Hub : Genes

Crip2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Crip2	0.06	0.04	3.3e-07	0.07	0.08	0.07	0.07	2.1e-07	9.4e-08	2.0e-07	2.4e-07
2	pVTA	gene expression	Crip2	0.15	0.1	8.3e-07	0.12	0.13	0.11	0.11	9.0e-06	2.2e-06	2.5e-05	1.6e-05
3	Liver	gene expression	Crip2	0.08	0.06	6.0e-09	0.05	0.06	0.05	0.05	6.9e-06	7.4e-07	2.9e-06	6.1e-06
4	LHb	gene expression	Crip2	0.18	0.12	1.2e-04	0.09	0.15	0.14	0.14	3.4e-03	2.1e-04	2.8e-04	4.3e-04
5	Adipose	gene expression	Crip2	0.1	0.07	2.2e-12	0.1	0.1	0.1	0.1	1.0e-10	5.3e-11	3.1e-11	5.4e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.0	-0.0
Area under the delay curve	1.4	1.5	1.8	1.2	1.3	1.3	1.1	-1.1
BMI with tail	1.2	3.9	6.0	2.1	2.2	2.5	1.6	-1.3
BMI without tail	0.7	1.3	2.0	1.2	1.3	1.4	1.0	-0.7
Body weight	2.1	8.8	12.1	-2.9	-2.7	-2.5	-3.2	3.5
Weight adjusted by age	0.3	0.3	0.8	-0.4	-0.3	-0.3	-0.6	0.9
Bone surface	0.4	0.8	1.4	0.8	0.7	0.6	1.0	-1.2
Bone volume	0.4	0.7	1.2	0.7	0.6	0.5	1.0	-1.1
Breakpoint value in progressive ratio session	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.2	0.1
Number of licking bursts	1.3	1.5	1.5	1.2	1.2	1.2	1.2	-1.2
Context. condit. distance diff. score	2.9	3.5	4.4	-2.0	-2.0	-2.1	-1.7	1.6
Locomotion velocity, session 1	0.5	0.5	1.0	-0.6	-0.4	-0.3	-1.0	1.0
Locomotion distance, session 1	0.1	0.1	0.3	0.3	0.4	0.5	-0.1	0.3
Locomotion velocity, session 2	0.2	0.3	0.6	0.5	0.7	0.8	0.1	-0.1
Locomotion distance, session 2	0.5	0.8	1.2	0.9	1.0	1.1	0.6	-0.6
Locomotion velocity, session 3	0.0	0.0	0.0	0.1	0.1	0.2	-0.1	-0.2
Locomotion distance, session 3	0.0	0.0	0.1	0.2	0.2	0.3	-0.1	-0.1
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.2	-0.3	-0.3	-0.2	0.1
Stereotopy head waving duration, day 3	0.0	0.0	0.1	-0.2	-0.2	-0.3	-0.0	-0.0
Locomotion velocity, session 7	0.1	0.1	0.1	-0.2	-0.3	-0.4	-0.0	-0.1
Locomotion distance, session 7	0.8	1.0	1.1	1.0	1.0	1.0	1.0	-1.0
Stereotopy head waving bouts, day 7	2.3	2.6	3.4	-1.7	-1.8	-1.9	-1.5	1.2
Stereotopy head waving duration, day 7	1.5	1.9	2.5	-1.4	-1.5	-1.6	-1.2	1.0
Locomotion velocity, session 8	2.4	2.9	3.1	-1.7	-1.8	-1.7	-1.7	1.6
Locomotion distance, session 8	0.4	0.6	0.6	-0.8	-0.8	-0.8	-0.8	0.7
Degree of sensitization distance	0.3	0.3	0.5	0.5	0.4	0.4	0.7	-0.6
Degree of sensitization stereotypy	1.0	1.1	1.4	-1.1	-1.2	-1.2	-0.9	0.8
Conditioned locomotion	2.0	2.3	2.7	-1.5	-1.5	-1.4	-1.6	1.6
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.2	-0.2	-0.0	-0.5	0.5
Cocaine response after cond. not corrected	0.1	0.2	0.4	0.3	0.4	0.6	-0.2	0.3
Cocaine response before conditioning	2.0	2.5	3.6	1.6	1.8	1.9	1.3	-1.1
Saline control response	0.0	0.0	0.1	-0.2	-0.3	-0.2	-0.3	-0.0
Bone: connectivity density	0.3	0.5	0.6	-0.8	-0.8	-0.8	-0.7	0.6
Bone: cortical apparent density	3.8	5.0	5.3	-2.3	-2.2	-2.3	-2.2	2.2
Bone: cortical area	0.2	0.2	0.5	-0.2	-0.4	-0.7	0.3	-0.7
Bone: cortical porosity	0.1	0.1	0.2	-0.3	-0.4	-0.5	-0.2	0.0
Bone: cortical porosity	0.2	0.2	0.3	-0.4	-0.5	-0.5	-0.3	0.2
Bone: cortical thickness	0.5	0.8	1.5	-0.9	-1.1	-1.2	-0.5	0.3
Bone: cortical thickness	0.3	0.4	0.7	-0.6	-0.7	-0.9	-0.4	0.1
Bone: cortical tissue density	3.8	5.0	5.2	-2.3	-2.2	-2.2	-2.2	2.2
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	0.4	0.5	0.5	0.2	-0.3
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.7	1.2	1.2	1.3	1.1	-1.0
Condit. Reinf. active responses	0.2	0.3	0.5	-0.4	-0.3	-0.2	-0.7	0.7
Condit. Reinf. inactive responses	2.6	3.1	3.9	-1.8	-1.7	-1.6	-2.0	1.8
Incentive salience index mean	0.1	0.1	0.3	-0.3	-0.2	-0.0	-0.6	0.6
Condit. Reinf. lever presses	0.5	0.6	1.1	-0.7	-0.6	-0.5	-0.9	1.1
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	-0.7	-0.6	-0.5	-0.9	0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.3	-0.2	-0.3	-0.2	0.3
Condit. Reinf. active responses	0.1	0.1	0.2	-0.1	0.1	0.2	-0.4	0.5
Condit. Reinf. inactive responses	0.2	0.2	0.5	0.4	0.6	0.7	0.0	0.1
Condit. Reinf. lever presses	2.0	2.7	3.2	1.7	1.8	1.8	1.5	-1.5
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	-0.1	0.1	0.2	-0.4	0.5
Conditioned reinforcement - actives	0.8	0.8	0.9	-0.9	-0.9	-0.9	-0.9	0.9
Conditioned reinforcement - inactives	0.5	0.6	1.1	-0.8	-0.6	-0.5	-1.1	0.9
Conditioned locomotion	0.0	0.0	0.0	0.0	0.0	0.1	-0.0	0.0
Patch foraging indifference point 0 sec	7.4	11.8	12.8	-3.5	-3.4	-3.3	-3.6	3.4
Patch foraging indifference point AUC	9.3	10.7	12.8	-3.2	-3.1	-2.8	-3.6	3.6
Delay disc. indifference point, 0s delay	0.4	0.5	0.6	-0.7	-0.6	-0.6	-0.7	0.8
Delay disc. indifference point, 16s delay	1.7	1.7	2.0	1.3	1.4	1.4	1.1	-1.3
Delay disc. indifference point, 2s delay	4.6	5.1	5.3	2.2	2.3	2.2	2.3	-2.3
Delay disc. indifference point, 24s delay	1.2	1.1	1.7	1.1	1.2	1.3	0.8	-0.8
Delay disc. indifference point, 4s delay	0.5	0.5	0.7	0.7	0.8	0.8	0.5	-0.5
Delay disc. indifference point, 8s delay	0.4	0.4	0.6	0.6	0.8	0.8	0.4	-0.4
Indifference point function ln k	0.1	0.2	0.4	-0.5	-0.5	-0.6	-0.2	0.1
Indifference point function log k	0.1	0.2	0.4	-0.5	-0.5	-0.6	-0.2	0.1
Patch foraging total patch changes 0 sec	8.9	14.4	15.6	-3.8	-3.8	-3.6	-4.0	3.8
Patch foraging total patch changes 12 sec	4.8	6.2	7.7	-2.5	-2.3	-2.1	-2.8	2.7
Patch foraging total patch changes 18 sec	3.5	4.5	5.6	-2.1	-2.0	-1.9	-2.4	2.2
Patch foraging total patch changes 24 sec	2.0	2.4	3.1	-1.5	-1.5	-1.3	-1.7	1.6
Patch foraging total patch changes 6 sec	8.9	13.2	15.7	-3.6	-3.5	-3.2	-4.0	3.9
Patch foraging time to switch 0 sec	13.0	20.1	21.0	4.6	4.4	4.3	4.6	-4.5
Patch foraging water rate 0 sec	17.4	28.0	29.5	-5.4	-5.3	-5.3	-5.3	5.1
Patch foraging water rate 12 sec	5.4	8.2	9.9	-2.9	-2.6	-2.5	-3.1	3.1
Patch foraging water rate 18 sec	3.7	5.0	5.7	-2.3	-2.1	-2.0	-2.4	2.4
Patch foraging water rate 24 sec	3.1	4.4	5.8	-2.1	-1.8	-1.7	-2.3	2.4
Patch foraging water rate 6 sec	4.2	6.1	6.4	-2.5	-2.4	-2.4	-2.5	2.5
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.5	-0.7	-0.7	-0.6	-0.7	0.4
Distance traveled before self-admin	0.7	0.7	1.2	0.9	1.0	1.1	0.5	-0.6
Distance traveled after self-admin	0.0	0.0	0.1	-0.2	-0.1	-0.2	-0.0	0.0
Extensor digitorum longus weight	9.3	36.7	42.1	-6.3	-6.4	-6.5	-5.7	5.3
Bone: elastic displacement	0.2	0.2	0.4	0.3	0.3	0.2	0.6	-0.7
Bone: elastic work	1.2	1.6	2.1	1.2	1.2	1.0	1.4	-1.5
Bone: endosteal estimation	2.0	4.4	6.1	2.0	1.9	1.7	2.3	-2.5
Bone: endosteal perimeter	0.4	0.8	1.7	0.8	0.7	0.6	1.0	-1.3
Epididymis fat weight	1.5	3.5	4.6	2.0	2.0	2.1	1.7	-1.5
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.4	-0.3	-0.2	-0.5	0.5
Delta time in open arm before/after self-admin	0.9	0.9	1.3	-0.9	-1.0	-1.1	-0.7	0.7
Diff in mean of infusions in LGA sessions	0.9	1.0	1.2	-1.0	-1.1	-1.0	-1.0	0.9
Delay discount exponential model param	1.1	1.2	1.5	-1.1	-1.2	-1.2	-0.9	1.0
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.1	-0.0	-0.1	0.2	-0.2
Active lever presses in extinction session 6	1.2	1.2	1.5	-1.2	-1.2	-1.2	-1.0	0.9
Bone: final force	0.7	1.2	2.8	0.8	0.6	0.3	1.4	-1.7
Bone: final moment	0.6	0.9	2.4	0.6	0.3	0.0	1.3	-1.5
Food consumed during 24 hour testing period	1.1	1.3	1.5	-1.2	-1.1	-1.0	-1.2	1.2
Glucose	0.1	0.1	0.3	0.1	0.0	-0.1	0.4	-0.5
Heart weight	0.3	0.5	1.0	0.6	0.5	0.3	0.8	-1.0
Delay discount hyperbolic model param	1.5	1.5	1.9	-1.2	-1.4	-1.4	-1.1	1.2
Intermittent access intake day 1-15 change	1.4	1.4	1.6	1.2	1.2	1.3	1.0	-1.1
Intermittent access intake escalation	1.4	1.4	1.5	1.2	1.2	1.2	1.1	-1.2
Intermittent access intake escalation 2	0.2	0.2	0.4	0.5	0.3	0.3	0.6	-0.6
Intermitt. access day 1 inactive lever presses	3.2	3.5	4.3	-1.9	-1.8	-1.6	-2.1	1.9
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.5	-0.7	-0.6	-0.6	-0.7	0.6
Intermitt. access escalation Index	0.0	0.0	0.1	-0.1	-0.0	0.0	-0.2	0.1
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.3	-0.3	-0.3	-0.5	0.4
Intermittent access day 15 total infusions	0.7	0.8	1.0	0.9	0.9	1.0	0.8	-0.9
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.4	1.1	1.1	1.2	0.9	-1.0
Intermittent access total infusions	0.0	0.0	0.1	0.2	0.2	0.3	0.1	-0.2
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.0	0.0	0.1	-0.0	0.0
Intermittent access day 15 total locomotion	0.0	0.0	0.1	0.1	0.2	0.3	-0.0	0.0
Intermittent access total locomotion	0.1	0.1	0.1	-0.3	-0.2	-0.2	-0.4	0.4
Intermittent access standard deviation	0.2	0.2	0.6	0.5	0.6	0.8	-0.0	0.0
Left kidney weight	3.0	8.4	8.9	-3.0	-3.0	-3.0	-2.8	2.8
Right kidney weight	1.4	4.0	4.2	-2.0	-2.0	-2.0	-1.9	1.9
Cocaine induced anxiety	0.2	0.3	0.4	-0.5	-0.6	-0.7	-0.4	0.4
Post-drug Anxiety	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.5	0.4
Baseline Anxiety	0.5	0.5	0.7	0.7	0.8	0.8	0.6	-0.7
Tail length	5.0	15.0	15.9	-4.0	-3.9	-4.0	-3.7	3.7
Length with tail	9.9	36.3	37.5	-6.1	-6.1	-6.0	-6.0	6.0
Length without tail	6.7	14.7	15.2	-3.9	-3.8	-3.7	-3.9	3.9
Times rat made contact with spout	0.4	0.5	0.9	-0.6	-0.5	-0.4	-0.9	0.8
Lifetime Intake	0.1	0.1	0.2	0.3	0.4	0.4	0.3	-0.4
Liver weight, left	2.8	4.5	4.6	-2.1	-2.1	-2.1	-2.1	2.1
Liver weight, right	1.1	1.9	3.1	-1.3	-1.1	-0.9	-1.7	1.8
Locomotor activity	0.1	0.2	0.3	-0.4	-0.3	-0.3	-0.4	0.6
Locomotor testing distance	0.0	0.1	0.1	-0.3	-0.2	-0.3	-0.3	0.3
Locomotor testing rearing	1.6	2.5	3.5	1.6	1.7	1.9	1.3	-1.4
Locomotion in novel chamber	2.6	3.2	3.7	-1.8	-1.7	-1.8	-1.7	1.9
Locomotion in novel chamber post-restriction	0.3	0.3	0.5	0.5	0.5	0.5	0.6	-0.7
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.4	0.3	0.4	0.3	-0.3
Change in fecal boli incidents, locomotor task	1.7	1.6	1.9	-1.3	-1.2	-1.1	-1.4	1.3
Time >=10cm from walls, locomotor time 1	4.3	4.3	5.8	-2.0	-1.9	-1.7	-2.3	2.4
Bouts of movement, locomotor time 1	1.2	1.3	1.6	1.2	1.1	1.1	1.1	-1.3
Total resting periods, locomotor time 1	1.6	1.7	2.2	1.3	1.2	1.2	1.3	-1.5
Rest time, locomotor task time 1	0.4	0.5	0.6	0.7	0.8	0.8	0.5	-0.7
Distance moved, locomotor task time 1	1.1	1.2	1.8	1.1	1.1	0.9	1.3	-1.1
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.3	0.3	0.2	0.4	-0.0
Time >=10cm from walls, locomotor time 2	3.2	3.4	4.0	-1.8	-1.8	-1.7	-1.8	2.0
Bouts of movement, locomotor time 2	0.3	0.3	0.9	0.3	0.3	0.1	0.7	-1.0
Total resting periods, locomotor time 2	0.3	0.4	0.8	0.4	0.5	0.3	0.7	-0.9
Rest time, locomotor task time 2	0.1	0.1	0.2	0.2	0.3	0.4	0.0	-0.0
Distance moved, locomotor task time 2	0.4	0.5	0.8	0.7	0.6	0.5	0.9	-0.7
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.2	-0.3	-0.3	-0.1	0.1
Light reinforcement 1	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.2
Light reinforcement 2	1.1	1.4	1.7	1.3	1.3	1.2	1.3	-0.9
Bone: marrow area	2.0	4.4	6.1	2.0	1.9	1.7	2.3	-2.5
Bone: maximum diameter	0.4	0.7	1.4	0.7	0.5	0.4	1.0	-1.2
Bone: maximum force	0.3	0.4	1.3	0.3	0.1	-0.1	0.9	-1.1
Bone: maximum moment	0.2	0.3	1.0	0.1	-0.1	-0.3	0.7	-1.0
Mean time between licks in bursts	0.5	0.7	0.9	0.9	0.9	1.0	0.8	-0.6
Mean num. licks in bursts	1.9	2.2	2.6	-1.5	-1.5	-1.4	-1.6	1.5
Cd content in liver	0.6	0.7	1.0	-0.8	-0.7	-0.6	-1.0	1.0
Co content in liver	0.9	1.1	1.2	-1.1	-1.1	-1.1	-1.1	0.9
Cu content in liver	2.4	2.9	3.1	1.8	1.7	1.7	1.7	-1.6
Fe content in liver	1.4	1.6	2.2	1.3	1.1	1.0	1.5	-1.4
K content in liver	1.7	1.7	2.8	-1.2	-1.1	-1.0	-1.4	1.7
Mg content in liver	0.3	0.3	0.6	-0.5	-0.4	-0.3	-0.6	0.8
Mn content in liver	0.1	0.1	0.2	-0.3	-0.4	-0.5	0.1	-0.1
Na content in liver	0.0	0.0	0.1	-0.1	-0.1	-0.0	-0.1	0.3
Rb content in liver	0.2	0.2	0.2	-0.5	-0.4	-0.5	-0.5	0.4
Se content in liver	0.0	0.0	0.1	-0.0	0.1	0.2	-0.3	0.3
Sr content in liver	0.1	0.1	0.1	0.2	0.3	0.3	0.0	-0.1
Zn content in liver	0.1	0.1	0.1	0.2	0.2	0.2	0.2	-0.3
Bone: minimum diameter	0.2	0.4	1.0	-0.6	-0.8	-1.0	-0.2	-0.2
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.2	0.0	-0.1	0.4	-0.6
Time in novel zone, hab. session 1	0.7	0.7	1.2	0.8	1.0	1.1	0.5	-0.4
Total zone transitions, hab. session 1	0.8	1.1	1.3	1.0	1.0	0.9	1.1	-1.1
Total locomotion distance, hab. session 1	0.0	0.1	0.1	0.1	0.1	-0.0	0.4	-0.4
Locomotion velocity, hab. session 1	0.2	0.2	0.4	-0.5	-0.5	-0.7	-0.3	0.3
Time in familiar zone, hab. session 2	0.7	0.7	0.9	-0.8	-0.8	-0.8	-0.9	0.9
Time in novel zone, hab. session 2	1.2	1.2	1.3	1.1	1.1	1.1	1.1	-1.1
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.3	0.4	0.5	-0.0	0.1
Total locomotion distance, hab. session 2	0.2	0.2	0.4	-0.5	-0.4	-0.4	-0.6	0.5
Locomotion velocity, hab. session 2	0.3	0.4	0.4	-0.6	-0.6	-0.6	-0.6	0.5
Novel to familiar place preference ratio	0.9	1.0	1.0	1.0	1.0	0.9	1.0	-1.0
Novelty place preference	1.2	1.2	1.3	1.1	1.1	1.0	1.1	-1.1
Time in novel zone, NPP test	0.4	0.4	0.5	0.7	0.7	0.6	0.7	-0.7
Total zone transitions, NPP test	1.1	1.5	2.8	-1.1	-0.9	-0.6	-1.6	1.7
Total locomotion distance, NPP test	0.5	0.7	1.1	-0.8	-0.7	-0.6	-1.0	1.1
Locomotion velocity, NPP test	0.2	0.3	0.5	-0.6	-0.5	-0.4	-0.7	0.7
Intraocular pressure	0.4	0.5	0.6	0.7	0.7	0.7	0.7	-0.7
Delta distance traveled before/after self-admin	0.2	0.2	0.6	-0.5	-0.6	-0.8	-0.0	0.0
Delta ambulatory time before/after self-admin	0.6	0.6	1.3	-0.8	-0.9	-1.2	-0.4	0.3
Parametrial fat weight	0.1	0.2	0.2	0.4	0.5	0.5	0.3	-0.3
Pavlov. Cond. lever latency	0.1	0.2	0.5	0.1	0.0	-0.2	0.5	-0.7
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	0.2	-0.0	-0.1	0.6	-0.7
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.2	0.3
Pavlov. Cond. index score	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.0
Pavlov. Cond. latency score	0.0	0.0	0.0	0.0	-0.0	0.0	0.0	0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.4	0.4	0.5	0.2	0.0
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.0	0.2	0.2	-0.2	0.1
Pavlov. Cond. intertrial magazine entries	8.6	10.4	10.9	-3.3	-3.3	-3.2	-3.3	3.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.1	-0.0	-0.0	0.1	-0.0
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2	0.3
Pavlov. Cond. lever latency	3.1	4.2	5.0	-2.1	-2.2	-2.2	-1.9	1.7
Pavlov. Cond. magazine entry latency	2.9	3.3	5.0	1.9	2.1	2.2	1.4	-1.3
Pavlov. Cond. change in total contacts	6.4	8.8	9.1	3.0	3.0	3.0	2.9	-2.9
Pavlov. Cond. index score	4.2	5.4	7.1	2.4	2.6	2.7	2.0	-1.9
Pavlov. Cond. latency score	3.5	4.3	6.1	2.2	2.3	2.5	1.7	-1.5
Pavlov. Cond. lever contacts	3.1	4.3	5.5	2.1	2.3	2.3	1.8	-1.7
Pavlov. Cond. magazine entry number	2.7	3.3	4.7	-1.9	-2.0	-2.2	-1.4	1.4
Pavlov. Cond. intertrial magazine entries	4.6	6.0	6.3	-2.5	-2.4	-2.4	-2.4	2.5
Pavlov. Cond. lever-magazine prob. diff.	4.9	6.2	8.0	2.6	2.7	2.8	2.2	-2.0
Pavlov. Cond. response bias	3.1	4.3	5.8	2.1	2.3	2.4	1.7	-1.6
Time in closed arm before self-admin	8.5	9.6	9.9	3.1	3.2	3.1	3.0	-3.0
Time in closed arm after self-admin	7.1	7.3	8.0	2.7	2.8	2.8	2.5	-2.6
Time in open arm before self-admin	7.1	7.7	9.1	-2.8	-2.6	-2.5	-2.9	3.0
Time in open arm after self-admin	11.1	12.2	12.9	-3.5	-3.6	-3.6	-3.3	3.4
Bone: periosteal estimation	0.9	1.9	4.1	1.2	1.0	0.7	1.7	-2.0
Bone: periosteal perimeter	0.1	0.2	0.6	0.3	0.1	0.0	0.5	-0.8
Bone: post-yield work	1.6	2.2	3.3	-1.6	-1.7	-1.8	-1.2	0.9
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.3	0.3	0.3	0.1	-0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.4	0.4	0.4	0.3	-0.4
Progressive ratio test 1 inactive lever presses	1.9	2.1	2.3	-1.5	-1.4	-1.4	-1.5	1.5
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.1	0.2	0.3	-0.0	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.0	0.1	0.1	-0.1	0.0
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.1	0.1	0.1	-0.2	0.0
Incentive Sensitization - Responses	0.1	0.1	0.2	0.3	0.4	0.5	0.2	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.3	0.4	0.4	0.2	-0.2
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.4	0.4	0.4	0.4	-0.6
Progressive ratio	2.0	2.3	2.9	1.4	1.5	1.4	1.6	-1.7
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.0	-0.0	-0.1	0.2	-0.5
Seeking ratio, punishment vs. effort	1.0	1.3	1.5	-1.1	-1.2	-1.2	-1.0	1.0
Retroperitoneal fat weight	0.0	0.1	0.1	0.3	0.3	0.4	0.1	-0.1
Reaction time number correct	3.8	5.5	6.7	-2.4	-2.5	-2.6	-2.2	2.0
Reaction time mean minus median	0.0	0.0	0.1	0.1	0.2	0.3	0.0	0.2
Reaction time mean minus median AUC	0.0	0.0	0.0	0.1	0.2	0.2	0.1	-0.1
Reaction time num false alarms	1.9	2.6	2.7	-1.6	-1.6	-1.6	-1.5	1.5
Reaction time num false alarms AUC	2.0	2.7	3.0	-1.7	-1.7	-1.7	-1.5	1.6
Reaction time trials correct on left	3.8	5.5	6.7	-2.4	-2.5	-2.6	-2.2	2.0
Reaction time trials on left	3.9	5.5	6.7	-2.4	-2.5	-2.6	-2.2	2.0
Reaction time mean	2.2	3.1	3.4	1.8	1.8	1.8	1.7	-1.6
Reaction time mean AUC	1.4	1.8	2.1	1.4	1.4	1.4	1.3	-1.2
Median of all reaction times	2.1	2.9	3.1	1.7	1.8	1.7	1.7	-1.6
Reaction time omissions	0.8	1.0	1.1	-1.1	-1.0	-1.0	-1.0	1.0
Reaction time false alarm rate	0.1	0.2	0.3	-0.4	-0.4	-0.4	-0.4	0.5
Reaction time premature initiation rate	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.3	0.2
Reaction time premature initiations	1.8	2.5	3.2	-1.7	-1.7	-1.8	-1.5	1.2
Std. dev. reaction times	1.4	2.0	2.2	1.4	1.5	1.5	1.4	-1.2
Reaction time trials completed	3.9	5.5	6.7	-2.4	-2.5	-2.6	-2.2	2.0
Reaction time trials AUC	4.1	5.8	7.0	-2.5	-2.6	-2.6	-2.2	2.1
Run reversals in cocaine runway, females	3.9	3.8	4.6	1.9	1.8	1.7	2.1	-2.2
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.2	0.2	0.2	0.2	-0.3
Latency to leave start box in cocaine runway	1.0	1.1	1.1	1.0	1.1	1.0	1.0	-1.0
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	0.5	0.5	0.6	0.5	-0.4
Latency to leave start box in cocaine runway, M	0.9	0.9	1.0	0.9	0.9	0.9	1.0	-1.0
Std. dev. time between licks in bursts	0.0	0.1	0.1	-0.2	-0.3	-0.3	-0.1	-0.0
Total sessions with >9 infusions	0.0	0.0	0.1	0.2	0.2	0.2	0.1	-0.1
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.1	0.2	0.3	-0.1	0.2
Short access day 10 total inactive lever presses	0.2	0.2	0.5	-0.5	-0.3	-0.2	-0.7	0.7
Short access day 1 total infusions	0.0	0.0	0.0	0.0	0.1	0.1	0.0	-0.2
Short access day 10 total infusions	0.2	0.3	0.3	0.5	0.5	0.6	0.4	-0.5
Short access total infusions	0.9	1.0	1.3	0.9	1.0	0.9	0.9	-1.1
Short access day 1 locomotion	0.4	0.4	0.5	0.6	0.7	0.7	0.5	-0.5
Short access day 10 total locomotion	0.0	0.0	0.1	-0.1	-0.0	0.1	-0.3	0.4
Short access total locomotion	0.0	0.0	0.1	0.0	0.2	0.3	-0.2	0.3
One hour access (0.3 mA shock)	0.7	0.8	1.0	-0.9	-0.8	-0.7	-1.0	1.0
Compulsive drug intake	1.0	1.0	1.5	-0.9	-0.9	-0.8	-1.0	1.2
One hour access (shock baseline)	0.1	0.2	0.3	0.4	0.4	0.4	0.4	-0.5
Social response proportion	0.5	0.5	0.6	0.7	0.8	0.8	0.7	-0.5
Social responses	0.5	0.7	0.7	0.8	0.9	0.8	0.8	-0.8
Social time	0.1	0.1	0.3	0.2	0.3	0.1	0.5	-0.5
Soleus weight	2.4	7.1	7.7	-2.7	-2.8	-2.7	-2.7	2.5
Bone: stiffness	0.7	1.0	1.8	-1.1	-1.2	-1.3	-0.7	0.4
Tibialis anterior weight	0.9	3.2	3.7	-1.8	-1.9	-1.9	-1.7	1.5
Time to tail flick, vehicle, before self-admin	3.4	3.5	4.9	-1.8	-1.6	-1.5	-2.1	2.2
Time to tail flick, vehicle, after self-admin	1.2	1.3	1.6	-1.1	-1.1	-1.0	-1.2	1.3
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.4	0.4	0.3	0.4	-0.6
Time to tail flick, test, after self-admin	6.0	6.2	7.2	-2.4	-2.4	-2.3	-2.5	2.7
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.4	-0.3	-0.5	-0.6	0.1	-0.0
Delta time to tail flick, test, before/after SA	6.5	5.9	7.5	-2.4	-2.3	-2.2	-2.5	2.7
Tibia length	0.1	0.3	0.4	-0.5	-0.5	-0.5	-0.5	0.6
Ambulatory time before self-admin	0.8	0.8	1.5	0.9	1.1	1.2	0.5	-0.7
Ambulatory time after self-admin	0.2	0.2	0.3	0.4	0.5	0.4	0.5	-0.5
Bone: tissue strength	0.6	0.6	1.0	0.7	0.6	0.4	1.0	-1.0
Total heroin consumption	2.9	3.4	3.5	-1.8	-1.9	-1.8	-1.9	1.8
Bone: trabecular number	0.2	0.4	0.4	-0.6	-0.6	-0.7	-0.6	0.5
Bone: trabecular spacing	0.1	0.1	0.2	0.3	0.2	0.2	0.5	-0.3
Bone: trabecular thickness	0.1	0.1	0.3	-0.3	-0.2	-0.2	-0.5	0.5
Bone: trabecular tissue density	0.0	0.0	0.0	0.0	-0.0	-0.1	0.2	-0.1
Water consumed over 24 hours	1.1	1.3	1.5	-1.2	-1.1	-1.1	-1.2	1.1
Number of responses in last shaping day	0.8	0.8	0.9	0.9	0.9	0.8	0.9	-0.9