Hub : Genes

Csnk1d

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative polyA NM_001414039.1 0.02 0.02 3.0e-03 0.02 0.02 0.02 0.02 3.3e-03 2.0e-03 2.4e-03 2.5e-03
2 Adipose alternative polyA XM_039086796.1 0.03 0.02 1.7e-03 0.02 0.02 0.02 0.02 2.2e-03 1.2e-03 2.2e-03 2.1e-03
3 Liver intron excision ratio chr10_106227740_106228787 0.03 0.03 9.1e-03 0.01 0.01 0 0.01 1.5e-02 5.5e-02 7.5e-02 6.3e-02
4 Liver mRNA stability Csnk1d 0.02 0.02 3.6e-03 0.02 0.01 0.02 0.01 4.2e-03 1.6e-02 3.6e-03 1.5e-02
5 Brain mRNA stability Csnk1d 0.08 0.05 7.1e-07 0.06 0.07 0.06 0.07 7.1e-06 5.4e-07 1.3e-06 8.0e-07
6 Liver gene expression Csnk1d 0.03 0.02 4.1e-04 0.01 0.02 0.02 0.01 1.0e-02 9.6e-04 3.5e-03 2.2e-02
7 NAcc intron excision ratio chr10_106228849_106231835 0.02 0.01 6.3e-03 0.01 0.01 0.01 0.01 5.0e-02 7.5e-03 1.6e-02 6.7e-02
8 PL gene expression Csnk1d 0.06 0.03 8.6e-07 0.06 0.06 0.06 0.06 2.9e-07 6.3e-07 4.2e-07 8.2e-07
9 Liver isoform ratio NM_001414039.1 0.03 0.02 2.3e-04 0.03 0.03 0.03 0.03 9.5e-05 2.0e-04 4.5e-04 9.8e-05
10 Brain alternative polyA XM_039086796.1 0.04 0.03 1.6e-03 0.03 0.03 0.03 0.03 6.8e-04 9.7e-04 1.3e-03 2.0e-03
11 Brain alternative polyA NM_001414039.1 0.04 0.03 1.6e-03 0.03 0.03 0.03 0.02 4.4e-04 1.1e-03 1.6e-03 2.6e-03
12 NAcc isoform ratio NM_001414039.1 0.03 0.02 3.7e-03 0 0.01 0 0 1.8e-01 1.9e-02 1.6e-01 1.5e-01
13 OFC gene expression Csnk1d 0.24 0.13 6.2e-04 0.07 0.01 0.01 0.04 1.2e-02 1.6e-01 2.2e-01 4.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.20.6-0.40.40.5-0.20.70.4-0.20.70.8-0.40.4-0.10.3
Area under the delay curve1.81.92.61.4-1.4-1.3-1.1-1.2-1.41.3-1.4-1.51.6-1.61.3-1.6
BMI with tail0.51.52.7-1.51.51.51.11.71.2-0.81.31.3-0.70.7-0.5-1.6
BMI without tail5.511.322.5-3.43.44.41.14.73.5-2.53.23.1-3.83.8-2.52.8
Body weight3.113.218.6-4.34.34.33.74.14.0-3.53.43.3-3.53.5-3.1-0.5
Weight adjusted by age2.12.33.3-1.81.81.41.81.21.7-1.71.41.3-1.61.6-1.60.8
Bone surface0.30.61.7-0.60.60.60.20.60.7-0.60.90.9-0.90.9-0.61.3
Bone volume0.30.51.3-0.60.60.70.10.70.7-0.50.80.9-0.70.7-0.51.1
Breakpoint value in progressive ratio session0.70.84.0-0.60.60.22.0-0.10.5-0.8-1.3-1.20.2-0.2-0.8-0.6
Number of licking bursts0.10.10.4-0.20.10.4-0.40.70.20.00.50.5-0.40.40.10.4
Context. condit. distance diff. score0.70.82.4-0.50.51.0-1.01.60.6-0.00.80.9-1.41.4-0.00.7
Locomotion velocity, session 11.71.84.81.3-1.3-1.8-0.4-2.2-1.40.9-1.5-1.51.3-1.30.8-1.0
Locomotion distance, session 12.43.14.91.9-2.0-1.7-2.1-1.1-2.02.2-1.1-1.01.5-1.52.2-1.9
Locomotion velocity, session 24.65.36.52.4-2.4-2.6-1.3-2.4-2.52.2-2.3-2.32.5-2.52.2-2.1
Locomotion distance, session 20.40.61.70.7-0.7-0.4-1.30.0-0.81.10.00.00.4-0.41.1-1.3
Locomotion velocity, session 32.12.53.61.5-1.5-1.8-0.1-1.9-1.61.3-1.8-1.81.5-1.51.3-1.9
Locomotion distance, session 33.94.26.52.1-2.1-2.1-0.7-1.9-2.22.0-2.3-2.32.0-2.02.0-2.5
Stereotopy head waving bouts, day 30.40.51.30.7-0.7-1.0-0.3-1.1-0.80.5-0.5-0.40.8-0.80.5-0.7
Stereotopy head waving duration, day 30.30.30.60.6-0.5-0.7-0.4-0.8-0.60.5-0.1-0.00.6-0.60.5-0.6
Locomotion velocity, session 70.90.91.21.1-1.1-1.1-0.8-0.8-1.11.1-1.0-0.90.9-0.91.1-0.7
Locomotion distance, session 72.83.65.52.2-2.2-1.7-2.2-1.1-2.12.4-1.8-1.91.4-1.42.3-1.4
Stereotopy head waving bouts, day 70.20.20.6-0.40.40.30.10.40.4-0.30.70.8-0.30.3-0.2-0.2
Stereotopy head waving duration, day 70.30.40.8-0.70.70.50.60.50.6-0.60.90.9-0.40.4-0.50.0
Locomotion velocity, session 80.50.62.00.7-0.7-0.3-1.40.2-0.71.1-0.2-0.20.4-0.41.1-1.4
Locomotion distance, session 80.60.93.30.0-0.10.7-1.81.70.00.80.91.0-1.01.00.9-0.5
Degree of sensitization distance0.90.92.8-0.70.71.0-0.61.20.8-0.51.00.9-1.01.0-0.61.7
Degree of sensitization stereotypy0.40.40.6-0.70.70.60.50.70.7-0.50.80.8-0.60.6-0.4-0.2
Conditioned locomotion4.45.17.9-2.32.32.70.82.82.4-1.92.52.5-2.52.5-1.81.6
Cocaine response after cond. corrected0.10.20.60.1-0.1-0.20.5-0.5-0.2-0.1-0.7-0.80.3-0.3-0.1-0.5
Cocaine response after cond. not corrected0.60.61.50.7-0.6-0.60.2-0.8-0.70.5-1.2-1.20.8-0.80.4-0.8
Cocaine response before conditioning0.91.11.71.2-1.2-1.0-0.8-0.6-1.21.3-0.8-0.81.2-1.21.3-0.9
Saline control response2.93.85.1-2.12.12.21.62.12.1-1.91.91.9-1.81.8-1.91.6
Bone: connectivity density0.10.21.20.2-0.20.1-1.10.5-0.10.40.50.6-0.30.30.40.5
Bone: cortical apparent density2.53.34.42.0-1.9-2.1-0.7-2.1-2.01.7-2.0-2.11.8-1.81.7-1.3
Bone: cortical area5.68.513.5-3.53.53.03.72.73.0-2.93.23.1-2.12.1-2.4-2.1
Bone: cortical porosity1.01.15.1-1.11.10.52.3-0.50.9-1.60.10.1-0.00.0-1.50.2
Bone: cortical porosity1.11.24.0-1.31.30.72.0-0.11.1-1.60.50.5-0.30.3-1.60.5
Bone: cortical thickness5.28.516.7-3.53.52.74.12.22.9-2.93.03.0-1.81.8-2.4-3.3
Bone: cortical thickness1.92.25.4-1.81.81.22.01.11.4-1.41.61.6-0.70.7-1.0-2.3
Bone: cortical tissue density2.83.75.12.1-2.1-2.2-0.9-2.3-2.11.8-2.2-2.21.9-1.91.8-1.2
Condit. Reinf. active minus inactive responses2.42.73.6-1.81.81.90.81.81.8-1.61.61.6-1.91.9-1.51.2
Condit. Reinf. active-inactive response ratio0.90.91.2-1.11.11.10.71.11.1-0.91.01.0-1.11.1-0.80.3
Condit. Reinf. active responses4.65.67.6-2.52.42.71.02.62.5-2.22.32.3-2.82.8-2.22.0
Condit. Reinf. inactive responses1.51.72.7-1.21.21.50.41.41.3-1.21.11.1-1.61.6-1.21.6
Incentive salience index mean1.82.23.3-1.51.51.70.71.71.6-1.31.41.4-1.81.8-1.31.3
Condit. Reinf. lever presses0.10.10.30.2-0.20.1-0.40.4-0.10.3-0.1-0.2-0.30.30.30.5
Condit. Reinf. active minus inactive responses1.11.42.2-1.31.31.40.31.31.2-1.01.51.5-1.21.2-1.0-0.2
Condit. Reinf. active-inactive response ratio2.82.93.8-1.91.91.71.01.41.8-1.82.02.0-1.81.8-1.80.6
Condit. Reinf. active responses0.30.50.8-0.70.70.9-0.20.90.7-0.50.70.7-0.80.8-0.5-0.3
Condit. Reinf. inactive responses0.50.60.90.8-0.8-0.6-0.7-0.4-0.80.9-0.9-0.90.6-0.60.9-1.0
Condit. Reinf. lever presses0.20.30.8-0.40.40.7-0.40.90.5-0.20.70.7-0.70.7-0.20.3
Condit. Reinf. lever reinforcers received0.30.40.9-0.70.60.9-0.41.00.6-0.40.70.7-0.80.8-0.4-0.2
Conditioned reinforcement - actives0.10.10.40.1-0.20.1-0.50.4-0.10.30.70.7-0.30.30.40.2
Conditioned reinforcement - inactives1.11.21.7-1.31.31.31.31.11.2-1.30.40.4-1.31.3-1.30.4
Conditioned locomotion0.10.10.20.0-0.00.1-0.20.20.10.00.50.5-0.40.40.10.4
Patch foraging indifference point 0 sec0.10.10.7-0.20.20.10.80.30.3-0.30.0-0.0-0.50.5-0.30.4
Patch foraging indifference point AUC0.10.10.6-0.10.10.3-0.60.20.2-0.10.40.4-0.40.4-0.20.8
Delay disc. indifference point, 0s delay0.20.22.00.2-0.2-0.3-0.2-0.3-0.30.3-0.0-0.10.4-0.40.4-1.4
Delay disc. indifference point, 16s delay2.12.13.81.6-1.6-1.1-1.9-0.7-1.61.8-1.3-1.41.2-1.21.8-1.1
Delay disc. indifference point, 2s delay0.50.51.00.6-0.6-0.7-0.4-0.8-0.70.5-0.8-0.80.8-0.80.5-1.0
Delay disc. indifference point, 24s delay5.14.96.92.3-2.3-2.6-1.3-2.6-2.32.0-2.2-2.12.5-2.51.9-1.8
Delay disc. indifference point, 4s delay0.60.62.10.6-0.6-0.6-0.4-0.6-0.70.6-0.5-0.51.2-1.20.6-1.5
Delay disc. indifference point, 8s delay1.01.02.20.8-0.8-1.1-0.2-1.1-0.90.6-1.1-1.21.2-1.20.6-1.5
Indifference point function ln k1.21.75.41.2-1.2-1.3-0.3-1.0-1.31.3-0.9-1.01.4-1.41.5-2.3
Indifference point function log k1.21.75.41.2-1.2-1.3-0.3-1.0-1.31.3-0.9-1.01.4-1.41.5-2.3
Patch foraging total patch changes 0 sec0.10.10.5-0.20.20.20.70.40.3-0.20.00.0-0.50.5-0.20.3
Patch foraging total patch changes 12 sec0.10.10.8-0.20.20.10.40.10.3-0.4-0.1-0.1-0.40.4-0.50.9
Patch foraging total patch changes 18 sec0.10.10.30.3-0.3-0.1-0.40.2-0.20.4-0.1-0.2-0.10.10.30.5
Patch foraging total patch changes 24 sec0.40.50.9-0.80.80.61.00.80.8-0.70.50.5-0.60.6-0.70.9
Patch foraging total patch changes 6 sec0.40.61.1-0.80.80.60.80.50.8-0.90.80.7-0.80.8-0.91.1
Patch foraging time to switch 0 sec0.40.60.90.9-0.9-1.0-0.6-0.9-0.90.8-0.9-0.80.7-0.70.70.0
Patch foraging water rate 0 sec1.82.84.8-1.91.92.21.62.21.9-1.61.01.0-1.81.8-1.50.5
Patch foraging water rate 12 sec0.20.41.7-0.60.50.80.21.00.4-0.10.20.2-0.50.50.1-1.3
Patch foraging water rate 18 sec0.40.62.0-0.70.71.10.11.40.6-0.20.90.9-0.70.7-0.0-0.6
Patch foraging water rate 24 sec1.31.84.9-1.51.51.90.62.21.4-0.81.01.0-1.51.5-0.7-0.1
Patch foraging water rate 6 sec0.30.54.6-0.30.30.50.60.60.10.2-0.5-0.5-0.20.20.4-2.2
Seeking ratio, delayed vs. immediate footshock1.51.72.4-1.41.41.40.61.61.4-1.21.41.5-1.31.3-1.20.5
Distance traveled before self-admin1.01.13.0-1.21.30.61.70.31.2-1.50.50.5-0.70.7-1.40.7
Distance traveled after self-admin0.70.83.5-0.60.50.80.11.00.8-0.60.50.6-1.01.0-0.71.9
Extensor digitorum longus weight0.10.51.6-0.10.10.6-1.01.30.20.41.11.1-0.60.60.4-0.1
Bone: elastic displacement1.31.42.1-1.41.41.11.40.91.3-1.41.51.4-0.90.9-1.20.2
Bone: elastic work6.78.714.3-3.63.62.83.81.93.2-3.53.13.1-2.22.2-3.30.0
Bone: endosteal estimation0.10.20.90.2-0.20.3-0.70.6-0.00.3-0.1-0.1-0.30.30.30.9
Bone: endosteal perimeter0.61.22.4-1.11.11.11.01.11.2-1.11.01.0-1.01.0-1.11.5
Epididymis fat weight0.61.53.2-1.41.41.60.91.81.4-1.01.11.0-1.21.2-0.90.4
Delta time in closed arm before/after self-admin0.10.10.30.4-0.4-0.1-0.50.1-0.30.5-0.3-0.3-0.20.20.4-0.1
Delta time in open arm before/after self-admin0.10.10.20.1-0.1-0.10.3-0.1-0.10.1-0.5-0.50.1-0.10.20.4
Diff in mean of infusions in LGA sessions0.80.92.20.8-0.7-0.70.3-0.9-0.70.5-1.3-1.31.5-1.50.5-0.2
Delay discount exponential model param2.52.63.7-1.61.61.61.11.51.6-1.41.61.7-1.91.9-1.41.8
Extinction: sum of active levers before priming2.02.03.61.2-1.2-1.6-0.2-1.9-1.41.1-1.4-1.41.8-1.81.2-1.4
Active lever presses in extinction session 61.81.85.00.5-0.4-1.01.6-1.4-0.70.2-2.1-2.11.1-1.10.4-2.2
Bone: final force5.18.312.4-3.53.53.23.22.93.1-2.93.03.0-2.22.2-2.4-1.9
Bone: final moment5.99.614.3-3.83.83.33.52.93.3-3.23.23.2-2.42.4-2.7-1.6
Food consumed during 24 hour testing period0.50.61.4-0.60.60.7-0.20.70.7-0.60.80.8-0.90.9-0.61.2
Glucose2.74.111.81.4-1.4-2.40.8-3.4-1.70.7-2.6-2.62.4-2.40.6-1.6
Heart weight0.60.82.0-1.11.10.80.50.60.9-0.91.41.3-0.70.7-0.8-0.4
Delay discount hyperbolic model param2.42.53.6-1.51.51.61.11.51.6-1.41.61.7-1.91.9-1.41.8
Intermittent access intake day 1-15 change1.11.12.4-1.01.01.01.30.91.1-1.20.20.2-1.21.2-1.31.6
Intermittent access intake escalation1.01.02.9-0.80.80.90.91.01.0-1.00.20.2-1.21.2-1.11.7
Intermittent access intake escalation 22.02.05.8-1.51.50.92.40.81.5-1.80.10.1-0.90.9-1.91.8
Intermitt. access day 1 inactive lever presses0.91.02.7-1.21.20.91.60.81.1-1.30.00.0-0.90.9-1.30.4
Intermitt. access day 15 inactive lever presses0.80.91.7-1.00.91.20.11.31.0-0.70.70.7-1.11.1-0.70.8
Intermitt. access escalation Index1.21.12.3-0.60.61.1-0.71.40.7-0.31.31.3-1.31.3-0.41.5
Intermittent access day 1 total infusions0.60.71.5-0.70.70.8-0.20.90.7-0.61.21.2-1.21.2-0.60.2
Intermittent access day 15 total infusions1.01.12.4-0.90.91.10.21.21.0-0.90.90.9-1.51.5-0.91.2
Intermittent access terminal intake (last 3 days)1.51.62.8-1.21.21.20.71.21.3-1.20.90.9-1.71.7-1.31.7
Intermittent access total infusions0.80.91.8-0.80.81.00.01.10.9-0.71.01.0-1.31.3-0.70.7
Intermittent access day 1 locomotion0.30.30.8-0.50.40.80.20.90.4-0.20.40.4-0.90.9-0.1-0.5
Intermittent access day 15 total locomotion0.60.71.5-0.70.70.70.80.70.8-0.80.80.8-1.21.2-0.80.6
Intermittent access total locomotion0.40.51.3-0.70.70.80.70.80.6-0.60.40.4-1.11.1-0.5-0.1
Intermittent access standard deviation1.21.33.60.4-0.3-1.11.5-1.3-0.5-0.1-1.9-1.91.1-1.1-0.0-1.4
Left kidney weight0.20.65.2-0.50.50.11.1-0.10.2-0.30.50.30.0-0.0-0.0-2.3
Right kidney weight0.30.89.5-0.10.1-0.20.6-0.1-0.20.20.30.10.1-0.10.5-3.1
Cocaine induced anxiety3.43.913.1-2.52.51.63.60.92.3-2.80.30.3-0.90.9-2.70.4
Post-drug Anxiety0.70.83.8-0.90.90.32.0-0.10.7-1.1-0.8-0.8-0.20.2-1.1-0.5
Baseline Anxiety6.06.49.83.0-3.0-2.6-2.8-2.1-3.03.1-1.8-1.81.9-1.93.1-2.0
Tail length5.717.325.6-4.14.15.02.15.14.4-3.63.63.5-4.94.9-3.74.1
Length with tail2.07.59.9-3.13.13.13.12.73.0-2.92.22.2-2.82.8-2.70.4
Length without tail1.12.314.00.3-0.3-1.42.0-1.9-0.70.0-1.2-1.11.4-1.40.3-3.7
Times rat made contact with spout2.12.511.5-1.21.20.90.60.41.4-1.71.21.2-1.51.5-1.93.4
Lifetime Intake0.20.30.7-0.40.40.5-0.10.60.4-0.30.50.5-0.80.8-0.30.5
Liver weight, left0.20.41.20.1-0.1-0.61.1-1.0-0.2-0.2-0.5-0.50.6-0.6-0.1-1.1
Liver weight, right1.42.23.3-1.71.71.81.61.61.7-1.61.41.4-1.41.4-1.4-0.1
Locomotor activity0.91.42.51.1-1.1-1.4-0.3-1.1-1.11.0-1.3-1.41.6-1.61.0-0.8
Locomotor testing distance1.32.13.71.5-1.5-1.7-0.9-1.1-1.51.5-1.2-1.21.9-1.91.6-1.0
Locomotor testing rearing0.50.81.41.0-1.0-0.8-0.7-0.5-0.90.9-1.2-1.20.9-0.90.80.4
Locomotion in novel chamber0.30.30.50.6-0.6-0.7-0.7-0.3-0.60.7-0.5-0.60.3-0.30.7-0.6
Locomotion in novel chamber post-restriction3.03.64.3-1.91.92.01.21.92.0-1.91.91.9-2.12.1-1.91.5
Fecal boli incidents, locomotor time 10.50.51.40.9-0.9-0.7-1.2-0.6-0.80.9-0.1-0.30.6-0.60.90.1
Change in fecal boli incidents, locomotor task1.91.84.11.1-1.1-1.60.7-1.9-1.10.6-2.0-1.91.5-1.50.5-0.6
Time >=10cm from walls, locomotor time 10.90.92.1-0.60.61.0-0.51.50.7-0.30.60.8-1.41.4-0.31.2
Bouts of movement, locomotor time 11.81.93.71.4-1.4-1.5-1.4-1.6-1.41.3-0.9-0.81.9-1.91.3-0.8
Total resting periods, locomotor time 12.02.24.01.5-1.5-1.6-1.3-1.8-1.51.3-1.0-0.92.0-2.01.3-0.9
Rest time, locomotor task time 10.20.20.60.4-0.3-0.6-0.1-0.8-0.40.1-0.3-0.30.7-0.70.10.0
Distance moved, locomotor task time 10.40.41.2-0.50.50.91.11.00.5-0.4-0.5-0.3-0.70.7-0.3-0.2
Vertical activity count, locomotor time 10.50.51.8-0.80.71.10.51.30.8-0.40.20.2-0.70.7-0.30.1
Time >=10cm from walls, locomotor time 20.40.41.4-0.30.30.2-0.70.40.2-0.11.11.2-0.70.7-0.0-0.7
Bouts of movement, locomotor time 21.31.41.91.2-1.2-1.0-1.4-0.8-1.21.2-1.2-1.21.2-1.21.2-1.3
Total resting periods, locomotor time 20.91.02.31.1-1.1-0.7-1.5-0.5-1.01.2-0.9-0.80.9-0.91.2-1.0
Rest time, locomotor task time 20.20.20.80.3-0.3-0.0-0.6-0.2-0.20.2-0.0-0.00.7-0.70.10.9
Distance moved, locomotor task time 20.20.22.0-0.10.10.00.20.2-0.00.1-0.2-0.0-0.20.20.2-1.4
Vertical activity count, locomotor time 20.20.21.8-0.20.20.3-0.40.70.00.30.20.1-0.40.40.5-1.3
Light reinforcement 10.81.43.4-1.11.01.40.11.81.2-0.71.31.3-1.31.3-0.61.5
Light reinforcement 21.41.93.5-1.51.51.70.91.91.6-1.21.41.3-1.21.2-1.11.0
Bone: marrow area0.10.20.70.2-0.20.3-0.70.6-0.00.3-0.2-0.2-0.30.30.30.9
Bone: maximum diameter1.22.24.4-1.81.81.52.11.51.6-1.41.61.6-0.90.9-1.1-0.8
Bone: maximum force5.39.113.6-3.73.73.42.93.13.2-3.03.23.3-2.42.4-2.5-1.7
Bone: maximum moment6.010.415.4-3.93.93.63.23.23.5-3.33.53.5-2.62.6-2.8-1.4
Mean time between licks in bursts1.72.43.31.7-1.7-1.5-0.9-1.3-1.71.7-1.8-1.81.5-1.51.6-1.3
Mean num. licks in bursts0.50.62.6-0.60.60.20.7-0.20.7-1.00.50.5-0.60.6-1.11.6
Cd content in liver1.81.93.41.4-1.4-1.3-1.2-1.1-1.51.5-1.2-1.31.3-1.31.5-1.8
Co content in liver0.20.30.50.6-0.6-0.6-0.1-0.4-0.50.5-0.7-0.70.4-0.40.60.2
Cu content in liver0.20.31.6-0.50.50.21.3-0.30.5-0.8-0.0-0.1-0.10.1-0.80.1
Fe content in liver1.21.42.61.3-1.3-1.3-0.6-1.0-1.31.2-1.5-1.61.1-1.11.2-0.3
K content in liver1.81.83.6-1.21.11.50.01.91.3-0.91.31.3-1.61.6-0.91.7
Mg content in liver0.50.61.8-0.0-0.00.6-1.31.30.20.40.40.5-0.80.80.31.1
Mn content in liver0.20.20.4-0.60.60.50.30.50.6-0.60.60.5-0.40.4-0.5-0.1
Na content in liver0.00.00.10.1-0.1-0.20.0-0.1-0.10.0-0.3-0.30.1-0.10.10.3
Rb content in liver1.11.32.6-1.11.11.4-0.41.61.1-0.71.41.4-1.31.3-0.70.5
Se content in liver0.50.63.1-0.50.50.7-0.10.80.7-0.60.50.5-1.01.0-0.61.8
Sr content in liver0.30.31.40.0-0.0-0.61.0-1.2-0.1-0.4-0.1-0.10.5-0.5-0.50.3
Zn content in liver0.00.00.10.2-0.2-0.0-0.0-0.1-0.20.1-0.3-0.30.1-0.10.1-0.1
Bone: minimum diameter2.64.87.7-2.62.52.32.82.12.4-2.32.32.3-1.91.9-2.00.3
Time in familiar zone, hab. session 10.00.00.1-0.20.2-0.00.2-0.30.1-0.2-0.1-0.1-0.10.1-0.3-0.3
Time in novel zone, hab. session 10.00.00.00.1-0.10.1-0.20.2-0.00.20.20.10.0-0.00.20.1
Total zone transitions, hab. session 10.30.41.00.6-0.6-0.5-0.7-0.4-0.70.8-0.3-0.20.6-0.60.8-1.0
Total locomotion distance, hab. session 10.10.20.7-0.10.10.3-0.30.60.10.20.80.8-0.30.30.3-0.3
Locomotion velocity, hab. session 10.10.20.7-0.10.10.3-0.30.60.10.20.80.8-0.30.30.3-0.1
Time in familiar zone, hab. session 20.30.30.60.6-0.6-0.5-0.3-0.3-0.50.6-0.7-0.80.3-0.30.6-0.0
Time in novel zone, hab. session 20.10.10.60.0-0.0-0.1-0.2-0.1-0.10.10.20.20.3-0.30.2-0.7
Total zone transitions, hab. session 20.40.63.20.5-0.50.0-1.80.6-0.41.00.70.7-0.00.01.0-0.6
Total locomotion distance, hab. session 20.70.92.6-0.40.31.0-1.21.60.50.21.51.5-0.90.90.30.3
Locomotion velocity, hab. session 20.91.23.2-0.70.61.2-0.91.80.7-0.11.71.7-1.11.10.00.3
Novel to familiar place preference ratio2.72.84.3-2.02.01.62.01.01.8-2.11.61.6-1.41.4-2.00.4
Novelty place preference2.62.64.2-1.91.91.51.90.91.8-2.01.51.6-1.31.3-2.00.3
Time in novel zone, NPP test2.12.23.3-1.81.81.41.70.91.6-1.81.41.5-1.21.2-1.70.3
Total zone transitions, NPP test0.70.94.51.0-1.0-0.3-2.10.6-0.81.50.00.00.2-0.21.5-0.5
Total locomotion distance, NPP test0.50.62.80.2-0.30.5-1.71.4-0.10.80.80.8-0.50.50.90.1
Locomotion velocity, NPP test0.40.51.8-0.00.00.6-1.21.40.20.50.90.9-0.70.70.50.2
Intraocular pressure0.81.12.1-1.01.01.40.31.31.1-0.91.00.9-1.31.3-0.90.9
Delta distance traveled before/after self-admin0.40.41.10.8-0.8-0.2-1.10.2-0.61.0-0.5-0.50.2-0.20.80.6
Delta ambulatory time before/after self-admin1.11.22.21.4-1.4-0.7-1.5-0.3-1.21.5-0.9-0.90.7-0.71.30.5
Parametrial fat weight1.73.34.9-1.91.92.01.31.81.9-1.81.61.7-2.22.2-1.71.3
Pavlov. Cond. lever latency0.81.12.91.1-1.1-0.6-1.7-0.0-1.01.5-0.7-0.70.7-0.71.5-1.0
Pavlov. Cond. magazine entry latency2.33.06.8-1.91.91.42.60.81.9-2.20.90.9-1.51.5-2.21.4
Pavlov. Cond. change in total contacts0.40.53.3-0.50.5-0.01.8-0.50.4-0.9-0.2-0.3-0.20.2-0.90.2
Pavlov. Cond. index score2.83.65.8-2.12.11.72.41.22.1-2.31.51.4-1.81.8-2.31.6
Pavlov. Cond. latency score2.22.85.0-1.81.81.42.20.81.8-2.11.31.2-1.51.5-2.11.6
Pavlov. Cond. lever contacts0.60.71.7-0.80.80.61.30.30.8-1.10.60.5-0.70.7-1.00.9
Pavlov. Cond. magazine entry number2.22.77.91.8-1.9-1.2-2.8-0.3-1.72.2-0.7-0.71.3-1.32.3-1.3
Pavlov. Cond. intertrial magazine entries0.40.51.2-0.50.40.9-0.71.10.5-0.20.80.8-0.90.9-0.20.7
Pavlov. Cond. lever-magazine prob. diff.2.93.66.6-2.12.11.72.61.22.1-2.31.41.3-1.81.8-2.31.4
Pavlov. Cond. response bias1.92.36.7-1.71.71.22.60.51.6-2.00.70.7-1.21.2-2.01.0
Pavlov. Cond. lever latency0.60.81.70.7-0.7-1.00.6-1.3-0.80.4-1.1-1.10.9-0.90.4-1.1
Pavlov. Cond. magazine entry latency1.82.13.21.6-1.7-1.2-1.8-0.7-1.51.8-1.3-1.31.5-1.51.7-0.4
Pavlov. Cond. change in total contacts0.20.20.90.5-0.5-0.3-1.00.1-0.40.7-0.4-0.40.2-0.20.7-0.0
Pavlov. Cond. index score0.20.21.20.5-0.5-0.2-1.10.2-0.40.6-0.2-0.20.3-0.30.60.4
Pavlov. Cond. latency score0.20.21.30.4-0.4-0.0-1.10.3-0.30.6-0.1-0.10.2-0.20.60.5
Pavlov. Cond. lever contacts1.01.32.6-0.90.91.3-0.71.61.0-0.61.41.4-1.21.2-0.61.5
Pavlov. Cond. magazine entry number1.41.72.6-1.51.51.01.60.51.4-1.61.31.3-1.21.2-1.60.4
Pavlov. Cond. intertrial magazine entries2.12.73.6-1.81.81.90.71.71.7-1.61.81.8-1.91.9-1.50.8
Pavlov. Cond. lever-magazine prob. diff.0.30.41.50.7-0.7-0.3-1.20.1-0.50.8-0.4-0.40.4-0.40.70.4
Pavlov. Cond. response bias0.10.20.9-0.10.10.5-1.00.80.20.10.30.3-0.20.20.10.5
Time in closed arm before self-admin0.10.20.5-0.10.1-0.40.5-0.6-0.0-0.3-0.0-0.00.5-0.5-0.2-0.7
Time in closed arm after self-admin0.60.61.60.5-0.5-1.00.5-1.3-0.60.1-1.2-1.20.8-0.80.0-0.8
Time in open arm before self-admin0.30.31.60.5-0.5-0.3-1.3-0.0-0.50.70.50.50.1-0.10.7-0.1
Time in open arm after self-admin0.20.20.60.5-0.5-0.3-0.6-0.1-0.50.7-0.2-0.20.2-0.20.8-0.0
Bone: periosteal estimation1.63.44.7-2.22.22.12.02.12.0-1.72.01.9-1.51.5-1.4-0.6
Bone: periosteal perimeter2.74.59.8-2.62.62.03.11.52.3-2.52.02.0-1.51.5-2.2-0.2
Bone: post-yield work0.10.10.40.1-0.10.2-0.60.4-0.10.4-0.0-0.0-0.10.10.4-0.6
Progressive ratio test 1 active lever presses1.11.21.9-1.01.01.40.61.31.1-1.00.90.9-1.31.3-0.91.2
Progressive ratio test 1 breakpoint1.61.72.4-1.21.21.60.71.51.3-1.21.11.1-1.51.5-1.21.5
Progressive ratio test 1 inactive lever presses2.02.23.8-1.61.61.91.11.91.6-1.41.21.2-1.61.6-1.30.6
Progressive ratio test 2 active lever presses0.60.61.2-0.70.70.80.40.80.8-0.70.70.7-1.01.0-0.81.1
Progressive ratio test 2 breakpoint0.70.81.3-0.70.70.90.21.10.8-0.70.80.8-1.11.1-0.71.2
Progressive ratio test 2 inactive lever presses0.40.40.7-0.80.80.50.80.60.7-0.80.20.2-0.80.8-0.80.2
Incentive Sensitization - Responses0.60.72.0-0.60.60.6-0.00.70.7-0.61.01.0-0.80.8-0.81.4
Incentive Sensitization - Breakpoint0.50.51.9-0.60.60.50.00.50.6-0.60.90.9-0.70.7-0.71.4
Sum of active levers in priming session hrs 5-60.80.82.9-1.01.00.61.70.20.9-1.2-0.6-0.5-0.70.7-1.20.4
Progressive ratio0.50.61.10.8-0.8-0.8-1.1-0.8-0.80.8-0.8-0.80.6-0.60.7-0.7
Food seeking constrained by brief footshock0.10.10.70.4-0.3-0.5-0.3-0.8-0.30.0-0.3-0.30.4-0.4-0.00.2
Seeking ratio, punishment vs. effort0.20.30.7-0.40.40.50.30.50.5-0.40.60.6-0.50.5-0.40.8
Retroperitoneal fat weight3.912.915.6-3.83.83.92.63.93.9-3.53.63.4-3.83.8-3.43.1
Reaction time number correct0.50.83.30.2-0.30.7-1.81.6-0.11.10.60.5-0.60.61.1-0.2
Reaction time mean minus median0.20.30.80.3-0.3-0.60.6-0.9-0.3-0.0-0.6-0.60.8-0.8-0.10.3
Reaction time mean minus median AUC0.00.00.20.0-0.0-0.10.0-0.3-0.0-0.1-0.0-0.00.5-0.5-0.10.1
Reaction time num false alarms0.20.20.30.5-0.5-0.6-0.4-0.6-0.50.5-0.5-0.40.3-0.30.40.2
Reaction time num false alarms AUC0.50.71.01.0-1.0-0.9-0.8-0.8-1.01.0-0.7-0.60.7-0.70.9-0.1
Reaction time trials correct on left0.50.83.30.2-0.30.7-1.81.6-0.11.10.60.5-0.60.61.1-0.2
Reaction time trials on left0.60.83.50.2-0.30.7-1.91.6-0.11.10.60.5-0.50.51.2-0.2
Reaction time mean0.20.30.5-0.60.50.50.00.50.6-0.50.60.6-0.60.6-0.50.7
Reaction time mean AUC0.20.30.7-0.40.40.5-0.40.60.4-0.20.80.8-0.40.4-0.20.6
Median of all reaction times0.30.30.5-0.60.60.7-0.20.70.6-0.40.70.7-0.70.7-0.40.4
Reaction time omissions0.00.10.40.0-0.00.1-0.10.40.10.10.20.20.1-0.10.10.6
Reaction time false alarm rate0.50.62.30.8-0.7-1.10.1-1.5-0.70.3-0.9-0.80.8-0.80.20.2
Reaction time premature initiation rate0.91.22.01.3-1.2-1.4-0.9-1.2-1.21.1-1.1-1.11.0-1.01.0-0.3
Reaction time premature initiations0.81.13.11.2-1.2-0.8-1.7-0.1-1.11.5-0.6-0.70.6-0.61.4-0.3
Std. dev. reaction times0.30.40.60.7-0.7-0.7-0.7-0.7-0.60.6-0.4-0.40.8-0.80.60.2
Reaction time trials completed0.60.83.50.2-0.30.7-1.91.6-0.11.10.60.5-0.50.51.2-0.2
Reaction time trials AUC0.60.83.30.2-0.20.7-1.81.7-0.11.00.70.6-0.70.71.1-0.1
Run reversals in cocaine runway, females0.50.52.60.8-0.8-0.8-1.6-0.2-0.70.9-0.3-0.30.5-0.50.80.3
Run reversals in cocaine runway, males1.61.53.9-1.31.30.82.00.41.3-1.60.80.8-0.90.9-1.61.5
Latency to leave start box in cocaine runway0.20.31.10.6-0.6-0.3-1.1-0.1-0.50.60.10.10.4-0.40.60.3
Latency to leave start box in cocaine runway, F0.60.63.10.8-0.8-0.3-1.80.2-0.61.00.60.60.6-0.61.10.1
Latency to leave start box in cocaine runway, M0.20.20.5-0.30.30.40.50.20.4-0.5-0.3-0.3-0.60.6-0.50.7
Std. dev. time between licks in bursts0.50.63.3-0.30.31.1-0.81.80.40.30.70.7-0.90.90.4-0.2
Total sessions with >9 infusions0.20.20.50.6-0.6-0.3-0.5-0.2-0.60.6-0.4-0.4-0.00.00.7-0.7
Short access day 1 total inactive lever presses0.20.21.10.3-0.30.0-1.10.5-0.30.60.20.2-0.10.10.7-0.3
Short access day 10 total inactive lever presses3.03.35.0-2.22.22.02.21.92.1-2.10.80.8-1.71.7-2.10.4
Short access day 1 total infusions1.92.02.61.5-1.5-1.5-0.7-1.5-1.51.4-1.6-1.61.3-1.31.4-1.1
Short access day 10 total infusions0.60.71.3-0.80.80.90.70.70.9-0.90.40.4-1.11.1-0.91.0
Short access total infusions0.00.00.10.0-0.00.1-0.10.10.0-0.0-0.1-0.1-0.40.4-0.00.3
Short access day 1 locomotion0.50.51.00.6-0.6-0.80.4-1.0-0.70.5-0.9-0.90.6-0.60.6-1.0
Short access day 10 total locomotion0.30.30.70.2-0.2-0.60.9-0.7-0.3-0.1-0.7-0.70.3-0.3-0.1-0.8
Short access total locomotion0.40.41.30.5-0.5-0.60.3-0.8-0.60.4-0.7-0.70.3-0.30.4-1.1
One hour access (0.3 mA shock)1.92.23.2-1.41.41.60.31.71.5-1.21.61.6-1.71.7-1.21.8
Compulsive drug intake0.40.40.8-0.70.70.70.20.70.6-0.50.90.9-0.40.4-0.40.3
One hour access (shock baseline)0.50.61.2-0.30.30.6-0.70.80.5-0.21.01.0-1.01.0-0.31.1
Social response proportion0.80.93.40.8-0.8-0.6-0.1-0.4-0.90.9-1.3-1.30.5-0.51.0-1.8
Social responses0.60.84.20.6-0.7-0.50.4-0.2-0.70.8-0.8-0.80.8-0.81.0-2.0
Social time0.30.42.40.4-0.4-0.3-0.1-0.1-0.50.7-0.4-0.40.7-0.70.8-1.6
Soleus weight1.44.06.2-2.12.02.20.92.22.1-1.82.52.5-1.91.9-1.81.7
Bone: stiffness0.91.56.5-1.41.41.31.21.31.0-0.81.01.1-0.40.4-0.5-2.5
Tibialis anterior weight0.10.40.9-0.10.10.5-0.80.80.30.10.90.9-0.50.5-0.01.0
Time to tail flick, vehicle, before self-admin0.20.20.9-0.30.30.4-0.50.40.3-0.20.90.9-0.40.4-0.20.7
Time to tail flick, vehicle, after self-admin2.32.43.21.7-1.7-1.6-1.4-1.4-1.71.7-0.8-0.91.8-1.81.8-1.7
Time to tail flick, test, before self-admin0.10.10.4-0.30.30.50.50.30.4-0.5-0.2-0.2-0.30.3-0.60.0
Time to tail flick, test, after self-admin0.60.71.40.8-0.8-0.80.0-0.7-0.80.7-1.2-1.20.6-0.60.7-1.1
Delta time to tail flick, vehicle, before/after SA0.50.51.00.8-0.8-0.5-1.0-0.2-0.80.9-0.3-0.40.6-0.60.9-0.3
Delta time to tail flick, test, before/after SA1.00.92.20.7-0.7-1.10.3-1.2-0.90.7-1.1-1.00.8-0.80.8-1.5
Tibia length8.423.834.9-5.95.95.15.24.05.4-5.55.25.2-4.04.0-5.1-0.1
Ambulatory time before self-admin1.92.03.7-1.71.71.11.90.81.6-1.90.80.9-1.21.2-1.70.8
Ambulatory time after self-admin0.30.41.4-0.40.40.50.50.60.6-0.50.10.1-0.80.8-0.51.2
Bone: tissue strength1.11.12.4-1.11.11.30.71.51.0-0.61.31.3-0.80.8-0.5-0.8
Total heroin consumption0.80.94.5-0.20.2-0.71.5-0.9-0.1-0.3-1.0-1.00.9-0.9-0.1-2.1
Bone: trabecular number0.10.10.5-0.10.10.1-0.50.20.1-0.00.40.5-0.20.2-0.10.7
Bone: trabecular spacing0.30.32.0-0.0-0.00.7-0.81.40.10.50.30.3-0.40.40.6-0.3
Bone: trabecular thickness0.60.72.2-0.90.90.41.5-0.30.8-1.30.30.3-0.40.4-1.30.5
Bone: trabecular tissue density0.91.31.91.2-1.2-1.1-0.9-1.1-1.21.1-1.3-1.41.0-1.01.1-1.0
Water consumed over 24 hours0.10.10.60.2-0.1-0.4-0.0-0.7-0.1-0.2-0.1-0.10.2-0.2-0.30.8
Number of responses in last shaping day0.70.71.5-0.80.80.81.00.90.7-0.50.60.6-1.21.2-0.4-0.9