Hub : Genes

Ctu1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr1_103252043_103254866 0.05 0.03 1.0e-03 0.01 0.02 0.02 0.02 1.6e-02 8.0e-03 8.2e-03 1.0e-02
2 PL mRNA stability Ctu1 0.12 0.06 6.2e-09 0.08 0.08 0.06 0.09 1.8e-09 2.3e-09 1.3e-07 1.5e-09
3 NAcc mRNA stability Ctu1 0.08 0.04 2.3e-12 0.07 0.08 0.07 0.07 3.7e-11 1.2e-11 3.5e-11 2.5e-11
4 Adipose gene expression Ctu1 0.06 0.03 2.6e-05 0.04 0.02 0.02 0.02 8.6e-05 1.1e-03 1.1e-03 9.8e-04
5 NAcc gene expression Ctu1 0.02 0.01 6.9e-03 0.02 0.01 0 0.01 8.8e-04 1.9e-02 2.6e-01 3.1e-03
6 IC gene expression Ctu1 0.18 0.11 4.9e-04 0.11 0.07 0.1 0.07 2.0e-05 5.7e-04 8.0e-05 6.0e-04
7 OFC gene expression Ctu1 0.26 0.13 1.2e-03 0.14 0.09 0.09 0.06 3.6e-04 3.4e-03 3.6e-03 1.5e-02
8 Liver gene expression Ctu1 0.04 0.03 7.9e-04 0.01 0.01 0 0.01 2.3e-02 6.7e-03 1.6e-01 3.8e-02
9 Adipose isoform ratio NM_001106251.1 0.04 0.02 1.1e-03 0.02 0.01 0.01 0.01 5.3e-03 1.9e-02 4.0e-02 3.6e-02
10 Adipose isoform ratio XM_006228984.5 0.04 0.02 1.1e-03 0.02 0.01 0.01 0.01 5.2e-03 2.2e-02 4.3e-02 4.4e-02
11 Liver isoform ratio XM_006228984.5 0.03 0.02 7.1e-03 -0 0 0 0 4.1e-01 9.5e-02 1.5e-01 3.1e-01
12 Liver isoform ratio NM_001106251.1 0.03 0.02 4.3e-03 -0 0.01 0 0 3.9e-01 7.0e-02 7.5e-02 2.2e-01
13 Brain mRNA stability Ctu1 0.16 0.06 7.6e-12 0.09 0.13 0.14 0.12 4.4e-09 1.9e-12 1.3e-12 1.5e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.30.50.9-0.40.60.60.40.90.60.5-0.91.0-1.00.7-0.70.3
Area under the delay curve1.01.12.10.9-0.8-0.4-1.1-1.0-0.90.21.0-1.51.5-1.41.5-0.8
BMI with tail0.51.83.0-1.01.21.41.41.51.30.6-1.51.7-1.71.4-1.40.6
BMI without tail0.10.21.20.30.20.70.20.10.31.1-0.80.4-0.4-0.10.10.2
Body weight0.41.64.32.1-1.7-1.0-1.7-1.3-1.70.50.5-1.01.0-1.01.0-1.1
Weight adjusted by age0.10.20.6-0.4-0.0-0.10.30.30.1-0.70.00.6-0.60.8-0.70.1
Bone surface0.91.77.0-0.31.31.61.11.41.22.6-1.61.0-1.0-0.50.40.9
Bone volume0.40.73.20.10.70.80.50.90.71.8-1.20.9-0.9-0.10.00.5
Breakpoint value in progressive ratio session0.40.51.90.10.40.80.60.70.51.4-1.20.8-0.80.3-0.40.5
Number of licking bursts0.30.40.9-0.80.80.70.60.60.50.40.3-0.50.5-1.00.90.6
Context. condit. distance diff. score5.26.311.6-2.93.43.32.83.03.12.4-2.21.5-1.50.1-0.23.1
Locomotion velocity, session 11.81.95.8-2.41.61.41.51.81.4-1.0-0.30.8-0.81.3-1.21.4
Locomotion distance, session 13.34.26.1-2.42.42.02.42.52.40.4-1.82.2-2.21.9-1.91.3
Locomotion velocity, session 20.91.02.5-1.61.10.91.21.31.1-0.8-0.20.7-0.71.1-1.00.6
Locomotion distance, session 20.60.82.0-1.11.21.11.40.81.10.6-0.70.7-0.70.4-0.40.6
Locomotion velocity, session 30.70.83.3-1.81.31.01.01.11.0-0.30.10.2-0.20.2-0.11.1
Locomotion distance, session 30.30.30.7-0.30.3-0.00.30.40.4-0.3-0.20.7-0.70.8-0.8-0.6
Stereotopy head waving bouts, day 32.02.44.1-2.01.91.91.71.51.80.6-1.51.3-1.31.0-1.01.8
Stereotopy head waving duration, day 32.22.65.0-2.12.02.21.61.61.80.9-1.61.1-1.10.8-0.82.2
Locomotion velocity, session 70.70.82.0-0.1-0.2-0.3-0.6-0.7-0.5-0.21.2-1.41.4-1.21.30.0
Locomotion distance, session 70.20.31.4-0.30.60.60.20.40.41.2-0.3-0.10.1-0.60.60.3
Stereotopy head waving bouts, day 70.30.30.8-0.3-0.0-0.2-0.2-0.7-0.3-0.40.9-0.80.8-0.70.70.1
Stereotopy head waving duration, day 70.20.20.7-0.3-0.0-0.2-0.2-0.7-0.2-0.70.8-0.70.7-0.50.5-0.0
Locomotion velocity, session 83.44.110.5-3.22.41.82.52.42.3-1.2-0.51.5-1.51.8-1.81.7
Locomotion distance, session 86.29.016.6-3.94.13.73.83.53.81.7-2.32.2-2.21.2-1.33.1
Degree of sensitization distance0.20.30.7-0.30.40.50.30.10.30.9-0.1-0.40.4-0.70.70.8
Degree of sensitization stereotypy1.41.52.90.7-0.9-1.1-1.0-1.6-1.1-0.81.7-1.51.5-1.21.2-0.9
Conditioned locomotion0.10.10.3-0.0-0.1-0.2-0.40.1-0.2-0.10.3-0.40.4-0.50.50.2
Cocaine response after cond. corrected1.72.14.61.3-1.7-2.1-1.6-1.5-1.4-2.11.3-0.40.40.6-0.6-2.0
Cocaine response after cond. not corrected1.61.94.31.2-1.5-1.9-1.4-1.5-1.3-2.01.4-0.50.50.3-0.3-2.1
Cocaine response before conditioning0.20.20.5-0.50.50.70.60.30.30.30.2-0.30.3-0.60.60.3
Saline control response0.20.30.60.5-0.2-0.0-0.5-0.4-0.30.80.2-0.60.6-0.80.8-0.1
Bone: connectivity density1.11.73.2-1.31.71.81.31.61.51.5-1.41.1-1.10.1-0.21.3
Bone: cortical apparent density0.81.12.31.4-1.3-1.0-1.5-1.3-1.30.10.4-1.01.0-0.80.8-0.7
Bone: cortical area0.40.61.91.4-0.7-0.7-0.9-0.5-0.70.90.2-0.30.3-0.80.7-1.1
Bone: cortical porosity0.30.42.1-1.00.2-0.30.30.10.0-1.41.0-0.30.30.3-0.30.3
Bone: cortical porosity0.30.41.6-1.30.50.10.60.40.3-1.10.9-0.10.10.2-0.20.4
Bone: cortical thickness0.50.91.61.0-1.1-1.3-1.2-1.0-1.1-0.50.9-0.70.7-0.40.3-1.3
Bone: cortical thickness0.10.10.3-0.20.30.10.2-0.00.40.0-0.30.5-0.50.5-0.5-0.2
Bone: cortical tissue density0.81.12.31.4-1.3-1.0-1.5-1.3-1.30.10.5-1.01.0-0.90.9-0.7
Condit. Reinf. active minus inactive responses0.10.10.40.4-0.10.1-0.1-0.6-0.10.3-0.2-0.20.2-0.40.4-0.3
Condit. Reinf. active-inactive response ratio0.00.00.20.3-0.1-0.0-0.0-0.4-0.10.00.0-0.20.2-0.20.3-0.3
Condit. Reinf. active responses0.30.40.90.9-0.4-0.0-0.7-0.9-0.50.60.0-0.60.6-0.90.9-0.5
Condit. Reinf. inactive responses0.50.61.31.1-0.7-0.2-1.1-0.8-0.80.80.1-0.60.6-1.01.0-0.5
Incentive salience index mean0.00.00.20.3-0.10.2-0.2-0.4-0.10.1-0.2-0.10.1-0.10.1-0.2
Condit. Reinf. lever presses0.60.81.91.1-1.2-0.8-1.4-1.0-1.1-0.50.6-0.80.8-0.30.4-1.1
Condit. Reinf. active minus inactive responses0.91.13.70.8-0.30.2-0.7-0.5-0.51.60.4-1.31.3-1.91.9-0.2
Condit. Reinf. active-inactive response ratio0.30.30.80.2-0.3-0.5-0.3-0.6-0.4-0.20.9-0.70.7-0.80.8-0.3
Condit. Reinf. active responses1.11.56.11.1-0.20.6-0.8-0.2-0.52.5-0.3-1.21.2-2.02.00.0
Condit. Reinf. inactive responses0.81.07.61.00.21.0-0.20.60.22.8-1.40.1-0.1-0.80.80.3
Condit. Reinf. lever presses1.21.68.51.00.21.2-0.30.3-0.02.9-1.0-0.80.8-1.91.90.6
Condit. Reinf. lever reinforcers received1.11.67.01.2-0.20.6-0.8-0.1-0.42.7-0.4-1.11.1-2.12.0-0.0
Conditioned reinforcement - actives0.10.20.7-0.30.2-0.00.20.20.2-0.5-0.20.7-0.70.9-0.80.0
Conditioned reinforcement - inactives0.30.41.20.3-0.10.5-0.3-0.3-0.40.70.2-0.90.9-1.11.10.3
Conditioned locomotion0.81.01.7-1.01.00.70.91.11.0-0.2-0.81.3-1.31.3-1.30.3
Patch foraging indifference point 0 sec2.64.816.41.5-0.60.8-1.1-1.3-1.13.10.5-2.52.5-4.14.10.6
Patch foraging indifference point AUC0.91.33.6-1.21.21.51.11.41.20.8-1.40.8-0.80.4-0.51.9
Delay disc. indifference point, 0s delay0.30.30.7-0.50.80.80.80.70.70.6-0.50.4-0.40.0-0.10.2
Delay disc. indifference point, 16s delay1.71.93.21.1-1.2-0.9-1.5-1.2-1.4-0.51.5-1.81.8-1.61.6-1.3
Delay disc. indifference point, 2s delay1.51.63.8-1.41.62.01.41.71.51.3-1.20.7-0.70.1-0.11.3
Delay disc. indifference point, 24s delay0.40.41.50.00.20.3-0.2-0.2-0.00.10.6-1.01.0-1.21.2-0.2
Delay disc. indifference point, 4s delay0.70.81.40.9-0.8-0.4-0.8-0.9-0.90.60.5-1.11.1-1.21.2-0.4
Delay disc. indifference point, 8s delay2.32.74.11.7-1.6-1.3-1.9-1.9-1.7-0.21.6-2.02.0-1.71.7-1.3
Indifference point function ln k0.20.41.40.7-0.1-0.1-0.1-0.7-0.11.20.0-0.00.0-0.90.8-0.9
Indifference point function log k0.20.41.40.7-0.1-0.1-0.1-0.7-0.11.20.0-0.00.0-0.90.8-0.9
Patch foraging total patch changes 0 sec2.44.615.51.4-0.60.6-1.0-1.2-1.12.90.6-2.52.5-3.93.90.6
Patch foraging total patch changes 12 sec0.40.62.50.40.11.0-0.10.50.01.6-0.9-0.10.1-0.90.90.9
Patch foraging total patch changes 18 sec1.93.09.0-1.21.62.51.11.11.13.0-1.1-0.60.6-2.02.02.5
Patch foraging total patch changes 24 sec1.93.37.0-1.31.92.41.72.01.82.6-2.41.2-1.20.1-0.22.2
Patch foraging total patch changes 6 sec0.81.23.90.40.01.0-0.30.3-0.31.9-0.3-1.01.0-1.92.00.9
Patch foraging time to switch 0 sec0.81.79.8-0.2-1.1-1.5-0.9-0.8-1.0-3.11.5-0.50.51.3-1.2-0.9
Patch foraging water rate 0 sec1.02.18.10.10.81.40.40.30.42.8-0.4-0.90.9-2.52.51.0
Patch foraging water rate 12 sec0.40.84.0-0.30.91.00.50.30.62.0-0.7-0.00.0-1.31.20.9
Patch foraging water rate 18 sec0.20.31.60.30.30.30.4-0.10.11.3-0.1-0.40.4-1.01.00.3
Patch foraging water rate 24 sec0.60.82.0-0.61.21.01.10.71.21.4-0.81.1-1.1-0.0-0.10.1
Patch foraging water rate 6 sec1.11.69.30.11.21.40.70.61.03.0-1.30.4-0.4-1.31.20.9
Seeking ratio, delayed vs. immediate footshock0.70.82.4-0.80.30.20.60.70.5-1.0-0.41.2-1.21.5-1.50.2
Distance traveled before self-admin1.01.44.9-0.61.21.51.11.21.22.2-1.70.7-0.70.0-0.11.1
Distance traveled after self-admin0.30.41.2-0.30.20.20.40.40.4-0.3-0.70.8-0.81.1-1.1-0.0
Extensor digitorum longus weight1.97.413.0-3.33.03.03.23.62.90.9-2.52.4-2.42.0-2.03.1
Bone: elastic displacement1.01.13.6-1.91.30.81.51.01.2-0.7-0.20.7-0.70.7-0.71.4
Bone: elastic work0.20.20.6-0.20.30.00.60.30.40.0-0.40.7-0.70.5-0.50.0
Bone: endosteal estimation0.61.44.20.40.81.10.91.31.02.1-1.91.5-1.50.3-0.40.1
Bone: endosteal perimeter0.30.63.30.70.40.70.40.60.51.8-1.20.8-0.8-0.30.2-0.3
Epididymis fat weight0.10.51.6-0.80.20.10.60.70.3-1.1-0.10.4-0.41.2-1.20.3
Delta time in closed arm before/after self-admin0.80.72.10.2-0.7-1.1-0.8-0.8-0.7-1.51.3-0.90.9-0.40.40.5
Delta time in open arm before/after self-admin0.10.10.6-0.10.30.50.20.40.20.8-0.40.2-0.2-0.10.1-0.1
Diff in mean of infusions in LGA sessions0.60.72.3-0.60.81.30.50.90.61.5-0.80.1-0.1-0.70.71.2
Delay discount exponential model param1.01.22.1-1.00.80.51.21.00.9-0.1-1.01.4-1.41.4-1.40.9
Extinction: sum of active levers before priming1.51.64.6-0.10.30.10.70.90.6-0.4-1.42.0-2.02.1-2.2-0.1
Active lever presses in extinction session 61.81.83.1-0.80.80.91.01.41.10.5-1.81.7-1.71.8-1.80.9
Bone: final force0.20.31.21.1-0.6-0.6-0.2-0.5-0.40.4-0.10.2-0.2-0.0-0.0-1.0
Bone: final moment0.30.41.81.4-0.9-0.8-0.5-0.6-0.70.30.1-0.00.0-0.20.2-1.1
Food consumed during 24 hour testing period1.11.53.61.2-0.9-0.7-1.0-1.3-1.10.80.9-1.51.5-1.91.9-0.3
Glucose0.30.53.0-0.4-0.4-0.7-0.0-0.1-0.4-1.71.1-0.40.40.4-0.4-0.1
Heart weight0.30.51.8-0.10.70.70.60.70.71.3-0.80.7-0.7-0.30.30.2
Delay discount hyperbolic model param0.60.71.5-0.70.60.30.90.70.7-0.3-0.71.2-1.21.2-1.20.6
Intermittent access intake day 1-15 change1.42.84.8-1.11.92.01.81.91.82.0-2.21.7-1.70.7-0.81.3
Intermittent access intake escalation1.02.14.2-0.71.61.71.51.61.52.0-2.01.6-1.60.6-0.71.0
Intermittent access intake escalation 20.40.41.80.10.70.70.60.70.51.4-0.90.7-0.7-0.00.00.3
Intermitt. access day 1 inactive lever presses0.31.24.7-0.41.01.80.90.80.72.2-1.40.1-0.1-0.80.81.4
Intermitt. access day 15 inactive lever presses2.14.29.12.4-1.7-0.9-1.9-1.9-2.11.21.2-2.42.4-3.03.0-0.9
Intermitt. access escalation Index0.50.72.60.4-0.7-1.3-0.4-0.4-0.5-1.60.90.2-0.20.8-0.8-0.9
Intermittent access day 1 total infusions1.32.02.91.3-1.5-1.6-1.6-1.6-1.7-0.91.7-1.51.5-1.01.0-1.3
Intermittent access day 15 total infusions0.20.31.20.8-0.2-0.1-0.4-0.3-0.41.1-0.1-0.30.3-0.80.7-0.1
Intermittent access terminal intake (last 3 days)0.10.21.30.40.10.30.00.0-0.01.1-0.3-0.10.1-0.50.50.0
Intermittent access total infusions0.50.61.21.0-0.9-0.9-1.0-0.9-1.1-0.20.6-0.70.7-0.40.4-0.7
Intermittent access day 1 locomotion0.10.20.30.5-0.3-0.2-0.3-0.4-0.50.20.3-0.50.5-0.50.5-0.5
Intermittent access day 15 total locomotion1.01.83.3-1.11.61.81.41.51.51.6-1.71.2-1.20.5-0.51.0
Intermittent access total locomotion0.10.10.4-0.00.30.30.20.30.20.6-0.60.5-0.50.3-0.3-0.1
Intermittent access standard deviation0.00.10.3-0.30.30.50.30.30.10.4-0.40.1-0.10.0-0.00.5
Left kidney weight3.114.227.55.2-4.8-4.4-4.4-4.2-4.5-1.03.2-2.92.9-2.22.2-4.3
Right kidney weight3.314.827.35.2-4.9-4.5-4.6-4.1-4.7-1.23.3-3.13.1-2.32.3-4.5
Cocaine induced anxiety0.40.50.90.8-0.8-1.0-0.6-0.9-0.7-0.50.9-0.60.6-0.40.4-0.7
Post-drug Anxiety0.20.21.6-0.60.1-0.20.2-0.10.1-1.30.6-0.10.10.5-0.50.0
Baseline Anxiety0.91.02.4-1.60.90.60.91.00.8-1.2-0.30.8-0.81.4-1.40.6
Tail length1.87.212.23.5-2.8-2.1-3.1-3.2-2.81.21.5-2.82.8-3.13.1-1.5
Length with tail1.77.314.43.8-3.3-2.7-3.4-3.0-3.20.21.7-2.62.6-2.32.3-2.1
Length without tail0.51.62.51.3-1.4-1.3-1.5-0.9-1.6-0.51.2-1.51.5-1.01.0-1.0
Times rat made contact with spout0.60.72.3-0.10.10.1-0.0-0.2-0.20.80.7-1.01.0-1.51.51.1
Lifetime Intake1.82.23.61.9-1.8-1.7-1.8-1.8-1.9-0.51.3-1.31.3-0.90.9-1.3
Liver weight, left0.20.30.60.4-0.1-0.0-0.20.40.20.4-0.80.8-0.80.8-0.8-0.6
Liver weight, right0.20.30.90.4-0.30.3-0.6-0.1-0.40.70.1-0.90.9-0.91.0-0.0
Locomotor activity0.60.91.81.3-1.2-0.8-1.1-0.6-1.20.30.8-1.11.1-0.90.9-0.8
Locomotor testing distance0.10.20.50.7-0.5-0.4-0.40.0-0.40.60.2-0.20.2-0.30.3-0.3
Locomotor testing rearing0.20.51.21.1-0.9-0.8-1.0-0.5-0.80.70.3-0.50.5-0.60.5-0.4
Locomotion in novel chamber1.11.32.91.4-1.5-1.7-1.3-1.4-1.3-1.70.8-0.10.10.4-0.4-1.1
Locomotion in novel chamber post-restriction1.01.63.5-0.70.91.01.11.21.10.1-1.71.9-1.91.5-1.60.3
Fecal boli incidents, locomotor time 11.31.93.81.1-1.1-0.9-1.2-1.3-1.40.11.6-2.02.0-1.61.6-0.8
Change in fecal boli incidents, locomotor task0.10.10.6-0.50.10.10.10.10.2-0.70.10.1-0.10.2-0.10.8
Time >=10cm from walls, locomotor time 13.33.57.32.7-2.2-2.3-2.4-2.3-2.1-0.61.4-1.41.4-1.11.1-1.8
Bouts of movement, locomotor time 12.12.45.01.8-2.2-2.0-1.9-1.6-2.0-1.31.4-1.11.1-0.30.3-1.6
Total resting periods, locomotor time 11.82.14.31.5-2.1-1.8-1.6-1.5-1.8-1.41.4-1.11.1-0.30.3-1.3
Rest time, locomotor task time 10.10.10.3-0.3-0.1-0.10.00.1-0.4-0.50.5-0.50.5-0.20.20.5
Distance moved, locomotor task time 13.45.07.7-2.02.22.02.32.42.60.5-2.52.8-2.82.2-2.21.7
Vertical activity count, locomotor time 10.10.10.50.50.00.2-0.40.10.20.7-0.70.1-0.1-0.20.20.2
Time >=10cm from walls, locomotor time 20.71.01.71.0-1.0-1.2-1.1-1.2-1.1-1.01.3-1.01.0-0.60.6-1.0
Bouts of movement, locomotor time 20.10.10.60.6-0.20.3-0.2-0.0-0.20.7-0.70.1-0.10.00.00.4
Total resting periods, locomotor time 20.10.10.60.7-0.30.2-0.3-0.1-0.30.5-0.70.1-0.10.2-0.10.2
Rest time, locomotor task time 20.30.40.80.7-0.6-0.8-0.9-0.8-0.6-0.80.5-0.40.40.1-0.1-0.6
Distance moved, locomotor task time 21.41.72.5-1.41.51.41.61.41.50.8-1.41.4-1.40.8-0.81.1
Vertical activity count, locomotor time 20.30.40.90.4-0.4-0.2-0.7-0.1-0.50.30.6-0.90.9-0.90.9-0.3
Light reinforcement 10.41.13.9-0.50.91.70.70.90.72.0-1.3-0.00.0-0.70.71.3
Light reinforcement 20.30.52.3-1.20.80.90.90.40.6-0.3-0.30.1-0.10.2-0.11.5
Bone: marrow area0.71.44.30.30.81.10.91.31.02.1-1.91.6-1.60.3-0.40.1
Bone: maximum diameter0.51.03.01.7-0.9-0.8-1.0-0.7-0.81.00.3-0.40.4-1.11.1-1.6
Bone: maximum force0.40.71.80.70.10.10.50.50.41.1-1.11.3-1.30.7-0.7-0.8
Bone: maximum moment0.30.61.31.0-0.1-0.10.30.40.21.0-1.01.1-1.10.5-0.6-0.9
Mean time between licks in bursts0.00.10.8-0.30.0-0.10.1-0.1-0.1-0.90.6-0.20.20.1-0.0-0.3
Mean num. licks in bursts0.10.10.30.3-0.2-0.1-0.1-0.3-0.00.4-0.40.3-0.30.2-0.30.5
Cd content in liver1.21.32.21.4-1.2-1.0-1.5-1.0-1.30.70.7-1.21.2-1.41.4-0.3
Co content in liver0.30.30.90.4-0.7-0.9-0.4-0.3-0.6-0.80.8-0.30.30.1-0.2-0.3
Cu content in liver1.11.42.0-1.01.21.41.21.41.30.9-1.41.2-1.20.9-0.90.9
Fe content in liver1.92.35.3-1.61.82.31.51.51.61.8-1.60.5-0.5-0.30.32.2
K content in liver0.50.51.50.1-0.3-0.1-0.4-0.4-0.5-0.20.8-1.21.2-1.01.0-0.6
Mg content in liver0.80.81.70.5-0.7-0.6-0.9-1.0-0.9-0.71.2-1.31.3-0.80.9-0.7
Mn content in liver0.10.10.8-0.2-0.1-0.5-0.2-0.4-0.1-0.90.50.1-0.10.4-0.4-0.0
Na content in liver0.00.00.2-0.20.1-0.20.30.10.2-0.20.20.2-0.20.1-0.2-0.5
Rb content in liver1.61.94.2-1.41.72.11.41.41.41.9-0.80.1-0.1-1.00.91.9
Se content in liver0.10.10.5-0.10.30.60.10.70.20.5-0.4-0.00.0-0.00.10.7
Sr content in liver0.20.20.7-0.10.40.40.40.50.40.8-0.50.2-0.2-0.40.30.6
Zn content in liver0.40.40.90.6-0.50.0-0.5-0.1-0.60.50.3-0.90.9-0.90.9-0.4
Bone: minimum diameter0.91.74.8-0.11.21.31.31.71.32.2-1.91.5-1.50.3-0.40.2
Time in familiar zone, hab. session 10.10.10.30.4-0.10.0-0.40.3-0.10.5-0.0-0.20.2-0.50.50.1
Time in novel zone, hab. session 10.10.10.3-0.40.20.20.5-0.30.1-0.40.20.0-0.00.2-0.10.1
Total zone transitions, hab. session 10.50.71.6-1.31.00.51.10.51.0-0.5-0.10.8-0.80.9-0.90.2
Total locomotion distance, hab. session 10.20.30.7-0.80.80.70.80.10.80.2-0.40.6-0.60.3-0.30.5
Locomotion velocity, hab. session 10.00.10.2-0.50.30.20.3-0.30.3-0.20.00.2-0.20.2-0.20.2
Time in familiar zone, hab. session 20.80.95.51.2-0.10.7-0.60.2-0.12.3-1.0-0.20.2-1.21.2-0.0
Time in novel zone, hab. session 21.01.02.5-1.61.00.61.30.71.0-0.8-0.40.9-0.91.2-1.20.8
Total zone transitions, hab. session 20.91.22.6-1.41.61.41.61.11.51.0-0.70.8-0.80.1-0.10.6
Total locomotion distance, hab. session 20.91.22.5-1.01.41.61.40.61.41.5-1.20.7-0.7-0.10.01.0
Locomotion velocity, hab. session 20.40.51.2-0.81.01.10.90.20.90.9-0.60.2-0.2-0.30.30.7
Novel to familiar place preference ratio1.21.32.60.4-0.6-0.8-0.7-1.3-0.9-0.11.6-1.51.5-1.61.6-0.5
Novelty place preference0.90.92.30.2-0.4-0.5-0.4-1.1-0.60.01.4-1.31.3-1.51.5-0.2
Time in novel zone, NPP test0.80.92.60.2-0.2-0.4-0.3-1.0-0.50.31.2-1.21.2-1.61.6-0.1
Total zone transitions, NPP test1.92.84.7-1.81.61.02.01.41.8-0.5-1.02.1-2.12.1-2.20.4
Total locomotion distance, NPP test3.64.96.8-2.22.42.42.61.92.60.9-2.42.5-2.52.0-2.01.7
Locomotion velocity, NPP test2.73.95.3-2.12.11.92.31.72.20.3-1.92.3-2.32.1-2.11.2
Intraocular pressure4.15.910.72.9-3.2-3.3-2.7-3.0-2.9-2.22.1-1.41.4-0.20.2-3.1
Delta distance traveled before/after self-admin0.60.61.80.7-0.9-1.0-0.8-0.9-0.8-1.40.9-0.30.30.1-0.0-1.1
Delta ambulatory time before/after self-admin0.20.21.10.0-0.3-0.3-0.3-0.4-0.4-1.00.7-0.30.3-0.00.1-0.1
Parametrial fat weight1.02.26.00.8-1.8-1.5-1.9-1.3-1.9-2.41.8-1.41.40.10.1-0.9
Pavlov. Cond. lever latency0.50.72.0-0.81.01.00.70.90.81.1-0.70.3-0.3-0.30.31.4
Pavlov. Cond. magazine entry latency0.50.72.01.0-0.5-0.7-0.7-1.4-0.60.30.6-0.70.7-1.11.0-1.0
Pavlov. Cond. change in total contacts0.40.51.30.6-0.6-0.7-0.6-1.1-0.6-0.60.7-0.50.5-0.30.4-1.0
Pavlov. Cond. index score1.31.73.31.4-1.4-1.5-1.3-1.8-1.3-0.91.4-1.11.1-0.70.7-1.7
Pavlov. Cond. latency score1.31.63.41.5-1.4-1.5-1.3-1.8-1.4-0.91.3-0.90.9-0.50.5-1.8
Pavlov. Cond. lever contacts0.91.02.71.1-1.2-1.2-1.1-1.2-1.1-1.01.0-0.60.6-0.10.1-1.7
Pavlov. Cond. magazine entry number0.60.72.1-0.80.70.90.71.50.70.3-1.00.7-0.70.8-0.81.0
Pavlov. Cond. intertrial magazine entries0.40.41.1-1.10.90.80.80.80.8-0.0-0.30.4-0.40.4-0.40.9
Pavlov. Cond. lever-magazine prob. diff.0.70.92.00.7-0.8-1.0-0.8-1.4-0.8-0.71.2-0.90.9-0.70.6-1.2
Pavlov. Cond. response bias1.01.22.81.0-1.0-1.2-1.1-1.7-1.1-0.81.3-1.01.0-0.70.7-1.3
Pavlov. Cond. lever latency1.01.46.10.2-1.1-1.7-0.8-1.3-0.9-2.51.4-0.20.20.8-0.8-1.1
Pavlov. Cond. magazine entry latency0.70.93.5-0.20.81.30.70.70.61.9-0.6-0.30.3-1.21.20.8
Pavlov. Cond. change in total contacts0.91.58.41.4-0.00.7-0.3-0.0-0.22.9-0.8-0.60.6-1.91.8-0.1
Pavlov. Cond. index score1.21.68.20.11.01.70.81.10.72.9-1.2-0.20.2-1.41.41.0
Pavlov. Cond. latency score1.01.36.1-0.11.01.60.81.10.82.5-1.0-0.10.1-1.21.20.9
Pavlov. Cond. lever contacts1.01.46.7-0.11.01.60.81.30.92.6-1.50.4-0.4-0.70.70.9
Pavlov. Cond. magazine entry number1.31.77.40.2-1.2-1.9-0.9-1.4-1.0-2.71.4-0.10.11.1-1.1-1.1
Pavlov. Cond. intertrial magazine entries0.10.21.00.2-0.5-0.3-1.0-0.2-0.6-0.30.3-0.50.5-0.00.0-0.3
Pavlov. Cond. lever-magazine prob. diff.1.11.58.00.20.81.60.61.00.62.8-1.1-0.30.3-1.51.50.9
Pavlov. Cond. response bias1.41.99.90.01.11.90.91.51.03.1-1.70.4-0.4-1.00.91.0
Time in closed arm before self-admin0.20.31.8-0.2-0.1-0.3-0.10.2-0.1-0.70.40.4-0.40.6-0.5-1.4
Time in closed arm after self-admin1.61.72.7-1.41.20.81.41.31.4-0.8-0.81.6-1.61.6-1.60.8
Time in open arm before self-admin0.20.20.80.4-0.20.10.0-0.10.00.2-0.90.5-0.50.5-0.50.4
Time in open arm after self-admin0.00.00.20.20.00.20.00.10.10.4-0.40.1-0.1-0.00.00.0
Bone: periosteal estimation0.30.73.90.90.20.50.20.70.42.0-1.31.0-1.0-0.20.1-0.5
Bone: periosteal perimeter0.10.31.20.70.00.1-0.10.40.11.1-0.60.6-0.6-0.10.0-0.7
Bone: post-yield work0.40.61.60.40.30.30.20.50.50.9-1.11.3-1.30.8-0.8-0.7
Progressive ratio test 1 active lever presses1.92.33.81.9-1.7-1.5-1.8-1.8-1.9-0.21.3-1.51.5-1.31.3-1.4
Progressive ratio test 1 breakpoint1.72.13.41.8-1.6-1.4-1.7-1.7-1.7-0.11.2-1.41.4-1.31.3-1.3
Progressive ratio test 1 inactive lever presses1.31.95.02.2-1.5-1.0-1.5-1.4-1.51.00.4-1.11.1-1.61.6-1.2
Progressive ratio test 2 active lever presses1.01.21.91.3-1.2-1.1-1.3-1.3-1.40.11.0-1.11.1-1.01.0-0.6
Progressive ratio test 2 breakpoint1.41.62.51.5-1.4-1.3-1.5-1.5-1.60.01.1-1.31.3-1.21.2-0.8
Progressive ratio test 2 inactive lever presses0.30.50.90.9-0.6-0.3-0.7-0.7-0.80.30.5-0.70.7-0.90.9-0.6
Incentive Sensitization - Responses0.10.10.50.4-0.20.0-0.4-0.3-0.20.7-0.1-0.40.4-0.50.50.3
Incentive Sensitization - Breakpoint0.10.20.50.4-0.2-0.0-0.4-0.4-0.30.7-0.0-0.40.4-0.60.60.3
Sum of active levers in priming session hrs 5-62.62.56.7-1.01.82.11.71.61.62.6-2.01.0-1.00.1-0.11.7
Progressive ratio0.71.12.70.6-0.5-0.1-0.9-0.9-0.71.00.6-1.51.5-1.61.60.3
Food seeking constrained by brief footshock0.50.61.41.2-1.0-0.9-1.0-1.0-0.9-0.10.4-0.70.7-0.40.4-0.9
Seeking ratio, punishment vs. effort0.50.82.20.3-0.2-0.50.20.20.0-1.1-0.51.2-1.21.5-1.5-1.0
Retroperitoneal fat weight0.41.53.20.9-1.7-1.4-1.6-1.0-1.7-1.81.2-1.31.3-0.00.1-0.3
Reaction time number correct2.44.56.6-2.02.31.92.52.22.41.0-2.22.6-2.61.9-2.01.4
Reaction time mean minus median0.41.04.1-0.10.81.20.70.90.92.0-1.50.7-0.7-0.20.10.7
Reaction time mean minus median AUC0.30.61.6-0.40.71.00.60.80.91.0-1.30.9-0.90.5-0.50.5
Reaction time num false alarms1.21.76.5-0.61.61.91.11.31.32.5-1.00.3-0.3-1.31.20.7
Reaction time num false alarms AUC0.71.13.8-0.10.91.20.40.60.52.0-0.1-0.60.6-1.81.80.2
Reaction time trials correct on left2.44.56.6-2.02.31.92.52.22.41.0-2.22.6-2.61.9-2.01.4
Reaction time trials on left2.14.06.0-1.82.11.82.32.02.31.0-2.12.4-2.41.8-1.91.3
Reaction time mean0.71.12.41.6-1.3-0.9-1.3-1.0-1.20.70.4-1.01.0-1.11.0-0.5
Reaction time mean AUC0.61.02.01.4-1.3-1.0-1.2-1.0-1.20.40.5-1.01.0-1.00.9-0.4
Median of all reaction times1.62.33.71.9-1.8-1.5-1.8-1.6-1.80.21.1-1.61.6-1.41.4-0.7
Reaction time omissions1.92.84.62.0-2.0-1.9-2.1-2.1-2.0-0.81.5-1.51.5-0.80.8-1.5
Reaction time false alarm rate1.01.45.40.6-0.10.3-0.5-0.3-0.51.20.8-1.51.5-2.32.3-0.3
Reaction time premature initiation rate1.52.13.01.2-1.6-1.5-1.5-1.7-1.6-1.21.7-1.71.7-1.01.0-0.9
Reaction time premature initiations0.10.20.40.2-0.4-0.6-0.4-0.7-0.4-0.60.6-0.40.40.0-0.0-0.3
Std. dev. reaction times0.20.31.90.7-0.20.2-0.40.0-0.21.4-0.6-0.10.1-0.70.60.2
Reaction time trials completed2.14.06.0-1.82.11.82.32.02.31.0-2.12.4-2.41.8-1.91.3
Reaction time trials AUC2.03.85.6-1.82.11.72.22.02.21.0-2.02.4-2.41.7-1.81.3
Run reversals in cocaine runway, females1.61.62.9-1.21.61.71.61.41.61.0-1.51.2-1.20.4-0.40.9
Run reversals in cocaine runway, males0.50.50.8-0.50.40.60.40.90.50.1-0.90.9-0.90.8-0.80.6
Latency to leave start box in cocaine runway6.57.411.2-2.73.23.33.23.23.21.9-3.12.7-2.71.6-1.72.1
Latency to leave start box in cocaine runway, F3.54.05.6-2.02.32.42.42.32.41.0-2.32.1-2.11.4-1.41.5
Latency to leave start box in cocaine runway, M3.53.25.4-1.82.32.32.12.12.11.9-1.91.5-1.50.6-0.61.6
Std. dev. time between licks in bursts0.30.41.60.5-0.10.1-0.3-0.6-0.30.60.5-0.60.6-1.21.3-0.3
Total sessions with >9 infusions5.06.18.52.7-2.8-2.6-2.9-2.9-2.9-0.92.5-2.52.5-2.02.0-2.2
Short access day 1 total inactive lever presses0.81.12.11.0-0.9-0.7-1.0-1.0-1.10.30.9-1.31.3-1.41.4-0.3
Short access day 10 total inactive lever presses1.02.45.6-1.31.92.41.81.81.72.0-1.60.9-0.9-0.20.21.6
Short access day 1 total infusions2.43.24.62.1-2.1-2.1-2.1-2.2-2.1-1.01.8-1.61.6-1.21.2-1.6
Short access day 10 total infusions3.84.97.12.6-2.5-2.4-2.5-2.5-2.7-0.82.2-2.02.0-1.61.6-2.3
Short access total infusions5.36.810.33.2-3.2-3.1-3.1-3.1-3.2-1.42.4-2.22.2-1.41.5-2.5
Short access day 1 locomotion1.41.73.81.9-1.4-1.1-1.5-1.5-1.50.70.7-1.11.1-1.41.4-1.2
Short access day 10 total locomotion0.10.20.6-0.60.0-0.1-0.1-0.1-0.3-0.70.8-0.60.6-0.20.10.0
Short access total locomotion1.72.12.91.3-1.4-1.3-1.6-1.6-1.7-0.41.5-1.71.7-1.41.4-1.1
One hour access (0.3 mA shock)0.20.20.80.10.20.5-0.0-0.1-0.10.9-0.2-0.40.4-0.70.70.3
Compulsive drug intake0.00.00.10.1-0.3-0.2-0.1-0.3-0.2-0.20.1-0.20.2-0.10.20.3
One hour access (shock baseline)0.10.10.30.4-0.10.0-0.3-0.2-0.30.5-0.0-0.30.3-0.40.4-0.3
Social response proportion2.73.05.81.6-1.7-1.8-1.8-2.4-1.9-0.72.0-1.91.9-1.61.6-1.1
Social responses1.41.83.01.2-1.2-1.0-1.2-1.7-1.4-0.21.5-1.61.6-1.41.5-0.9
Social time0.40.61.4-0.60.91.20.60.70.81.1-1.00.4-0.40.2-0.20.9
Soleus weight1.02.96.1-2.32.32.32.52.02.11.0-1.31.1-1.10.5-0.51.5
Bone: stiffness0.40.61.50.10.50.50.90.70.71.0-1.11.2-1.20.6-0.7-0.2
Tibialis anterior weight0.31.02.0-1.21.00.91.31.41.10.1-0.71.0-1.00.8-0.81.0
Time to tail flick, vehicle, before self-admin1.51.62.4-1.51.21.01.31.51.1-0.1-1.01.3-1.31.4-1.41.4
Time to tail flick, vehicle, after self-admin1.82.43.3-1.61.71.81.71.81.70.9-1.71.5-1.50.9-1.01.6
Time to tail flick, test, before self-admin0.30.30.7-0.70.70.30.70.50.8-0.3-0.10.5-0.50.4-0.40.5
Time to tail flick, test, after self-admin1.31.32.6-1.31.51.51.61.21.50.6-1.10.9-0.90.5-0.41.0
Delta time to tail flick, vehicle, before/after SA0.00.00.3-0.10.10.10.0-0.00.0-0.20.2-0.10.1-0.00.0-0.5
Delta time to tail flick, test, before/after SA0.00.10.1-0.20.20.40.30.20.20.3-0.40.1-0.1-0.00.10.1
Tibia length2.87.720.04.5-3.5-2.8-3.5-3.1-3.20.51.4-2.02.0-1.91.9-3.2
Ambulatory time before self-admin0.50.83.6-0.20.71.10.70.90.71.9-1.50.5-0.50.1-0.10.7
Ambulatory time after self-admin0.10.10.3-0.20.20.40.30.30.20.2-0.60.2-0.20.3-0.30.2
Bone: tissue strength0.30.30.70.6-0.6-0.8-0.3-0.6-0.6-0.50.6-0.40.4-0.10.1-0.5
Total heroin consumption0.60.61.6-0.80.91.20.80.90.51.2-0.80.3-0.30.0-0.01.2
Bone: trabecular number0.50.91.8-0.60.80.80.61.20.90.6-1.21.3-1.30.9-1.00.2
Bone: trabecular spacing0.60.81.41.0-1.0-1.1-0.7-1.1-0.9-0.90.9-0.70.7-0.20.2-1.2
Bone: trabecular thickness0.10.10.30.3-0.1-0.0-0.20.30.00.4-0.50.5-0.50.2-0.20.1
Bone: trabecular tissue density0.50.82.21.5-0.9-0.5-1.1-0.6-0.91.1-0.1-0.60.6-1.21.1-0.3
Water consumed over 24 hours0.71.02.4-1.01.01.10.80.40.61.10.1-0.60.6-1.41.41.5
Number of responses in last shaping day1.01.11.81.2-1.1-1.2-1.1-1.1-1.3-0.61.2-0.90.9-0.91.0-0.7