Hub : Genes

Cwc27

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Cwc27 0.09 0.07 1.1e-04 0.04 -0 0.04 0.05 1.6e-04 5.6e-01 1.7e-04 9.1e-05
2 BLA gene expression Cwc27 0.05 0.04 1.5e-03 0.03 0.03 0.02 0.02 8.1e-03 1.3e-02 2.4e-02 4.5e-02
3 RMTg alternative polyA NM_001013199.1 0.09 0.08 9.2e-03 0.06 0.05 0.05 0.05 1.1e-02 1.5e-02 2.1e-02 2.1e-02
4 RMTg alternative polyA XM_017590950.3 0.09 0.08 7.1e-03 0.07 0.06 0.06 0.06 7.3e-03 8.8e-03 1.3e-02 1.1e-02
5 PL gene expression Cwc27 0.05 0.04 9.4e-08 0.05 0.01 0.05 0.01 1.3e-06 2.8e-02 2.7e-06 4.7e-02
6 NAcc gene expression Cwc27 0.01 0.01 2.8e-03 0.01 0.01 0.01 0.01 6.4e-03 2.1e-03 4.4e-03 4.0e-03
7 Brain gene expression Cwc27 0.06 0.04 2.1e-06 0.03 0.06 0.06 0.05 4.1e-04 4.6e-06 4.7e-06 1.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.61.01.3-1.1-0.6-1.01.0-0.9-1.1-1.1
Area under the delay curve0.20.30.50.40.40.7-0.70.50.40.3
BMI with tail2.17.29.1-2.4-2.6-2.62.6-2.6-2.9-3.0
BMI without tail0.51.52.3-0.9-1.0-1.21.2-1.2-1.4-1.5
Body weight3.716.219.34.44.14.1-4.14.13.73.6
Weight adjusted by age0.00.10.20.20.50.2-0.20.20.10.1
Bone surface0.10.10.70.10.80.1-0.10.10.10.1
Bone volume0.00.10.2-0.10.4-0.20.2-0.1-0.2-0.2
Breakpoint value in progressive ratio session3.23.84.1-1.9-2.0-2.02.0-1.7-2.0-2.0
Number of licking bursts2.13.44.3-1.7-2.1-1.81.8-1.9-1.8-1.8
Context. condit. distance diff. score2.02.43.01.61.71.5-1.51.51.51.5
Locomotion velocity, session 10.50.60.90.70.90.7-0.70.80.70.7
Locomotion distance, session 10.70.90.90.90.81.0-1.01.00.90.9
Locomotion velocity, session 24.45.16.02.32.42.2-2.22.32.22.1
Locomotion distance, session 20.91.21.31.11.11.1-1.11.11.01.0
Locomotion velocity, session 35.66.47.22.72.52.6-2.62.62.42.4
Locomotion distance, session 37.98.69.33.02.83.0-3.02.92.92.9
Stereotopy head waving bouts, day 30.10.10.30.40.50.4-0.40.40.30.3
Stereotopy head waving duration, day 30.00.10.1-0.1-0.1-0.20.2-0.2-0.3-0.4
Locomotion velocity, session 70.10.10.20.40.40.4-0.40.30.30.3
Locomotion distance, session 70.50.61.00.71.00.7-0.70.60.70.7
Stereotopy head waving bouts, day 70.00.00.00.00.20.0-0.00.1-0.1-0.1
Stereotopy head waving duration, day 70.10.10.10.30.30.3-0.30.30.20.1
Locomotion velocity, session 82.53.13.51.91.71.8-1.81.81.71.6
Locomotion distance, session 84.97.17.92.72.82.7-2.72.62.62.6
Degree of sensitization distance4.14.24.9-2.2-1.8-2.12.1-2.1-2.0-2.0
Degree of sensitization stereotypy0.00.00.0-0.10.1-0.00.00.0-0.1-0.2
Conditioned locomotion0.00.00.00.0-0.1-0.00.00.00.10.2
Cocaine response after cond. corrected1.61.92.51.41.31.2-1.21.41.51.6
Cocaine response after cond. not corrected2.02.42.91.61.31.4-1.41.71.71.7
Cocaine response before conditioning0.20.20.40.60.20.5-0.50.60.40.3
Saline control response1.52.02.51.51.61.4-1.41.41.31.3
Bone: connectivity density0.10.10.2-0.20.3-0.30.3-0.3-0.4-0.5
Bone: cortical apparent density0.00.00.00.1-0.1-0.00.0-0.0-0.0-0.0
Bone: cortical area0.10.10.30.50.40.3-0.30.50.30.3
Bone: cortical porosity2.22.43.2-1.7-1.8-1.51.5-1.5-1.5-1.4
Bone: cortical porosity2.22.43.1-1.6-1.8-1.51.5-1.5-1.5-1.4
Bone: cortical thickness0.00.00.10.2-0.10.2-0.20.30.0-0.0
Bone: cortical thickness1.11.31.71.31.11.1-1.11.31.11.0
Bone: cortical tissue density0.00.00.00.1-0.0-0.00.00.00.0-0.0
Condit. Reinf. active minus inactive responses2.42.72.9-1.6-1.6-1.71.7-1.7-1.6-1.7
Condit. Reinf. active-inactive response ratio2.42.62.8-1.6-1.4-1.71.7-1.6-1.6-1.6
Condit. Reinf. active responses0.40.50.6-0.7-0.5-0.70.7-0.7-0.7-0.8
Condit. Reinf. inactive responses1.21.51.71.31.21.3-1.31.21.11.1
Incentive salience index mean1.62.02.2-1.5-1.3-1.41.4-1.4-1.4-1.4
Condit. Reinf. lever presses0.20.30.5-0.7-0.4-0.60.6-0.6-0.5-0.5
Condit. Reinf. active minus inactive responses4.86.27.12.72.22.6-2.62.62.42.4
Condit. Reinf. active-inactive response ratio2.22.53.01.71.01.7-1.71.71.61.7
Condit. Reinf. active responses1.82.52.81.71.51.6-1.61.71.51.4
Condit. Reinf. inactive responses0.20.31.10.51.00.5-0.50.40.30.2
Condit. Reinf. lever presses1.82.42.91.71.31.6-1.61.71.51.4
Condit. Reinf. lever reinforcers received2.43.33.71.91.81.9-1.91.91.71.6
Conditioned reinforcement - actives1.93.34.92.22.01.7-1.71.81.71.7
Conditioned reinforcement - inactives0.71.01.31.11.10.9-0.90.91.11.1
Conditioned locomotion0.60.81.41.20.90.8-0.81.00.90.9
Patch foraging indifference point 0 sec3.36.17.32.52.72.4-2.42.32.52.4
Patch foraging indifference point AUC0.20.30.5-0.6-0.4-0.50.5-0.6-0.7-0.7
Delay disc. indifference point, 0s delay0.30.30.4-0.6-0.7-0.40.4-0.6-0.6-0.6
Delay disc. indifference point, 16s delay1.31.52.01.11.21.4-1.41.11.11.1
Delay disc. indifference point, 2s delay0.20.30.6-0.8-0.4-0.40.4-0.5-0.5-0.6
Delay disc. indifference point, 24s delay1.01.11.31.01.21.2-1.21.01.01.0
Delay disc. indifference point, 4s delay0.00.10.2-0.2-0.4-0.00.0-0.2-0.2-0.2
Delay disc. indifference point, 8s delay0.10.10.20.10.20.5-0.50.30.10.0
Indifference point function ln k2.95.05.42.12.32.2-2.22.12.32.3
Indifference point function log k2.95.05.42.12.32.2-2.22.12.32.3
Patch foraging total patch changes 0 sec4.07.58.82.83.02.7-2.72.62.72.7
Patch foraging total patch changes 12 sec0.00.00.3-0.10.50.0-0.0-0.00.20.1
Patch foraging total patch changes 18 sec0.00.00.20.10.40.1-0.1-0.10.0-0.0
Patch foraging total patch changes 24 sec0.71.21.50.91.21.2-1.21.01.21.2
Patch foraging total patch changes 6 sec0.61.01.80.91.31.0-1.00.81.00.9
Patch foraging time to switch 0 sec4.49.110.0-3.2-3.1-3.03.0-3.0-2.9-2.9
Patch foraging water rate 0 sec3.37.07.22.62.72.7-2.72.62.62.6
Patch foraging water rate 12 sec3.36.87.72.52.52.5-2.52.72.72.8
Patch foraging water rate 18 sec4.77.39.12.72.52.5-2.53.02.82.8
Patch foraging water rate 24 sec2.83.94.22.02.01.9-1.92.02.02.0
Patch foraging water rate 6 sec13.419.521.14.34.34.6-4.64.34.44.4
Seeking ratio, delayed vs. immediate footshock0.91.11.5-1.0-0.8-1.01.0-1.1-1.2-1.2
Distance traveled before self-admin0.70.91.30.91.10.8-0.80.91.01.0
Distance traveled after self-admin1.62.02.41.21.51.5-1.51.41.41.4
Extensor digitorum longus weight3.815.018.4-3.7-3.5-3.83.8-3.9-4.2-4.3
Bone: elastic displacement1.92.23.2-1.6-1.8-1.41.4-1.5-1.4-1.4
Bone: elastic work0.50.61.0-0.9-1.0-0.70.7-0.8-0.7-0.7
Bone: endosteal estimation0.61.21.61.01.21.0-1.01.01.21.3
Bone: endosteal perimeter0.00.10.40.30.60.2-0.20.20.30.3
Epididymis fat weight0.82.63.41.71.71.6-1.61.81.51.4
Delta time in closed arm before/after self-admin3.43.23.3-1.8-1.7-1.81.8-1.8-1.8-1.8
Delta time in open arm before/after self-admin0.20.20.2-0.4-0.4-0.40.4-0.3-0.4-0.4
Diff in mean of infusions in LGA sessions0.10.10.20.40.40.2-0.20.30.10.1
Delay discount exponential model param0.20.30.5-0.4-0.4-0.70.7-0.5-0.4-0.3
Extinction: sum of active levers before priming2.93.23.7-1.8-1.9-1.71.7-1.7-1.8-1.8
Active lever presses in extinction session 62.52.52.7-1.6-1.5-1.61.6-1.5-1.6-1.6
Bone: final force0.40.70.80.80.70.9-0.90.90.80.9
Bone: final moment0.61.01.11.00.91.0-1.01.11.01.1
Food consumed during 24 hour testing period0.70.91.20.90.61.0-1.01.01.01.1
Glucose0.50.71.4-0.8-1.2-0.90.9-0.8-0.7-0.6
Heart weight0.71.01.31.11.01.0-1.00.91.01.0
Delay discount hyperbolic model param0.20.20.4-0.3-0.4-0.70.7-0.5-0.3-0.3
Intermittent access intake day 1-15 change0.00.00.0-0.0-0.1-0.10.1-0.2-0.1-0.0
Intermittent access intake escalation0.00.10.10.30.20.2-0.20.20.30.4
Intermittent access intake escalation 20.10.20.3-0.2-0.4-0.40.4-0.5-0.4-0.4
Intermitt. access day 1 inactive lever presses0.41.72.1-1.2-0.9-1.41.4-1.4-1.3-1.3
Intermitt. access day 15 inactive lever presses0.71.51.9-1.2-1.4-1.31.3-1.2-1.1-1.1
Intermitt. access escalation Index0.50.70.80.80.80.9-0.90.90.80.8
Intermittent access day 1 total infusions1.72.73.81.82.01.5-1.51.51.51.5
Intermittent access day 15 total infusions2.33.54.32.12.11.7-1.71.71.91.9
Intermittent access terminal intake (last 3 days)1.72.23.01.71.71.4-1.41.31.41.4
Intermittent access total infusions3.54.15.12.22.21.9-1.91.92.02.0
Intermittent access day 1 locomotion2.83.54.62.12.01.7-1.71.71.91.9
Intermittent access day 15 total locomotion2.13.85.22.32.01.8-1.81.82.02.0
Intermittent access total locomotion5.46.48.22.92.62.5-2.52.32.52.6
Intermittent access standard deviation0.00.00.0-0.0-0.1-0.10.1-0.20.00.1
Left kidney weight2.712.413.83.63.73.6-3.63.63.43.3
Right kidney weight2.611.814.53.63.83.4-3.43.53.23.1
Cocaine induced anxiety0.71.01.21.00.91.0-1.01.01.01.1
Post-drug Anxiety0.50.50.70.80.80.6-0.60.80.80.8
Baseline Anxiety0.20.30.5-0.4-0.2-0.70.7-0.4-0.5-0.6
Tail length9.838.341.36.46.46.0-6.06.16.26.1
Length with tail15.467.072.38.58.48.1-8.18.38.07.9
Length without tail11.135.738.46.15.96.1-6.16.25.85.7
Times rat made contact with spout0.40.50.7-0.7-0.9-0.70.7-0.6-0.5-0.5
Lifetime Intake2.83.54.12.02.01.8-1.81.71.81.8
Liver weight, left4.57.58.72.82.92.8-2.82.72.62.6
Liver weight, right0.00.10.30.30.50.3-0.30.00.0-0.1
Locomotor activity0.30.50.90.80.90.5-0.50.70.70.7
Locomotor testing distance0.20.30.5-0.5-0.4-0.60.6-0.7-0.6-0.6
Locomotor testing rearing0.10.20.4-0.1-0.2-0.60.6-0.6-0.3-0.3
Locomotion in novel chamber0.50.61.3-1.2-0.4-0.80.8-1.0-0.6-0.5
Locomotion in novel chamber post-restriction0.00.10.4-0.0-0.6-0.10.1-0.3-0.1-0.1
Fecal boli incidents, locomotor time 10.91.31.5-1.0-1.1-1.21.2-1.2-1.2-1.1
Change in fecal boli incidents, locomotor task0.10.10.2-0.40.3-0.30.3-0.3-0.1-0.2
Time >=10cm from walls, locomotor time 11.81.92.7-1.2-1.1-1.31.3-1.7-1.5-1.5
Bouts of movement, locomotor time 10.30.30.4-0.5-0.7-0.50.5-0.6-0.4-0.4
Total resting periods, locomotor time 10.00.00.0-0.0-0.2-0.10.1-0.20.00.1
Rest time, locomotor task time 10.70.82.0-0.8-1.4-0.90.9-0.8-0.7-0.6
Distance moved, locomotor task time 11.01.52.61.11.61.3-1.31.11.01.0
Vertical activity count, locomotor time 10.41.02.00.81.40.9-0.90.90.90.9
Time >=10cm from walls, locomotor time 20.81.11.7-1.2-0.8-0.80.8-1.3-1.2-1.2
Bouts of movement, locomotor time 20.10.20.40.60.20.5-0.50.50.40.3
Total resting periods, locomotor time 20.00.00.10.2-0.30.0-0.00.0-0.1-0.1
Rest time, locomotor task time 23.34.15.6-1.9-2.2-2.42.4-1.7-1.8-1.7
Distance moved, locomotor task time 21.82.13.21.51.51.8-1.81.31.21.1
Vertical activity count, locomotor time 20.20.30.60.30.50.7-0.70.30.40.4
Light reinforcement 12.04.87.32.42.72.1-2.11.92.12.0
Light reinforcement 20.10.20.4-0.2-0.5-0.60.6-0.4-0.4-0.4
Bone: marrow area0.51.21.61.01.21.0-1.01.01.21.3
Bone: maximum diameter0.20.30.5-0.5-0.4-0.60.6-0.5-0.6-0.7
Bone: maximum force0.10.20.30.40.30.5-0.50.50.40.5
Bone: maximum moment0.30.50.60.70.60.8-0.80.80.70.7
Mean time between licks in bursts0.20.40.9-0.6-0.9-0.60.6-0.6-0.7-0.6
Mean num. licks in bursts1.42.22.61.31.61.4-1.41.51.51.6
Cd content in liver1.31.51.91.41.21.3-1.31.31.11.1
Co content in liver0.00.00.1-0.1-0.2-0.10.1-0.1-0.2-0.2
Cu content in liver0.00.00.00.1-0.00.2-0.20.10.10.2
Fe content in liver1.11.41.51.21.11.2-1.21.21.11.1
K content in liver2.01.92.21.31.21.4-1.41.31.41.5
Mg content in liver0.10.10.20.20.30.3-0.30.30.40.4
Mn content in liver0.50.60.60.80.80.7-0.70.80.80.8
Na content in liver0.00.00.0-0.1-0.1-0.10.1-0.1-0.0-0.0
Rb content in liver1.41.61.91.31.01.4-1.41.41.21.2
Se content in liver0.80.91.0-1.0-0.7-1.01.0-1.0-1.0-1.0
Sr content in liver2.32.02.3-1.4-1.5-1.41.4-1.4-1.4-1.4
Zn content in liver0.20.20.30.40.50.4-0.40.40.50.5
Bone: minimum diameter2.54.55.12.02.32.0-2.02.22.22.2
Time in familiar zone, hab. session 14.64.54.72.12.12.2-2.22.12.12.1
Time in novel zone, hab. session 16.66.66.8-2.6-2.5-2.62.6-2.5-2.6-2.6
Total zone transitions, hab. session 10.00.00.10.10.30.2-0.20.20.0-0.0
Total locomotion distance, hab. session 10.20.30.40.60.30.6-0.60.60.50.5
Locomotion velocity, hab. session 10.20.30.30.60.30.5-0.50.60.50.5
Time in familiar zone, hab. session 22.42.53.31.61.81.5-1.51.51.61.6
Time in novel zone, hab. session 23.03.04.3-1.7-2.1-1.61.6-1.6-1.8-1.8
Total zone transitions, hab. session 20.10.20.20.40.20.5-0.50.50.40.4
Total locomotion distance, hab. session 20.00.10.20.2-0.40.2-0.20.20.10.2
Locomotion velocity, hab. session 20.20.20.30.50.00.5-0.50.50.50.5
Novel to familiar place preference ratio2.42.73.0-1.7-1.6-1.51.5-1.6-1.7-1.7
Novelty place preference1.92.02.4-1.4-1.3-1.31.3-1.4-1.5-1.5
Time in novel zone, NPP test2.02.22.6-1.5-1.4-1.41.4-1.5-1.6-1.6
Total zone transitions, NPP test1.42.02.31.51.11.5-1.51.51.41.4
Total locomotion distance, NPP test0.20.30.40.60.00.6-0.60.60.50.5
Locomotion velocity, NPP test0.81.11.41.10.61.1-1.11.21.11.1
Intraocular pressure4.26.17.5-2.2-2.5-2.42.4-2.3-2.7-2.7
Delta distance traveled before/after self-admin1.61.72.31.11.21.5-1.51.21.21.2
Delta ambulatory time before/after self-admin1.31.72.21.11.41.5-1.51.11.21.2
Parametrial fat weight0.00.10.20.40.30.3-0.30.1-0.0-0.1
Pavlov. Cond. lever latency0.00.00.0-0.1-0.2-0.10.1-0.1-0.1-0.1
Pavlov. Cond. magazine entry latency1.92.42.61.61.61.6-1.61.51.51.4
Pavlov. Cond. change in total contacts3.23.43.61.91.91.9-1.91.81.81.7
Pavlov. Cond. index score0.60.81.00.91.00.9-0.90.90.90.8
Pavlov. Cond. latency score0.20.30.40.50.60.5-0.50.50.50.5
Pavlov. Cond. lever contacts0.60.70.80.90.90.9-0.90.90.90.8
Pavlov. Cond. magazine entry number3.13.94.2-2.0-2.0-2.02.0-2.0-1.9-1.9
Pavlov. Cond. intertrial magazine entries6.78.09.2-2.6-2.9-2.82.8-2.7-3.0-3.0
Pavlov. Cond. lever-magazine prob. diff.0.91.11.31.01.11.0-1.01.01.01.0
Pavlov. Cond. response bias2.83.53.81.92.01.9-1.91.81.81.7
Pavlov. Cond. lever latency2.53.43.6-1.9-1.9-1.91.9-1.9-1.8-1.8
Pavlov. Cond. magazine entry latency1.21.51.71.31.31.1-1.11.21.21.2
Pavlov. Cond. change in total contacts4.57.38.42.72.92.6-2.62.72.72.6
Pavlov. Cond. index score2.63.53.81.91.91.8-1.81.91.91.8
Pavlov. Cond. latency score2.63.43.81.91.91.8-1.81.91.91.8
Pavlov. Cond. lever contacts1.82.52.81.61.71.6-1.61.61.51.5
Pavlov. Cond. magazine entry number2.43.03.3-1.8-1.8-1.61.6-1.8-1.8-1.8
Pavlov. Cond. intertrial magazine entries0.00.10.10.30.10.4-0.40.20.10.1
Pavlov. Cond. lever-magazine prob. diff.2.73.64.02.02.01.8-1.81.91.91.9
Pavlov. Cond. response bias1.62.12.31.51.51.4-1.41.51.41.4
Time in closed arm before self-admin0.40.50.80.70.90.5-0.50.70.70.7
Time in closed arm after self-admin0.00.00.00.10.20.0-0.00.00.00.1
Time in open arm before self-admin0.10.10.30.30.10.5-0.50.10.10.1
Time in open arm after self-admin1.01.01.5-1.0-1.2-0.90.9-1.0-1.0-1.0
Bone: periosteal estimation0.30.70.80.90.90.7-0.70.80.90.9
Bone: periosteal perimeter0.10.20.40.50.60.4-0.40.50.40.3
Bone: post-yield work0.10.20.30.50.40.5-0.50.50.30.2
Progressive ratio test 1 active lever presses2.73.44.71.92.21.8-1.81.61.81.7
Progressive ratio test 1 breakpoint3.03.75.12.02.31.9-1.91.71.81.8
Progressive ratio test 1 inactive lever presses0.71.01.71.01.30.9-0.90.81.01.0
Progressive ratio test 2 active lever presses2.73.24.52.11.91.6-1.61.71.71.8
Progressive ratio test 2 breakpoint3.03.44.72.22.01.7-1.71.71.81.8
Progressive ratio test 2 inactive lever presses0.71.11.71.31.30.9-0.90.91.01.0
Incentive Sensitization - Responses2.43.44.82.21.71.6-1.61.91.91.9
Incentive Sensitization - Breakpoint2.12.74.02.01.61.5-1.51.71.71.7
Sum of active levers in priming session hrs 5-62.32.12.6-1.4-1.6-1.51.5-1.2-1.4-1.5
Progressive ratio0.10.10.30.6-0.20.3-0.30.30.0-0.0
Food seeking constrained by brief footshock2.32.83.51.51.41.7-1.71.71.81.9
Seeking ratio, punishment vs. effort0.71.01.70.61.10.8-0.80.91.21.3
Retroperitoneal fat weight0.10.31.10.51.10.5-0.50.60.30.2
Reaction time number correct7.414.215.94.03.63.8-3.83.83.73.7
Reaction time mean minus median0.00.00.10.30.20.2-0.20.20.20.1
Reaction time mean minus median AUC0.10.30.60.80.30.5-0.50.70.60.6
Reaction time num false alarms0.60.81.5-0.7-1.2-0.80.8-0.9-0.9-0.9
Reaction time num false alarms AUC1.01.62.6-0.9-1.6-1.21.2-1.2-1.3-1.3
Reaction time trials correct on left7.414.215.94.03.63.8-3.83.83.73.7
Reaction time trials on left7.614.216.14.03.63.8-3.83.83.73.7
Reaction time mean1.72.63.5-1.6-1.9-1.51.5-1.5-1.7-1.7
Reaction time mean AUC1.42.23.4-1.4-1.8-1.41.4-1.3-1.6-1.6
Median of all reaction times3.14.45.9-2.1-2.4-1.91.9-1.9-2.2-2.2
Reaction time omissions0.20.30.50.70.20.4-0.40.60.50.5
Reaction time false alarm rate6.79.210.5-2.9-3.2-3.03.0-3.0-3.0-3.1
Reaction time premature initiation rate3.85.26.22.32.22.1-2.12.32.42.5
Reaction time premature initiations9.516.918.54.34.03.9-3.94.14.24.2
Std. dev. reaction times0.10.20.4-0.3-0.6-0.50.5-0.4-0.5-0.5
Reaction time trials completed7.614.216.14.03.63.8-3.83.83.73.7
Reaction time trials AUC6.712.914.63.83.43.6-3.63.63.53.5
Run reversals in cocaine runway, females0.60.60.8-0.9-0.7-0.70.7-0.6-0.9-0.9
Run reversals in cocaine runway, males0.10.10.30.50.30.3-0.30.50.20.2
Latency to leave start box in cocaine runway2.22.53.7-1.4-1.9-1.61.6-1.5-1.6-1.5
Latency to leave start box in cocaine runway, F0.30.30.7-0.4-0.9-0.50.5-0.4-0.5-0.4
Latency to leave start box in cocaine runway, M2.12.02.1-1.4-1.4-1.41.4-1.3-1.5-1.5
Std. dev. time between licks in bursts0.50.60.7-0.8-0.9-0.80.8-0.8-0.8-0.7
Total sessions with >9 infusions0.91.01.31.11.11.0-1.01.00.90.9
Short access day 1 total inactive lever presses0.81.11.31.01.11.1-1.11.01.01.0
Short access day 10 total inactive lever presses0.20.40.6-0.4-0.6-0.80.8-0.6-0.6-0.6
Short access day 1 total infusions0.40.60.70.80.80.8-0.80.70.70.7
Short access day 10 total infusions1.92.42.91.71.61.6-1.61.41.41.4
Short access total infusions1.41.72.11.31.51.4-1.41.21.21.2
Short access day 1 locomotion0.10.10.30.60.20.3-0.30.30.30.3
Short access day 10 total locomotion0.30.60.7-0.5-0.7-0.80.8-0.8-0.8-0.7
Short access total locomotion0.50.60.80.90.70.8-0.80.70.70.7
One hour access (0.3 mA shock)2.73.24.92.22.11.7-1.71.61.61.5
Compulsive drug intake1.82.12.4-1.2-1.5-1.51.5-1.3-1.5-1.6
One hour access (shock baseline)3.85.86.62.52.62.4-2.42.22.42.4
Social response proportion0.10.10.20.2-0.0-0.50.5-0.1-0.3-0.4
Social responses1.72.24.11.72.01.2-1.21.41.31.2
Social time0.00.00.10.00.1-0.30.3-0.0-0.1-0.1
Soleus weight0.20.71.1-0.7-0.5-0.80.8-0.9-1.0-1.0
Bone: stiffness0.20.40.50.60.50.6-0.60.70.60.5
Tibialis anterior weight2.58.69.7-2.9-2.7-2.92.9-3.0-3.1-3.1
Time to tail flick, vehicle, before self-admin2.12.22.41.51.41.5-1.51.41.41.5
Time to tail flick, vehicle, after self-admin0.00.00.1-0.1-0.0-0.30.30.10.10.1
Time to tail flick, test, before self-admin0.20.20.4-0.4-0.6-0.30.3-0.4-0.4-0.3
Time to tail flick, test, after self-admin1.41.51.9-1.4-1.3-1.21.2-1.2-1.1-1.0
Delta time to tail flick, vehicle, before/after SA1.71.72.2-1.2-1.4-1.51.5-1.1-1.1-1.1
Delta time to tail flick, test, before/after SA0.00.00.0-0.20.1-0.10.10.00.00.0
Tibia length6.417.618.14.24.04.3-4.34.24.24.2
Ambulatory time before self-admin0.10.10.20.40.30.4-0.40.40.40.4
Ambulatory time after self-admin1.31.52.01.01.31.4-1.41.11.21.2
Bone: tissue strength0.90.91.3-1.0-1.2-0.90.9-0.9-0.9-0.9
Total heroin consumption1.31.62.0-1.1-1.1-1.41.4-1.3-1.1-1.1
Bone: trabecular number0.00.00.20.00.40.1-0.10.0-0.1-0.2
Bone: trabecular spacing0.10.20.3-0.5-0.2-0.50.5-0.5-0.3-0.3
Bone: trabecular thickness0.70.81.0-0.7-0.9-0.90.9-0.8-1.0-1.0
Bone: trabecular tissue density2.94.37.2-2.1-2.7-2.02.0-1.9-1.9-1.8
Water consumed over 24 hours0.50.71.0-0.9-1.0-0.80.8-0.8-0.7-0.7
Number of responses in last shaping day0.50.60.9-0.8-0.5-0.70.7-1.0-0.7-0.7