Hub : Genes

Dbnl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Dbnl 0.51 0.17 4.6e-10 0.27 0.31 0.32 0.35 3.3e-07 3.7e-08 1.9e-08 2.4e-09
2 Adipose alternative TSS NM_001277211.1 0.06 0.04 7.7e-09 0.07 0.06 0.06 0.06 8.1e-08 1.3e-07 9.9e-08 2.0e-07
3 Adipose alternative TSS XM_039092498.1 0.06 0.04 1.1e-08 0.06 0.06 0.06 0.06 9.4e-08 1.5e-07 1.2e-07 2.1e-07
4 Liver mRNA stability Dbnl 0.18 0.09 0.0e+00 0.19 0.2 0.19 0.2 4.3e-21 3.7e-21 9.4e-21 2.0e-21
5 Liver isoform ratio NM_001277211.1 0.02 0.02 9.6e-03 0 0 0 0 1.2e-01 9.2e-02 3.7e-01 2.2e-01
6 OFC mRNA stability Dbnl 0.15 0.11 3.0e-03 0.05 0.06 0.03 0.04 2.3e-02 1.6e-02 6.3e-02 3.5e-02
7 Brain alternative TSS NM_001277211.1 0.1 0.06 1.4e-13 0.15 0.15 0.14 0.15 8.9e-14 4.1e-14 2.0e-13 1.5e-13
8 Adipose isoform ratio XM_039092498.1 0.06 0.04 8.1e-09 0.06 0.07 0.07 0.06 1.3e-07 7.4e-08 8.7e-08 1.8e-07
9 Liver gene expression Dbnl 0.13 0.06 0.0e+00 0.12 0.17 0.17 0.16 8.8e-14 9.5e-19 5.0e-18 6.8e-18
10 Brain isoform ratio XM_039092498.1 0.1 0.06 1.7e-12 0.13 0.13 0.12 0.13 3.7e-12 2.7e-12 3.3e-11 9.7e-12
11 Brain mRNA stability Dbnl 0.06 0.06 3.6e-05 0.05 0.05 0.04 0.05 1.3e-05 1.7e-05 8.0e-05 2.2e-05
12 Brain alternative TSS XM_039092498.1 0.11 0.06 1.9e-13 0.15 0.15 0.14 0.15 1.6e-13 5.0e-14 3.3e-13 1.5e-13
13 NAcc mRNA stability Dbnl 0.03 0.03 2.4e-03 0.01 0.01 0.01 0.01 5.9e-02 7.5e-03 1.2e-02 2.8e-02
14 PL mRNA stability Dbnl 0.05 0.04 4.8e-04 0.03 0.02 0.04 0.02 2.5e-04 2.3e-03 1.1e-05 2.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.00.10.4-0.5-0.20.2-0.20.1-0.30.2-0.10.1-0.20.1-0.2-0.30.6
Area under the delay curve3.13.34.91.51.8-1.81.8-2.21.7-1.92.1-2.01.9-1.81.91.3-1.6
BMI with tail0.00.00.40.0-0.00.00.1-0.20.1-0.20.2-0.20.20.00.2-0.00.6
BMI without tail0.00.10.5-0.2-0.30.3-0.00.1-0.10.0-0.10.0-0.00.1-0.0-0.20.7
Body weight1.25.27.02.02.2-2.22.4-2.62.2-2.42.5-2.52.4-2.22.51.7-1.5
Weight adjusted by age0.30.30.50.70.7-0.70.6-0.70.6-0.60.6-0.60.6-0.50.60.5-0.0
Bone surface0.20.40.70.60.8-0.80.7-0.50.7-0.60.6-0.60.6-0.70.60.80.2
Bone volume0.20.40.60.50.8-0.80.7-0.60.7-0.70.7-0.70.7-0.80.70.70.1
Breakpoint value in progressive ratio session1.41.53.51.31.2-1.21.2-1.21.1-1.21.2-1.21.2-1.11.21.0-1.9
Number of licking bursts2.93.43.81.91.9-1.91.9-1.91.9-1.91.9-1.91.9-1.91.91.7-1.3
Context. condit. distance diff. score3.54.35.2-1.9-2.22.2-2.02.3-1.92.1-2.12.1-2.01.9-2.0-1.72.3
Locomotion velocity, session 10.10.10.50.30.2-0.20.00.30.10.1-0.20.2-0.2-0.3-0.20.3-0.7
Locomotion distance, session 10.60.82.5-1.6-0.90.9-1.00.3-1.10.7-0.50.5-0.70.6-0.7-1.40.9
Locomotion velocity, session 20.10.10.70.60.5-0.50.30.30.4-0.1-0.10.10.0-0.4-0.00.80.1
Locomotion distance, session 20.91.32.8-1.7-1.01.0-1.11.0-1.21.1-1.01.0-1.10.8-1.0-1.21.3
Locomotion velocity, session 32.02.43.6-1.9-1.51.5-1.51.5-1.51.5-1.51.4-1.51.3-1.5-1.51.8
Locomotion distance, session 30.50.50.90.20.7-0.70.8-0.60.6-0.70.7-0.80.7-0.90.70.60.9
Stereotopy head waving bouts, day 30.70.91.5-1.2-1.01.0-0.90.8-0.90.8-0.80.8-0.81.0-0.8-1.01.2
Stereotopy head waving duration, day 32.02.42.8-1.5-1.71.7-1.61.6-1.61.6-1.61.6-1.61.6-1.6-1.51.1
Locomotion velocity, session 70.30.30.40.50.5-0.50.6-0.40.6-0.50.5-0.50.5-0.60.50.60.3
Locomotion distance, session 70.20.21.5-0.4-0.40.4-0.20.5-0.30.4-0.40.4-0.40.2-0.4-0.21.2
Stereotopy head waving bouts, day 70.70.71.1-0.5-0.80.8-0.91.0-0.80.9-1.01.0-0.90.8-1.0-0.60.4
Stereotopy head waving duration, day 70.10.10.1-0.3-0.30.3-0.40.2-0.30.3-0.20.2-0.30.2-0.3-0.30.3
Locomotion velocity, session 81.21.44.9-0.8-0.90.9-1.01.5-0.91.1-1.31.3-1.20.8-1.2-0.52.2
Locomotion distance, session 87.010.211.2-3.3-3.33.3-3.23.3-3.13.2-3.33.2-3.22.7-3.2-2.93.3
Degree of sensitization distance2.52.53.3-1.1-1.61.6-1.61.8-1.51.7-1.81.8-1.71.7-1.7-1.20.9
Degree of sensitization stereotypy0.00.00.30.4-0.00.00.0-0.00.1-0.00.00.00.0-0.20.00.2-0.5
Conditioned locomotion1.01.23.0-1.7-1.21.2-1.10.5-1.30.9-0.70.7-0.91.1-0.8-1.61.1
Cocaine response after cond. corrected1.31.42.11.41.2-1.21.1-1.21.2-1.21.2-1.21.2-1.11.21.1-1.2
Cocaine response after cond. not corrected1.41.51.91.41.2-1.21.1-1.31.2-1.21.3-1.21.2-1.21.21.1-1.3
Cocaine response before conditioning0.40.40.8-0.9-0.70.7-0.70.5-0.70.6-0.60.6-0.60.6-0.6-0.80.3
Saline control response0.40.51.5-0.7-0.70.7-0.60.9-0.50.6-0.70.7-0.60.6-0.6-0.41.2
Bone: connectivity density0.20.30.7-0.6-0.50.5-0.50.5-0.50.5-0.40.4-0.50.4-0.5-0.40.8
Bone: cortical apparent density0.70.91.11.00.9-0.91.0-0.91.0-0.90.9-0.90.9-1.10.90.9-1.0
Bone: cortical area2.94.35.01.92.2-2.22.1-2.22.0-2.12.2-2.22.1-2.12.11.8-1.9
Bone: cortical porosity0.00.00.10.10.1-0.10.0-0.20.1-0.20.2-0.20.2-0.10.20.0-0.1
Bone: cortical porosity0.10.20.2-0.4-0.40.4-0.50.3-0.40.4-0.40.4-0.40.4-0.4-0.50.1
Bone: cortical thickness1.83.03.91.41.9-1.91.7-2.01.6-1.81.9-1.91.8-1.71.81.3-1.4
Bone: cortical thickness0.50.51.4-1.2-0.80.8-0.80.4-0.90.7-0.50.5-0.70.8-0.6-1.00.2
Bone: cortical tissue density0.71.01.21.11.0-1.01.1-0.91.0-1.00.9-0.91.0-1.11.01.0-1.0
Condit. Reinf. active minus inactive responses1.31.41.81.31.1-1.11.3-1.01.3-1.31.2-1.21.3-1.31.31.3-0.5
Condit. Reinf. active-inactive response ratio0.20.20.80.90.2-0.20.40.30.5-0.2-0.10.10.2-0.30.10.9-0.2
Condit. Reinf. active responses0.70.81.20.80.9-0.91.0-0.80.9-1.00.9-0.91.0-1.11.00.9-0.1
Condit. Reinf. inactive responses0.30.40.70.00.7-0.70.6-0.90.4-0.70.8-0.80.7-0.80.70.20.4
Incentive salience index mean1.72.02.51.31.3-1.31.5-1.51.5-1.61.6-1.61.6-1.51.61.3-0.5
Condit. Reinf. lever presses0.50.61.40.10.7-0.70.7-1.20.6-0.91.1-1.10.9-0.71.00.20.4
Condit. Reinf. active minus inactive responses0.40.50.7-0.8-0.70.7-0.70.6-0.70.7-0.70.7-0.70.8-0.7-0.60.6
Condit. Reinf. active-inactive response ratio0.00.00.0-0.2-0.00.0-0.0-0.2-0.1-0.10.1-0.10.10.20.1-0.20.1
Condit. Reinf. active responses0.50.71.1-0.9-0.90.9-0.90.8-0.90.9-0.80.8-0.91.0-0.9-0.80.5
Condit. Reinf. inactive responses0.81.01.4-0.8-1.01.0-1.01.2-0.91.1-1.11.1-1.11.0-1.1-0.70.6
Condit. Reinf. lever presses0.40.50.7-0.9-0.80.8-0.70.7-0.70.7-0.70.7-0.70.8-0.7-0.60.8
Condit. Reinf. lever reinforcers received0.40.60.8-0.9-0.80.8-0.80.7-0.80.7-0.70.7-0.70.9-0.7-0.70.6
Conditioned reinforcement - actives0.10.10.7-0.00.1-0.10.0-0.0-0.00.00.0-0.00.00.00.0-0.0-0.9
Conditioned reinforcement - inactives0.10.10.40.20.3-0.30.2-0.20.2-0.20.2-0.20.1-0.30.10.2-0.7
Conditioned locomotion0.10.10.8-0.00.1-0.10.1-0.30.0-0.20.2-0.30.2-0.10.2-0.1-0.9
Patch foraging indifference point 0 sec1.93.15.32.31.7-1.71.9-1.32.0-1.81.6-1.61.8-2.11.72.1-0.6
Patch foraging indifference point AUC0.20.20.50.60.4-0.40.4-0.20.5-0.40.3-0.30.4-0.50.30.7-0.3
Delay disc. indifference point, 0s delay0.60.70.90.90.9-0.90.8-1.00.8-0.80.9-0.90.8-0.80.80.7-0.5
Delay disc. indifference point, 16s delay2.72.73.11.71.6-1.61.7-1.81.6-1.71.7-1.71.7-1.71.71.4-1.3
Delay disc. indifference point, 2s delay0.91.02.10.40.8-0.80.9-1.50.8-1.11.3-1.31.1-1.11.20.4-0.6
Delay disc. indifference point, 24s delay1.71.62.01.11.1-1.11.4-1.41.2-1.31.4-1.41.3-1.41.41.0-1.1
Delay disc. indifference point, 4s delay2.82.94.71.31.6-1.61.7-2.21.5-1.82.0-2.01.8-1.61.91.1-1.6
Delay disc. indifference point, 8s delay1.01.01.90.71.1-1.10.9-1.40.9-1.11.2-1.21.1-0.91.10.6-1.0
Indifference point function ln k0.00.00.3-0.50.1-0.1-0.0-0.3-0.2-0.00.1-0.10.00.10.1-0.40.3
Indifference point function log k0.00.00.3-0.50.1-0.1-0.0-0.3-0.2-0.00.1-0.10.00.10.1-0.40.3
Patch foraging total patch changes 0 sec2.13.45.82.41.8-1.82.0-1.32.1-1.81.6-1.61.8-2.21.82.3-0.6
Patch foraging total patch changes 12 sec1.21.63.21.81.2-1.21.4-0.81.5-1.31.1-1.11.3-1.41.21.6-0.6
Patch foraging total patch changes 18 sec2.22.85.52.31.6-1.61.8-1.11.9-1.61.3-1.41.6-1.91.52.2-1.2
Patch foraging total patch changes 24 sec0.60.82.0-0.2-1.01.0-0.71.4-0.50.8-1.11.1-0.80.4-0.9-0.11.1
Patch foraging total patch changes 6 sec2.43.65.12.31.9-1.92.0-1.42.1-1.91.7-1.71.9-2.21.92.3-0.8
Patch foraging time to switch 0 sec0.60.91.2-0.9-1.11.1-1.00.8-1.00.9-0.90.9-0.91.0-0.9-1.10.3
Patch foraging water rate 0 sec2.13.44.42.11.9-1.92.0-1.52.0-1.91.7-1.81.9-2.11.92.1-0.8
Patch foraging water rate 12 sec0.10.20.30.30.5-0.50.5-0.40.4-0.40.4-0.40.4-0.50.40.40.3
Patch foraging water rate 18 sec0.20.21.1-0.9-0.50.5-0.4-0.3-0.60.20.0-0.0-0.20.3-0.1-1.1-0.1
Patch foraging water rate 24 sec0.10.10.40.20.3-0.30.2-0.30.2-0.20.3-0.20.2-0.30.20.2-0.7
Patch foraging water rate 6 sec0.30.40.90.20.7-0.70.6-0.90.5-0.70.8-0.80.7-0.60.70.3-0.6
Seeking ratio, delayed vs. immediate footshock0.50.51.4-0.9-0.90.9-0.80.1-0.90.6-0.40.4-0.60.9-0.5-1.2-0.4
Distance traveled before self-admin0.20.20.60.80.4-0.40.5-0.20.5-0.40.3-0.30.4-0.50.30.60.4
Distance traveled after self-admin0.20.20.40.30.3-0.30.5-0.60.4-0.50.6-0.60.5-0.50.50.2-0.4
Extensor digitorum longus weight3.212.613.93.63.6-3.63.6-3.63.6-3.73.7-3.73.7-3.73.73.4-2.6
Bone: elastic displacement0.70.80.8-0.9-0.90.9-0.90.9-0.90.9-0.90.9-0.90.9-0.9-0.90.6
Bone: elastic work0.00.00.1-0.2-0.10.10.1-0.3-0.0-0.10.2-0.20.1-0.10.2-0.30.1
Bone: endosteal estimation0.00.10.20.50.1-0.10.3-0.20.3-0.30.2-0.20.2-0.30.20.3-0.4
Bone: endosteal perimeter0.51.12.60.90.9-0.90.9-1.30.9-1.01.1-1.11.0-0.91.00.6-1.6
Epididymis fat weight0.40.81.3-1.1-0.80.8-0.90.9-0.90.9-0.90.9-0.90.8-0.9-0.91.1
Delta time in closed arm before/after self-admin7.16.98.4-2.9-2.72.7-2.82.4-2.82.7-2.62.6-2.72.7-2.7-2.81.7
Delta time in open arm before/after self-admin7.97.611.23.32.9-2.92.9-2.62.9-2.82.7-2.72.8-2.82.82.8-1.5
Diff in mean of infusions in LGA sessions0.30.30.7-0.6-0.80.8-0.50.4-0.70.5-0.40.5-0.50.5-0.5-0.8-0.1
Delay discount exponential model param2.83.04.5-1.4-1.71.7-1.72.1-1.61.8-2.01.9-1.81.7-1.8-1.21.5
Extinction: sum of active levers before priming0.60.61.20.70.7-0.70.8-0.80.7-0.80.8-0.80.8-0.80.80.7-1.1
Active lever presses in extinction session 60.10.10.70.10.1-0.10.2-0.40.0-0.20.2-0.20.2-0.10.2-0.1-0.9
Bone: final force0.40.71.00.90.9-0.90.9-0.70.9-0.90.8-0.80.9-1.00.90.9-0.5
Bone: final moment0.61.01.21.01.0-1.01.1-0.91.0-1.01.0-1.01.0-1.11.01.0-0.6
Food consumed during 24 hour testing period2.22.73.71.91.8-1.81.7-1.31.8-1.61.5-1.51.6-1.71.61.9-1.1
Glucose17.926.943.16.65.7-5.75.4-3.95.6-4.84.4-4.44.8-5.24.76.3-4.4
Heart weight0.20.30.8-0.3-0.40.4-0.30.9-0.30.5-0.70.7-0.50.3-0.60.00.8
Delay discount hyperbolic model param3.03.14.8-1.4-1.71.7-1.82.2-1.61.9-2.02.0-1.91.7-1.9-1.21.5
Intermittent access intake day 1-15 change0.50.51.20.90.8-0.80.7-0.30.8-0.60.5-0.50.7-0.80.61.1-0.7
Intermittent access intake escalation0.30.30.80.70.6-0.60.5-0.10.6-0.40.3-0.30.4-0.60.40.9-0.5
Intermittent access intake escalation 20.20.20.90.80.5-0.50.50.10.6-0.30.1-0.10.3-0.50.30.90.1
Intermitt. access day 1 inactive lever presses0.70.72.0-1.4-0.90.9-0.80.4-1.00.8-0.60.6-0.70.7-0.7-1.10.4
Intermitt. access day 15 inactive lever presses1.21.31.61.21.1-1.11.2-1.11.3-1.21.2-1.21.2-1.21.21.2-0.5
Intermitt. access escalation Index0.30.30.70.80.5-0.50.5-0.10.6-0.50.3-0.30.5-0.50.50.80.0
Intermittent access day 1 total infusions0.30.30.5-0.5-0.70.7-0.60.4-0.60.6-0.50.5-0.60.6-0.6-0.7-0.5
Intermittent access day 15 total infusions0.20.20.80.60.4-0.40.4-0.20.4-0.30.3-0.30.3-0.40.30.5-0.9
Intermittent access terminal intake (last 3 days)0.10.10.50.70.3-0.30.20.10.4-0.20.0-0.10.2-0.30.10.6-0.6
Intermittent access total infusions0.00.00.60.30.0-0.00.1-0.00.1-0.10.0-0.00.1-0.10.00.1-0.8
Intermittent access day 1 locomotion1.11.12.2-1.5-1.11.1-1.10.7-1.31.1-0.90.9-1.01.1-1.0-1.4-0.3
Intermittent access day 15 total locomotion0.30.31.80.20.4-0.40.4-0.60.3-0.40.5-0.50.4-0.40.40.1-1.3
Intermittent access total locomotion0.30.31.80.20.4-0.40.4-0.60.3-0.40.5-0.50.4-0.40.50.1-1.4
Intermittent access standard deviation1.21.32.4-0.8-1.11.1-1.11.6-0.91.2-1.41.4-1.21.0-1.2-0.51.1
Left kidney weight0.10.20.8-0.8-0.70.7-0.4-0.1-0.60.3-0.10.2-0.30.3-0.3-0.9-0.4
Right kidney weight1.02.74.6-2.1-1.81.8-1.71.2-1.91.6-1.41.4-1.61.7-1.5-2.10.8
Cocaine induced anxiety3.43.94.91.92.2-2.22.1-1.92.0-2.02.0-2.02.0-2.02.01.9-1.1
Post-drug Anxiety1.11.21.71.11.3-1.31.2-1.01.1-1.11.1-1.01.1-1.21.01.1-0.5
Baseline Anxiety0.30.30.5-0.5-0.70.7-0.60.5-0.60.6-0.60.6-0.60.5-0.6-0.5-0.1
Tail length1.13.44.31.81.7-1.72.0-2.11.8-2.02.0-2.02.0-2.12.01.4-1.4
Length with tail1.86.78.72.42.5-2.52.6-3.02.4-2.72.8-2.82.7-2.72.71.9-2.5
Length without tail1.22.53.41.51.6-1.61.5-1.81.5-1.61.7-1.61.6-1.41.61.3-1.8
Times rat made contact with spout0.30.31.51.00.6-0.60.40.70.50.0-0.40.4-0.1-0.6-0.21.20.1
Lifetime Intake0.00.00.50.30.0-0.00.1-0.10.1-0.10.1-0.10.1-0.10.10.1-0.7
Liver weight, left2.53.95.4-2.2-2.22.2-2.01.6-2.12.0-1.81.9-2.02.2-1.9-2.30.9
Liver weight, right4.37.111.8-3.4-2.72.7-2.91.9-3.12.6-2.32.3-2.62.9-2.6-3.40.9
Locomotor activity0.50.92.91.70.7-0.70.8-0.41.1-0.80.6-0.60.7-0.60.71.3-1.3
Locomotor testing distance0.10.10.30.50.2-0.20.3-0.50.4-0.40.4-0.40.4-0.20.40.2-0.4
Locomotor testing rearing1.82.84.42.11.7-1.71.7-1.41.8-1.71.6-1.61.7-1.61.71.9-1.3
Locomotion in novel chamber5.16.37.0-2.6-2.22.2-2.52.6-2.62.6-2.62.6-2.62.5-2.7-2.32.3
Locomotion in novel chamber post-restriction2.93.54.1-2.0-1.71.7-1.91.8-2.02.0-1.91.9-2.01.9-2.0-1.91.4
Fecal boli incidents, locomotor time 10.20.20.5-0.6-0.50.5-0.50.4-0.50.5-0.40.4-0.50.7-0.5-0.60.2
Change in fecal boli incidents, locomotor task0.10.10.50.70.2-0.20.30.10.4-0.30.1-0.10.3-0.30.20.70.4
Time >=10cm from walls, locomotor time 10.20.20.4-0.4-0.10.1-0.50.5-0.40.5-0.50.6-0.50.6-0.6-0.20.1
Bouts of movement, locomotor time 10.60.71.81.40.9-0.90.7-0.30.9-0.70.5-0.50.6-0.50.61.2-1.1
Total resting periods, locomotor time 10.30.31.10.90.6-0.60.4-0.10.6-0.40.2-0.20.4-0.30.30.9-1.0
Rest time, locomotor task time 10.00.10.20.30.4-0.40.00.10.20.0-0.00.0-0.00.2-0.00.4-0.2
Distance moved, locomotor task time 10.20.20.50.20.2-0.20.5-0.70.3-0.50.6-0.60.6-0.60.60.1-0.6
Vertical activity count, locomotor time 10.10.10.20.20.0-0.00.3-0.30.2-0.20.3-0.20.2-0.30.30.0-0.5
Time >=10cm from walls, locomotor time 20.70.71.2-0.9-0.80.8-1.00.5-0.90.9-0.80.8-0.91.1-0.9-1.0-0.1
Bouts of movement, locomotor time 20.20.20.7-0.5-0.20.20.1-0.8-0.0-0.50.6-0.70.5-0.40.6-0.6-0.4
Total resting periods, locomotor time 20.20.20.7-0.3-0.00.00.2-0.90.1-0.60.7-0.70.6-0.50.7-0.4-0.3
Rest time, locomotor task time 20.00.00.30.1-0.10.1-0.10.30.00.1-0.20.2-0.10.1-0.10.20.6
Distance moved, locomotor task time 20.10.10.2-0.4-0.20.2-0.40.3-0.40.4-0.40.4-0.40.5-0.4-0.4-0.0
Vertical activity count, locomotor time 20.20.20.5-0.5-0.00.0-0.50.4-0.50.6-0.50.5-0.60.7-0.6-0.4-0.0
Light reinforcement 10.10.20.30.10.4-0.40.4-0.60.3-0.50.5-0.50.5-0.30.50.2-0.1
Light reinforcement 20.10.10.4-0.4-0.00.0-0.1-0.6-0.2-0.10.3-0.30.10.10.1-0.7-0.4
Bone: marrow area0.00.00.20.40.0-0.00.2-0.10.2-0.10.1-0.10.1-0.20.10.2-0.4
Bone: maximum diameter4.88.810.03.23.1-3.13.0-2.93.0-3.02.9-2.92.9-3.02.92.9-2.6
Bone: maximum force0.30.50.70.70.7-0.70.8-0.70.7-0.70.7-0.70.7-0.80.70.6-0.4
Bone: maximum moment0.40.80.90.80.9-0.90.9-0.90.9-0.90.9-0.90.9-1.00.90.7-0.5
Mean time between licks in bursts0.50.81.61.30.9-0.90.9-0.40.9-0.70.5-0.50.7-1.00.61.1-1.2
Mean num. licks in bursts1.82.14.1-1.0-1.31.3-1.42.0-1.21.6-1.81.8-1.61.2-1.7-0.71.2
Cd content in liver0.30.30.5-0.6-0.70.7-0.50.4-0.60.5-0.40.4-0.50.6-0.5-0.70.5
Co content in liver0.10.10.60.20.1-0.10.3-0.10.3-0.40.3-0.30.4-0.30.40.30.8
Cu content in liver0.50.60.80.90.8-0.80.8-0.60.8-0.80.7-0.70.8-0.70.80.9-0.4
Fe content in liver0.10.20.3-0.4-0.40.4-0.40.5-0.40.5-0.50.5-0.50.2-0.5-0.3-0.0
K content in liver0.40.41.30.00.7-0.70.5-1.10.4-0.70.9-0.90.7-0.50.70.0-0.4
Mg content in liver0.40.40.50.40.7-0.70.6-0.70.6-0.70.7-0.70.7-0.70.70.50.0
Mn content in liver0.10.20.5-0.40.3-0.30.2-0.70.1-0.40.6-0.60.4-0.20.5-0.20.3
Na content in liver4.14.35.42.32.3-2.32.1-2.02.1-2.12.0-2.02.0-2.12.02.1-1.5
Rb content in liver2.63.23.81.81.8-1.81.8-1.91.8-1.91.9-1.91.9-1.71.91.7-1.1
Se content in liver1.62.02.71.11.4-1.41.4-1.71.4-1.51.6-1.61.5-1.41.61.1-0.6
Sr content in liver1.91.72.11.41.3-1.31.4-1.31.3-1.31.3-1.31.3-1.41.31.2-1.1
Zn content in liver0.30.30.80.20.6-0.60.5-0.90.4-0.60.7-0.70.6-0.50.70.1-0.3
Bone: minimum diameter0.00.00.1-0.2-0.10.1-0.1-0.1-0.20.1-0.00.0-0.10.0-0.1-0.3-0.2
Time in familiar zone, hab. session 10.10.10.5-0.3-0.20.2-0.10.3-0.20.2-0.20.2-0.20.1-0.2-0.30.7
Time in novel zone, hab. session 10.20.20.50.70.4-0.40.4-0.30.5-0.40.4-0.30.4-0.30.40.6-0.5
Total zone transitions, hab. session 10.00.10.2-0.00.4-0.40.1-0.20.1-0.10.2-0.20.1-0.40.10.20.4
Total locomotion distance, hab. session 10.10.20.4-0.10.5-0.50.3-0.60.2-0.30.5-0.50.3-0.40.4-0.00.2
Locomotion velocity, hab. session 10.00.00.1-0.20.3-0.3-0.0-0.3-0.0-0.10.2-0.20.1-0.20.1-0.1-0.2
Time in familiar zone, hab. session 21.71.82.5-1.2-1.61.6-1.31.3-1.41.4-1.41.4-1.31.3-1.3-1.40.6
Time in novel zone, hab. session 22.62.63.51.71.9-1.91.6-1.41.7-1.61.6-1.61.6-1.61.61.8-0.7
Total zone transitions, hab. session 20.91.21.90.51.3-1.31.0-1.40.9-1.11.3-1.21.1-1.31.10.70.1
Total locomotion distance, hab. session 21.21.62.40.71.5-1.51.2-1.51.1-1.31.4-1.41.3-1.51.30.9-0.1
Locomotion velocity, hab. session 21.41.93.10.71.6-1.61.3-1.81.2-1.41.6-1.61.4-1.51.50.8-0.4
Novel to familiar place preference ratio0.50.51.21.10.8-0.80.7-0.50.8-0.60.5-0.50.5-0.60.51.0-0.8
Novelty place preference0.60.61.31.10.9-0.90.7-0.50.8-0.60.5-0.50.5-0.60.51.1-0.9
Time in novel zone, NPP test0.60.61.31.20.9-0.90.7-0.40.9-0.60.5-0.50.5-0.60.51.1-0.8
Total zone transitions, NPP test0.30.51.7-1.3-0.50.5-0.70.1-0.80.5-0.30.3-0.50.3-0.4-1.10.9
Total locomotion distance, NPP test0.10.10.8-0.9-0.10.1-0.3-0.4-0.40.10.1-0.1-0.1-0.10.0-0.80.0
Locomotion velocity, NPP test0.10.10.5-0.70.1-0.1-0.1-0.6-0.2-0.10.4-0.40.2-0.20.2-0.6-0.2
Intraocular pressure0.40.50.70.80.7-0.70.7-0.60.8-0.70.7-0.70.7-0.60.70.8-0.7
Delta distance traveled before/after self-admin0.20.30.9-0.9-0.60.6-0.50.1-0.60.4-0.30.3-0.40.5-0.3-0.8-0.3
Delta ambulatory time before/after self-admin0.40.51.4-1.2-0.80.8-0.70.3-0.80.6-0.50.5-0.60.6-0.5-0.9-0.2
Parametrial fat weight2.03.86.42.11.9-1.91.9-1.91.9-1.91.9-1.91.9-2.01.91.8-2.5
Pavlov. Cond. lever latency0.50.61.51.20.7-0.70.8-0.40.8-0.60.5-0.50.6-0.60.61.0-1.1
Pavlov. Cond. magazine entry latency1.82.34.2-1.9-1.41.4-1.51.4-1.51.4-1.41.4-1.41.4-1.4-1.52.0
Pavlov. Cond. change in total contacts1.41.52.01.01.2-1.21.3-1.31.2-1.31.4-1.41.3-1.41.41.10.5
Pavlov. Cond. index score1.92.44.2-2.1-1.51.5-1.51.3-1.61.4-1.31.3-1.41.4-1.3-1.72.0
Pavlov. Cond. latency score1.62.03.7-1.9-1.41.4-1.41.1-1.51.3-1.21.2-1.31.2-1.2-1.61.8
Pavlov. Cond. lever contacts0.60.82.5-1.3-0.90.9-0.80.5-0.90.6-0.50.5-0.60.5-0.6-1.11.6
Pavlov. Cond. magazine entry number1.82.35.71.81.4-1.41.4-1.51.4-1.41.4-1.41.4-1.31.41.3-2.4
Pavlov. Cond. intertrial magazine entries0.30.31.10.10.4-0.40.4-1.00.2-0.50.7-0.70.5-0.30.6-0.3-0.6
Pavlov. Cond. lever-magazine prob. diff.2.22.84.9-2.2-1.61.6-1.61.4-1.71.5-1.41.4-1.51.5-1.5-1.82.2
Pavlov. Cond. response bias0.81.04.5-1.4-0.80.8-0.80.7-0.90.7-0.70.6-0.70.7-0.7-1.02.1
Pavlov. Cond. lever latency3.24.36.51.72.1-2.12.0-2.51.9-2.22.3-2.32.2-2.02.21.4-1.9
Pavlov. Cond. magazine entry latency0.00.00.1-0.20.1-0.1-0.10.1-0.00.1-0.10.1-0.10.1-0.10.10.4
Pavlov. Cond. change in total contacts0.20.30.5-0.4-0.50.5-0.60.7-0.50.6-0.70.7-0.60.6-0.6-0.40.3
Pavlov. Cond. index score1.21.62.1-1.2-1.21.2-1.21.4-1.21.3-1.41.4-1.31.3-1.3-0.91.1
Pavlov. Cond. latency score1.31.61.9-1.3-1.21.2-1.21.4-1.21.3-1.31.3-1.31.3-1.3-1.01.2
Pavlov. Cond. lever contacts2.83.95.7-1.6-2.02.0-1.92.4-1.82.1-2.22.2-2.11.9-2.1-1.41.4
Pavlov. Cond. magazine entry number0.00.10.2-0.2-0.10.1-0.0-0.4-0.1-0.10.2-0.20.10.00.1-0.5-0.3
Pavlov. Cond. intertrial magazine entries0.00.00.00.0-0.00.00.1-0.20.1-0.20.2-0.20.2-0.10.2-0.0-0.1
Pavlov. Cond. lever-magazine prob. diff.1.21.52.0-1.2-1.21.2-1.21.4-1.11.3-1.31.3-1.31.2-1.3-0.91.2
Pavlov. Cond. response bias1.21.62.8-0.8-1.21.2-1.21.7-1.11.4-1.51.5-1.41.2-1.4-0.70.8
Time in closed arm before self-admin0.40.50.91.00.7-0.70.7-0.50.7-0.60.6-0.60.6-0.60.60.7-0.8
Time in closed arm after self-admin2.02.12.4-1.5-1.61.6-1.61.4-1.51.5-1.41.4-1.51.4-1.5-1.50.8
Time in open arm before self-admin2.62.84.2-2.1-1.81.8-1.61.6-1.71.7-1.61.7-1.71.6-1.7-1.61.0
Time in open arm after self-admin0.10.20.40.60.4-0.40.5-0.30.4-0.40.4-0.40.4-0.40.40.4-0.1
Bone: periosteal estimation0.81.72.01.41.3-1.31.3-1.41.3-1.31.3-1.31.3-1.31.31.1-1.3
Bone: periosteal perimeter1.72.84.31.51.7-1.71.6-1.91.5-1.71.8-1.81.7-1.61.71.2-2.1
Bone: post-yield work0.20.20.30.50.6-0.60.5-0.50.5-0.50.5-0.50.4-0.30.40.5-0.4
Progressive ratio test 1 active lever presses0.00.00.60.0-0.10.1-0.0-0.0-0.10.0-0.00.0-0.00.1-0.0-0.1-0.8
Progressive ratio test 1 breakpoint0.20.20.2-0.4-0.50.5-0.40.3-0.50.4-0.40.4-0.40.5-0.4-0.5-0.5
Progressive ratio test 1 inactive lever presses2.32.54.21.11.4-1.41.5-2.01.3-1.71.9-1.81.7-1.61.70.9-1.7
Progressive ratio test 2 active lever presses0.00.10.60.20.1-0.10.00.10.00.0-0.10.1-0.1-0.0-0.10.1-0.8
Progressive ratio test 2 breakpoint0.10.10.60.30.1-0.10.10.00.1-0.0-0.00.00.0-0.10.00.2-0.8
Progressive ratio test 2 inactive lever presses0.70.82.60.70.8-0.80.8-0.90.7-0.80.9-0.90.8-0.70.80.6-1.6
Incentive Sensitization - Responses0.00.00.30.30.2-0.20.10.10.1-0.0-0.10.10.0-0.1-0.00.3-0.6
Incentive Sensitization - Breakpoint0.00.00.20.30.1-0.10.00.20.10.1-0.20.1-0.10.0-0.10.3-0.5
Sum of active levers in priming session hrs 5-61.11.11.40.71.1-1.11.2-1.21.0-1.11.2-1.21.1-1.11.10.8-0.9
Progressive ratio0.20.20.5-0.4-0.60.6-0.40.3-0.60.5-0.40.4-0.50.4-0.5-0.70.0
Food seeking constrained by brief footshock1.62.03.80.81.5-1.51.4-1.91.1-1.51.7-1.71.5-1.51.50.6-1.0
Seeking ratio, punishment vs. effort1.21.52.20.81.3-1.31.1-1.51.1-1.31.4-1.41.3-1.11.30.9-0.5
Retroperitoneal fat weight0.00.10.2-0.4-0.30.3-0.0-0.3-0.1-0.10.2-0.20.1-0.10.1-0.4-0.4
Reaction time number correct0.10.10.40.50.3-0.30.3-0.10.4-0.30.2-0.20.3-0.30.30.6-0.3
Reaction time mean minus median1.62.13.5-0.9-1.51.5-1.41.9-1.21.5-1.71.7-1.61.4-1.6-0.81.1
Reaction time mean minus median AUC1.41.82.9-0.8-1.41.4-1.31.7-1.11.4-1.61.6-1.41.3-1.5-0.71.1
Reaction time num false alarms0.40.61.00.10.7-0.70.8-1.00.6-0.91.0-1.00.9-0.80.90.30.4
Reaction time num false alarms AUC0.30.50.9-0.20.5-0.50.6-1.00.5-0.80.9-0.90.8-0.70.90.10.4
Reaction time trials correct on left0.10.10.40.50.3-0.30.3-0.10.4-0.30.2-0.20.3-0.30.30.6-0.3
Reaction time trials on left0.10.10.30.40.2-0.20.2-0.00.4-0.20.1-0.10.2-0.30.20.6-0.2
Reaction time mean0.81.11.7-0.9-1.31.3-1.11.1-1.11.1-1.11.1-1.11.1-1.1-1.00.5
Reaction time mean AUC1.41.92.5-1.2-1.61.6-1.41.3-1.41.4-1.41.4-1.41.4-1.4-1.30.7
Median of all reaction times0.40.61.0-0.8-1.01.0-0.80.6-0.80.7-0.70.7-0.70.8-0.7-0.90.1
Reaction time omissions1.21.62.7-1.3-1.61.6-1.31.3-1.21.2-1.21.2-1.21.2-1.1-1.21.1
Reaction time false alarm rate0.20.30.8-0.40.4-0.40.5-0.90.2-0.60.8-0.80.7-0.50.7-0.20.6
Reaction time premature initiation rate2.93.95.7-2.4-2.12.1-2.01.7-2.01.9-1.81.8-1.92.0-1.9-2.11.8
Reaction time premature initiations1.42.02.6-1.6-1.51.5-1.41.3-1.41.4-1.31.3-1.41.4-1.4-1.31.4
Std. dev. reaction times1.31.92.6-0.9-1.51.5-1.41.6-1.21.4-1.51.5-1.41.3-1.5-1.00.9
Reaction time trials completed0.10.10.30.40.2-0.20.2-0.00.4-0.20.1-0.10.2-0.30.20.6-0.2
Reaction time trials AUC0.10.10.40.50.3-0.30.3-0.20.5-0.40.3-0.30.4-0.40.30.6-0.3
Run reversals in cocaine runway, females0.40.41.0-1.0-0.70.7-0.60.5-0.70.6-0.50.5-0.60.5-0.6-0.80.4
Run reversals in cocaine runway, males0.40.40.80.80.7-0.70.5-0.50.6-0.50.5-0.50.5-0.40.50.7-0.9
Latency to leave start box in cocaine runway0.10.10.30.10.1-0.10.3-0.40.2-0.40.4-0.40.4-0.50.4-0.1-0.4
Latency to leave start box in cocaine runway, F0.60.60.80.60.8-0.80.8-0.90.7-0.80.9-0.90.8-0.90.90.4-0.6
Latency to leave start box in cocaine runway, M0.60.51.2-0.7-1.11.1-0.70.7-0.80.7-0.70.7-0.70.5-0.7-0.80.2
Std. dev. time between licks in bursts0.00.00.10.20.2-0.20.10.00.2-0.10.0-0.00.1-0.30.10.2-0.2
Total sessions with >9 infusions0.00.00.0-0.1-0.10.1-0.20.2-0.10.2-0.20.2-0.20.2-0.2-0.1-0.1
Short access day 1 total inactive lever presses3.13.44.41.81.8-1.81.8-2.11.7-1.92.0-2.01.9-1.81.91.4-1.8
Short access day 10 total inactive lever presses0.20.20.6-0.8-0.30.3-0.30.2-0.40.3-0.20.2-0.30.2-0.3-0.50.7
Short access day 1 total infusions0.40.50.8-0.8-0.80.8-0.70.4-0.80.7-0.60.6-0.70.8-0.6-0.9-0.1
Short access day 10 total infusions0.40.50.6-0.5-0.80.8-0.70.6-0.70.7-0.70.7-0.70.7-0.7-0.8-0.2
Short access total infusions0.50.50.7-0.6-0.80.8-0.80.7-0.80.7-0.70.7-0.70.8-0.7-0.70.2
Short access day 1 locomotion1.71.83.1-1.8-1.41.4-1.41.1-1.51.3-1.21.2-1.31.4-1.3-1.60.6
Short access day 10 total locomotion0.80.92.2-1.5-1.01.0-0.90.5-1.20.9-0.70.7-0.90.9-0.9-1.4-0.4
Short access total locomotion3.73.95.2-2.3-2.12.1-2.01.8-2.12.0-1.91.9-2.02.0-2.0-2.20.8
One hour access (0.3 mA shock)0.00.00.4-0.0-0.10.1-0.10.1-0.20.2-0.20.2-0.2-0.0-0.2-0.2-0.6
Compulsive drug intake2.22.22.6-1.6-1.41.4-1.51.6-1.51.5-1.51.5-1.51.3-1.5-1.41.5
One hour access (shock baseline)0.60.72.80.90.7-0.70.7-0.80.7-0.70.7-0.70.7-0.80.70.6-1.7
Social response proportion2.02.12.81.31.7-1.71.4-1.61.4-1.41.5-1.51.4-1.41.41.3-1.4
Social responses2.73.43.71.91.9-1.91.8-1.81.9-1.91.9-1.91.9-1.81.91.9-1.3
Social time0.40.50.60.60.7-0.70.7-0.70.7-0.70.7-0.70.8-0.70.80.6-0.4
Soleus weight0.61.63.21.01.1-1.11.2-1.71.0-1.31.5-1.51.3-1.11.30.6-1.8
Bone: stiffness0.00.00.1-0.0-0.00.0-0.10.1-0.10.1-0.20.2-0.10.0-0.2-0.0-0.3
Tibialis anterior weight1.24.25.02.22.0-2.02.1-1.82.1-2.01.9-1.92.0-2.12.02.1-2.2
Time to tail flick, vehicle, before self-admin0.10.10.5-0.7-0.20.2-0.1-0.3-0.40.10.1-0.1-0.10.2-0.0-0.7-0.2
Time to tail flick, vehicle, after self-admin0.10.10.5-0.4-0.00.00.2-0.4-0.0-0.20.4-0.40.2-0.20.3-0.30.7
Time to tail flick, test, before self-admin0.80.81.6-0.3-0.80.8-0.81.3-0.60.9-1.11.1-1.01.0-1.0-0.30.7
Time to tail flick, test, after self-admin3.03.14.71.21.7-1.71.8-2.21.6-1.92.0-2.01.9-1.81.91.2-1.2
Delta time to tail flick, vehicle, before/after SA0.00.00.20.0-0.10.1-0.10.0-0.10.1-0.10.1-0.10.1-0.1-0.10.5
Delta time to tail flick, test, before/after SA2.62.43.70.91.5-1.51.5-1.91.4-1.71.8-1.81.7-1.61.71.0-1.0
Tibia length0.10.41.1-0.8-0.70.7-0.50.1-0.70.4-0.30.3-0.40.5-0.4-1.0-0.9
Ambulatory time before self-admin0.40.40.80.90.6-0.60.8-0.60.7-0.70.6-0.60.7-0.80.70.70.1
Ambulatory time after self-admin0.20.30.60.20.4-0.40.5-0.70.4-0.50.6-0.60.5-0.60.50.1-0.8
Bone: tissue strength0.10.10.50.70.1-0.10.10.40.30.1-0.30.3-0.1-0.1-0.10.6-0.4
Total heroin consumption0.10.21.50.40.0-0.00.3-0.20.2-0.20.2-0.20.2-0.20.20.2-1.2
Bone: trabecular number0.00.00.1-0.2-0.30.3-0.20.2-0.20.2-0.20.2-0.20.1-0.2-0.20.3
Bone: trabecular spacing1.01.21.51.21.2-1.21.1-1.11.1-1.11.1-1.11.1-1.01.01.0-1.2
Bone: trabecular thickness1.01.22.7-1.6-1.21.2-1.20.8-1.21.0-0.90.9-1.00.9-0.9-1.40.8
Bone: trabecular tissue density0.20.30.6-0.3-0.30.3-0.50.8-0.40.6-0.70.7-0.60.5-0.7-0.1-0.0
Water consumed over 24 hours1.61.93.11.71.6-1.61.4-0.91.5-1.31.1-1.11.2-1.51.21.8-0.9
Number of responses in last shaping day0.00.00.1-0.30.0-0.0-0.1-0.1-0.20.00.0-0.0-0.00.1-0.0-0.4-0.1