Hub : Genes

Cyp2d2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Cyp2d2 0.43 0.14 0.0e+00 0.27 0.26 0.27 0.27 4.0e-30 4.6e-29 1.0e-29 8.8e-30
2 Adipose gene expression Cyp2d2 0.09 0.08 2.0e-03 0.02 0.01 0.01 0.01 4.7e-03 7.8e-03 1.8e-02 2.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.30.51.0-1.0-0.0
Area under the delay curve0.30.50.6-0.60.8
BMI with tail0.41.21.51.2-1.0
BMI without tail0.10.50.70.9-0.5
Body weight0.83.54.11.7-2.0
Weight adjusted by age0.61.82.11.4-1.2
Bone surface0.51.12.1-0.2-1.5
Bone volume0.40.81.6-0.2-1.3
Breakpoint value in progressive ratio session0.20.30.4-0.60.6
Number of licking bursts0.00.10.2-0.5-0.1
Context. condit. distance diff. score5.66.88.12.8-2.4
Locomotion velocity, session 10.91.01.40.7-1.2
Locomotion distance, session 10.30.30.5-0.70.4
Locomotion velocity, session 20.70.91.50.6-1.2
Locomotion distance, session 22.94.15.4-2.31.7
Locomotion velocity, session 31.21.42.20.8-1.5
Locomotion distance, session 30.20.20.40.0-0.7
Stereotopy head waving bouts, day 30.50.50.80.5-0.9
Stereotopy head waving duration, day 32.93.64.11.8-2.0
Locomotion velocity, session 70.40.40.80.2-0.9
Locomotion distance, session 70.91.11.4-1.20.9
Stereotopy head waving bouts, day 76.67.69.32.4-3.1
Stereotopy head waving duration, day 75.36.67.82.3-2.8
Locomotion velocity, session 81.62.02.61.6-1.1
Locomotion distance, session 80.91.31.41.2-1.1
Degree of sensitization distance0.30.40.7-0.20.8
Degree of sensitization stereotypy5.56.17.42.2-2.7
Conditioned locomotion0.91.11.81.3-0.6
Cocaine response after cond. corrected0.10.20.30.5-0.2
Cocaine response after cond. not corrected0.30.50.60.6-0.8
Cocaine response before conditioning0.10.20.3-0.1-0.6
Saline control response1.01.41.71.3-1.1
Bone: connectivity density0.20.30.6-0.8-0.3
Bone: cortical apparent density0.61.01.1-1.10.9
Bone: cortical area1.11.82.80.9-1.7
Bone: cortical porosity0.30.30.30.50.6
Bone: cortical porosity0.70.81.51.2-0.3
Bone: cortical thickness0.20.30.5-0.70.2
Bone: cortical thickness0.10.20.3-0.50.3
Bone: cortical tissue density0.60.91.0-1.00.9
Condit. Reinf. active minus inactive responses0.60.71.2-1.1-0.4
Condit. Reinf. active-inactive response ratio0.70.81.50.2-1.2
Condit. Reinf. active responses1.31.62.9-1.70.6
Condit. Reinf. inactive responses2.43.13.3-1.81.7
Incentive salience index mean1.01.32.5-1.60.3
Condit. Reinf. lever presses1.42.13.0-1.71.1
Condit. Reinf. active minus inactive responses0.50.71.4-1.2-0.1
Condit. Reinf. active-inactive response ratio0.50.81.7-1.30.0
Condit. Reinf. active responses0.30.50.9-0.1-1.0
Condit. Reinf. inactive responses0.60.91.00.9-1.0
Condit. Reinf. lever presses0.50.81.5-1.20.2
Condit. Reinf. lever reinforcers received0.20.30.3-0.5-0.6
Conditioned reinforcement - actives0.00.20.30.2-0.5
Conditioned reinforcement - inactives0.61.71.9-1.41.2
Conditioned locomotion0.00.00.00.2-0.1
Patch foraging indifference point 0 sec0.30.81.4-1.20.5
Patch foraging indifference point AUC0.10.10.2-0.30.4
Delay disc. indifference point, 0s delay0.20.30.40.6-0.4
Delay disc. indifference point, 16s delay0.91.31.6-1.31.0
Delay disc. indifference point, 2s delay0.10.10.1-0.20.3
Delay disc. indifference point, 24s delay0.10.10.20.1-0.4
Delay disc. indifference point, 4s delay0.60.60.7-0.80.8
Delay disc. indifference point, 8s delay0.91.51.7-1.11.3
Indifference point function ln k0.51.42.10.9-1.4
Indifference point function log k0.51.42.10.9-1.4
Patch foraging total patch changes 0 sec0.30.91.4-1.20.6
Patch foraging total patch changes 12 sec0.10.20.4-0.60.1
Patch foraging total patch changes 18 sec0.40.81.2-1.10.7
Patch foraging total patch changes 24 sec0.00.10.2-0.50.2
Patch foraging total patch changes 6 sec0.30.50.6-0.80.6
Patch foraging time to switch 0 sec0.00.10.3-0.5-0.1
Patch foraging water rate 0 sec0.00.00.10.00.3
Patch foraging water rate 12 sec0.00.00.1-0.0-0.2
Patch foraging water rate 18 sec0.20.40.7-0.9-0.3
Patch foraging water rate 24 sec0.10.10.2-0.0-0.5
Patch foraging water rate 6 sec0.10.20.40.1-0.6
Seeking ratio, delayed vs. immediate footshock3.85.46.5-2.52.1
Distance traveled before self-admin1.94.15.0-1.82.2
Distance traveled after self-admin0.40.70.9-0.90.7
Extensor digitorum longus weight0.00.00.0-0.1-0.2
Bone: elastic displacement0.60.81.61.30.0
Bone: elastic work1.82.33.01.7-1.3
Bone: endosteal estimation2.35.77.02.1-2.6
Bone: endosteal perimeter3.38.19.62.6-3.1
Epididymis fat weight0.52.82.91.6-1.7
Delta time in closed arm before/after self-admin0.20.20.3-0.30.6
Delta time in open arm before/after self-admin1.21.42.00.8-1.4
Diff in mean of infusions in LGA sessions0.00.00.0-0.0-0.1
Delay discount exponential model param0.30.40.50.6-0.7
Extinction: sum of active levers before priming0.10.20.40.6-0.2
Active lever presses in extinction session 60.20.20.30.60.0
Bone: final force0.40.61.20.1-1.1
Bone: final moment0.50.91.70.2-1.3
Food consumed during 24 hour testing period0.10.30.50.2-0.7
Glucose0.40.60.7-0.70.8
Heart weight4.67.410.63.3-2.1
Delay discount hyperbolic model param0.30.40.50.5-0.7
Intermittent access intake day 1-15 change0.10.40.6-0.80.5
Intermittent access intake escalation0.10.30.5-0.70.3
Intermittent access intake escalation 20.30.50.6-0.80.6
Intermitt. access day 1 inactive lever presses0.11.82.3-1.21.5
Intermitt. access day 15 inactive lever presses0.73.53.9-1.82.0
Intermitt. access escalation Index0.10.30.4-0.60.6
Intermittent access day 1 total infusions0.00.00.1-0.2-0.2
Intermittent access day 15 total infusions0.00.10.2-0.50.0
Intermittent access terminal intake (last 3 days)0.00.00.0-0.2-0.2
Intermittent access total infusions0.00.00.0-0.2-0.2
Intermittent access day 1 locomotion0.40.70.7-0.80.8
Intermittent access day 15 total locomotion0.00.10.1-0.3-0.1
Intermittent access total locomotion0.20.20.3-0.50.4
Intermittent access standard deviation0.10.40.4-0.60.6
Left kidney weight3.830.530.65.5-5.5
Right kidney weight3.424.125.45.0-4.8
Cocaine induced anxiety0.10.20.3-0.50.1
Post-drug Anxiety0.10.10.2-0.5-0.0
Baseline Anxiety0.00.00.1-0.0-0.3
Tail length0.00.20.20.4-0.5
Length with tail0.52.33.01.3-1.7
Length without tail0.42.33.31.1-1.8
Times rat made contact with spout0.30.40.50.5-0.7
Lifetime Intake0.10.10.3-0.50.1
Liver weight, left3.45.86.72.2-2.6
Liver weight, right4.68.08.32.8-2.9
Locomotor activity2.03.14.02.0-1.5
Locomotor testing distance0.00.10.2-0.10.4
Locomotor testing rearing0.62.13.41.8-0.9
Locomotion in novel chamber2.12.83.01.6-1.7
Locomotion in novel chamber post-restriction0.10.20.3-0.40.5
Fecal boli incidents, locomotor time 10.00.10.1-0.20.3
Change in fecal boli incidents, locomotor task2.02.22.71.3-1.6
Time >=10cm from walls, locomotor time 10.00.00.00.1-0.2
Bouts of movement, locomotor time 10.00.00.0-0.1-0.1
Total resting periods, locomotor time 10.30.40.6-0.70.4
Rest time, locomotor task time 10.50.81.1-0.71.1
Distance moved, locomotor task time 10.72.12.51.3-1.6
Vertical activity count, locomotor time 10.00.20.40.2-0.6
Time >=10cm from walls, locomotor time 20.00.00.10.00.2
Bouts of movement, locomotor time 20.20.50.6-0.70.8
Total resting periods, locomotor time 20.20.70.8-0.80.9
Rest time, locomotor task time 20.30.60.7-0.70.8
Distance moved, locomotor task time 21.11.51.51.2-1.2
Vertical activity count, locomotor time 20.30.81.00.8-1.0
Light reinforcement 10.21.01.11.1-0.9
Light reinforcement 20.20.60.80.5-0.9
Bone: marrow area2.45.97.22.1-2.7
Bone: maximum diameter3.36.68.72.1-3.0
Bone: maximum force0.61.32.10.7-1.4
Bone: maximum moment0.91.82.80.8-1.7
Mean time between licks in bursts0.10.40.7-0.40.8
Mean num. licks in bursts0.41.01.51.2-0.7
Cd content in liver1.11.21.51.2-0.9
Co content in liver0.00.00.1-0.10.3
Cu content in liver2.63.04.4-2.11.3
Fe content in liver0.50.60.70.8-0.7
K content in liver0.30.30.6-0.80.1
Mg content in liver1.31.52.6-1.60.6
Mn content in liver0.50.61.00.5-1.0
Na content in liver1.41.61.7-1.21.3
Rb content in liver0.00.00.1-0.10.3
Se content in liver0.20.30.6-0.2-0.7
Sr content in liver1.81.62.1-1.01.4
Zn content in liver0.50.61.10.0-1.1
Bone: minimum diameter1.02.02.91.0-1.7
Time in familiar zone, hab. session 10.40.40.70.4-0.8
Time in novel zone, hab. session 10.91.01.71.3-0.5
Total zone transitions, hab. session 10.70.91.1-0.91.1
Total locomotion distance, hab. session 10.00.00.00.2-0.1
Locomotion velocity, hab. session 10.10.10.2-0.40.2
Time in familiar zone, hab. session 21.21.41.71.0-1.3
Time in novel zone, hab. session 20.20.30.5-0.20.7
Total zone transitions, hab. session 20.60.80.9-0.80.9
Total locomotion distance, hab. session 20.40.50.6-0.70.8
Locomotion velocity, hab. session 20.60.80.9-0.90.9
Novel to familiar place preference ratio3.84.95.82.4-2.0
Novelty place preference5.06.47.82.8-2.2
Time in novel zone, NPP test6.17.49.23.0-2.4
Total zone transitions, NPP test0.71.01.2-0.91.1
Total locomotion distance, NPP test0.50.70.8-0.80.9
Locomotion velocity, NPP test0.91.21.3-1.11.1
Intraocular pressure0.71.22.10.5-1.4
Delta distance traveled before/after self-admin3.94.35.81.7-2.4
Delta ambulatory time before/after self-admin3.05.26.91.9-2.6
Parametrial fat weight0.20.60.60.7-0.8
Pavlov. Cond. lever latency1.31.71.81.3-1.3
Pavlov. Cond. magazine entry latency1.82.33.0-1.31.7
Pavlov. Cond. change in total contacts2.93.23.2-1.81.8
Pavlov. Cond. index score2.32.93.5-1.51.9
Pavlov. Cond. latency score1.82.32.8-1.31.7
Pavlov. Cond. lever contacts3.34.04.3-1.92.1
Pavlov. Cond. magazine entry number2.33.03.41.6-1.8
Pavlov. Cond. intertrial magazine entries0.70.81.2-1.10.7
Pavlov. Cond. lever-magazine prob. diff.2.53.13.6-1.61.9
Pavlov. Cond. response bias3.13.94.1-1.92.0
Pavlov. Cond. lever latency1.21.63.01.7-0.5
Pavlov. Cond. magazine entry latency5.37.510.6-3.32.1
Pavlov. Cond. change in total contacts1.43.35.1-2.31.2
Pavlov. Cond. index score2.94.67.4-2.71.3
Pavlov. Cond. latency score3.55.78.6-2.91.6
Pavlov. Cond. lever contacts1.31.93.4-1.80.6
Pavlov. Cond. magazine entry number4.55.98.12.8-1.9
Pavlov. Cond. intertrial magazine entries0.40.81.41.2-0.4
Pavlov. Cond. lever-magazine prob. diff.3.04.67.4-2.71.4
Pavlov. Cond. response bias2.23.05.1-2.31.0
Time in closed arm before self-admin1.22.12.6-1.61.3
Time in closed arm after self-admin0.00.00.10.30.1
Time in open arm before self-admin0.00.00.00.20.2
Time in open arm after self-admin0.80.81.30.6-1.1
Bone: periosteal estimation2.45.78.11.8-2.8
Bone: periosteal perimeter4.48.710.72.6-3.3
Bone: post-yield work0.00.00.1-0.30.1
Progressive ratio test 1 active lever presses0.40.70.8-0.80.9
Progressive ratio test 1 breakpoint0.40.70.7-0.80.8
Progressive ratio test 1 inactive lever presses1.43.63.9-1.82.0
Progressive ratio test 2 active lever presses0.60.91.2-1.10.8
Progressive ratio test 2 breakpoint0.60.81.1-1.00.7
Progressive ratio test 2 inactive lever presses1.03.23.7-1.91.6
Incentive Sensitization - Responses0.10.40.6-0.80.4
Incentive Sensitization - Breakpoint0.20.40.6-0.80.5
Sum of active levers in priming session hrs 5-60.10.00.10.30.1
Progressive ratio0.30.81.0-0.81.0
Food seeking constrained by brief footshock0.60.71.20.5-1.1
Seeking ratio, punishment vs. effort0.20.50.80.6-0.9
Retroperitoneal fat weight1.77.78.42.9-2.6
Reaction time number correct0.00.00.00.20.0
Reaction time mean minus median0.11.01.91.4-0.1
Reaction time mean minus median AUC0.21.32.51.6-0.4
Reaction time num false alarms0.91.51.71.3-1.1
Reaction time num false alarms AUC0.71.51.81.3-1.1
Reaction time trials correct on left0.00.00.00.20.0
Reaction time trials on left0.00.00.00.20.0
Reaction time mean0.30.61.2-0.01.1
Reaction time mean AUC0.20.61.2-0.01.1
Median of all reaction times0.61.01.8-0.51.3
Reaction time omissions0.20.30.60.80.0
Reaction time false alarm rate0.60.80.91.0-0.8
Reaction time premature initiation rate0.91.42.0-1.40.8
Reaction time premature initiations0.30.91.2-1.10.8
Std. dev. reaction times0.30.91.81.4-0.2
Reaction time trials completed0.00.00.00.20.0
Reaction time trials AUC0.00.00.00.10.0
Run reversals in cocaine runway, females0.20.20.30.5-0.4
Run reversals in cocaine runway, males2.83.03.51.6-1.9
Latency to leave start box in cocaine runway0.00.00.00.00.1
Latency to leave start box in cocaine runway, F0.00.10.1-0.20.3
Latency to leave start box in cocaine runway, M0.10.10.10.3-0.2
Std. dev. time between licks in bursts1.22.22.8-1.71.3
Total sessions with >9 infusions0.00.00.10.3-0.0
Short access day 1 total inactive lever presses0.00.00.0-0.10.2
Short access day 10 total inactive lever presses0.10.60.70.8-0.7
Short access day 1 total infusions0.00.00.00.2-0.0
Short access day 10 total infusions0.00.00.0-0.20.2
Short access total infusions0.10.20.2-0.40.4
Short access day 1 locomotion0.00.10.2-0.10.4
Short access day 10 total locomotion0.52.12.8-1.21.7
Short access total locomotion0.40.60.9-0.51.0
One hour access (0.3 mA shock)0.50.61.0-1.00.4
Compulsive drug intake0.20.30.5-0.70.4
One hour access (shock baseline)0.10.10.3-0.50.1
Social response proportion0.00.00.0-0.1-0.1
Social responses0.60.81.00.7-1.0
Social time1.01.51.7-1.31.2
Soleus weight0.10.40.4-0.60.6
Bone: stiffness0.20.40.70.4-0.9
Tibialis anterior weight0.72.32.9-1.31.7
Time to tail flick, vehicle, before self-admin0.20.30.50.7-0.2
Time to tail flick, vehicle, after self-admin0.40.80.80.9-0.9
Time to tail flick, test, before self-admin0.81.01.10.9-1.0
Time to tail flick, test, after self-admin0.10.10.2-0.0-0.4
Delta time to tail flick, vehicle, before/after SA0.00.10.10.0-0.3
Delta time to tail flick, test, before/after SA0.60.71.1-1.00.6
Tibia length0.82.13.90.6-2.0
Ambulatory time before self-admin0.72.02.7-1.21.6
Ambulatory time after self-admin0.10.20.3-0.50.2
Bone: tissue strength0.40.40.80.3-0.9
Total heroin consumption0.00.00.1-0.00.3
Bone: trabecular number0.30.61.2-0.0-1.1
Bone: trabecular spacing0.00.00.10.30.0
Bone: trabecular thickness0.20.20.5-0.7-0.1
Bone: trabecular tissue density2.64.57.4-1.22.7
Water consumed over 24 hours0.20.50.70.5-0.8
Number of responses in last shaping day5.47.08.0-2.42.8