Hub : Genes

Csnk1g2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Csnk1g2	0.03	0.02	2.8e-03	0.01	0.02	0.01	0.01	1.3e-02	5.1e-03	1.1e-02	1.3e-02
2	NAcc	isoform ratio	XM_008765130.4	0.02	0.01	1.6e-03	0.01	0.01	0.01	0.01	1.2e-02	2.5e-03	6.9e-03	1.0e-02
3	Brain	gene expression	Csnk1g2	0.03	0.02	1.5e-03	0.02	0.02	0.02	0.02	8.0e-03	3.7e-03	6.3e-03	8.6e-03
4	NAcc	isoform ratio	XM_063264233.1	0.01	0.01	7.4e-03	0.02	0.01	0	0.01	1.4e-03	1.4e-02	5.0e-02	4.3e-03
5	NAcc	alternative TSS	XM_063264233.1	0.02	0.01	2.6e-03	0	0.01	0	0	1.5e-01	1.3e-02	6.5e-02	4.6e-02
6	IC	isoform ratio	XM_008765130.4	0.09	0.08	8.7e-03	0	0.02	0.01	0.01	3.4e-01	4.1e-02	7.3e-02	7.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.6	1.0	3.6	0.1	0.2	0.3	-0.9	-1.3	1.9
Area under the delay curve	1.5	2.2	2.7	1.6	1.6	1.6	1.4	-1.5	1.2
BMI with tail	5.9	20.5	26.4	4.9	4.9	4.9	5.1	-4.0	2.9
BMI without tail	1.0	5.3	7.6	2.6	2.6	2.6	2.8	-1.8	1.0
Body weight	0.9	3.7	4.9	2.1	2.1	2.1	2.2	-1.7	1.3
Weight adjusted by age	0.1	0.4	0.7	0.7	0.7	0.7	0.8	-0.1	-0.2
Bone surface	0.9	1.8	5.0	-0.6	-0.5	-0.4	-2.0	-1.2	2.2
Bone volume	0.9	1.8	5.1	-0.5	-0.4	-0.3	-2.0	-1.2	2.3
Breakpoint value in progressive ratio session	2.3	4.2	4.8	-2.2	-2.2	-2.2	-1.6	2.2	-1.9
Number of licking bursts	0.1	0.3	1.0	0.2	0.1	0.1	0.6	0.6	-1.0
Context. condit. distance diff. score	0.3	0.4	0.5	0.7	0.7	0.7	0.7	-0.5	0.3
Locomotion velocity, session 1	0.5	0.5	1.3	-0.8	-0.7	-0.7	-1.1	-0.0	0.5
Locomotion distance, session 1	0.6	0.7	2.3	-0.5	-0.4	-0.3	-0.9	-0.8	1.5
Locomotion velocity, session 2	2.9	3.5	6.5	-2.2	-2.1	-2.1	-2.6	0.8	0.2
Locomotion distance, session 2	1.5	2.1	4.4	-1.7	-1.6	-1.5	-2.1	0.2	0.8
Locomotion velocity, session 3	5.7	6.5	7.5	-2.7	-2.7	-2.7	-2.5	2.5	-2.1
Locomotion distance, session 3	0.0	0.0	0.1	0.0	0.0	0.0	0.1	0.2	-0.3
Stereotopy head waving bouts, day 3	4.1	4.9	6.4	-2.5	-2.5	-2.5	-2.5	1.8	-1.1
Stereotopy head waving duration, day 3	5.0	6.2	7.8	-2.8	-2.8	-2.8	-2.7	2.2	-1.5
Locomotion velocity, session 7	0.5	0.6	1.0	-0.7	-0.7	-0.7	-1.0	0.8	-0.7
Locomotion distance, session 7	0.2	0.3	0.4	0.5	0.5	0.4	0.7	0.2	-0.6
Stereotopy head waving bouts, day 7	0.3	0.3	1.1	0.0	0.0	0.1	-0.4	-0.7	1.1
Stereotopy head waving duration, day 7	0.4	0.5	1.2	-0.6	-0.6	-0.5	-1.1	-0.3	0.8
Locomotion velocity, session 8	0.7	0.8	2.0	-0.8	-0.8	-0.7	-1.4	-0.3	1.0
Locomotion distance, session 8	0.1	0.2	0.3	-0.5	-0.4	-0.4	-0.6	-0.1	0.4
Degree of sensitization distance	0.4	0.4	0.5	0.7	0.7	0.7	0.6	-0.6	0.5
Degree of sensitization stereotypy	1.8	2.0	2.8	1.3	1.4	1.4	0.9	-1.7	1.7
Conditioned locomotion	1.1	1.3	3.0	1.3	1.3	1.2	1.7	-0.4	-0.2
Cocaine response after cond. corrected	3.5	5.2	8.8	2.7	2.6	2.6	3.0	-1.4	0.4
Cocaine response after cond. not corrected	3.7	5.4	9.3	2.7	2.6	2.6	3.0	-1.4	0.3
Cocaine response before conditioning	0.4	0.5	1.0	-0.8	-0.8	-0.8	-1.0	0.5	-0.3
Saline control response	0.1	0.2	0.5	0.4	0.4	0.4	0.7	-0.0	-0.2
Bone: connectivity density	0.6	1.0	2.9	0.5	0.6	0.6	-0.2	-1.3	1.7
Bone: cortical apparent density	0.7	1.1	1.2	1.1	1.1	1.1	0.9	-1.1	0.9
Bone: cortical area	0.5	0.9	2.0	0.7	0.8	0.8	-0.0	-1.2	1.4
Bone: cortical porosity	0.2	0.2	0.6	-0.4	-0.4	-0.4	-0.8	-0.1	0.4
Bone: cortical porosity	0.3	0.3	1.2	-0.1	-0.1	-0.0	-0.7	-0.6	1.1
Bone: cortical thickness	1.1	1.8	2.5	1.3	1.3	1.3	0.7	-1.6	1.6
Bone: cortical thickness	0.2	0.3	1.1	-0.1	-0.1	-0.1	0.3	0.7	-1.0
Bone: cortical tissue density	0.4	0.7	0.8	0.9	0.9	0.9	0.7	-0.9	0.7
Condit. Reinf. active minus inactive responses	3.7	4.2	5.1	-2.3	-2.3	-2.3	-2.0	1.9	-1.5
Condit. Reinf. active-inactive response ratio	2.2	2.4	3.0	-1.5	-1.5	-1.6	-1.1	1.7	-1.7
Condit. Reinf. active responses	2.9	3.8	5.2	-2.3	-2.2	-2.2	-2.3	1.4	-0.7
Condit. Reinf. inactive responses	0.7	0.9	1.9	-1.1	-1.0	-1.0	-1.4	0.0	0.7
Incentive salience index mean	1.8	2.3	3.3	-1.8	-1.7	-1.7	-1.8	1.0	-0.5
Condit. Reinf. lever presses	0.4	0.6	2.2	-0.3	-0.2	-0.2	-0.7	-0.9	1.5
Condit. Reinf. active minus inactive responses	2.1	3.2	4.5	-1.7	-1.7	-1.8	-1.3	2.1	-2.1
Condit. Reinf. active-inactive response ratio	0.3	0.5	1.7	-0.2	-0.3	-0.3	0.5	1.0	-1.3
Condit. Reinf. active responses	2.2	3.2	3.7	-1.8	-1.8	-1.8	-1.7	1.9	-1.7
Condit. Reinf. inactive responses	1.0	1.4	2.3	-1.2	-1.2	-1.2	-1.5	1.1	-0.8
Condit. Reinf. lever presses	1.8	2.7	3.5	-1.6	-1.6	-1.6	-1.3	1.9	-1.8
Condit. Reinf. lever reinforcers received	1.8	2.6	3.5	-1.5	-1.5	-1.5	-1.3	1.9	-1.8
Conditioned reinforcement - actives	0.5	1.9	3.2	-1.2	-1.2	-1.2	-0.8	1.7	-1.8
Conditioned reinforcement - inactives	0.0	0.1	0.2	0.2	0.1	0.1	0.5	0.2	-0.5
Conditioned locomotion	6.2	9.2	10.7	-3.3	-3.3	-3.3	-3.0	3.0	-2.2
Patch foraging indifference point 0 sec	0.1	0.3	0.5	0.5	0.5	0.5	0.2	-0.7	0.7
Patch foraging indifference point AUC	0.5	1.2	1.5	-1.1	-1.1	-1.2	-0.8	1.2	-1.1
Delay disc. indifference point, 0s delay	8.2	9.2	12.7	2.8	2.9	3.0	2.1	-3.6	3.6
Delay disc. indifference point, 16s delay	0.1	0.2	0.2	0.4	0.4	0.4	0.3	-0.5	0.4
Delay disc. indifference point, 2s delay	6.1	6.8	8.0	2.7	2.7	2.7	2.1	-2.8	2.5
Delay disc. indifference point, 24s delay	0.3	0.5	0.8	0.8	0.8	0.8	0.9	-0.5	0.2
Delay disc. indifference point, 4s delay	1.4	1.5	2.0	1.2	1.2	1.3	0.7	-1.4	1.3
Delay disc. indifference point, 8s delay	0.7	1.2	1.6	1.3	1.2	1.2	1.3	-0.7	0.3
Indifference point function ln k	0.1	0.2	0.3	0.5	0.5	0.5	0.3	-0.2	0.0
Indifference point function log k	0.1	0.2	0.3	0.5	0.5	0.5	0.3	-0.2	0.0
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	0.4	0.4	0.5	0.2	-0.6	0.6
Patch foraging total patch changes 12 sec	0.3	0.5	1.3	0.7	0.7	0.7	1.1	-0.3	-0.0
Patch foraging total patch changes 18 sec	0.4	1.0	1.3	-1.1	-1.1	-1.1	-1.1	0.9	-0.6
Patch foraging total patch changes 24 sec	0.0	0.1	0.1	-0.3	-0.3	-0.3	-0.3	0.1	-0.0
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	-0.6	-0.6	-0.6	-0.6	0.3	0.0
Patch foraging time to switch 0 sec	0.7	2.8	6.1	1.3	1.4	1.4	0.7	-2.2	2.5
Patch foraging water rate 0 sec	0.2	0.7	2.8	0.1	-0.0	-0.0	0.6	1.1	-1.7
Patch foraging water rate 12 sec	0.4	1.5	3.4	1.3	1.2	1.2	1.8	-0.1	-0.7
Patch foraging water rate 18 sec	0.9	1.9	7.2	-0.1	-0.2	-0.3	1.0	1.8	-2.7
Patch foraging water rate 24 sec	1.0	1.5	3.5	0.8	0.7	0.6	1.8	0.9	-1.9
Patch foraging water rate 6 sec	0.9	1.3	4.4	-0.5	-0.6	-0.6	0.1	1.6	-2.1
Seeking ratio, delayed vs. immediate footshock	3.1	4.5	6.3	-2.3	-2.3	-2.3	-2.5	1.8	-1.2
Distance traveled before self-admin	0.1	0.2	0.4	0.3	0.4	0.4	0.2	-0.5	0.6
Distance traveled after self-admin	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.2	0.1	0.0
Extensor digitorum longus weight	3.7	14.8	20.8	4.3	4.3	4.3	4.6	-3.1	1.8
Bone: elastic displacement	0.1	0.2	0.3	-0.5	-0.5	-0.4	-0.5	0.4	-0.2
Bone: elastic work	0.3	0.4	0.5	0.6	0.6	0.7	0.1	-0.7	0.7
Bone: endosteal estimation	0.2	0.4	0.6	0.6	0.6	0.6	0.2	-0.8	0.8
Bone: endosteal perimeter	0.2	0.5	1.4	-0.7	-0.7	-0.7	-1.2	0.3	0.1
Epididymis fat weight	0.1	0.4	1.1	0.1	0.1	0.1	0.8	0.6	-1.1
Delta time in closed arm before/after self-admin	1.1	1.1	2.7	0.8	0.8	0.7	1.7	0.5	-1.3
Delta time in open arm before/after self-admin	0.5	0.6	0.6	0.8	0.8	0.8	0.8	-0.8	0.6
Diff in mean of infusions in LGA sessions	0.9	1.6	2.1	-1.4	-1.4	-1.4	-1.2	1.2	-0.9
Delay discount exponential model param	1.3	1.8	2.2	-1.5	-1.5	-1.5	-1.3	1.3	-1.0
Extinction: sum of active levers before priming	0.7	1.1	1.8	-1.0	-1.0	-1.1	-0.4	1.3	-1.3
Active lever presses in extinction session 6	2.1	2.2	2.7	-1.6	-1.6	-1.6	-1.6	1.3	-0.8
Bone: final force	1.3	2.2	3.2	1.4	1.5	1.5	0.6	-1.8	1.8
Bone: final moment	1.1	1.8	2.7	1.3	1.3	1.4	0.5	-1.6	1.6
Food consumed during 24 hour testing period	0.3	0.6	0.8	0.9	0.9	0.9	0.8	-0.6	0.3
Glucose	2.3	3.6	4.5	2.1	2.1	2.1	2.1	-1.6	1.2
Heart weight	0.8	1.2	3.0	-0.8	-0.9	-0.9	-0.3	1.5	-1.7
Delay discount hyperbolic model param	2.5	3.2	3.8	-1.9	-1.9	-2.0	-1.6	1.8	-1.5
Intermittent access intake day 1-15 change	1.3	6.9	8.6	-2.6	-2.6	-2.7	-2.1	2.9	-2.7
Intermittent access intake escalation	1.1	6.1	7.6	-2.4	-2.5	-2.5	-2.0	2.8	-2.5
Intermittent access intake escalation 2	3.1	5.3	6.2	-2.3	-2.3	-2.4	-2.0	2.5	-2.2
Intermitt. access day 1 inactive lever presses	0.1	0.8	2.6	-0.3	-0.3	-0.4	0.4	1.3	-1.6
Intermitt. access day 15 inactive lever presses	0.1	0.4	0.4	-0.7	-0.7	-0.7	-0.7	0.5	-0.4
Intermitt. access escalation Index	0.4	1.2	2.5	0.9	0.9	1.0	0.3	-1.4	1.6
Intermittent access day 1 total infusions	0.1	0.3	1.0	-0.3	-0.3	-0.3	0.0	0.8	-1.0
Intermittent access day 15 total infusions	1.6	3.8	4.9	-1.9	-1.9	-2.0	-1.6	2.2	-2.1
Intermittent access terminal intake (last 3 days)	1.4	2.5	3.2	-1.6	-1.6	-1.6	-1.3	1.8	-1.6
Intermittent access total infusions	1.1	1.3	1.8	-1.0	-1.1	-1.1	-0.8	1.3	-1.3
Intermittent access day 1 locomotion	1.2	2.1	3.8	-1.3	-1.3	-1.4	-0.6	1.8	-2.0
Intermittent access day 15 total locomotion	1.4	5.6	7.1	-2.4	-2.4	-2.4	-1.7	2.7	-2.5
Intermittent access total locomotion	2.5	3.0	4.1	-1.7	-1.7	-1.7	-1.2	2.0	-1.9
Intermittent access standard deviation	1.4	7.4	8.2	-2.9	-2.9	-2.9	-2.7	2.7	-2.2
Left kidney weight	0.0	0.2	0.8	0.2	0.1	0.1	0.6	0.5	-0.9
Right kidney weight	0.3	2.3	4.3	-1.3	-1.3	-1.4	-0.9	1.9	-2.1
Cocaine induced anxiety	0.5	1.3	2.8	-1.4	-1.3	-1.3	-1.7	0.4	0.3
Post-drug Anxiety	1.0	1.1	2.3	-1.2	-1.2	-1.1	-1.5	0.2	0.5
Baseline Anxiety	0.0	0.1	0.1	-0.2	-0.3	-0.2	-0.2	0.3	-0.4
Tail length	2.4	12.8	13.9	-3.7	-3.7	-3.7	-3.6	3.6	-3.0
Length with tail	1.8	7.8	8.7	-2.9	-3.0	-3.0	-2.7	2.8	-2.4
Length without tail	0.0	0.0	0.1	0.1	0.1	0.1	0.2	-0.0	-0.0
Times rat made contact with spout	0.2	0.2	0.5	0.5	0.5	0.4	0.7	0.1	-0.4
Lifetime Intake	0.6	0.7	1.2	-0.7	-0.8	-0.8	-0.5	1.1	-1.1
Liver weight, left	0.8	1.4	1.9	1.3	1.3	1.3	1.4	-1.0	0.6
Liver weight, right	0.5	0.9	1.5	1.1	1.1	1.1	1.2	-0.5	0.1
Locomotor activity	2.8	4.4	8.2	-2.4	-2.3	-2.3	-2.9	1.4	-0.5
Locomotor testing distance	1.1	2.8	5.1	-1.9	-1.8	-1.8	-2.3	1.1	-0.4
Locomotor testing rearing	0.0	0.1	0.5	-0.1	-0.2	-0.2	-0.0	0.5	-0.7
Locomotion in novel chamber	1.0	1.4	1.9	-1.2	-1.2	-1.2	-0.8	1.4	-1.2
Locomotion in novel chamber post-restriction	0.6	1.7	2.0	-1.3	-1.3	-1.3	-1.3	1.4	-1.3
Fecal boli incidents, locomotor time 1	0.7	1.8	2.8	1.4	1.4	1.4	1.7	-1.1	0.8
Change in fecal boli incidents, locomotor task	0.3	0.3	1.2	-0.5	-0.5	-0.4	-1.1	0.2	0.1
Time >=10cm from walls, locomotor time 1	0.5	0.6	1.6	0.5	0.5	0.6	0.0	-1.0	1.3
Bouts of movement, locomotor time 1	0.3	0.4	0.5	-0.6	-0.6	-0.6	-0.5	0.7	-0.7
Total resting periods, locomotor time 1	0.4	0.5	0.5	-0.7	-0.7	-0.7	-0.7	0.7	-0.6
Rest time, locomotor task time 1	0.1	0.2	0.4	-0.6	-0.5	-0.5	-0.6	0.3	-0.1
Distance moved, locomotor task time 1	0.4	1.0	2.3	0.8	0.8	0.9	0.2	-1.3	1.5
Vertical activity count, locomotor time 1	0.0	0.2	0.3	0.5	0.5	0.5	0.3	-0.1	-0.1
Time >=10cm from walls, locomotor time 2	0.4	1.1	1.5	1.2	1.2	1.2	1.2	-0.7	0.3
Bouts of movement, locomotor time 2	0.1	0.4	0.8	-0.7	-0.6	-0.6	-0.9	-0.0	0.5
Total resting periods, locomotor time 2	0.1	0.4	0.8	-0.6	-0.6	-0.5	-0.9	-0.1	0.6
Rest time, locomotor task time 2	0.4	0.6	1.2	-0.9	-0.9	-0.9	-1.1	0.4	-0.0
Distance moved, locomotor task time 2	0.5	0.6	1.1	0.9	0.9	0.9	1.0	-0.6	0.3
Vertical activity count, locomotor time 2	0.3	0.6	1.4	0.9	0.8	0.8	1.2	-0.1	-0.3
Light reinforcement 1	2.0	9.0	11.9	-3.4	-3.3	-3.3	-3.4	2.4	-1.5
Light reinforcement 2	1.1	2.4	3.6	-1.8	-1.7	-1.7	-1.9	1.2	-0.7
Bone: marrow area	0.2	0.4	0.6	0.6	0.6	0.6	0.3	-0.8	0.7
Bone: maximum diameter	0.7	1.4	3.3	-1.3	-1.3	-1.2	-1.8	0.6	0.0
Bone: maximum force	1.1	2.2	2.7	1.5	1.5	1.6	0.8	-1.7	1.6
Bone: maximum moment	1.0	1.8	2.3	1.4	1.4	1.4	0.7	-1.5	1.4
Mean time between licks in bursts	1.0	5.9	6.8	-2.6	-2.6	-2.6	-2.3	2.4	-2.0
Mean num. licks in bursts	0.0	0.1	0.2	0.2	0.2	0.2	-0.0	-0.4	0.5
Cd content in liver	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.5	0.3	-0.1
Co content in liver	1.6	1.9	2.2	-1.4	-1.4	-1.4	-1.2	1.5	-1.3
Cu content in liver	0.3	0.3	0.9	-0.5	-0.5	-0.5	-0.9	-0.1	0.6
Fe content in liver	0.2	0.2	0.4	-0.4	-0.4	-0.4	-0.1	0.6	-0.6
K content in liver	0.2	0.2	0.5	-0.2	-0.2	-0.1	-0.5	-0.4	0.7
Mg content in liver	0.2	0.3	0.5	-0.6	-0.6	-0.6	-0.7	0.2	0.0
Mn content in liver	1.5	1.7	4.7	-1.3	-1.3	-1.2	-2.2	0.2	0.6
Na content in liver	1.1	1.2	2.8	0.9	0.9	0.9	0.5	-1.4	1.7
Rb content in liver	0.3	0.3	1.1	-0.2	-0.1	-0.1	-0.7	-0.6	1.0
Se content in liver	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.4	0.5	-0.4
Sr content in liver	0.0	0.0	0.1	0.1	0.1	0.1	0.3	0.2	-0.3
Zn content in liver	4.4	5.1	8.4	-2.0	-2.1	-2.1	-1.1	2.8	-2.9
Bone: minimum diameter	0.1	0.1	0.4	0.1	0.1	0.2	-0.4	-0.4	0.6
Time in familiar zone, hab. session 1	1.9	2.1	2.6	-1.4	-1.4	-1.4	-1.2	1.6	-1.6
Time in novel zone, hab. session 1	1.1	1.2	2.3	1.0	1.0	1.0	0.4	-1.4	1.5
Total zone transitions, hab. session 1	0.8	1.1	2.4	-1.2	-1.1	-1.1	-1.5	0.1	0.7
Total locomotion distance, hab. session 1	1.2	1.6	4.0	-1.3	-1.2	-1.2	-2.0	-0.1	1.1
Locomotion velocity, hab. session 1	1.4	2.0	4.2	-1.6	-1.5	-1.5	-2.1	0.2	0.7
Time in familiar zone, hab. session 2	6.0	6.8	8.4	-2.6	-2.6	-2.7	-2.0	2.9	-2.7
Time in novel zone, hab. session 2	4.6	5.0	6.4	2.2	2.2	2.3	1.6	-2.5	2.4
Total zone transitions, hab. session 2	1.1	1.4	5.2	0.2	0.4	0.4	-0.3	-1.6	2.3
Total locomotion distance, hab. session 2	0.9	1.2	2.1	-1.3	-1.2	-1.2	-1.5	0.1	0.6
Locomotion velocity, hab. session 2	1.0	1.3	2.4	-1.3	-1.2	-1.2	-1.6	-0.1	1.0
Novel to familiar place preference ratio	3.6	4.8	6.7	2.1	2.1	2.2	1.4	-2.6	2.6
Novelty place preference	2.3	3.0	4.7	1.6	1.6	1.7	1.0	-2.1	2.2
Time in novel zone, NPP test	2.7	3.3	4.7	1.7	1.8	1.8	1.1	-2.1	2.2
Total zone transitions, NPP test	0.3	0.5	2.0	-0.1	0.0	-0.0	-0.2	-0.9	1.4
Total locomotion distance, NPP test	0.4	0.5	2.2	-0.0	0.0	0.1	-0.4	-1.0	1.5
Locomotion velocity, NPP test	0.3	0.4	1.6	-0.3	-0.3	-0.3	-0.6	-0.7	1.3
Intraocular pressure	0.4	0.6	2.2	0.1	0.1	-0.0	0.9	0.9	-1.5
Delta distance traveled before/after self-admin	0.4	0.4	0.4	-0.6	-0.6	-0.6	-0.6	0.7	-0.6
Delta ambulatory time before/after self-admin	0.2	0.4	0.6	-0.6	-0.6	-0.6	-0.8	0.5	-0.4
Parametrial fat weight	0.0	0.0	0.2	-0.1	-0.0	-0.0	-0.2	-0.2	0.4
Pavlov. Cond. lever latency	0.3	0.4	1.5	0.1	0.0	0.0	0.6	0.8	-1.2
Pavlov. Cond. magazine entry latency	2.7	3.5	4.2	-2.1	-2.0	-2.1	-1.8	1.8	-1.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2	0.1	0.0
Pavlov. Cond. index score	0.3	0.4	0.8	-0.8	-0.7	-0.7	-0.9	0.2	0.1
Pavlov. Cond. latency score	0.4	0.5	1.0	-0.7	-0.7	-0.7	-1.0	0.0	0.5
Pavlov. Cond. lever contacts	0.3	0.3	1.2	-0.1	-0.0	0.0	-0.5	-0.7	1.1
Pavlov. Cond. magazine entry number	0.7	0.9	1.1	1.0	1.0	1.0	0.8	-0.9	0.7
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.1	-0.3	-0.4	-0.4	0.1	0.8	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.9	-0.9	-0.8	-0.8	-1.0	0.4	-0.0
Pavlov. Cond. response bias	0.7	0.8	1.1	-1.0	-1.0	-1.0	-0.9	0.8	-0.6
Pavlov. Cond. lever latency	0.8	1.1	1.3	1.0	1.0	1.0	1.2	-1.1	0.9
Pavlov. Cond. magazine entry latency	0.3	0.5	0.7	-0.7	-0.7	-0.7	-0.8	0.7	-0.6
Pavlov. Cond. change in total contacts	0.4	0.9	1.3	-0.9	-0.9	-0.9	-0.9	1.1	-1.1
Pavlov. Cond. index score	0.6	0.9	1.1	-0.9	-0.9	-0.9	-1.0	1.1	-1.0
Pavlov. Cond. latency score	0.6	0.9	1.3	-0.9	-1.0	-0.9	-1.1	1.0	-0.8
Pavlov. Cond. lever contacts	0.6	0.9	1.2	-0.8	-0.9	-0.8	-0.9	1.1	-1.1
Pavlov. Cond. magazine entry number	0.6	0.8	1.3	0.9	0.9	0.9	1.1	-0.9	0.7
Pavlov. Cond. intertrial magazine entries	0.2	0.4	0.8	0.7	0.6	0.6	0.9	-0.2	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	1.3	-0.9	-1.0	-0.9	-1.1	1.0	-0.8
Pavlov. Cond. response bias	1.7	2.3	2.9	-1.4	-1.5	-1.5	-1.4	1.7	-1.6
Time in closed arm before self-admin	0.5	0.8	2.1	0.6	0.6	0.7	0.2	-1.2	1.5
Time in closed arm after self-admin	0.2	0.2	0.6	-0.3	-0.3	-0.4	-0.0	0.6	-0.8
Time in open arm before self-admin	0.2	0.2	0.5	-0.5	-0.4	-0.4	-0.7	0.4	-0.2
Time in open arm after self-admin	0.8	0.9	1.1	1.0	1.0	1.0	0.9	-0.9	0.7
Bone: periosteal estimation	0.3	0.7	1.9	0.6	0.6	0.7	-0.1	-1.2	1.4
Bone: periosteal perimeter	0.2	0.3	1.1	-0.4	-0.4	-0.3	-1.0	-0.2	0.6
Bone: post-yield work	0.5	0.8	1.1	1.0	1.0	1.0	0.9	-0.8	0.5
Progressive ratio test 1 active lever presses	0.2	0.4	1.3	-0.1	-0.2	-0.2	0.3	0.8	-1.1
Progressive ratio test 1 breakpoint	0.2	0.3	1.3	-0.1	-0.1	-0.2	0.3	0.8	-1.1
Progressive ratio test 1 inactive lever presses	0.2	0.4	0.8	-0.5	-0.5	-0.5	-0.2	0.8	-0.9
Progressive ratio test 2 active lever presses	0.6	0.8	2.5	-0.4	-0.5	-0.5	0.1	1.3	-1.6
Progressive ratio test 2 breakpoint	0.7	0.9	2.6	-0.5	-0.5	-0.6	0.1	1.3	-1.6
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.3	-0.4	-0.4	-0.4	-0.2	0.5	-0.5
Incentive Sensitization - Responses	0.1	0.4	1.1	0.1	0.1	0.0	0.7	0.7	-1.0
Incentive Sensitization - Breakpoint	0.1	0.3	1.0	-0.0	-0.0	-0.1	0.6	0.7	-1.0
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	0.1	0.1	0.1	-0.0	0.0
Progressive ratio	0.1	0.4	1.4	0.6	0.6	0.6	1.2	-0.3	-0.0
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.5	-0.4	-0.5	-0.1	0.1	0.0
Seeking ratio, punishment vs. effort	0.2	0.3	0.8	-0.7	-0.6	-0.6	-0.9	0.2	0.1
Retroperitoneal fat weight	0.4	1.7	4.2	1.4	1.4	1.3	2.1	-0.7	0.0
Reaction time number correct	0.2	0.7	1.6	0.9	0.8	0.8	1.3	0.1	-0.8
Reaction time mean minus median	0.1	0.8	1.0	-0.8	-0.9	-0.9	-0.8	1.0	-0.9
Reaction time mean minus median AUC	0.0	0.2	0.5	0.0	0.0	0.1	-0.5	-0.5	0.7
Reaction time num false alarms	0.1	0.2	0.4	0.5	0.4	0.4	0.5	0.3	-0.7
Reaction time num false alarms AUC	0.1	0.3	0.6	0.5	0.4	0.4	0.7	0.3	-0.8
Reaction time trials correct on left	0.2	0.7	1.6	0.9	0.8	0.8	1.3	0.1	-0.8
Reaction time trials on left	0.2	0.7	1.6	0.9	0.8	0.8	1.2	0.1	-0.7
Reaction time mean	0.0	0.1	0.3	0.1	0.1	0.2	-0.3	-0.4	0.6
Reaction time mean AUC	0.1	0.1	0.4	0.2	0.2	0.2	-0.2	-0.5	0.6
Median of all reaction times	0.3	0.5	1.0	0.6	0.6	0.6	0.1	-0.9	1.0
Reaction time omissions	0.1	0.2	0.4	-0.5	-0.5	-0.4	-0.6	-0.0	0.4
Reaction time false alarm rate	0.0	0.0	0.0	0.2	0.2	0.2	0.1	-0.1	0.0
Reaction time premature initiation rate	0.9	1.4	2.0	-1.1	-1.2	-1.2	-0.8	1.4	-1.4
Reaction time premature initiations	0.5	1.4	3.7	-0.8	-0.8	-0.9	-0.2	1.6	-1.9
Std. dev. reaction times	0.0	0.2	0.3	-0.4	-0.4	-0.4	-0.5	0.4	-0.2
Reaction time trials completed	0.2	0.7	1.6	0.9	0.8	0.8	1.2	0.1	-0.7
Reaction time trials AUC	0.2	0.8	1.8	0.9	0.8	0.8	1.3	0.2	-0.9
Run reversals in cocaine runway, females	0.5	0.5	1.1	-0.8	-0.8	-0.8	-1.0	0.4	-0.0
Run reversals in cocaine runway, males	1.3	1.4	2.2	-1.4	-1.4	-1.3	-1.5	0.8	-0.4
Latency to leave start box in cocaine runway	0.5	0.7	1.9	-0.9	-0.8	-0.8	-1.4	0.2	0.4
Latency to leave start box in cocaine runway, F	0.5	0.6	2.1	-0.1	-0.0	0.0	-0.8	-0.8	1.4
Latency to leave start box in cocaine runway, M	2.0	1.9	2.4	-1.4	-1.4	-1.4	-1.1	1.5	-1.5
Std. dev. time between licks in bursts	0.5	0.9	2.2	-1.0	-1.0	-1.0	-1.5	0.6	-0.3
Total sessions with >9 infusions	0.4	0.5	1.1	-0.5	-0.5	-0.5	-0.2	0.9	-1.0
Short access day 1 total inactive lever presses	0.2	0.4	0.6	-0.6	-0.6	-0.6	-0.3	0.7	-0.7
Short access day 10 total inactive lever presses	0.0	0.2	0.5	0.0	0.0	-0.0	0.5	0.5	-0.7
Short access day 1 total infusions	0.2	0.3	0.4	-0.6	-0.6	-0.6	-0.5	0.6	-0.6
Short access day 10 total infusions	0.1	0.2	0.8	-0.2	-0.2	-0.2	0.2	0.7	-0.9
Short access total infusions	0.3	0.4	0.8	-0.5	-0.6	-0.6	-0.3	0.9	-0.9
Short access day 1 locomotion	1.0	1.7	2.1	-1.3	-1.3	-1.3	-1.1	1.5	-1.3
Short access day 10 total locomotion	2.0	8.2	11.4	-2.8	-2.8	-2.9	-2.0	3.4	-3.2
Short access total locomotion	2.0	3.0	4.1	-1.7	-1.7	-1.7	-1.3	2.0	-1.9
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.1	0.1	0.1	0.3	0.2	-0.3
Compulsive drug intake	1.1	1.6	3.6	1.0	1.0	1.1	0.4	-1.6	1.9
One hour access (shock baseline)	0.3	0.8	2.1	-0.6	-0.7	-0.7	-0.3	1.2	-1.5
Social response proportion	0.6	0.7	1.1	-1.0	-1.0	-1.0	-1.1	0.5	-0.1
Social responses	6.2	8.2	11.4	-3.2	-3.1	-3.1	-3.4	2.4	-1.5
Social time	0.4	0.6	0.9	0.7	0.8	0.7	0.9	-0.7	0.6
Soleus weight	7.7	22.6	27.3	5.2	5.2	5.2	4.7	-4.5	3.4
Bone: stiffness	2.3	4.2	4.9	2.1	2.1	2.2	1.5	-2.2	2.0
Tibialis anterior weight	1.0	3.3	4.0	2.0	2.0	2.0	1.9	-1.7	1.2
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	0.0	0.2
Time to tail flick, vehicle, after self-admin	0.4	0.8	2.5	-0.4	-0.5	-0.5	0.3	1.2	-1.6
Time to tail flick, test, before self-admin	0.3	0.3	1.1	-0.6	-0.6	-0.5	-1.0	0.1	0.3
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.4	0.5	0.5	0.4	1.2	0.3	-0.9
Delta time to tail flick, test, before/after SA	0.2	0.2	0.8	0.1	0.1	0.0	0.6	0.5	-0.9
Tibia length	0.8	2.3	2.5	-1.6	-1.6	-1.6	-1.4	1.6	-1.3
Ambulatory time before self-admin	0.0	0.1	0.3	0.3	0.4	0.4	0.3	-0.4	0.5
Ambulatory time after self-admin	0.0	0.0	0.0	-0.1	-0.0	-0.0	-0.2	-0.1	0.2
Bone: tissue strength	1.8	1.9	2.2	1.4	1.4	1.4	1.2	-1.5	1.4
Total heroin consumption	1.3	1.6	2.1	-1.4	-1.4	-1.4	-1.4	1.1	-0.6
Bone: trabecular number	0.4	0.7	1.9	-0.8	-0.8	-0.7	-1.4	-0.0	0.5
Bone: trabecular spacing	0.7	1.1	2.7	0.8	0.7	0.6	1.6	0.5	-1.3
Bone: trabecular thickness	1.3	1.8	6.2	-0.0	0.1	0.2	-1.5	-1.6	2.5
Bone: trabecular tissue density	1.0	1.7	2.8	1.4	1.4	1.4	1.7	-1.1	0.7
Water consumed over 24 hours	0.5	0.9	1.3	0.9	1.0	1.0	0.5	-1.1	1.1
Number of responses in last shaping day	1.5	2.0	2.9	-1.3	-1.3	-1.3	-0.9	1.7	-1.7