Cyp26a1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Cyp26a1	0.03	0.02	2.3e-03	0	0	0	-0	2.2e-01	1.9e-01	2.8e-01	8.8e-01
2	NAcc	gene expression	Cyp26a1	0.04	0.03	4.8e-05	0.04	0.04	0.04	0.04	2.8e-05	1.3e-05	3.1e-05	1.9e-05
3	IL	gene expression	Cyp26a1	0.32	0.12	1.0e-07	0.18	0.17	0.17	0.17	4.1e-05	5.7e-05	6.1e-05	6.2e-05
4	OFC	gene expression	Cyp26a1	0.32	0.13	3.4e-05	0.14	0.2	0.14	0.17	2.7e-04	1.7e-05	3.3e-04	7.9e-05
5	PL	gene expression	Cyp26a1	0.22	0.07	0.0e+00	0.13	0.22	0.23	0.23	5.4e-14	2.0e-24	9.7e-25	1.8e-25
6	Brain	gene expression	Cyp26a1	0.07	0.03	2.1e-05	0.06	0.05	0.03	0.05	1.2e-06	4.2e-05	8.9e-04	1.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	6.0	10.0	15.1	3.1	3.5	-3.2	3.9	3.2	-1.8
Area under the delay curve	0.6	0.7	2.1	-1.4	-1.0	0.8	-0.3	-0.3	0.2
BMI with tail	0.1	0.3	1.2	0.6	1.1	0.0	0.4	0.1	-0.2
BMI without tail	0.3	0.7	1.9	1.0	1.0	-1.4	0.2	0.3	0.2
Body weight	0.8	3.3	5.2	1.7	1.6	-1.2	2.1	1.8	-2.3
Weight adjusted by age	0.5	0.5	1.6	-1.3	-0.3	0.9	0.2	0.2	0.6
Bone surface	4.7	8.2	11.1	3.1	3.1	-3.3	3.2	2.8	-0.9
Bone volume	5.1	8.7	11.6	3.0	3.1	-3.2	3.4	3.0	-1.6
Breakpoint value in progressive ratio session	0.8	0.8	2.2	-0.4	0.1	0.5	1.1	1.2	-1.5
Number of licking bursts	2.9	3.4	4.9	-2.2	-2.2	1.5	-1.9	-1.9	1.2
Context. condit. distance diff. score	1.9	2.3	5.6	1.2	1.6	-0.7	1.4	1.4	-2.4
Locomotion velocity, session 1	3.8	4.1	9.0	-1.3	-1.7	1.2	-2.0	-2.4	3.0
Locomotion distance, session 1	0.5	0.6	0.8	-0.8	-0.8	0.8	-0.6	-0.8	0.9
Locomotion velocity, session 2	0.8	0.9	1.9	0.3	-0.2	-0.8	-1.1	-1.3	1.4
Locomotion distance, session 2	0.3	0.4	1.0	-0.3	-0.7	0.1	-0.8	-1.0	0.1
Locomotion velocity, session 3	0.3	0.3	0.7	0.8	0.6	-0.5	0.3	0.0	-0.7
Locomotion distance, session 3	0.9	1.0	3.0	1.3	0.7	-0.9	0.1	0.2	-1.7
Stereotopy head waving bouts, day 3	0.3	0.3	1.4	0.3	0.5	-0.1	0.2	-0.2	1.2
Stereotopy head waving duration, day 3	0.4	0.4	1.1	-0.3	0.6	-0.0	0.6	0.8	1.1
Locomotion velocity, session 7	1.6	1.8	3.4	0.7	1.3	-1.4	0.9	1.9	-1.6
Locomotion distance, session 7	1.5	1.8	2.9	1.0	1.2	-1.5	0.8	1.7	-1.7
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.0	0.2	0.1	0.2	-0.2	0.5
Stereotopy head waving duration, day 7	0.2	0.3	0.6	0.7	0.8	-0.3	0.5	0.1	0.6
Locomotion velocity, session 8	0.3	0.4	0.6	0.5	0.8	-0.3	0.7	0.8	-0.7
Locomotion distance, session 8	0.3	0.5	2.6	0.3	0.5	0.1	0.3	0.2	-1.6
Degree of sensitization distance	0.5	0.5	1.7	-1.0	-0.0	0.1	0.3	1.3	-0.0
Degree of sensitization stereotypy	0.1	0.1	0.2	0.4	0.2	0.1	0.4	-0.2	0.0
Conditioned locomotion	0.2	0.3	1.1	0.3	0.3	-0.0	0.5	0.3	-1.1
Cocaine response after cond. corrected	0.0	0.0	0.1	0.1	-0.4	-0.2	-0.1	-0.3	-0.1
Cocaine response after cond. not corrected	0.1	0.1	0.6	0.0	-0.3	-0.2	0.1	0.2	-0.8
Cocaine response before conditioning	0.1	0.1	0.4	-0.5	-0.0	0.2	0.1	0.6	-0.5
Saline control response	1.7	2.2	5.9	-2.3	-1.4	2.4	-0.1	0.1	-0.5
Bone: connectivity density	4.9	7.7	11.5	3.0	3.4	-3.1	3.0	2.6	-0.8
Bone: cortical apparent density	1.3	1.7	3.4	-1.8	-1.1	1.4	-1.2	-0.7	1.4
Bone: cortical area	3.1	4.7	5.5	2.2	1.7	-2.3	2.2	2.3	-2.2
Bone: cortical porosity	0.1	0.1	0.2	-0.3	0.4	-0.2	0.1	0.5	0.2
Bone: cortical porosity	0.4	0.4	0.9	0.5	0.8	-0.9	0.4	0.8	-0.1
Bone: cortical thickness	0.2	0.3	0.9	-0.3	-0.8	0.3	0.1	0.1	-1.0
Bone: cortical thickness	1.1	1.3	2.7	-1.5	-1.7	1.0	-0.9	-0.8	0.2
Bone: cortical tissue density	1.4	1.8	3.4	-1.9	-1.1	1.4	-1.2	-0.8	1.5
Condit. Reinf. active minus inactive responses	0.8	0.9	2.0	-0.2	-1.1	-0.1	-1.4	-1.3	0.4
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.9	0.1	-0.8	-0.0	-1.3	-1.4	1.2
Condit. Reinf. active responses	0.2	0.2	0.7	-0.1	-0.5	-0.2	-0.4	-0.2	-0.8
Condit. Reinf. inactive responses	0.5	0.6	2.1	-0.2	0.1	0.0	0.7	0.9	-1.4
Incentive salience index mean	1.2	1.4	2.9	-0.8	-1.7	0.5	-1.7	-1.4	-0.2
Condit. Reinf. lever presses	1.9	2.5	4.5	-1.8	-2.1	1.7	-1.6	-1.3	0.0
Condit. Reinf. active minus inactive responses	1.0	1.2	2.5	0.6	1.0	-1.1	0.7	1.2	-1.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	-0.0	0.4	-0.4	0.1	0.4	-0.6
Condit. Reinf. active responses	1.5	2.0	3.7	0.9	1.3	-0.8	1.6	1.7	-1.9
Condit. Reinf. inactive responses	0.7	0.8	1.6	0.8	0.6	-0.2	1.3	1.0	-1.2
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.2	-0.3	0.1	0.3	0.2	-0.1
Condit. Reinf. lever reinforcers received	0.8	1.1	2.5	0.5	0.8	-0.5	1.2	1.3	-1.6
Conditioned reinforcement - actives	2.3	2.3	3.5	1.7	1.3	-1.9	1.5	1.4	-1.3
Conditioned reinforcement - inactives	3.0	3.3	5.6	2.4	2.1	-2.2	1.6	1.3	-0.9
Conditioned locomotion	1.6	1.9	2.6	1.4	1.4	-1.5	1.6	1.6	-0.1
Patch foraging indifference point 0 sec	0.2	0.3	0.8	0.4	-0.7	-0.1	-0.2	-0.9	0.5
Patch foraging indifference point AUC	1.4	1.6	3.4	-1.8	-1.6	1.8	-0.6	0.0	0.3
Delay disc. indifference point, 0s delay	0.5	0.5	1.9	-0.7	0.2	0.3	0.3	0.7	-1.4
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.5	-0.1	0.5	0.6	0.3	0.1
Delay disc. indifference point, 2s delay	0.3	0.3	1.2	-1.1	-0.4	0.2	0.0	0.0	0.6
Delay disc. indifference point, 24s delay	0.6	0.6	1.4	-1.2	-1.1	0.7	-0.6	-0.1	0.1
Delay disc. indifference point, 4s delay	0.7	0.7	2.4	-1.5	-0.9	0.7	-0.1	-0.0	-0.6
Delay disc. indifference point, 8s delay	3.1	3.2	6.2	-2.5	-2.2	1.8	-1.2	-1.3	1.4
Indifference point function ln k	2.3	3.2	6.4	2.5	2.1	-2.5	1.1	0.6	-0.9
Indifference point function log k	2.3	3.2	6.4	2.5	2.1	-2.5	1.1	0.6	-0.9
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	0.4	-0.5	-0.1	-0.1	-0.7	0.5
Patch foraging total patch changes 12 sec	2.3	3.0	5.2	-2.0	-2.1	2.3	-1.2	-1.2	1.2
Patch foraging total patch changes 18 sec	0.7	0.9	2.0	-1.1	-1.1	1.4	-0.5	-0.6	0.6
Patch foraging total patch changes 24 sec	0.1	0.1	0.6	-0.1	-0.8	0.4	-0.1	-0.0	-0.2
Patch foraging total patch changes 6 sec	1.2	1.7	3.5	-0.9	-1.9	1.4	-1.0	-1.2	1.3
Patch foraging time to switch 0 sec	1.7	2.6	3.7	-1.7	-1.7	1.9	-1.5	-1.9	0.9
Patch foraging water rate 0 sec	1.2	1.9	4.7	1.5	1.4	-2.2	0.8	1.2	-0.5
Patch foraging water rate 12 sec	1.0	1.6	4.8	1.8	1.0	-2.2	0.5	0.4	-0.4
Patch foraging water rate 18 sec	1.8	2.4	5.7	1.9	1.3	-2.4	0.9	0.8	-1.3
Patch foraging water rate 24 sec	1.3	1.8	3.4	1.2	1.0	-1.7	1.1	1.0	-1.9
Patch foraging water rate 6 sec	0.4	0.5	2.0	0.8	0.6	-1.4	0.3	0.3	0.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.6	0.1	0.0	0.7	0.1	0.1	-0.7
Distance traveled before self-admin	0.1	0.1	0.4	0.3	0.1	-0.1	-0.6	-0.6	-0.2
Distance traveled after self-admin	0.8	0.9	1.8	0.6	1.3	-1.3	0.7	1.0	0.4
Extensor digitorum longus weight	0.6	2.2	6.6	0.1	1.1	0.0	1.2	1.9	-2.6
Bone: elastic displacement	1.9	2.1	6.8	-1.2	-0.6	0.9	-1.3	-1.3	2.6
Bone: elastic work	0.8	1.1	5.3	-0.5	0.1	-0.1	-0.7	-0.5	2.3
Bone: endosteal estimation	7.4	16.2	21.0	4.2	4.2	-4.6	4.1	4.4	-2.1
Bone: endosteal perimeter	6.7	13.8	17.1	4.1	3.9	-4.1	3.9	3.7	-2.1
Epididymis fat weight	0.2	0.4	1.2	0.3	0.4	-0.7	0.4	0.4	-1.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.2	-0.6	-0.3	-0.7	-0.6	-0.1
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.3	0.3	-0.2	0.0	0.5	-0.1
Diff in mean of infusions in LGA sessions	0.8	0.9	1.2	0.9	1.1	-0.9	0.6	1.1	-0.9
Delay discount exponential model param	0.7	0.7	2.1	1.4	1.1	-0.8	0.3	0.4	-0.2
Extinction: sum of active levers before priming	0.4	0.4	0.8	0.6	0.5	-0.6	0.6	0.6	-0.9
Active lever presses in extinction session 6	1.8	1.8	3.0	0.6	1.2	-1.2	1.4	1.5	-1.7
Bone: final force	1.1	1.8	2.5	1.4	0.9	-1.6	1.4	1.4	-1.0
Bone: final moment	1.1	1.8	3.0	1.6	1.0	-1.7	1.4	1.4	-0.6
Food consumed during 24 hour testing period	0.2	0.3	0.5	0.6	-0.4	-0.6	-0.7	-0.6	0.2
Glucose	0.4	0.6	1.0	0.9	0.8	-0.6	0.5	1.0	-0.4
Heart weight	0.4	0.5	1.3	1.0	0.1	-0.9	-0.2	-0.1	1.1
Delay discount hyperbolic model param	0.6	0.7	2.0	1.4	1.0	-0.7	0.4	0.4	-0.4
Intermittent access intake day 1-15 change	5.0	4.9	9.7	3.1	2.4	-2.9	2.0	1.3	-0.6
Intermittent access intake escalation	4.3	4.3	9.9	3.1	2.1	-2.8	1.7	0.8	-0.5
Intermittent access intake escalation 2	3.3	3.3	8.0	2.8	1.9	-2.6	1.1	0.3	-0.2
Intermitt. access day 1 inactive lever presses	0.2	0.2	1.1	0.2	0.3	0.1	0.0	-0.1	1.1
Intermitt. access day 15 inactive lever presses	2.1	2.3	3.8	1.3	1.8	-1.0	1.9	1.9	0.6
Intermitt. access escalation Index	0.1	0.1	0.3	0.1	0.5	0.0	0.0	0.5	-0.4
Intermittent access day 1 total infusions	1.3	1.5	2.9	0.8	1.2	-1.1	1.1	1.7	-1.3
Intermittent access day 15 total infusions	6.3	7.1	11.9	3.5	2.8	-3.1	2.4	2.1	-1.6
Intermittent access terminal intake (last 3 days)	4.5	4.9	7.5	2.7	2.5	-2.7	2.0	1.9	-1.0
Intermittent access total infusions	2.9	3.2	4.2	2.0	2.1	-1.8	1.6	1.8	-1.4
Intermittent access day 1 locomotion	0.6	0.6	1.5	0.7	0.7	-0.7	0.6	1.2	-0.7
Intermittent access day 15 total locomotion	0.9	0.9	2.0	1.2	0.9	-0.7	1.4	0.9	-0.2
Intermittent access total locomotion	0.3	0.3	0.8	0.2	0.5	-0.1	0.7	0.9	-0.5
Intermittent access standard deviation	4.5	4.8	10.6	3.0	2.1	-3.3	1.4	1.5	-0.5
Left kidney weight	0.3	0.9	2.2	1.1	0.4	-0.8	0.7	0.7	-1.5
Right kidney weight	0.1	0.3	1.2	0.5	-0.6	0.1	0.0	0.1	-1.1
Cocaine induced anxiety	0.4	0.4	1.0	-0.8	-0.4	1.0	-0.5	-0.4	-0.6
Post-drug Anxiety	1.5	1.7	5.1	-2.0	-0.9	2.3	-0.3	-0.4	0.4
Baseline Anxiety	0.3	0.3	0.7	-0.6	-0.3	0.7	0.3	0.2	0.8
Tail length	0.9	2.7	5.1	1.4	0.8	-2.3	1.2	1.9	-1.8
Length with tail	1.0	3.8	7.5	1.4	0.8	-1.7	2.1	2.3	-2.7
Length without tail	1.1	2.3	8.4	0.6	0.4	-0.3	1.6	1.5	-2.9
Times rat made contact with spout	0.2	0.2	1.0	-1.0	-0.3	0.1	-0.2	0.4	-0.3
Lifetime Intake	2.2	2.5	3.1	1.6	1.8	-1.6	1.5	1.7	-1.2
Liver weight, left	1.7	2.8	7.2	1.5	0.9	-0.7	1.7	1.8	-2.7
Liver weight, right	0.8	1.3	4.6	0.2	0.4	0.1	0.9	1.5	-2.1
Locomotor activity	0.5	0.8	2.4	0.1	-0.5	0.7	-1.0	-1.6	0.8
Locomotor testing distance	0.6	1.0	2.8	0.2	-0.5	0.3	-1.1	-1.7	1.2
Locomotor testing rearing	0.2	0.2	0.5	0.7	0.6	-0.0	0.3	-0.0	-0.7
Locomotion in novel chamber	1.7	2.1	3.9	1.7	2.0	-1.6	1.4	0.8	-0.8
Locomotion in novel chamber post-restriction	1.4	1.7	5.9	0.5	0.7	-0.3	1.4	1.2	-2.4
Fecal boli incidents, locomotor time 1	0.4	0.4	0.8	-0.1	0.8	0.5	0.4	0.9	-0.7
Change in fecal boli incidents, locomotor task	0.5	0.5	1.4	-0.2	-0.8	0.8	-0.5	-1.2	0.3
Time >=10cm from walls, locomotor time 1	2.6	2.6	7.0	1.9	1.1	-1.0	1.1	1.4	-2.6
Bouts of movement, locomotor time 1	0.2	0.2	0.7	0.1	0.2	0.1	0.8	0.4	-0.8
Total resting periods, locomotor time 1	0.3	0.3	0.9	-0.1	0.1	0.2	0.9	0.5	-0.9
Rest time, locomotor task time 1	0.2	0.3	0.7	-0.4	0.5	0.2	0.8	0.6	0.1
Distance moved, locomotor task time 1	0.2	0.3	0.9	0.1	-0.7	-0.2	-1.0	-0.3	-0.3
Vertical activity count, locomotor time 1	0.3	0.4	0.6	0.6	-0.7	-0.5	-0.8	-0.7	0.1
Time >=10cm from walls, locomotor time 2	0.5	0.5	2.7	0.4	-0.0	-0.3	-0.1	0.3	-1.6
Bouts of movement, locomotor time 2	2.9	3.1	4.8	-2.2	-2.2	1.4	-1.9	-1.9	0.7
Total resting periods, locomotor time 2	2.7	2.9	4.6	-2.2	-2.1	1.3	-1.8	-1.8	0.5
Rest time, locomotor task time 2	0.5	0.5	1.1	-0.9	-0.7	1.0	0.2	-0.3	-0.9
Distance moved, locomotor task time 2	0.4	0.5	1.1	0.9	0.6	-1.1	-0.2	0.6	-0.4
Vertical activity count, locomotor time 2	0.4	0.4	0.9	0.5	-0.1	-0.9	-0.8	-0.0	0.9
Light reinforcement 1	0.1	0.2	0.6	-0.3	0.1	0.8	0.6	0.0	0.2
Light reinforcement 2	2.6	3.5	5.8	-2.2	-1.4	2.0	-1.4	-1.3	2.4
Bone: marrow area	7.7	16.7	21.0	4.2	4.3	-4.6	4.2	4.5	-2.1
Bone: maximum diameter	9.2	16.9	20.6	4.3	4.4	-4.1	4.5	4.2	-3.0
Bone: maximum force	2.9	5.0	6.4	2.3	2.1	-2.5	2.5	2.4	-1.2
Bone: maximum moment	2.9	4.9	6.7	2.4	2.1	-2.6	2.5	2.4	-0.8
Mean time between licks in bursts	0.6	0.8	2.4	0.2	-0.5	0.2	-1.0	-1.1	1.6
Mean num. licks in bursts	2.5	3.0	4.7	1.6	2.1	-1.6	1.6	2.2	-1.2
Cd content in liver	0.4	0.5	0.9	-0.0	-0.9	0.3	-0.7	-1.0	0.8
Co content in liver	1.1	1.3	4.7	-0.4	-0.8	0.4	-0.9	-1.2	2.2
Cu content in liver	3.7	4.5	8.0	-2.4	-2.2	2.1	-1.2	-1.5	2.8
Fe content in liver	4.7	5.6	10.0	-1.8	-2.3	2.1	-2.6	-3.2	2.0
K content in liver	0.9	0.9	2.1	-1.4	-1.0	1.2	-0.9	-0.6	-0.1
Mg content in liver	1.9	2.0	2.4	-1.5	-1.5	1.5	-1.4	-1.5	0.8
Mn content in liver	3.2	3.6	5.3	-2.3	-2.1	2.3	-1.6	-1.9	0.9
Na content in liver	3.4	3.6	6.3	-2.5	-1.9	2.3	-1.8	-1.5	0.3
Rb content in liver	0.2	0.2	0.6	0.1	0.1	-0.6	0.3	0.6	-0.7
Se content in liver	25.3	31.0	35.3	-5.5	-5.9	5.4	-5.4	-5.6	5.4
Sr content in liver	0.6	0.5	1.0	1.0	0.8	-0.6	0.5	0.3	0.9
Zn content in liver	7.0	7.7	11.7	-2.8	-2.8	2.3	-3.4	-2.7	2.5
Bone: minimum diameter	10.9	20.4	25.5	5.1	4.7	-4.8	4.4	4.6	-3.3
Time in familiar zone, hab. session 1	0.2	0.1	0.4	0.1	0.4	-0.4	0.4	0.1	0.6
Time in novel zone, hab. session 1	0.3	0.3	0.5	-0.7	-0.7	0.7	-0.7	-0.2	0.0
Total zone transitions, hab. session 1	0.0	0.0	0.1	0.0	0.0	0.1	0.2	-0.2	0.2
Total locomotion distance, hab. session 1	1.3	1.8	2.7	-1.5	-1.6	1.3	-1.2	-1.5	0.7
Locomotion velocity, hab. session 1	2.1	2.9	4.5	-1.9	-2.1	1.8	-1.6	-1.8	0.6
Time in familiar zone, hab. session 2	0.4	0.4	1.5	-0.2	-0.4	0.2	-0.4	-0.6	1.2
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	0.2	-0.0	0.2	0.3	-0.2
Total zone transitions, hab. session 2	0.4	0.5	1.1	-0.4	-0.8	0.7	-0.5	-1.1	0.6
Total locomotion distance, hab. session 2	0.8	1.0	1.9	-0.8	-1.3	0.8	-1.0	-1.4	0.6
Locomotion velocity, hab. session 2	1.0	1.3	2.1	-1.1	-1.5	1.1	-1.1	-1.4	0.4
Novel to familiar place preference ratio	1.0	1.1	2.2	0.7	1.1	-1.5	0.8	1.1	-0.8
Novelty place preference	1.3	1.3	2.3	0.8	1.3	-1.5	1.0	1.2	-0.8
Time in novel zone, NPP test	1.0	1.1	2.1	0.7	1.2	-1.4	0.8	1.1	-0.6
Total zone transitions, NPP test	0.7	1.0	1.7	-0.9	-1.3	1.0	-1.1	-1.1	0.2
Total locomotion distance, NPP test	2.3	3.2	5.0	-1.9	-2.2	1.7	-1.9	-1.7	1.0
Locomotion velocity, NPP test	2.0	2.9	4.7	-1.9	-2.2	1.6	-1.8	-1.6	0.7
Intraocular pressure	0.1	0.1	0.5	-0.0	0.1	0.2	0.7	0.4	0.2
Delta distance traveled before/after self-admin	1.7	1.9	4.0	0.6	1.6	-1.2	1.7	2.0	-0.3
Delta ambulatory time before/after self-admin	2.9	3.2	6.5	1.0	2.2	-1.4	2.1	2.6	-0.8
Parametrial fat weight	0.3	0.5	1.4	0.5	0.5	0.1	0.7	1.2	-0.9
Pavlov. Cond. lever latency	0.4	0.5	0.9	0.7	0.8	-0.2	0.9	0.4	0.7
Pavlov. Cond. magazine entry latency	1.3	1.7	3.7	-0.3	-1.7	0.2	-1.9	-1.8	0.4
Pavlov. Cond. change in total contacts	1.0	1.1	2.9	0.3	-0.9	-0.6	-1.7	-1.4	0.6
Pavlov. Cond. index score	0.9	1.1	2.2	-0.6	-1.5	0.3	-1.5	-1.2	-0.6
Pavlov. Cond. latency score	0.8	1.1	2.0	-0.7	-1.4	0.3	-1.4	-1.0	-0.9
Pavlov. Cond. lever contacts	0.8	1.0	1.8	-1.0	-1.4	0.7	-1.2	-0.7	-0.7
Pavlov. Cond. magazine entry number	0.6	0.7	1.5	-0.5	0.9	0.7	1.2	1.1	-0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.9	-0.1	0.1	0.1	0.5	0.5	-1.0
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	3.1	-0.7	-1.6	0.4	-1.8	-1.4	-0.4
Pavlov. Cond. response bias	1.1	1.4	3.2	-0.0	-1.4	-0.2	-1.8	-1.7	0.5
Pavlov. Cond. lever latency	0.2	0.3	0.9	0.4	1.0	-0.2	0.1	0.2	-0.8
Pavlov. Cond. magazine entry latency	0.6	0.7	1.9	0.1	-1.0	-0.5	-1.4	-1.0	0.4
Pavlov. Cond. change in total contacts	0.2	0.3	0.9	-0.7	-1.0	0.4	-0.5	-0.2	-0.1
Pavlov. Cond. index score	0.1	0.2	0.9	-0.2	-0.9	-0.2	-0.4	-0.1	-0.0
Pavlov. Cond. latency score	0.1	0.1	0.5	-0.0	-0.7	-0.4	-0.3	-0.0	-0.2
Pavlov. Cond. lever contacts	0.1	0.2	0.6	-0.4	-0.8	0.3	0.2	0.1	0.3
Pavlov. Cond. magazine entry number	1.5	1.8	3.7	0.9	1.9	-0.6	1.9	1.4	-0.6
Pavlov. Cond. intertrial magazine entries	0.7	0.8	2.7	0.3	0.9	-0.3	0.8	0.8	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.0	-0.3	-1.0	-0.2	-0.6	-0.3	-0.1
Pavlov. Cond. response bias	0.4	0.6	1.9	-0.7	-1.4	0.2	-0.8	-0.5	0.5
Time in closed arm before self-admin	0.1	0.1	0.2	-0.1	0.3	-0.5	-0.3	-0.1	0.2
Time in closed arm after self-admin	0.6	0.7	1.1	-1.0	-1.0	0.7	-0.9	-0.6	-0.4
Time in open arm before self-admin	0.2	0.2	0.5	-0.1	-0.2	0.3	-0.0	-0.6	0.7
Time in open arm after self-admin	0.1	0.2	0.4	0.4	0.3	-0.6	0.6	0.0	0.1
Bone: periosteal estimation	7.0	14.5	17.8	3.9	3.8	-4.1	4.1	4.2	-2.5
Bone: periosteal perimeter	5.9	9.8	11.1	3.2	3.1	-3.3	3.3	3.3	-2.6
Bone: post-yield work	3.8	5.1	6.7	2.6	2.1	-2.6	2.3	2.0	-2.0
Progressive ratio test 1 active lever presses	1.7	1.8	3.3	0.9	1.6	-0.8	1.7	1.8	-0.9
Progressive ratio test 1 breakpoint	1.7	1.8	3.5	0.9	1.6	-0.8	1.6	1.9	-0.7
Progressive ratio test 1 inactive lever presses	3.0	3.3	5.4	1.7	2.3	-1.6	2.0	2.1	-0.7
Progressive ratio test 2 active lever presses	5.4	5.8	7.7	2.7	2.7	-2.4	2.8	2.2	-1.5
Progressive ratio test 2 breakpoint	6.7	7.5	10.5	2.8	3.1	-2.5	3.2	2.8	-1.7
Progressive ratio test 2 inactive lever presses	2.3	2.7	4.4	1.8	2.1	-1.6	1.9	1.4	-0.5
Incentive Sensitization - Responses	5.9	6.0	8.8	3.0	2.8	-2.6	2.6	1.9	-1.3
Incentive Sensitization - Breakpoint	5.8	5.9	8.7	3.0	2.8	-2.6	2.6	1.9	-1.4
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.1	-0.0	-0.4	-0.5	-0.5	-0.8	1.1
Progressive ratio	0.6	0.7	2.4	0.1	-0.2	1.3	0.2	-0.4	-1.5
Food seeking constrained by brief footshock	1.7	2.0	5.9	2.4	0.9	-1.3	1.1	0.2	-1.6
Seeking ratio, punishment vs. effort	0.6	0.8	3.1	1.0	0.3	-1.8	0.2	0.2	0.4
Retroperitoneal fat weight	0.1	0.4	0.6	0.3	0.4	-0.7	0.6	0.8	-0.7
Reaction time number correct	1.0	1.4	1.9	1.0	1.3	-1.1	1.4	1.0	-1.3
Reaction time mean minus median	1.2	1.6	4.5	2.1	0.7	-1.9	-0.0	-0.4	0.8
Reaction time mean minus median AUC	0.9	1.1	2.0	1.4	0.1	-1.2	-0.6	-1.1	1.4
Reaction time num false alarms	0.6	0.8	3.4	-0.1	-0.0	-0.0	0.7	0.9	-1.8
Reaction time num false alarms AUC	0.4	0.5	2.4	0.1	-0.1	-0.2	0.4	0.6	-1.6
Reaction time trials correct on left	1.0	1.4	1.9	1.0	1.3	-1.1	1.4	1.0	-1.3
Reaction time trials on left	1.0	1.4	1.8	1.1	1.3	-1.2	1.3	0.9	-1.3
Reaction time mean	1.2	1.6	3.6	0.1	-0.9	-0.3	-1.7	-1.5	1.9
Reaction time mean AUC	1.5	2.1	4.7	-0.2	-1.1	0.1	-1.9	-1.7	2.2
Median of all reaction times	1.5	2.0	4.4	-0.6	-1.2	0.3	-1.9	-1.5	2.1
Reaction time omissions	0.8	1.1	2.9	1.7	0.3	-1.5	-0.8	-0.9	0.2
Reaction time false alarm rate	0.2	0.3	1.0	-0.4	-0.6	0.4	-0.0	0.2	-1.0
Reaction time premature initiation rate	0.4	0.5	1.9	0.6	-0.1	-0.6	0.5	0.4	-1.4
Reaction time premature initiations	1.4	2.0	5.1	1.3	0.8	-1.2	1.4	1.0	-2.3
Std. dev. reaction times	1.1	1.5	2.7	1.7	-0.1	-1.3	-0.9	-1.2	1.5
Reaction time trials completed	1.0	1.4	1.8	1.1	1.3	-1.2	1.3	0.9	-1.3
Reaction time trials AUC	0.7	0.9	1.5	0.7	1.0	-0.9	1.1	0.8	-1.2
Run reversals in cocaine runway, females	0.6	0.6	1.7	-0.6	-0.6	0.1	-0.6	-0.9	1.3
Run reversals in cocaine runway, males	0.6	0.6	1.4	-0.8	-1.0	1.2	-0.4	-0.5	0.1
Latency to leave start box in cocaine runway	1.0	1.1	2.0	1.3	1.4	-1.2	0.7	0.4	-0.7
Latency to leave start box in cocaine runway, F	1.2	1.3	2.7	1.3	1.7	-1.4	0.6	0.7	-0.5
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	0.7	0.1	-0.3	0.1	-0.6	-0.5
Std. dev. time between licks in bursts	1.9	2.3	3.3	-1.4	-1.6	1.6	-1.4	-1.4	1.8
Total sessions with >9 infusions	0.5	0.6	1.2	0.4	0.8	-0.5	1.0	1.1	-0.2
Short access day 1 total inactive lever presses	1.3	1.4	3.6	0.7	1.9	-0.9	1.4	1.1	0.6
Short access day 10 total inactive lever presses	0.8	0.8	1.6	-1.2	-0.6	1.0	-0.8	-0.5	1.1
Short access day 1 total infusions	0.1	0.1	0.3	-0.3	0.2	-0.3	0.4	0.5	0.2
Short access day 10 total infusions	0.1	0.1	0.4	0.4	0.3	-0.3	0.2	0.6	0.3
Short access total infusions	1.0	1.1	2.3	0.7	1.1	-1.0	1.2	1.5	-0.6
Short access day 1 locomotion	0.1	0.1	0.3	-0.4	0.3	0.3	0.4	0.5	0.1
Short access day 10 total locomotion	0.1	0.1	0.4	-0.3	-0.4	0.1	-0.6	-0.2	0.5
Short access total locomotion	0.3	0.3	0.6	-0.8	-0.3	0.6	-0.2	0.1	0.8
One hour access (0.3 mA shock)	10.4	12.1	15.1	3.9	3.8	-3.7	3.6	3.3	-2.5
Compulsive drug intake	2.0	2.0	2.9	1.5	1.7	-1.5	1.1	1.6	-1.1
One hour access (shock baseline)	2.2	2.6	4.0	2.0	1.6	-1.8	1.7	1.3	-1.1
Social response proportion	1.0	1.1	2.0	0.7	1.3	-1.4	0.8	1.2	0.3
Social responses	1.6	2.1	3.0	1.2	1.7	-1.4	1.7	1.7	0.0
Social time	0.3	0.4	0.7	-0.9	-0.8	0.6	-0.6	-0.2	0.7
Soleus weight	1.7	4.8	7.1	2.1	2.7	-2.1	2.5	2.6	-0.3
Bone: stiffness	3.8	6.0	9.1	2.0	2.2	-2.1	2.6	3.0	-2.7
Tibialis anterior weight	0.9	2.9	8.0	-0.1	1.2	-0.5	1.3	2.5	-2.8
Time to tail flick, vehicle, before self-admin	1.4	1.4	2.8	-1.7	-0.6	1.6	-0.4	-0.4	1.6
Time to tail flick, vehicle, after self-admin	1.0	1.0	4.0	0.0	0.4	-0.2	0.7	1.2	-2.0
Time to tail flick, test, before self-admin	2.4	2.4	3.7	1.1	1.7	-0.9	1.4	1.9	-1.9
Time to tail flick, test, after self-admin	0.2	0.2	0.4	-0.7	0.2	0.3	0.2	0.5	0.4
Delta time to tail flick, vehicle, before/after SA	3.5	3.5	12.0	1.4	1.0	-1.4	1.3	1.6	-3.5
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.5	-0.3	0.2	-0.0	-0.2	0.3
Tibia length	0.1	0.2	0.4	0.6	-0.1	-0.5	0.4	0.2	-0.2
Ambulatory time before self-admin	0.5	0.5	1.4	-0.1	-0.4	0.4	-1.1	-1.2	0.3
Ambulatory time after self-admin	1.2	1.3	3.2	0.9	1.8	-1.3	0.8	1.2	-0.0
Bone: tissue strength	0.5	0.5	1.2	0.7	0.7	-0.5	0.4	0.6	1.1
Total heroin consumption	0.6	0.7	1.5	0.3	0.5	-0.1	1.1	1.0	-1.2
Bone: trabecular number	5.0	7.9	10.8	3.1	3.0	-3.3	3.1	2.6	-1.1
Bone: trabecular spacing	2.1	2.7	4.3	-1.6	-2.0	1.5	-2.1	-1.5	0.5
Bone: trabecular thickness	3.9	4.7	6.4	2.5	2.5	-2.3	2.4	1.8	-1.1
Bone: trabecular tissue density	1.1	1.5	2.5	0.6	1.3	-0.8	1.5	1.6	-1.3
Water consumed over 24 hours	0.2	0.2	0.6	-0.6	-0.2	-0.5	-0.8	0.2	-0.3
Number of responses in last shaping day	1.4	1.4	3.1	0.9	1.5	-0.5	1.8	1.4	-0.5