Hub : Genes

Crtc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Crtc1	0.04	0.03	8.8e-03	0.04	0.04	0	0.03	6.6e-03	1.2e-02	2.3e-01	1.8e-02
2	Brain	gene expression	Crtc1	0.04	0.03	2.5e-05	0.06	0.06	0.06	0.06	2.2e-06	5.3e-06	2.0e-06	3.0e-06
3	PL	gene expression	Crtc1	0.03	0.02	8.4e-04	0.03	0.02	0	0.02	9.3e-04	2.8e-03	2.4e-01	3.5e-03
4	RMTg	isoform ratio	NM_001047115.2	0.26	0.13	3.3e-04	0.18	0.15	0.13	0.13	1.3e-05	7.4e-05	2.1e-04	2.1e-04
5	Adipose	mRNA stability	Crtc1	0.11	0.07	3.7e-04	0.03	0	0	0.01	3.8e-04	2.1e-01	2.0e-01	1.2e-02
6	NAcc	gene expression	Crtc1	0.03	0.02	1.1e-03	0.03	0.02	0.02	0.02	3.3e-05	9.6e-04	5.9e-04	2.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	2.4	4.2	11.7	-2.7	-0.6	-1.2	1.7	-3.4	1.3
Area under the delay curve	0.0	0.0	0.1	0.2	0.1	-0.0	-0.4	0.1	-0.0
BMI with tail	1.2	4.0	7.1	-2.7	-2.3	-1.9	1.1	-1.2	-2.4
BMI without tail	2.3	6.9	10.2	-2.9	-3.2	-2.8	1.6	-1.8	-3.0
Body weight	3.9	16.9	28.1	-5.3	-4.6	-4.2	3.4	-3.6	-3.1
Weight adjusted by age	1.6	2.4	4.5	-2.1	-1.8	-1.6	0.8	-1.4	-1.2
Bone surface	1.0	1.9	5.2	-2.2	-0.3	-0.4	0.9	-2.3	0.5
Bone volume	1.9	3.5	8.9	-2.8	-0.9	-1.1	1.5	-3.0	0.3
Breakpoint value in progressive ratio session	0.1	0.2	0.4	-0.1	-0.1	0.3	-0.4	0.6	-0.6
Number of licking bursts	0.1	0.2	0.6	0.8	0.4	0.3	-0.3	0.3	0.5
Context. condit. distance diff. score	0.4	0.5	1.5	1.0	0.1	-0.4	0.6	0.1	1.2
Locomotion velocity, session 1	1.1	1.2	2.2	0.8	0.7	1.1	-1.4	1.5	-0.9
Locomotion distance, session 1	1.4	1.8	3.5	1.1	1.7	1.9	-1.4	0.5	0.8
Locomotion velocity, session 2	0.9	1.0	2.5	-0.2	-1.3	-1.0	0.0	0.9	-1.6
Locomotion distance, session 2	1.6	2.2	4.2	1.3	1.9	2.0	-1.5	0.8	0.9
Locomotion velocity, session 3	1.3	1.5	5.0	2.2	0.7	0.4	-0.4	1.8	0.3
Locomotion distance, session 3	0.6	0.6	1.5	0.3	1.0	0.8	-0.1	-0.7	1.2
Stereotopy head waving bouts, day 3	1.7	2.0	6.0	2.5	0.8	0.3	0.4	1.1	1.9
Stereotopy head waving duration, day 3	0.9	1.1	3.4	1.9	0.2	-0.2	0.5	1.0	1.2
Locomotion velocity, session 7	1.1	1.3	1.7	1.3	1.2	1.3	-1.1	1.3	0.3
Locomotion distance, session 7	0.8	1.0	2.1	0.6	1.4	1.4	-0.9	0.6	0.6
Stereotopy head waving bouts, day 7	0.2	0.3	0.8	0.5	-0.1	-0.4	0.6	-0.1	0.9
Stereotopy head waving duration, day 7	0.4	0.5	1.1	0.6	-0.8	-1.0	0.7	0.5	0.2
Locomotion velocity, session 8	2.4	2.9	6.9	2.6	1.3	1.2	-1.2	2.3	0.5
Locomotion distance, session 8	0.7	1.0	1.5	1.0	1.2	1.2	-0.9	0.4	1.0
Degree of sensitization distance	0.4	0.4	1.3	0.4	0.3	0.5	-0.6	1.1	-0.3
Degree of sensitization stereotypy	0.3	0.3	0.5	-0.5	-0.4	-0.5	0.7	-0.7	0.5
Conditioned locomotion	0.1	0.1	0.4	0.2	0.1	0.1	0.6	-0.0	0.6
Cocaine response after cond. corrected	0.6	0.8	1.7	0.6	-0.4	-1.0	1.2	0.0	1.3
Cocaine response after cond. not corrected	0.5	0.5	1.5	1.2	0.1	-0.3	0.4	0.8	0.9
Cocaine response before conditioning	1.7	2.0	4.3	0.9	1.0	1.5	-2.1	1.5	-1.2
Saline control response	0.1	0.1	0.4	0.1	0.4	0.4	-0.6	-0.1	0.2
Bone: connectivity density	1.9	2.9	9.0	-2.6	-0.4	-0.7	1.0	-3.0	0.5
Bone: cortical apparent density	0.4	0.5	1.9	-0.4	0.4	0.1	-1.4	0.1	-0.9
Bone: cortical area	5.3	8.2	14.5	-3.8	-2.8	-2.8	3.1	-2.9	-1.0
Bone: cortical porosity	0.3	0.4	0.9	-0.2	0.5	1.0	-0.7	0.3	-0.7
Bone: cortical porosity	0.3	0.3	0.8	-0.2	0.5	0.9	-0.5	0.1	-0.5
Bone: cortical thickness	3.9	6.5	10.1	-3.2	-2.1	-2.4	3.2	-3.0	0.1
Bone: cortical thickness	3.8	4.5	8.7	-1.5	-0.9	-1.6	2.9	-2.9	2.1
Bone: cortical tissue density	0.4	0.5	2.2	-0.2	0.5	0.2	-1.5	0.2	-0.8
Condit. Reinf. active minus inactive responses	1.0	1.1	2.8	-0.8	-0.3	-0.4	1.3	-1.7	1.0
Condit. Reinf. active-inactive response ratio	1.8	1.9	5.5	-1.2	-0.2	-0.4	1.4	-2.3	1.4
Condit. Reinf. active responses	0.7	0.8	2.0	-0.8	-0.6	-0.5	1.2	-1.4	0.6
Condit. Reinf. inactive responses	0.3	0.3	1.1	-0.4	-0.7	-0.4	0.1	0.1	-1.0
Incentive salience index mean	0.4	0.5	1.2	-0.8	-0.5	-0.4	0.8	-1.1	0.2
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.5	-0.6	-0.3	0.1	-0.2	-0.7
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	0.2	0.6	0.7	-0.5	-0.1	0.2
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.7	-0.5	-0.4	-0.5	0.8	-0.4	0.0
Condit. Reinf. active responses	1.0	1.4	2.3	1.2	1.2	1.4	-1.5	1.1	-0.1
Condit. Reinf. inactive responses	2.8	3.6	6.1	2.1	1.6	1.8	-2.5	2.3	-0.6
Condit. Reinf. lever presses	0.5	0.7	2.0	0.6	-0.4	-0.1	-0.5	1.2	-1.4
Condit. Reinf. lever reinforcers received	0.4	0.6	1.0	0.8	0.6	0.7	-1.0	0.9	-0.6
Conditioned reinforcement - actives	1.1	1.8	2.8	-1.7	-1.5	-1.4	1.3	-1.2	-0.9
Conditioned reinforcement - inactives	5.9	8.7	13.6	-2.8	-3.4	-3.2	3.7	-2.5	-1.3
Conditioned locomotion	1.0	1.3	2.4	-1.0	-1.5	-1.5	1.2	-0.7	-0.8
Patch foraging indifference point 0 sec	1.5	2.7	5.0	-1.3	-2.2	-2.2	1.3	0.4	-1.7
Patch foraging indifference point AUC	0.5	0.7	1.5	0.3	-0.2	-0.2	-1.0	1.2	-1.2
Delay disc. indifference point, 0s delay	2.4	2.6	4.0	2.0	1.7	1.5	-1.6	1.9	0.7
Delay disc. indifference point, 16s delay	0.5	0.6	1.4	0.8	0.7	0.6	-1.2	0.8	-0.2
Delay disc. indifference point, 2s delay	0.5	0.5	0.8	0.9	0.9	0.6	-0.6	0.7	0.7
Delay disc. indifference point, 24s delay	0.3	0.3	1.1	0.2	-0.5	-0.5	-0.2	0.4	-1.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.1	0.1	0.0	-0.5	0.2	-0.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	-0.1	-0.5	-0.7	0.2	0.2	-0.4
Indifference point function ln k	0.5	0.9	2.3	-1.2	-0.6	-0.3	1.1	-1.5	0.1
Indifference point function log k	0.5	0.9	2.3	-1.2	-0.6	-0.3	1.1	-1.5	0.1
Patch foraging total patch changes 0 sec	2.2	4.1	7.7	-1.7	-2.8	-2.7	1.7	0.1	-2.1
Patch foraging total patch changes 12 sec	0.9	1.1	2.1	0.1	-1.3	-1.4	0.4	1.2	-1.2
Patch foraging total patch changes 18 sec	0.6	1.0	4.4	0.8	-0.2	-0.2	-0.2	2.1	-0.8
Patch foraging total patch changes 24 sec	0.2	0.4	0.8	-0.4	-0.8	-0.8	0.9	0.4	-0.3
Patch foraging total patch changes 6 sec	1.3	2.0	3.7	0.0	-1.7	-1.9	0.3	1.5	-1.6
Patch foraging time to switch 0 sec	0.9	1.9	3.1	1.5	1.3	1.5	-1.8	1.4	0.3
Patch foraging water rate 0 sec	0.7	1.5	2.2	-1.5	-1.3	-1.4	1.1	-1.0	-0.9
Patch foraging water rate 12 sec	0.6	1.2	3.3	-1.7	-0.6	-0.4	0.6	-1.8	-0.2
Patch foraging water rate 18 sec	0.3	0.5	0.9	-0.9	0.6	0.8	-0.5	-0.9	-0.2
Patch foraging water rate 24 sec	1.0	1.4	4.3	-2.0	-0.1	0.0	0.4	-2.1	-0.1
Patch foraging water rate 6 sec	1.1	1.7	2.5	-1.6	-1.2	-1.2	1.5	-1.3	-0.7
Seeking ratio, delayed vs. immediate footshock	1.1	1.4	3.1	1.5	1.0	1.0	-1.7	1.0	-0.2
Distance traveled before self-admin	0.5	0.6	1.3	-0.3	-1.1	-1.0	0.2	0.5	-1.1
Distance traveled after self-admin	0.6	0.8	1.4	-0.8	-1.2	-0.9	0.4	-0.2	-1.2
Extensor digitorum longus weight	0.2	0.7	1.4	0.4	-1.0	-1.2	0.5	0.9	-0.9
Bone: elastic displacement	0.3	0.3	0.5	0.1	0.7	0.7	-0.6	-0.6	0.5
Bone: elastic work	1.3	1.7	2.7	-1.6	-1.4	-1.5	1.2	-1.4	-0.5
Bone: endosteal estimation	0.2	0.3	1.1	-0.5	-0.7	-0.2	-0.2	0.2	-1.1
Bone: endosteal perimeter	0.6	1.4	2.2	-1.3	-1.5	-0.9	1.4	-0.7	-1.0
Epididymis fat weight	1.0	3.5	9.1	-3.0	-1.5	-1.1	-0.3	-1.6	-2.4
Delta time in closed arm before/after self-admin	0.3	0.3	0.9	0.3	-0.4	-0.5	-0.4	1.0	-0.4
Delta time in open arm before/after self-admin	0.5	0.5	1.6	0.1	0.8	1.0	-1.3	-0.0	-0.0
Diff in mean of infusions in LGA sessions	1.4	1.7	4.3	-0.5	-1.5	-1.2	-0.4	1.2	-2.1
Delay discount exponential model param	0.0	0.0	0.1	0.0	0.1	0.3	-0.0	0.1	0.0
Extinction: sum of active levers before priming	0.6	0.7	2.0	-0.3	0.9	1.0	-1.4	-0.3	-0.0
Active lever presses in extinction session 6	0.3	0.3	1.0	0.6	0.4	0.4	-1.0	0.7	-0.1
Bone: final force	5.2	8.3	12.7	-3.4	-3.6	-3.3	2.7	-2.1	-1.6
Bone: final moment	4.9	7.9	12.2	-3.3	-3.5	-3.2	2.7	-2.0	-1.5
Food consumed during 24 hour testing period	0.3	0.4	1.0	0.0	0.9	1.0	-0.6	0.2	0.6
Glucose	1.0	1.6	3.6	-1.2	-1.5	-1.2	0.6	0.3	-1.9
Heart weight	1.6	2.5	6.0	-0.8	-1.0	-1.2	2.5	-2.2	1.0
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.1	0.1	0.3	-0.0	0.0	-0.1
Intermittent access intake day 1-15 change	0.7	1.3	3.9	-1.6	-0.3	-0.2	1.0	-2.0	0.3
Intermittent access intake escalation	0.6	1.3	4.3	-1.4	-0.1	-0.0	0.9	-2.1	0.6
Intermittent access intake escalation 2	1.2	1.4	3.5	-1.8	-0.7	-0.6	0.4	-1.9	-0.5
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.8	0.2	-0.5	-0.5	0.9	-0.6	-0.1
Intermitt. access day 15 inactive lever presses	0.2	0.3	1.0	0.8	0.0	0.3	1.0	-0.4	0.5
Intermitt. access escalation Index	0.4	0.5	0.9	0.9	0.8	0.9	-0.3	0.4	0.7
Intermittent access day 1 total infusions	0.6	1.0	2.2	0.1	-1.5	-1.3	0.9	0.8	-1.0
Intermittent access day 15 total infusions	0.6	0.9	1.7	-1.2	-0.8	-0.5	1.2	-1.3	0.1
Intermittent access terminal intake (last 3 days)	0.5	0.7	1.6	-1.3	-0.8	-0.5	1.0	-0.8	-0.2
Intermittent access total infusions	1.2	1.4	2.7	-1.2	-1.6	-1.4	1.2	-0.2	-0.8
Intermittent access day 1 locomotion	1.4	1.8	3.4	-1.1	-1.8	-1.8	0.9	0.2	-1.5
Intermittent access day 15 total locomotion	0.2	0.4	1.0	-1.0	-0.5	-0.5	0.6	-0.5	-0.2
Intermittent access total locomotion	1.7	2.0	3.3	-1.7	-1.8	-1.8	1.1	-0.5	-1.2
Intermittent access standard deviation	0.2	0.4	0.9	-1.0	-0.7	-0.5	0.5	-0.6	-0.5
Left kidney weight	0.4	1.6	3.6	-1.1	-1.5	-1.3	0.2	0.9	-1.9
Right kidney weight	1.0	4.7	11.0	-2.6	-2.5	-2.1	0.3	-0.0	-3.3
Cocaine induced anxiety	1.0	1.4	2.2	-0.3	-1.4	-1.5	0.6	1.4	-1.3
Post-drug Anxiety	0.4	0.4	1.8	0.4	-0.1	-0.1	-0.3	1.3	-0.5
Baseline Anxiety	1.9	2.2	4.1	1.3	2.0	2.0	-1.4	0.2	1.2
Tail length	0.6	2.5	3.8	-1.5	-1.9	-1.8	0.9	-1.3	-1.7
Length with tail	1.5	6.5	10.4	-3.2	-3.0	-2.8	2.0	-2.1	-1.9
Length without tail	1.4	4.7	9.0	-3.0	-2.1	-2.1	2.4	-2.1	-0.2
Times rat made contact with spout	0.1	0.2	0.6	-0.1	0.6	0.8	-0.1	0.1	0.3
Lifetime Intake	1.9	2.3	4.2	-1.5	-2.0	-1.8	1.8	-0.6	-0.9
Liver weight, left	0.4	0.6	1.5	-0.1	0.9	1.0	-1.2	0.3	0.0
Liver weight, right	1.5	2.6	5.4	-2.3	-1.6	-1.2	-0.4	-0.9	-2.3
Locomotor activity	0.2	0.4	0.9	-1.0	0.3	0.4	-0.6	-0.8	-0.1
Locomotor testing distance	0.3	0.5	1.1	-0.3	0.9	0.8	-0.5	-1.0	0.7
Locomotor testing rearing	0.3	0.6	1.6	-0.4	0.9	0.9	-1.3	-0.3	-0.1
Locomotion in novel chamber	0.2	0.3	0.9	-0.9	-0.1	-0.2	-0.4	-0.9	-0.2
Locomotion in novel chamber post-restriction	1.4	2.3	8.7	-1.8	0.5	0.5	0.5	-3.0	1.0
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	-0.4	0.6	0.3	-0.5	-0.1	-0.0
Change in fecal boli incidents, locomotor task	1.4	1.3	4.4	1.6	0.4	0.5	-0.7	2.1	-0.4
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.2	0.0	-0.1	-0.2	-0.8	0.9	-1.1
Bouts of movement, locomotor time 1	0.5	0.6	1.9	-0.1	0.3	0.9	-1.4	0.3	-0.9
Total resting periods, locomotor time 1	0.8	0.8	2.5	0.1	0.7	1.3	-1.6	0.2	-0.6
Rest time, locomotor task time 1	0.1	0.2	0.5	0.7	-0.2	0.1	-0.3	0.5	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.5	0.2	0.1	0.1	0.5	0.1
Vertical activity count, locomotor time 1	0.0	0.1	0.3	-0.2	0.1	0.1	-0.5	-0.2	-0.1
Time >=10cm from walls, locomotor time 2	0.4	0.6	1.3	0.7	1.2	0.7	-0.2	0.1	1.2
Bouts of movement, locomotor time 2	0.1	0.2	0.7	0.8	0.1	0.3	-0.3	0.3	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.4	0.7	-0.0	0.2	-0.1	0.4	0.2
Rest time, locomotor task time 2	0.3	0.4	1.0	-0.3	-1.0	-0.7	0.3	0.0	-0.8
Distance moved, locomotor task time 2	0.2	0.2	0.8	0.3	0.6	0.3	0.2	0.0	0.9
Vertical activity count, locomotor time 2	0.3	0.5	1.7	0.0	0.4	-0.1	0.7	-0.6	1.3
Light reinforcement 1	0.2	0.5	1.1	-0.2	-0.2	-0.3	-0.7	1.1	-1.0
Light reinforcement 2	0.7	1.1	3.4	0.4	-0.9	-1.2	-0.4	1.8	-1.0
Bone: marrow area	0.1	0.3	0.9	-0.4	-0.6	-0.1	-0.2	0.2	-1.0
Bone: maximum diameter	2.2	4.1	7.3	-2.2	-2.1	-2.0	2.7	-1.8	-0.5
Bone: maximum force	4.5	8.0	13.8	-3.7	-3.3	-3.0	2.6	-2.4	-1.6
Bone: maximum moment	4.0	7.0	12.0	-3.5	-3.1	-2.8	2.5	-2.3	-1.4
Mean time between licks in bursts	1.0	2.3	3.8	-1.8	-1.9	-1.6	1.0	-1.0	-1.5
Mean num. licks in bursts	0.3	0.4	1.2	-1.1	-0.0	0.1	0.6	-0.9	0.2
Cd content in liver	4.1	4.6	12.0	-2.3	-1.1	-1.3	2.5	-3.5	0.8
Co content in liver	0.0	0.0	0.2	-0.1	0.1	-0.1	0.0	-0.0	0.4
Cu content in liver	1.2	1.5	2.9	0.9	1.7	1.6	-0.3	0.2	1.6
Fe content in liver	0.5	0.7	1.2	1.1	0.9	0.9	-0.8	0.7	0.2
K content in liver	1.9	1.8	2.9	1.7	1.5	1.5	-0.9	1.2	1.2
Mg content in liver	0.2	0.2	0.5	0.4	0.4	0.3	0.2	0.1	0.7
Mn content in liver	0.0	0.1	0.1	0.1	-0.1	0.2	0.3	-0.2	0.3
Na content in liver	2.4	2.5	4.2	1.3	2.0	2.1	-1.9	1.1	0.7
Rb content in liver	2.3	2.7	7.6	-0.9	-1.4	-1.7	2.8	-1.3	1.0
Se content in liver	0.3	0.4	0.8	0.3	0.8	0.7	-0.0	-0.2	0.9
Sr content in liver	0.5	0.4	1.0	-0.2	0.3	0.5	-1.0	-0.8	-0.6
Zn content in liver	0.1	0.1	0.4	-0.2	0.1	0.3	-0.3	0.2	-0.6
Bone: minimum diameter	1.8	3.3	6.7	-2.6	-1.9	-1.6	1.2	-1.4	-1.9
Time in familiar zone, hab. session 1	0.5	0.5	1.0	-0.9	-0.5	-0.3	-0.4	-0.6	-1.0
Time in novel zone, hab. session 1	0.4	0.4	1.2	0.3	0.2	-0.1	1.0	-0.5	1.1
Total zone transitions, hab. session 1	0.5	0.6	1.8	0.0	0.9	1.1	-1.3	0.0	-0.1
Total locomotion distance, hab. session 1	1.0	1.5	3.6	-0.1	1.5	1.9	-1.6	-0.4	0.4
Locomotion velocity, hab. session 1	1.2	1.7	4.2	0.1	1.5	2.0	-2.1	0.2	-0.0
Time in familiar zone, hab. session 2	0.1	0.1	0.4	-0.3	-0.3	-0.2	-0.1	0.0	-0.6
Time in novel zone, hab. session 2	0.2	0.2	0.6	-0.2	-0.0	-0.1	0.3	-0.8	0.5
Total zone transitions, hab. session 2	0.2	0.2	0.5	0.4	0.5	0.7	-0.4	0.0	0.4
Total locomotion distance, hab. session 2	0.5	0.7	1.2	0.0	0.9	1.0	-0.3	-1.0	1.1
Locomotion velocity, hab. session 2	0.5	0.7	1.4	0.1	1.0	1.2	-0.7	-0.7	0.9
Novel to familiar place preference ratio	0.3	0.3	0.6	-0.8	-0.6	-0.6	0.2	-0.5	-0.4
Novelty place preference	0.1	0.1	0.3	-0.5	-0.4	-0.4	0.2	-0.3	-0.2
Time in novel zone, NPP test	0.0	0.0	0.2	-0.4	-0.1	-0.0	-0.1	-0.2	-0.2
Total zone transitions, NPP test	0.7	1.0	2.0	0.7	1.4	1.4	-1.0	-0.0	0.8
Total locomotion distance, NPP test	1.4	1.9	3.9	0.8	1.9	2.0	-1.2	-0.4	1.3
Locomotion velocity, NPP test	1.3	1.8	3.7	0.9	1.8	1.9	-1.3	-0.1	1.1
Intraocular pressure	1.3	1.8	4.3	-0.7	-1.6	-1.8	2.1	-0.8	0.1
Delta distance traveled before/after self-admin	0.4	0.5	0.9	-0.9	-0.8	-0.6	0.0	-0.2	-0.9
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	-0.4	-0.2	-0.2	0.3	0.0	-0.3
Parametrial fat weight	2.5	5.8	10.3	-2.5	-3.2	-2.8	1.0	-0.5	-3.0
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.3	-0.1	-0.1	0.5	0.1	0.2
Pavlov. Cond. magazine entry latency	0.3	0.3	0.6	-0.8	-0.5	-0.6	-0.2	-0.5	-0.7
Pavlov. Cond. change in total contacts	0.6	0.6	1.4	-0.7	-1.0	-1.2	0.4	-0.6	-0.6
Pavlov. Cond. index score	0.2	0.2	0.9	-0.3	0.1	0.1	-1.0	-0.0	-0.6
Pavlov. Cond. latency score	0.2	0.2	1.1	0.1	0.3	0.1	-1.0	0.3	-0.5
Pavlov. Cond. lever contacts	0.2	0.2	0.5	-0.3	-0.1	-0.1	-0.7	0.1	-0.7
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	0.7	0.5	0.6	0.3	0.4	1.0
Pavlov. Cond. intertrial magazine entries	1.7	2.1	7.1	-0.2	0.6	0.3	1.5	-1.6	2.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.7	-0.2	0.1	-0.0	-0.8	0.1	-0.6
Pavlov. Cond. response bias	0.2	0.3	0.6	-0.8	-0.3	-0.3	-0.3	-0.5	-0.6
Pavlov. Cond. lever latency	0.9	1.3	3.0	-0.2	1.2	1.2	-0.1	-1.3	1.7
Pavlov. Cond. magazine entry latency	0.5	0.6	1.2	-0.2	-0.9	-1.1	0.2	0.6	-1.1
Pavlov. Cond. change in total contacts	0.6	1.0	1.5	0.3	-1.2	-1.2	0.4	1.2	-1.2
Pavlov. Cond. index score	1.1	1.4	2.7	0.0	-1.4	-1.5	0.5	1.2	-1.6
Pavlov. Cond. latency score	0.8	1.0	1.7	0.2	-1.1	-1.2	0.3	1.2	-1.3
Pavlov. Cond. lever contacts	0.9	1.2	2.3	0.5	-1.1	-1.1	0.2	1.5	-1.5
Pavlov. Cond. magazine entry number	1.3	1.6	3.1	0.7	1.6	1.6	-0.5	-0.8	1.8
Pavlov. Cond. intertrial magazine entries	0.7	1.0	2.7	0.2	1.3	1.7	-1.2	-0.3	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.5	2.8	-0.1	-1.5	-1.5	0.5	1.1	-1.7
Pavlov. Cond. response bias	1.0	1.4	3.5	-0.0	-1.3	-1.2	0.3	1.3	-1.9
Time in closed arm before self-admin	3.3	4.2	8.1	-0.8	-2.9	-2.7	2.2	0.3	-1.9
Time in closed arm after self-admin	3.1	3.3	7.5	-0.7	-2.6	-2.7	1.8	0.1	-1.4
Time in open arm before self-admin	1.0	1.0	2.5	0.4	1.2	1.3	-1.6	-0.0	0.7
Time in open arm after self-admin	1.9	2.1	4.1	-0.1	1.9	2.0	-1.5	-1.1	1.2
Bone: periosteal estimation	1.6	3.3	6.2	-2.5	-2.0	-1.6	1.7	-1.6	-1.1
Bone: periosteal perimeter	3.6	6.2	9.5	-2.9	-2.8	-2.5	3.1	-2.0	-1.1
Bone: post-yield work	0.1	0.2	0.3	-0.1	0.4	0.5	0.2	-0.4	0.6
Progressive ratio test 1 active lever presses	1.7	2.2	4.5	-1.0	-2.1	-2.0	1.4	0.4	-1.3
Progressive ratio test 1 breakpoint	1.6	1.9	4.1	-0.9	-2.0	-1.9	1.3	0.4	-1.2
Progressive ratio test 1 inactive lever presses	0.8	1.2	2.1	-0.7	-1.4	-1.3	1.2	-0.5	-0.9
Progressive ratio test 2 active lever presses	0.8	0.9	1.7	-0.9	-1.3	-1.1	1.0	-0.1	-0.7
Progressive ratio test 2 breakpoint	0.6	0.6	1.3	-0.8	-1.1	-1.0	0.8	-0.0	-0.6
Progressive ratio test 2 inactive lever presses	0.9	1.5	4.5	-0.9	-1.5	-1.1	2.1	-0.6	-0.3
Incentive Sensitization - Responses	0.0	0.1	0.1	-0.2	-0.4	-0.1	0.2	-0.3	-0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.1	-0.3	-0.1
Sum of active levers in priming session hrs 5-6	2.9	2.7	5.1	0.1	2.3	2.1	-0.5	-1.3	2.2
Progressive ratio	0.1	0.1	0.3	-0.0	0.1	0.2	0.1	-0.5	0.5
Food seeking constrained by brief footshock	1.8	2.2	4.8	-0.8	0.6	0.5	1.7	-2.1	2.2
Seeking ratio, punishment vs. effort	0.4	0.6	1.2	-0.4	0.7	0.6	0.4	-1.1	1.0
Retroperitoneal fat weight	2.1	9.0	12.6	-3.6	-3.5	-3.3	2.4	-2.4	-2.5
Reaction time number correct	0.4	0.7	1.2	-1.1	0.8	1.1	-0.9	-0.7	-0.5
Reaction time mean minus median	0.2	0.4	1.6	0.5	0.0	0.1	-0.4	1.3	-0.7
Reaction time mean minus median AUC	0.1	0.3	1.3	0.5	-0.2	0.0	0.2	1.1	-0.5
Reaction time num false alarms	0.7	1.0	2.5	-0.5	-1.1	-1.3	1.6	0.0	-0.3
Reaction time num false alarms AUC	0.5	0.8	2.4	-0.2	-0.9	-1.2	1.5	0.2	-0.1
Reaction time trials correct on left	0.4	0.7	1.2	-1.1	0.8	1.1	-0.9	-0.7	-0.5
Reaction time trials on left	0.4	0.7	1.3	-1.1	0.7	1.0	-0.9	-0.7	-0.6
Reaction time mean	0.7	1.0	1.9	-0.4	-1.3	-1.3	0.7	0.3	-1.4
Reaction time mean AUC	0.5	0.8	2.0	0.3	-0.9	-0.8	0.2	1.0	-1.4
Median of all reaction times	0.8	1.1	2.2	-0.4	-1.4	-1.5	1.0	-0.0	-1.1
Reaction time omissions	1.1	1.7	4.6	-0.7	-1.5	-1.2	0.5	0.9	-2.1
Reaction time false alarm rate	1.0	1.3	3.5	0.0	-1.3	-1.6	1.9	0.0	0.1
Reaction time premature initiation rate	0.3	0.5	0.9	0.7	0.8	0.9	-0.5	0.5	0.6
Reaction time premature initiations	0.3	0.5	1.4	0.0	0.9	1.2	-0.8	0.3	-0.0
Std. dev. reaction times	0.4	0.7	2.0	-0.2	-0.9	-0.8	0.0	0.7	-1.4
Reaction time trials completed	0.4	0.7	1.3	-1.1	0.7	1.0	-0.9	-0.7	-0.6
Reaction time trials AUC	0.4	0.8	1.7	-1.3	0.5	0.8	-0.7	-0.9	-0.7
Run reversals in cocaine runway, females	2.9	2.9	4.9	-1.7	-2.2	-1.7	1.9	-1.4	-1.1
Run reversals in cocaine runway, males	1.6	1.6	2.1	1.4	1.4	1.3	-1.2	1.5	0.4
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.1	-0.1	0.1	-0.5	0.0	-0.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	-0.6	-0.6	-0.3	-0.0	-0.5	-0.4
Latency to leave start box in cocaine runway, M	0.4	0.4	0.7	0.7	0.5	0.5	-0.8	0.8	-0.1
Std. dev. time between licks in bursts	1.6	2.2	3.8	-1.9	-1.7	-1.4	1.4	-1.4	-0.9
Total sessions with >9 infusions	3.3	4.0	6.4	-1.9	-2.5	-2.3	2.3	-1.2	-1.2
Short access day 1 total inactive lever presses	1.6	2.1	5.5	-0.8	-1.4	-1.3	2.4	-1.6	-0.1
Short access day 10 total inactive lever presses	0.6	1.5	6.2	2.5	0.3	0.4	-0.4	1.6	-0.1
Short access day 1 total infusions	3.3	4.4	6.1	-2.5	-2.2	-2.1	2.4	-2.0	-0.8
Short access day 10 total infusions	1.0	1.3	2.6	-1.0	-1.3	-0.9	1.6	-1.4	-0.1
Short access total infusions	1.8	2.3	3.9	-1.5	-2.0	-1.6	1.9	-0.8	-0.9
Short access day 1 locomotion	5.2	6.4	9.9	-2.3	-3.1	-3.1	2.8	-2.1	-1.1
Short access day 10 total locomotion	1.4	2.6	5.1	-2.1	-1.4	-1.1	1.6	-2.3	-0.4
Short access total locomotion	2.8	3.3	5.0	-2.1	-2.1	-1.9	2.2	-1.6	-0.5
One hour access (0.3 mA shock)	1.3	1.5	4.1	-0.9	-0.9	-1.0	2.0	-1.5	0.6
Compulsive drug intake	0.6	0.8	1.3	1.1	1.0	1.0	-0.2	0.3	1.0
One hour access (shock baseline)	1.8	2.8	4.0	-1.7	-2.0	-2.0	1.9	-1.3	-0.7
Social response proportion	3.9	4.4	7.3	-2.2	-1.6	-1.8	2.7	-2.7	1.1
Social responses	1.3	1.7	5.1	-1.4	-0.1	-0.3	1.1	-2.3	1.2
Social time	0.5	0.6	2.0	0.5	-0.1	-0.4	1.1	-0.5	1.4
Soleus weight	0.8	2.3	4.3	-1.2	-2.0	-1.7	0.9	0.2	-2.1
Bone: stiffness	3.1	5.1	8.1	-2.5	-2.8	-2.6	2.4	-1.3	-1.4
Tibialis anterior weight	0.1	0.2	0.6	-0.5	-0.2	-0.1	-0.3	-0.1	-0.8
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.1	-0.9	-0.3	0.1	1.0	-0.8	-0.0
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.8	-0.1	-0.7	-0.5	-0.9	0.4	-0.9
Time to tail flick, test, before self-admin	2.1	2.2	5.9	-0.8	-1.5	-1.8	2.4	-1.0	0.0
Time to tail flick, test, after self-admin	0.3	0.3	0.9	0.4	0.7	0.5	0.6	-0.2	1.0
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.6	1.0	0.3	0.1	-1.3	0.8	-0.1
Delta time to tail flick, test, before/after SA	0.9	0.9	2.0	0.0	1.2	1.4	-1.3	-0.1	0.4
Tibia length	0.4	1.0	1.5	-1.0	-1.2	-1.1	1.2	-0.7	-0.3
Ambulatory time before self-admin	0.8	1.2	2.8	-0.4	-1.5	-1.3	-0.2	0.7	-1.7
Ambulatory time after self-admin	1.2	1.4	2.7	-1.2	-1.6	-1.3	0.3	-0.1	-1.6
Bone: tissue strength	0.8	0.8	2.2	0.0	-0.5	-0.1	-1.1	1.0	-1.5
Total heroin consumption	0.4	0.5	1.3	-0.0	-0.5	-0.4	-0.1	1.1	-1.0
Bone: trabecular number	2.2	3.6	10.3	-2.7	-0.8	-1.2	1.3	-3.2	0.3
Bone: trabecular spacing	0.4	0.5	1.7	0.7	0.1	0.5	-0.6	1.3	-0.4
Bone: trabecular thickness	1.3	1.6	4.6	-1.8	-0.3	-0.8	1.0	-2.2	0.6
Bone: trabecular tissue density	0.7	1.1	3.0	-0.1	1.0	1.3	-1.7	0.7	-0.6
Water consumed over 24 hours	0.2	0.2	0.5	-0.7	0.2	0.4	-0.2	-0.6	0.1
Number of responses in last shaping day	1.2	1.3	3.6	-1.2	-0.2	-0.0	1.5	-1.9	0.6