Dclk3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Dclk3	0.28	0.1	2.1e-15	0.1	0.11	0.11	0.12	4.9e-11	3.4e-12	2.8e-12	5.2e-13
2	pVTA	gene expression	Dclk3	0.49	0.25	0.0e+00	0.21	0.21	0.22	0.22	1.3e-16	1.1e-16	3.1e-17	2.7e-17
3	NAcc	mRNA stability	Dclk3	0.02	0.02	2.7e-04	0.03	0.02	0.02	0.03	2.8e-05	1.8e-04	4.4e-04	7.2e-05
4	IL	gene expression	Dclk3	0.29	0.17	5.9e-04	0.14	0.12	0.17	0.13	2.5e-04	7.8e-04	8.7e-05	5.5e-04
5	Liver	gene expression	Dclk3	0.68	0.09	0.0e+00	0.22	0.37	0.37	0.38	5.1e-24	1.1e-43	1.5e-42	2.5e-44
6	RMTg	gene expression	Dclk3	0.35	0.21	1.3e-04	-0.01	0.02	0.02	0.03	5.7e-01	7.5e-02	1.2e-01	7.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.1	0.2	0.6	-0.4	0.2	0.2	0.7	-0.4	0.8
Area under the delay curve	1.4	1.6	2.3	1.3	-1.3	-1.4	1.4	-1.5	-0.5
BMI with tail	0.4	1.3	3.1	-1.7	0.9	0.9	-1.7	-0.0	-0.1
BMI without tail	0.5	1.5	2.7	-1.6	1.3	1.2	-1.2	0.6	1.1
Body weight	5.0	21.8	27.5	-5.2	5.1	5.0	-5.2	3.8	3.1
Weight adjusted by age	0.1	0.1	0.4	-0.2	0.1	0.1	-0.6	-0.0	-0.6
Bone surface	0.1	0.2	0.6	-0.1	-0.4	-0.4	0.3	-0.8	-0.3
Bone volume	0.1	0.2	0.6	-0.4	-0.1	-0.2	0.4	-0.7	0.1
Breakpoint value in progressive ratio session	0.3	0.3	0.7	0.1	-0.5	-0.5	0.8	-0.8	-0.2
Number of licking bursts	0.2	0.3	1.0	0.5	-0.5	-0.4	-0.2	0.1	-1.0
Context. condit. distance diff. score	0.0	0.1	0.1	-0.3	0.0	0.0	-0.1	-0.4	-0.3
Locomotion velocity, session 1	0.2	0.2	0.3	0.5	-0.4	-0.5	0.6	-0.2	0.0
Locomotion distance, session 1	0.6	0.8	1.6	-1.3	1.0	0.7	-0.4	0.1	1.3
Locomotion velocity, session 2	0.5	0.5	1.5	-0.0	-0.6	-0.7	0.7	-1.2	-0.6
Locomotion distance, session 2	0.2	0.3	0.7	-0.4	-0.0	-0.3	0.6	-0.8	0.6
Locomotion velocity, session 3	0.4	0.5	1.0	-1.0	0.3	0.0	0.5	-0.9	0.8
Locomotion distance, session 3	1.2	1.3	5.0	-0.5	-0.7	-0.9	1.2	-2.2	-0.1
Stereotopy head waving bouts, day 3	0.7	0.8	2.5	0.3	0.0	0.1	-1.6	1.1	-1.2
Stereotopy head waving duration, day 3	0.9	1.0	3.0	0.4	0.4	0.5	-1.6	1.7	-0.3
Locomotion velocity, session 7	0.6	0.6	2.2	-0.8	0.7	0.7	-0.1	0.1	1.5
Locomotion distance, session 7	0.2	0.3	0.6	0.5	-0.6	-0.6	0.4	-0.8	0.2
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	0.2	-0.4	-0.4	0.5	-0.6	0.3
Stereotopy head waving duration, day 7	0.2	0.2	0.7	-0.6	0.3	0.2	0.1	-0.2	0.8
Locomotion velocity, session 8	0.6	0.8	2.6	-1.6	0.6	0.3	0.1	-1.0	0.6
Locomotion distance, session 8	0.4	0.6	1.5	-1.2	0.6	0.3	0.0	-0.8	1.1
Degree of sensitization distance	1.6	1.6	4.8	0.0	1.1	1.2	-1.2	2.2	0.9
Degree of sensitization stereotypy	0.4	0.5	1.0	-0.1	-0.2	-0.3	1.0	-0.9	0.9
Conditioned locomotion	3.0	3.4	5.4	1.8	-2.0	-1.9	2.3	-1.8	-1.1
Cocaine response after cond. corrected	0.8	1.0	3.0	0.2	0.4	0.5	-1.7	1.4	-0.6
Cocaine response after cond. not corrected	1.7	2.0	4.7	-0.9	1.3	1.3	-2.2	1.9	0.2
Cocaine response before conditioning	1.0	1.2	3.1	-1.7	1.2	1.0	-0.2	0.1	1.2
Saline control response	0.8	1.1	2.1	-0.3	0.9	1.0	-0.7	1.4	1.4
Bone: connectivity density	0.4	0.6	1.4	0.8	-0.7	-0.6	1.2	-0.6	0.2
Bone: cortical apparent density	0.4	0.6	1.6	0.3	-0.7	-0.7	1.3	-1.0	-0.1
Bone: cortical area	0.2	0.2	1.0	-0.3	-0.3	-0.2	0.1	-0.5	-1.0
Bone: cortical porosity	0.5	0.6	1.5	0.8	-0.3	-0.3	1.2	-0.1	1.0
Bone: cortical porosity	0.5	0.6	1.3	0.9	-0.2	-0.2	1.2	0.2	1.0
Bone: cortical thickness	0.3	0.4	1.3	-1.1	0.5	0.5	-0.6	-0.1	-0.6
Bone: cortical thickness	0.0	0.0	0.1	-0.2	0.1	0.1	0.1	-0.1	0.1
Bone: cortical tissue density	0.5	0.7	1.8	0.3	-0.7	-0.7	1.3	-1.1	-0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	0.0	0.3	0.4	-0.2	0.7	0.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.1	-0.1	0.5	0.6	-0.6	1.0	0.1
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	-0.3	-0.2	0.3	-0.0	-0.3
Condit. Reinf. inactive responses	0.8	0.9	1.5	0.6	-1.0	-1.0	1.1	-1.2	-0.6
Incentive salience index mean	0.0	0.0	0.1	0.3	-0.3	-0.2	0.2	-0.1	-0.3
Condit. Reinf. lever presses	1.0	1.4	1.9	1.0	-1.3	-1.4	1.1	-1.4	-1.0
Condit. Reinf. active minus inactive responses	1.4	1.9	3.3	-1.8	1.5	1.4	-1.6	0.8	0.7
Condit. Reinf. active-inactive response ratio	1.4	1.6	3.2	-1.2	1.3	1.3	-1.8	1.2	0.4
Condit. Reinf. active responses	1.1	1.5	2.9	-1.3	1.3	1.2	-1.7	1.2	0.4
Condit. Reinf. inactive responses	0.1	0.2	0.5	0.4	-0.5	-0.5	-0.1	-0.1	-0.7
Condit. Reinf. lever presses	1.9	2.7	3.8	-2.0	1.7	1.7	-2.0	1.1	1.1
Condit. Reinf. lever reinforcers received	1.5	2.0	3.3	-1.5	1.5	1.5	-1.8	1.4	0.6
Conditioned reinforcement - actives	1.5	2.6	4.2	2.1	-1.7	-2.0	1.3	-0.7	-1.5
Conditioned reinforcement - inactives	2.1	3.0	6.7	1.8	-1.8	-1.9	0.5	-1.0	-2.6
Conditioned locomotion	0.9	1.1	3.4	1.9	-0.8	-1.0	1.1	0.6	-0.1
Patch foraging indifference point 0 sec	1.1	1.9	3.8	-1.4	1.5	1.5	-0.2	1.1	2.0
Patch foraging indifference point AUC	0.5	0.7	1.5	-0.6	0.3	0.2	1.2	-0.8	1.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.2	0.3	0.4	-0.3	0.0	0.3
Delay disc. indifference point, 16s delay	0.8	0.9	1.1	1.0	-1.0	-1.0	0.9	-1.0	-0.4
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	0.6	-0.5	-0.6	0.8	-0.7	-0.3
Delay disc. indifference point, 24s delay	1.1	1.2	1.9	1.4	-1.2	-1.3	1.0	-0.9	-0.6
Delay disc. indifference point, 4s delay	1.5	1.6	2.2	1.2	-1.3	-1.4	1.2	-1.5	-0.9
Delay disc. indifference point, 8s delay	1.3	1.5	2.3	1.3	-1.3	-1.3	1.2	-1.5	-0.6
Indifference point function ln k	0.2	0.4	1.1	0.0	-0.6	-0.7	-0.4	-0.5	-1.0
Indifference point function log k	0.2	0.4	1.1	0.0	-0.6	-0.7	-0.4	-0.5	-1.0
Patch foraging total patch changes 0 sec	1.1	2.1	3.3	-1.5	1.6	1.6	-0.5	1.3	1.8
Patch foraging total patch changes 12 sec	0.5	0.7	1.6	-0.7	0.9	0.7	0.2	0.8	1.3
Patch foraging total patch changes 18 sec	2.1	3.2	6.9	-1.7	2.0	1.8	0.5	1.4	2.6
Patch foraging total patch changes 24 sec	1.5	2.6	3.4	-1.8	1.9	1.7	-0.8	1.5	1.8
Patch foraging total patch changes 6 sec	0.3	0.5	2.0	-0.2	0.5	0.4	0.6	0.3	1.4
Patch foraging time to switch 0 sec	0.4	0.8	1.5	1.2	-0.9	-1.0	0.4	0.1	-1.1
Patch foraging water rate 0 sec	0.2	0.5	0.9	-1.0	0.8	0.8	-0.4	0.3	0.5
Patch foraging water rate 12 sec	0.3	0.6	1.8	-0.6	0.6	0.7	-1.3	0.9	0.2
Patch foraging water rate 18 sec	0.7	1.1	2.8	-1.3	0.8	1.0	-1.7	0.1	-0.6
Patch foraging water rate 24 sec	0.8	1.1	1.9	-1.4	1.1	1.3	-1.0	0.7	0.7
Patch foraging water rate 6 sec	0.4	0.6	1.6	-1.3	0.8	0.7	0.0	0.1	0.9
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	2.3	1.5	-0.9	-0.7	0.4	-0.9	-0.5
Distance traveled before self-admin	0.3	0.3	1.4	0.2	-0.3	-0.1	-0.6	0.2	-1.2
Distance traveled after self-admin	0.5	0.6	1.1	0.6	-0.9	-1.0	0.5	-0.3	-0.9
Extensor digitorum longus weight	0.1	0.5	1.4	0.8	-0.7	-0.6	-0.4	-0.3	-1.2
Bone: elastic displacement	0.1	0.1	0.2	-0.5	0.2	0.2	-0.1	0.1	-0.4
Bone: elastic work	0.5	0.7	2.9	-1.7	0.7	0.6	-0.4	-0.3	-0.1
Bone: endosteal estimation	0.1	0.3	0.6	-0.2	0.5	0.6	-0.1	0.5	0.8
Bone: endosteal perimeter	0.8	1.7	2.2	1.3	-1.5	-1.4	1.1	-1.2	-1.2
Epididymis fat weight	0.5	1.6	2.6	-1.6	1.5	1.6	-1.3	0.6	0.8
Delta time in closed arm before/after self-admin	0.1	0.0	0.1	0.2	-0.2	0.1	-0.3	-0.3	-0.0
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.1	0.1	-0.2	0.5	0.2	0.6
Diff in mean of infusions in LGA sessions	0.4	0.5	1.5	-0.1	-0.1	-0.0	-1.2	0.4	-1.0
Delay discount exponential model param	1.6	1.8	2.5	-1.4	1.4	1.5	-1.4	1.6	0.6
Extinction: sum of active levers before priming	0.2	0.2	0.8	-0.2	0.4	0.6	-0.0	0.2	0.9
Active lever presses in extinction session 6	0.5	0.5	1.0	-0.3	0.6	0.8	-0.7	1.0	0.7
Bone: final force	1.0	1.6	3.4	-1.8	1.4	1.4	-1.3	0.7	0.5
Bone: final moment	1.2	1.9	3.9	-2.0	1.5	1.5	-1.5	0.8	0.5
Food consumed during 24 hour testing period	1.2	1.7	2.4	-1.1	1.3	1.4	-1.6	1.5	0.7
Glucose	0.7	1.1	2.3	-1.1	1.1	1.0	-0.4	0.7	1.5
Heart weight	2.3	3.6	7.5	-1.9	1.9	1.9	-2.7	1.7	0.2
Delay discount hyperbolic model param	1.9	2.1	2.6	-1.5	1.5	1.6	-1.5	1.6	0.8
Intermittent access intake day 1-15 change	0.5	1.1	2.5	1.2	-1.1	-1.1	-0.2	-0.3	-1.6
Intermittent access intake escalation	0.8	1.6	3.5	1.4	-1.3	-1.4	-0.1	-0.4	-1.9
Intermittent access intake escalation 2	0.7	0.8	2.2	0.9	-0.6	-0.7	-0.9	0.5	-1.5
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.7	0.2	-0.3	-0.2	-0.4	-0.1	-0.8
Intermitt. access day 15 inactive lever presses	1.2	2.5	4.6	0.6	-1.6	-1.6	0.8	-2.0	-2.2
Intermitt. access escalation Index	0.3	0.4	1.3	-0.7	0.4	0.6	0.3	-0.5	1.1
Intermittent access day 1 total infusions	0.1	0.2	0.5	0.5	-0.4	-0.4	0.7	-0.4	-0.4
Intermittent access day 15 total infusions	1.0	1.4	2.6	1.5	-1.3	-1.3	0.4	-0.6	-1.6
Intermittent access terminal intake (last 3 days)	0.8	1.0	2.0	1.4	-1.0	-1.0	0.6	-0.4	-1.2
Intermittent access total infusions	1.0	1.2	2.1	1.2	-1.1	-1.1	0.6	-0.7	-1.5
Intermittent access day 1 locomotion	0.3	0.4	1.1	0.9	-0.0	-0.2	0.6	1.1	0.5
Intermittent access day 15 total locomotion	0.5	0.9	2.6	1.6	-0.8	-1.0	0.8	0.5	-0.6
Intermittent access total locomotion	1.0	1.2	2.7	1.7	-1.1	-1.2	1.3	-0.1	-0.6
Intermittent access standard deviation	0.4	0.8	2.5	0.5	-0.6	-0.8	-0.8	0.6	-1.6
Left kidney weight	0.7	3.1	4.0	-1.4	2.0	2.0	-2.0	1.7	1.4
Right kidney weight	0.5	2.4	5.4	-0.8	1.6	1.6	-2.3	1.6	1.0
Cocaine induced anxiety	0.0	0.1	0.1	0.2	-0.1	-0.3	0.1	0.3	-0.3
Post-drug Anxiety	0.2	0.2	0.3	0.6	-0.4	-0.6	0.5	-0.0	-0.4
Baseline Anxiety	0.0	0.0	0.1	0.2	-0.1	-0.1	0.2	-0.3	0.2
Tail length	3.6	14.2	18.0	-3.5	4.2	4.1	-3.0	3.9	3.7
Length with tail	7.7	33.5	40.7	-5.6	6.4	6.4	-6.1	5.8	4.2
Length without tail	7.9	25.3	36.4	-4.9	5.5	5.6	-6.0	4.7	2.8
Times rat made contact with spout	0.5	0.5	1.3	-0.0	0.6	0.6	-1.0	1.1	0.3
Lifetime Intake	1.3	1.6	2.3	1.5	-1.4	-1.4	1.1	-0.7	-1.3
Liver weight, left	0.4	0.7	1.2	-0.9	1.0	1.0	-0.0	0.6	1.1
Liver weight, right	1.6	2.8	4.1	-1.2	1.9	2.0	-1.8	1.7	1.4
Locomotor activity	4.9	7.6	9.1	-2.8	3.0	2.8	-2.5	3.0	2.3
Locomotor testing distance	3.5	6.3	10.4	-2.3	2.6	2.4	-2.4	3.2	2.0
Locomotor testing rearing	0.3	0.6	2.5	0.1	0.5	0.5	-0.7	1.6	0.3
Locomotion in novel chamber	0.2	0.2	0.7	0.2	-0.4	-0.4	-0.4	-0.4	-0.9
Locomotion in novel chamber post-restriction	0.4	0.7	1.4	-1.0	0.9	0.8	-0.2	0.2	1.2
Fecal boli incidents, locomotor time 1	0.5	0.7	1.2	-1.1	1.0	1.1	-0.9	0.2	0.4
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.1	0.0	0.0	0.2	-0.1	0.1
Time >=10cm from walls, locomotor time 1	0.5	0.6	2.7	0.4	-0.4	-0.4	1.6	-0.4	0.2
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.1	0.1	0.0	-0.6	0.1	0.0
Total resting periods, locomotor time 1	0.1	0.1	0.4	-0.2	0.1	0.1	-0.7	0.1	0.0
Rest time, locomotor task time 1	0.2	0.3	0.6	0.8	-0.4	-0.2	-0.6	-0.3	-0.4
Distance moved, locomotor task time 1	0.5	0.7	2.2	-1.5	0.9	0.8	0.0	0.6	0.5
Vertical activity count, locomotor time 1	0.2	0.4	1.0	-1.0	0.6	0.5	0.7	0.5	0.5
Time >=10cm from walls, locomotor time 2	1.1	1.6	2.7	-1.6	1.4	1.5	-0.8	0.7	1.2
Bouts of movement, locomotor time 2	0.1	0.2	0.9	-0.9	0.2	0.2	-0.3	-0.2	-0.3
Total resting periods, locomotor time 2	0.1	0.2	0.6	-0.8	0.0	0.1	-0.2	-0.5	-0.3
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.3	0.1	0.2	-0.1	-0.6	0.3
Distance moved, locomotor task time 2	0.4	0.5	1.2	-0.5	0.6	0.5	-0.8	1.1	0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.4	0.4	-0.1	-0.3	0.2	0.6	-0.1
Light reinforcement 1	0.2	0.6	0.8	-0.8	0.7	0.7	-0.4	0.8	0.9
Light reinforcement 2	0.1	0.1	0.4	-0.1	-0.2	-0.2	0.3	-0.7	0.3
Bone: marrow area	0.1	0.3	0.7	-0.3	0.6	0.6	-0.1	0.5	0.8
Bone: maximum diameter	0.3	0.6	1.3	0.4	-0.8	-0.8	0.4	-0.8	-1.2
Bone: maximum force	0.7	1.2	2.5	-1.6	1.2	1.2	-1.0	0.6	0.8
Bone: maximum moment	0.8	1.4	2.7	-1.6	1.3	1.3	-1.1	0.8	0.7
Mean time between licks in bursts	0.6	1.4	2.7	1.4	-1.3	-1.3	0.4	-0.6	-1.7
Mean num. licks in bursts	0.4	0.6	1.5	-0.5	0.8	0.8	-0.4	0.7	1.2
Cd content in liver	0.1	0.1	0.3	0.6	-0.4	-0.5	0.2	0.0	0.0
Co content in liver	0.8	0.9	1.7	1.1	-1.1	-0.9	0.5	-0.7	-1.3
Cu content in liver	2.9	3.5	6.2	-2.5	2.1	2.0	-1.0	1.4	1.7
Fe content in liver	0.9	1.0	1.6	-1.1	1.2	1.3	-0.7	1.0	0.7
K content in liver	0.6	0.6	1.6	-1.3	0.2	0.0	0.8	-0.9	0.5
Mg content in liver	1.2	1.2	3.9	-0.2	-0.9	-1.1	1.1	-2.0	-0.6
Mn content in liver	0.5	0.5	1.5	-1.0	0.1	-0.1	0.2	-1.2	0.7
Na content in liver	0.4	0.4	0.8	-0.9	0.5	0.6	0.7	0.2	0.8
Rb content in liver	0.8	1.0	3.1	-0.0	0.9	1.2	-0.5	1.8	0.5
Se content in liver	0.2	0.3	0.8	-0.8	-0.0	-0.2	0.1	-0.9	-0.2
Sr content in liver	0.4	0.4	1.3	-0.7	-0.1	-0.4	0.0	-1.2	0.0
Zn content in liver	1.9	2.1	3.5	-1.9	1.6	1.5	-0.9	1.0	1.6
Bone: minimum diameter	0.2	0.4	0.7	0.5	-0.7	-0.7	0.3	-0.7	-0.9
Time in familiar zone, hab. session 1	0.9	0.9	2.2	1.5	-1.0	-0.8	-0.0	-0.1	-1.2
Time in novel zone, hab. session 1	0.2	0.2	0.6	-0.1	0.3	0.1	-0.6	0.8	0.3
Total zone transitions, hab. session 1	0.5	0.7	1.4	-1.0	0.8	0.5	-0.8	0.2	1.2
Total locomotion distance, hab. session 1	0.2	0.3	0.6	-0.8	0.5	0.4	-0.7	0.0	0.6
Locomotion velocity, hab. session 1	0.3	0.5	1.1	-1.1	0.6	0.4	-0.3	-0.3	1.0
Time in familiar zone, hab. session 2	0.4	0.4	1.1	0.4	-0.6	-0.6	-0.0	-0.6	-1.0
Time in novel zone, hab. session 2	0.2	0.2	0.8	0.6	0.1	0.1	0.3	0.9	0.4
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.5	0.2	0.0	-0.3	-0.2	0.3
Total locomotion distance, hab. session 2	0.3	0.4	1.4	-1.2	0.5	0.4	0.2	-0.4	0.7
Locomotion velocity, hab. session 2	0.3	0.4	1.3	-1.1	0.4	0.3	0.3	-0.7	0.7
Novel to familiar place preference ratio	1.4	1.6	5.3	-0.8	1.1	1.1	0.6	0.7	2.3
Novelty place preference	1.5	1.6	5.6	-0.7	1.1	1.1	0.7	0.7	2.4
Time in novel zone, NPP test	1.6	1.7	5.4	-0.6	1.2	1.2	0.3	1.1	2.3
Total zone transitions, NPP test	1.9	2.7	4.4	-2.1	1.8	1.5	-1.4	0.8	1.9
Total locomotion distance, NPP test	0.9	1.2	2.7	-1.6	1.2	1.0	-0.9	0.2	1.0
Locomotion velocity, NPP test	1.0	1.4	3.6	-1.9	1.2	1.1	-0.7	-0.0	1.2
Intraocular pressure	1.2	1.8	4.2	-0.2	1.2	1.5	-1.1	2.1	1.3
Delta distance traveled before/after self-admin	0.2	0.2	0.6	-0.0	-0.2	-0.4	0.7	-0.4	0.4
Delta ambulatory time before/after self-admin	0.3	0.4	1.2	-0.5	0.5	0.3	0.1	0.6	1.1
Parametrial fat weight	0.4	0.9	2.7	-1.6	1.0	0.8	-0.3	0.2	0.9
Pavlov. Cond. lever latency	3.4	4.3	8.4	-1.1	2.2	2.2	-1.8	2.9	1.8
Pavlov. Cond. magazine entry latency	6.2	7.9	10.3	2.2	-3.1	-3.1	2.5	-3.2	-2.6
Pavlov. Cond. change in total contacts	1.3	1.4	2.8	0.4	-1.1	-1.0	1.5	-1.7	-0.9
Pavlov. Cond. index score	5.2	6.5	9.4	1.8	-2.8	-2.8	2.3	-3.1	-2.4
Pavlov. Cond. latency score	4.9	6.2	10.1	1.6	-2.7	-2.7	2.2	-3.2	-2.3
Pavlov. Cond. lever contacts	2.3	2.8	5.8	0.6	-1.7	-1.7	1.6	-2.4	-1.4
Pavlov. Cond. magazine entry number	6.1	7.7	9.5	-2.4	3.1	3.1	-2.5	2.9	2.6
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	-0.3	0.7	0.7	-0.2	0.9	0.5
Pavlov. Cond. lever-magazine prob. diff.	4.7	5.8	8.2	1.6	-2.6	-2.6	2.0	-2.9	-2.5
Pavlov. Cond. response bias	5.5	6.8	8.7	2.0	-2.9	-2.9	2.3	-2.9	-2.6
Pavlov. Cond. lever latency	0.7	1.0	1.8	1.3	-1.1	-1.0	1.1	-0.5	-0.7
Pavlov. Cond. magazine entry latency	0.2	0.2	0.7	-0.4	-0.3	-0.4	0.1	-0.8	-0.3
Pavlov. Cond. change in total contacts	2.0	3.3	4.8	-2.2	2.0	1.9	-2.0	1.4	1.2
Pavlov. Cond. index score	0.3	0.4	1.4	-1.2	0.6	0.5	-0.6	-0.2	0.2
Pavlov. Cond. latency score	0.2	0.3	1.2	-1.1	0.4	0.3	-0.5	-0.3	0.1
Pavlov. Cond. lever contacts	0.9	1.2	1.9	-1.4	1.2	1.2	-1.0	0.6	1.0
Pavlov. Cond. magazine entry number	0.1	0.2	0.5	0.2	0.3	0.4	-0.2	0.7	0.3
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.7	1.3	-0.9	-0.8	0.8	-0.2	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.2	-1.1	0.5	0.4	-0.7	-0.2	0.1
Pavlov. Cond. response bias	0.2	0.2	0.8	-0.9	0.5	0.4	-0.5	-0.1	0.2
Time in closed arm before self-admin	0.6	0.7	1.2	-0.8	1.1	0.9	-0.6	1.0	0.7
Time in closed arm after self-admin	0.1	0.1	0.6	0.3	0.0	0.1	-0.8	0.1	-0.4
Time in open arm before self-admin	0.5	0.5	1.2	1.1	-0.9	-0.6	0.2	-0.4	-0.9
Time in open arm after self-admin	1.1	1.2	4.0	0.7	-0.7	-1.0	2.0	-0.8	0.7
Bone: periosteal estimation	0.0	0.1	0.3	-0.5	0.3	0.3	-0.2	0.0	0.0
Bone: periosteal perimeter	0.7	1.2	1.6	0.7	-1.2	-1.1	1.2	-1.3	-1.1
Bone: post-yield work	0.1	0.1	0.3	-0.0	0.1	0.1	-0.5	0.3	0.2
Progressive ratio test 1 active lever presses	0.1	0.2	0.6	0.4	0.1	0.0	0.7	0.2	0.5
Progressive ratio test 1 breakpoint	0.2	0.2	0.6	0.4	0.1	0.0	0.8	0.2	0.5
Progressive ratio test 1 inactive lever presses	0.7	1.0	2.2	1.1	-0.9	-1.1	0.5	-0.1	-1.5
Progressive ratio test 2 active lever presses	1.8	2.1	3.4	1.8	-1.6	-1.6	1.0	-0.7	-1.5
Progressive ratio test 2 breakpoint	1.8	2.1	3.3	1.8	-1.6	-1.6	0.9	-0.8	-1.6
Progressive ratio test 2 inactive lever presses	2.0	3.2	6.8	1.8	-1.9	-1.9	0.8	-1.2	-2.6
Incentive Sensitization - Responses	1.7	2.4	4.6	1.7	-1.8	-1.7	0.4	-0.8	-2.1
Incentive Sensitization - Breakpoint	1.9	2.4	4.7	1.7	-1.8	-1.7	0.4	-0.8	-2.2
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.0	0.5	-0.2	-0.3	1.0	0.0	0.9
Progressive ratio	2.2	3.4	4.5	-1.8	2.0	2.0	-1.5	1.6	2.1
Food seeking constrained by brief footshock	0.5	0.6	1.2	1.1	-0.8	-0.5	-0.3	-0.6	-0.9
Seeking ratio, punishment vs. effort	3.1	4.5	6.7	2.4	-2.4	-2.2	1.1	-1.7	-2.6
Retroperitoneal fat weight	1.3	5.4	8.7	-2.9	2.6	2.5	-2.3	1.5	1.8
Reaction time number correct	0.2	0.5	1.2	1.1	-0.7	-0.6	0.2	0.2	-0.8
Reaction time mean minus median	0.0	0.1	0.2	0.1	-0.1	-0.2	0.0	0.4	0.3
Reaction time mean minus median AUC	0.1	0.3	0.8	-0.1	0.4	0.3	-0.2	0.9	0.8
Reaction time num false alarms	0.2	0.2	0.8	0.9	-0.4	-0.4	0.5	0.1	0.1
Reaction time num false alarms AUC	0.1	0.2	0.5	0.7	-0.2	-0.2	0.5	0.3	0.4
Reaction time trials correct on left	0.2	0.5	1.2	1.1	-0.7	-0.6	0.2	0.2	-0.8
Reaction time trials on left	0.3	0.5	1.4	1.2	-0.7	-0.7	0.3	0.2	-0.8
Reaction time mean	0.0	0.0	0.1	0.0	-0.1	-0.1	0.3	0.3	0.2
Reaction time mean AUC	0.0	0.1	0.2	0.1	-0.1	-0.1	0.5	0.2	0.4
Median of all reaction times	0.0	0.0	0.2	0.0	-0.1	-0.1	0.4	0.1	0.1
Reaction time omissions	0.7	1.0	2.8	1.7	-0.6	-0.5	1.4	0.8	0.2
Reaction time false alarm rate	0.1	0.1	0.3	0.2	-0.0	0.0	0.3	0.0	0.6
Reaction time premature initiation rate	0.8	1.1	1.6	-1.3	1.2	1.0	-0.2	1.1	1.2
Reaction time premature initiations	0.3	0.4	1.1	-0.7	0.7	0.6	-0.2	1.0	0.6
Std. dev. reaction times	0.1	0.2	0.8	0.0	0.2	0.1	0.2	0.7	0.9
Reaction time trials completed	0.3	0.5	1.4	1.2	-0.7	-0.7	0.3	0.2	-0.8
Reaction time trials AUC	0.3	0.6	1.7	1.3	-0.8	-0.7	0.2	0.2	-0.9
Run reversals in cocaine runway, females	1.1	1.1	1.6	0.6	-1.2	-1.1	0.9	-1.1	-1.3
Run reversals in cocaine runway, males	0.2	0.2	1.0	0.4	-0.1	-0.3	-0.1	1.0	-0.4
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	0.3	-0.0
Latency to leave start box in cocaine runway, F	0.4	0.4	1.2	-0.4	0.4	0.3	-1.1	0.9	-0.5
Latency to leave start box in cocaine runway, M	1.0	0.9	2.1	0.7	-0.8	-0.9	1.4	-1.3	0.0
Std. dev. time between licks in bursts	2.4	3.2	6.2	1.8	-2.0	-1.9	0.6	-1.3	-2.5
Total sessions with >9 infusions	0.8	0.9	2.0	1.4	-0.9	-0.8	0.6	0.4	-1.2
Short access day 1 total inactive lever presses	1.8	2.4	2.9	1.7	-1.7	-1.6	1.4	-1.3	-1.6
Short access day 10 total inactive lever presses	0.2	0.4	1.2	-0.1	0.1	0.2	-1.0	0.5	-1.1
Short access day 1 total infusions	2.4	3.1	4.4	2.1	-1.9	-1.8	1.9	-1.2	-1.5
Short access day 10 total infusions	0.9	1.1	1.5	1.2	-1.1	-0.9	1.0	-1.1	-1.0
Short access total infusions	2.3	2.9	4.4	2.1	-1.8	-1.8	1.9	-1.1	-1.3
Short access day 1 locomotion	0.8	1.0	2.5	1.6	-1.0	-1.0	1.0	0.3	-0.8
Short access day 10 total locomotion	0.1	0.2	0.6	0.0	0.3	0.3	0.6	0.3	0.8
Short access total locomotion	0.5	0.6	1.6	1.3	-0.3	-0.3	1.0	0.8	0.3
One hour access (0.3 mA shock)	0.4	0.5	1.7	1.3	-0.5	-0.6	0.6	0.3	-0.1
Compulsive drug intake	0.6	0.7	1.4	0.9	-0.8	-0.8	1.2	-0.7	0.2
One hour access (shock baseline)	0.3	0.5	1.0	1.0	-0.6	-0.7	0.1	0.1	-0.9
Social response proportion	0.2	0.2	0.5	0.1	0.1	0.1	0.7	0.6	0.5
Social responses	0.3	0.4	0.9	-0.7	0.6	0.6	0.2	0.3	1.0
Social time	1.5	2.0	4.7	1.5	-1.4	-1.6	-0.4	-0.0	-2.2
Soleus weight	3.5	10.2	13.3	-3.5	3.6	3.6	-2.9	2.8	2.7
Bone: stiffness	0.2	0.3	0.4	-0.6	0.6	0.6	-0.6	0.3	0.5
Tibialis anterior weight	0.1	0.4	1.5	-0.4	0.4	0.4	-1.2	0.5	-0.6
Time to tail flick, vehicle, before self-admin	2.1	2.2	2.9	-1.1	1.6	1.7	-1.6	1.6	1.3
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.3	0.0	-0.2	0.0	-0.2	-0.2
Time to tail flick, test, before self-admin	0.2	0.2	0.4	0.6	-0.2	-0.1	0.6	0.0	0.5
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.1	-0.3	-0.4	0.3	-0.5	-0.6
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	2.1	0.3	-1.1	-1.3	1.1	-1.4	-0.9
Delta time to tail flick, test, before/after SA	0.1	0.1	0.5	-0.6	0.1	0.0	0.1	-0.7	-0.3
Tibia length	5.6	15.4	26.0	-5.1	4.5	4.3	-3.1	2.7	3.2
Ambulatory time before self-admin	0.3	0.4	1.8	0.3	-0.5	-0.2	-0.5	-0.3	-1.3
Ambulatory time after self-admin	0.1	0.1	0.2	0.2	-0.3	-0.4	0.3	-0.1	-0.2
Bone: tissue strength	2.8	2.9	5.3	-2.3	1.9	1.9	-1.6	1.2	0.9
Total heroin consumption	1.2	1.5	2.3	-1.5	1.2	1.1	-1.3	1.4	0.2
Bone: trabecular number	0.5	0.8	1.6	0.9	-0.9	-0.9	1.3	-1.0	-0.0
Bone: trabecular spacing	1.3	1.8	3.4	-1.3	1.3	1.4	-1.9	1.3	0.3
Bone: trabecular thickness	0.4	0.5	0.9	-0.8	0.2	0.1	1.0	-0.8	0.9
Bone: trabecular tissue density	0.2	0.3	0.6	-0.5	0.6	0.4	-0.7	0.4	0.7
Water consumed over 24 hours	0.3	0.4	1.7	-0.1	0.1	0.1	-1.3	0.4	-0.8
Number of responses in last shaping day	0.7	0.8	2.8	-0.2	-0.0	0.2	-1.7	-0.2	-1.4