Hub : Genes

Cyp2c6v1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Cyp2c6v1	0.38	0.08	0.0e+00	0.41	0.4	0.4	0.41	4.7e-49	8.5e-47	7.2e-47	3.6e-48
2	Liver	gene expression	Cyp2c6v1	0.53	0.04	0.0e+00	0.42	0.52	0.51	0.51	1.7e-50	2.3e-66	7.9e-66	9.0e-66
3	Liver	intron excision ratio	chr1_247913572_247915175	0.61	0.03	0.0e+00	0.4	0.48	0.48	0.48	7.8e-47	1.4e-59	1.3e-59	2.5e-59
4	Liver	isoform ratio	NM_001013904.2	0.21	0.06	1.0e-15	0.14	0.15	0.15	0.13	4.0e-15	3.9e-16	3.8e-16	1.7e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.2	0.4	1.0	-1.0	0.3	0.2	0.8
Area under the delay curve	1.5	2.3	3.7	1.4	-1.8	1.9	0.5
BMI with tail	0.4	1.4	4.0	-1.0	0.0	0.7	2.0
BMI without tail	0.1	0.3	1.1	-0.2	-0.1	0.3	1.0
Body weight	0.3	1.3	2.0	-1.2	1.3	-1.4	0.1
Weight adjusted by age	0.2	0.6	1.6	-0.5	-0.3	0.7	1.3
Bone surface	0.5	1.0	2.4	-1.5	0.8	-0.3	0.9
Bone volume	0.7	1.3	3.2	-1.8	1.2	-0.6	0.6
Breakpoint value in progressive ratio session	0.2	0.4	1.0	1.0	-0.6	0.3	-0.2
Number of licking bursts	1.1	3.4	5.0	2.0	-2.2	2.1	0.4
Context. condit. distance diff. score	0.2	0.2	0.4	-0.6	0.5	-0.5	0.2
Locomotion velocity, session 1	3.9	4.4	6.4	2.4	-2.5	2.3	-0.3
Locomotion distance, session 1	1.4	1.8	2.7	1.6	-1.5	1.2	-0.9
Locomotion velocity, session 2	1.3	1.6	2.1	1.4	-1.5	1.4	-0.2
Locomotion distance, session 2	0.6	0.8	1.3	0.9	-1.1	1.2	0.1
Locomotion velocity, session 3	0.3	0.4	0.8	-0.0	0.5	-0.7	-0.9
Locomotion distance, session 3	1.6	1.8	3.5	-0.4	1.4	-1.9	-1.3
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	0.5	-0.6	0.3	-0.6
Stereotopy head waving duration, day 3	0.6	0.8	1.4	0.8	-1.2	1.1	0.0
Locomotion velocity, session 7	0.9	1.0	1.4	-1.1	1.2	-1.1	-0.4
Locomotion distance, session 7	1.3	1.7	2.5	-1.5	1.6	-1.4	0.0
Stereotopy head waving bouts, day 7	1.8	2.1	3.5	1.9	-1.7	1.1	-0.6
Stereotopy head waving duration, day 7	0.8	1.0	1.7	1.3	-1.2	0.8	-0.4
Locomotion velocity, session 8	0.1	0.1	0.5	0.1	0.1	0.0	-0.7
Locomotion distance, session 8	0.1	0.2	0.4	0.2	-0.5	0.6	0.1
Degree of sensitization distance	0.7	0.8	1.4	0.1	-0.8	1.2	1.0
Degree of sensitization stereotypy	1.7	1.9	3.8	1.9	-1.6	1.0	-0.6
Conditioned locomotion	0.9	1.0	2.0	-1.4	1.2	-0.8	0.3
Cocaine response after cond. corrected	0.1	0.1	0.3	0.2	-0.4	0.5	0.3
Cocaine response after cond. not corrected	0.1	0.2	0.3	0.5	-0.4	0.2	-0.4
Cocaine response before conditioning	0.7	0.8	1.7	1.1	-0.4	-0.2	-1.3
Saline control response	1.4	1.9	3.2	1.8	-1.1	0.6	-1.7
Bone: connectivity density	0.9	1.5	3.5	-1.5	0.5	0.4	1.9
Bone: cortical apparent density	1.5	2.3	3.4	1.6	-1.8	1.7	0.5
Bone: cortical area	2.4	3.8	5.6	-1.7	2.1	-2.4	-1.5
Bone: cortical porosity	1.5	1.6	2.5	0.5	-1.4	1.6	1.3
Bone: cortical porosity	0.5	0.5	0.8	0.1	-0.7	0.8	0.9
Bone: cortical thickness	1.5	2.5	7.9	0.6	0.4	-1.3	-2.8
Bone: cortical thickness	2.0	2.5	3.8	2.0	-1.4	0.5	-1.9
Bone: cortical tissue density	1.7	2.7	3.9	1.7	-2.0	1.9	0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.1	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	0.1	0.0	0.1
Condit. Reinf. active responses	0.0	0.0	0.1	0.3	-0.0	-0.0	-0.2
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.4	-0.4	0.2	-0.1
Incentive salience index mean	0.2	0.2	0.6	0.4	0.1	-0.2	-0.8
Condit. Reinf. lever presses	0.2	0.4	0.9	0.7	-0.2	0.1	-1.0
Condit. Reinf. active minus inactive responses	1.0	1.6	3.1	-1.8	1.4	-0.8	0.9
Condit. Reinf. active-inactive response ratio	0.5	0.8	1.4	-1.2	0.6	-0.1	1.2
Condit. Reinf. active responses	1.6	2.2	3.3	-1.5	1.8	-1.8	-0.6
Condit. Reinf. inactive responses	1.8	2.7	5.4	-0.1	1.3	-2.0	-2.3
Condit. Reinf. lever presses	0.5	0.7	2.0	0.2	0.4	-0.8	-1.4
Condit. Reinf. lever reinforcers received	1.0	1.4	2.0	-1.0	1.4	-1.4	-0.8
Conditioned reinforcement - actives	0.0	0.2	0.5	0.7	-0.3	-0.1	-0.4
Conditioned reinforcement - inactives	0.2	0.6	1.2	1.1	-0.9	0.5	0.2
Conditioned locomotion	0.1	0.2	0.4	0.5	-0.1	-0.3	-0.7
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.3	0.3	-0.7	-0.5
Patch foraging indifference point AUC	1.7	4.0	8.0	2.8	-2.0	1.2	-1.6
Delay disc. indifference point, 0s delay	0.8	0.9	1.9	-0.6	-0.4	1.1	1.4
Delay disc. indifference point, 16s delay	0.8	1.1	1.5	1.2	-1.2	1.1	0.3
Delay disc. indifference point, 2s delay	1.6	1.8	3.1	0.4	-1.3	1.8	1.6
Delay disc. indifference point, 24s delay	1.8	2.8	4.9	2.2	-1.9	1.4	-0.8
Delay disc. indifference point, 4s delay	1.7	1.8	2.8	0.9	-1.5	1.7	1.1
Delay disc. indifference point, 8s delay	2.2	3.7	5.3	2.2	-2.3	2.2	-0.4
Indifference point function ln k	1.1	3.3	6.4	-2.5	1.9	-1.1	1.4
Indifference point function log k	1.1	3.3	6.4	-2.5	1.9	-1.1	1.4
Patch foraging total patch changes 0 sec	0.1	0.3	0.7	0.2	0.5	-0.9	-0.5
Patch foraging total patch changes 12 sec	2.5	3.3	6.6	2.6	-1.8	1.1	-1.5
Patch foraging total patch changes 18 sec	0.7	1.7	3.1	1.8	-1.4	1.1	-0.8
Patch foraging total patch changes 24 sec	0.1	0.4	0.7	0.8	-0.2	-0.3	-0.8
Patch foraging total patch changes 6 sec	1.8	3.1	7.0	2.6	-1.5	0.6	-1.6
Patch foraging time to switch 0 sec	0.3	1.3	1.9	1.1	-1.4	1.4	0.2
Patch foraging water rate 0 sec	0.3	1.0	1.5	-1.2	1.2	-1.1	0.1
Patch foraging water rate 12 sec	0.1	0.6	1.0	-0.7	0.9	-1.0	-0.2
Patch foraging water rate 18 sec	0.2	0.5	0.8	-0.7	0.8	-0.9	-0.4
Patch foraging water rate 24 sec	0.2	0.3	0.4	-0.6	0.6	-0.5	0.4
Patch foraging water rate 6 sec	0.0	0.0	0.0	-0.2	0.1	-0.0	-0.0
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.1	-0.2	0.8	-1.1	-0.0
Distance traveled before self-admin	0.1	0.2	0.5	-0.0	-0.2	0.5	0.7
Distance traveled after self-admin	0.1	0.3	0.6	-0.7	0.3	0.1	0.6
Extensor digitorum longus weight	0.1	0.5	1.4	-0.6	0.4	-0.3	1.2
Bone: elastic displacement	0.4	0.6	1.1	-0.2	-0.6	1.0	0.9
Bone: elastic work	0.1	0.1	0.2	-0.4	-0.2	0.4	-0.0
Bone: endosteal estimation	1.6	3.8	7.8	-2.8	2.0	-1.0	1.6
Bone: endosteal perimeter	1.6	3.8	8.0	-2.8	2.1	-1.3	1.1
Epididymis fat weight	0.6	2.9	5.8	-2.4	1.7	-0.9	1.5
Delta time in closed arm before/after self-admin	0.4	0.4	0.8	-0.1	0.4	-0.8	-0.9
Delta time in open arm before/after self-admin	0.3	0.4	0.9	-0.4	-0.1	0.6	1.0
Diff in mean of infusions in LGA sessions	0.1	0.2	0.4	-0.7	0.5	-0.3	-0.1
Delay discount exponential model param	1.7	2.3	3.5	-1.5	1.8	-1.9	-0.5
Extinction: sum of active levers before priming	0.1	0.2	0.5	-0.1	0.5	-0.7	-0.4
Active lever presses in extinction session 6	1.4	1.4	3.1	-0.1	-1.0	1.7	1.3
Bone: final force	0.5	0.8	1.3	-0.6	0.8	-1.1	-0.8
Bone: final moment	0.6	1.0	1.6	-0.9	1.0	-1.3	-0.8
Food consumed during 24 hour testing period	0.4	0.7	1.7	1.0	-0.3	-0.4	-1.3
Glucose	0.6	0.9	1.8	-0.6	1.1	-1.3	-0.6
Heart weight	1.3	2.1	3.7	-1.2	1.8	-1.9	-0.3
Delay discount hyperbolic model param	1.5	2.0	3.2	-1.2	1.6	-1.8	-0.7
Intermittent access intake day 1-15 change	0.1	0.8	1.6	-1.3	1.0	-0.7	0.2
Intermittent access intake escalation	0.2	1.2	2.3	-1.5	1.2	-0.8	0.5
Intermittent access intake escalation 2	0.5	0.8	1.7	-1.3	0.9	-0.4	0.6
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.5	-0.2	-0.2	0.7	0.2
Intermitt. access day 15 inactive lever presses	0.1	0.5	0.7	-0.7	0.8	-0.8	-0.4
Intermitt. access escalation Index	0.2	0.5	0.7	-0.8	0.8	-0.6	-0.5
Intermittent access day 1 total infusions	0.1	0.2	0.3	0.4	-0.4	0.5	0.5
Intermittent access day 15 total infusions	0.6	1.5	2.3	-1.3	1.5	-1.5	0.1
Intermittent access terminal intake (last 3 days)	0.2	0.4	0.6	-0.6	0.8	-0.8	0.1
Intermittent access total infusions	0.1	0.2	0.3	-0.3	0.5	-0.5	-0.0
Intermittent access day 1 locomotion	0.3	0.5	0.8	-0.8	0.7	-0.5	0.9
Intermittent access day 15 total locomotion	0.1	0.6	0.7	0.9	-0.8	0.7	0.6
Intermittent access total locomotion	0.4	0.5	0.7	0.4	-0.6	0.8	0.8
Intermittent access standard deviation	0.1	0.7	0.8	-0.7	0.9	-0.9	-0.9
Left kidney weight	0.1	0.9	1.9	0.5	0.4	-1.1	-1.4
Right kidney weight	0.1	0.7	1.3	0.7	0.3	-1.2	-1.0
Cocaine induced anxiety	0.3	0.7	1.7	-1.0	0.4	0.0	1.3
Post-drug Anxiety	1.0	1.1	1.9	-1.4	1.0	-0.7	1.0
Baseline Anxiety	0.6	1.0	1.8	-0.6	1.1	-1.3	-0.7
Tail length	0.2	1.3	2.6	-0.4	1.1	-1.6	-1.1
Length with tail	0.5	2.1	3.9	0.0	1.1	-2.0	-1.8
Length without tail	0.2	0.8	1.5	0.0	0.7	-1.1	-1.2
Times rat made contact with spout	0.3	0.3	0.4	0.6	-0.6	0.6	-0.4
Lifetime Intake	0.1	0.1	0.1	-0.3	0.4	-0.2	0.2
Liver weight, left	0.1	0.2	0.3	-0.3	0.5	-0.5	-0.3
Liver weight, right	0.4	0.7	0.9	-1.0	1.0	-0.8	0.5
Locomotor activity	0.2	0.3	1.0	0.1	-0.0	-0.3	-1.0
Locomotor testing distance	0.1	0.2	0.5	0.2	-0.1	-0.4	-0.7
Locomotor testing rearing	0.1	0.4	0.7	-0.8	0.5	-0.4	0.6
Locomotion in novel chamber	1.7	2.2	5.8	-1.6	0.6	0.1	2.4
Locomotion in novel chamber post-restriction	0.1	0.3	1.1	0.4	-0.1	-0.2	-1.0
Fecal boli incidents, locomotor time 1	0.1	0.2	0.4	0.2	-0.5	0.6	0.0
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	-0.1	0.5	-0.7	-0.8
Time >=10cm from walls, locomotor time 1	2.7	3.4	8.6	0.4	0.9	-2.0	-2.9
Bouts of movement, locomotor time 1	1.5	2.0	2.7	1.4	-1.6	1.6	0.7
Total resting periods, locomotor time 1	2.3	2.6	3.8	1.9	-1.9	1.7	0.2
Rest time, locomotor task time 1	1.3	2.2	3.7	1.3	-1.7	1.9	0.7
Distance moved, locomotor task time 1	1.1	3.0	6.1	-1.1	1.9	-2.5	-1.0
Vertical activity count, locomotor time 1	0.2	1.6	3.5	-0.7	1.4	-1.9	-0.6
Time >=10cm from walls, locomotor time 2	0.2	0.6	1.8	0.4	0.1	-0.7	-1.3
Bouts of movement, locomotor time 2	1.6	5.4	8.1	2.6	-2.8	2.6	0.1
Total resting periods, locomotor time 2	1.5	5.9	8.8	2.8	-3.0	2.6	-0.1
Rest time, locomotor task time 2	1.5	2.6	3.8	1.9	-1.9	1.7	0.1
Distance moved, locomotor task time 2	2.1	2.8	4.4	-1.6	2.0	-2.1	-0.3
Vertical activity count, locomotor time 2	0.2	0.5	0.8	-0.6	0.8	-0.9	-0.2
Light reinforcement 1	0.1	0.5	0.7	0.5	-0.8	0.8	0.8
Light reinforcement 2	1.4	3.2	4.9	1.9	-2.2	2.1	-0.1
Bone: marrow area	1.5	3.8	7.7	-2.8	1.9	-1.0	1.6
Bone: maximum diameter	2.5	5.0	9.4	-3.1	2.6	-1.9	0.4
Bone: maximum force	0.2	0.4	0.7	-0.8	0.6	-0.7	-0.2
Bone: maximum moment	0.3	0.6	1.1	-1.0	0.8	-0.8	-0.2
Mean time between licks in bursts	0.1	0.5	0.9	-0.6	0.8	-1.0	0.1
Mean num. licks in bursts	0.9	2.5	3.8	-1.8	2.0	-1.7	-0.4
Cd content in liver	0.5	0.6	1.3	1.1	-0.8	0.4	-0.5
Co content in liver	1.5	1.8	3.2	-0.6	1.4	-1.8	-1.3
Cu content in liver	3.9	4.6	7.3	2.7	-2.6	1.9	-0.7
Fe content in liver	1.5	1.8	3.2	1.8	-1.6	1.2	-0.5
K content in liver	1.3	1.3	2.1	1.3	-1.4	1.2	-0.2
Mg content in liver	1.1	1.2	2.0	1.2	-1.4	1.2	0.2
Mn content in liver	7.0	7.8	11.7	2.9	-3.4	3.0	1.3
Na content in liver	1.5	1.7	2.7	1.6	-1.6	1.1	-0.4
Rb content in liver	0.2	0.2	0.7	0.2	-0.1	-0.1	-0.9
Se content in liver	13.1	15.5	28.0	5.3	-4.6	3.3	-1.3
Sr content in liver	0.4	0.3	0.5	0.7	-0.5	0.2	-0.6
Zn content in liver	1.5	1.7	2.8	1.7	-1.7	1.0	-0.6
Bone: minimum diameter	4.9	9.4	15.9	-4.0	3.6	-2.8	0.7
Time in familiar zone, hab. session 1	0.4	0.4	1.1	-0.6	0.1	0.2	1.1
Time in novel zone, hab. session 1	0.1	0.2	0.3	0.5	-0.5	0.4	-0.1
Total zone transitions, hab. session 1	0.1	0.2	0.4	0.2	-0.5	0.6	0.2
Total locomotion distance, hab. session 1	1.2	1.6	2.6	1.6	-1.4	1.0	-1.1
Locomotion velocity, hab. session 1	1.8	2.5	4.0	2.0	-1.5	1.0	-1.7
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.5	0.3	0.1	0.3
Time in novel zone, hab. session 2	0.1	0.2	0.4	0.7	-0.4	-0.0	-0.2
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.3	-0.3	0.4	-0.0
Total locomotion distance, hab. session 2	0.3	0.4	0.7	0.9	-0.6	0.5	-0.6
Locomotion velocity, hab. session 2	0.5	0.7	1.1	1.0	-0.8	0.8	-0.6
Novel to familiar place preference ratio	1.5	1.9	3.1	0.6	-1.4	1.8	1.5
Novelty place preference	1.5	1.9	3.1	0.5	-1.3	1.8	1.6
Time in novel zone, NPP test	1.5	1.8	2.9	0.4	-1.2	1.7	1.7
Total zone transitions, NPP test	0.3	0.4	1.5	0.4	0.0	-0.3	-1.2
Total locomotion distance, NPP test	1.8	2.5	4.4	1.9	-1.2	0.5	-2.1
Locomotion velocity, NPP test	1.6	2.3	5.0	1.8	-1.0	0.3	-2.2
Intraocular pressure	0.8	1.3	3.6	0.1	-0.8	1.0	1.9
Delta distance traveled before/after self-admin	0.8	0.9	1.9	-1.4	0.9	-0.5	0.6
Delta ambulatory time before/after self-admin	0.9	1.5	3.1	-1.8	1.3	-0.9	0.5
Parametrial fat weight	0.5	1.2	2.7	0.3	0.6	-1.3	-1.7
Pavlov. Cond. lever latency	0.2	0.3	0.8	-0.6	0.1	0.3	0.9
Pavlov. Cond. magazine entry latency	1.0	1.3	3.8	0.8	0.2	-0.9	-2.0
Pavlov. Cond. change in total contacts	0.4	0.4	0.8	0.3	0.3	-0.8	-0.9
Pavlov. Cond. index score	0.7	0.9	2.4	1.1	-0.3	-0.4	-1.6
Pavlov. Cond. latency score	0.7	0.9	2.4	0.9	-0.1	-0.5	-1.5
Pavlov. Cond. lever contacts	0.3	0.4	0.8	0.8	-0.2	-0.2	-0.9
Pavlov. Cond. magazine entry number	0.6	0.7	1.8	-0.2	-0.5	0.9	1.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.6	-0.5	0.4	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	2.0	1.0	-0.3	-0.3	-1.4
Pavlov. Cond. response bias	0.5	0.6	1.7	0.5	0.2	-0.8	-1.3
Pavlov. Cond. lever latency	0.8	1.2	3.5	-0.7	-0.1	0.7	1.9
Pavlov. Cond. magazine entry latency	0.5	0.7	1.9	0.5	0.2	-0.7	-1.4
Pavlov. Cond. change in total contacts	0.3	0.8	2.0	0.0	0.6	-0.9	-1.4
Pavlov. Cond. index score	0.8	1.3	3.9	0.7	0.2	-0.9	-2.0
Pavlov. Cond. latency score	0.7	1.2	3.5	0.7	0.2	-0.8	-1.9
Pavlov. Cond. lever contacts	0.8	1.2	3.5	0.7	0.2	-0.8	-1.9
Pavlov. Cond. magazine entry number	1.3	1.7	4.9	-1.2	0.1	0.7	2.2
Pavlov. Cond. intertrial magazine entries	0.4	0.8	2.4	-0.8	0.1	0.5	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.3	3.9	0.7	0.2	-0.8	-2.0
Pavlov. Cond. response bias	1.0	1.4	4.3	0.7	0.2	-0.9	-2.1
Time in closed arm before self-admin	0.1	0.3	0.7	0.2	-0.5	0.8	0.3
Time in closed arm after self-admin	0.1	0.1	0.2	-0.0	-0.1	0.2	-0.4
Time in open arm before self-admin	0.4	0.5	1.6	-0.3	-0.2	0.4	1.3
Time in open arm after self-admin	0.4	0.4	1.2	0.1	-0.4	0.6	1.1
Bone: periosteal estimation	1.4	3.4	6.3	-2.5	2.1	-1.6	0.4
Bone: periosteal perimeter	1.8	3.5	6.4	-2.5	2.2	-1.7	0.1
Bone: post-yield work	0.4	0.7	1.5	-0.9	0.6	-0.4	1.2
Progressive ratio test 1 active lever presses	0.2	0.3	0.7	0.4	-0.4	0.6	0.8
Progressive ratio test 1 breakpoint	0.2	0.3	0.6	0.4	-0.5	0.6	0.8
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.9	-0.2	-0.0	0.4	1.0
Progressive ratio test 2 active lever presses	0.3	0.4	0.7	0.4	-0.6	0.8	0.6
Progressive ratio test 2 breakpoint	0.3	0.4	0.7	0.5	-0.6	0.8	0.5
Progressive ratio test 2 inactive lever presses	0.2	0.8	1.4	0.4	-0.8	1.2	1.0
Incentive Sensitization - Responses	0.1	0.2	0.4	0.4	-0.5	0.6	-0.1
Incentive Sensitization - Breakpoint	0.1	0.2	0.2	0.5	-0.5	0.5	-0.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.2	-0.4	0.4	0.1
Progressive ratio	0.2	0.5	0.6	-0.7	0.8	-0.8	0.6
Food seeking constrained by brief footshock	0.3	0.4	1.0	0.7	-0.0	-0.3	-1.0
Seeking ratio, punishment vs. effort	0.5	1.0	1.6	1.3	-0.8	0.4	-1.3
Retroperitoneal fat weight	0.1	0.5	0.7	-0.6	0.8	-0.8	-0.6
Reaction time number correct	0.3	1.2	2.9	-1.2	0.4	0.3	1.7
Reaction time mean minus median	0.2	1.3	2.6	-0.8	1.4	-1.6	-0.3
Reaction time mean minus median AUC	0.2	1.0	1.8	-0.9	1.2	-1.3	-0.0
Reaction time num false alarms	0.2	0.3	0.5	-0.5	0.7	-0.6	0.2
Reaction time num false alarms AUC	0.2	0.5	1.0	-0.6	1.0	-0.9	0.1
Reaction time trials correct on left	0.3	1.2	2.9	-1.2	0.4	0.3	1.7
Reaction time trials on left	0.3	1.1	2.7	-1.3	0.4	0.2	1.6
Reaction time mean	0.3	0.6	1.4	0.2	0.4	-0.9	-1.2
Reaction time mean AUC	0.2	0.5	1.1	0.4	0.2	-0.8	-1.0
Median of all reaction times	0.3	0.4	1.2	0.5	-0.1	-0.4	-1.1
Reaction time omissions	0.5	0.9	1.2	-0.9	1.1	-1.1	-0.5
Reaction time false alarm rate	0.3	0.4	0.7	0.1	0.6	-0.9	-0.7
Reaction time premature initiation rate	1.2	1.9	3.6	0.0	1.1	-1.7	-1.9
Reaction time premature initiations	0.5	1.4	2.5	-0.6	1.3	-1.6	-1.0
Std. dev. reaction times	0.6	2.1	4.1	-0.7	1.6	-2.0	-1.0
Reaction time trials completed	0.3	1.1	2.7	-1.3	0.4	0.2	1.6
Reaction time trials AUC	0.3	1.1	2.8	-1.2	0.3	0.4	1.7
Run reversals in cocaine runway, females	1.2	1.4	2.7	1.0	-1.4	1.6	0.2
Run reversals in cocaine runway, males	0.8	0.9	2.5	1.6	-0.8	0.2	-0.6
Latency to leave start box in cocaine runway	1.8	2.5	5.3	-2.3	1.7	-1.0	0.8
Latency to leave start box in cocaine runway, F	2.4	3.0	6.2	-2.5	1.7	-0.8	1.5
Latency to leave start box in cocaine runway, M	0.4	0.4	0.7	-0.8	0.7	-0.5	-0.4
Std. dev. time between licks in bursts	0.2	0.3	0.5	0.7	-0.7	0.3	-0.2
Total sessions with >9 infusions	0.1	0.1	0.3	0.1	-0.2	0.5	0.4
Short access day 1 total inactive lever presses	0.5	0.9	2.0	-0.8	-0.3	1.4	1.0
Short access day 10 total inactive lever presses	0.0	0.2	0.4	0.3	-0.2	-0.1	-0.7
Short access day 1 total infusions	0.7	1.4	2.5	1.1	-1.3	1.6	0.3
Short access day 10 total infusions	0.2	0.4	0.9	0.9	-0.6	0.5	-0.2
Short access total infusions	0.2	0.2	0.5	0.5	-0.5	0.7	0.2
Short access day 1 locomotion	1.2	2.0	4.4	-0.4	-0.7	1.7	2.1
Short access day 10 total locomotion	0.2	0.7	0.9	0.8	-0.9	0.9	0.8
Short access total locomotion	0.5	0.8	1.7	0.2	-0.6	1.1	1.3
One hour access (0.3 mA shock)	0.1	0.1	0.3	-0.4	0.2	0.0	0.6
Compulsive drug intake	1.1	1.6	2.4	-1.5	1.4	-1.3	-0.6
One hour access (shock baseline)	0.0	0.1	0.5	0.1	-0.0	-0.0	0.7
Social response proportion	0.8	1.0	2.0	-1.1	-0.0	0.8	1.4
Social responses	0.6	0.8	1.3	-1.1	0.8	-0.3	1.1
Social time	0.0	0.0	0.1	-0.0	0.2	-0.3	-0.1
Soleus weight	0.3	1.0	2.0	-1.4	0.9	-0.4	1.0
Bone: stiffness	0.5	1.0	1.5	-1.0	1.1	-1.2	-0.5
Tibialis anterior weight	0.1	0.5	0.8	-0.9	0.6	-0.3	0.8
Time to tail flick, vehicle, before self-admin	1.4	1.8	3.1	0.9	-1.5	1.8	1.0
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.2	-0.5	0.2	-0.0	0.2
Time to tail flick, test, before self-admin	0.4	0.5	1.6	-0.3	0.0	0.3	1.3
Time to tail flick, test, after self-admin	0.5	0.6	1.3	0.2	-0.8	1.1	0.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.4	0.5	-0.5	0.7	-0.7	-0.6
Delta time to tail flick, test, before/after SA	0.4	0.5	0.7	0.6	-0.7	0.7	-0.8
Tibia length	0.2	0.4	0.8	-0.2	0.6	-0.7	-0.9
Ambulatory time before self-admin	0.1	0.4	0.9	0.0	-0.4	0.7	0.9
Ambulatory time after self-admin	0.4	0.6	1.4	-0.9	0.2	0.4	1.2
Bone: tissue strength	0.3	0.3	0.5	-0.7	0.7	-0.5	0.4
Total heroin consumption	0.1	0.1	0.3	0.5	-0.2	0.1	-0.2
Bone: trabecular number	0.2	0.3	0.7	-0.6	0.1	0.2	0.8
Bone: trabecular spacing	0.5	0.7	1.2	0.0	0.6	-1.0	-1.1
Bone: trabecular thickness	0.7	1.0	1.8	-1.3	1.2	-0.8	-0.0
Bone: trabecular tissue density	0.3	0.6	1.3	-1.2	0.6	-0.5	0.5
Water consumed over 24 hours	0.3	0.5	0.8	0.7	-0.8	0.9	-0.1
Number of responses in last shaping day	0.0	0.1	0.1	-0.2	0.1	0.2	0.4