11.1-0.50.6-0.1-0.6-0.00.3
Conditioned reinforcement - actives0.91.53.80.10.50.31.01.20.81.81.82.0
Conditioned reinforcement - inactives0.30.51.3-1.2-0.51.0-0.7-0.3-0.6-0.10.30.9
Conditioned locomotion0.40.52.7-0.3-0.71.7-0.70.10.10.30.50.8
Patch foraging indifference point 0 sec0.10.21.1-0.5-0.10.60.3-0.10.40.5-0.01.0
Patch foraging indifference point AUC0.40.63.71.90.70.50.40.60.40.10.00.7
Delay disc. indifference point, 0s delay0.90.94.5-0.2-0.42.1-0.50.10.20.00.31.8
Delay disc. indifference point, 16s delay0.60.71.40.71.2-1.01.20.60.70.90.30.1
Delay disc. indifference point, 2s delay0.70.83.2-1.1-0.81.8-1.1-0.3-0.1-0.40.30.7
Delay disc. indifference point, 24s delay0.40.42.2-1.5-0.30.2-0.9-0.5-0.3-0.3-0.3-0.4
Delay disc. indifference point, 4s delay0.50.51.1-1.0-0.30.0-0.4-0.8-0.7-0.9-1.0-0.6
Delay disc. indifference point, 8s delay0.80.92.8-0.11.1-1.71.10.51.01.10.8-0.2
Indifference point function ln k0.81.43.9-0.11.0-2.01.70.61.21.50.8-0.0
Indifference point function log k0.81.43.9-0.11.0-2.01.70.61.21.50.8-0.0
Patch foraging total patch changes 0 sec0.10.31.1-0.20.10.40.60.20.60.60.11.0
Patch foraging total patch changes 12 sec0.10.20.60.50.30.60.20.0-0.00.0-0.40.8
Patch foraging total patch changes 18 sec0.20.31.10.20.40.60.70.10.40.3-0.21.0
Patch foraging total patch changes 24 sec0.71.12.21.00.70.41.11.21.11.11.11.5
Patch foraging total patch changes 6 sec0.30.40.90.9-0.20.90.1-0.5-0.3-0.2-0.90.8
Patch foraging time to switch 0 sec0.91.94.7-2.2-1.81.0-1.5-1.4-1.6-1.1-0.5-0.2
Patch foraging water rate 0 sec0.40.82.91.70.7-0.81.00.80.80.3-0.0-0.8
Patch foraging water rate 12 sec1.02.13.31.71.8-1.81.81.31.21.31.00.1
Patch foraging water rate 18 sec0.30.52.11.40.3-0.71.00.40.20.2-0.3-0.4
Patch foraging water rate 24 sec1.42.05.01.61.4-2.02.21.01.11.50.4-0.1
Patch foraging water rate 6 sec2.94.216.42.12.2-4.02.80.70.71.50.1-1.3
Seeking ratio, delayed vs. immediate footshock2.42.95.2-2.3-2.21.3-2.1-1.6-1.0-1.7-1.2-1.3
Distance traveled before self-admin0.50.61.30.0-0.41.1-0.31.20.80.51.10.6
Distance traveled after self-admin0.20.21.2-0.2-0.10.70.10.30.20.40.41.1
Extensor digitorum longus weight1.97.326.65.23.1-2.11.73.21.91.52.50.0
Bone: elastic displacement0.70.82.01.40.9-0.80.61.00.70.90.9-0.1
Bone: elastic work0.70.93.92.00.9-1.40.60.40.10.40.2-1.0
Bone: endosteal estimation1.02.23.61.61.61.10.81.91.90.81.31.8
Bone: endosteal perimeter1.53.15.21.91.80.71.12.32.11.41.92.1
Epididymis fat weight1.65.69.33.02.5-0.22.32.73.02.02.02.2
Delta time in closed arm before/after self-admin0.80.81.20.31.0-0.61.10.91.01.00.80.9
Delta time in open arm before/after self-admin1.71.74.3-0.01.00.20.51.31.41.52.11.9
Diff in mean of infusions in LGA sessions2.42.95.9-1.4-1.6-0.3-0.7-2.4-2.4-1.4-2.4-1.1
Delay discount exponential model param0.10.20.60.8-0.10.40.10.50.20.20.40.3
Extinction: sum of active levers before priming1.21.32.4-0.3-0.7-0.7-0.7-1.3-1.5-1.1-1.5-1.5
Active lever presses in extinction session 60.70.71.7-1.3-0.80.1-0.3-1.3-1.1-0.2-1.2-0.1
Bone: final force0.20.41.31.20.80.10.60.60.30.30.20.7
Bone: final moment0.20.31.41.20.70.10.40.50.20.1-0.00.4
Food consumed during 24 hour testing period0.71.02.81.41.2-1.71.10.30.4-0.0-0.3-1.0
Glucose0.91.44.32.11.6-1.51.20.80.90.60.0-0.4
Heart weight1.52.47.12.71.9-0.81.01.91.71.11.20.2
Delay discount hyperbolic model param0.10.20.80.90.00.00.20.50.30.30.40.1
Intermittent access intake day 1-15 change0.20.51.6-0.9-1.01.3-0.6-0.2-0.1-0.4-0.00.4
Intermittent access intake escalation0.40.82.5-1.1-1.31.6-0.9-0.5-0.4-0.6-0.40.3
Intermittent access intake escalation 21.71.94.0-1.4-2.01.2-1.2-1.5-1.5-1.5-1.3-0.7
Intermitt. access day 1 inactive lever presses0.10.41.30.61.1-1.10.50.30.50.60.2-0.1
Intermitt. access day 15 inactive lever presses0.71.42.51.61.3-1.20.71.61.30.91.0-0.7
Intermitt. access escalation Index0.10.10.3-0.20.2-0.4-0.50.20.20.10.5-0.6
Intermittent access day 1 total infusions0.81.32.71.51.7-1.51.21.10.70.90.5-0.1
Intermittent access day 15 total infusions0.10.10.30.40.3-0.10.50.50.50.30.10.0
Intermittent access terminal intake (last 3 days)0.40.51.30.50.7-0.91.10.60.70.80.20.1
Intermittent access total infusions0.91.12.01.21.3-1.31.41.00.81.10.50.1
Intermittent access day 1 locomotion1.31.63.71.91.5-0.71.21.41.31.21.00.6
Intermittent access day 15 total locomotion0.40.72.40.6-0.21.5-0.00.70.80.60.71.2
Intermittent access total locomotion0.20.20.90.9-0.10.60.10.50.30.20.20.3
Intermittent access standard deviation0.10.20.90.50.10.80.20.30.10.20.10.9
Left kidney weight0.62.710.73.31.9-1.41.31.51.31.11.1-0.1
Right kidney weight0.73.19.73.12.1-1.61.51.81.61.21.2-0.1
Cocaine induced anxiety0.20.31.00.70.30.60.40.50.40.50.31.0
Post-drug Anxiety0.40.41.60.3-0.11.20.10.40.70.40.41.3
Baseline Anxiety0.10.10.2-0.4-0.2-0.3-0.2-0.4-0.3-0.3-0.2-0.3
Tail length0.10.21.91.4-0.00.1-0.30.3-0.2-0.20.3-0.1
Length with tail0.31.16.52.50.7-1.10.90.70.60.20.3-0.4
Length without tail0.30.93.41.80.8-0.41.30.71.00.40.30.5
Times rat made contact with spout3.13.58.3-0.8-1.5-1.1-0.7-2.1-2.2-1.9-2.3-2.9
Lifetime Intake1.21.52.61.21.6-1.51.61.20.91.40.70.2
Liver weight, left0.50.81.51.00.50.01.00.90.71.21.11.0
Liver weight, right0.20.42.00.50.10.60.50.1-0.10.60.21.4
Locomotor activity0.10.20.40.30.6-0.70.40.10.50.0-0.4-0.5
Locomotor testing distance0.30.62.00.71.1-1.40.70.40.70.2-0.2-0.9
Locomotor testing rearing0.81.64.00.30.4-2.00.6-1.0-0.7-0.8-1.9-2.0
Locomotion in novel chamber5.16.610.5-2.8-3.21.9-2.9-2.5-2.2-2.6-2.3-2.2
Locomotion in novel chamber post-restriction0.91.53.5-1.1-1.0-0.3-1.3-1.2-1.1-1.4-1.1-1.9
Fecal boli incidents, locomotor time 10.20.20.8-0.20.40.20.40.50.50.40.60.9
Change in fecal boli incidents, locomotor task0.50.52.20.30.4-1.50.3-0.1-0.20.3-0.3-1.4
Time >=10cm from walls, locomotor time 10.80.82.30.0-1.10.3-0.6-1.5-1.2-0.4-1.3-0.4
Bouts of movement, locomotor time 10.50.61.5-0.1-0.80.1-0.4-0.9-0.9-1.0-1.2-0.5
Total resting periods, locomotor time 10.20.20.60.2-0.4-0.20.1-0.5-0.4-0.5-0.8-0.3
Rest time, locomotor task time 10.20.20.5-0.2-0.60.6-0.7-0.0-0.6-0.50.20.2
Distance moved, locomotor task time 10.20.30.90.71.0-0.90.5-0.10.50.4-0.2-0.2
Vertical activity count, locomotor time 10.00.10.20.30.4-0.20.3-0.10.40.1-0.3-0.1
Time >=10cm from walls, locomotor time 22.02.93.91.71.8-1.51.71.91.92.01.90.5
Bouts of movement, locomotor time 20.30.52.1-0.9-0.51.4-0.9-0.4-0.1-0.4-0.20.8
Total resting periods, locomotor time 20.30.62.2-0.9-0.61.5-0.9-0.4-0.1-0.5-0.20.6
Rest time, locomotor task time 20.91.12.6-0.6-1.01.5-1.6-0.6-0.8-1.4-0.6-0.5
Distance moved, locomotor task time 20.50.61.10.11.0-0.81.00.40.71.10.60.5
Vertical activity count, locomotor time 20.10.10.1-0.20.1-0.30.30.20.40.40.3-0.1
Light reinforcement 11.94.87.92.82.4-2.12.62.42.32.11.50.2
Light reinforcement 20.10.20.80.80.2-0.50.20.10.0-0.2-0.1-0.9
Bone: marrow area0.92.03.31.51.61.10.81.81.80.71.21.8
Bone: maximum diameter1.01.95.92.41.51.00.51.61.40.60.91.5
Bone: maximum force0.61.03.11.71.2-0.11.01.00.90.70.50.9
Bone: maximum moment0.40.72.81.71.10.00.70.70.70.40.20.6
Mean time between licks in bursts0.10.31.20.50.5-0.00.7-0.10.30.6-0.11.1
Mean num. licks in bursts1.72.74.6-1.5-1.50.3-2.2-1.6-1.7-2.0-1.4-2.1
Cd content in liver0.30.42.10.6-0.00.50.4-0.2-0.40.2-0.21.5
Co content in liver6.37.39.82.63.1-2.13.03.02.83.12.61.6
Cu content in liver1.01.13.0-1.5-1.70.6-0.5-1.3-1.1-0.6-1.1-0.4
Fe content in liver1.01.35.7-0.6-0.92.4-1.20.60.1-0.20.91.3
K content in liver0.90.93.1-1.0-1.11.8-1.1-0.4-0.4-0.8-0.40.2
Mg content in liver0.10.10.6-0.8-0.60.40.1-0.20.1-0.1-0.30.1
Mn content in liver0.50.61.3-0.1-0.41.1-1.0-0.5-0.8-1.0-0.80.3
Na content in liver0.10.10.3-0.4-0.30.5-0.5-0.3-0.4-0.3-0.3-0.2
Rb content in liver0.70.93.6-0.2-0.11.00.40.70.60.91.11.9
Se content in liver0.30.31.5-0.3-0.41.2-0.60.30.4-0.40.40.5
Sr content in liver0.30.20.8-0.20.20.4-0.9-0.2-0.5-0.7-0.3-0.3
Zn content in liver10.912.119.4-4.2-4.43.5-2.7-4.4-3.5-2.6-3.80.1
Bone: minimum diameter2.34.212.43.52.6-0.71.72.32.01.41.61.3
Time in familiar zone, hab. session 10.30.30.70.3-0.40.00.50.80.70.30.7-0.1
Time in novel zone, hab. session 10.20.20.6-0.20.30.6-0.8-0.2-0.30.00.10.7
Total zone transitions, hab. session 12.83.87.31.11.8-2.52.72.12.31.91.7-0.2
Total locomotion distance, hab. session 10.50.61.80.60.5-1.21.30.70.70.70.5-0.4
Locomotion velocity, hab. session 10.50.62.30.50.5-1.51.30.40.50.50.1-0.8
Time in familiar zone, hab. session 21.41.53.30.1-1.21.1-1.8-0.6-1.7-1.6-0.9-1.0
Time in novel zone, hab. session 20.80.82.1-0.50.7-0.21.10.21.21.20.71.5
Total zone transitions, hab. session 22.63.46.71.21.7-2.52.61.71.92.11.4-0.2
Total locomotion distance, hab. session 20.60.72.80.70.9-1.71.10.40.30.70.0-0.7
Locomotion velocity, hab. session 20.50.62.50.40.8-1.61.10.30.30.7-0.0-0.7
Novel to familiar place preference ratio0.20.20.7-0.00.3-0.80.4-0.20.1-0.1-0.5-0.6
Novelty place preference0.30.31.0-0.00.4-1.00.4-0.20.1-0.1-0.6-0.9
Time in novel zone, NPP test0.30.31.10.00.4-1.10.4-0.20.1-0.1-0.6-0.9
Total zone transitions, NPP test2.13.05.91.52.0-2.32.41.61.71.71.10.0
Total locomotion distance, NPP test0.20.31.10.50.3-1.10.9-0.1-0.10.3-0.4-0.5
Locomotion velocity, NPP test0.30.41.30.60.3-1.10.8-0.2-0.40.0-0.7-0.7
Intraocular pressure0.20.31.0-0.2-0.11.0-0.80.2-0.20.20.60.9
Delta distance traveled before/after self-admin0.40.41.6-0.10.9-0.31.0-0.40.10.3-0.31.3
Delta ambulatory time before/after self-admin0.30.30.7-0.00.7-0.50.8-0.7-0.40.1-0.70.8
Parametrial fat weight0.20.41.70.3-0.01.20.10.10.70.20.11.3
Pavlov. Cond. lever latency0.40.52.20.60.7-1.50.4-0.3-0.1-0.1-0.2-1.0
Pavlov. Cond. magazine entry latency0.50.71.60.10.8-0.10.50.91.11.11.20.8
Pavlov. Cond. change in total contacts0.20.20.8-0.9-0.0-0.30.60.10.40.60.30.4
Pavlov. Cond. index score0.20.20.6-0.7-0.60.8-0.4-0.2-0.2-0.00.00.4
Pavlov. Cond. latency score0.30.41.2-0.8-0.71.1-0.6-0.2-0.3-0.1-0.00.6
Pavlov. Cond. lever contacts0.30.31.6-0.1-0.71.3-0.30.2-0.00.10.20.9
Pavlov. Cond. magazine entry number0.50.61.3-0.0-0.80.6-0.8-0.7-0.7-1.1-1.0-0.8
Pavlov. Cond. intertrial magazine entries0.20.31.10.2-0.21.0-0.00.30.00.10.21.0
Pavlov. Cond. lever-magazine prob. diff.0.20.20.8-0.9-0.70.6-0.5-0.4-0.4-0.2-0.20.1
Pavlov. Cond. response bias0.50.61.20.00.20.10.70.80.71.11.11.0
Pavlov. Cond. lever latency0.91.25.1-2.3-1.00.4-1.3-1.1-0.9-0.7-0.5-0.7
Pavlov. Cond. magazine entry latency0.00.10.2-0.3-0.20.5-0.20.20.1-0.20.10.2
Pavlov. Cond. change in total contacts0.10.20.80.90.40.30.50.30.20.1-0.10.6
Pavlov. Cond. index score0.20.20.90.8-0.20.9-0.10.3-0.0-0.30.10.4
Pavlov. Cond. latency score0.20.21.10.4-0.51.1-0.2-0.1-0.3-0.4-0.10.5
Pavlov. Cond. lever contacts0.91.25.62.41.0-0.01.01.10.80.50.60.8
Pavlov. Cond. magazine entry number0.10.20.9-0.20.3-0.90.2-0.30.00.4-0.1-0.4
Pavlov. Cond. intertrial magazine entries0.20.20.90.7-0.20.0-0.5-0.0-0.1-0.6-0.4-0.9
Pavlov. Cond. lever-magazine prob. diff.0.20.21.00.7-0.41.0-0.20.2-0.1-0.30.00.4
Pavlov. Cond. response bias1.11.55.32.31.2-0.11.11.51.20.61.00.7
Time in closed arm before self-admin0.20.20.4-0.3-0.2-0.60.5-0.5-0.60.1-0.5-0.6
Time in closed arm after self-admin0.40.51.2-0.7-0.4-0.60.4-0.9-0.8-0.2-1.1-0.6
Time in open arm before self-admin1.01.12.40.7-0.1-0.4-0.7-0.9-1.0-1.5-1.5-1.6
Time in open arm after self-admin0.40.41.20.40.60.2-0.10.70.70.51.10.9
Bone: periosteal estimation1.22.58.32.91.90.70.81.91.50.61.11.4
Bone: periosteal perimeter1.73.07.22.72.00.60.82.11.81.01.71.7
Bone: post-yield work0.60.92.60.10.50.70.90.51.41.00.71.6
Progressive ratio test 1 active lever presses2.43.06.11.42.4-2.52.11.61.41.71.10.1
Progressive ratio test 1 breakpoint2.32.86.21.42.3-2.52.11.41.31.70.90.1
Progressive ratio test 1 inactive lever presses0.20.31.40.00.8-1.20.00.20.00.0-0.0-1.0
Progressive ratio test 2 active lever presses0.50.61.21.10.9-0.90.80.80.40.50.50.1
Progressive ratio test 2 breakpoint0.30.41.01.00.7-0.90.70.60.30.30.3-0.2
Progressive ratio test 2 inactive lever presses0.20.20.80.40.3-0.10.20.80.30.50.90.2
Incentive Sensitization - Responses0.50.72.5-0.6-1.51.6-0.8-0.3-0.4-0.60.10.5
Incentive Sensitization - Breakpoint0.60.82.6-0.6-1.51.6-1.0-0.3-0.5-0.7-0.00.3
Sum of active levers in priming session hrs 5-65.85.39.4-2.2-2.3-0.0-2.0-3.0-3.1-2.0-2.6-2.2
Progressive ratio0.10.20.80.40.20.2-0.90.10.1-0.60.1-0.7
Food seeking constrained by brief footshock0.30.42.61.60.3-0.40.60.3-0.0-0.0-0.30.1
Seeking ratio, punishment vs. effort0.20.41.2-0.2-0.1-1.11.0-0.4-0.50.4-0.6-0.2
Retroperitoneal fat weight0.31.45.22.31.20.30.71.31.60.20.50.7
Reaction time number correct0.20.31.40.20.2-0.90.0-0.1-0.1-0.3-0.4-1.2
Reaction time mean minus median0.92.24.1-1.5-1.61.9-2.0-1.1-1.5-1.8-0.70.0
Reaction time mean minus median AUC1.02.64.3-1.6-1.81.8-2.1-1.4-1.9-1.8-0.9-0.0
Reaction time num false alarms1.52.14.40.21.5-0.51.01.82.01.62.10.9
Reaction time num false alarms AUC1.82.86.00.51.7-0.41.12.22.31.72.51.1
Reaction time trials correct on left0.20.31.40.20.2-0.90.0-0.1-0.1-0.3-0.4-1.2
Reaction time trials on left0.20.31.60.10.1-0.8-0.1-0.2-0.2-0.4-0.5-1.3
Reaction time mean1.32.04.0-0.9-1.20.6-2.0-1.2-1.8-1.8-1.1-1.5
Reaction time mean AUC1.11.73.5-0.9-1.00.4-1.9-1.2-1.7-1.7-1.0-1.4
Median of all reaction times1.01.43.3-0.4-0.7-0.2-1.5-0.9-1.4-1.5-1.0-1.8
Reaction time omissions1.82.75.7-2.0-1.72.2-2.4-1.2-1.3-1.8-0.60.0
Reaction time false alarm rate1.21.63.80.11.10.10.81.61.81.42.01.2
Reaction time premature initiation rate3.14.37.12.52.4-1.11.72.72.32.12.31.0
Reaction time premature initiations2.34.16.62.52.4-1.51.62.62.12.02.10.4
Std. dev. reaction times1.73.25.9-1.9-2.02.2-2.4-1.4-1.9-1.9-0.8-0.0
Reaction time trials completed0.20.31.60.10.1-0.8-0.1-0.2-0.2-0.4-0.5-1.3
Reaction time trials AUC0.10.31.20.30.3-0.90.1-0.1-0.1-0.2-0.3-1.1
Run reversals in cocaine runway, females0.80.81.8-1.0-0.3-0.4-0.5-0.8-1.0-1.0-1.2-1.3
Run reversals in cocaine runway, males1.41.53.9-1.00.1-2.00.0-1.2-1.0-0.7-1.2-1.9
Latency to leave start box in cocaine runway0.10.10.20.10.10.10.40.20.50.5-0.10.4
Latency to leave start box in cocaine runway, F0.80.92.70.60.70.21.00.70.91.30.81.7
Latency to leave start box in cocaine runway, M1.51.43.9-0.9-1.3-0.1-0.9-1.0-0.8-1.2-1.5-2.0
Std. dev. time between licks in bursts1.21.64.90.31.3-1.52.20.41.51.60.30.8
Total sessions with >9 infusions2.73.25.50.92.3-1.62.31.81.62.31.51.3
Short access day 1 total inactive lever presses0.60.82.40.50.8-1.31.60.71.00.90.4-0.1
Short access day 10 total inactive lever presses0.10.21.1-1.0-0.40.7-0.40.10.5-0.00.20.1
Short access day 1 total infusions2.22.95.70.31.8-1.22.11.81.82.41.81.4
Short access day 10 total infusions1.41.74.60.41.9-2.11.61.00.91.50.7-0.2
Short access total infusions1.92.55.20.62.3-2.32.01.31.21.80.90.0
Short access day 1 locomotion2.53.16.91.01.8-1.42.31.61.52.61.51.5
Short access day 10 total locomotion0.00.10.2-0.20.2-0.20.2-0.3-0.40.1-0.50.1
Short access total locomotion0.60.71.40.61.2-0.41.00.70.81.20.40.7
One hour access (0.3 mA shock)0.10.10.20.2-0.20.5-0.3-0.1-0.4-0.2-0.20.1
Compulsive drug intake0.30.40.90.0-0.60.6-1.0-0.4-0.3-0.9-0.5-0.8
One hour access (shock baseline)0.10.10.30.00.5-0.60.40.30.00.30.10.1
Social response proportion0.20.31.2-1.1-0.10.8-0.50.20.3-0.20.5-0.0
Social responses0.20.30.70.7-0.50.5-0.3-0.00.2-0.8-0.6-0.8
Social time1.21.74.2-1.0-1.62.1-1.6-1.0-1.1-1.4-0.7-0.2
Soleus weight1.02.85.32.32.1-0.61.02.21.71.52.00.9
Bone: stiffness0.60.93.31.81.4-0.61.00.90.80.40.10.3
Tibialis anterior weight2.06.830.15.52.9-2.41.52.81.50.91.8-0.9
Time to tail flick, vehicle, before self-admin0.30.31.3-0.5-0.41.1-0.20.20.6-0.10.50.8
Time to tail flick, vehicle, after self-admin1.21.64.10.3-0.02.0-0.41.41.40.71.61.7
Time to tail flick, test, before self-admin0.60.62.5-0.6-0.51.6-1.3-0.2-0.5-0.6-0.00.4
Time to tail flick, test, after self-admin0.10.10.30.3-0.20.40.20.10.30.20.30.5
Delta time to tail flick, vehicle, before/after SA1.71.62.71.21.2-0.10.91.61.61.61.41.0
Delta time to tail flick, test, before/after SA0.40.41.50.70.2-0.91.20.20.50.60.20.2
Tibia length0.20.64.12.00.40.5-0.50.7-0.1-0.40.30.2
Ambulatory time before self-admin0.30.51.1-0.2-0.61.1-0.31.00.80.31.00.3
Ambulatory time after self-admin0.60.72.9-0.6-0.31.20.20.40.40.60.71.7
Bone: tissue strength0.60.61.41.20.9-1.01.0-0.00.40.8-0.00.3
Total heroin consumption0.70.81.9-0.2-0.80.1-1.0-1.2-1.4-0.7-1.0-0.8
Bone: trabecular number0.40.71.8-0.9-1.11.3-1.1-0.6-0.6-0.7-0.20.2
Bone: trabecular spacing0.30.41.10.1-0.3-0.0-0.4-0.7-0.9-0.7-1.1-0.7
Bone: trabecular thickness0.10.20.80.10.0-0.8-0.0-0.20.1-0.2-0.0-0.9
Bone: trabecular tissue density0.20.20.8-0.40.3-0.9-0.1-0.4-0.4-0.3-0.3-0.7
Water consumed over 24 hours0.50.61.90.2-0.6-1.10.2-0.7-0.9-0.5-0.8-1.4
Number of responses in last shaping day4.44.97.11.02.5-1.02.12.62.62.62.71.9