Hub : Genes

Cwc27

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative polyA XM_039102554.1 0.02 0.02 5.8e-03 0.02 0.01 0.02 0.02 3.7e-03 5.9e-03 7.9e-04 4.4e-03
2 Brain gene expression Cwc27 0.05 0.04 1.7e-05 0.04 0.05 0.05 0.04 1.4e-04 1.3e-05 2.4e-05 4.6e-05
3 NAcc gene expression Cwc27 0.02 0.02 2.3e-03 0.02 0.02 0.02 0.02 2.2e-03 1.7e-03 2.7e-03 2.3e-03
4 PL gene expression Cwc27 0.05 0.04 7.2e-08 0.06 0.03 0.04 0.03 4.4e-07 3.0e-04 1.4e-05 1.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.81.41.61.2-1.2-1.31.0
Area under the delay curve0.30.30.9-0.20.40.4-0.9
BMI with tail2.27.08.62.9-2.7-2.72.2
BMI without tail0.40.81.01.0-1.0-1.00.5
Body weight1.35.26.6-2.02.32.2-2.6
Weight adjusted by age0.20.20.5-0.20.30.3-0.7
Bone surface0.00.00.00.1-0.2-0.20.2
Bone volume0.10.20.20.4-0.5-0.50.4
Breakpoint value in progressive ratio session3.43.84.42.0-1.8-1.92.1
Number of licking bursts3.03.54.31.7-1.9-1.82.1
Context. condit. distance diff. score1.92.32.5-1.51.51.5-1.6
Locomotion velocity, session 10.60.60.8-0.80.70.7-0.9
Locomotion distance, session 10.70.91.0-0.90.90.9-1.0
Locomotion velocity, session 23.94.66.0-2.02.12.0-2.5
Locomotion distance, session 20.71.01.3-0.91.00.9-1.1
Locomotion velocity, session 35.15.96.6-2.42.42.4-2.6
Locomotion distance, session 38.49.29.8-3.13.03.0-3.0
Stereotopy head waving bouts, day 30.10.10.1-0.30.30.3-0.3
Stereotopy head waving duration, day 30.10.10.10.4-0.3-0.40.3
Locomotion velocity, session 70.20.20.2-0.40.40.5-0.4
Locomotion distance, session 70.50.70.8-0.80.80.8-0.9
Stereotopy head waving bouts, day 70.10.10.10.3-0.3-0.30.1
Stereotopy head waving duration, day 70.00.00.00.00.00.0-0.2
Locomotion velocity, session 82.42.83.6-1.61.61.6-1.9
Locomotion distance, session 84.46.57.4-2.52.52.5-2.7
Degree of sensitization distance3.93.94.32.1-1.9-1.92.0
Degree of sensitization stereotypy0.00.10.10.3-0.2-0.20.1
Conditioned locomotion0.00.00.1-0.0-0.1-0.10.3
Cocaine response after cond. corrected2.22.52.8-1.71.61.6-1.5
Cocaine response after cond. not corrected2.83.13.3-1.81.71.8-1.7
Cocaine response before conditioning0.20.20.2-0.40.50.4-0.5
Saline control response1.21.61.7-1.31.21.2-1.2
Bone: connectivity density0.20.30.40.6-0.6-0.60.3
Bone: cortical apparent density0.10.10.2-0.40.30.3-0.1
Bone: cortical area0.00.00.0-0.20.10.1-0.1
Bone: cortical porosity1.61.82.41.3-1.3-1.21.5
Bone: cortical porosity1.82.02.51.4-1.3-1.31.6
Bone: cortical thickness0.00.00.0-0.0-0.0-0.00.0
Bone: cortical thickness0.60.70.8-0.90.90.8-0.8
Bone: cortical tissue density0.10.10.2-0.50.40.4-0.2
Condit. Reinf. active minus inactive responses2.63.03.01.7-1.7-1.71.7
Condit. Reinf. active-inactive response ratio2.42.62.71.6-1.6-1.61.6
Condit. Reinf. active responses0.50.70.70.9-0.8-0.80.8
Condit. Reinf. inactive responses1.01.21.5-1.01.11.1-1.2
Incentive salience index mean1.82.22.31.5-1.5-1.51.5
Condit. Reinf. lever presses0.40.60.70.7-0.7-0.70.8
Condit. Reinf. active minus inactive responses3.94.84.9-2.22.22.2-2.2
Condit. Reinf. active-inactive response ratio2.32.42.7-1.71.51.6-1.4
Condit. Reinf. active responses1.21.71.9-1.31.31.3-1.4
Condit. Reinf. inactive responses0.00.10.2-0.10.20.1-0.4
Condit. Reinf. lever presses1.42.02.2-1.31.41.4-1.5
Condit. Reinf. lever reinforcers received1.62.32.6-1.51.51.5-1.6
Conditioned reinforcement - actives2.82.83.2-1.61.61.6-1.8
Conditioned reinforcement - inactives0.20.20.4-0.50.40.4-0.6
Conditioned locomotion0.50.61.0-1.00.80.8-0.4
Patch foraging indifference point 0 sec3.75.96.2-2.52.42.4-2.5
Patch foraging indifference point AUC0.80.91.10.9-1.0-1.00.7
Delay disc. indifference point, 0s delay0.30.30.40.5-0.5-0.50.6
Delay disc. indifference point, 16s delay1.21.32.1-1.01.01.0-1.4
Delay disc. indifference point, 2s delay0.30.30.50.7-0.5-0.50.6
Delay disc. indifference point, 24s delay1.31.22.2-0.91.01.0-1.5
Delay disc. indifference point, 4s delay0.10.10.20.5-0.2-0.30.1
Delay disc. indifference point, 8s delay0.10.10.30.3-0.0-0.1-0.6
Indifference point function ln k4.25.86.2-2.52.52.5-2.2
Indifference point function log k4.25.86.2-2.52.52.5-2.2
Patch foraging total patch changes 0 sec4.47.17.4-2.72.62.6-2.7
Patch foraging total patch changes 12 sec0.00.00.0-0.1-0.0-0.0-0.1
Patch foraging total patch changes 18 sec0.00.00.0-0.1-0.1-0.10.0
Patch foraging total patch changes 24 sec1.01.31.6-1.21.11.1-1.0
Patch foraging total patch changes 6 sec0.60.91.3-1.00.80.8-1.1
Patch foraging time to switch 0 sec5.07.78.32.6-2.8-2.82.9
Patch foraging water rate 0 sec4.57.27.9-2.62.72.6-2.8
Patch foraging water rate 12 sec4.87.47.8-2.82.82.8-2.5
Patch foraging water rate 18 sec5.16.97.8-2.62.82.7-2.4
Patch foraging water rate 24 sec2.43.43.6-1.91.91.8-1.8
Patch foraging water rate 6 sec13.619.920.0-4.54.54.5-4.5
Seeking ratio, delayed vs. immediate footshock1.61.82.11.5-1.4-1.41.0
Distance traveled before self-admin1.92.12.3-1.51.51.5-1.2
Distance traveled after self-admin2.02.23.0-1.71.41.5-1.2
Extensor digitorum longus weight4.818.719.94.5-4.4-4.53.9
Bone: elastic displacement1.31.41.61.2-1.2-1.21.3
Bone: elastic work0.60.80.90.8-0.8-0.81.0
Bone: endosteal estimation0.51.11.3-1.11.01.1-0.8
Bone: endosteal perimeter0.00.00.0-0.0-0.1-0.10.1
Epididymis fat weight0.10.30.40.6-0.4-0.50.5
Delta time in closed arm before/after self-admin3.63.53.61.9-1.9-1.91.9
Delta time in open arm before/after self-admin0.00.00.00.10.00.00.1
Diff in mean of infusions in LGA sessions0.30.30.50.5-0.6-0.50.7
Delay discount exponential model param0.30.30.90.1-0.4-0.30.9
Extinction: sum of active levers before priming2.12.12.51.5-1.3-1.31.6
Active lever presses in extinction session 62.01.92.01.4-1.4-1.41.4
Bone: final force0.81.31.5-1.21.11.1-1.0
Bone: final moment1.01.72.1-1.41.31.3-1.1
Food consumed during 24 hour testing period0.91.11.5-1.21.11.1-0.9
Glucose1.01.52.11.1-1.2-1.21.4
Heart weight0.30.40.60.5-0.6-0.60.7
Delay discount hyperbolic model param0.10.10.4-0.0-0.3-0.20.7
Intermittent access intake day 1-15 change0.00.00.1-0.20.20.2-0.3
Intermittent access intake escalation0.10.10.2-0.20.20.2-0.4
Intermittent access intake escalation 20.00.00.10.2-0.1-0.1-0.2
Intermitt. access day 1 inactive lever presses2.52.73.11.7-1.7-1.71.4
Intermitt. access day 15 inactive lever presses3.13.43.61.8-1.9-1.91.7
Intermitt. access escalation Index0.50.40.6-0.50.70.7-0.8
Intermittent access day 1 total infusions1.31.51.7-1.31.11.2-1.2
Intermittent access day 15 total infusions2.02.22.4-1.61.41.4-1.6
Intermittent access terminal intake (last 3 days)1.31.41.9-1.11.11.1-1.4
Intermittent access total infusions2.42.62.9-1.71.51.6-1.6
Intermittent access day 1 locomotion2.93.04.0-2.01.81.8-1.3
Intermittent access day 15 total locomotion1.71.92.6-1.61.31.4-1.1
Intermittent access total locomotion4.95.67.0-2.62.42.4-2.0
Intermittent access standard deviation0.10.10.10.0-0.3-0.30.2
Left kidney weight0.82.22.6-1.61.51.5-1.3
Right kidney weight0.20.60.6-0.80.80.7-0.8
Cocaine induced anxiety0.70.91.1-0.71.00.9-1.1
Post-drug Anxiety1.11.21.3-1.01.11.1-1.2
Baseline Anxiety0.00.00.00.0-0.0-0.0-0.0
Tail length7.522.823.4-4.84.84.7-4.8
Length with tail10.839.540.8-6.36.46.3-6.1
Length without tail6.313.714.7-3.63.83.8-3.6
Times rat made contact with spout0.20.20.60.2-0.4-0.40.8
Lifetime Intake2.12.42.6-1.61.51.5-1.6
Liver weight, left0.20.30.5-0.50.40.4-0.7
Liver weight, right0.00.00.0-0.0-0.1-0.00.1
Locomotor activity0.40.70.8-0.90.80.8-0.8
Locomotor testing distance0.20.30.40.5-0.6-0.60.6
Locomotor testing rearing0.10.20.30.2-0.4-0.30.6
Locomotion in novel chamber0.30.30.40.6-0.6-0.50.6
Locomotion in novel chamber post-restriction0.10.20.5-0.0-0.2-0.20.7
Fecal boli incidents, locomotor time 11.41.51.71.2-1.3-1.21.3
Change in fecal boli incidents, locomotor task0.00.00.00.2-0.1-0.1-0.2
Time >=10cm from walls, locomotor time 11.51.61.81.3-1.3-1.31.0
Bouts of movement, locomotor time 10.10.10.10.1-0.3-0.20.3
Total resting periods, locomotor time 10.00.00.1-0.40.10.2-0.1
Rest time, locomotor task time 10.80.91.90.5-0.9-0.91.4
Distance moved, locomotor task time 11.31.52.7-0.91.11.1-1.6
Vertical activity count, locomotor time 11.11.11.7-0.91.01.0-1.3
Time >=10cm from walls, locomotor time 21.21.21.60.9-1.1-1.11.3
Bouts of movement, locomotor time 20.10.20.3-0.30.40.3-0.5
Total resting periods, locomotor time 20.00.00.00.0-0.0-0.0-0.0
Rest time, locomotor task time 22.63.04.11.5-1.7-1.62.0
Distance moved, locomotor task time 21.31.62.2-1.21.21.1-1.5
Vertical activity count, locomotor time 20.20.20.3-0.50.50.4-0.5
Light reinforcement 12.24.04.4-2.01.92.0-2.1
Light reinforcement 20.10.20.20.5-0.4-0.40.4
Bone: marrow area0.51.01.2-1.11.01.1-0.8
Bone: maximum diameter0.50.91.00.9-1.0-1.00.9
Bone: maximum force0.10.20.3-0.50.50.5-0.4
Bone: maximum moment0.30.50.6-0.80.70.7-0.5
Mean time between licks in bursts0.30.40.50.7-0.6-0.60.7
Mean num. licks in bursts2.32.82.8-1.61.71.7-1.7
Cd content in liver0.40.40.8-0.40.60.5-0.9
Co content in liver0.10.10.2-0.10.20.2-0.4
Cu content in liver0.10.10.1-0.30.30.3-0.3
Fe content in liver1.11.31.5-1.11.11.1-1.2
K content in liver4.74.65.0-2.22.22.2-2.0
Mg content in liver1.41.51.6-1.31.21.2-1.1
Mn content in liver0.40.50.7-0.80.70.7-0.5
Na content in liver0.50.50.6-0.80.70.7-0.6
Rb content in liver0.70.91.0-0.90.90.9-1.0
Se content in liver0.30.30.50.7-0.6-0.60.5
Sr content in liver2.11.92.01.4-1.4-1.41.4
Zn content in liver0.00.00.00.1-0.0-0.00.0
Bone: minimum diameter2.03.84.3-2.12.02.0-1.7
Time in familiar zone, hab. session 14.74.44.6-2.12.12.1-2.1
Time in novel zone, hab. session 17.17.07.32.7-2.6-2.62.6
Total zone transitions, hab. session 10.00.00.10.10.00.0-0.3
Total locomotion distance, hab. session 10.20.30.3-0.50.60.6-0.6
Locomotion velocity, hab. session 10.20.30.3-0.50.50.6-0.6
Time in familiar zone, hab. session 22.22.32.6-1.61.51.6-1.3
Time in novel zone, hab. session 22.92.93.11.8-1.7-1.71.6
Total zone transitions, hab. session 20.30.30.4-0.60.60.6-0.6
Total locomotion distance, hab. session 20.10.10.1-0.40.20.3-0.2
Locomotion velocity, hab. session 20.30.40.5-0.70.60.7-0.6
Novel to familiar place preference ratio2.93.03.01.7-1.7-1.71.7
Novelty place preference2.32.42.41.5-1.5-1.61.5
Time in novel zone, NPP test2.52.52.71.6-1.6-1.61.5
Total zone transitions, NPP test1.72.43.2-1.41.51.5-1.8
Total locomotion distance, NPP test0.30.40.6-0.50.60.6-0.8
Locomotion velocity, NPP test1.01.41.7-1.11.21.2-1.3
Intraocular pressure6.28.610.43.2-2.9-3.02.6
Delta distance traveled before/after self-admin1.11.21.6-1.30.91.0-1.1
Delta ambulatory time before/after self-admin1.41.51.9-1.41.01.1-1.3
Parametrial fat weight0.10.20.30.5-0.4-0.50.1
Pavlov. Cond. lever latency0.00.00.10.3-0.2-0.20.1
Pavlov. Cond. magazine entry latency2.22.83.0-1.61.71.6-1.7
Pavlov. Cond. change in total contacts2.83.03.1-1.71.71.7-1.8
Pavlov. Cond. index score0.60.70.8-0.90.90.9-0.8
Pavlov. Cond. latency score0.20.20.3-0.50.50.5-0.4
Pavlov. Cond. lever contacts0.50.50.6-0.80.80.8-0.7
Pavlov. Cond. magazine entry number2.53.13.11.7-1.8-1.71.7
Pavlov. Cond. intertrial magazine entries7.69.210.63.3-3.1-3.12.6
Pavlov. Cond. lever-magazine prob. diff.0.81.01.0-1.01.01.0-0.9
Pavlov. Cond. response bias2.32.82.8-1.71.71.7-1.7
Pavlov. Cond. lever latency1.72.22.51.4-1.5-1.51.6
Pavlov. Cond. magazine entry latency1.11.21.4-1.01.21.1-1.1
Pavlov. Cond. change in total contacts5.27.27.5-2.62.72.7-2.7
Pavlov. Cond. index score2.53.23.4-1.71.81.8-1.8
Pavlov. Cond. latency score2.73.33.5-1.81.91.8-1.8
Pavlov. Cond. lever contacts1.72.32.5-1.51.51.5-1.6
Pavlov. Cond. magazine entry number2.22.72.91.6-1.7-1.71.6
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.10.00.0-0.3
Pavlov. Cond. lever-magazine prob. diff.2.63.43.5-1.71.91.8-1.9
Pavlov. Cond. response bias1.52.02.2-1.31.51.4-1.5
Time in closed arm before self-admin0.10.10.3-0.40.30.3-0.5
Time in closed arm after self-admin0.10.20.20.3-0.4-0.40.4
Time in open arm before self-admin0.00.00.00.00.0-0.00.0
Time in open arm after self-admin0.60.70.90.8-0.8-0.81.0
Bone: periosteal estimation0.20.40.5-0.70.60.7-0.5
Bone: periosteal perimeter0.00.00.0-0.20.10.1-0.1
Bone: post-yield work0.10.10.10.3-0.3-0.30.3
Progressive ratio test 1 active lever presses1.51.51.7-1.31.11.2-1.3
Progressive ratio test 1 breakpoint1.81.92.2-1.51.31.3-1.4
Progressive ratio test 1 inactive lever presses0.40.40.8-0.60.50.5-0.9
Progressive ratio test 2 active lever presses0.30.40.5-0.60.50.6-0.7
Progressive ratio test 2 breakpoint0.20.20.4-0.40.40.4-0.6
Progressive ratio test 2 inactive lever presses0.20.20.4-0.40.30.3-0.6
Incentive Sensitization - Responses0.40.40.6-0.40.60.6-0.7
Incentive Sensitization - Breakpoint0.20.20.4-0.20.40.4-0.6
Sum of active levers in priming session hrs 5-61.41.41.81.2-1.1-1.11.3
Progressive ratio0.20.20.50.3-0.4-0.50.7
Food seeking constrained by brief footshock2.22.73.3-1.81.81.8-1.1
Seeking ratio, punishment vs. effort1.31.61.8-1.21.31.3-1.1
Retroperitoneal fat weight0.82.53.31.8-1.7-1.71.0
Reaction time number correct9.313.413.7-3.63.73.7-3.7
Reaction time mean minus median0.10.10.1-0.30.30.3-0.4
Reaction time mean minus median AUC0.40.50.6-0.60.70.7-0.8
Reaction time num false alarms1.01.41.51.2-1.2-1.21.2
Reaction time num false alarms AUC1.72.32.41.5-1.5-1.51.5
Reaction time trials correct on left9.313.413.7-3.63.73.7-3.7
Reaction time trials on left9.513.513.8-3.63.73.7-3.7
Reaction time mean1.62.22.41.6-1.5-1.51.3
Reaction time mean AUC1.31.72.01.4-1.3-1.31.2
Median of all reaction times2.93.94.42.1-2.0-2.01.8
Reaction time omissions0.00.10.1-0.10.30.3-0.2
Reaction time false alarm rate7.410.410.63.2-3.2-3.33.2
Reaction time premature initiation rate4.66.16.5-2.62.52.6-2.2
Reaction time premature initiations12.617.718.3-4.34.34.3-4.0
Std. dev. reaction times0.10.10.10.4-0.3-0.30.2
Reaction time trials completed9.513.513.8-3.63.73.7-3.7
Reaction time trials AUC8.412.012.3-3.43.53.5-3.5
Run reversals in cocaine runway, females1.11.01.81.3-1.0-1.00.7
Run reversals in cocaine runway, males0.00.00.1-0.10.20.2-0.3
Latency to leave start box in cocaine runway2.32.53.31.4-1.5-1.51.8
Latency to leave start box in cocaine runway, F0.40.40.70.6-0.6-0.60.8
Latency to leave start box in cocaine runway, M2.12.02.31.5-1.5-1.51.2
Std. dev. time between licks in bursts0.60.81.20.7-0.8-0.81.1
Total sessions with >9 infusions1.21.41.7-1.21.11.1-1.3
Short access day 1 total inactive lever presses0.00.00.10.0-0.1-0.1-0.3
Short access day 10 total inactive lever presses0.30.40.50.6-0.7-0.70.5
Short access day 1 total infusions1.41.51.9-1.21.11.2-1.4
Short access day 10 total infusions1.92.12.4-1.51.31.4-1.5
Short access total infusions2.12.42.6-1.61.51.5-1.6
Short access day 1 locomotion0.30.30.4-0.50.60.6-0.5
Short access day 10 total locomotion0.10.10.2-0.40.20.20.1
Short access total locomotion2.32.43.2-1.81.61.6-1.2
One hour access (0.3 mA shock)0.70.81.4-0.80.80.8-1.2
Compulsive drug intake0.60.60.90.9-0.7-0.70.6
One hour access (shock baseline)2.93.44.0-2.01.71.8-1.8
Social response proportion0.10.10.20.3-0.4-0.40.2
Social responses1.41.82.6-1.21.31.3-1.6
Social time0.00.00.0-0.0-0.1-0.10.2
Soleus weight0.31.01.21.0-1.1-1.10.8
Bone: stiffness0.30.50.6-0.70.70.7-0.7
Tibialis anterior weight2.69.09.43.0-3.1-3.12.8
Time to tail flick, vehicle, before self-admin4.74.85.4-2.32.22.2-2.0
Time to tail flick, vehicle, after self-admin1.01.11.4-0.81.21.1-1.0
Time to tail flick, test, before self-admin0.10.10.1-0.10.30.2-0.3
Time to tail flick, test, after self-admin0.80.81.50.8-0.7-0.71.2
Delta time to tail flick, vehicle, before/after SA2.12.12.61.6-1.3-1.41.5
Delta time to tail flick, test, before/after SA0.10.10.10.2-0.2-0.20.3
Tibia length6.017.018.3-4.34.14.1-3.9
Ambulatory time before self-admin0.50.50.6-0.70.80.7-0.6
Ambulatory time after self-admin1.41.52.2-1.51.21.2-1.1
Bone: tissue strength1.01.01.20.9-1.0-1.01.1
Total heroin consumption1.21.42.21.1-1.1-1.11.5
Bone: trabecular number0.10.10.20.3-0.3-0.40.1
Bone: trabecular spacing0.00.10.10.3-0.2-0.20.3
Bone: trabecular thickness1.11.31.41.2-1.2-1.21.0
Bone: trabecular tissue density2.02.83.51.6-1.6-1.61.9
Water consumed over 24 hours0.40.50.80.5-0.7-0.70.9
Number of responses in last shaping day0.10.10.20.3-0.4-0.40.1