Hub : Genes

Csnk1d

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Csnk1d 0.05 0.03 1.7e-09 0.07 0.06 0.07 0.07 5.4e-11 8.7e-10 2.8e-10 1.0e-10
2 IC gene expression Csnk1d 0.11 0.07 2.8e-04 0.12 0.07 0.06 0 7.1e-06 4.9e-04 2.4e-03 2.6e-01
3 NAcc isoform ratio NM_139060.3 0.02 0.01 6.3e-03 0 0.01 0.01 0.01 4.9e-02 5.2e-03 2.5e-03 4.9e-03
4 Brain mRNA stability Csnk1d 0.09 0.05 2.5e-08 0.07 0.08 0.08 0.06 2.0e-07 7.3e-08 9.3e-08 7.4e-06
5 Liver mRNA stability Csnk1d 0.03 0.02 2.4e-03 0.02 0.01 0.01 0.02 1.7e-03 9.1e-03 4.5e-02 5.7e-03
6 NAcc intron excision ratio chr10_106727190_106730176 0.02 0.02 5.2e-04 0.01 0.02 0.01 0.01 2.5e-03 1.2e-03 2.3e-03 4.2e-03
7 NAcc isoform ratio NM_001414039.1 0.02 0.02 2.3e-03 0.01 0.01 0.01 0.01 1.8e-02 2.0e-03 2.3e-03 3.2e-03
8 Liver isoform ratio NM_001414039.1 0.03 0.02 2.0e-04 0.03 0.03 0.03 0.03 2.0e-04 1.3e-04 1.0e-04 8.5e-04
9 pVTA isoform ratio NM_001414039.1 0.04 0.03 4.1e-03 0.01 0.01 0.01 0.01 8.9e-02 2.3e-02 5.7e-02 5.4e-02
10 PL gene expression Csnk1d 0.06 0.04 1.2e-06 0.04 0.04 0.04 0.03 2.2e-05 2.3e-05 6.2e-05 1.2e-04
11 pVTA intron excision ratio chr10_106726081_106730176 0.04 0.03 5.6e-03 0 0.01 0.01 0.01 1.1e-01 2.2e-02 6.0e-02 4.6e-02
12 Liver gene expression Csnk1d 0.02 0.01 6.7e-03 0.02 0.01 0.01 -0 2.1e-03 1.8e-02 3.6e-02 7.2e-01
13 OFC gene expression Csnk1d 0.21 0.12 1.7e-03 0.08 0.01 -0 0.04 7.0e-03 2.1e-01 3.6e-01 3.4e-02
14 Adipose isoform ratio NM_001414039.1 0.02 0.01 4.6e-03 0.03 0.01 0 0.01 8.3e-04 1.6e-02 7.4e-02 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.20.40.70.6-0.60.40.8-0.0-0.2-0.3-0.7-0.8-0.80.80.8-0.8-0.9
Area under the delay curve1.51.72.7-1.21.2-1.4-1.11.21.31.31.51.11.3-1.3-1.11.31.7
BMI with tail0.41.33.61.9-1.91.51.3-0.3-0.7-0.7-1.2-1.1-1.10.31.0-0.50.6
BMI without tail2.67.912.23.5-3.52.93.3-1.3-2.0-2.3-3.0-3.2-2.92.82.8-2.9-1.9
Body weight2.08.715.23.9-3.93.73.2-2.6-3.1-3.1-3.0-2.9-2.62.32.3-2.5-0.7
Weight adjusted by age1.72.73.61.9-1.91.91.5-1.4-1.6-1.6-1.8-1.4-1.91.31.8-1.5-1.1
Bone surface0.30.51.60.4-0.40.50.5-0.6-0.5-0.6-0.7-0.6-0.80.90.8-1.0-1.3
Bone volume0.30.61.60.6-0.60.60.7-0.5-0.5-0.6-0.7-0.8-0.90.90.8-1.1-1.3
Breakpoint value in progressive ratio session0.60.73.00.4-0.41.1-0.0-1.7-1.4-1.20.40.20.80.1-0.7-0.20.3
Number of licking bursts0.10.20.60.4-0.4-0.00.60.40.30.1-0.4-0.6-0.70.50.7-0.5-0.6
Context. condit. distance diff. score0.70.92.40.9-0.90.21.51.00.4-0.1-0.7-1.5-0.71.40.8-1.0-0.9
Locomotion velocity, session 11.92.04.3-1.51.5-0.9-2.1-0.00.60.91.42.11.3-2.0-1.31.41.4
Locomotion distance, session 12.32.94.9-1.51.5-2.0-1.22.12.22.21.31.21.2-1.8-1.21.81.9
Locomotion velocity, session 24.45.16.0-2.42.4-2.3-2.41.41.92.12.42.42.3-2.5-2.32.42.2
Locomotion distance, session 20.30.51.6-0.20.2-0.7-0.11.31.11.00.20.10.0-0.6-0.00.71.0
Locomotion velocity, session 32.32.63.7-1.71.7-1.5-1.90.41.01.31.71.91.8-1.9-1.81.61.8
Locomotion distance, session 34.34.76.1-2.12.1-2.1-2.11.31.82.12.42.12.4-2.3-2.42.32.5
Stereotopy head waving bouts, day 30.50.61.3-0.70.7-0.5-1.1-0.00.40.60.61.10.6-1.2-0.70.90.8
Stereotopy head waving duration, day 30.40.40.9-0.60.6-0.5-0.80.20.60.70.40.80.4-1.0-0.40.80.7
Locomotion velocity, session 70.91.01.8-1.31.3-1.4-0.80.71.11.11.10.81.1-0.6-1.10.90.6
Locomotion distance, session 72.93.66.3-1.81.8-2.4-1.12.32.52.42.01.02.1-1.3-2.01.71.4
Stereotopy head waving bouts, day 70.30.30.50.6-0.60.60.5-0.4-0.5-0.5-0.6-0.4-0.70.40.6-0.6-0.3
Stereotopy head waving duration, day 70.30.30.50.6-0.60.60.5-0.4-0.5-0.5-0.7-0.5-0.70.40.7-0.6-0.4
Locomotion velocity, session 80.50.62.6-0.20.2-0.80.11.61.31.10.4-0.00.3-0.5-0.40.71.2
Locomotion distance, session 80.71.14.30.8-0.8-0.41.52.11.30.8-0.6-1.5-0.70.90.7-0.40.1
Degree of sensitization distance1.01.02.20.9-0.90.51.30.1-0.2-0.6-0.9-1.4-0.91.51.0-1.1-1.5
Degree of sensitization stereotypy0.40.40.60.8-0.80.70.7-0.2-0.5-0.6-0.7-0.7-0.80.60.7-0.7-0.3
Conditioned locomotion4.35.07.42.4-2.42.02.7-0.6-1.4-1.8-2.3-2.7-2.42.62.4-2.4-2.1
Cocaine response after cond. corrected0.20.30.7-0.30.30.0-0.5-0.5-0.3-0.10.60.60.7-0.5-0.80.40.8
Cocaine response after cond. not corrected0.80.92.1-0.90.9-0.6-0.90.00.30.51.11.01.2-1.0-1.31.11.4
Cocaine response before conditioning1.01.22.1-1.01.0-1.5-0.61.31.41.40.90.61.0-0.7-0.91.21.0
Saline control response2.53.44.81.9-1.91.72.1-1.0-1.4-1.7-1.9-2.1-1.82.21.8-2.0-1.7
Bone: connectivity density0.20.30.70.0-0.0-0.40.50.80.50.3-0.3-0.6-0.50.60.5-0.4-0.7
Bone: cortical apparent density2.83.84.8-2.22.2-2.0-2.11.21.71.92.22.02.1-2.0-2.11.91.6
Bone: cortical area4.67.112.83.6-3.63.52.4-2.7-2.9-2.7-3.0-2.1-2.81.32.6-1.7-0.0
Bone: cortical porosity0.80.95.00.5-0.51.2-0.4-2.2-1.7-1.3-0.50.5-0.3-0.20.3-0.3-0.2
Bone: cortical porosity1.21.35.30.9-0.91.60.1-2.3-1.9-1.6-0.90.0-0.80.20.7-0.8-0.6
Bone: cortical thickness4.06.713.33.4-3.43.61.9-3.0-3.2-2.7-2.9-1.5-2.60.62.4-1.30.7
Bone: cortical thickness1.01.22.61.5-1.51.60.8-1.3-1.4-1.1-1.2-0.6-1.10.01.0-0.20.8
Bone: cortical tissue density3.14.25.4-2.32.3-2.1-2.21.31.82.02.32.12.2-2.0-2.21.91.5
Condit. Reinf. active minus inactive responses2.32.63.41.8-1.81.71.8-0.8-1.5-1.6-1.8-1.8-1.61.61.5-1.7-1.2
Condit. Reinf. active-inactive response ratio0.70.81.11.0-1.01.01.1-0.6-0.9-0.9-1.0-1.0-0.90.80.8-0.8-0.5
Condit. Reinf. active responses4.55.67.12.7-2.72.42.7-1.0-2.0-2.3-2.5-2.6-2.42.52.4-2.6-1.9
Condit. Reinf. inactive responses1.51.92.81.5-1.51.31.5-0.4-1.0-1.2-1.3-1.5-1.41.51.4-1.7-1.3
Incentive salience index mean1.82.23.11.6-1.61.41.8-0.5-1.2-1.4-1.5-1.7-1.41.61.4-1.7-1.2
Condit. Reinf. lever presses0.10.10.50.1-0.1-0.30.50.70.40.20.1-0.50.00.5-0.1-0.4-0.2
Condit. Reinf. active minus inactive responses0.60.81.51.2-1.21.01.1-0.1-0.7-0.8-1.1-1.0-1.10.51.0-0.60.0
Condit. Reinf. active-inactive response ratio2.12.43.71.7-1.71.91.3-1.3-1.8-1.8-1.9-1.2-1.81.01.7-1.3-0.8
Condit. Reinf. active responses0.10.20.40.6-0.60.30.70.5-0.1-0.2-0.4-0.6-0.40.20.3-0.20.2
Condit. Reinf. inactive responses0.81.01.6-0.90.9-1.1-0.61.31.11.11.10.61.2-0.7-1.21.00.9
Condit. Reinf. lever presses0.30.40.80.6-0.60.20.90.40.0-0.2-0.6-0.9-0.60.70.6-0.6-0.5
Condit. Reinf. lever reinforcers received0.20.20.60.6-0.60.30.80.60.0-0.2-0.5-0.7-0.40.40.4-0.30.1
Conditioned reinforcement - actives0.10.20.40.2-0.2-0.2-0.20.60.60.50.30.20.4-0.2-0.40.40.6
Conditioned reinforcement - inactives0.10.20.30.5-0.50.50.6-0.4-0.5-0.6-0.2-0.50.20.5-0.4-0.5-0.0
Conditioned locomotion0.10.10.30.6-0.60.20.10.40.30.20.0-0.10.10.0-0.2-0.10.0
Patch foraging indifference point 0 sec0.00.10.30.1-0.10.10.3-0.4-0.3-0.3-0.1-0.3-0.00.40.0-0.5-0.4
Patch foraging indifference point AUC0.10.20.30.3-0.30.10.40.20.0-0.1-0.5-0.5-0.50.50.6-0.5-0.5
Delay disc. indifference point, 0s delay0.10.10.60.1-0.1-0.1-0.10.20.20.20.20.10.4-0.3-0.30.40.8
Delay disc. indifference point, 16s delay1.31.54.5-0.80.8-1.5-0.62.11.81.71.30.60.9-0.8-0.60.91.3
Delay disc. indifference point, 2s delay0.60.71.2-0.80.8-0.7-0.80.30.50.60.90.81.1-0.8-1.10.90.9
Delay disc. indifference point, 24s delay4.55.17.3-2.62.6-2.4-2.71.11.82.12.32.72.0-2.6-1.92.32.1
Delay disc. indifference point, 4s delay0.30.31.2-0.40.4-0.5-0.50.20.40.40.40.50.3-0.6-0.30.71.1
Delay disc. indifference point, 8s delay0.91.02.2-1.11.1-0.8-1.10.30.40.61.11.11.2-1.1-0.81.11.5
Indifference point function ln k0.91.52.8-1.11.1-1.2-1.00.91.21.31.21.11.2-1.3-1.21.61.7
Indifference point function log k0.91.52.8-1.11.1-1.2-1.00.91.21.31.21.11.2-1.3-1.21.61.7
Patch foraging total patch changes 0 sec0.10.10.30.2-0.20.10.4-0.3-0.2-0.3-0.2-0.4-0.10.50.1-0.5-0.3
Patch foraging total patch changes 12 sec0.20.20.70.3-0.30.40.3-0.7-0.6-0.6-0.2-0.3-0.10.50.1-0.7-0.8
Patch foraging total patch changes 18 sec0.10.10.40.2-0.2-0.20.40.60.50.30.0-0.40.10.3-0.1-0.4-0.1
Patch foraging total patch changes 24 sec0.40.81.11.1-1.10.91.0-0.6-0.8-0.9-0.7-1.0-0.80.90.7-1.0-0.6
Patch foraging total patch changes 6 sec0.40.71.10.6-0.60.70.6-1.0-0.9-0.9-0.8-0.6-0.90.70.9-1.0-0.9
Patch foraging time to switch 0 sec0.30.61.0-1.01.0-0.9-0.90.50.80.80.90.80.8-0.7-0.80.60.3
Patch foraging water rate 0 sec1.22.64.52.1-2.11.72.1-0.8-1.5-1.7-1.4-2.0-1.11.81.0-1.5-0.5
Patch foraging water rate 12 sec0.20.51.51.2-1.20.61.00.6-0.0-0.2-0.5-0.9-0.30.30.2-0.20.9
Patch foraging water rate 18 sec0.60.92.21.5-1.50.81.30.4-0.1-0.3-1.0-1.2-1.00.80.9-0.60.2
Patch foraging water rate 24 sec1.62.35.22.3-2.31.52.20.4-0.7-1.0-1.4-2.1-1.31.51.0-1.3-0.4
Patch foraging water rate 6 sec0.30.42.20.9-0.90.30.50.40.10.10.2-0.30.4-0.2-0.70.31.5
Seeking ratio, delayed vs. immediate footshock1.31.62.11.5-1.51.31.4-0.7-1.0-1.2-1.4-1.4-1.31.31.5-1.2-0.9
Distance traveled before self-admin0.60.82.40.5-0.51.00.6-1.5-1.4-1.3-0.6-0.5-0.50.70.7-0.6-0.6
Distance traveled after self-admin0.70.92.40.8-0.80.51.2-0.3-0.6-0.8-0.6-1.2-0.71.50.8-1.1-1.2
Extensor digitorum longus weight0.20.81.51.1-1.10.31.20.90.50.2-1.0-1.2-1.10.71.1-0.7-0.2
Bone: elastic displacement1.31.52.31.2-1.21.40.9-1.4-1.4-1.3-1.5-0.8-1.40.81.4-1.1-0.8
Bone: elastic work6.38.215.13.0-3.03.71.9-3.9-3.8-3.5-3.2-1.6-2.81.62.7-2.3-1.5
Bone: endosteal estimation0.10.20.70.1-0.1-0.30.40.90.60.40.2-0.50.20.5-0.2-0.2-0.4
Bone: endosteal perimeter0.51.11.71.0-1.01.11.0-1.0-1.0-1.1-1.0-1.0-0.91.31.0-1.1-1.3
Epididymis fat weight0.93.15.52.3-2.31.82.3-0.8-1.3-1.5-1.8-2.2-1.61.91.5-1.6-0.6
Delta time in closed arm before/after self-admin0.30.31.5-0.20.2-0.70.41.20.90.60.4-0.40.40.3-0.30.00.3
Delta time in open arm before/after self-admin0.10.10.5-0.30.3-0.3-0.40.10.10.30.50.30.7-0.3-0.70.2-0.2
Diff in mean of infusions in LGA sessions0.20.20.7-0.20.20.3-0.1-0.8-0.6-0.60.20.10.60.4-0.6-0.1-0.5
Delay discount exponential model param2.12.43.61.6-1.61.61.5-1.1-1.3-1.5-1.7-1.5-1.51.61.3-1.6-1.9
Extinction: sum of active levers before priming0.70.82.0-0.60.6-0.4-1.30.10.40.80.81.30.5-1.4-0.81.01.0
Active lever presses in extinction session 62.12.14.5-1.01.0-0.2-1.8-1.3-0.50.11.51.91.8-1.9-1.91.52.1
Bone: final force5.18.214.83.8-3.83.72.8-2.5-2.9-2.9-3.2-2.5-2.91.82.7-2.1-0.5
Bone: final moment6.09.616.24.0-4.04.02.9-2.9-3.3-3.2-3.5-2.5-3.21.93.0-2.4-0.7
Food consumed during 24 hour testing period0.40.61.60.5-0.50.40.8-0.4-0.5-0.7-0.7-0.8-0.81.00.8-1.0-1.3
Glucose7.211.421.4-3.83.8-2.1-4.6-0.70.61.63.44.63.7-4.2-3.83.63.2
Heart weight0.81.32.71.4-1.41.60.7-1.3-1.4-1.2-1.3-0.5-1.30.21.2-0.7-0.2
Delay discount hyperbolic model param1.92.23.11.5-1.51.51.5-1.0-1.2-1.3-1.7-1.5-1.51.51.3-1.6-1.8
Intermittent access intake day 1-15 change0.61.33.21.6-1.61.80.5-1.6-1.4-1.4-0.0-0.50.41.0-0.4-1.0-0.9
Intermittent access intake escalation0.61.23.01.6-1.61.70.5-1.5-1.3-1.3-0.0-0.50.41.0-0.3-0.9-0.7
Intermittent access intake escalation 21.82.05.41.8-1.82.30.5-2.3-2.0-1.9-0.2-0.50.21.1-0.1-1.0-1.1
Intermitt. access day 1 inactive lever presses0.93.46.12.5-2.52.02.3-0.8-1.3-1.7-1.4-2.3-1.22.31.2-1.9-1.4
Intermitt. access day 15 inactive lever presses0.61.21.91.4-1.40.91.30.2-0.3-0.6-0.9-1.4-1.11.31.0-1.2-1.3
Intermitt. access escalation Index0.50.71.51.0-1.00.61.10.3-0.1-0.4-0.6-1.1-0.71.20.9-0.9-1.2
Intermittent access day 1 total infusions0.20.31.20.6-0.60.40.3-0.1-0.2-0.1-0.7-0.2-1.00.11.1-0.4-0.1
Intermittent access day 15 total infusions0.71.12.91.7-1.71.50.7-0.8-0.8-0.9-0.7-0.7-0.70.90.8-1.0-0.8
Intermittent access terminal intake (last 3 days)0.91.22.41.6-1.61.50.8-1.0-1.1-1.1-0.7-0.8-0.81.10.8-1.2-1.1
Intermittent access total infusions0.40.41.11.1-1.10.90.5-0.4-0.4-0.5-0.5-0.5-0.70.50.7-0.7-0.4
Intermittent access day 1 locomotion0.10.10.50.4-0.40.10.00.30.20.20.20.00.4-0.2-0.30.10.7
Intermittent access day 15 total locomotion0.40.71.91.4-1.41.30.6-0.8-0.8-0.8-0.6-0.5-0.20.6-0.1-0.8-0.2
Intermittent access total locomotion0.20.31.01.0-1.00.80.4-0.4-0.4-0.5-0.1-0.30.30.3-0.3-0.40.2
Intermittent access standard deviation0.61.22.60.4-0.40.8-1.3-1.1-0.4-0.11.61.41.6-1.1-1.60.91.2
Left kidney weight0.10.31.10.4-0.40.6-0.2-0.9-0.5-0.3-0.10.40.2-0.8-0.30.21.1
Right kidney weight0.10.32.10.3-0.30.4-0.3-0.5-0.30.00.10.50.3-1.0-0.50.41.4
Cocaine induced anxiety0.91.36.90.3-0.31.4-0.3-2.6-2.1-1.60.20.50.7-0.4-0.80.50.8
Post-drug Anxiety1.31.43.2-0.80.80.3-1.1-1.8-1.2-0.71.01.31.4-1.1-1.71.01.4
Baseline Anxiety1.11.22.3-1.51.5-1.5-1.01.21.31.21.11.00.7-0.9-1.00.60.5
Tail length3.112.315.83.6-3.63.63.8-2.8-3.3-3.7-3.5-3.7-3.14.03.1-3.9-3.2
Length with tail1.14.810.52.3-2.32.81.9-3.2-3.1-3.0-1.8-1.7-1.21.91.1-2.0-0.8
Length without tail0.41.14.70.2-0.21.0-0.6-2.2-1.8-1.2-0.00.80.5-0.9-0.70.71.6
Times rat made contact with spout2.02.28.90.4-0.41.20.5-1.9-1.7-1.7-1.2-0.7-1.41.41.4-1.9-3.0
Lifetime Intake0.10.10.60.8-0.80.60.1-0.1-0.1-0.1-0.0-0.1-0.20.10.2-0.30.0
Liver weight, left1.21.93.6-1.41.4-1.2-1.40.00.71.01.41.41.7-1.4-1.81.61.9
Liver weight, right1.52.74.41.9-1.91.62.1-1.2-1.3-1.5-1.7-2.0-1.51.91.4-1.6-1.2
Locomotor activity0.71.11.6-1.11.1-1.0-1.10.60.91.01.31.11.1-1.0-1.11.00.8
Locomotor testing distance1.42.53.5-1.61.6-1.9-1.31.51.81.91.71.31.4-1.4-1.41.71.3
Locomotor testing rearing0.40.71.4-0.90.9-1.1-0.51.11.21.01.00.41.0-0.3-0.90.60.2
Locomotion in novel chamber0.40.51.2-0.70.7-0.8-0.31.10.90.80.60.30.6-0.4-0.80.61.0
Locomotion in novel chamber post-restriction3.04.96.62.1-2.12.22.3-1.7-2.1-2.4-2.1-2.3-2.02.62.0-2.5-2.3
Fecal boli incidents, locomotor time 10.20.31.0-0.50.5-0.9-0.40.91.00.90.30.30.3-0.4-0.20.2-0.3
Change in fecal boli incidents, locomotor task2.02.03.7-1.61.6-0.7-1.8-0.50.10.41.91.81.9-1.4-1.81.21.2
Time >=10cm from walls, locomotor time 11.11.22.31.1-1.10.51.50.5-0.1-0.5-0.7-1.5-1.31.51.1-1.5-1.2
Bouts of movement, locomotor time 11.21.32.2-1.21.2-1.2-1.50.61.11.31.01.50.6-1.5-0.61.40.9
Total resting periods, locomotor time 11.51.62.9-1.41.4-1.4-1.70.41.11.31.11.70.7-1.6-0.71.50.9
Rest time, locomotor task time 10.40.51.1-0.90.9-0.6-1.1-0.60.10.30.61.00.5-0.8-0.20.8-0.1
Distance moved, locomotor task time 10.20.40.70.8-0.80.90.80.0-0.4-0.60.1-0.70.40.7-0.3-0.60.5
Vertical activity count, locomotor time 10.30.81.81.2-1.21.01.30.2-0.5-0.7-0.4-1.3-0.21.10.1-1.0-0.1
Time >=10cm from walls, locomotor time 20.20.31.30.6-0.60.60.3-0.1-0.2-0.1-0.8-0.3-0.90.01.1-0.6-0.2
Bouts of movement, locomotor time 20.81.32.4-1.11.1-1.2-0.91.01.11.11.20.91.2-1.0-1.11.31.5
Total resting periods, locomotor time 20.40.71.3-0.80.8-1.0-0.41.11.11.00.80.40.8-0.6-0.60.91.1
Rest time, locomotor task time 20.10.10.3-0.40.4-0.4-0.10.00.20.1-0.00.1-0.30.20.40.3-0.5
Distance moved, locomotor task time 20.10.11.10.4-0.40.40.00.10.00.10.10.10.1-0.30.0-0.01.0
Vertical activity count, locomotor time 20.10.20.50.6-0.60.30.40.60.30.30.1-0.30.2-0.2-0.1-0.10.7
Light reinforcement 10.71.83.81.3-1.30.81.90.5-0.3-0.7-1.3-2.0-1.31.91.2-1.4-1.6
Light reinforcement 21.42.23.61.8-1.81.41.9-0.4-1.0-1.2-1.5-1.9-1.41.81.3-1.5-1.2
Bone: marrow area0.10.20.70.1-0.1-0.30.40.90.60.40.2-0.50.20.5-0.2-0.2-0.3
Bone: maximum diameter1.01.93.61.9-1.91.81.3-1.4-1.5-1.4-1.4-1.1-1.30.81.2-0.8-0.0
Bone: maximum force5.08.816.14.0-4.03.83.0-2.3-2.9-2.9-3.4-2.7-3.01.92.9-2.3-0.6
Bone: maximum moment5.710.017.14.1-4.14.13.0-2.7-3.3-3.2-3.6-2.7-3.32.03.1-2.5-0.8
Mean time between licks in bursts0.92.22.8-1.51.5-1.7-1.31.11.51.61.61.31.6-1.4-1.61.51.5
Mean num. licks in bursts0.30.51.80.0-0.00.7-0.1-1.4-1.1-1.0-0.50.0-0.30.50.3-0.7-1.2
Cd content in liver0.30.31.2-0.20.2-0.70.11.11.10.90.5-0.10.5-0.0-0.50.30.3
Co content in liver0.10.10.6-0.00.0-0.10.0-0.4-0.0-0.10.2-0.10.00.3-0.1-0.4-0.8
Cu content in liver0.80.93.40.7-0.71.10.4-1.9-1.4-1.3-0.7-0.3-0.60.70.6-0.8-1.0
Fe content in liver0.50.61.2-0.80.8-1.1-0.50.81.01.01.00.50.9-0.5-0.90.70.6
K content in liver1.21.23.10.9-0.90.31.70.5-0.1-0.5-0.7-1.7-0.81.80.7-1.3-1.4
Mg content in liver0.90.92.40.6-0.6-0.31.41.30.80.3-0.3-1.5-0.41.40.4-1.1-1.2
Mn content in liver0.10.10.20.3-0.30.20.30.1-0.1-0.1-0.4-0.3-0.50.10.5-0.10.1
Na content in liver0.10.20.4-0.30.3-0.50.20.60.60.40.5-0.20.50.2-0.50.10.0
Rb content in liver2.42.84.41.9-1.91.32.10.0-0.6-1.0-1.9-2.1-1.91.91.9-1.7-1.8
Se content in liver0.40.51.90.5-0.50.30.8-0.0-0.3-0.5-0.5-0.8-0.71.00.7-1.0-1.4
Sr content in liver0.40.41.0-0.70.7-0.0-1.0-1.0-0.4-0.20.31.00.3-0.7-0.20.40.4
Zn content in liver1.61.83.11.4-1.41.11.6-0.8-0.9-1.2-1.1-1.6-1.01.81.0-1.7-1.7
Bone: minimum diameter2.64.86.82.6-2.62.62.0-2.3-2.4-2.3-2.3-1.8-2.21.82.2-1.9-1.2
Time in familiar zone, hab. session 10.00.00.10.0-0.00.3-0.2-0.3-0.4-0.30.10.30.1-0.3-0.20.10.1
Time in novel zone, hab. session 10.00.00.10.1-0.1-0.10.20.20.20.2-0.2-0.2-0.10.20.2-0.1-0.1
Total zone transitions, hab. session 10.20.30.8-0.20.2-0.5-0.40.90.70.80.30.40.2-0.7-0.20.70.8
Total locomotion distance, hab. session 10.10.20.40.5-0.50.10.50.50.20.2-0.6-0.5-0.60.10.6-0.10.1
Locomotion velocity, hab. session 10.10.20.40.4-0.40.10.50.50.30.2-0.6-0.5-0.70.20.6-0.10.0
Time in familiar zone, hab. session 20.20.30.5-0.40.4-0.4-0.40.50.60.60.70.40.7-0.4-0.70.30.4
Time in novel zone, hab. session 20.00.00.1-0.10.1-0.2-0.00.20.10.1-0.20.1-0.1-0.20.10.30.4
Total zone transitions, hab. session 20.40.63.00.3-0.3-0.60.71.71.20.9-0.5-0.7-0.70.10.70.00.1
Total locomotion distance, hab. session 20.81.12.31.1-1.10.21.51.20.60.2-1.2-1.5-1.31.01.3-0.7-0.5
Locomotion velocity, hab. session 21.11.42.91.3-1.30.51.71.00.3-0.1-1.4-1.7-1.51.21.5-0.9-0.7
Novel to familiar place preference ratio2.42.64.91.6-1.62.01.1-2.2-2.2-2.1-1.7-0.9-1.51.01.4-1.4-1.0
Novelty place preference2.32.54.91.5-1.52.01.0-2.1-2.2-2.1-1.6-0.9-1.41.01.4-1.3-1.0
Time in novel zone, NPP test1.92.03.81.4-1.41.81.0-1.9-2.0-1.8-1.5-0.9-1.30.91.3-1.2-0.9
Total zone transitions, NPP test0.60.95.0-0.10.1-1.10.52.21.71.40.1-0.6-0.20.10.20.30.3
Total locomotion distance, NPP test0.60.93.50.6-0.6-0.51.31.91.20.7-0.6-1.3-0.80.80.8-0.4-0.3
Locomotion velocity, NPP test0.60.81.90.7-0.7-0.21.31.40.80.4-0.8-1.3-1.00.91.0-0.5-0.5
Intraocular pressure1.01.42.11.4-1.41.21.5-0.3-0.8-1.1-1.2-1.5-1.11.51.1-1.3-1.0
Delta distance traveled before/after self-admin0.20.21.1-0.20.2-0.7-0.01.00.90.70.5-0.10.30.2-0.40.1-0.1
Delta ambulatory time before/after self-admin0.70.92.7-0.80.8-1.4-0.41.71.51.30.90.30.6-0.1-0.70.50.0
Parametrial fat weight0.61.42.21.1-1.10.81.5-0.4-0.6-0.9-1.2-1.5-1.21.51.1-1.5-1.5
Pavlov. Cond. lever latency0.81.03.7-0.70.7-1.2-0.11.91.71.40.70.10.7-0.4-0.70.80.7
Pavlov. Cond. magazine entry latency1.72.25.71.3-1.31.90.8-2.4-2.3-2.2-1.2-0.7-0.91.00.8-1.4-0.7
Pavlov. Cond. change in total contacts0.40.42.60.1-0.10.7-0.4-1.6-1.2-0.9-0.00.50.1-0.3-0.2-0.10.2
Pavlov. Cond. index score2.43.05.81.7-1.72.11.3-2.4-2.4-2.3-1.6-1.1-1.41.41.4-1.7-1.2
Pavlov. Cond. latency score1.92.45.51.4-1.41.90.9-2.3-2.3-2.1-1.4-0.8-1.21.11.2-1.5-1.1
Pavlov. Cond. lever contacts0.50.61.80.7-0.70.90.4-1.3-1.2-1.1-0.7-0.3-0.60.50.6-0.8-0.6
Pavlov. Cond. magazine entry number1.92.48.4-1.21.2-2.0-0.52.92.62.31.20.40.9-0.8-0.91.30.8
Pavlov. Cond. intertrial magazine entries0.50.61.30.9-0.90.41.10.60.1-0.2-0.8-1.1-0.91.00.9-0.8-0.8
Pavlov. Cond. lever-magazine prob. diff.2.32.85.51.7-1.72.01.2-2.3-2.3-2.2-1.5-1.1-1.31.31.2-1.6-1.0
Pavlov. Cond. response bias1.41.76.01.1-1.11.70.5-2.5-2.2-2.0-1.0-0.3-0.70.60.6-1.1-0.6
Pavlov. Cond. lever latency1.11.52.7-1.21.2-0.7-1.6-0.30.30.61.21.61.3-1.5-1.31.41.6
Pavlov. Cond. magazine entry latency1.41.73.7-1.21.2-1.8-0.71.81.91.81.30.61.2-0.8-1.21.10.7
Pavlov. Cond. change in total contacts0.10.21.1-0.30.3-0.70.11.00.80.60.4-0.20.30.1-0.40.1-0.0
Pavlov. Cond. index score0.10.20.8-0.20.2-0.60.20.90.70.50.2-0.30.10.2-0.1-0.1-0.3
Pavlov. Cond. latency score0.20.21.0-0.10.1-0.60.31.00.80.60.1-0.40.00.3-0.1-0.1-0.4
Pavlov. Cond. lever contacts0.81.22.21.0-1.00.51.40.4-0.2-0.5-1.1-1.5-1.11.41.1-1.2-1.5
Pavlov. Cond. magazine entry number1.11.32.51.1-1.11.60.5-1.5-1.6-1.4-1.3-0.5-1.20.61.2-0.9-0.7
Pavlov. Cond. intertrial magazine entries1.72.63.61.9-1.91.71.7-0.6-1.3-1.4-1.8-1.7-1.91.51.8-1.5-1.2
Pavlov. Cond. lever-magazine prob. diff.0.20.31.0-0.40.4-0.8-0.01.00.90.70.5-0.10.3-0.0-0.40.1-0.1
Pavlov. Cond. response bias0.10.20.70.2-0.2-0.30.60.80.40.2-0.1-0.6-0.10.50.1-0.3-0.4
Time in closed arm before self-admin0.20.30.9-0.50.5-0.1-0.9-0.6-0.20.10.00.9-0.1-0.9-0.20.70.5
Time in closed arm after self-admin0.90.91.9-1.31.3-0.7-1.1-0.20.20.31.01.11.1-0.9-1.41.10.9
Time in open arm before self-admin0.40.51.30.5-0.5-0.10.71.00.70.4-0.6-0.8-0.90.51.1-0.6-0.4
Time in open arm after self-admin0.10.10.50.3-0.3-0.10.20.70.50.40.1-0.20.30.0-0.0-0.2-0.0
Bone: periosteal estimation1.32.85.32.3-2.32.11.8-1.3-1.5-1.6-1.8-1.6-1.61.21.6-1.3-0.3
Bone: periosteal perimeter2.64.69.12.4-2.42.91.4-3.0-2.9-2.6-2.1-1.2-1.91.21.8-1.5-0.7
Bone: post-yield work0.10.10.30.3-0.30.00.20.60.30.30.1-0.20.1-0.1-0.20.10.5
Progressive ratio test 1 active lever presses0.40.41.41.2-1.21.00.6-0.4-0.5-0.5-0.1-0.50.30.6-0.1-0.7-0.3
Progressive ratio test 1 breakpoint0.40.51.61.3-1.31.00.7-0.5-0.6-0.6-0.1-0.60.20.7-0.0-0.8-0.4
Progressive ratio test 1 inactive lever presses2.63.87.02.6-2.62.12.3-0.6-1.2-1.5-1.7-2.3-1.62.21.7-2.1-1.8
Progressive ratio test 2 active lever presses0.30.41.21.1-1.10.80.7-0.2-0.4-0.5-0.3-0.70.00.70.1-0.7-0.4
Progressive ratio test 2 breakpoint0.40.41.31.1-1.10.90.7-0.3-0.4-0.6-0.3-0.70.10.70.0-0.7-0.3
Progressive ratio test 2 inactive lever presses0.30.41.31.1-1.11.10.4-0.7-0.7-0.7-0.0-0.30.20.3-0.2-0.40.0
Incentive Sensitization - Responses0.30.50.80.8-0.80.50.8-0.2-0.4-0.6-0.7-0.8-0.50.90.4-0.8-0.9
Incentive Sensitization - Breakpoint0.30.40.70.7-0.70.50.7-0.2-0.4-0.6-0.6-0.7-0.30.80.3-0.7-0.8
Sum of active levers in priming session hrs 5-60.60.52.60.4-0.41.10.0-1.6-1.4-1.20.10.10.10.2-0.3-0.4-0.1
Progressive ratio0.60.91.5-1.01.0-1.0-1.10.71.01.10.91.10.6-1.2-0.50.80.7
Food seeking constrained by brief footshock0.20.30.7-0.80.8-0.2-0.9-0.7-0.2-0.00.30.80.1-0.5-0.10.1-0.3
Seeking ratio, punishment vs. effort0.10.20.40.3-0.30.40.5-0.1-0.3-0.3-0.5-0.6-0.50.60.4-0.4-0.6
Retroperitoneal fat weight2.510.815.93.7-3.73.14.0-1.5-2.5-2.9-3.3-3.9-3.23.83.1-3.6-2.8
Reaction time number correct0.71.36.30.8-0.8-0.61.62.51.40.9-0.5-1.7-0.41.10.4-0.4-0.2
Reaction time mean minus median0.10.30.8-0.60.6-0.1-0.9-0.5-0.10.10.60.80.6-0.5-0.50.30.2
Reaction time mean minus median AUC0.00.00.1-0.10.10.0-0.3-0.1-0.1-0.00.00.30.0-0.10.10.1-0.0
Reaction time num false alarms0.10.20.4-0.70.7-0.5-0.50.30.40.50.30.50.2-0.4-0.30.2-0.3
Reaction time num false alarms AUC0.30.50.9-0.90.9-0.9-0.70.80.90.90.60.70.4-0.6-0.40.6-0.0
Reaction time trials correct on left0.71.36.30.8-0.8-0.61.62.51.40.9-0.5-1.7-0.41.10.4-0.4-0.2
Reaction time trials on left0.71.36.50.8-0.8-0.61.62.51.50.9-0.5-1.7-0.41.10.4-0.4-0.2
Reaction time mean0.20.40.70.6-0.60.70.5-0.2-0.4-0.4-0.6-0.5-0.70.50.7-0.7-0.8
Reaction time mean AUC0.20.40.80.7-0.70.50.60.2-0.0-0.1-0.7-0.6-0.80.50.9-0.7-0.7
Median of all reaction times0.40.50.80.8-0.80.80.80.0-0.3-0.4-0.8-0.8-0.80.60.8-0.8-0.9
Reaction time omissions0.10.10.20.4-0.40.20.40.10.1-0.0-0.2-0.4-0.30.40.4-0.5-0.4
Reaction time false alarm rate0.50.82.2-1.21.2-0.5-1.5-0.60.10.30.71.40.6-1.1-0.50.6-0.0
Reaction time premature initiation rate1.01.41.9-1.41.4-1.4-1.20.91.11.21.31.21.2-1.1-1.21.10.8
Reaction time premature initiations0.61.14.2-0.70.7-1.5-0.12.11.71.40.80.10.7-0.3-0.70.70.5
Std. dev. reaction times0.10.20.5-0.50.5-0.5-0.70.50.60.60.50.60.3-0.5-0.20.30.1
Reaction time trials completed0.71.36.50.8-0.8-0.61.62.51.50.9-0.5-1.7-0.41.10.4-0.4-0.2
Reaction time trials AUC0.71.46.30.9-0.9-0.51.72.51.40.9-0.5-1.7-0.51.10.5-0.4-0.3
Run reversals in cocaine runway, females0.40.41.8-0.50.5-0.9-0.21.31.11.00.60.10.1-0.3-0.40.3-0.1
Run reversals in cocaine runway, males1.11.13.30.6-0.61.20.6-1.8-1.7-1.6-1.0-0.6-0.61.00.6-0.8-0.8
Latency to leave start box in cocaine runway0.30.30.8-0.50.5-0.9-0.30.80.90.80.50.20.3-0.3-0.10.4-0.2
Latency to leave start box in cocaine runway, F0.50.62.90.0-0.0-0.80.31.71.51.2-0.0-0.4-0.40.00.50.0-0.3
Latency to leave start box in cocaine runway, M0.20.20.4-0.60.6-0.3-0.4-0.6-0.4-0.30.50.40.6-0.2-0.60.30.0
Std. dev. time between licks in bursts0.71.02.71.1-1.1-0.01.61.50.80.3-0.6-1.6-0.71.10.7-0.6-0.2
Total sessions with >9 infusions0.30.30.8-0.10.1-0.3-0.70.40.60.70.90.80.5-0.8-0.40.30.8
Short access day 1 total inactive lever presses0.20.20.90.1-0.1-0.40.30.80.60.50.2-0.20.3-0.2-0.40.20.9
Short access day 10 total inactive lever presses1.23.05.91.5-1.51.52.4-1.0-1.6-1.9-1.6-2.3-1.52.21.3-1.9-1.4
Short access day 1 total infusions1.31.82.6-1.01.0-1.2-1.41.11.41.61.61.41.1-1.6-1.21.31.5
Short access day 10 total infusions1.11.42.41.4-1.41.50.8-1.3-1.3-1.3-0.7-0.8-0.81.10.7-1.4-1.3
Short access total infusions0.10.10.30.2-0.20.2-0.30.00.10.20.60.40.3-0.3-0.30.00.3
Short access day 1 locomotion0.40.41.1-0.10.10.1-0.9-0.20.10.40.91.00.6-1.0-0.80.61.0
Short access day 10 total locomotion0.20.41.0-0.30.30.3-0.9-1.0-0.5-0.20.70.90.8-0.7-0.90.40.5
Short access total locomotion0.40.40.80.5-0.50.7-0.7-0.8-0.4-0.20.70.80.9-0.7-0.90.30.8
One hour access (0.3 mA shock)0.50.61.91.4-1.40.90.7-0.1-0.3-0.4-0.7-0.8-0.40.80.5-0.8-0.8
Compulsive drug intake0.70.81.80.9-0.90.41.30.4-0.1-0.4-1.1-1.4-1.01.21.0-0.8-0.9
One hour access (shock baseline)0.10.10.50.7-0.70.40.20.10.0-0.0-0.2-0.2-0.30.30.4-0.4-0.5
Social response proportion0.50.51.1-0.40.4-0.6-0.30.80.80.71.00.41.0-0.6-1.10.51.0
Social responses0.30.41.2-0.40.4-0.7-0.30.60.80.80.60.40.7-0.6-0.70.61.1
Social time0.10.20.70.1-0.1-0.2-0.10.50.50.60.30.20.3-0.6-0.40.50.8
Soleus weight1.64.87.32.3-2.32.22.1-1.4-1.8-2.0-2.5-2.1-2.62.12.7-2.2-2.2
Bone: stiffness0.61.02.91.7-1.71.41.1-0.3-0.7-0.6-1.0-0.8-0.80.10.7-0.11.1
Tibialis anterior weight0.10.30.70.5-0.50.20.50.40.30.1-0.6-0.6-0.80.40.8-0.5-0.6
Time to tail flick, vehicle, before self-admin0.10.10.3-0.20.2-0.3-0.40.40.50.5-0.00.4-0.2-0.4-0.10.1-0.1
Time to tail flick, vehicle, after self-admin1.82.43.7-1.51.5-1.8-1.41.41.71.81.21.41.2-1.7-1.21.91.5
Time to tail flick, test, before self-admin0.10.10.3-0.60.6-0.4-0.3-0.00.10.10.40.30.5-0.2-0.50.20.5
Time to tail flick, test, after self-admin1.71.83.8-1.41.4-1.1-1.40.00.50.71.61.41.6-1.3-1.91.41.6
Delta time to tail flick, vehicle, before/after SA0.10.10.5-0.10.1-0.50.20.70.60.50.1-0.20.30.00.20.40.1
Delta time to tail flick, test, before/after SA0.80.81.5-0.70.7-0.4-1.1-0.20.10.50.91.20.8-1.2-1.11.11.2
Tibia length8.623.836.85.6-5.66.14.0-5.1-5.7-5.5-5.6-3.7-5.33.35.1-3.9-2.5
Ambulatory time before self-admin1.42.14.01.4-1.41.81.2-1.9-2.0-1.9-1.3-1.1-1.21.21.2-1.3-0.9
Ambulatory time after self-admin0.40.41.00.7-0.70.50.8-0.3-0.5-0.6-0.4-0.8-0.61.00.4-0.9-0.7
Bone: tissue strength2.02.03.71.9-1.91.51.7-0.6-0.9-1.0-1.7-1.6-1.51.11.4-1.3-0.5
Total heroin consumption0.50.51.5-0.20.20.4-0.8-1.0-0.6-0.20.61.00.5-1.0-0.40.91.2
Bone: trabecular number0.10.10.50.0-0.00.10.2-0.1-0.2-0.2-0.3-0.2-0.40.30.3-0.4-0.7
Bone: trabecular spacing0.50.72.10.8-0.8-0.21.31.50.90.5-0.4-1.3-0.40.90.4-0.30.0
Bone: trabecular thickness0.81.04.20.5-0.51.3-0.0-2.0-1.7-1.4-0.60.1-0.60.40.6-0.8-1.1
Bone: trabecular tissue density0.81.21.5-1.01.0-1.1-1.00.91.21.21.21.01.1-1.1-1.11.11.0
Water consumed over 24 hours0.20.20.6-0.60.6-0.1-0.6-0.8-0.4-0.20.10.60.0-0.20.0-0.1-0.7
Number of responses in last shaping day0.20.31.20.4-0.40.1-0.30.20.30.40.50.40.2-0.7-0.50.61.1