Hub : Genes

Cysltr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Cysltr2 0.21 0.13 4.3e-03 0.1 0.11 0.1 0.11 2.0e-03 1.2e-03 1.8e-03 1.6e-03
2 NAcc gene expression Cysltr2 0.03 0.02 2.2e-04 0.02 0.02 0.02 0.02 1.3e-04 5.8e-04 3.3e-04 3.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.10.20.2-0.50.4
Area under the delay curve0.30.40.5-0.70.6
BMI with tail0.00.00.00.2-0.1
BMI without tail0.10.40.40.7-0.6
Body weight0.10.60.8-0.90.7
Weight adjusted by age0.10.30.30.5-0.5
Bone surface0.30.60.6-0.80.7
Bone volume0.10.20.3-0.60.4
Breakpoint value in progressive ratio session1.12.02.61.2-1.6
Number of licking bursts0.00.10.1-0.30.2
Context. condit. distance diff. score0.70.80.91.0-0.9
Locomotion velocity, session 10.40.50.50.7-0.7
Locomotion distance, session 10.30.40.5-0.70.5
Locomotion velocity, session 20.30.30.4-0.60.6
Locomotion distance, session 20.71.01.3-1.10.9
Locomotion velocity, session 30.30.30.30.6-0.5
Locomotion distance, session 30.00.00.00.2-0.1
Stereotopy head waving bouts, day 30.60.70.70.8-0.8
Stereotopy head waving duration, day 30.50.60.70.7-0.8
Locomotion velocity, session 70.00.00.00.2-0.2
Locomotion distance, session 70.10.20.20.5-0.4
Stereotopy head waving bouts, day 70.20.30.3-0.60.4
Stereotopy head waving duration, day 70.00.00.0-0.10.1
Locomotion velocity, session 80.00.00.10.1-0.2
Locomotion distance, session 80.30.50.6-0.70.6
Degree of sensitization distance0.10.20.20.4-0.4
Degree of sensitization stereotypy0.20.30.3-0.60.5
Conditioned locomotion0.60.70.70.8-0.8
Cocaine response after cond. corrected2.74.04.32.1-1.9
Cocaine response after cond. not corrected0.91.31.41.2-1.1
Cocaine response before conditioning4.85.86.0-2.42.4
Saline control response0.91.31.4-1.21.0
Bone: connectivity density0.50.80.8-0.90.9
Bone: cortical apparent density1.11.71.71.3-1.3
Bone: cortical area0.20.30.3-0.50.5
Bone: cortical porosity2.93.13.2-1.81.7
Bone: cortical porosity2.32.52.6-1.61.6
Bone: cortical thickness0.30.50.5-0.70.6
Bone: cortical thickness0.30.40.40.6-0.6
Bone: cortical tissue density1.11.81.81.4-1.3
Condit. Reinf. active minus inactive responses1.11.21.5-1.21.0
Condit. Reinf. active-inactive response ratio0.40.40.40.7-0.6
Condit. Reinf. active responses3.44.34.9-2.22.0
Condit. Reinf. inactive responses6.17.98.5-2.92.7
Incentive salience index mean5.57.17.7-2.82.6
Condit. Reinf. lever presses8.512.813.4-3.73.5
Condit. Reinf. active minus inactive responses0.20.40.4-0.60.6
Condit. Reinf. active-inactive response ratio0.00.00.0-0.10.1
Condit. Reinf. active responses0.60.80.8-0.90.9
Condit. Reinf. inactive responses0.91.41.4-1.21.2
Condit. Reinf. lever presses3.14.64.8-2.12.2
Condit. Reinf. lever reinforcers received1.01.41.4-1.21.2
Conditioned reinforcement - actives0.10.50.70.8-0.6
Conditioned reinforcement - inactives1.95.15.2-2.22.3
Conditioned locomotion0.00.00.10.3-0.0
Patch foraging indifference point 0 sec3.710.311.1-3.33.1
Patch foraging indifference point AUC1.12.52.51.6-1.6
Delay disc. indifference point, 0s delay0.70.80.8-0.80.9
Delay disc. indifference point, 16s delay0.00.10.1-0.30.1
Delay disc. indifference point, 2s delay0.10.10.10.3-0.2
Delay disc. indifference point, 24s delay0.10.10.10.3-0.4
Delay disc. indifference point, 4s delay0.10.10.10.3-0.2
Delay disc. indifference point, 8s delay0.40.70.9-0.90.8
Indifference point function ln k1.23.53.6-1.91.9
Indifference point function log k1.23.53.6-1.91.9
Patch foraging total patch changes 0 sec3.39.710.4-3.23.0
Patch foraging total patch changes 12 sec1.62.12.4-1.61.3
Patch foraging total patch changes 18 sec0.10.20.3-0.50.3
Patch foraging total patch changes 24 sec0.72.42.9-1.71.4
Patch foraging total patch changes 6 sec0.81.41.6-1.31.1
Patch foraging time to switch 0 sec0.00.00.0-0.10.2
Patch foraging water rate 0 sec0.20.60.9-0.90.6
Patch foraging water rate 12 sec0.00.00.00.0-0.1
Patch foraging water rate 18 sec0.20.40.40.6-0.6
Patch foraging water rate 24 sec0.20.30.40.4-0.6
Patch foraging water rate 6 sec0.10.10.20.3-0.4
Seeking ratio, delayed vs. immediate footshock0.30.50.7-0.50.8
Distance traveled before self-admin0.20.50.50.6-0.7
Distance traveled after self-admin2.44.34.42.0-2.1
Extensor digitorum longus weight4.417.717.84.2-4.2
Bone: elastic displacement0.10.20.2-0.50.3
Bone: elastic work0.81.01.2-1.10.9
Bone: endosteal estimation0.10.10.1-0.30.4
Bone: endosteal perimeter0.00.10.1-0.20.4
Epididymis fat weight0.52.32.4-1.51.6
Delta time in closed arm before/after self-admin1.61.51.7-1.11.3
Delta time in open arm before/after self-admin0.10.10.10.2-0.3
Diff in mean of infusions in LGA sessions0.30.60.70.6-0.8
Delay discount exponential model param0.20.30.40.6-0.5
Extinction: sum of active levers before priming0.20.20.4-0.60.4
Active lever presses in extinction session 60.00.00.1-0.1-0.2
Bone: final force1.62.62.9-1.71.5
Bone: final moment1.82.93.2-1.81.6
Food consumed during 24 hour testing period0.50.91.0-0.91.0
Glucose0.91.41.41.1-1.2
Heart weight0.20.30.4-0.40.6
Delay discount hyperbolic model param0.10.20.20.4-0.4
Intermittent access intake day 1-15 change0.21.11.5-1.20.9
Intermittent access intake escalation0.42.02.5-1.61.2
Intermittent access intake escalation 20.10.20.3-0.50.4
Intermitt. access day 1 inactive lever presses0.00.10.1-0.40.3
Intermitt. access day 15 inactive lever presses0.31.41.6-1.31.1
Intermitt. access escalation Index0.00.00.10.1-0.3
Intermittent access day 1 total infusions0.20.60.8-0.90.7
Intermittent access day 15 total infusions1.22.83.3-1.81.5
Intermittent access terminal intake (last 3 days)0.50.81.0-1.00.8
Intermittent access total infusions1.31.51.7-1.31.1
Intermittent access day 1 locomotion1.52.82.9-1.71.6
Intermittent access day 15 total locomotion0.00.00.0-0.20.1
Intermittent access total locomotion0.91.11.2-1.11.0
Intermittent access standard deviation0.00.20.30.3-0.6
Left kidney weight1.29.910.1-3.13.2
Right kidney weight1.611.411.7-3.33.4
Cocaine induced anxiety0.61.71.9-1.21.4
Post-drug Anxiety2.12.42.6-1.51.6
Baseline Anxiety0.00.00.1-0.20.1
Tail length0.21.31.5-1.21.0
Length with tail0.41.72.1-1.51.1
Length without tail0.00.00.0-0.1-0.1
Times rat made contact with spout0.91.11.3-1.10.9
Lifetime Intake0.81.01.2-1.10.9
Liver weight, left0.50.91.1-1.10.9
Liver weight, right0.61.11.40.9-1.2
Locomotor activity0.61.01.1-1.01.0
Locomotor testing distance1.23.03.0-1.71.7
Locomotor testing rearing1.45.05.3-2.32.2
Locomotion in novel chamber0.71.01.1-1.10.9
Locomotion in novel chamber post-restriction0.20.70.90.8-0.9
Fecal boli incidents, locomotor time 10.00.10.2-0.40.1
Change in fecal boli incidents, locomotor task0.40.40.60.8-0.4
Time >=10cm from walls, locomotor time 11.62.02.2-1.31.5
Bouts of movement, locomotor time 11.11.51.51.2-1.2
Total resting periods, locomotor time 11.82.12.11.5-1.4
Rest time, locomotor task time 11.21.91.91.4-1.4
Distance moved, locomotor task time 10.41.11.1-1.11.0
Vertical activity count, locomotor time 10.00.00.0-0.10.0
Time >=10cm from walls, locomotor time 20.30.70.70.9-0.8
Bouts of movement, locomotor time 20.93.03.31.7-1.8
Total resting periods, locomotor time 20.72.73.01.5-1.7
Rest time, locomotor task time 20.81.41.61.1-1.3
Distance moved, locomotor task time 21.31.81.8-1.41.3
Vertical activity count, locomotor time 20.00.10.10.3-0.4
Light reinforcement 10.31.21.3-1.11.1
Light reinforcement 20.20.50.60.8-0.7
Bone: marrow area0.10.20.2-0.40.5
Bone: maximum diameter0.20.40.50.7-0.6
Bone: maximum force0.91.82.0-1.41.2
Bone: maximum moment1.22.22.5-1.61.4
Mean time between licks in bursts0.00.10.1-0.30.4
Mean num. licks in bursts0.00.00.1-0.30.2
Cd content in liver0.30.30.40.4-0.7
Co content in liver6.77.87.82.8-2.8
Cu content in liver0.40.50.60.8-0.7
Fe content in liver0.40.40.6-0.60.7
K content in liver1.01.01.1-0.91.1
Mg content in liver0.10.10.2-0.30.4
Mn content in liver0.40.40.40.7-0.6
Na content in liver2.22.52.6-1.61.6
Rb content in liver0.10.10.10.3-0.2
Se content in liver0.20.20.3-0.40.5
Sr content in liver0.60.50.50.7-0.7
Zn content in liver0.00.00.0-0.20.1
Bone: minimum diameter0.30.60.7-0.80.8
Time in familiar zone, hab. session 10.30.30.3-0.60.6
Time in novel zone, hab. session 15.46.06.02.5-2.4
Total zone transitions, hab. session 10.00.00.0-0.0-0.2
Total locomotion distance, hab. session 10.50.70.8-0.90.8
Locomotion velocity, hab. session 11.82.52.8-1.71.5
Time in familiar zone, hab. session 22.12.42.51.6-1.5
Time in novel zone, hab. session 20.20.20.2-0.50.4
Total zone transitions, hab. session 20.00.00.1-0.20.1
Total locomotion distance, hab. session 20.10.10.2-0.40.3
Locomotion velocity, hab. session 20.10.20.2-0.50.3
Novel to familiar place preference ratio1.11.41.6-1.31.1
Novelty place preference1.31.61.9-1.41.2
Time in novel zone, NPP test0.91.11.3-1.10.9
Total zone transitions, NPP test0.50.70.8-0.90.8
Total locomotion distance, NPP test1.52.12.3-1.51.4
Locomotion velocity, NPP test1.82.62.9-1.71.5
Intraocular pressure0.20.30.4-0.60.4
Delta distance traveled before/after self-admin3.53.83.82.0-1.9
Delta ambulatory time before/after self-admin1.32.32.41.5-1.5
Parametrial fat weight0.61.41.6-1.31.1
Pavlov. Cond. lever latency3.74.75.02.2-2.1
Pavlov. Cond. magazine entry latency0.60.80.8-0.90.9
Pavlov. Cond. change in total contacts2.12.32.6-1.61.4
Pavlov. Cond. index score3.54.44.7-2.22.0
Pavlov. Cond. latency score4.45.65.9-2.42.3
Pavlov. Cond. lever contacts4.75.76.0-2.42.3
Pavlov. Cond. magazine entry number0.40.50.60.8-0.7
Pavlov. Cond. intertrial magazine entries2.42.92.9-1.71.7
Pavlov. Cond. lever-magazine prob. diff.3.03.84.0-2.01.9
Pavlov. Cond. response bias1.01.21.3-1.11.1
Pavlov. Cond. lever latency2.02.73.01.6-1.7
Pavlov. Cond. magazine entry latency1.62.32.4-1.51.5
Pavlov. Cond. change in total contacts0.00.00.00.00.2
Pavlov. Cond. index score1.21.91.9-1.31.4
Pavlov. Cond. latency score1.52.42.5-1.51.6
Pavlov. Cond. lever contacts1.92.93.1-1.61.8
Pavlov. Cond. magazine entry number1.21.61.61.2-1.3
Pavlov. Cond. intertrial magazine entries1.02.22.3-1.51.5
Pavlov. Cond. lever-magazine prob. diff.1.01.51.6-1.21.3
Pavlov. Cond. response bias1.92.62.7-1.61.6
Time in closed arm before self-admin0.00.00.10.3-0.1
Time in closed arm after self-admin0.10.10.2-0.30.5
Time in open arm before self-admin0.20.20.20.5-0.4
Time in open arm after self-admin0.20.20.20.5-0.4
Bone: periosteal estimation0.00.10.1-0.30.4
Bone: periosteal perimeter0.00.00.0-0.00.1
Bone: post-yield work0.00.00.00.1-0.2
Progressive ratio test 1 active lever presses0.10.10.10.3-0.3
Progressive ratio test 1 breakpoint0.10.20.20.4-0.4
Progressive ratio test 1 inactive lever presses0.10.20.3-0.50.3
Progressive ratio test 2 active lever presses0.00.00.00.0-0.2
Progressive ratio test 2 breakpoint0.00.00.0-0.1-0.0
Progressive ratio test 2 inactive lever presses0.31.01.0-1.01.0
Incentive Sensitization - Responses0.00.10.1-0.30.3
Incentive Sensitization - Breakpoint0.10.20.3-0.50.4
Sum of active levers in priming session hrs 5-63.93.63.91.8-2.0
Progressive ratio0.72.22.51.3-1.6
Food seeking constrained by brief footshock13.516.917.24.1-4.1
Seeking ratio, punishment vs. effort0.30.60.80.9-0.6
Retroperitoneal fat weight0.31.31.4-1.21.1
Reaction time number correct1.44.85.12.3-2.1
Reaction time mean minus median0.10.91.1-1.00.8
Reaction time mean minus median AUC0.10.50.6-0.80.6
Reaction time num false alarms0.20.30.4-0.40.6
Reaction time num false alarms AUC0.10.30.5-0.40.7
Reaction time trials correct on left1.44.85.12.3-2.1
Reaction time trials on left1.34.64.92.2-2.1
Reaction time mean0.40.80.9-0.80.9
Reaction time mean AUC0.20.60.6-0.70.8
Median of all reaction times0.30.40.6-0.50.7
Reaction time omissions0.30.50.5-0.70.7
Reaction time false alarm rate1.41.92.1-1.31.4
Reaction time premature initiation rate0.50.81.01.0-0.8
Reaction time premature initiations1.44.34.92.2-1.9
Std. dev. reaction times0.10.40.4-0.70.5
Reaction time trials completed1.34.64.92.2-2.1
Reaction time trials AUC1.34.75.02.2-2.1
Run reversals in cocaine runway, females0.00.00.00.2-0.2
Run reversals in cocaine runway, males0.00.00.1-0.3-0.1
Latency to leave start box in cocaine runway0.91.21.21.1-1.1
Latency to leave start box in cocaine runway, F0.70.91.00.9-1.0
Latency to leave start box in cocaine runway, M0.60.60.70.9-0.7
Std. dev. time between licks in bursts2.85.35.7-2.22.4
Total sessions with >9 infusions0.30.40.4-0.60.6
Short access day 1 total inactive lever presses1.52.93.6-1.91.5
Short access day 10 total inactive lever presses0.00.10.1-0.30.1
Short access day 1 total infusions0.10.30.3-0.50.5
Short access day 10 total infusions0.20.40.5-0.70.5
Short access total infusions0.20.30.4-0.70.5
Short access day 1 locomotion0.40.60.7-0.70.9
Short access day 10 total locomotion0.20.91.1-0.91.1
Short access total locomotion1.01.51.7-1.21.3
One hour access (0.3 mA shock)0.50.60.7-0.90.7
Compulsive drug intake2.23.33.7-1.91.7
One hour access (shock baseline)0.10.30.30.5-0.5
Social response proportion2.73.43.92.0-1.7
Social responses0.10.20.30.5-0.2
Social time0.91.41.5-1.11.2
Soleus weight5.215.415.43.9-3.9
Bone: stiffness1.12.02.2-1.51.4
Tibialis anterior weight2.37.98.02.8-2.8
Time to tail flick, vehicle, before self-admin0.70.91.2-1.10.7
Time to tail flick, vehicle, after self-admin2.55.15.72.1-2.4
Time to tail flick, test, before self-admin2.12.42.4-1.61.5
Time to tail flick, test, after self-admin0.30.30.4-0.40.7
Delta time to tail flick, vehicle, before/after SA2.82.93.01.7-1.7
Delta time to tail flick, test, before/after SA0.70.81.11.0-0.8
Tibia length11.130.931.4-5.65.5
Ambulatory time before self-admin0.10.20.30.4-0.6
Ambulatory time after self-admin2.53.94.31.9-2.1
Bone: tissue strength0.90.91.0-0.91.0
Total heroin consumption1.11.21.70.9-1.3
Bone: trabecular number0.30.60.7-0.80.8
Bone: trabecular spacing0.50.80.90.9-0.8
Bone: trabecular thickness0.71.01.3-1.10.8
Bone: trabecular tissue density0.40.70.70.8-0.8
Water consumed over 24 hours0.00.00.0-0.10.0
Number of responses in last shaping day0.50.60.60.8-0.8