Hub : Genes

Dcaf5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL isoform ratio XM_017594145.3 0.04 0.03 9.3e-03 0 0.01 0.01 0 8.9e-02 3.2e-02 3.1e-02 1.4e-01
2 PL isoform ratio XM_006240279.5 0.08 0.06 1.8e-03 0.01 0.01 0.01 0 6.4e-02 1.4e-02 7.1e-03 1.0e-01
3 LHb gene expression Dcaf5 0.23 0.12 2.1e-03 0.18 0.15 0.09 0.16 3.9e-05 2.0e-04 4.1e-03 1.1e-04
4 Liver gene expression Dcaf5 0.06 0.03 1.1e-06 0.04 0.05 0.04 0.04 2.7e-05 4.4e-06 1.8e-05 1.9e-05
5 BLA gene expression Dcaf5 0.34 0.12 7.1e-08 0.11 0.12 0.11 0.12 3.0e-06 9.3e-07 1.8e-06 1.1e-06
6 Brain alternative TSS XM_008764782.4 0.04 0.02 6.2e-03 0.05 0.02 0.03 0.04 1.4e-05 6.0e-03 7.0e-04 5.6e-05
7 PL gene expression Dcaf5 0.21 0.07 3.0e-15 0.07 0.13 0.13 0.12 7.1e-08 2.4e-14 7.3e-14 2.1e-13
8 pVTA gene expression Dcaf5 0.22 0.09 2.8e-09 0.06 0.12 0.11 0.1 2.4e-05 1.7e-09 6.0e-09 1.6e-08
9 NAcc gene expression Dcaf5 0.29 0.11 1.4e-10 0.02 0.08 0.08 0.08 1.4e-04 6.7e-12 3.8e-12 1.5e-11
10 pVTA intron excision ratio chr6_104966958_104992979 0.08 0.04 1.2e-04 0.06 0.05 0.03 0.05 1.5e-05 3.7e-05 2.0e-03 8.7e-05
11 IC gene expression Dcaf5 0.24 0.12 3.0e-05 0.02 0.06 0.1 0.1 3.7e-02 1.4e-03 7.7e-05 7.4e-05
12 Liver alternative TSS XM_006240279.5 0.04 0.02 2.8e-03 0.02 0.03 0.03 0.03 5.4e-03 6.5e-04 6.6e-04 6.9e-04
13 Brain gene expression Dcaf5 0.29 0.1 1.3e-12 0.08 0.14 0.13 0.14 1.2e-07 2.1e-13 3.6e-12 6.3e-13
14 Adipose gene expression Dcaf5 0.06 0.03 3.2e-05 0.02 0.03 0.03 0.02 2.3e-03 3.5e-04 4.0e-04 1.3e-03
15 Adipose alternative TSS NM_001100718.1 0.03 0.02 6.7e-03 0.01 0.01 0.01 0.01 2.1e-02 2.0e-02 1.1e-02 2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.20.41.70.5-0.70.9-1.30.2-0.5-0.00.0-0.3-1.2-0.20.5-0.1-0.90.3
Area under the delay curve0.10.11.00.1-0.50.2-0.10.2-0.20.10.1-0.2-1.00.20.40.4-0.00.4
BMI with tail2.48.213.2-3.13.2-2.9-2.2-3.32.6-3.3-3.3-3.61.9-3.5-2.7-3.50.1-1.1
BMI without tail0.30.96.40.00.40.3-2.5-0.7-0.5-0.9-0.8-1.1-0.9-1.0-0.3-1.0-1.10.2
Body weight0.41.68.81.9-0.91.1-3.00.5-1.8-0.1-0.20.5-1.5-0.10.5-0.3-0.71.7
Weight adjusted by age0.50.74.40.30.00.4-2.1-0.6-0.8-0.8-0.6-0.8-0.5-0.50.1-1.0-1.50.4
Bone surface0.61.04.30.4-0.81.4-1.7-0.0-1.0-0.10.1-0.8-1.7-0.20.6-0.3-2.1-0.6
Bone volume1.01.75.61.2-1.72.0-1.10.9-1.10.91.00.3-2.40.51.60.6-2.00.4
Breakpoint value in progressive ratio session1.01.25.8-0.30.40.4-2.4-0.90.4-1.2-1.2-0.9-0.1-1.5-0.8-1.6-0.90.5
Number of licking bursts1.11.73.7-1.91.5-1.71.3-1.21.7-1.0-0.9-1.51.2-0.9-1.0-0.80.3-1.7
Context. condit. distance diff. score0.60.71.61.0-1.10.90.21.2-0.50.70.71.30.20.70.31.21.00.3
Locomotion velocity, session 10.20.20.8-0.10.4-0.2-0.4-0.8-0.0-0.5-0.4-0.7-0.1-0.5-0.3-0.9-0.8-0.2
Locomotion distance, session 11.72.23.9-1.72.0-1.90.6-1.51.4-1.3-1.3-1.51.6-1.2-1.7-1.20.8-1.5
Locomotion velocity, session 20.30.31.2-0.0-0.2-0.10.90.60.40.60.40.90.20.40.20.71.10.6
Locomotion distance, session 21.52.04.9-1.91.8-2.21.1-1.32.2-1.1-1.2-1.31.2-1.3-1.1-1.10.8-0.7
Locomotion velocity, session 36.37.211.72.5-3.02.03.13.2-1.43.33.23.4-1.53.12.83.40.71.4
Locomotion distance, session 31.31.42.21.2-1.31.21.41.3-1.11.41.50.9-0.71.51.11.2-0.7-1.0
Stereotopy head waving bouts, day 31.11.35.01.3-1.41.4-0.50.6-1.00.70.80.5-2.20.71.60.4-1.41.0
Stereotopy head waving duration, day 31.41.63.31.4-1.71.50.21.3-1.01.31.31.2-1.81.21.61.2-0.71.0
Locomotion velocity, session 70.50.61.80.0-0.20.41.30.60.01.01.10.70.50.90.20.9-0.1-1.3
Locomotion distance, session 70.70.81.8-1.21.3-1.30.5-0.81.1-0.6-0.6-0.71.3-0.6-1.0-0.50.7-0.8
Stereotopy head waving bouts, day 72.12.44.72.2-2.01.8-0.31.5-1.91.31.31.3-2.11.31.81.2-1.01.1
Stereotopy head waving duration, day 73.03.67.32.7-2.52.2-0.32.2-2.21.81.72.0-2.11.62.01.7-0.41.5
Locomotion velocity, session 80.40.51.5-0.60.5-0.6-0.1-0.51.2-0.5-0.60.10.9-0.6-0.5-0.41.01.0
Locomotion distance, session 80.30.52.0-0.50.3-0.81.10.21.3-0.1-0.20.20.7-0.3-0.40.21.4-0.3
Degree of sensitization distance1.11.22.1-1.31.4-1.4-0.6-1.11.3-1.1-1.2-0.81.1-1.1-1.2-0.81.10.3
Degree of sensitization stereotypy2.12.24.32.1-1.91.7-0.21.7-1.91.41.31.4-1.71.31.61.4-0.40.9
Conditioned locomotion2.12.45.41.4-1.40.82.31.5-1.41.91.91.3-1.22.11.82.0-0.3-0.4
Cocaine response after cond. corrected0.80.93.80.3-0.70.62.00.9-0.41.01.10.80.51.40.41.20.2-1.2
Cocaine response after cond. not corrected0.50.62.70.1-0.60.51.60.7-0.30.90.90.80.51.20.31.00.3-0.7
Cocaine response before conditioning0.30.41.3-0.60.6-0.3-1.2-0.80.2-0.7-0.7-0.8-0.1-0.7-0.5-0.7-0.30.4
Saline control response0.10.21.0-1.00.3-0.60.3-0.30.7-0.1-0.1-0.5-0.3-0.20.30.20.10.4
Bone: connectivity density0.20.31.1-0.30.10.1-1.0-0.3-0.0-0.7-0.8-1.0-0.1-0.8-0.5-0.6-0.1-0.4
Bone: cortical apparent density0.20.31.00.3-0.30.20.50.6-0.10.70.60.6-0.50.50.61.00.30.0
Bone: cortical area1.62.54.52.0-2.11.81.02.1-1.41.81.71.6-1.51.61.61.6-0.3-0.1
Bone: cortical porosity0.30.30.90.10.4-0.4-1.0-0.3-0.1-0.7-0.8-0.20.3-0.4-0.6-0.60.60.7
Bone: cortical porosity0.10.10.70.30.1-0.0-0.8-0.1-0.5-0.4-0.5-0.20.0-0.1-0.3-0.40.30.5
Bone: cortical thickness0.50.94.50.3-0.5-0.32.11.20.60.80.60.90.30.60.31.11.6-0.5
Bone: cortical thickness1.31.57.9-1.01.1-1.92.8-0.11.5-0.1-0.3-0.01.3-0.1-0.70.32.0-0.7
Bone: cortical tissue density0.10.20.80.2-0.20.10.40.5-0.00.60.60.5-0.40.40.50.90.2-0.1
Condit. Reinf. active minus inactive responses0.30.31.50.8-0.50.3-0.60.6-0.50.1-0.20.70.00.1-0.00.21.01.2
Condit. Reinf. active-inactive response ratio0.70.81.91.4-1.20.9-0.21.2-0.80.70.51.2-0.60.60.60.80.71.2
Condit. Reinf. active responses0.40.52.50.10.4-0.6-0.60.00.2-0.6-0.80.11.0-0.5-0.9-0.41.60.8
Condit. Reinf. inactive responses3.44.26.6-2.22.6-2.3-1.0-2.01.7-2.3-2.4-1.92.4-2.1-2.5-2.01.4-0.5
Incentive salience index mean0.20.31.50.6-0.40.3-0.50.6-0.4-0.0-0.30.60.60.1-0.40.11.20.9
Condit. Reinf. lever presses0.20.30.8-0.20.3-0.1-0.8-0.10.1-0.5-0.6-0.10.9-0.4-0.8-0.50.60.2
Condit. Reinf. active minus inactive responses2.43.27.0-2.62.1-2.1-1.1-1.92.3-1.9-1.9-1.81.1-2.1-1.6-1.41.00.3
Condit. Reinf. active-inactive response ratio0.80.92.7-1.60.9-0.9-0.8-0.91.5-1.0-1.0-1.00.2-1.3-0.7-0.70.50.3
Condit. Reinf. active responses0.50.81.6-1.30.7-0.7-1.2-0.91.1-1.0-1.0-0.70.2-1.1-0.6-0.60.50.9
Condit. Reinf. inactive responses0.10.10.50.4-0.40.2-0.10.3-0.30.20.20.4-0.20.40.30.40.20.7
Condit. Reinf. lever presses0.40.53.10.2-0.40.6-1.8-0.4-0.4-0.5-0.5-0.4-0.8-0.50.2-0.7-0.80.8
Condit. Reinf. lever reinforcers received0.81.12.3-1.40.9-0.9-1.5-1.11.1-1.2-1.3-0.90.4-1.3-0.9-0.80.71.0
Conditioned reinforcement - actives0.30.53.3-0.20.6-0.70.9-0.00.7-0.2-0.40.50.8-0.1-0.40.01.81.1
Conditioned reinforcement - inactives0.40.72.6-0.40.8-1.61.2-0.60.7-0.7-0.8-0.40.9-0.3-0.6-0.51.2-0.1
Conditioned locomotion0.70.94.5-0.20.2-1.31.90.31.00.1-0.10.90.30.40.00.42.11.0
Patch foraging indifference point 0 sec0.30.54.3-1.10.10.7-2.1-0.50.2-0.6-0.5-0.4-0.1-0.8-0.2-0.4-0.60.1
Patch foraging indifference point AUC0.81.12.41.2-1.60.90.31.2-0.91.11.11.5-0.51.20.91.20.30.6
Delay disc. indifference point, 0s delay2.22.44.0-1.41.8-1.6-1.5-1.90.9-1.9-2.0-1.81.3-1.6-1.8-1.40.90.3
Delay disc. indifference point, 16s delay2.02.23.61.1-1.71.41.01.7-1.01.81.91.2-1.91.61.81.9-0.50.3
Delay disc. indifference point, 2s delay0.60.61.4-0.30.5-0.6-1.2-0.80.6-1.0-1.2-0.20.2-1.0-0.8-0.80.71.0
Delay disc. indifference point, 24s delay0.10.20.40.1-0.60.30.40.5-0.20.40.50.2-0.50.40.30.60.0-0.4
Delay disc. indifference point, 4s delay0.20.21.5-0.30.1-0.00.1-0.3-0.1-0.4-0.3-1.2-0.1-0.4-0.2-0.3-0.4-0.6
Delay disc. indifference point, 8s delay0.20.21.2-0.1-0.30.5-0.9-0.20.1-0.2-0.2-0.3-1.1-0.30.2-0.0-0.20.7
Indifference point function ln k0.91.72.8-1.41.6-0.8-1.5-1.51.1-1.5-1.5-1.20.6-1.7-1.4-1.6-0.20.1
Indifference point function log k0.91.72.8-1.41.6-0.8-1.5-1.51.1-1.5-1.5-1.20.6-1.7-1.4-1.6-0.20.1
Patch foraging total patch changes 0 sec0.40.75.2-1.00.20.6-2.3-0.60.3-0.8-0.7-0.50.0-1.1-0.5-0.6-0.40.1
Patch foraging total patch changes 12 sec1.01.32.81.2-1.71.7-0.81.2-1.50.91.01.1-1.00.91.20.9-0.60.6
Patch foraging total patch changes 18 sec0.60.91.60.8-1.31.2-1.00.4-1.20.50.70.5-1.30.71.20.7-1.00.6
Patch foraging total patch changes 24 sec1.73.05.21.7-2.31.9-0.22.0-1.51.91.82.2-1.51.72.02.1-0.21.2
Patch foraging total patch changes 6 sec0.30.51.20.1-1.01.1-0.60.7-0.70.80.90.7-0.30.70.70.9-0.40.0
Patch foraging time to switch 0 sec1.22.45.11.4-1.51.02.31.5-1.12.02.11.1-1.12.01.91.6-1.0-0.3
Patch foraging water rate 0 sec1.12.27.3-1.21.3-0.7-2.7-1.50.7-1.9-2.0-1.11.0-2.0-1.8-1.60.60.3
Patch foraging water rate 12 sec0.51.02.0-0.41.0-0.8-1.3-0.70.9-1.0-1.20.10.7-1.2-1.0-0.51.41.3
Patch foraging water rate 18 sec0.91.34.0-0.50.9-0.7-1.2-0.41.1-1.1-1.40.01.0-1.4-1.2-0.72.02.0
Patch foraging water rate 24 sec2.13.05.7-1.22.1-1.4-2.4-1.51.2-2.1-2.3-1.31.2-2.0-2.0-1.51.81.2
Patch foraging water rate 6 sec0.50.85.90.10.20.1-2.4-0.4-0.2-0.9-0.9-0.2-0.6-0.9-0.3-0.8-0.31.2
Seeking ratio, delayed vs. immediate footshock0.60.71.90.3-0.50.31.11.0-0.51.21.30.6-0.21.30.61.40.1-0.6
Distance traveled before self-admin0.60.81.8-0.91.0-0.8-0.3-1.30.1-1.1-0.9-1.30.6-0.6-0.9-1.1-0.5-1.1
Distance traveled after self-admin0.10.10.70.4-0.20.3-0.2-0.0-0.5-0.1-0.10.0-0.80.10.2-0.3-0.30.3
Extensor digitorum longus weight0.10.42.00.3-0.60.6-0.30.3-0.20.40.50.2-1.40.30.90.4-0.90.0
Bone: elastic displacement0.50.51.9-0.50.8-1.31.4-0.11.0-0.1-0.20.10.7-0.2-0.30.21.1-0.6
Bone: elastic work0.60.84.8-0.20.5-1.21.20.21.0-0.1-0.30.61.0-0.0-0.40.42.20.8
Bone: endosteal estimation2.24.910.22.5-2.73.2-1.01.9-2.72.02.11.5-3.11.72.51.4-2.50.7
Bone: endosteal perimeter1.94.08.52.3-2.62.9-0.72.0-2.31.81.91.4-2.61.52.21.4-2.20.2
Epididymis fat weight0.20.82.3-0.50.8-1.5-0.2-0.91.2-0.9-1.0-0.60.8-0.9-0.5-1.00.71.2
Delta time in closed arm before/after self-admin0.20.20.60.0-0.3-0.00.80.40.50.40.30.60.60.30.30.50.60.5
Delta time in open arm before/after self-admin0.40.41.9-0.90.1-0.2-1.1-0.11.4-0.3-0.40.2-0.2-1.0-0.2-0.10.30.6
Diff in mean of infusions in LGA sessions1.31.53.7-1.11.0-0.9-1.9-1.30.7-1.6-1.6-1.40.4-1.9-1.1-1.5-0.20.0
Delay discount exponential model param0.20.21.1-0.20.6-0.3-0.0-0.30.1-0.3-0.30.11.0-0.3-0.5-0.50.0-0.3
Extinction: sum of active levers before priming1.61.83.91.4-1.92.0-0.41.6-0.61.31.11.8-1.50.71.41.0-0.41.5
Active lever presses in extinction session 60.90.92.90.5-1.21.7-1.30.4-0.20.20.20.4-1.5-0.21.0-0.2-1.21.5
Bone: final force0.10.21.30.3-0.1-0.1-0.10.40.5-0.0-0.20.50.3-0.1-0.10.01.21.0
Bone: final moment0.10.21.40.20.0-0.2-0.40.20.5-0.2-0.40.40.1-0.3-0.1-0.11.11.2
Food consumed during 24 hour testing period0.10.10.5-0.5-0.10.3-0.5-0.10.7-0.2-0.1-0.40.0-0.5-0.1-0.1-0.3-0.6
Glucose0.30.51.80.1-0.60.61.30.5-0.20.91.00.6-0.11.00.61.0-0.1-0.4
Heart weight0.81.22.51.3-1.21.3-1.00.9-1.40.80.80.8-1.61.01.31.0-0.70.9
Delay discount hyperbolic model param0.10.10.8-0.10.4-0.00.1-0.1-0.0-0.1-0.10.20.9-0.1-0.3-0.3-0.1-0.4
Intermittent access intake day 1-15 change0.51.02.7-1.61.2-1.10.7-0.71.6-0.8-0.90.01.2-0.7-1.0-0.41.3-0.1
Intermittent access intake escalation0.61.12.9-1.71.4-1.10.5-0.91.5-0.9-1.0-0.41.4-0.9-1.1-0.61.2-0.2
Intermittent access intake escalation 20.20.21.4-0.1-0.10.11.20.50.30.40.30.80.40.40.10.50.70.0
Intermitt. access day 1 inactive lever presses0.00.10.5-0.00.4-0.7-0.3-0.5-0.6-0.3-0.2-0.5-0.40.1-0.1-0.3-0.3-0.0
Intermitt. access day 15 inactive lever presses0.30.63.50.00.3-1.41.0-0.00.8-0.2-0.40.50.5-0.1-0.10.11.91.3
Intermitt. access escalation Index0.20.21.20.5-0.50.40.10.60.00.30.20.60.40.00.30.30.61.1
Intermittent access day 1 total infusions0.20.40.80.9-0.70.00.80.4-0.80.30.40.0-0.90.60.8-0.0-0.6-0.6
Intermittent access day 15 total infusions0.30.40.9-0.80.6-0.71.0-0.30.9-0.6-0.6-0.20.6-0.4-0.5-0.50.8-0.5
Intermittent access terminal intake (last 3 days)0.10.21.20.3-0.3-0.41.10.10.2-0.1-0.30.5-0.40.20.4-0.30.60.4
Intermittent access total infusions0.10.20.3-0.40.3-0.40.6-0.40.6-0.5-0.5-0.3-0.3-0.3-0.1-0.60.0-0.4
Intermittent access day 1 locomotion0.20.20.80.10.3-0.80.1-0.6-0.0-0.6-0.7-0.5-0.6-0.20.0-0.9-0.4-0.1
Intermittent access day 15 total locomotion0.30.51.5-0.90.8-1.20.3-0.80.9-0.9-1.0-0.20.0-0.5-0.6-0.80.5-0.3
Intermittent access total locomotion0.30.30.8-0.50.4-0.70.5-0.50.9-0.7-0.80.1-0.3-0.4-0.3-0.70.60.3
Intermittent access standard deviation0.10.31.10.5-0.70.11.00.4-0.30.40.40.7-0.30.80.80.50.20.4
Left kidney weight0.94.17.42.7-2.51.91.22.3-2.22.22.12.1-1.62.52.12.30.21.3
Right kidney weight1.88.313.13.4-3.43.11.93.1-3.13.33.32.9-2.53.63.03.1-1.00.2
Cocaine induced anxiety1.11.66.5-1.10.4-1.72.5-0.02.40.0-0.20.40.4-0.20.00.32.41.2
Post-drug Anxiety0.90.94.8-1.20.2-0.92.20.21.90.10.00.50.5-0.20.00.41.60.5
Baseline Anxiety0.40.52.20.2-0.41.2-0.80.3-1.10.10.30.00.10.20.10.0-1.5-1.2
Tail length3.312.924.14.9-4.24.4-0.53.7-4.43.53.53.9-3.73.73.53.5-1.02.3
Length with tail3.515.234.45.9-4.84.4-0.94.1-4.93.43.24.5-3.83.73.73.3-0.53.8
Length without tail1.03.29.43.1-2.42.0-1.31.7-2.91.11.11.6-1.51.51.51.0-0.81.6
Times rat made contact with spout0.40.42.1-0.10.10.5-1.4-0.4-0.1-0.3-0.2-0.7-0.9-0.50.0-0.6-1.5-0.5
Lifetime Intake0.10.10.6-0.0-0.1-0.20.80.00.3-0.1-0.20.1-0.60.10.3-0.10.30.2
Liver weight, left0.61.03.71.3-1.11.7-1.80.7-1.90.40.40.5-0.60.70.40.5-0.60.4
Liver weight, right0.10.20.80.2-0.30.50.20.1-0.90.30.5-0.30.00.6-0.00.0-0.7-0.9
Locomotor activity0.30.52.61.0-0.50.0-0.90.4-0.4-0.2-0.50.50.2-0.1-0.1-0.21.21.6
Locomotor testing distance0.30.53.30.6-0.4-0.50.00.30.4-0.2-0.50.40.0-0.30.10.01.61.8
Locomotor testing rearing0.20.31.40.7-0.70.3-0.60.5-0.20.0-0.10.3-0.9-0.20.60.00.31.2
Locomotion in novel chamber0.20.21.80.2-0.20.5-0.10.2-0.30.00.1-0.10.40.1-0.1-0.3-0.8-1.4
Locomotion in novel chamber post-restriction0.91.55.61.3-1.20.81.11.30.11.10.81.5-1.20.81.20.91.22.4
Fecal boli incidents, locomotor time 10.20.30.90.4-0.60.31.00.6-0.00.60.50.7-0.40.40.50.80.60.4
Change in fecal boli incidents, locomotor task0.40.41.80.3-0.10.20.90.2-0.80.50.7-0.30.10.70.30.2-0.9-1.3
Time >=10cm from walls, locomotor time 11.92.13.91.6-1.40.90.81.6-0.91.51.42.0-0.81.91.21.70.81.9
Bouts of movement, locomotor time 14.45.08.52.6-2.62.60.32.0-2.82.32.51.7-2.92.42.62.0-1.70.7
Total resting periods, locomotor time 14.75.28.72.6-2.72.60.62.0-2.72.42.61.7-2.92.42.72.2-1.60.8
Rest time, locomotor task time 10.91.12.01.0-1.00.70.80.6-1.01.21.20.6-1.41.21.40.9-1.4-0.4
Distance moved, locomotor task time 10.30.52.9-0.00.6-0.1-0.60.00.0-0.5-0.70.41.2-0.1-1.1-0.21.70.8
Vertical activity count, locomotor time 10.40.93.6-0.81.1-0.80.1-0.30.7-0.7-0.8-0.01.9-0.3-1.4-0.31.8-0.3
Time >=10cm from walls, locomotor time 20.81.28.60.0-0.0-0.71.00.71.1-0.0-0.40.91.5-0.1-0.70.52.91.4
Bouts of movement, locomotor time 20.50.83.5-0.10.30.4-1.3-0.9-0.6-0.8-0.6-1.4-0.6-0.7-0.1-1.0-1.9-1.1
Total resting periods, locomotor time 20.50.84.4-0.00.10.6-1.2-0.8-0.8-0.6-0.3-1.2-0.9-0.50.1-0.8-2.1-1.2
Rest time, locomotor task time 20.20.21.30.2-0.1-0.21.20.1-0.20.40.40.30.10.60.20.4-0.1-0.9
Distance moved, locomotor task time 20.30.42.00.4-0.10.2-0.40.6-0.10.20.01.0-0.00.1-0.10.51.41.4
Vertical activity count, locomotor time 20.20.31.0-0.60.6-0.30.20.10.8-0.2-0.30.10.9-0.4-0.60.11.0-0.2
Light reinforcement 10.61.48.01.2-1.00.8-1.11.1-0.10.3-0.11.7-0.2-0.10.30.51.92.8
Light reinforcement 20.50.72.7-0.30.8-0.6-0.3-0.51.2-0.8-1.0-0.21.0-0.9-0.9-0.51.70.9
Bone: marrow area2.45.311.02.6-2.83.3-1.02.0-2.82.02.21.6-3.21.72.61.5-2.60.8
Bone: maximum diameter2.75.08.92.7-2.83.00.12.4-2.72.22.41.8-2.52.12.41.9-2.0-0.3
Bone: maximum force0.71.22.21.5-1.51.01.01.5-0.31.21.11.3-1.10.91.20.90.20.8
Bone: maximum moment0.61.01.91.4-1.30.80.71.3-0.21.10.91.2-1.20.81.20.80.21.0
Mean time between licks in bursts0.30.76.1-0.2-0.4-0.52.50.30.60.70.70.60.10.90.70.80.70.6
Mean num. licks in bursts0.81.33.91.4-1.31.8-2.00.9-1.30.60.60.8-1.40.20.80.3-1.11.0
Cd content in liver1.01.15.12.1-0.70.60.11.0-2.30.60.51.00.11.30.20.90.80.3
Co content in liver3.74.311.53.2-2.42.6-0.71.8-3.41.71.72.0-1.52.21.71.3-1.21.6
Cu content in liver1.11.42.2-1.21.5-1.3-0.7-1.11.1-1.3-1.4-0.91.4-1.2-1.5-1.10.9-0.1
Fe content in liver0.70.92.4-0.1-1.11.50.00.50.21.01.30.6-0.90.61.20.9-1.5-0.5
K content in liver0.80.71.8-0.50.8-0.3-1.3-0.60.9-0.9-0.9-0.90.7-1.3-1.0-1.0-0.3-0.4
Mg content in liver0.60.62.5-0.60.60.3-1.6-0.50.5-0.6-0.5-0.80.3-1.0-0.7-0.8-1.0-1.0
Mn content in liver0.20.21.30.4-0.30.3-0.7-0.10.3-0.1-0.10.0-0.7-0.50.3-0.4-0.61.2
Na content in liver0.30.31.50.1-0.20.8-1.20.1-0.50.10.2-0.2-0.7-0.20.30.0-1.2-0.7
Rb content in liver0.40.41.20.5-0.71.1-0.41.1-0.30.70.60.9-0.50.30.41.00.30.0
Se content in liver0.40.41.3-1.01.1-0.9-0.3-0.61.0-0.5-0.4-0.50.6-0.6-0.6-0.30.2-0.3
Sr content in liver1.71.53.01.3-1.20.71.41.4-1.11.31.21.4-0.31.71.01.71.00.4
Zn content in liver1.01.12.3-0.91.4-1.0-0.9-1.10.3-1.2-1.2-1.01.5-0.8-1.5-1.10.5-0.6
Bone: minimum diameter3.15.711.32.8-3.13.1-0.12.3-2.52.32.41.7-3.42.02.91.7-2.30.6
Time in familiar zone, hab. session 10.50.40.90.2-0.80.90.20.6-0.50.80.90.5-0.80.70.70.8-0.6-0.0
Time in novel zone, hab. session 10.30.31.10.7-0.4-0.10.60.70.10.40.20.90.20.20.40.41.01.0
Total zone transitions, hab. session 11.01.55.1-1.71.2-1.10.4-1.21.4-1.0-0.8-1.60.4-1.1-0.7-1.1-0.6-2.3
Total locomotion distance, hab. session 12.12.95.9-2.42.0-2.21.4-1.72.4-1.3-1.1-2.01.0-1.4-1.0-1.3-0.1-2.4
Locomotion velocity, hab. session 12.53.66.8-2.52.3-2.31.0-2.02.4-1.6-1.5-2.31.3-1.7-1.4-1.7-0.2-2.6
Time in familiar zone, hab. session 20.40.41.4-0.2-0.00.3-1.2-0.70.0-0.4-0.3-0.7-0.7-0.50.0-0.7-1.20.4
Time in novel zone, hab. session 20.60.63.40.00.1-0.61.20.80.40.40.20.90.80.3-0.20.91.80.2
Total zone transitions, hab. session 21.41.83.4-1.81.6-1.4-0.5-1.71.7-1.5-1.4-1.60.6-1.6-1.1-1.5-0.0-0.5
Total locomotion distance, hab. session 22.22.95.9-2.42.1-2.30.4-1.92.4-1.7-1.7-1.81.1-1.8-1.3-1.50.6-0.8
Locomotion velocity, hab. session 21.82.45.4-2.11.9-2.30.6-1.72.3-1.5-1.5-1.60.9-1.6-1.1-1.40.6-0.6
Novel to familiar place preference ratio6.57.113.42.1-2.31.03.53.3-1.03.43.13.5-1.82.92.93.71.41.6
Novelty place preference7.78.314.92.5-2.71.53.43.5-1.43.63.43.8-2.23.13.33.91.11.8
Time in novel zone, NPP test6.77.113.52.2-2.41.33.23.3-1.23.43.23.5-2.02.93.03.71.11.5
Total zone transitions, NPP test2.74.06.7-2.12.1-1.6-1.6-2.41.7-2.4-2.3-2.61.0-2.4-1.9-2.4-0.5-1.5
Total locomotion distance, NPP test1.01.32.2-1.31.3-1.3-0.2-1.31.4-1.3-1.2-1.50.5-1.4-0.9-1.3-0.2-1.0
Locomotion velocity, NPP test0.60.91.6-1.01.0-1.20.2-0.91.2-1.1-1.0-1.20.3-1.2-0.6-1.1-0.0-0.7
Intraocular pressure0.91.44.9-1.01.2-1.61.1-0.71.5-0.6-0.7-0.12.2-0.4-1.3-0.32.00.2
Delta distance traveled before/after self-admin0.80.93.21.4-0.91.1-1.00.9-1.10.50.30.9-1.00.40.50.40.31.8
Delta ambulatory time before/after self-admin0.50.63.01.1-0.60.7-0.90.5-0.70.30.10.6-1.20.20.50.20.31.7
Parametrial fat weight0.30.71.21.1-0.70.80.70.5-0.61.01.01.1-0.91.11.00.8-0.60.4
Pavlov. Cond. lever latency0.81.03.20.6-0.70.41.81.2-0.21.31.31.0-0.51.10.81.40.2-0.4
Pavlov. Cond. magazine entry latency0.60.72.4-0.30.30.1-1.6-1.2-0.1-0.9-0.7-1.0-0.5-0.7-0.0-1.3-1.50.4
Pavlov. Cond. change in total contacts2.12.26.6-0.71.0-0.5-2.6-2.00.1-1.8-1.7-1.7-0.0-1.6-0.7-2.3-1.30.9
Pavlov. Cond. index score0.40.52.7-0.10.10.1-1.6-0.8-0.2-0.8-0.8-0.6-0.2-0.6-0.1-1.0-0.70.8
Pavlov. Cond. latency score0.20.31.60.1-0.20.4-1.3-0.5-0.4-0.5-0.4-0.2-0.4-0.20.1-0.6-0.60.9
Pavlov. Cond. lever contacts0.40.52.9-0.30.30.0-1.7-0.9-0.2-0.9-0.8-0.60.2-0.6-0.4-0.9-0.40.7
Pavlov. Cond. magazine entry number1.92.46.60.8-1.20.62.62.2-0.22.11.92.0-0.21.61.02.41.3-0.2
Pavlov. Cond. intertrial magazine entries0.30.31.5-0.60.6-0.5-0.1-0.00.4-0.3-0.4-0.11.1-0.3-0.90.21.2-0.1
Pavlov. Cond. lever-magazine prob. diff.0.70.93.5-0.50.5-0.1-1.9-1.3-0.0-1.2-1.1-1.1-0.0-0.9-0.5-1.4-0.90.6
Pavlov. Cond. response bias1.61.96.2-0.71.0-0.5-2.5-1.90.2-1.9-1.8-1.60.3-1.5-0.9-2.1-0.80.7
Pavlov. Cond. lever latency0.40.53.2-0.3-0.0-0.21.80.50.40.70.70.30.10.50.30.70.1-1.3
Pavlov. Cond. magazine entry latency0.91.12.1-0.51.1-0.9-1.1-1.20.6-1.4-1.4-1.10.6-1.2-1.0-1.50.30.3
Pavlov. Cond. change in total contacts0.71.24.8-0.40.4-0.4-2.0-1.20.4-1.2-1.2-0.8-0.7-1.1-0.2-1.3-0.32.2
Pavlov. Cond. index score0.60.82.7-0.20.7-0.5-1.7-1.10.2-1.2-1.3-0.80.2-1.0-0.7-1.20.11.1
Pavlov. Cond. latency score0.50.72.0-0.20.6-0.5-1.4-1.00.3-1.1-1.2-0.80.1-0.9-0.6-1.10.11.0
Pavlov. Cond. lever contacts0.30.42.80.6-0.30.3-1.5-0.2-0.5-0.4-0.40.1-0.4-0.20.1-0.4-0.11.7
Pavlov. Cond. magazine entry number1.51.93.60.7-1.41.61.11.4-1.11.71.91.0-1.01.51.41.6-1.4-1.3
Pavlov. Cond. intertrial magazine entries0.10.21.0-0.3-0.1-0.30.20.30.60.1-0.10.40.0-0.20.10.30.91.0
Pavlov. Cond. lever-magazine prob. diff.0.81.02.7-0.30.8-0.6-1.7-1.20.3-1.4-1.4-1.00.2-1.1-0.8-1.40.11.1
Pavlov. Cond. response bias0.50.73.10.20.3-0.3-1.6-0.70.0-0.9-1.0-0.30.1-0.7-0.4-0.90.31.8
Time in closed arm before self-admin0.20.20.60.00.4-0.1-0.7-0.5-0.1-0.5-0.5-0.7-0.4-0.7-0.4-0.6-0.20.0
Time in closed arm after self-admin0.10.10.50.40.3-0.30.3-0.4-0.0-0.3-0.4-0.40.1-0.3-0.1-0.40.40.7
Time in open arm before self-admin0.80.93.20.9-0.80.31.81.0-0.61.11.10.9-0.31.40.90.90.30.1
Time in open arm after self-admin0.50.61.2-0.2-1.01.1-0.60.80.40.70.80.6-1.10.20.90.7-1.00.1
Bone: periosteal estimation2.34.89.32.6-2.83.0-0.32.3-2.52.12.21.7-2.81.82.41.6-2.00.2
Bone: periosteal perimeter2.64.49.12.7-2.73.0-0.92.2-2.71.91.91.6-2.71.62.21.5-2.00.5
Bone: post-yield work2.02.95.21.2-1.92.11.11.5-1.22.02.31.0-2.11.61.91.5-2.3-1.0
Progressive ratio test 1 active lever presses0.10.10.40.2-0.20.40.30.0-0.60.00.2-0.1-0.60.30.4-0.1-0.6-0.6
Progressive ratio test 1 breakpoint0.10.20.50.3-0.20.40.30.1-0.60.10.2-0.0-0.70.40.4-0.0-0.6-0.5
Progressive ratio test 1 inactive lever presses0.10.20.50.6-0.3-0.20.10.3-0.70.20.20.1-0.60.40.50.30.20.7
Progressive ratio test 2 active lever presses0.91.01.9-0.91.1-1.0-0.4-1.20.7-1.4-1.4-1.10.6-1.1-1.2-1.40.1-0.9
Progressive ratio test 2 breakpoint1.11.22.2-1.01.2-1.0-0.5-1.30.7-1.5-1.5-1.30.7-1.2-1.3-1.50.1-0.9
Progressive ratio test 2 inactive lever presses0.20.31.2-0.40.5-1.10.7-0.40.5-0.4-0.5-0.4-0.0-0.2-0.3-0.40.4-0.4
Incentive Sensitization - Responses1.62.33.6-1.41.7-1.5-0.8-1.51.3-1.8-1.9-1.51.7-1.7-1.9-1.70.6-0.9
Incentive Sensitization - Breakpoint2.12.74.4-1.51.9-1.6-0.9-1.71.3-2.0-2.1-1.71.8-1.8-2.1-1.90.6-0.9
Sum of active levers in priming session hrs 5-60.80.73.80.9-0.51.2-1.90.1-0.7-0.4-0.50.0-0.9-0.80.0-0.8-0.80.8
Progressive ratio0.40.62.60.7-0.80.40.40.2-0.40.40.50.7-1.20.81.10.3-0.01.6
Food seeking constrained by brief footshock0.40.52.3-0.70.9-1.50.2-0.90.9-0.6-0.7-0.50.4-0.6-0.4-0.60.40.3
Seeking ratio, punishment vs. effort0.20.41.4-0.50.6-0.7-0.3-0.30.4-0.3-0.4-0.60.8-0.7-0.7-0.3-0.2-1.2
Retroperitoneal fat weight0.73.15.9-1.91.9-2.2-0.3-1.82.4-1.7-1.9-1.12.1-1.5-1.7-1.42.01.3
Reaction time number correct1.73.27.1-1.71.9-2.70.8-1.42.7-1.6-1.9-0.81.8-1.7-1.6-1.12.51.4
Reaction time mean minus median0.10.21.0-0.70.20.0-0.1-0.60.1-0.20.1-0.50.30.1-0.1-0.1-1.0-0.9
Reaction time mean minus median AUC0.10.20.7-0.80.2-0.0-0.2-0.60.4-0.4-0.1-0.50.2-0.1-0.1-0.2-0.8-0.7
Reaction time num false alarms1.72.44.5-1.41.7-2.1-0.2-1.51.6-1.9-2.0-1.31.8-1.6-1.6-1.81.20.1
Reaction time num false alarms AUC1.82.94.9-1.41.8-2.2-0.3-1.81.6-2.1-2.2-1.51.8-1.8-1.8-2.01.20.0
Reaction time trials correct on left1.73.27.1-1.71.9-2.70.8-1.42.7-1.6-1.9-0.81.8-1.7-1.6-1.12.51.4
Reaction time trials on left1.83.57.6-1.82.1-2.80.7-1.52.7-1.7-2.0-1.01.8-1.8-1.7-1.32.41.3
Reaction time mean0.50.96.1-0.70.20.4-1.1-1.1-0.5-0.30.1-1.2-0.6-0.10.2-0.4-2.5-1.1
Reaction time mean AUC0.61.06.3-1.00.40.5-1.2-1.2-0.3-0.40.1-1.4-0.4-0.2-0.0-0.5-2.5-1.4
Median of all reaction times0.70.96.5-0.60.30.5-1.3-1.1-0.5-0.30.1-1.3-0.8-0.20.3-0.4-2.5-1.0
Reaction time omissions3.65.311.5-2.82.5-1.1-1.6-3.21.1-2.4-1.8-3.40.7-2.0-1.8-2.6-2.6-3.0
Reaction time false alarm rate0.50.71.8-0.50.8-0.7-0.8-1.00.2-1.1-1.1-1.00.9-0.9-0.9-1.3-0.1-0.5
Reaction time premature initiation rate0.40.62.21.5-1.10.9-0.40.7-0.80.50.40.4-1.00.30.80.2-0.60.4
Reaction time premature initiations0.10.31.30.40.1-0.5-0.0-0.20.7-0.4-0.6-0.10.1-0.6-0.2-0.40.81.1
Std. dev. reaction times0.61.12.5-1.51.0-0.5-0.7-1.40.5-0.9-0.6-1.60.6-0.7-0.7-0.9-1.4-1.5
Reaction time trials completed1.83.57.6-1.82.1-2.80.7-1.52.7-1.7-2.0-1.01.8-1.8-1.7-1.32.41.3
Reaction time trials AUC2.14.08.5-2.12.3-2.90.6-1.72.9-1.9-2.1-1.12.1-1.9-1.8-1.32.51.2
Run reversals in cocaine runway, females2.42.43.91.7-1.61.20.21.7-1.41.81.71.8-1.11.81.41.90.42.0
Run reversals in cocaine runway, males1.01.02.4-0.71.0-0.4-1.5-1.00.1-1.2-1.2-1.00.7-1.1-1.2-1.3-0.4-1.0
Latency to leave start box in cocaine runway2.02.34.4-1.81.6-0.5-1.8-2.10.5-1.5-1.2-2.00.7-1.3-1.1-1.7-1.9-1.5
Latency to leave start box in cocaine runway, F0.81.03.0-1.20.90.2-1.3-1.20.1-0.7-0.5-1.10.2-0.7-0.6-0.9-1.7-1.4
Latency to leave start box in cocaine runway, M0.70.61.7-0.90.8-0.6-0.5-1.30.4-0.9-0.7-1.10.6-0.5-0.4-0.9-1.0-0.7
Std. dev. time between licks in bursts0.40.53.1-0.1-0.4-0.41.8-0.10.50.50.50.2-1.10.51.20.2-0.50.9
Total sessions with >9 infusions0.50.61.91.2-1.00.7-0.10.5-0.90.40.40.3-1.30.61.00.3-0.21.4
Short access day 1 total inactive lever presses0.40.53.11.00.0-0.70.1-0.5-0.4-0.3-0.4-0.3-1.00.10.3-0.40.51.8
Short access day 10 total inactive lever presses0.40.94.00.01.0-2.00.5-0.50.5-0.7-0.9-0.41.5-0.3-0.9-0.51.60.7
Short access day 1 total infusions0.81.14.91.6-1.20.10.20.8-1.10.60.50.4-1.21.01.20.50.32.2
Short access day 10 total infusions0.50.71.80.7-0.80.51.20.4-0.60.70.80.5-1.31.21.30.4-0.70.2
Short access total infusions0.60.71.51.1-1.10.40.90.7-0.70.60.60.5-1.21.01.20.50.11.2
Short access day 1 locomotion0.30.42.30.8-0.4-0.6-0.1-0.0-0.3-0.1-0.1-0.0-1.20.00.6-0.20.11.5
Short access day 10 total locomotion1.32.46.71.9-1.90.91.10.9-0.91.11.01.5-2.41.52.20.6-0.32.6
Short access total locomotion1.41.77.61.7-1.50.50.50.6-0.70.60.41.2-2.21.01.70.40.12.8
One hour access (0.3 mA shock)0.50.63.60.3-0.1-0.1-0.10.60.4-0.1-0.40.70.5-0.2-0.20.11.91.8
Compulsive drug intake0.40.51.51.1-0.71.2-1.20.7-0.90.30.20.2-0.30.20.20.2-0.01.0
One hour access (shock baseline)0.30.41.5-0.2-0.1-0.51.10.40.60.30.11.00.10.30.30.51.20.9
Social response proportion0.70.81.50.5-0.91.2-0.01.1-0.71.01.11.2-0.90.90.71.1-0.3-0.0
Social responses0.10.20.5-0.30.10.1-0.70.40.00.30.30.7-0.10.2-0.10.70.70.6
Social time1.41.83.9-0.1-1.11.31.71.6-0.21.81.91.3-0.91.41.12.0-0.6-1.5
Soleus weight0.61.95.02.2-1.81.9-1.21.1-1.70.60.50.8-2.20.41.30.3-1.11.1
Bone: stiffness0.81.32.41.1-1.61.01.21.3-0.41.31.21.1-1.51.11.50.9-0.30.8
Tibialis anterior weight0.41.49.50.8-0.30.6-3.1-0.3-0.4-0.8-0.90.2-1.1-0.90.1-0.8-0.42.4
Time to tail flick, vehicle, before self-admin0.30.31.3-0.50.5-1.11.1-0.10.5-0.1-0.1-0.30.9-0.2-0.40.00.8-0.5
Time to tail flick, vehicle, after self-admin2.33.15.6-1.52.4-2.1-0.8-2.21.1-2.0-2.0-1.62.2-1.4-2.1-1.81.40.2
Time to tail flick, test, before self-admin0.80.93.4-1.40.9-1.01.3-0.41.8-0.4-0.5-0.30.6-0.8-0.8-0.11.0-0.9
Time to tail flick, test, after self-admin0.50.52.7-0.31.0-0.31.0-0.3-0.4-0.1-0.10.11.10.3-0.80.20.3-1.7
Delta time to tail flick, vehicle, before/after SA2.92.85.3-1.52.2-1.5-1.6-2.30.7-2.1-2.0-1.81.5-1.5-2.0-2.00.3-0.4
Delta time to tail flick, test, before/after SA0.30.31.70.7-0.00.50.10.1-1.30.40.40.40.40.80.10.4-0.2-0.4
Tibia length1.84.99.02.1-2.41.32.42.7-1.12.52.23.0-1.32.62.22.91.61.7
Ambulatory time before self-admin0.40.61.2-0.90.9-0.6-0.3-1.00.2-0.9-0.7-1.00.6-0.6-0.8-0.9-0.4-1.1
Ambulatory time after self-admin0.20.20.70.7-0.10.2-0.7-0.2-0.7-0.4-0.4-0.0-0.8-0.1-0.1-0.60.00.6
Bone: tissue strength3.13.15.6-2.42.2-2.1-0.7-2.02.3-1.9-1.8-1.81.5-1.8-1.7-1.50.5-0.8
Total heroin consumption0.40.51.80.5-0.51.1-1.3-0.0-0.5-0.0-0.00.4-1.0-0.30.4-0.5-1.30.5
Bone: trabecular number0.10.20.60.2-0.50.8-0.70.2-0.40.10.1-0.3-0.60.00.20.1-0.60.1
Bone: trabecular spacing0.71.03.61.3-0.5-0.51.61.00.20.60.41.40.40.50.40.81.91.3
Bone: trabecular thickness0.50.62.80.3-0.71.0-0.7-0.0-0.60.30.4-0.2-1.60.20.90.0-1.7-0.1
Bone: trabecular tissue density0.60.94.11.1-0.71.0-0.70.2-1.10.60.70.4-2.00.41.10.2-1.70.1
Water consumed over 24 hours2.02.74.9-1.71.6-0.9-2.2-1.71.3-2.0-1.9-2.01.2-2.0-1.9-1.8-0.1-1.0
Number of responses in last shaping day0.60.62.60.9-0.80.40.10.5-0.50.70.70.3-1.10.61.20.5-0.21.6