Hub : Genes

Ctnnbip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Ctnnbip1 0.05 0.03 5.2e-08 0.05 0.05 0.06 0.05 1.3e-08 4.1e-08 7.2e-09 1.1e-07
2 IC mRNA stability Ctnnbip1 0.32 0.14 2.9e-12 0.27 0.28 0.29 0.29 6.9e-12 2.1e-12 1.7e-12 1.8e-12
3 BLA mRNA stability Ctnnbip1 0.05 0.04 7.5e-03 0.01 0.03 -0 0.02 1.0e-01 1.5e-02 5.3e-01 2.9e-02
4 NAcc mRNA stability Ctnnbip1 0.07 0.04 2.1e-13 0.1 0.09 0.08 0.09 3.7e-14 6.8e-13 2.1e-12 3.3e-13
5 pVTA mRNA stability Ctnnbip1 0.16 0.08 0.0e+00 0.22 0.23 0.22 0.23 8.3e-18 1.4e-18 5.3e-18 1.1e-18
6 OFC mRNA stability Ctnnbip1 0.27 0.2 9.0e-03 0.04 0.03 0.05 0.06 3.2e-02 7.0e-02 2.2e-02 1.4e-02
7 Brain mRNA stability Ctnnbip1 0.18 0.09 0.0e+00 0.18 0.21 0.19 0.2 1.7e-16 5.2e-19 1.9e-17 1.5e-18
8 PL mRNA stability Ctnnbip1 0.12 0.08 5.8e-07 0.05 0.06 0.06 0.05 1.6e-06 2.4e-07 3.9e-07 1.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.10.20.30.4-0.40.4-0.4-0.3-0.4-0.4
Area under the delay curve0.40.63.0-1.0-0.30.3-0.40.51.70.10.5
BMI with tail0.10.30.70.60.6-0.60.8-0.7-0.1-0.6-0.5
BMI without tail0.00.10.40.00.2-0.10.6-0.30.3-0.2-0.3
Body weight0.10.30.4-0.7-0.50.6-0.30.50.50.50.3
Weight adjusted by age0.20.61.3-1.2-0.90.9-0.70.80.80.60.2
Bone surface0.10.20.7-0.8-0.40.5-0.40.30.30.3-0.0
Bone volume0.00.10.3-0.5-0.30.3-0.30.20.30.20.0
Breakpoint value in progressive ratio session0.30.60.90.50.9-0.90.9-0.9-0.3-0.9-0.8
Number of licking bursts0.41.32.00.61.3-1.31.2-1.30.2-1.4-1.3
Context. condit. distance diff. score4.75.77.91.82.5-2.62.8-2.6-1.4-2.5-2.5
Locomotion velocity, session 10.30.40.50.60.7-0.70.6-0.7-0.1-0.7-0.7
Locomotion distance, session 10.60.81.40.51.0-0.91.0-1.0-0.2-1.0-1.2
Locomotion velocity, session 21.31.61.90.91.4-1.31.4-1.4-0.5-1.4-1.4
Locomotion distance, session 20.71.01.51.01.1-0.91.0-1.1-0.8-0.9-1.2
Locomotion velocity, session 32.12.43.01.41.7-1.61.4-1.7-1.6-1.5-1.5
Locomotion distance, session 33.54.06.31.02.3-2.02.1-2.2-1.3-2.2-2.5
Stereotopy head waving bouts, day 30.30.41.61.0-0.20.1-0.10.3-1.20.50.6
Stereotopy head waving duration, day 30.70.81.70.2-0.90.9-0.81.0-0.21.21.3
Locomotion velocity, session 70.91.02.51.00.9-0.80.9-1.0-1.6-0.6-0.8
Locomotion distance, session 70.60.81.50.80.9-0.70.8-0.9-1.2-0.6-0.9
Stereotopy head waving bouts, day 71.21.42.51.61.2-1.31.1-1.2-1.2-1.0-0.7
Stereotopy head waving duration, day 70.10.10.30.60.4-0.50.3-0.4-0.1-0.3-0.1
Locomotion velocity, session 84.25.16.41.92.5-2.42.5-2.5-0.8-2.4-2.4
Locomotion distance, session 86.29.011.62.33.3-3.13.4-3.3-1.7-3.1-3.3
Degree of sensitization distance1.01.12.10.0-1.21.0-1.11.1-0.01.31.4
Degree of sensitization stereotypy0.30.30.50.70.6-0.60.5-0.7-0.6-0.5-0.4
Conditioned locomotion3.23.86.20.12.1-2.01.7-2.21.2-2.5-2.5
Cocaine response after cond. corrected1.42.13.0-1.0-1.61.5-1.51.60.51.71.7
Cocaine response after cond. not corrected1.21.73.0-0.4-1.51.3-1.21.5-0.31.71.7
Cocaine response before conditioning0.50.62.21.10.4-0.50.7-0.5-1.5-0.2-0.2
Saline control response0.10.20.4-0.7-0.20.4-0.20.20.60.30.1
Bone: connectivity density0.10.10.3-0.00.4-0.30.5-0.4-0.2-0.4-0.6
Bone: cortical apparent density1.21.92.6-1.5-1.41.6-1.31.51.11.41.1
Bone: cortical area1.42.44.8-2.2-1.41.5-1.51.41.81.11.0
Bone: cortical porosity0.10.10.30.50.3-0.60.3-0.4-0.2-0.4-0.1
Bone: cortical porosity0.20.20.40.60.3-0.50.3-0.4-0.5-0.4-0.1
Bone: cortical thickness0.61.02.2-1.5-0.90.9-1.00.81.20.70.6
Bone: cortical thickness0.10.10.3-0.40.2-0.10.3-0.20.2-0.3-0.6
Bone: cortical tissue density1.11.72.5-1.4-1.31.6-1.21.41.01.41.1
Condit. Reinf. active minus inactive responses0.10.10.50.50.00.2-0.2-0.0-0.70.30.0
Condit. Reinf. active-inactive response ratio2.32.53.6-1.4-1.71.8-1.91.60.81.71.5
Condit. Reinf. active responses1.21.62.81.71.3-1.11.1-1.2-1.4-0.9-1.2
Condit. Reinf. inactive responses7.49.612.03.53.3-3.23.3-3.1-2.6-2.8-2.9
Incentive salience index mean0.70.91.6-0.4-1.01.2-1.21.0-0.11.30.9
Condit. Reinf. lever presses1.21.82.6-1.0-1.41.6-1.51.40.71.51.2
Condit. Reinf. active minus inactive responses1.52.35.52.21.3-1.41.3-1.3-2.4-0.9-0.8
Condit. Reinf. active-inactive response ratio0.60.93.71.60.5-0.60.6-0.5-1.9-0.10.0
Condit. Reinf. active responses1.82.63.31.81.6-1.71.5-1.6-1.7-1.5-1.4
Condit. Reinf. inactive responses0.10.10.3-0.20.3-0.30.1-0.40.3-0.5-0.6
Condit. Reinf. lever presses1.01.41.81.11.3-1.21.0-1.3-1.2-1.2-1.3
Condit. Reinf. lever reinforcers received1.82.53.21.81.6-1.71.5-1.6-1.7-1.4-1.4
Conditioned reinforcement - actives0.41.41.71.21.1-1.31.3-1.2-1.2-1.1-1.0
Conditioned reinforcement - inactives0.20.51.0-0.5-0.80.7-0.90.50.60.71.0
Conditioned locomotion0.81.12.21.40.9-1.20.9-1.0-1.5-0.8-0.5
Patch foraging indifference point 0 sec0.82.23.0-1.1-1.61.7-1.41.70.51.71.7
Patch foraging indifference point AUC0.10.31.40.5-0.20.2-0.40.2-1.20.50.3
Delay disc. indifference point, 0s delay0.00.00.20.40.1-0.10.20.0-0.2-0.10.2
Delay disc. indifference point, 16s delay0.60.84.7-1.4-0.00.0-0.20.12.2-0.4-0.0
Delay disc. indifference point, 2s delay0.10.10.6-0.3-0.00.0-0.10.10.8-0.10.1
Delay disc. indifference point, 24s delay1.62.67.6-2.7-1.11.2-1.11.12.80.60.6
Delay disc. indifference point, 4s delay0.50.61.1-0.8-0.70.6-0.60.81.10.50.8
Delay disc. indifference point, 8s delay0.50.91.6-0.7-0.90.8-0.81.01.30.81.2
Indifference point function ln k0.20.51.6-1.0-0.60.6-0.50.61.30.40.5
Indifference point function log k0.20.51.6-1.0-0.60.6-0.50.61.30.40.5
Patch foraging total patch changes 0 sec0.72.02.7-1.0-1.51.6-1.41.60.41.61.7
Patch foraging total patch changes 12 sec0.81.11.70.0-1.01.0-1.11.1-0.71.31.3
Patch foraging total patch changes 18 sec0.20.50.8-0.3-0.80.7-0.80.8-0.30.90.9
Patch foraging total patch changes 24 sec0.00.20.80.5-0.00.10.20.2-0.90.30.2
Patch foraging total patch changes 6 sec1.42.33.7-0.7-1.61.7-1.61.7-0.41.91.7
Patch foraging time to switch 0 sec0.00.00.10.10.00.20.10.0-0.30.2-0.1
Patch foraging water rate 0 sec0.00.00.10.10.1-0.20.1-0.10.3-0.20.0
Patch foraging water rate 12 sec0.00.10.50.40.1-0.10.1-0.1-0.70.10.0
Patch foraging water rate 18 sec0.10.20.80.50.10.10.10.1-0.90.30.2
Patch foraging water rate 24 sec0.10.10.40.3-0.20.2-0.20.3-0.60.40.3
Patch foraging water rate 6 sec0.10.20.40.60.4-0.40.4-0.2-0.6-0.3-0.2
Seeking ratio, delayed vs. immediate footshock0.00.00.0-0.10.1-0.0-0.1-0.00.1-0.1-0.0
Distance traveled before self-admin1.84.05.51.81.9-1.82.1-1.9-2.3-1.8-2.3
Distance traveled after self-admin0.50.93.01.30.6-0.60.7-0.7-1.7-0.4-0.6
Extensor digitorum longus weight0.93.55.52.31.9-1.71.6-1.9-2.1-1.4-1.7
Bone: elastic displacement3.95.06.52.12.4-2.52.6-2.4-1.1-2.4-2.1
Bone: elastic work2.83.64.52.12.0-2.12.0-2.0-1.5-1.8-1.6
Bone: endosteal estimation0.61.41.8-1.1-1.31.3-1.21.30.51.31.2
Bone: endosteal perimeter0.41.11.4-1.1-1.21.1-1.11.10.61.11.0
Epididymis fat weight1.15.68.2-2.2-2.52.4-2.92.41.62.42.5
Delta time in closed arm before/after self-admin0.40.41.8-1.00.20.10.20.01.4-0.2-0.3
Delta time in open arm before/after self-admin0.40.52.31.2-0.1-0.20.0-0.0-1.50.20.4
Diff in mean of infusions in LGA sessions0.20.30.9-0.70.3-0.30.3-0.31.0-0.5-0.4
Delay discount exponential model param0.60.83.61.20.4-0.40.5-0.6-1.9-0.1-0.5
Extinction: sum of active levers before priming0.71.12.0-0.4-1.20.9-1.31.10.31.21.4
Active lever presses in extinction session 60.10.10.40.60.2-0.10.2-0.1-0.6-0.0-0.1
Bone: final force1.01.61.9-1.3-1.31.4-1.41.31.01.31.2
Bone: final moment0.60.91.1-0.9-1.01.0-1.01.00.71.01.0
Food consumed during 24 hour testing period0.91.77.12.0-0.3-0.0-0.50.1-2.70.91.3
Glucose0.10.10.20.2-0.30.1-0.30.20.30.20.5
Heart weight12.620.438.46.24.5-4.74.5-4.3-4.4-3.8-3.1
Delay discount hyperbolic model param0.50.63.01.00.3-0.30.4-0.5-1.7-0.1-0.5
Intermittent access intake day 1-15 change0.00.20.50.60.3-0.50.5-0.3-0.7-0.3-0.2
Intermittent access intake escalation0.00.20.60.60.2-0.40.6-0.3-0.8-0.3-0.2
Intermittent access intake escalation 21.01.62.11.41.2-1.41.3-1.4-1.2-1.2-1.0
Intermitt. access day 1 inactive lever presses0.00.10.20.1-0.30.3-0.10.3-0.20.40.4
Intermitt. access day 15 inactive lever presses0.21.33.21.41.0-0.91.2-0.9-1.8-0.7-1.0
Intermitt. access escalation Index0.51.51.91.11.3-1.21.4-1.2-0.9-1.2-1.4
Intermittent access day 1 total infusions0.20.51.0-0.5-0.91.0-0.60.7-0.41.00.5
Intermittent access day 15 total infusions0.30.62.00.2-0.80.7-0.30.6-1.41.00.7
Intermittent access terminal intake (last 3 days)0.40.81.3-0.6-1.11.0-0.60.8-0.81.10.7
Intermittent access total infusions1.01.22.0-0.7-1.41.3-0.91.2-0.61.41.0
Intermittent access day 1 locomotion0.71.31.8-1.0-1.31.4-1.01.30.11.31.0
Intermittent access day 15 total locomotion0.10.20.40.0-0.60.5-0.30.5-0.50.60.5
Intermittent access total locomotion0.30.40.7-0.7-0.80.8-0.40.8-0.10.70.5
Intermittent access standard deviation0.00.21.00.60.2-0.30.2-0.4-1.0-0.1-0.1
Left kidney weight0.10.40.70.80.6-0.60.7-0.6-0.8-0.5-0.5
Right kidney weight0.00.10.10.10.2-0.30.1-0.20.3-0.3-0.2
Cocaine induced anxiety0.20.61.6-0.20.8-0.70.4-0.71.3-1.0-0.9
Post-drug Anxiety0.70.81.60.21.0-0.80.9-0.90.5-1.1-1.3
Baseline Anxiety0.10.10.80.2-0.10.10.40.1-0.90.1-0.3
Tail length0.52.75.8-2.4-1.51.6-1.61.32.01.20.9
Length with tail0.62.55.2-2.3-1.51.6-1.61.51.51.31.1
Length without tail0.00.20.3-0.40.3-0.40.2-0.30.5-0.6-0.5
Times rat made contact with spout0.40.42.01.00.4-0.40.1-0.4-1.4-0.0-0.2
Lifetime Intake0.70.91.5-0.4-1.11.1-0.71.0-0.71.20.9
Liver weight, left3.76.49.2-1.8-2.72.6-3.02.70.82.82.9
Liver weight, right2.84.97.2-1.4-2.42.4-2.42.50.22.72.5
Locomotor activity1.42.23.31.71.7-1.81.6-1.6-0.4-1.6-1.0
Locomotor testing distance1.12.74.12.01.8-1.81.7-1.7-1.1-1.5-1.3
Locomotor testing rearing0.10.31.60.90.3-0.30.2-0.4-1.30.0-0.1
Locomotion in novel chamber4.15.67.52.32.7-2.42.1-2.7-1.9-2.2-2.4
Locomotion in novel chamber post-restriction0.41.32.01.01.4-1.41.1-1.3-0.1-1.4-1.0
Fecal boli incidents, locomotor time 11.12.85.3-0.3-1.91.8-1.51.9-0.32.12.3
Change in fecal boli incidents, locomotor task0.50.50.90.40.7-0.90.6-0.90.0-0.9-0.7
Time >=10cm from walls, locomotor time 10.10.10.20.1-0.30.00.20.3-0.20.10.4
Bouts of movement, locomotor time 10.50.61.0-0.6-0.81.0-0.90.90.40.90.6
Total resting periods, locomotor time 10.60.71.2-1.0-0.81.1-0.80.90.60.90.5
Rest time, locomotor task time 10.91.41.61.31.2-1.21.2-1.2-1.1-1.1-1.2
Distance moved, locomotor task time 10.10.10.4-0.50.2-0.10.1-0.20.6-0.4-0.5
Vertical activity count, locomotor time 10.00.20.50.10.5-0.50.5-0.50.1-0.6-0.7
Time >=10cm from walls, locomotor time 20.41.01.5-0.9-1.21.1-0.91.10.31.21.1
Bouts of movement, locomotor time 20.20.50.9-0.7-0.70.7-1.00.70.70.60.7
Total resting periods, locomotor time 20.10.20.7-0.6-0.20.3-0.60.20.80.20.2
Rest time, locomotor task time 21.93.34.01.92.0-1.91.6-2.0-1.5-1.7-1.7
Distance moved, locomotor task time 20.10.10.2-0.4-0.30.4-0.40.30.10.30.1
Vertical activity count, locomotor time 20.00.10.20.30.2-0.20.2-0.2-0.5-0.2-0.2
Light reinforcement 10.10.51.71.3-0.0-0.1-0.20.1-1.30.40.7
Light reinforcement 20.00.00.10.10.10.0-0.2-0.00.20.00.0
Bone: marrow area0.51.21.5-1.1-1.21.2-1.11.20.51.21.1
Bone: maximum diameter1.12.24.6-2.1-1.41.5-1.41.31.91.00.9
Bone: maximum force0.81.52.0-1.4-1.31.4-1.31.30.81.21.1
Bone: maximum moment0.40.70.8-0.9-0.90.9-0.80.90.40.80.8
Mean time between licks in bursts0.31.62.0-1.0-1.41.4-1.21.40.91.31.3
Mean num. licks in bursts0.51.42.4-0.2-1.21.2-1.31.3-0.91.61.3
Cd content in liver0.00.00.10.1-0.00.10.00.2-0.20.20.3
Co content in liver0.81.02.11.51.0-0.91.0-0.9-1.2-0.7-0.6
Cu content in liver0.91.01.60.11.1-0.91.2-0.90.9-1.2-1.3
Fe content in liver0.40.41.3-0.50.7-0.30.6-0.50.4-0.7-1.1
K content in liver0.50.50.70.40.7-0.80.9-0.7-0.6-0.7-0.7
Mg content in liver0.40.41.4-1.2-0.60.5-0.40.50.70.40.5
Mn content in liver0.10.20.5-0.7-0.40.3-0.20.3-0.40.40.2
Na content in liver1.01.22.00.01.1-1.01.1-1.10.7-1.4-1.4
Rb content in liver0.10.10.2-0.50.3-0.20.4-0.30.3-0.3-0.5
Se content in liver1.41.63.6-1.9-1.21.3-1.21.21.21.00.7
Sr content in liver0.50.50.7-0.1-0.90.7-0.80.7-0.10.80.8
Zn content in liver1.11.32.5-0.5-1.21.1-0.91.30.51.31.6
Bone: minimum diameter2.14.05.4-2.3-2.22.2-1.92.11.42.01.8
Time in familiar zone, hab. session 10.40.40.90.90.7-0.70.7-0.6-0.5-0.6-0.5
Time in novel zone, hab. session 11.21.33.7-1.9-0.90.9-1.00.81.80.50.4
Total zone transitions, hab. session 10.40.51.30.10.8-0.60.8-0.8-0.2-0.8-1.1
Total locomotion distance, hab. session 10.60.81.71.10.8-0.90.8-0.9-1.3-0.7-0.7
Locomotion velocity, hab. session 10.91.33.01.51.0-1.11.0-1.0-1.7-0.7-0.7
Time in familiar zone, hab. session 20.40.40.80.80.6-0.60.9-0.6-0.3-0.6-0.5
Time in novel zone, hab. session 20.10.10.1-0.1-0.20.2-0.30.2-0.20.30.3
Total zone transitions, hab. session 23.44.46.51.32.3-2.12.5-2.3-0.7-2.3-2.6
Total locomotion distance, hab. session 23.44.46.32.52.1-2.12.2-2.1-2.2-1.8-1.8
Locomotion velocity, hab. session 22.53.35.02.21.7-1.81.9-1.7-2.1-1.4-1.5
Novel to familiar place preference ratio0.20.20.4-0.2-0.50.5-0.50.5-0.50.60.5
Novelty place preference0.10.10.2-0.2-0.40.4-0.40.4-0.30.50.3
Time in novel zone, NPP test0.20.20.3-0.3-0.50.5-0.50.5-0.20.60.5
Total zone transitions, NPP test2.63.85.31.22.2-2.12.2-2.2-0.2-2.3-2.3
Total locomotion distance, NPP test3.44.87.02.62.1-2.22.3-2.1-2.4-1.8-1.7
Locomotion velocity, NPP test3.55.17.22.72.2-2.32.3-2.2-2.4-1.9-1.8
Intraocular pressure0.10.21.30.3-0.20.20.00.0-1.10.40.1
Delta distance traveled before/after self-admin0.40.40.7-0.4-0.60.6-0.80.60.30.70.8
Delta ambulatory time before/after self-admin0.50.91.6-0.5-0.90.9-1.20.90.31.11.2
Parametrial fat weight1.12.64.31.0-1.41.3-1.41.4-2.02.02.1
Pavlov. Cond. lever latency0.60.71.10.30.9-0.81.1-0.9-0.5-0.9-1.0
Pavlov. Cond. magazine entry latency2.12.73.3-1.4-1.81.8-1.71.81.01.71.7
Pavlov. Cond. change in total contacts0.20.20.3-0.2-0.50.5-0.60.50.40.50.5
Pavlov. Cond. index score2.32.93.5-1.6-1.81.8-1.91.81.51.61.6
Pavlov. Cond. latency score1.62.02.4-1.3-1.41.4-1.61.41.41.31.4
Pavlov. Cond. lever contacts0.81.01.6-0.4-1.01.1-1.31.00.41.11.1
Pavlov. Cond. magazine entry number1.21.51.91.41.3-1.41.3-1.3-1.0-1.2-1.1
Pavlov. Cond. intertrial magazine entries2.63.16.02.51.8-1.71.6-1.7-2.0-1.4-1.3
Pavlov. Cond. lever-magazine prob. diff.2.83.54.2-1.8-1.92.0-2.01.91.61.81.8
Pavlov. Cond. response bias1.11.41.9-0.7-1.31.3-1.31.30.31.41.3
Pavlov. Cond. lever latency2.63.75.2-2.3-1.91.9-1.81.92.11.61.7
Pavlov. Cond. magazine entry latency0.10.10.30.3-0.20.1-0.20.2-0.60.40.4
Pavlov. Cond. change in total contacts0.30.72.01.10.7-0.60.7-0.7-1.4-0.5-0.7
Pavlov. Cond. index score0.40.61.71.10.7-0.60.5-0.6-1.3-0.4-0.5
Pavlov. Cond. latency score0.30.51.31.00.7-0.60.5-0.6-1.2-0.4-0.6
Pavlov. Cond. lever contacts2.33.44.82.21.9-1.81.7-1.8-2.1-1.6-1.7
Pavlov. Cond. magazine entry number0.00.10.2-0.4-0.00.1-0.00.00.5-0.1-0.2
Pavlov. Cond. intertrial magazine entries0.40.91.3-0.5-1.11.1-1.01.1-0.11.11.1
Pavlov. Cond. lever-magazine prob. diff.0.30.51.61.00.6-0.60.5-0.6-1.3-0.3-0.5
Pavlov. Cond. response bias1.82.54.32.11.5-1.51.4-1.4-2.1-1.2-1.2
Time in closed arm before self-admin0.10.20.90.7-0.20.20.20.3-0.90.30.1
Time in closed arm after self-admin0.91.03.6-1.6-0.60.9-0.50.71.90.30.2
Time in open arm before self-admin0.20.20.5-0.10.4-0.5-0.1-0.50.7-0.5-0.1
Time in open arm after self-admin1.41.54.72.20.8-1.20.7-1.0-2.0-0.5-0.1
Bone: periosteal estimation1.43.35.1-2.2-1.91.9-1.81.81.61.61.5
Bone: periosteal perimeter0.81.72.7-1.7-1.31.3-1.31.31.21.11.1
Bone: post-yield work0.91.62.0-1.1-1.41.4-1.41.30.31.41.3
Progressive ratio test 1 active lever presses0.00.10.3-0.1-0.20.20.20.1-0.50.1-0.3
Progressive ratio test 1 breakpoint0.00.10.4-0.1-0.20.20.20.1-0.60.2-0.2
Progressive ratio test 1 inactive lever presses0.00.10.3-0.6-0.30.3-0.3-0.0-0.10.3-0.0
Progressive ratio test 2 active lever presses0.30.50.9-0.7-0.90.9-0.40.7-0.40.80.3
Progressive ratio test 2 breakpoint0.40.50.9-0.8-0.90.9-0.40.7-0.30.80.3
Progressive ratio test 2 inactive lever presses0.10.20.4-0.4-0.60.6-0.40.3-0.40.60.3
Incentive Sensitization - Responses0.20.51.3-1.1-0.80.8-0.50.60.50.60.3
Incentive Sensitization - Breakpoint0.30.61.5-1.2-0.80.9-0.50.70.70.60.3
Sum of active levers in priming session hrs 5-60.10.10.3-0.4-0.10.2-0.60.10.40.20.2
Progressive ratio0.00.10.3-0.40.1-0.10.1-0.30.6-0.3-0.4
Food seeking constrained by brief footshock3.54.45.42.32.1-2.02.2-2.2-2.2-1.8-2.0
Seeking ratio, punishment vs. effort0.51.22.01.41.0-0.91.2-0.8-1.4-0.8-0.9
Retroperitoneal fat weight0.10.31.41.0-0.00.10.10.1-1.20.40.2
Reaction time number correct0.10.30.90.9-0.30.0-0.10.3-0.70.40.9
Reaction time mean minus median0.53.03.6-1.7-1.91.8-1.81.81.11.81.8
Reaction time mean minus median AUC0.00.30.4-0.4-0.60.5-0.60.60.20.60.6
Reaction time num false alarms0.10.20.30.2-0.50.4-0.40.5-0.50.60.4
Reaction time num false alarms AUC0.10.10.50.70.1-0.20.2-0.1-0.7-0.0-0.1
Reaction time trials correct on left0.10.30.90.9-0.30.0-0.10.3-0.70.40.9
Reaction time trials on left0.10.40.90.9-0.40.1-0.20.3-0.70.51.0
Reaction time mean1.22.73.4-1.8-1.61.5-1.71.61.71.41.6
Reaction time mean AUC1.12.73.5-1.9-1.71.6-1.71.61.71.51.7
Median of all reaction times1.22.02.5-1.6-1.41.3-1.41.31.61.21.4
Reaction time omissions0.40.71.1-0.9-0.80.8-1.00.80.50.80.9
Reaction time false alarm rate0.00.00.20.10.2-0.10.1-0.1-0.2-0.1-0.4
Reaction time premature initiation rate1.62.43.5-0.9-1.61.7-1.91.70.21.91.9
Reaction time premature initiations0.82.54.4-0.6-1.61.6-1.81.70.11.92.1
Std. dev. reaction times1.13.74.4-2.0-2.01.9-2.11.91.41.92.0
Reaction time trials completed0.10.40.90.9-0.40.1-0.20.3-0.70.51.0
Reaction time trials AUC0.10.41.10.9-0.40.1-0.20.4-0.70.61.0
Run reversals in cocaine runway, females1.11.22.0-0.71.0-0.91.3-0.91.1-1.4-1.3
Run reversals in cocaine runway, males1.71.82.61.51.4-1.41.2-1.3-1.6-1.1-1.2
Latency to leave start box in cocaine runway0.00.00.1-0.2-0.00.1-0.20.20.40.10.2
Latency to leave start box in cocaine runway, F0.00.00.10.0-0.20.20.00.3-0.30.20.1
Latency to leave start box in cocaine runway, M0.40.42.5-0.60.3-0.2-0.3-0.11.6-0.4-0.1
Std. dev. time between licks in bursts0.20.30.50.50.6-0.60.7-0.50.3-0.7-0.3
Total sessions with >9 infusions0.10.10.3-0.0-0.30.30.10.2-0.60.20.0
Short access day 1 total inactive lever presses0.10.20.30.10.6-0.20.3-0.4-0.5-0.3-0.5
Short access day 10 total inactive lever presses0.00.10.4-0.30.1-0.0-0.2-0.00.6-0.00.1
Short access day 1 total infusions0.10.10.4-0.3-0.20.20.40.2-0.60.1-0.2
Short access day 10 total infusions0.30.61.0-0.1-0.90.8-0.60.8-0.61.00.9
Short access total infusions0.20.20.4-0.1-0.50.6-0.30.5-0.60.60.3
Short access day 1 locomotion0.00.10.2-0.5-0.30.3-0.10.3-0.20.20.1
Short access day 10 total locomotion0.10.40.7-0.10.6-0.60.8-0.50.2-0.8-0.8
Short access total locomotion0.00.00.20.20.0-0.10.2-0.1-0.4-0.0-0.1
One hour access (0.3 mA shock)0.30.30.6-0.5-0.80.6-0.50.6-0.10.70.7
Compulsive drug intake0.81.21.71.21.3-1.20.9-1.2-0.6-1.1-1.1
One hour access (shock baseline)0.30.81.4-0.5-1.11.0-0.71.0-0.41.21.1
Social response proportion0.40.51.5-0.90.5-0.20.5-0.40.7-0.6-1.2
Social responses0.30.40.90.00.8-0.60.5-0.7-0.1-0.7-1.0
Social time0.40.61.21.10.8-0.90.4-0.8-0.9-0.6-0.3
Soleus weight0.82.25.72.41.2-1.21.1-1.2-2.3-0.7-0.7
Bone: stiffness1.93.54.3-1.8-2.02.1-2.12.10.82.01.8
Tibialis anterior weight0.10.31.30.9-0.00.1-0.30.1-1.10.40.3
Time to tail flick, vehicle, before self-admin1.01.22.00.51.2-1.11.4-1.10.1-1.3-1.2
Time to tail flick, vehicle, after self-admin0.10.20.30.30.5-0.50.6-0.6-0.0-0.5-0.4
Time to tail flick, test, before self-admin1.31.52.6-0.31.1-1.11.4-1.11.3-1.6-1.4
Time to tail flick, test, after self-admin2.93.14.31.31.8-2.02.1-1.8-0.6-2.1-1.7
Delta time to tail flick, vehicle, before/after SA0.70.71.4-0.1-0.90.8-1.10.8-0.41.01.2
Delta time to tail flick, test, before/after SA0.20.31.20.80.2-0.40.2-0.3-1.1-0.1-0.0
Tibia length1.02.85.0-2.2-1.61.9-1.71.61.61.51.0
Ambulatory time before self-admin1.23.64.81.61.8-1.72.1-1.8-2.0-1.7-2.2
Ambulatory time after self-admin0.50.84.01.40.4-0.40.4-0.4-2.0-0.0-0.2
Bone: tissue strength0.00.00.10.1-0.10.0-0.20.1-0.10.20.3
Total heroin consumption0.20.30.50.10.7-0.50.4-0.70.2-0.6-0.7
Bone: trabecular number0.10.20.40.20.5-0.50.6-0.5-0.0-0.6-0.6
Bone: trabecular spacing0.20.30.7-0.4-0.60.5-0.60.50.80.40.7
Bone: trabecular thickness0.20.20.60.70.4-0.40.3-0.4-0.8-0.2-0.2
Bone: trabecular tissue density0.40.81.3-1.0-0.90.9-0.61.01.10.70.7
Water consumed over 24 hours0.51.04.91.80.2-0.40.2-0.2-2.20.20.3
Number of responses in last shaping day0.30.40.9-0.5-0.70.5-0.90.50.50.60.8