Hub : Genes

Csnk1g2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Csnk1g2 0.05 0.04 7.9e-03 0.03 0.03 0.01 0.03 6.8e-03 8.7e-03 1.0e-01 1.3e-02
2 Adipose mRNA stability Csnk1g2 0.03 0.02 2.4e-03 0.01 0.02 0.01 0.01 1.1e-02 5.0e-03 8.7e-03 1.1e-02
3 Brain gene expression Csnk1g2 0.03 0.02 4.4e-03 0.02 0.01 0.02 0.01 1.2e-02 1.3e-02 1.1e-02 1.9e-02
4 PL gene expression Csnk1g2 0.02 0.02 8.0e-03 0.02 0.02 0.02 0.02 3.8e-03 2.7e-03 2.5e-03 6.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.61.13.21.00.00.3-1.8
Area under the delay curve2.32.52.7-1.51.7-1.6-1.5
BMI with tail5.818.723.2-4.84.8-4.5-2.8
BMI without tail2.55.17.6-2.82.4-2.6-0.5
Body weight1.14.65.7-2.32.3-2.4-1.3
Weight adjusted by age0.60.71.0-1.00.7-0.90.6
Bone surface1.42.54.62.0-0.61.0-2.1
Bone volume1.42.44.62.0-0.60.9-2.1
Breakpoint value in progressive ratio session5.15.66.51.9-2.52.42.5
Number of licking bursts0.30.40.9-0.80.2-0.10.9
Context. condit. distance diff. score0.30.40.6-0.70.6-0.8-0.2
Locomotion velocity, session 10.80.91.91.4-0.80.8-0.6
Locomotion distance, session 10.91.12.01.2-0.51.0-1.4
Locomotion velocity, session 24.04.77.92.8-2.22.4-0.2
Locomotion distance, session 22.33.35.22.3-1.62.1-0.8
Locomotion velocity, session 35.26.17.52.5-2.72.52.1
Locomotion distance, session 30.00.00.1-0.10.1-0.40.2
Stereotopy head waving bouts, day 34.65.47.92.4-2.62.81.3
Stereotopy head waving duration, day 35.36.48.62.6-2.82.91.6
Locomotion velocity, session 70.50.51.31.1-0.8-0.00.5
Locomotion distance, session 70.30.41.1-0.50.4-1.10.4
Stereotopy head waving bouts, day 70.30.30.80.5-0.10.3-0.9
Stereotopy head waving duration, day 70.50.60.91.0-0.50.7-0.7
Locomotion velocity, session 81.01.22.11.5-0.81.1-1.0
Locomotion distance, session 80.20.30.50.6-0.40.7-0.4
Degree of sensitization distance0.40.40.5-0.50.7-0.7-0.5
Degree of sensitization stereotypy1.81.93.1-0.91.4-1.4-1.8
Conditioned locomotion1.61.93.5-1.91.4-1.40.1
Cocaine response after cond. corrected5.76.49.2-3.02.6-3.0-0.6
Cocaine response after cond. not corrected6.06.69.7-3.02.7-3.1-0.5
Cocaine response before conditioning0.40.51.11.1-0.80.60.3
Saline control response0.10.10.2-0.50.2-0.10.1
Bone: connectivity density0.50.93.00.40.5-0.2-1.7
Bone: cortical apparent density0.70.91.1-1.01.0-0.9-0.7
Bone: cortical area0.71.02.3-0.20.9-1.0-1.5
Bone: cortical porosity0.60.71.21.1-0.80.9-0.0
Bone: cortical porosity0.40.40.80.8-0.20.4-0.9
Bone: cortical thickness1.01.62.2-0.91.4-1.3-1.5
Bone: cortical thickness0.20.20.6-0.40.1-0.50.8
Bone: cortical tissue density0.40.60.8-0.90.8-0.7-0.5
Condit. Reinf. active minus inactive responses3.64.15.12.1-2.32.21.5
Condit. Reinf. active-inactive response ratio1.71.92.41.2-1.51.21.6
Condit. Reinf. active responses3.64.46.52.4-2.32.50.8
Condit. Reinf. inactive responses1.31.62.81.4-1.11.7-0.4
Incentive salience index mean2.12.53.51.8-1.71.90.5
Condit. Reinf. lever presses0.60.82.00.8-0.20.8-1.4
Condit. Reinf. active minus inactive responses2.02.53.91.1-1.71.42.0
Condit. Reinf. active-inactive response ratio0.50.51.7-0.5-0.20.41.3
Condit. Reinf. active responses1.62.32.91.5-1.71.21.5
Condit. Reinf. inactive responses0.81.02.11.5-1.10.40.5
Condit. Reinf. lever presses2.02.73.81.4-1.81.52.0
Condit. Reinf. lever reinforcers received1.21.72.61.2-1.40.91.6
Conditioned reinforcement - actives2.12.12.51.6-1.61.31.3
Conditioned reinforcement - inactives0.60.71.3-0.90.8-1.1-0.1
Conditioned locomotion6.67.99.62.9-3.12.82.4
Patch foraging indifference point 0 sec0.10.20.3-0.30.4-0.2-0.5
Patch foraging indifference point AUC0.91.01.20.9-1.01.11.0
Delay disc. indifference point, 0s delay6.47.011.9-1.92.7-2.2-3.5
Delay disc. indifference point, 16s delay0.10.10.2-0.40.4-0.4-0.4
Delay disc. indifference point, 2s delay5.15.76.6-2.12.6-2.4-2.5
Delay disc. indifference point, 24s delay0.70.70.9-0.90.9-0.9-0.4
Delay disc. indifference point, 4s delay1.21.31.9-0.91.1-1.0-1.4
Delay disc. indifference point, 8s delay1.31.31.8-1.31.3-1.3-0.6
Indifference point function ln k0.30.40.9-0.60.6-0.9-0.3
Indifference point function log k0.30.40.9-0.60.6-0.9-0.3
Patch foraging total patch changes 0 sec0.10.10.1-0.40.4-0.2-0.3
Patch foraging total patch changes 12 sec0.30.41.1-1.00.6-0.40.3
Patch foraging total patch changes 18 sec1.11.52.11.1-1.21.41.0
Patch foraging total patch changes 24 sec0.10.10.40.2-0.30.60.2
Patch foraging total patch changes 6 sec0.30.40.80.6-0.60.90.3
Patch foraging time to switch 0 sec1.32.05.6-0.71.3-0.7-2.4
Patch foraging water rate 0 sec0.50.82.4-0.70.1-0.71.5
Patch foraging water rate 12 sec1.52.23.9-2.01.4-1.70.6
Patch foraging water rate 18 sec1.52.06.3-1.2-0.1-0.42.5
Patch foraging water rate 24 sec1.52.13.1-1.80.8-1.31.7
Patch foraging water rate 6 sec0.71.03.9-0.1-0.50.02.0
Seeking ratio, delayed vs. immediate footshock4.14.75.82.4-2.42.41.3
Distance traveled before self-admin0.40.40.8-0.40.6-0.7-0.9
Distance traveled after self-admin0.50.60.90.9-0.90.70.4
Extensor digitorum longus weight4.417.522.6-4.84.5-4.7-2.2
Bone: elastic displacement0.30.30.50.7-0.60.60.3
Bone: elastic work0.30.30.6-0.10.5-0.7-0.7
Bone: endosteal estimation0.20.40.7-0.40.6-0.7-0.9
Bone: endosteal perimeter0.20.51.21.1-0.70.5-0.2
Epididymis fat weight0.30.71.10.2-0.71.01.1
Delta time in closed arm before/after self-admin1.61.62.9-1.70.9-1.11.1
Delta time in open arm before/after self-admin1.11.11.8-0.71.1-0.9-1.3
Diff in mean of infusions in LGA sessions1.71.92.51.2-1.51.61.1
Delay discount exponential model param2.12.32.51.5-1.61.61.4
Extinction: sum of active levers before priming1.51.53.50.5-1.11.11.9
Active lever presses in extinction session 62.52.43.21.6-1.81.61.2
Bone: final force1.32.13.2-0.81.5-1.6-1.8
Bone: final moment1.01.72.6-0.61.3-1.4-1.6
Food consumed during 24 hour testing period0.60.71.0-1.00.9-0.9-0.3
Glucose1.31.92.4-1.61.5-1.5-0.8
Heart weight0.30.51.20.2-0.60.51.1
Delay discount hyperbolic model param2.93.13.51.7-1.91.81.6
Intermittent access intake day 1-15 change5.85.87.22.2-2.72.42.3
Intermittent access intake escalation5.85.78.31.8-2.52.22.9
Intermittent access intake escalation 27.37.29.82.1-2.82.63.1
Intermitt. access day 1 inactive lever presses0.30.31.1-0.0-0.4-0.11.1
Intermitt. access day 15 inactive lever presses0.40.50.70.6-0.70.60.8
Intermitt. access escalation Index0.50.41.40.20.4-0.2-1.2
Intermittent access day 1 total infusions0.10.10.1-0.20.2-0.4-0.2
Intermittent access day 15 total infusions1.71.92.81.1-1.51.11.7
Intermittent access terminal intake (last 3 days)0.91.01.31.0-1.10.81.1
Intermittent access total infusions0.20.20.40.3-0.50.20.7
Intermittent access day 1 locomotion0.30.30.40.5-0.60.50.6
Intermittent access day 15 total locomotion3.23.54.21.7-2.11.91.7
Intermittent access total locomotion0.91.01.31.0-1.10.90.8
Intermittent access standard deviation2.42.63.51.4-1.81.31.9
Left kidney weight0.10.30.70.8-0.30.3-0.4
Right kidney weight1.33.65.32.3-2.01.91.2
Cocaine induced anxiety0.91.02.11.4-0.91.1-0.2
Post-drug Anxiety0.80.91.81.3-0.70.9-0.6
Baseline Anxiety0.10.10.5-0.1-0.20.20.7
Tail length2.67.99.62.7-3.12.72.7
Length with tail1.66.08.52.9-2.72.41.5
Length without tail0.20.50.91.0-0.40.4-0.9
Times rat made contact with spout0.30.40.8-0.90.5-0.60.3
Lifetime Intake0.10.10.20.2-0.30.00.4
Liver weight, left2.13.45.4-2.32.1-1.7-1.0
Liver weight, right1.42.33.0-1.51.7-1.4-1.4
Locomotor activity3.45.38.02.8-2.42.60.8
Locomotor testing distance2.03.34.52.1-1.92.10.9
Locomotor testing rearing0.10.20.7-0.1-0.10.10.8
Locomotion in novel chamber0.50.61.20.1-0.60.91.1
Locomotion in novel chamber post-restriction0.70.81.20.7-0.90.91.1
Fecal boli incidents, locomotor time 11.11.22.0-1.21.4-1.0-0.6
Change in fecal boli incidents, locomotor task0.20.20.40.6-0.4-0.3-0.2
Time >=10cm from walls, locomotor time 10.50.51.4-0.00.6-0.5-1.2
Bouts of movement, locomotor time 10.10.10.10.3-0.4-0.00.4
Total resting periods, locomotor time 10.10.10.30.4-0.50.10.3
Rest time, locomotor task time 10.20.20.50.7-0.50.50.1
Distance moved, locomotor task time 10.60.61.5-0.40.7-0.6-1.2
Vertical activity count, locomotor time 10.30.30.6-0.60.4-0.80.2
Time >=10cm from walls, locomotor time 21.31.32.0-1.31.2-1.4-0.5
Bouts of movement, locomotor time 20.80.91.61.3-0.81.0-0.5
Total resting periods, locomotor time 20.80.81.41.2-0.71.0-0.5
Rest time, locomotor task time 20.60.71.21.1-0.81.0-0.0
Distance moved, locomotor task time 20.70.81.6-1.31.0-0.9-0.1
Vertical activity count, locomotor time 20.91.01.8-1.31.0-1.10.3
Light reinforcement 15.710.514.13.5-3.53.81.8
Light reinforcement 22.02.74.02.0-1.81.80.7
Bone: marrow area0.20.50.7-0.40.7-0.7-0.8
Bone: maximum diameter0.71.42.91.7-1.21.1-0.2
Bone: maximum force1.32.23.2-0.91.5-1.8-1.6
Bone: maximum moment1.11.82.6-0.71.4-1.6-1.5
Mean time between licks in bursts3.95.56.42.1-2.52.52.3
Mean num. licks in bursts0.10.10.30.10.2-0.4-0.5
Cd content in liver0.20.20.3-0.30.5-0.5-0.6
Co content in liver0.50.60.70.7-0.80.80.8
Cu content in liver0.40.41.50.30.3-0.3-1.2
Fe content in liver0.10.10.2-0.1-0.10.00.5
K content in liver0.40.40.90.6-0.00.3-1.0
Mg content in liver0.40.41.10.6-0.00.3-1.1
Mn content in liver1.61.83.82.0-1.11.1-1.1
Na content in liver0.91.02.7-0.30.9-0.6-1.6
Rb content in liver0.60.72.30.20.6-0.5-1.5
Se content in liver0.20.20.40.6-0.50.50.1
Sr content in liver0.20.20.7-0.40.0-0.10.8
Zn content in liver2.12.35.90.5-1.31.22.4
Bone: minimum diameter0.10.10.40.30.1-0.2-0.6
Time in familiar zone, hab. session 11.91.82.41.1-1.41.21.5
Time in novel zone, hab. session 11.21.22.7-0.30.9-1.1-1.6
Total zone transitions, hab. session 11.31.83.11.8-1.21.5-0.5
Total locomotion distance, hab. session 11.72.44.62.2-1.31.5-1.1
Locomotion velocity, hab. session 12.02.94.92.2-1.62.0-0.6
Time in familiar zone, hab. session 25.55.77.31.9-2.62.32.7
Time in novel zone, hab. session 24.34.35.9-1.52.2-2.1-2.4
Total zone transitions, hab. session 21.01.24.40.60.20.5-2.1
Total locomotion distance, hab. session 21.51.93.01.7-1.21.7-0.6
Locomotion velocity, hab. session 21.72.23.31.8-1.21.8-0.9
Novel to familiar place preference ratio4.04.16.6-1.42.0-1.9-2.6
Novelty place preference2.52.64.7-1.01.6-1.5-2.2
Time in novel zone, NPP test2.93.04.8-1.11.7-1.7-2.2
Total zone transitions, NPP test0.40.61.40.5-0.20.8-1.2
Total locomotion distance, NPP test0.50.62.00.6-0.00.4-1.4
Locomotion velocity, NPP test0.50.71.40.9-0.30.8-1.2
Intraocular pressure0.50.72.0-0.80.0-0.21.4
Delta distance traveled before/after self-admin1.51.72.11.4-1.41.30.9
Delta ambulatory time before/after self-admin1.61.72.31.5-1.51.40.8
Parametrial fat weight0.30.61.10.7-0.90.51.0
Pavlov. Cond. lever latency0.20.31.0-0.4-0.0-0.31.0
Pavlov. Cond. magazine entry latency2.73.54.61.6-2.02.11.7
Pavlov. Cond. change in total contacts0.10.10.30.2-0.30.50.1
Pavlov. Cond. index score0.50.61.00.9-0.81.0-0.1
Pavlov. Cond. latency score0.50.71.01.0-0.81.0-0.4
Pavlov. Cond. lever contacts0.40.41.00.7-0.20.5-1.0
Pavlov. Cond. magazine entry number0.70.91.4-0.81.0-1.2-0.7
Pavlov. Cond. intertrial magazine entries0.20.31.0-0.1-0.30.31.0
Pavlov. Cond. lever-magazine prob. diff.0.80.91.51.1-1.01.20.2
Pavlov. Cond. response bias1.01.31.81.1-1.21.40.8
Pavlov. Cond. lever latency0.60.81.6-1.31.0-0.4-0.7
Pavlov. Cond. magazine entry latency0.30.40.80.9-0.70.30.5
Pavlov. Cond. change in total contacts0.60.81.11.0-1.00.60.9
Pavlov. Cond. index score0.70.91.41.2-1.00.50.9
Pavlov. Cond. latency score0.70.81.61.3-1.00.50.7
Pavlov. Cond. lever contacts0.60.81.11.0-0.90.41.1
Pavlov. Cond. magazine entry number0.60.71.3-1.10.9-0.5-0.6
Pavlov. Cond. intertrial magazine entries0.40.51.0-1.00.7-0.80.1
Pavlov. Cond. lever-magazine prob. diff.0.70.91.61.3-1.00.60.8
Pavlov. Cond. response bias1.42.02.51.5-1.51.01.6
Time in closed arm before self-admin0.91.03.0-0.10.8-0.4-1.7
Time in closed arm after self-admin0.00.00.1-0.0-0.10.10.3
Time in open arm before self-admin0.70.81.50.6-1.00.71.2
Time in open arm after self-admin0.70.70.9-0.90.9-0.9-0.6
Bone: periosteal estimation0.40.92.2-0.10.8-0.8-1.5
Bone: periosteal perimeter0.20.40.80.9-0.30.1-0.7
Bone: post-yield work0.60.81.3-0.91.0-1.1-0.5
Progressive ratio test 1 active lever presses0.20.20.3-0.50.3-0.60.2
Progressive ratio test 1 breakpoint0.20.20.5-0.60.4-0.70.0
Progressive ratio test 1 inactive lever presses0.00.00.00.2-0.1-0.10.0
Progressive ratio test 2 active lever presses0.20.20.80.0-0.4-0.10.9
Progressive ratio test 2 breakpoint0.20.20.40.3-0.50.10.6
Progressive ratio test 2 inactive lever presses0.00.00.10.3-0.20.10.1
Incentive Sensitization - Responses0.30.31.0-0.1-0.40.01.0
Incentive Sensitization - Breakpoint0.30.30.90.0-0.40.10.9
Sum of active levers in priming session hrs 5-60.00.00.0-0.0-0.00.00.0
Progressive ratio0.20.30.9-0.90.5-0.2-0.1
Food seeking constrained by brief footshock0.20.30.90.3-0.51.00.1
Seeking ratio, punishment vs. effort0.30.30.80.9-0.50.6-0.1
Retroperitoneal fat weight0.30.91.4-1.21.0-0.9-0.5
Reaction time number correct1.01.42.2-1.51.0-1.40.6
Reaction time mean minus median0.50.70.90.9-0.90.50.9
Reaction time mean minus median AUC0.20.30.60.6-0.0-0.2-0.8
Reaction time num false alarms0.40.50.9-0.70.4-1.00.6
Reaction time num false alarms AUC0.50.71.0-0.90.5-1.00.8
Reaction time trials correct on left1.01.42.2-1.51.0-1.40.6
Reaction time trials on left0.91.32.1-1.41.0-1.40.5
Reaction time mean0.10.20.30.40.1-0.3-0.6
Reaction time mean AUC0.20.20.50.40.2-0.4-0.7
Median of all reaction times0.30.51.1-0.10.6-0.7-1.1
Reaction time omissions0.30.40.70.8-0.70.80.2
Reaction time false alarm rate0.00.00.1-0.10.2-0.40.1
Reaction time premature initiation rate1.11.42.40.8-1.21.21.5
Reaction time premature initiations0.81.23.80.0-0.80.52.0
Std. dev. reaction times0.20.20.70.8-0.50.10.2
Reaction time trials completed0.91.32.1-1.41.0-1.40.5
Reaction time trials AUC1.01.52.3-1.51.0-1.40.7
Run reversals in cocaine runway, females0.20.20.40.5-0.60.50.2
Run reversals in cocaine runway, males1.21.11.81.0-1.21.30.4
Latency to leave start box in cocaine runway1.11.22.11.4-1.11.3-0.0
Latency to leave start box in cocaine runway, F0.50.51.60.6-0.10.3-1.3
Latency to leave start box in cocaine runway, M3.02.95.01.2-1.61.62.2
Std. dev. time between licks in bursts0.60.81.71.3-1.00.60.2
Total sessions with >9 infusions0.10.10.10.20.0-0.4-0.3
Short access day 1 total inactive lever presses0.10.10.20.4-0.30.30.2
Short access day 10 total inactive lever presses0.10.10.3-0.0-0.10.10.5
Short access day 1 total infusions0.30.30.91.0-0.40.4-0.3
Short access day 10 total infusions0.10.10.2-0.0-0.1-0.30.4
Short access total infusions0.00.00.00.2-0.0-0.2-0.0
Short access day 1 locomotion0.91.02.11.5-1.10.70.3
Short access day 10 total locomotion3.64.04.82.0-2.21.72.1
Short access total locomotion0.80.81.41.2-1.00.60.7
One hour access (0.3 mA shock)0.20.30.6-0.50.5-0.7-0.2
Compulsive drug intake1.01.01.5-0.81.1-0.9-1.2
One hour access (shock baseline)0.10.10.5-0.0-0.2-0.30.7
Social response proportion0.91.01.61.3-0.91.2-0.1
Social responses6.48.212.43.5-3.12.91.5
Social time0.40.50.8-0.90.8-0.3-0.7
Soleus weight8.324.429.5-5.15.4-5.4-3.6
Bone: stiffness2.94.55.6-1.72.3-2.4-2.1
Tibialis anterior weight1.24.04.8-2.22.1-2.2-1.4
Time to tail flick, vehicle, before self-admin0.60.61.21.1-0.70.8-0.4
Time to tail flick, vehicle, after self-admin0.40.41.3-0.2-0.20.31.2
Time to tail flick, test, before self-admin0.40.40.80.9-0.50.5-0.5
Time to tail flick, test, after self-admin0.30.30.50.7-0.50.6-0.2
Delta time to tail flick, vehicle, before/after SA0.90.91.6-1.30.7-0.70.9
Delta time to tail flick, test, before/after SA0.20.20.60.0-0.30.20.7
Tibia length0.82.32.71.5-1.61.51.3
Ambulatory time before self-admin0.30.30.5-0.40.6-0.6-0.7
Ambulatory time after self-admin0.30.30.50.7-0.70.50.2
Bone: tissue strength1.41.31.7-1.01.3-1.1-1.2
Total heroin consumption1.72.02.61.2-1.61.61.2
Bone: trabecular number0.81.32.81.7-1.01.0-0.6
Bone: trabecular spacing1.41.83.4-1.80.8-1.01.4
Bone: trabecular thickness1.62.05.51.4-0.10.6-2.3
Bone: trabecular tissue density1.31.93.6-1.91.6-1.1-0.5
Water consumed over 24 hours0.70.81.7-0.40.8-0.9-1.3
Number of responses in last shaping day0.10.10.10.3-0.4-0.10.4