Hub : Genes

Ctxn1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Ctxn1 0.12 0.07 1.8e-06 0.03 0.03 0.03 0.03 1.0e-04 6.8e-04 1.9e-04 9.9e-05
2 IC gene expression Ctxn1 0.39 0.14 1.1e-16 0.19 0.31 0.31 0.31 3.0e-08 9.8e-14 2.2e-13 1.6e-13
3 BLA gene expression Ctxn1 0.4 0.15 9.4e-16 0.26 0.3 0.28 0.29 5.7e-14 2.8e-16 4.0e-15 1.4e-15
4 Brain gene expression Ctxn1 0.47 0.13 0.0e+00 0.5 0.54 0.54 0.54 1.2e-53 1.8e-59 3.6e-59 1.0e-58
5 PL gene expression Ctxn1 0.19 0.09 0.0e+00 0.24 0.25 0.25 0.25 2.3e-26 3.2e-27 6.3e-27 5.2e-27
6 NAcc gene expression Ctxn1 0.2 0.1 0.0e+00 0.2 0.21 0.21 0.21 3.0e-29 1.7e-31 1.0e-31 2.4e-31
7 Brain mRNA stability Ctxn1 0.03 0.02 7.1e-04 0.03 0.03 0.02 0.02 9.4e-04 1.0e-03 2.7e-03 5.1e-03
8 OFC gene expression Ctxn1 0.13 0.08 2.4e-03 0.1 0.12 0.11 0.11 1.9e-03 7.6e-04 1.3e-03 1.3e-03
9 IL gene expression Ctxn1 0.25 0.14 8.8e-05 0.18 0.16 0.25 0.18 3.9e-05 9.1e-05 1.1e-06 3.5e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.71.36.9-2.6-0.6-0.00.20.50.61.11.5-0.4
Area under the delay curve1.21.42.91.71.31.21.21.11.21.10.80.3
BMI with tail0.41.23.7-1.9-0.10.30.50.70.91.01.6-1.5
BMI without tail0.61.810.8-3.3-1.4-0.7-0.6-0.2-0.10.41.0-1.0
Body weight2.29.555.5-7.5-3.8-2.5-2.0-1.3-0.80.41.5-1.3
Weight adjusted by age0.20.40.8-0.9-0.9-0.7-0.8-0.6-0.4-0.2-0.40.1
Bone surface0.71.48.0-2.8-0.8-0.20.00.30.40.71.4-0.7
Bone volume0.91.73.8-1.90.10.70.91.11.21.42.0-1.4
Breakpoint value in progressive ratio session0.81.01.8-0.30.70.90.91.01.01.01.3-1.3
Number of licking bursts5.69.111.1-1.6-3.1-3.2-3.3-3.3-3.3-3.2-3.22.4
Context. condit. distance diff. score1.92.35.0-2.10.20.91.01.31.52.12.2-1.1
Locomotion velocity, session 10.40.40.70.80.70.70.50.60.50.30.3-0.9
Locomotion distance, session 10.30.41.71.30.80.60.50.40.50.40.0-0.3
Locomotion velocity, session 20.30.40.60.6-0.3-0.5-0.5-0.6-0.7-0.7-0.80.5
Locomotion distance, session 20.10.21.21.10.1-0.1-0.2-0.2-0.2-0.2-0.60.2
Locomotion velocity, session 30.70.81.7-0.80.50.70.80.91.01.31.2-0.1
Locomotion distance, session 30.10.10.4-0.70.10.10.20.20.40.50.30.5
Stereotopy head waving bouts, day 30.50.61.8-1.3-1.1-0.8-0.8-0.6-0.5-0.0-0.1-0.1
Stereotopy head waving duration, day 30.10.10.60.80.10.00.00.0-0.1-0.0-0.1-0.7
Locomotion velocity, session 70.40.42.51.60.60.40.40.30.40.20.0-0.6
Locomotion distance, session 70.20.20.60.80.40.40.40.40.50.40.4-0.3
Stereotopy head waving bouts, day 70.10.10.20.40.40.40.30.30.30.40.20.5
Stereotopy head waving duration, day 70.10.20.70.80.50.40.30.20.20.2-0.10.5
Locomotion velocity, session 80.10.10.5-0.1-0.3-0.3-0.2-0.2-0.20.1-0.10.7
Locomotion distance, session 80.20.41.1-1.0-0.20.10.20.40.50.90.9-0.2
Degree of sensitization distance0.40.42.81.70.30.10.0-0.1-0.3-0.7-0.5-0.1
Degree of sensitization stereotypy0.40.40.60.50.80.70.70.60.60.60.40.8
Conditioned locomotion0.70.81.1-0.30.70.80.90.91.01.01.1-0.8
Cocaine response after cond. corrected0.10.10.40.60.1-0.1-0.0-0.1-0.3-0.7-0.3-0.5
Cocaine response after cond. not corrected0.70.81.40.70.91.01.01.00.80.50.9-1.2
Cocaine response before conditioning3.54.26.6-0.11.72.12.12.32.42.52.6-1.5
Saline control response2.33.18.7-2.9-2.2-1.7-1.9-1.6-1.4-1.1-0.81.1
Bone: connectivity density1.11.811.8-3.4-1.4-0.7-0.5-0.10.10.61.10.0
Bone: cortical apparent density0.10.20.70.90.50.30.30.20.20.2-0.10.5
Bone: cortical area0.50.82.2-1.5-0.10.30.40.60.70.81.2-1.4
Bone: cortical porosity0.10.10.2-0.2-0.4-0.3-0.5-0.4-0.5-0.3-0.40.1
Bone: cortical porosity0.10.10.20.30.30.40.20.30.20.30.2-0.3
Bone: cortical thickness0.20.42.1-1.5-0.4-0.20.00.10.20.40.8-0.7
Bone: cortical thickness0.30.31.9-1.4-0.6-0.4-0.3-0.2-0.3-0.00.30.3
Bone: cortical tissue density0.10.20.80.90.40.20.30.10.10.1-0.20.6
Condit. Reinf. active minus inactive responses0.91.11.91.01.21.21.11.00.80.50.7-1.4
Condit. Reinf. active-inactive response ratio1.31.33.90.81.21.21.11.11.00.70.9-2.0
Condit. Reinf. active responses1.01.21.60.71.21.21.11.11.11.01.0-1.2
Condit. Reinf. inactive responses0.40.40.90.50.70.70.60.60.81.00.50.2
Incentive salience index mean1.51.82.50.71.51.51.51.41.31.11.3-1.6
Condit. Reinf. lever presses1.52.12.50.61.51.61.61.61.51.41.5-1.6
Condit. Reinf. active minus inactive responses0.30.42.1-1.5-0.8-0.6-0.5-0.4-0.4-0.30.00.5
Condit. Reinf. active-inactive response ratio0.40.40.9-1.0-0.7-0.7-0.6-0.6-0.6-0.6-0.50.5
Condit. Reinf. active responses0.30.51.9-1.4-0.10.20.30.50.40.61.0-0.6
Condit. Reinf. inactive responses0.70.81.9-0.60.50.80.81.00.81.01.4-1.1
Condit. Reinf. lever presses1.31.73.0-0.61.01.31.31.41.51.71.7-0.8
Condit. Reinf. lever reinforcers received0.30.41.1-1.10.00.30.40.50.40.60.9-0.5
Conditioned reinforcement - actives1.11.96.3-2.5-1.9-1.6-1.4-1.2-1.1-0.7-0.30.3
Conditioned reinforcement - inactives1.21.72.0-1.0-1.4-1.4-1.4-1.4-1.4-1.4-1.11.2
Conditioned locomotion0.60.84.8-2.2-0.7-0.1-0.00.20.30.61.1-0.5
Patch foraging indifference point 0 sec0.00.00.1-0.4-0.1-0.10.00.0-0.00.20.10.3
Patch foraging indifference point AUC1.01.52.3-1.5-1.5-1.4-1.2-1.2-1.2-1.1-0.70.9
Delay disc. indifference point, 0s delay0.00.00.20.50.20.10.20.20.10.20.1-0.0
Delay disc. indifference point, 16s delay0.40.41.11.00.50.40.50.40.70.50.41.0
Delay disc. indifference point, 2s delay4.75.27.22.42.72.62.52.52.21.91.9-1.4
Delay disc. indifference point, 24s delay0.20.31.51.20.2-0.10.0-0.1-0.1-0.1-0.40.8
Delay disc. indifference point, 4s delay2.62.83.71.61.91.91.91.81.71.61.5-0.7
Delay disc. indifference point, 8s delay0.60.71.10.80.90.80.90.81.01.10.70.0
Indifference point function ln k0.00.10.1-0.3-0.3-0.0-0.4-0.20.00.2-0.2-0.2
Indifference point function log k0.00.10.1-0.3-0.3-0.0-0.4-0.20.00.2-0.2-0.2
Patch foraging total patch changes 0 sec0.00.00.2-0.5-0.2-0.1-0.0-0.0-0.00.10.10.4
Patch foraging total patch changes 12 sec0.10.10.4-0.6-0.3-0.2-0.1-0.1-0.10.20.10.3
Patch foraging total patch changes 18 sec0.40.71.3-0.6-0.8-0.8-0.8-0.8-0.9-1.1-0.60.7
Patch foraging total patch changes 24 sec0.10.20.8-0.50.10.10.30.30.20.40.50.9
Patch foraging total patch changes 6 sec0.10.10.7-0.9-0.3-0.2-0.1-0.1-0.10.40.20.0
Patch foraging time to switch 0 sec1.02.06.92.61.71.31.31.11.10.80.2-1.3
Patch foraging water rate 0 sec1.12.39.3-3.1-2.0-1.4-1.4-1.1-1.1-0.8-0.20.1
Patch foraging water rate 12 sec0.10.21.3-1.2-0.30.0-0.10.10.20.40.5-0.2
Patch foraging water rate 18 sec0.30.51.5-0.30.50.80.50.70.71.20.8-0.6
Patch foraging water rate 24 sec0.81.14.8-2.2-1.2-0.6-0.9-0.5-0.40.10.1-1.3
Patch foraging water rate 6 sec0.50.81.7-1.20.20.70.60.80.91.01.3-0.8
Seeking ratio, delayed vs. immediate footshock1.11.43.21.2-0.4-0.9-0.8-1.1-1.3-1.8-1.80.6
Distance traveled before self-admin0.91.22.31.51.31.31.21.11.00.90.8-0.4
Distance traveled after self-admin0.40.40.60.80.50.50.70.60.60.70.80.7
Extensor digitorum longus weight1.03.923.9-4.9-1.4-0.4-0.10.40.71.22.4-1.0
Bone: elastic displacement0.20.20.6-0.8-0.6-0.5-0.5-0.4-0.40.0-0.20.5
Bone: elastic work0.91.26.9-2.6-1.4-0.9-0.8-0.5-0.40.30.40.2
Bone: endosteal estimation0.61.43.6-1.9-1.5-1.2-1.3-1.1-1.0-0.6-0.50.5
Bone: endosteal perimeter0.30.73.0-1.7-0.30.30.20.50.50.91.2-0.7
Epididymis fat weight0.61.93.80.11.11.31.41.51.41.91.7-1.1
Delta time in closed arm before/after self-admin0.10.10.20.3-0.4-0.2-0.3-0.2-0.4-0.5-0.10.0
Delta time in open arm before/after self-admin2.32.34.10.62.01.81.71.61.51.30.9-1.7
Diff in mean of infusions in LGA sessions0.20.20.5-0.50.10.30.30.40.50.70.6-0.5
Delay discount exponential model param1.71.93.7-1.9-1.6-1.4-1.5-1.4-1.5-1.3-1.0-0.2
Extinction: sum of active levers before priming1.31.41.90.71.21.21.41.31.31.21.3-1.0
Active lever presses in extinction session 60.20.20.5-0.50.10.20.40.40.30.40.7-0.7
Bone: final force1.22.05.2-2.3-1.9-1.6-1.5-1.3-1.3-0.8-0.60.1
Bone: final moment1.21.94.3-2.1-1.8-1.6-1.5-1.3-1.3-0.8-0.70.2
Food consumed during 24 hour testing period0.91.32.2-1.1-1.2-1.1-1.2-1.2-1.2-1.5-1.10.4
Glucose0.60.93.51.91.20.90.90.70.60.60.10.5
Heart weight0.40.61.9-1.2-0.9-0.6-0.7-0.5-0.6-0.3-0.11.4
Delay discount hyperbolic model param1.82.03.5-1.9-1.6-1.5-1.5-1.5-1.5-1.3-1.1-0.0
Intermittent access intake day 1-15 change1.42.83.8-1.4-1.9-2.0-1.8-1.8-1.8-1.6-1.31.4
Intermittent access intake escalation1.42.94.1-1.4-1.9-2.0-1.8-1.8-1.8-1.7-1.41.2
Intermittent access intake escalation 21.11.31.9-0.3-1.0-1.2-1.1-1.2-1.3-1.4-1.11.3
Intermitt. access day 1 inactive lever presses0.41.41.8-0.6-1.2-1.4-1.3-1.3-1.3-1.2-1.21.0
Intermitt. access day 15 inactive lever presses0.10.20.70.80.40.30.20.20.30.2-0.1-0.6
Intermitt. access escalation Index0.50.71.00.20.80.90.80.91.00.90.9-0.7
Intermittent access day 1 total infusions0.30.40.60.50.70.80.70.70.70.70.6-0.5
Intermittent access day 15 total infusions0.10.10.2-0.5-0.4-0.4-0.4-0.4-0.3-0.2-0.20.3
Intermittent access terminal intake (last 3 days)0.00.10.1-0.1-0.2-0.3-0.2-0.3-0.2-0.3-0.20.3
Intermittent access total infusions0.20.20.30.30.50.50.60.50.60.50.5-0.4
Intermittent access day 1 locomotion2.02.53.60.71.71.81.71.71.91.91.6-0.9
Intermittent access day 15 total locomotion0.20.51.0-0.90.20.50.40.60.80.91.0-0.0
Intermittent access total locomotion1.21.41.90.21.11.31.31.41.41.31.4-0.5
Intermittent access standard deviation0.51.11.4-0.1-0.9-1.1-1.0-1.1-1.1-1.2-1.11.1
Left kidney weight2.19.848.5-7.0-4.1-3.0-2.6-2.0-1.6-0.50.5-0.1
Right kidney weight1.88.336.5-6.0-3.9-2.8-2.6-2.1-1.7-0.60.0-0.7
Cocaine induced anxiety1.11.62.20.41.31.31.51.41.41.41.5-1.0
Post-drug Anxiety4.75.17.22.62.72.42.42.32.31.91.5-1.9
Baseline Anxiety0.91.06.62.61.00.50.30.10.2-0.2-0.9-0.1
Tail length2.38.839.8-6.3-4.0-2.9-2.7-2.1-1.7-0.40.00.1
Length with tail4.318.983.3-9.1-5.8-4.4-3.9-3.1-2.6-0.90.00.3
Length without tail2.78.736.0-6.0-4.0-3.1-2.7-2.3-1.8-0.6-0.20.2
Times rat made contact with spout1.01.23.0-1.7-1.3-1.0-1.2-1.0-1.0-1.0-0.8-0.0
Lifetime Intake0.30.40.60.70.80.70.70.60.60.50.5-0.6
Liver weight, left3.55.79.2-3.0-3.0-2.7-2.7-2.5-2.3-2.0-1.70.6
Liver weight, right0.50.94.5-2.1-1.1-0.6-0.6-0.4-0.2-0.10.4-1.0
Locomotor activity0.71.05.3-2.3-1.2-0.8-0.8-0.5-0.40.40.30.9
Locomotor testing distance0.40.82.4-1.5-1.2-0.8-1.0-0.8-0.7-0.2-0.30.6
Locomotor testing rearing0.00.10.60.00.10.30.00.20.20.20.1-0.8
Locomotion in novel chamber1.31.63.1-1.8-1.5-1.3-1.3-1.2-1.4-1.1-0.70.9
Locomotion in novel chamber post-restriction0.40.63.4-1.9-1.0-0.6-0.7-0.5-0.40.10.1-0.0
Fecal boli incidents, locomotor time 10.40.52.7-1.6-1.0-0.5-0.6-0.3-0.3-0.10.4-0.1
Change in fecal boli incidents, locomotor task0.20.20.80.4-0.2-0.4-0.4-0.5-0.4-0.5-0.9-0.0
Time >=10cm from walls, locomotor time 12.83.03.81.71.91.91.81.81.91.51.5-1.3
Bouts of movement, locomotor time 10.60.71.7-1.3-1.2-0.9-0.9-0.7-0.6-0.4-0.10.9
Total resting periods, locomotor time 10.50.61.4-1.2-1.1-0.8-0.7-0.6-0.5-0.4-0.00.8
Rest time, locomotor task time 10.20.31.6-1.3-0.6-0.2-0.3-0.00.20.60.50.0
Distance moved, locomotor task time 10.10.10.60.80.50.30.30.20.0-0.2-0.20.1
Vertical activity count, locomotor time 10.10.20.40.2-0.3-0.5-0.3-0.4-0.5-0.7-0.30.6
Time >=10cm from walls, locomotor time 21.42.13.60.61.11.41.41.51.71.91.6-1.5
Bouts of movement, locomotor time 20.30.51.3-1.2-0.00.30.30.50.80.91.0-0.2
Total resting periods, locomotor time 20.20.41.4-1.2-0.20.20.20.40.60.70.9-0.1
Rest time, locomotor task time 20.70.91.4-0.20.81.10.80.91.11.20.9-1.0
Distance moved, locomotor task time 22.02.43.50.2-1.4-1.7-1.6-1.7-1.8-1.5-1.71.9
Vertical activity count, locomotor time 23.04.15.9-0.8-2.3-2.4-2.1-2.1-2.1-1.7-1.62.4
Light reinforcement 10.71.72.71.51.61.41.51.31.31.30.9-0.6
Light reinforcement 20.20.30.60.6-0.2-0.5-0.4-0.5-0.6-0.6-0.80.7
Bone: marrow area0.61.43.5-1.9-1.5-1.3-1.3-1.1-1.1-0.7-0.50.6
Bone: maximum diameter0.30.52.7-1.7-0.5-0.1-0.00.20.30.40.8-0.9
Bone: maximum force0.61.15.2-2.3-1.4-1.0-1.0-0.8-0.7-0.20.0-0.2
Bone: maximum moment0.61.14.4-2.1-1.4-1.1-1.0-0.8-0.8-0.3-0.1-0.1
Mean time between licks in bursts0.30.71.71.31.10.90.80.70.90.90.3-0.2
Mean num. licks in bursts1.82.83.60.21.51.81.71.91.81.71.9-1.8
Cd content in liver0.00.00.1-0.1-0.1-0.1-0.1-0.1-0.10.2-0.1-0.3
Co content in liver3.03.54.9-0.7-1.9-2.0-2.1-2.1-2.2-2.2-2.11.1
Cu content in liver0.00.10.3-0.20.00.10.10.10.20.00.2-0.6
Fe content in liver3.13.87.1-1.21.31.81.92.12.32.42.7-1.1
K content in liver0.80.82.00.40.80.80.90.90.90.80.8-1.4
Mg content in liver0.20.20.3-0.5-0.6-0.6-0.5-0.5-0.5-0.4-0.4-0.3
Mn content in liver0.91.02.00.1-0.8-1.0-1.0-1.1-1.2-1.2-1.40.5
Na content in liver0.10.10.6-0.8-0.6-0.4-0.3-0.2-0.10.00.10.3
Rb content in liver3.03.55.72.32.42.12.11.91.81.41.3-0.9
Se content in liver5.46.49.3-0.02.12.42.62.72.82.83.1-3.0
Sr content in liver2.32.02.6-0.5-1.5-1.6-1.5-1.6-1.6-1.5-1.51.1
Zn content in liver1.51.63.8-2.0-1.7-1.5-1.3-1.2-1.1-0.9-0.50.1
Bone: minimum diameter0.00.10.20.0-0.2-0.2-0.3-0.3-0.4-0.5-0.4-0.2
Time in familiar zone, hab. session 10.20.20.40.5-0.0-0.1-0.3-0.3-0.4-0.6-0.6-0.4
Time in novel zone, hab. session 10.00.00.2-0.4-0.2-0.2-0.1-0.00.10.10.20.3
Total zone transitions, hab. session 10.50.71.71.31.20.91.00.90.60.20.5-0.2
Total locomotion distance, hab. session 11.62.33.41.21.81.61.81.71.51.31.5-1.0
Locomotion velocity, hab. session 12.02.84.41.52.11.82.01.81.61.41.5-1.0
Time in familiar zone, hab. session 20.20.20.70.80.40.30.30.30.20.20.2-0.8
Time in novel zone, hab. session 20.00.00.1-0.10.20.20.10.10.20.20.10.3
Total zone transitions, hab. session 21.01.31.6-0.5-1.1-1.2-1.2-1.2-1.3-1.3-1.11.2
Total locomotion distance, hab. session 20.00.00.20.10.1-0.00.0-0.0-0.1-0.3-0.10.4
Locomotion velocity, hab. session 20.10.10.60.1-0.1-0.2-0.1-0.2-0.4-0.5-0.30.8
Novel to familiar place preference ratio0.70.82.1-0.3-0.7-0.8-0.9-0.9-0.8-0.8-1.01.5
Novelty place preference0.60.62.1-0.0-0.4-0.6-0.7-0.7-0.7-0.8-1.01.5
Time in novel zone, NPP test0.60.62.2-0.0-0.5-0.6-0.7-0.7-0.7-0.6-0.91.5
Total zone transitions, NPP test0.00.00.10.2-0.2-0.1-0.1-0.1-0.1-0.10.1-0.2
Total locomotion distance, NPP test1.62.22.90.41.41.51.61.61.71.61.7-1.5
Locomotion velocity, NPP test1.11.52.30.11.11.21.31.31.41.31.5-1.4
Intraocular pressure0.50.73.2-1.8-0.30.20.30.50.50.71.3-0.2
Delta distance traveled before/after self-admin1.11.22.1-0.7-1.2-1.3-1.1-1.1-1.0-1.0-0.81.5
Delta ambulatory time before/after self-admin0.40.50.90.1-0.6-0.7-0.6-0.7-0.7-0.8-0.70.9
Parametrial fat weight0.10.30.70.40.50.40.50.50.60.50.5-0.9
Pavlov. Cond. lever latency2.02.53.8-1.7-2.0-1.7-1.7-1.6-1.5-1.2-1.11.5
Pavlov. Cond. magazine entry latency0.20.31.6-1.0-0.20.0-0.00.10.30.30.4-1.3
Pavlov. Cond. change in total contacts1.61.74.40.81.31.21.31.21.21.10.9-2.1
Pavlov. Cond. index score1.01.24.20.21.01.01.01.01.00.91.0-2.1
Pavlov. Cond. latency score1.21.54.00.51.21.21.21.21.21.01.0-2.0
Pavlov. Cond. lever contacts1.92.23.31.51.81.61.61.51.41.11.0-1.7
Pavlov. Cond. magazine entry number0.70.93.60.8-0.4-0.6-0.6-0.7-0.9-0.9-1.01.9
Pavlov. Cond. intertrial magazine entries0.20.31.71.30.30.20.1-0.00.00.1-0.40.7
Pavlov. Cond. lever-magazine prob. diff.1.01.34.30.21.01.01.01.01.01.01.0-2.1
Pavlov. Cond. response bias0.81.03.6-0.50.60.80.80.90.90.91.0-1.9
Pavlov. Cond. lever latency1.21.62.2-0.2-1.3-1.4-1.4-1.4-1.4-1.5-1.40.7
Pavlov. Cond. magazine entry latency2.02.43.81.32.01.81.81.71.61.41.3-0.8
Pavlov. Cond. change in total contacts0.30.51.30.10.70.70.70.80.91.10.8-0.0
Pavlov. Cond. index score1.41.92.50.91.61.61.61.51.41.41.3-0.6
Pavlov. Cond. latency score1.52.02.70.91.61.61.61.61.51.51.4-0.6
Pavlov. Cond. lever contacts1.82.53.30.31.61.71.71.81.71.81.7-1.0
Pavlov. Cond. magazine entry number1.11.32.3-1.1-1.5-1.4-1.4-1.3-1.1-1.0-0.90.2
Pavlov. Cond. intertrial magazine entries0.60.81.7-1.3-1.2-1.0-1.0-0.9-0.8-0.7-0.6-0.3
Pavlov. Cond. lever-magazine prob. diff.1.31.72.40.81.51.51.51.41.41.41.2-0.5
Pavlov. Cond. response bias2.73.64.60.72.12.12.12.22.02.02.0-1.2
Time in closed arm before self-admin2.32.94.4-1.5-2.0-2.1-1.9-1.8-1.7-1.3-1.31.6
Time in closed arm after self-admin2.83.04.6-1.2-2.1-2.0-1.9-1.8-1.8-1.5-1.11.9
Time in open arm before self-admin0.10.10.30.50.20.20.30.30.40.30.4-0.1
Time in open arm after self-admin2.42.64.40.81.81.81.61.61.71.51.1-2.1
Bone: periosteal estimation0.40.94.8-2.2-1.2-0.8-0.7-0.5-0.4-0.10.3-0.3
Bone: periosteal perimeter1.01.83.5-1.20.61.11.11.31.41.61.9-1.6
Bone: post-yield work0.50.71.6-0.70.50.70.80.90.90.91.3-0.6
Progressive ratio test 1 active lever presses0.50.61.6-1.2-1.0-0.9-0.8-0.7-0.6-0.4-0.30.2
Progressive ratio test 1 breakpoint0.50.61.5-1.2-1.0-0.9-0.8-0.7-0.6-0.4-0.30.2
Progressive ratio test 1 inactive lever presses1.31.92.7-1.4-1.6-1.6-1.5-1.5-1.4-1.3-1.10.9
Progressive ratio test 2 active lever presses1.41.62.4-1.5-1.5-1.5-1.3-1.3-1.2-1.1-0.80.9
Progressive ratio test 2 breakpoint1.31.52.2-1.4-1.5-1.5-1.3-1.3-1.2-1.1-0.80.8
Progressive ratio test 2 inactive lever presses1.42.36.3-2.5-2.0-1.6-1.7-1.4-1.2-0.9-0.60.8
Incentive Sensitization - Responses0.20.30.4-0.0-0.4-0.6-0.5-0.6-0.5-0.6-0.60.6
Incentive Sensitization - Breakpoint0.20.20.40.1-0.3-0.5-0.4-0.5-0.4-0.6-0.50.6
Sum of active levers in priming session hrs 5-60.90.81.7-0.30.80.71.00.90.91.01.0-1.3
Progressive ratio0.40.71.60.8-0.3-0.6-0.7-0.8-0.9-1.1-1.30.4
Food seeking constrained by brief footshock0.20.21.01.00.30.1-0.0-0.1-0.2-0.6-0.6-0.2
Seeking ratio, punishment vs. effort0.10.10.7-0.8-0.3-0.10.00.10.20.20.5-0.1
Retroperitoneal fat weight1.25.26.71.32.32.32.52.42.32.42.2-2.6
Reaction time number correct0.61.22.1-1.4-1.3-1.2-1.1-1.0-0.9-1.1-0.60.9
Reaction time mean minus median1.53.85.6-0.01.72.22.02.22.32.22.4-1.5
Reaction time mean minus median AUC0.81.92.70.41.31.71.41.51.61.61.5-0.9
Reaction time num false alarms0.60.81.20.20.81.00.81.01.11.11.0-0.9
Reaction time num false alarms AUC0.81.31.9-0.00.91.21.11.21.31.41.3-1.1
Reaction time trials correct on left0.61.22.1-1.4-1.3-1.2-1.1-1.0-0.9-1.1-0.60.9
Reaction time trials on left0.61.12.0-1.4-1.3-1.1-1.1-1.0-0.8-1.0-0.60.8
Reaction time mean1.62.55.72.42.01.81.61.51.41.10.7-1.0
Reaction time mean AUC1.72.75.52.42.11.91.71.61.61.30.8-1.1
Median of all reaction times1.41.98.62.91.81.41.21.00.90.6-0.0-0.6
Reaction time omissions1.42.02.71.11.51.61.41.41.61.61.1-1.3
Reaction time false alarm rate1.82.43.60.61.51.71.61.71.71.91.6-1.5
Reaction time premature initiation rate0.20.30.70.20.50.50.50.50.40.30.5-0.8
Reaction time premature initiations0.00.10.3-0.4-0.00.00.10.1-0.0-0.20.2-0.5
Std. dev. reaction times1.73.24.41.11.92.11.92.02.01.81.7-1.5
Reaction time trials completed0.61.12.0-1.4-1.3-1.1-1.1-1.0-0.8-1.0-0.60.8
Reaction time trials AUC0.40.71.5-1.2-1.0-0.9-0.8-0.7-0.6-0.8-0.40.7
Run reversals in cocaine runway, females0.70.71.01.01.00.90.90.80.90.70.60.0
Run reversals in cocaine runway, males0.50.50.7-0.4-0.7-0.7-0.8-0.8-0.7-0.8-0.70.7
Latency to leave start box in cocaine runway0.10.20.70.4-0.1-0.3-0.2-0.3-0.2-0.3-0.50.8
Latency to leave start box in cocaine runway, F1.11.22.8-0.1-0.9-1.2-1.0-1.2-1.0-1.0-1.21.7
Latency to leave start box in cocaine runway, M0.50.40.60.60.80.80.70.70.70.70.5-0.4
Std. dev. time between licks in bursts0.20.30.8-0.40.10.40.30.40.70.90.7-0.1
Total sessions with >9 infusions0.10.10.50.70.20.00.0-0.1-0.1-0.2-0.4-0.1
Short access day 1 total inactive lever presses0.20.20.6-0.1-0.4-0.3-0.5-0.4-0.5-0.5-0.5-0.8
Short access day 10 total inactive lever presses0.61.52.5-1.3-1.6-1.5-1.5-1.4-1.2-1.0-1.0-0.0
Short access day 1 total infusions0.30.52.01.40.80.60.50.40.30.2-0.1-0.7
Short access day 10 total infusions1.11.52.00.81.31.31.21.21.31.21.0-1.4
Short access total infusions0.60.72.21.51.10.80.80.70.60.40.2-1.0
Short access day 1 locomotion0.50.71.10.61.01.10.90.90.70.70.7-0.7
Short access day 10 total locomotion0.00.00.3-0.10.00.2-0.00.10.20.20.0-0.5
Short access total locomotion0.91.11.61.11.21.21.11.11.11.00.7-0.8
One hour access (0.3 mA shock)1.92.23.4-1.8-1.8-1.6-1.6-1.5-1.5-1.2-1.01.3
Compulsive drug intake0.40.52.31.50.60.30.20.10.0-0.1-0.51.3
One hour access (shock baseline)0.50.74.1-2.0-1.1-0.6-0.7-0.4-0.4-0.20.3-0.2
Social response proportion2.22.56.5-2.6-2.0-1.8-1.5-1.4-1.4-1.0-0.60.7
Social responses0.50.74.6-2.1-0.8-0.4-0.3-0.1-0.00.40.7-0.0
Social time0.30.52.71.70.70.40.30.1-0.1-0.3-0.50.4
Soleus weight0.51.45.6-2.4-0.30.30.50.80.91.11.8-0.6
Bone: stiffness0.10.21.4-1.2-0.5-0.2-0.2-0.1-0.00.10.4-0.4
Tibialis anterior weight1.13.924.9-5.0-1.7-0.7-0.30.20.51.02.1-0.8
Time to tail flick, vehicle, before self-admin0.70.73.92.00.90.50.80.50.60.40.20.1
Time to tail flick, vehicle, after self-admin0.00.00.00.10.0-0.00.10.0-0.1-0.20.00.0
Time to tail flick, test, before self-admin2.02.13.4-0.4-1.8-1.8-1.7-1.6-1.4-1.1-1.21.4
Time to tail flick, test, after self-admin0.10.10.60.80.50.20.40.20.30.2-0.0-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.40.20.30.20.30.20.10.3-0.2
Delta time to tail flick, test, before/after SA1.21.32.30.41.51.31.31.21.10.90.8-1.1
Tibia length3.39.113.9-3.7-3.7-3.5-3.2-3.1-3.0-2.6-2.01.6
Ambulatory time before self-admin1.42.12.80.81.51.71.61.61.51.61.5-0.7
Ambulatory time after self-admin0.70.81.20.70.90.91.01.01.01.01.10.1
Bone: tissue strength0.40.40.6-0.2-0.7-0.7-0.7-0.8-0.6-0.4-0.70.5
Total heroin consumption3.64.26.21.32.52.42.42.32.11.71.9-1.3
Bone: trabecular number0.50.95.7-2.4-0.8-0.2-0.10.20.30.71.10.0
Bone: trabecular spacing0.81.15.62.41.30.90.80.60.5-0.1-0.3-0.7
Bone: trabecular thickness1.41.75.5-2.3-0.20.40.60.91.11.61.9-0.9
Bone: trabecular tissue density0.81.22.00.21.01.11.11.11.21.41.2-0.9
Water consumed over 24 hours4.05.37.3-2.6-2.7-2.4-2.6-2.4-2.4-2.3-1.91.1
Number of responses in last shaping day0.20.20.40.60.60.50.40.40.40.30.1-0.1