Hub : Genes

Cwc25

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression Cwc25 0.73 0.21 2.8e-03 0.01 0.05 -0 -0.01 2.1e-01 6.6e-02 3.8e-01 5.2e-01
2 BLA gene expression Cwc25 0.07 0.05 9.1e-04 0.03 0.03 0.03 0.03 1.2e-02 1.0e-02 1.8e-02 1.5e-02
3 Brain mRNA stability Cwc25 0.05 0.04 5.9e-06 0.06 0.06 0.05 0.06 4.0e-06 3.2e-06 8.7e-06 5.4e-06
4 pVTA gene expression Cwc25 0.28 0.15 5.6e-17 0.19 0.19 0.19 0.19 1.6e-15 1.5e-15 5.7e-15 2.9e-15
5 PL gene expression Cwc25 0.05 0.03 3.4e-07 0.07 0.06 0.06 0.06 4.2e-08 2.2e-07 1.4e-07 1.3e-07
6 Liver mRNA stability Cwc25 0.08 0.06 5.0e-09 0.07 0.07 0.06 0.06 8.3e-08 7.5e-08 2.6e-07 1.5e-07
7 LHb gene expression Cwc25 0.24 0.16 2.1e-04 0.11 0.05 0.16 0.06 1.7e-03 2.9e-02 1.3e-04 1.9e-02
8 Liver gene expression Cwc25 0.2 0.12 0.0e+00 0.2 0.2 0.2 0.2 2.3e-21 3.7e-22 1.3e-21 7.9e-22
9 Brain gene expression Cwc25 0.14 0.11 2.7e-06 0.06 0.06 0.06 0.05 6.3e-06 1.8e-06 2.1e-06 7.9e-06
10 NAcc gene expression Cwc25 0.17 0.1 8.2e-09 0.06 0.06 0.06 0.06 2.9e-09 5.0e-10 4.6e-10 3.2e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density1.62.83.81.9-1.9-1.8-1.8-1.6-1.7-1.6-1.6-1.3-1.2
Area under the delay curve1.21.43.20.8-1.1-1.0-1.1-0.9-1.2-1.2-1.4-1.8-1.2
BMI with tail1.96.516.1-1.82.42.11.92.52.72.33.24.01.7
BMI without tail1.44.45.2-2.22.32.12.02.12.22.02.32.21.3
Body weight7.030.834.2-5.85.85.85.55.55.75.65.65.34.7
Weight adjusted by age0.10.20.7-0.40.40.40.60.50.40.40.30.20.8
Bone surface0.00.00.2-0.10.10.10.10.00.10.20.10.10.4
Bone volume0.00.10.10.3-0.3-0.3-0.2-0.2-0.3-0.1-0.3-0.20.1
Breakpoint value in progressive ratio session1.72.03.1-1.81.61.61.51.51.41.41.31.01.1
Number of licking bursts0.40.60.90.9-0.8-0.8-0.7-0.9-0.8-0.8-0.7-0.7-0.6
Context. condit. distance diff. score0.40.40.6-0.70.70.70.70.80.60.50.60.50.7
Locomotion velocity, session 11.31.41.8-1.21.11.21.31.11.21.31.11.01.3
Locomotion distance, session 13.94.96.3-2.52.42.42.32.32.22.22.11.81.8
Locomotion velocity, session 20.81.01.2-1.01.01.01.11.01.01.10.90.81.0
Locomotion distance, session 21.11.61.8-1.41.31.31.31.31.21.31.21.01.1
Locomotion velocity, session 30.10.20.2-0.50.50.50.40.20.40.50.40.40.4
Locomotion distance, session 30.60.60.8-0.80.80.80.80.60.80.80.80.70.9
Stereotopy head waving bouts, day 33.64.35.02.2-2.2-2.2-2.2-2.2-2.1-2.0-2.0-1.7-1.9
Stereotopy head waving duration, day 30.70.81.00.9-0.9-0.9-0.9-1.0-0.9-0.8-0.9-0.8-0.9
Locomotion velocity, session 70.60.61.0-1.00.90.90.80.70.80.60.80.60.5
Locomotion distance, session 70.00.00.1-0.30.30.20.10.20.2-0.00.20.2-0.0
Stereotopy head waving bouts, day 71.11.21.81.3-1.3-1.2-1.1-1.3-1.1-0.9-1.1-0.9-0.5
Stereotopy head waving duration, day 70.20.20.40.6-0.7-0.5-0.4-0.7-0.5-0.2-0.5-0.40.0
Locomotion velocity, session 86.37.59.5-3.12.92.92.92.82.82.72.62.22.4
Locomotion distance, session 81.82.63.0-1.71.71.71.71.61.61.61.51.31.6
Degree of sensitization distance0.10.10.3-0.40.40.40.30.50.30.20.30.30.1
Degree of sensitization stereotypy1.61.72.31.5-1.5-1.4-1.3-1.5-1.3-1.1-1.3-1.1-0.8
Conditioned locomotion0.20.30.30.5-0.5-0.5-0.6-0.6-0.5-0.5-0.5-0.4-0.5
Cocaine response after cond. corrected1.72.03.21.8-1.7-1.6-1.4-1.5-1.5-1.4-1.4-1.1-0.6
Cocaine response after cond. not corrected2.83.34.72.2-2.1-2.0-1.9-1.9-1.9-1.7-1.8-1.4-1.1
Cocaine response before conditioning0.91.11.90.9-0.9-1.0-1.2-1.2-1.0-1.0-1.0-0.8-1.4
Saline control response0.10.10.20.2-0.2-0.2-0.3-0.4-0.2-0.3-0.2-0.2-0.5
Bone: connectivity density2.43.74.82.2-2.1-2.1-2.0-2.0-2.0-1.9-1.9-1.6-1.5
Bone: cortical apparent density4.25.87.92.8-2.7-2.6-2.5-2.5-2.4-2.2-2.4-1.9-1.7
Bone: cortical area0.20.30.40.6-0.6-0.6-0.6-0.6-0.5-0.5-0.5-0.4-0.4
Bone: cortical porosity1.01.01.31.1-1.0-1.1-1.1-0.9-1.0-1.1-0.9-0.8-1.1
Bone: cortical porosity1.01.11.41.1-1.0-1.1-1.1-0.8-1.1-1.2-0.9-0.8-1.2
Bone: cortical thickness1.22.03.01.7-1.6-1.6-1.4-1.5-1.4-1.3-1.4-1.1-0.8
Bone: cortical thickness4.65.46.62.6-2.4-2.5-2.5-2.4-2.3-2.4-2.2-1.9-2.0
Bone: cortical tissue density4.25.77.92.8-2.7-2.6-2.5-2.5-2.4-2.2-2.3-1.9-1.7
Condit. Reinf. active minus inactive responses0.40.40.50.7-0.7-0.7-0.7-0.6-0.7-0.7-0.6-0.6-0.7
Condit. Reinf. active-inactive response ratio0.90.91.40.9-0.9-1.0-1.0-0.8-0.9-1.1-0.9-0.8-1.2
Condit. Reinf. active responses0.50.70.90.9-0.9-0.9-0.9-0.7-0.8-0.8-0.8-0.7-0.6
Condit. Reinf. inactive responses0.40.50.80.9-0.8-0.8-0.7-0.6-0.7-0.7-0.7-0.5-0.4
Incentive salience index mean1.21.51.71.3-1.3-1.3-1.3-1.1-1.2-1.3-1.2-1.0-1.2
Condit. Reinf. lever presses1.21.61.91.4-1.3-1.4-1.4-1.1-1.3-1.4-1.2-1.0-1.3
Condit. Reinf. active minus inactive responses0.60.81.10.9-0.9-0.9-0.9-1.0-0.9-0.9-0.8-0.7-0.9
Condit. Reinf. active-inactive response ratio0.30.30.40.7-0.6-0.6-0.5-0.6-0.5-0.5-0.5-0.4-0.3
Condit. Reinf. active responses1.01.42.01.2-1.1-1.2-1.2-1.4-1.2-1.3-1.1-0.9-1.4
Condit. Reinf. inactive responses2.02.64.01.6-1.5-1.6-1.8-1.7-1.6-1.7-1.5-1.3-2.0
Condit. Reinf. lever presses0.00.00.20.1-0.1-0.1-0.1-0.4-0.1-0.2-0.1-0.1-0.3
Condit. Reinf. lever reinforcers received1.01.41.91.2-1.1-1.2-1.2-1.3-1.1-1.2-1.0-0.9-1.4
Conditioned reinforcement - actives0.81.42.50.9-0.9-1.1-1.3-1.2-1.2-1.4-1.1-1.1-1.6
Conditioned reinforcement - inactives0.10.10.60.1-0.1-0.2-0.3-0.1-0.3-0.5-0.2-0.4-0.8
Conditioned locomotion1.41.92.61.5-1.4-1.5-1.5-1.2-1.4-1.6-1.2-1.0-1.2
Patch foraging indifference point 0 sec1.22.22.81.4-1.5-1.5-1.5-1.7-1.5-1.5-1.5-1.4-1.4
Patch foraging indifference point AUC0.10.10.5-0.00.10.20.30.30.30.50.20.40.7
Delay disc. indifference point, 0s delay1.92.13.71.3-1.4-1.4-1.3-1.3-1.5-1.4-1.6-1.9-1.2
Delay disc. indifference point, 16s delay0.60.71.20.7-0.8-0.8-0.7-0.8-0.9-0.8-1.0-1.1-0.5
Delay disc. indifference point, 2s delay2.83.15.31.4-1.7-1.6-1.6-1.5-1.8-1.7-2.0-2.3-1.7
Delay disc. indifference point, 24s delay0.00.00.20.0-0.2-0.0-0.0-0.2-0.10.2-0.3-0.4-0.1
Delay disc. indifference point, 4s delay0.70.73.30.4-0.7-0.5-0.3-0.4-0.8-0.7-1.2-1.8-0.2
Delay disc. indifference point, 8s delay0.91.01.80.7-0.8-0.9-1.0-0.7-1.0-1.1-1.1-1.3-1.2
Indifference point function ln k0.00.10.30.0-0.1-0.1-0.2-0.3-0.2-0.3-0.2-0.4-0.5
Indifference point function log k0.00.10.30.0-0.1-0.1-0.2-0.3-0.2-0.3-0.2-0.4-0.5
Patch foraging total patch changes 0 sec0.71.31.71.1-1.1-1.1-1.1-1.3-1.1-1.1-1.1-1.1-1.1
Patch foraging total patch changes 12 sec3.74.85.42.3-2.3-2.3-2.2-2.3-2.3-2.1-2.3-2.1-1.7
Patch foraging total patch changes 18 sec0.10.20.50.7-0.6-0.5-0.4-0.3-0.4-0.1-0.30.20.2
Patch foraging total patch changes 24 sec0.81.42.41.6-1.5-1.4-1.2-1.1-1.3-1.0-1.2-1.0-0.5
Patch foraging total patch changes 6 sec0.71.11.61.3-1.2-1.1-1.0-1.1-1.0-0.8-1.0-0.8-0.6
Patch foraging time to switch 0 sec0.00.00.10.2-0.2-0.2-0.2-0.0-0.2-0.3-0.1-0.0-0.0
Patch foraging water rate 0 sec0.00.00.1-0.0-0.1-0.0-0.0-0.3-0.00.1-0.1-0.1-0.1
Patch foraging water rate 12 sec0.20.50.8-0.90.70.80.90.70.60.70.50.20.7
Patch foraging water rate 18 sec0.71.12.90.5-0.8-0.7-0.8-0.8-1.0-1.1-1.2-1.7-1.3
Patch foraging water rate 24 sec0.40.51.50.5-0.6-0.6-0.7-0.7-0.7-0.7-0.7-0.8-1.2
Patch foraging water rate 6 sec0.81.21.41.0-1.1-1.1-1.1-1.1-1.1-1.0-1.2-1.2-1.1
Seeking ratio, delayed vs. immediate footshock0.20.30.6-0.30.40.40.50.50.60.60.60.80.6
Distance traveled before self-admin0.10.10.3-0.60.50.40.30.40.30.10.40.1-0.2
Distance traveled after self-admin0.60.71.1-1.11.10.90.60.80.90.70.90.9-0.0
Extensor digitorum longus weight8.132.038.3-6.25.96.06.05.75.75.75.44.65.3
Bone: elastic displacement0.00.00.00.2-0.2-0.1-0.0-0.2-0.1-0.1-0.1-0.10.1
Bone: elastic work0.00.00.10.0-0.00.00.0-0.1-0.00.00.00.10.3
Bone: endosteal estimation1.63.55.0-2.22.12.11.91.81.91.81.81.61.3
Bone: endosteal perimeter1.63.44.9-2.22.12.01.81.91.91.81.81.51.2
Epididymis fat weight0.00.10.2-0.50.40.40.20.20.30.30.30.30.1
Delta time in closed arm before/after self-admin4.03.74.1-1.92.02.02.01.82.02.02.01.91.5
Delta time in open arm before/after self-admin0.00.00.10.0-0.1-0.1-0.00.1-0.1-0.1-0.1-0.3-0.1
Diff in mean of infusions in LGA sessions0.10.10.4-0.50.40.3-0.00.20.20.10.20.2-0.6
Delay discount exponential model param0.80.92.5-0.50.80.70.80.71.00.91.21.60.9
Extinction: sum of active levers before priming0.40.40.9-0.90.80.80.60.50.70.70.50.20.0
Active lever presses in extinction session 60.00.00.00.1-0.1-0.1-0.0-0.20.00.1-0.0-0.10.0
Bone: final force1.21.92.41.5-1.4-1.5-1.5-1.4-1.4-1.4-1.3-1.1-1.2
Bone: final moment1.01.62.01.4-1.3-1.4-1.4-1.3-1.3-1.3-1.2-1.0-1.1
Food consumed during 24 hour testing period0.91.21.5-1.11.11.21.20.81.11.21.00.91.1
Glucose0.40.71.40.8-0.9-0.8-0.7-0.9-0.9-0.7-1.0-1.2-0.4
Heart weight3.25.06.1-2.12.22.22.12.42.32.22.42.51.7
Delay discount hyperbolic model param0.80.82.5-0.50.80.70.70.60.90.91.11.60.9
Intermittent access intake day 1-15 change0.10.20.4-0.40.50.30.10.30.40.20.50.6-0.5
Intermittent access intake escalation0.10.10.4-0.30.40.3-0.00.20.30.20.40.6-0.6
Intermittent access intake escalation 20.60.71.6-0.70.80.70.60.80.90.91.01.30.2
Intermitt. access day 1 inactive lever presses0.20.71.80.5-0.6-0.7-0.8-0.6-0.8-0.9-0.8-1.0-1.3
Intermitt. access day 15 inactive lever presses0.30.61.31.1-1.0-1.0-0.8-0.7-0.8-0.8-0.7-0.5-0.3
Intermitt. access escalation Index1.01.41.7-1.11.11.21.30.91.21.31.21.11.3
Intermittent access day 1 total infusions0.00.00.1-0.00.0-0.0-0.1-0.1-0.1-0.2-0.1-0.2-0.3
Intermittent access day 15 total infusions0.10.10.3-0.40.50.30.00.10.30.10.30.3-0.5
Intermittent access terminal intake (last 3 days)0.10.10.60.1-0.0-0.1-0.4-0.2-0.1-0.2-0.00.1-0.8
Intermittent access total infusions0.10.10.1-0.40.40.30.10.20.20.10.20.2-0.3
Intermittent access day 1 locomotion0.20.20.40.3-0.3-0.4-0.4-0.4-0.5-0.6-0.5-0.6-0.6
Intermittent access day 15 total locomotion0.50.91.60.8-0.8-0.9-1.0-1.0-0.9-1.1-0.9-0.9-1.2
Intermittent access total locomotion1.31.51.91.2-1.1-1.2-1.3-1.1-1.2-1.4-1.2-1.2-1.4
Intermittent access standard deviation0.10.21.00.3-0.2-0.3-0.5-0.2-0.3-0.3-0.2-0.0-1.0
Left kidney weight1.25.57.0-2.62.42.52.62.22.42.52.11.72.2
Right kidney weight0.20.71.0-1.00.80.91.00.60.81.00.70.51.0
Cocaine induced anxiety3.24.65.2-2.22.22.22.02.12.22.22.32.31.6
Post-drug Anxiety0.80.81.4-0.91.00.90.70.91.00.81.11.20.2
Baseline Anxiety3.44.04.32.0-2.1-2.0-1.9-2.0-2.0-2.0-2.0-2.0-1.8
Tail length1.87.013.6-3.72.93.23.22.52.42.71.60.12.5
Length with tail4.620.029.8-5.54.95.14.94.34.44.73.82.64.0
Length without tail3.310.611.6-3.43.33.43.43.13.33.43.23.03.0
Times rat made contact with spout0.70.81.21.1-1.1-1.0-0.7-1.1-0.9-0.7-0.8-0.7-0.3
Lifetime Intake0.00.00.2-0.30.20.1-0.10.00.1-0.00.10.1-0.4
Liver weight, left0.20.30.4-0.50.50.50.50.60.50.60.50.40.6
Liver weight, right0.30.41.40.4-0.6-0.5-0.5-0.6-0.7-0.5-0.9-1.2-0.3
Locomotor activity0.50.81.21.1-1.0-1.0-1.0-1.0-0.9-0.9-0.8-0.6-0.7
Locomotor testing distance2.95.26.72.4-2.3-2.4-2.5-2.2-2.2-2.3-2.1-1.8-2.6
Locomotor testing rearing3.67.37.62.7-2.8-2.7-2.7-2.7-2.7-2.6-2.7-2.7-2.7
Locomotion in novel chamber2.63.35.91.9-2.1-1.8-1.2-1.8-1.8-1.5-2.1-2.4-0.7
Locomotion in novel chamber post-restriction0.10.20.50.7-0.5-0.5-0.6-0.6-0.4-0.4-0.20.2-0.3
Fecal boli incidents, locomotor time 10.30.51.2-0.20.40.40.50.70.60.60.81.11.1
Change in fecal boli incidents, locomotor task0.70.71.50.4-0.6-0.6-0.7-0.8-0.8-0.7-0.9-1.2-1.2
Time >=10cm from walls, locomotor time 10.70.80.90.9-0.9-0.9-0.9-0.7-0.9-1.0-0.9-0.8-0.8
Bouts of movement, locomotor time 10.30.40.9-0.70.70.60.50.90.60.40.60.50.3
Total resting periods, locomotor time 10.50.51.0-0.90.90.80.61.00.70.50.70.60.4
Rest time, locomotor task time 10.00.00.1-0.10.20.20.20.30.10.10.20.20.0
Distance moved, locomotor task time 10.10.20.50.2-0.3-0.3-0.4-0.6-0.4-0.4-0.5-0.7-0.5
Vertical activity count, locomotor time 10.00.00.1-0.30.20.20.10.10.20.00.2-0.0-0.3
Time >=10cm from walls, locomotor time 21.21.72.71.3-1.4-1.3-1.2-1.0-1.4-1.4-1.5-1.6-0.8
Bouts of movement, locomotor time 20.10.10.30.4-0.3-0.4-0.5-0.0-0.4-0.6-0.3-0.3-0.2
Total resting periods, locomotor time 20.00.00.20.1-0.0-0.2-0.30.2-0.1-0.4-0.0-0.0-0.0
Rest time, locomotor task time 21.01.32.3-1.11.21.11.11.51.11.01.21.21.0
Distance moved, locomotor task time 20.00.00.2-0.20.00.10.1-0.1-0.00.1-0.2-0.5-0.0
Vertical activity count, locomotor time 20.00.10.2-0.40.20.20.2-0.00.10.0-0.1-0.4-0.4
Light reinforcement 11.22.93.81.7-1.6-1.7-1.8-1.8-1.7-1.8-1.5-1.3-2.0
Light reinforcement 20.50.80.90.8-0.9-0.8-0.9-1.0-0.9-0.9-0.9-0.8-0.9
Bone: marrow area1.53.34.7-2.22.12.01.81.81.81.71.81.51.3
Bone: maximum diameter0.00.00.00.0-0.0-0.1-0.1-0.1-0.1-0.1-0.00.0-0.1
Bone: maximum force0.00.00.10.2-0.1-0.2-0.3-0.3-0.2-0.2-0.2-0.1-0.2
Bone: maximum moment0.00.00.00.1-0.0-0.1-0.2-0.2-0.1-0.2-0.1-0.0-0.1
Mean time between licks in bursts1.02.53.7-1.71.61.61.61.91.51.51.51.31.3
Mean num. licks in bursts0.00.00.00.0-0.0-0.00.00.10.00.00.00.0-0.0
Cd content in liver0.90.91.3-1.11.21.00.81.11.00.81.11.20.3
Co content in liver2.12.52.8-1.71.61.61.61.61.61.61.61.51.4
Cu content in liver0.91.11.5-0.91.01.01.01.11.01.11.01.01.2
Fe content in liver2.22.73.1-1.71.71.71.81.61.71.71.61.41.7
K content in liver0.00.00.20.1-0.1-0.00.20.3-0.00.1-0.1-0.10.5
Mg content in liver0.10.10.40.1-0.2-0.10.10.0-0.2-0.0-0.4-0.60.4
Mn content in liver0.00.00.20.1-0.2-0.1-0.10.1-0.2-0.2-0.3-0.4-0.1
Na content in liver0.10.10.30.6-0.4-0.4-0.3-0.2-0.3-0.3-0.20.10.1
Rb content in liver1.41.61.71.2-1.3-1.3-1.2-1.1-1.3-1.3-1.3-1.3-1.3
Se content in liver2.83.34.12.0-2.0-1.9-1.8-1.7-1.9-1.8-1.9-1.7-1.3
Sr content in liver1.11.01.5-1.21.11.11.11.01.01.00.80.50.9
Zn content in liver1.51.71.91.3-1.3-1.3-1.3-1.1-1.3-1.3-1.4-1.4-1.2
Bone: minimum diameter0.40.71.1-1.01.00.90.80.70.90.90.80.70.5
Time in familiar zone, hab. session 10.60.61.00.7-0.7-0.7-0.8-0.8-0.7-0.8-0.7-0.7-1.0
Time in novel zone, hab. session 10.60.60.90.9-0.9-0.9-0.8-0.8-0.8-0.8-0.8-0.6-0.5
Total zone transitions, hab. session 12.33.23.9-2.01.91.91.91.81.81.81.71.41.7
Total locomotion distance, hab. session 10.00.00.0-0.20.20.20.10.10.10.10.10.1-0.1
Locomotion velocity, hab. session 10.50.71.0-1.01.00.90.80.80.80.80.80.70.5
Time in familiar zone, hab. session 20.70.71.10.8-0.8-0.9-0.9-0.9-0.8-1.0-0.8-0.7-1.1
Time in novel zone, hab. session 20.00.00.00.2-0.2-0.1-0.1-0.0-0.1-0.0-0.1-0.00.0
Total zone transitions, hab. session 20.60.71.0-1.01.00.90.91.00.90.80.80.70.5
Total locomotion distance, hab. session 20.10.10.2-0.40.40.30.20.30.30.20.30.2-0.3
Locomotion velocity, hab. session 20.20.20.5-0.70.60.60.40.50.50.40.50.4-0.1
Novel to familiar place preference ratio1.51.62.0-1.31.31.41.41.11.31.41.21.01.2
Novelty place preference0.80.91.2-1.01.01.01.00.81.01.10.90.70.8
Time in novel zone, NPP test0.20.20.3-0.50.40.50.50.40.50.60.40.30.4
Total zone transitions, NPP test0.30.40.6-0.80.70.70.70.60.70.60.70.60.5
Total locomotion distance, NPP test0.00.00.00.00.0-0.0-0.0-0.1-0.0-0.00.00.1-0.0
Locomotion velocity, NPP test0.30.40.5-0.70.70.70.60.50.60.60.60.60.5
Intraocular pressure1.11.62.5-1.61.51.41.31.31.41.31.21.00.7
Delta distance traveled before/after self-admin0.50.50.9-0.70.80.70.50.70.80.80.81.00.3
Delta ambulatory time before/after self-admin0.10.20.4-0.40.50.40.20.30.40.50.40.6-0.1
Parametrial fat weight0.61.41.90.8-0.9-1.0-1.2-1.3-1.2-1.2-1.2-1.3-1.4
Pavlov. Cond. lever latency2.63.33.9-2.01.91.91.91.81.81.81.71.51.8
Pavlov. Cond. magazine entry latency9.211.914.63.8-3.7-3.7-3.6-3.6-3.4-3.4-3.3-2.8-3.0
Pavlov. Cond. change in total contacts8.48.911.13.3-3.2-3.2-3.1-3.2-3.0-2.8-2.9-2.5-2.6
Pavlov. Cond. index score9.011.313.63.7-3.5-3.6-3.5-3.5-3.3-3.3-3.2-2.7-3.1
Pavlov. Cond. latency score6.98.710.73.3-3.1-3.1-3.1-3.1-2.9-2.9-2.8-2.4-2.7
Pavlov. Cond. lever contacts3.33.94.72.2-2.1-2.1-2.1-2.0-2.0-2.0-1.9-1.6-1.9
Pavlov. Cond. magazine entry number13.416.820.9-4.64.44.44.34.34.14.03.93.33.5
Pavlov. Cond. intertrial magazine entries1.51.82.4-1.41.41.41.41.51.31.41.31.11.3
Pavlov. Cond. lever-magazine prob. diff.10.513.015.64.0-3.8-3.8-3.8-3.8-3.6-3.6-3.4-2.9-3.3
Pavlov. Cond. response bias10.212.715.43.9-3.8-3.8-3.7-3.7-3.6-3.5-3.4-2.9-3.2
Pavlov. Cond. lever latency0.20.30.7-0.60.60.60.50.80.50.50.50.40.4
Pavlov. Cond. magazine entry latency0.00.10.2-0.10.10.20.30.10.20.20.20.20.4
Pavlov. Cond. change in total contacts0.30.50.80.8-0.7-0.8-0.7-0.9-0.7-0.8-0.6-0.6-0.7
Pavlov. Cond. index score0.10.10.40.5-0.4-0.4-0.3-0.6-0.3-0.3-0.3-0.3-0.2
Pavlov. Cond. latency score0.10.10.40.4-0.4-0.3-0.2-0.6-0.3-0.2-0.3-0.3-0.2
Pavlov. Cond. lever contacts0.40.61.10.8-0.8-0.8-0.7-1.0-0.7-0.7-0.7-0.6-0.7
Pavlov. Cond. magazine entry number0.10.20.3-0.50.50.40.30.50.40.40.40.30.3
Pavlov. Cond. intertrial magazine entries1.42.12.7-1.61.61.51.51.51.41.51.41.21.2
Pavlov. Cond. lever-magazine prob. diff.0.00.10.20.3-0.3-0.2-0.1-0.4-0.2-0.2-0.2-0.2-0.1
Pavlov. Cond. response bias0.60.91.21.1-1.0-1.0-0.9-1.1-0.9-0.9-0.9-0.7-0.7
Time in closed arm before self-admin1.72.22.91.5-1.5-1.5-1.7-1.5-1.5-1.5-1.4-1.1-1.5
Time in closed arm after self-admin0.30.40.6-0.50.60.60.60.40.60.60.70.80.4
Time in open arm before self-admin3.03.34.6-1.61.71.71.91.81.91.81.91.82.1
Time in open arm after self-admin0.50.60.9-0.70.70.70.80.90.70.70.70.50.9
Bone: periosteal estimation0.10.20.4-0.60.60.60.40.40.50.50.50.50.3
Bone: periosteal perimeter0.61.01.4-1.21.11.11.01.01.00.91.00.80.6
Bone: post-yield work0.50.81.2-1.11.11.00.91.00.90.80.90.70.5
Progressive ratio test 1 active lever presses0.60.71.10.5-0.6-0.6-0.8-0.9-0.8-0.8-0.9-1.1-1.1
Progressive ratio test 1 breakpoint0.60.71.40.4-0.6-0.6-0.9-0.9-0.8-0.8-0.9-1.0-1.2
Progressive ratio test 1 inactive lever presses0.10.10.60.0-0.1-0.2-0.4-0.3-0.3-0.5-0.3-0.4-0.8
Progressive ratio test 2 active lever presses0.40.50.70.6-0.7-0.7-0.7-0.8-0.7-0.7-0.8-0.8-0.7
Progressive ratio test 2 breakpoint0.50.60.80.7-0.7-0.7-0.7-0.8-0.8-0.8-0.8-0.9-0.7
Progressive ratio test 2 inactive lever presses0.10.20.4-0.40.40.40.50.50.50.40.40.30.6
Incentive Sensitization - Responses0.40.50.70.8-0.8-0.8-0.6-0.7-0.7-0.7-0.8-0.8-0.4
Incentive Sensitization - Breakpoint0.30.40.50.7-0.7-0.7-0.5-0.6-0.6-0.6-0.6-0.7-0.2
Sum of active levers in priming session hrs 5-60.20.20.80.1-0.3-0.2-0.3-0.4-0.4-0.3-0.6-0.9-0.5
Progressive ratio0.00.00.0-0.20.20.20.10.00.10.10.10.0-0.2
Food seeking constrained by brief footshock0.40.50.80.8-0.7-0.8-0.9-0.7-0.8-0.7-0.7-0.5-0.6
Seeking ratio, punishment vs. effort0.20.20.30.6-0.6-0.5-0.6-0.4-0.5-0.5-0.5-0.5-0.1
Retroperitoneal fat weight0.20.81.40.6-0.6-0.7-1.0-0.9-0.9-1.0-0.9-0.9-1.2
Reaction time number correct0.51.01.2-1.11.11.11.11.11.01.01.01.00.7
Reaction time mean minus median0.00.00.1-0.20.20.20.20.10.20.20.20.30.3
Reaction time mean minus median AUC0.20.40.50.7-0.7-0.7-0.7-0.6-0.7-0.7-0.6-0.5-0.6
Reaction time num false alarms0.60.91.00.9-0.9-0.9-0.9-1.0-0.9-1.0-1.0-1.0-0.9
Reaction time num false alarms AUC0.40.60.80.7-0.7-0.7-0.8-0.9-0.8-0.8-0.9-0.9-0.9
Reaction time trials correct on left0.51.01.2-1.11.11.11.11.11.01.01.01.00.7
Reaction time trials on left0.51.01.1-1.01.01.01.01.01.01.01.00.90.7
Reaction time mean0.00.10.40.4-0.2-0.2-0.00.00.00.00.10.40.6
Reaction time mean AUC0.00.10.40.3-0.1-0.10.00.10.10.10.20.40.6
Median of all reaction times0.10.20.60.8-0.6-0.6-0.4-0.3-0.3-0.3-0.20.20.5
Reaction time omissions0.40.50.70.6-0.6-0.6-0.7-0.8-0.8-0.7-0.8-0.8-0.8
Reaction time false alarm rate1.21.61.91.2-1.3-1.2-1.3-1.4-1.3-1.3-1.3-1.3-1.2
Reaction time premature initiation rate0.40.51.20.3-0.5-0.5-0.7-0.7-0.8-0.6-0.9-1.1-0.9
Reaction time premature initiations0.00.10.3-0.50.40.30.20.20.10.2-0.0-0.3-0.2
Std. dev. reaction times0.00.00.10.2-0.2-0.2-0.1-0.2-0.2-0.1-0.1-0.00.1
Reaction time trials completed0.51.01.1-1.01.01.01.01.01.01.01.00.90.7
Reaction time trials AUC0.40.81.0-0.91.00.90.91.00.90.90.90.90.7
Run reversals in cocaine runway, females1.21.21.7-1.31.21.21.11.11.11.01.10.80.8
Run reversals in cocaine runway, males0.20.20.60.8-0.6-0.7-0.5-0.5-0.4-0.5-0.20.0-0.4
Latency to leave start box in cocaine runway3.03.45.2-1.51.71.71.72.01.91.62.12.31.9
Latency to leave start box in cocaine runway, F3.54.16.1-1.71.91.81.92.02.01.92.22.52.1
Latency to leave start box in cocaine runway, M0.50.41.1-0.40.50.50.60.80.60.50.70.71.1
Std. dev. time between licks in bursts0.30.50.9-0.60.60.70.70.60.60.70.60.51.0
Total sessions with >9 infusions0.10.10.5-0.0-0.0-0.1-0.3-0.3-0.2-0.2-0.2-0.2-0.7
Short access day 1 total inactive lever presses1.11.42.50.7-0.9-1.0-1.1-1.1-1.2-1.2-1.3-1.6-1.6
Short access day 10 total inactive lever presses0.30.71.9-0.60.80.70.60.90.90.61.11.40.5
Short access day 1 total infusions0.00.00.10.1-0.1-0.1-0.2-0.1-0.2-0.1-0.2-0.2-0.3
Short access day 10 total infusions0.20.20.50.5-0.5-0.5-0.6-0.5-0.4-0.4-0.5-0.4-0.7
Short access total infusions0.00.00.0-0.10.10.1-0.00.00.00.00.00.0-0.1
Short access day 1 locomotion0.60.70.80.8-0.8-0.9-0.9-0.9-0.9-0.9-0.9-0.8-0.9
Short access day 10 total locomotion2.03.64.72.0-1.9-2.0-2.0-1.9-1.9-1.9-1.8-1.6-2.2
Short access total locomotion0.30.41.00.5-0.5-0.6-0.7-0.6-0.6-0.7-0.5-0.4-1.0
One hour access (0.3 mA shock)0.00.10.2-0.20.1-0.0-0.3-0.2-0.1-0.2-0.1-0.2-0.5
Compulsive drug intake0.20.20.80.1-0.3-0.2-0.3-0.5-0.5-0.4-0.7-0.9-0.1
One hour access (shock baseline)0.10.10.3-0.30.40.20.00.20.30.10.40.6-0.4
Social response proportion0.10.10.4-0.20.00.00.10.0-0.2-0.2-0.3-0.7-0.1
Social responses0.10.10.20.2-0.2-0.3-0.3-0.3-0.4-0.4-0.4-0.5-0.5
Social time0.00.00.20.10.0-0.0-0.1-0.00.10.00.20.40.1
Soleus weight0.51.41.81.4-1.3-1.3-1.2-1.3-1.2-1.1-1.1-0.9-0.9
Bone: stiffness0.00.10.10.2-0.1-0.2-0.3-0.3-0.2-0.3-0.2-0.1-0.3
Tibialis anterior weight1.44.65.6-2.22.12.22.42.12.22.32.01.72.2
Time to tail flick, vehicle, before self-admin0.40.51.00.3-0.5-0.5-0.6-0.7-0.6-0.6-0.8-1.0-0.9
Time to tail flick, vehicle, after self-admin0.00.10.30.4-0.3-0.2-0.2-0.5-0.1-0.1-0.10.10.0
Time to tail flick, test, before self-admin0.30.30.7-0.50.60.50.40.30.60.60.70.80.1
Time to tail flick, test, after self-admin0.10.10.10.4-0.3-0.3-0.3-0.3-0.3-0.2-0.3-0.2-0.0
Delta time to tail flick, vehicle, before/after SA0.30.30.70.8-0.7-0.7-0.6-0.6-0.5-0.5-0.4-0.1-0.4
Delta time to tail flick, test, before/after SA1.71.83.21.2-1.4-1.3-1.1-1.1-1.4-1.3-1.5-1.8-0.8
Tibia length0.72.02.4-1.51.41.51.51.21.41.51.31.11.5
Ambulatory time before self-admin0.40.60.9-0.90.90.80.81.00.70.50.80.60.4
Ambulatory time after self-admin1.82.22.9-1.71.71.61.31.51.51.41.51.50.7
Bone: tissue strength0.50.51.0-0.60.60.70.80.50.70.80.60.61.0
Total heroin consumption0.30.30.60.7-0.7-0.6-0.5-0.4-0.6-0.6-0.7-0.8-0.1
Bone: trabecular number4.98.110.13.2-3.0-3.1-3.0-2.9-2.9-2.8-2.7-2.3-2.4
Bone: trabecular spacing0.81.11.5-1.21.21.11.11.11.11.01.00.80.6
Bone: trabecular thickness0.00.00.10.1-0.1-0.1-0.00.0-0.10.0-0.1-0.00.3
Bone: trabecular tissue density0.00.00.0-0.10.10.10.10.10.10.10.10.10.1
Water consumed over 24 hours0.00.00.0-0.10.10.10.1-0.20.00.10.10.10.2
Number of responses in last shaping day0.20.20.6-0.20.30.30.40.20.40.50.40.60.8