Dclk3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Dclk3	0.29	0.1	1.7e-16	0.1	0.12	0.12	0.13	1.4e-11	4.8e-13	8.9e-14	5.1e-14
2	NAcc	mRNA stability	Dclk3	0.03	0.02	4.9e-04	0.03	0.01	0.01	0.03	5.1e-04	1.0e-02	2.4e-02	4.4e-04
3	RMTg	gene expression	Dclk3	0.18	0.12	1.7e-03	0.02	0.04	0.02	0.04	1.2e-01	3.7e-02	1.1e-01	2.3e-02
4	pVTA	gene expression	Dclk3	0.57	0.19	1.0e-07	0.17	0.15	0.16	0.16	7.5e-08	5.1e-07	2.7e-07	3.0e-07
5	IL	gene expression	Dclk3	0.28	0.15	2.9e-04	0.11	0.1	0.1	0.1	1.6e-03	1.8e-03	2.5e-03	2.3e-03
6	Liver	gene expression	Dclk3	0.68	0.09	0.0e+00	0.23	0.39	0.37	0.39	2.5e-25	4.4e-46	2.4e-43	3.3e-46

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.1	0.2	0.6	-0.4	0.2	0.8	-0.3	0.1	-0.5
Area under the delay curve	1.8	1.9	3.2	1.4	-1.8	-0.9	1.4	-1.0	-1.5
BMI with tail	0.8	2.6	5.9	-2.4	1.0	1.0	-1.4	2.4	-0.1
BMI without tail	1.5	3.1	4.7	-2.1	1.8	1.7	-1.5	2.2	0.9
Body weight	6.3	26.2	37.1	-6.1	5.3	4.7	-5.5	5.6	3.1
Weight adjusted by age	0.4	0.4	0.9	-0.7	0.6	-0.0	-0.8	1.0	0.3
Bone surface	0.1	0.2	0.9	-0.3	-0.3	-0.0	0.3	-0.2	-0.9
Bone volume	0.1	0.2	1.0	-0.5	-0.1	0.3	0.1	-0.2	-1.0
Breakpoint value in progressive ratio session	0.1	0.2	0.4	-0.4	0.2	0.5	0.1	0.4	-0.6
Number of licking bursts	0.2	0.2	0.6	0.5	-0.3	-0.8	0.4	-0.1	0.3
Context. condit. distance diff. score	0.0	0.1	0.1	-0.3	0.0	-0.1	-0.0	-0.3	-0.4
Locomotion velocity, session 1	0.1	0.1	0.2	0.4	-0.2	-0.2	0.5	-0.4	-0.3
Locomotion distance, session 1	0.7	0.9	2.0	-1.3	1.0	1.4	-0.7	0.5	-0.3
Locomotion velocity, session 2	0.5	0.6	2.0	-0.1	-0.5	-0.4	0.7	-0.8	-1.4
Locomotion distance, session 2	0.2	0.3	0.8	-0.3	-0.0	0.7	0.1	-0.5	-0.9
Locomotion velocity, session 3	0.6	0.7	1.6	-1.0	0.2	0.9	-0.1	0.8	-1.3
Locomotion distance, session 3	1.4	1.5	6.7	-0.3	-1.0	-0.0	0.9	-0.5	-2.6
Stereotopy head waving bouts, day 3	0.4	0.5	2.0	0.2	0.3	-0.9	-0.2	0.3	1.4
Stereotopy head waving duration, day 3	0.7	0.9	3.9	0.2	0.7	-0.2	-0.6	0.5	2.0
Locomotion velocity, session 7	0.4	0.5	1.6	-0.5	0.6	1.3	-0.7	0.3	0.0
Locomotion distance, session 7	0.5	0.6	1.5	0.8	-0.8	-0.1	0.7	-1.2	-0.6
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	0.4	-0.4	0.2	0.4	-0.1	-0.6
Stereotopy head waving duration, day 7	0.3	0.3	0.7	-0.5	0.4	0.8	-0.3	0.8	-0.3
Locomotion velocity, session 8	0.9	1.1	2.7	-1.6	0.5	1.0	-0.3	0.4	-1.6
Locomotion distance, session 8	0.5	0.8	1.7	-1.2	0.5	1.3	-0.4	0.1	-1.1
Degree of sensitization distance	1.5	1.5	6.0	0.2	1.2	0.6	-1.1	0.3	2.5
Degree of sensitization stereotypy	0.2	0.2	0.8	0.1	-0.2	0.7	0.2	0.1	-0.9
Conditioned locomotion	2.5	2.9	3.7	1.8	-1.9	-1.4	1.8	-1.8	-1.5
Cocaine response after cond. corrected	0.5	0.6	2.5	0.1	0.5	-0.5	-0.4	0.5	1.6
Cocaine response after cond. not corrected	1.5	1.7	3.2	-0.9	1.4	0.4	-1.2	1.7	1.8
Cocaine response before conditioning	1.4	1.7	2.9	-1.7	1.2	1.4	-0.9	1.6	-0.4
Saline control response	1.4	1.9	3.2	-0.7	1.4	1.8	-1.6	0.7	1.6
Bone: connectivity density	0.2	0.3	0.6	0.8	-0.6	0.0	0.5	-0.5	-0.4
Bone: cortical apparent density	0.4	0.6	1.3	0.5	-0.7	-0.3	0.8	-1.0	-1.1
Bone: cortical area	0.2	0.2	0.5	-0.3	-0.4	-0.7	0.3	-0.4	-0.7
Bone: cortical porosity	0.2	0.2	0.8	0.9	-0.2	0.5	0.1	-0.0	0.3
Bone: cortical porosity	0.3	0.3	1.4	1.2	-0.3	0.3	0.2	-0.1	0.5
Bone: cortical thickness	0.2	0.4	1.6	-1.3	0.4	-0.1	-0.5	0.2	-0.5
Bone: cortical thickness	0.0	0.0	0.2	-0.1	0.1	0.1	-0.1	-0.4	0.0
Bone: cortical tissue density	0.5	0.6	1.5	0.4	-0.7	-0.2	0.8	-1.0	-1.2
Condit. Reinf. active minus inactive responses	0.2	0.3	1.2	0.3	0.4	-0.1	-0.4	-0.3	1.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.9	0.2	0.5	-0.1	-0.6	-0.0	1.4
Condit. Reinf. active responses	0.1	0.2	0.4	0.5	-0.2	-0.4	0.2	-0.6	0.3
Condit. Reinf. inactive responses	0.7	0.8	1.4	0.6	-1.0	-0.7	1.0	-0.8	-1.2
Incentive salience index mean	0.1	0.2	0.5	0.5	-0.2	-0.4	0.2	-0.7	0.3
Condit. Reinf. lever presses	1.2	1.6	2.1	1.2	-1.4	-1.1	1.4	-1.5	-1.0
Condit. Reinf. active minus inactive responses	1.6	2.0	4.0	-2.0	1.6	1.4	-1.6	0.8	0.5
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.6	-1.3	1.2	0.8	-1.2	1.2	1.0
Condit. Reinf. active responses	1.1	1.6	2.5	-1.5	1.6	1.0	-1.5	0.4	1.0
Condit. Reinf. inactive responses	0.2	0.2	1.0	0.2	-0.0	-0.4	0.1	-1.0	0.1
Condit. Reinf. lever presses	2.0	2.6	4.8	-2.2	1.8	1.6	-1.9	1.0	0.8
Condit. Reinf. lever reinforcers received	1.4	2.0	3.0	-1.7	1.7	1.2	-1.7	0.7	1.2
Conditioned reinforcement - actives	0.6	0.6	1.7	1.3	-0.3	-0.6	0.7	-0.8	0.8
Conditioned reinforcement - inactives	1.0	1.1	3.2	1.1	-0.9	-1.8	1.1	-0.3	0.2
Conditioned locomotion	0.9	1.1	3.3	1.8	-0.5	-0.4	0.7	-1.1	1.1
Patch foraging indifference point 0 sec	1.3	2.1	3.9	-1.3	1.3	2.0	-1.6	1.4	0.6
Patch foraging indifference point AUC	0.4	0.4	1.1	-0.6	0.1	1.1	-0.2	-0.4	-0.9
Delay disc. indifference point, 0s delay	0.1	0.1	0.5	-0.1	-0.3	0.3	-0.2	0.7	-0.1
Delay disc. indifference point, 16s delay	0.9	0.9	1.3	1.1	-1.2	-0.7	1.0	-0.8	-0.9
Delay disc. indifference point, 2s delay	0.3	0.4	0.8	0.6	-0.9	-0.4	0.6	-0.2	-0.8
Delay disc. indifference point, 24s delay	1.1	1.1	1.7	1.3	-1.1	-0.9	1.2	-0.9	-0.6
Delay disc. indifference point, 4s delay	2.0	2.1	3.2	1.2	-1.8	-1.1	1.5	-1.4	-1.6
Delay disc. indifference point, 8s delay	1.6	1.6	3.1	1.3	-1.8	-0.8	1.3	-0.9	-1.4
Indifference point function ln k	0.1	0.2	0.5	-0.1	-0.2	-0.7	0.5	0.5	-0.4
Indifference point function log k	0.1	0.2	0.5	-0.1	-0.2	-0.7	0.5	0.5	-0.4
Patch foraging total patch changes 0 sec	1.5	2.5	3.7	-1.4	1.5	1.9	-1.7	1.7	0.9
Patch foraging total patch changes 12 sec	0.5	0.6	1.3	-0.7	0.8	1.1	-0.9	0.3	0.4
Patch foraging total patch changes 18 sec	2.5	3.3	6.3	-1.6	1.8	2.5	-2.0	1.5	1.0
Patch foraging total patch changes 24 sec	2.3	2.8	3.5	-1.8	1.7	1.9	-1.8	1.7	1.1
Patch foraging total patch changes 6 sec	0.2	0.3	1.2	-0.1	0.3	1.1	-0.5	0.2	0.2
Patch foraging time to switch 0 sec	0.4	0.6	1.2	1.1	-0.5	-1.1	0.8	-0.3	0.4
Patch foraging water rate 0 sec	0.2	0.4	0.8	-0.9	0.6	0.7	-0.8	0.4	0.2
Patch foraging water rate 12 sec	0.3	0.4	0.5	-0.7	0.7	0.4	-0.7	0.6	0.7
Patch foraging water rate 18 sec	0.6	0.8	2.9	-1.3	0.2	0.0	-0.6	1.7	-0.3
Patch foraging water rate 24 sec	0.9	1.2	2.2	-1.3	1.0	1.0	-1.1	1.5	0.5
Patch foraging water rate 6 sec	0.4	0.6	1.5	-1.2	0.6	1.0	-0.6	0.4	-0.6
Seeking ratio, delayed vs. immediate footshock	1.1	1.2	2.7	1.4	-1.7	-0.8	0.9	-0.9	-0.8
Distance traveled before self-admin	0.2	0.3	0.8	-0.5	0.1	-0.2	-0.4	0.9	0.5
Distance traveled after self-admin	0.7	0.8	1.4	0.9	-0.5	-1.1	1.2	-1.0	-0.2
Extensor digitorum longus weight	0.2	0.7	1.5	0.8	-0.8	-1.2	0.6	-0.9	0.0
Bone: elastic displacement	0.1	0.1	0.5	-0.7	0.3	-0.2	-0.2	0.1	-0.3
Bone: elastic work	0.9	1.2	3.8	-2.0	0.8	0.6	-0.8	1.0	-0.8
Bone: endosteal estimation	0.1	0.3	0.5	-0.3	0.5	0.7	-0.6	0.6	0.5
Bone: endosteal perimeter	0.8	1.7	2.2	1.3	-1.5	-1.4	1.5	-1.1	-1.0
Epididymis fat weight	0.7	1.6	4.0	-1.6	0.7	1.2	-1.2	2.0	0.0
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.0	-0.2	0.3	-0.2	0.1	-0.1
Delta time in open arm before/after self-admin	0.2	0.2	0.5	-0.2	0.5	0.3	0.3	-0.7	-0.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.7	0.1	-0.0	-0.8	0.3	0.1	0.3
Delay discount exponential model param	2.2	2.3	3.8	-1.5	2.0	1.1	-1.6	1.2	1.6
Extinction: sum of active levers before priming	0.6	0.5	1.3	-0.6	0.2	1.1	-0.8	1.0	0.0
Active lever presses in extinction session 6	1.0	0.9	1.8	-0.8	0.7	1.3	-1.1	1.1	0.6
Bone: final force	0.8	1.3	2.8	-1.7	1.1	0.9	-1.2	1.2	0.3
Bone: final moment	1.0	1.7	3.4	-1.8	1.3	0.9	-1.4	1.4	0.4
Food consumed during 24 hour testing period	1.4	1.7	2.9	-1.1	1.3	0.9	-1.3	1.7	1.4
Glucose	0.2	0.3	0.9	-0.2	0.5	1.0	-0.5	0.2	0.4
Heart weight	1.8	2.6	4.1	-1.6	1.8	0.9	-1.9	1.1	2.0
Delay discount hyperbolic model param	2.2	2.3	3.9	-1.6	2.0	1.1	-1.6	1.2	1.6
Intermittent access intake day 1-15 change	0.6	0.6	2.0	0.5	-0.6	-1.4	0.7	-0.8	0.2
Intermittent access intake escalation	0.5	0.5	1.4	0.4	-0.5	-1.2	0.5	-0.8	0.2
Intermittent access intake escalation 2	0.4	0.4	1.3	0.2	0.2	-1.0	0.1	-0.5	1.1
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	0.3	-0.1	-0.1	0.1	0.3	0.4
Intermitt. access day 15 inactive lever presses	0.8	0.9	1.8	0.3	-1.0	-1.4	0.9	-0.5	-1.1
Intermitt. access escalation Index	0.3	0.3	0.9	-0.5	0.1	0.9	-0.6	0.2	-0.3
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	-0.0	0.2	-0.1	-0.1	0.1
Intermittent access day 15 total infusions	0.2	0.2	0.5	0.5	-0.3	-0.6	0.2	-0.7	0.4
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	0.5	-0.1	-0.3	0.1	-0.2	0.6
Intermittent access total infusions	0.1	0.1	0.2	0.5	-0.4	-0.3	0.2	-0.4	0.1
Intermittent access day 1 locomotion	0.5	0.6	1.7	1.3	-0.2	-0.4	0.6	-0.7	0.8
Intermittent access day 15 total locomotion	0.7	0.7	2.2	1.5	-0.6	-0.5	0.7	-0.8	0.6
Intermittent access total locomotion	0.9	1.0	2.6	1.6	-1.0	-0.6	1.0	-1.1	0.1
Intermittent access standard deviation	0.4	0.4	1.1	-0.0	0.6	-1.0	0.2	-0.4	1.1
Left kidney weight	0.6	1.7	3.7	-1.4	1.2	1.9	-1.2	1.3	0.4
Right kidney weight	0.2	0.6	1.6	-0.7	0.5	1.3	-0.8	0.7	0.2
Cocaine induced anxiety	0.7	0.8	1.5	1.0	-0.9	-1.2	0.9	-0.7	-0.0
Post-drug Anxiety	0.5	0.5	1.0	1.0	-0.7	-0.9	0.7	-0.6	0.3
Baseline Anxiety	0.1	0.1	0.1	0.2	-0.4	-0.1	0.2	-0.2	-0.4
Tail length	4.9	14.8	20.9	-3.8	4.6	4.1	-4.1	2.9	3.3
Length with tail	7.6	27.8	35.5	-5.5	6.0	5.3	-5.8	4.7	4.1
Length without tail	6.5	14.1	19.1	-4.3	3.9	3.6	-4.4	3.8	2.1
Times rat made contact with spout	0.4	0.4	1.6	-0.1	0.6	0.3	-0.6	0.4	1.3
Lifetime Intake	0.1	0.1	0.4	0.6	-0.3	-0.3	0.3	-0.3	0.3
Liver weight, left	0.2	0.3	0.9	0.3	0.2	1.0	-0.4	0.6	0.5
Liver weight, right	1.3	2.1	3.4	-1.5	1.3	1.8	-1.5	1.7	0.5
Locomotor activity	4.9	7.7	11.3	-2.6	3.4	2.5	-2.8	2.8	2.6
Locomotor testing distance	4.7	7.8	11.2	-2.3	3.3	2.4	-2.6	3.1	2.9
Locomotor testing rearing	0.6	0.9	3.1	-0.0	0.9	0.4	-0.8	0.7	1.8
Locomotion in novel chamber	0.1	0.1	0.4	0.1	-0.4	-0.6	0.4	-0.2	-0.4
Locomotion in novel chamber post-restriction	0.6	0.8	1.5	-0.8	0.9	1.2	-1.0	0.6	0.4
Fecal boli incidents, locomotor time 1	0.6	0.7	1.6	-1.3	0.6	0.8	-1.1	0.6	-0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.3	0.4	0.5	-0.2	0.5	-0.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.5	0.5	-0.4	-0.0	0.4	-0.7	-0.4
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.0	-0.0	0.0
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.2	0.0	0.1	-0.1	0.2	0.0
Rest time, locomotor task time 1	0.2	0.2	0.7	0.6	-0.8	-0.3	0.3	-0.0	-0.1
Distance moved, locomotor task time 1	1.2	1.3	2.4	-1.5	1.5	0.8	-1.0	1.1	0.4
Vertical activity count, locomotor time 1	0.4	0.5	1.2	-0.9	1.1	0.6	-0.5	0.3	0.2
Time >=10cm from walls, locomotor time 2	1.6	1.7	2.7	-1.6	1.3	1.5	-1.5	1.2	0.4
Bouts of movement, locomotor time 2	0.3	0.3	0.9	-1.0	0.0	0.2	-0.6	0.6	-0.5
Total resting periods, locomotor time 2	0.3	0.3	0.6	-0.8	-0.3	0.1	-0.4	0.5	-0.8
Rest time, locomotor task time 2	0.1	0.1	0.6	-0.3	-0.2	0.3	-0.1	0.2	-0.8
Distance moved, locomotor task time 2	0.6	0.7	1.3	-0.6	0.8	0.4	-0.8	0.9	1.2
Vertical activity count, locomotor time 2	0.1	0.1	0.5	0.3	0.2	-0.2	0.1	0.1	0.7
Light reinforcement 1	0.6	1.1	2.7	-1.0	0.9	1.0	-0.8	1.6	0.5
Light reinforcement 2	0.2	0.3	0.7	-0.1	-0.4	0.4	0.2	0.8	-0.9
Bone: marrow area	0.1	0.3	0.6	-0.3	0.6	0.7	-0.6	0.6	0.5
Bone: maximum diameter	0.4	0.7	1.4	0.5	-0.8	-1.2	0.9	-0.7	-0.7
Bone: maximum force	0.8	1.3	2.4	-1.5	1.1	1.1	-1.2	1.3	0.2
Bone: maximum moment	0.9	1.5	2.5	-1.6	1.2	1.0	-1.3	1.5	0.4
Mean time between licks in bursts	0.9	1.3	2.3	1.3	-1.1	-1.5	1.2	-1.1	-0.2
Mean num. licks in bursts	0.4	0.5	1.0	-0.4	0.7	1.0	-0.8	0.4	0.6
Cd content in liver	2.4	2.6	5.8	-0.9	1.8	1.1	-1.8	1.3	2.4
Co content in liver	0.1	0.1	0.3	-0.6	0.3	-0.0	-0.3	0.1	-0.2
Cu content in liver	4.4	5.3	9.6	-2.1	2.3	2.3	-2.2	3.1	1.5
Fe content in liver	1.3	1.6	2.7	-1.1	1.6	1.1	-1.6	0.2	1.4
K content in liver	1.0	1.0	2.5	-1.6	0.7	1.2	-0.5	0.2	-1.1
Mg content in liver	0.7	0.8	2.9	-1.0	-0.0	0.4	0.2	-0.6	-1.7
Mn content in liver	1.0	1.2	2.4	-1.5	0.9	1.5	-0.7	0.6	-0.9
Na content in liver	0.3	0.3	0.6	-0.5	0.6	0.8	-0.5	-0.4	0.1
Rb content in liver	1.3	1.6	4.6	-0.3	1.4	0.5	-1.4	0.9	2.1
Se content in liver	0.3	0.3	1.0	-0.6	-0.1	0.1	0.1	-0.8	-1.0
Sr content in liver	0.2	0.2	0.6	-0.6	-0.0	0.3	0.1	0.2	-0.8
Zn content in liver	4.8	5.3	7.3	-2.6	2.3	2.7	-2.3	2.7	0.7
Bone: minimum diameter	0.2	0.3	0.5	0.3	-0.7	-0.7	0.6	-0.3	-0.6
Time in familiar zone, hab. session 1	1.1	1.1	1.8	1.3	-0.9	-1.4	0.7	-1.2	0.3
Time in novel zone, hab. session 1	0.3	0.3	0.5	-0.3	0.5	0.4	-0.3	0.7	0.7
Total zone transitions, hab. session 1	0.6	0.8	1.8	-1.0	0.8	1.3	-0.7	1.0	0.1
Total locomotion distance, hab. session 1	0.2	0.3	0.6	-0.6	0.5	0.8	-0.5	0.5	0.0
Locomotion velocity, hab. session 1	0.4	0.5	1.1	-0.9	0.5	1.1	-0.5	0.6	-0.4
Time in familiar zone, hab. session 2	0.5	0.6	1.4	0.2	-0.5	-0.9	0.6	-1.2	-0.7
Time in novel zone, hab. session 2	0.4	0.4	1.5	0.7	0.1	0.2	-0.1	0.8	1.2
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.4	0.2	0.4	-0.1	0.3	-0.2
Total locomotion distance, hab. session 2	0.3	0.4	0.8	-0.9	0.5	0.9	-0.5	0.4	-0.4
Locomotion velocity, hab. session 2	0.3	0.3	0.7	-0.8	0.3	0.8	-0.3	0.1	-0.7
Novel to familiar place preference ratio	1.1	1.2	3.6	-0.4	1.0	1.9	-1.0	0.8	0.7
Novelty place preference	1.1	1.2	3.7	-0.4	1.0	1.9	-1.0	0.9	0.6
Time in novel zone, NPP test	1.4	1.4	3.6	-0.4	1.1	1.9	-1.2	1.0	1.1
Total zone transitions, NPP test	2.0	2.9	5.0	-2.0	1.7	2.2	-1.5	1.6	0.3
Total locomotion distance, NPP test	0.8	1.2	2.1	-1.5	1.0	1.3	-1.0	1.0	0.1
Locomotion velocity, NPP test	1.0	1.4	2.8	-1.7	1.1	1.5	-1.1	0.9	-0.3
Intraocular pressure	1.3	1.8	4.3	-0.4	1.4	1.2	-1.5	1.1	2.1
Delta distance traveled before/after self-admin	0.8	0.8	1.9	1.0	-0.4	-0.7	1.1	-1.4	-0.6
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	0.4	0.5	0.0	0.3	-0.6	0.3
Parametrial fat weight	0.7	1.3	2.0	-0.9	1.2	1.3	-1.0	1.4	1.0
Pavlov. Cond. lever latency	4.5	5.6	9.7	-1.4	2.6	2.0	-2.6	2.2	3.1
Pavlov. Cond. magazine entry latency	5.7	7.3	9.0	2.2	-2.9	-2.7	3.0	-2.6	-2.7
Pavlov. Cond. change in total contacts	1.5	1.6	3.1	0.6	-1.2	-0.9	1.1	-1.8	-1.7
Pavlov. Cond. index score	5.7	7.3	8.8	1.9	-2.9	-2.6	2.9	-2.8	-3.0
Pavlov. Cond. latency score	5.6	7.1	9.8	1.8	-2.8	-2.4	2.9	-2.8	-3.1
Pavlov. Cond. lever contacts	2.7	3.1	6.0	1.0	-1.9	-1.4	1.9	-1.7	-2.4
Pavlov. Cond. magazine entry number	6.3	7.9	9.4	-2.5	3.0	2.8	-3.1	2.9	2.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.7	-0.4	0.8	0.5	-0.7	0.2	0.8
Pavlov. Cond. lever-magazine prob. diff.	5.2	6.5	7.4	1.8	-2.7	-2.6	2.7	-2.7	-2.7
Pavlov. Cond. response bias	5.8	7.1	8.6	2.2	-2.9	-2.8	2.9	-2.5	-2.6
Pavlov. Cond. lever latency	0.5	0.7	1.6	1.3	-0.8	-0.8	0.8	-0.6	0.1
Pavlov. Cond. magazine entry latency	0.2	0.3	1.1	-0.4	-0.3	-0.3	0.4	-0.4	-1.0
Pavlov. Cond. change in total contacts	2.0	2.7	4.8	-2.2	1.9	1.5	-1.9	1.1	0.9
Pavlov. Cond. index score	0.3	0.3	1.2	-1.1	0.3	0.3	-0.3	0.2	-0.7
Pavlov. Cond. latency score	0.2	0.3	1.1	-1.0	0.2	0.2	-0.2	0.2	-0.8
Pavlov. Cond. lever contacts	0.9	1.3	2.2	-1.5	1.2	1.3	-1.1	1.0	0.3
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	0.1	0.5	0.5	-0.6	0.7	1.0
Pavlov. Cond. intertrial magazine entries	0.3	0.3	1.1	1.0	-0.5	-0.5	0.5	-0.4	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.1	-1.0	0.3	0.2	-0.2	0.2	-0.6
Pavlov. Cond. response bias	0.2	0.2	0.8	-0.9	0.3	0.3	-0.3	0.1	-0.5
Time in closed arm before self-admin	1.1	1.2	2.0	-0.9	1.4	0.7	-1.0	1.1	1.4
Time in closed arm after self-admin	0.1	0.1	0.5	-0.0	0.2	0.1	-0.3	0.4	0.7
Time in open arm before self-admin	0.7	0.8	1.6	1.2	-1.2	-1.0	0.7	-0.4	-0.2
Time in open arm after self-admin	0.6	0.7	1.4	0.8	-0.4	0.1	1.0	-1.2	-1.0
Bone: periosteal estimation	0.0	0.1	0.3	-0.6	0.2	0.2	-0.3	0.2	-0.2
Bone: periosteal perimeter	0.8	1.4	1.8	0.8	-1.3	-1.3	1.3	-1.0	-1.3
Bone: post-yield work	0.1	0.1	0.4	-0.1	0.2	0.2	-0.2	0.6	0.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.4	0.1	0.5	-0.1	0.1	0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.4	-0.0	0.4	-0.1	0.1	0.4
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.8	1.1	-0.6	-1.3	1.1	-0.7	0.2
Progressive ratio test 2 active lever presses	0.8	0.8	1.4	1.2	-0.9	-0.9	0.9	-1.1	0.1
Progressive ratio test 2 breakpoint	0.5	0.6	1.0	1.0	-0.8	-0.8	0.7	-0.9	0.1
Progressive ratio test 2 inactive lever presses	2.1	2.5	4.8	1.7	-1.4	-2.2	1.7	-1.6	-0.2
Incentive Sensitization - Responses	1.4	1.4	2.5	1.3	-1.3	-1.6	1.2	-1.2	-0.3
Incentive Sensitization - Breakpoint	1.4	1.4	2.4	1.2	-1.3	-1.6	1.2	-1.1	-0.3
Sum of active levers in priming session hrs 5-6	0.3	0.2	0.4	-0.2	0.7	0.6	-0.4	0.2	0.7
Progressive ratio	3.5	4.0	5.2	-1.6	2.1	2.3	-2.1	2.2	1.7
Food seeking constrained by brief footshock	0.5	0.6	0.9	0.9	-0.9	-0.8	0.6	-1.0	-0.0
Seeking ratio, punishment vs. effort	4.6	5.6	7.9	2.2	-2.5	-2.8	2.4	-2.6	-1.5
Retroperitoneal fat weight	0.9	2.9	4.5	-2.0	1.3	2.0	-1.8	2.1	0.3
Reaction time number correct	0.4	0.6	1.5	1.2	-0.5	-0.9	0.8	0.0	0.8
Reaction time mean minus median	0.0	0.0	0.1	0.2	0.1	0.0	0.2	-0.2	0.3
Reaction time mean minus median AUC	0.2	0.2	0.9	0.1	0.5	0.5	-0.3	0.2	0.9
Reaction time num false alarms	0.3	0.4	1.3	1.1	-0.4	-0.4	0.6	-0.7	0.3
Reaction time num false alarms AUC	0.2	0.2	0.9	0.9	-0.1	-0.0	0.3	-0.2	0.6
Reaction time trials correct on left	0.4	0.6	1.5	1.2	-0.5	-0.9	0.8	0.0	0.8
Reaction time trials on left	0.5	0.7	1.7	1.3	-0.5	-1.0	0.8	0.0	0.9
Reaction time mean	0.0	0.0	0.2	0.2	0.2	-0.1	0.1	0.0	0.4
Reaction time mean AUC	0.1	0.1	0.2	0.4	0.1	-0.0	0.1	0.1	0.5
Median of all reaction times	0.0	0.1	0.2	0.2	0.2	-0.1	0.0	0.1	0.5
Reaction time omissions	0.8	1.1	3.1	1.8	-0.6	-1.0	0.7	-0.7	1.1
Reaction time false alarm rate	0.0	0.1	0.2	0.4	-0.1	0.2	0.0	-0.4	-0.1
Reaction time premature initiation rate	1.2	1.6	3.0	-1.2	1.7	1.2	-1.1	1.5	0.8
Reaction time premature initiations	0.6	0.9	1.8	-0.6	1.3	0.5	-0.5	1.3	1.0
Std. dev. reaction times	0.1	0.2	0.6	0.3	0.5	0.4	-0.1	-0.1	0.8
Reaction time trials completed	0.5	0.7	1.7	1.3	-0.5	-1.0	0.8	0.0	0.9
Reaction time trials AUC	0.6	0.8	2.0	1.4	-0.6	-1.0	0.9	-0.1	0.9
Run reversals in cocaine runway, females	1.4	1.3	2.0	0.8	-1.4	-1.3	1.1	-0.8	-1.3
Run reversals in cocaine runway, males	0.3	0.3	0.5	0.3	0.7	-0.6	0.2	-0.6	0.6
Latency to leave start box in cocaine runway	0.1	0.1	0.4	-0.2	0.6	-0.0	-0.1	-0.4	0.3
Latency to leave start box in cocaine runway, F	0.5	0.5	1.5	-0.8	1.2	-0.0	-0.5	0.1	0.9
Latency to leave start box in cocaine runway, M	0.4	0.4	1.2	0.4	-0.6	0.0	0.5	-0.5	-1.1
Std. dev. time between licks in bursts	2.5	2.9	5.6	1.6	-1.9	-2.4	1.9	-1.1	-0.9
Total sessions with >9 infusions	0.3	0.4	1.6	0.2	0.1	-0.5	-0.2	0.6	1.2
Short access day 1 total inactive lever presses	1.9	2.1	3.2	1.6	-1.7	-1.8	1.5	-1.1	-0.7
Short access day 10 total inactive lever presses	0.5	0.6	1.9	0.5	-0.3	-1.4	0.8	-0.7	0.1
Short access day 1 total infusions	0.5	0.5	0.8	0.9	-0.9	-0.9	0.7	-0.4	-0.1
Short access day 10 total infusions	0.1	0.1	0.2	-0.1	0.1	0.4	-0.5	0.4	0.4
Short access total infusions	0.2	0.2	0.7	0.9	-0.5	-0.3	0.4	-0.3	0.3
Short access day 1 locomotion	0.3	0.3	1.2	0.6	0.0	0.1	-0.2	0.5	1.1
Short access day 10 total locomotion	0.2	0.2	0.7	0.1	0.3	0.8	-0.3	0.2	0.4
Short access total locomotion	0.5	0.5	1.8	1.0	0.2	0.4	-0.0	-0.2	1.3
One hour access (0.3 mA shock)	0.2	0.3	0.8	0.9	-0.1	0.1	0.2	-0.1	0.9
Compulsive drug intake	0.1	0.1	0.5	0.0	-0.2	0.7	-0.2	0.5	-0.2
One hour access (shock baseline)	0.3	0.3	0.6	0.7	0.0	-0.5	0.3	-0.6	0.8
Social response proportion	0.3	0.3	1.0	-0.1	0.4	0.5	-0.3	1.0	0.5
Social responses	0.4	0.6	1.4	-0.7	0.5	1.0	-0.5	1.2	0.1
Social time	1.3	1.7	4.7	1.3	-1.1	-2.2	1.6	-0.0	-0.1
Soleus weight	3.0	8.9	11.6	-3.3	3.4	2.9	-3.4	2.5	2.3
Bone: stiffness	0.1	0.2	0.4	-0.5	0.5	0.6	-0.6	0.4	0.3
Tibialis anterior weight	0.0	0.1	0.1	-0.4	0.2	-0.1	-0.4	0.1	0.4
Time to tail flick, vehicle, before self-admin	2.2	2.2	3.3	-1.4	1.3	1.5	-1.8	1.4	1.4
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	-0.6	0.6	-0.0	-0.1	0.2	0.1
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.6	-0.1	0.5	-0.1	0.7	0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.0	-0.4	-0.5	0.3	-0.1	-0.5
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.5	0.4	-0.8	-1.2	1.2	-0.8	-1.2
Delta time to tail flick, test, before/after SA	0.4	0.3	1.2	-0.6	-0.4	-0.2	0.1	-0.4	-1.1
Tibia length	6.5	18.4	27.4	-5.2	4.3	4.4	-4.2	5.0	1.6
Ambulatory time before self-admin	0.2	0.2	0.8	-0.4	-0.2	-0.3	-0.2	0.9	0.1
Ambulatory time after self-admin	0.2	0.2	0.4	0.6	-0.2	-0.5	0.6	-0.6	-0.1
Bone: tissue strength	3.1	3.0	5.6	-2.4	1.8	1.4	-1.9	1.7	0.6
Total heroin consumption	0.8	1.0	1.5	-1.0	1.2	0.6	-0.8	1.2	0.9
Bone: trabecular number	0.6	0.9	1.6	0.6	-0.9	-0.3	0.9	-1.3	-1.3
Bone: trabecular spacing	1.2	1.6	3.0	-1.2	1.3	0.8	-1.3	1.7	1.1
Bone: trabecular thickness	0.5	0.5	1.8	-0.8	0.0	0.9	-0.1	0.1	-1.3
Bone: trabecular tissue density	0.1	0.2	0.3	-0.1	0.5	0.6	-0.3	0.4	0.4
Water consumed over 24 hours	0.1	0.1	0.4	-0.1	-0.1	-0.6	0.1	0.4	0.2
Number of responses in last shaping day	0.3	0.3	0.7	0.2	-0.8	-0.8	0.3	-0.7	-0.4