Hub : Genes

Crh

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	gene expression	Crh	0.2	0.11	6.8e-04	0.05	0.04	0.05	0.04	2.2e-02	4.7e-02	2.5e-02	3.6e-02
2	PL	gene expression	Crh	0.1	0.05	3.1e-11	0.09	0.09	0.09	0.1	9.6e-10	4.2e-10	6.3e-10	1.4e-10
3	IL	gene expression	Crh	0.14	0.08	6.7e-03	0.05	-0.01	-0.01	0	2.7e-02	6.2e-01	6.3e-01	3.0e-01
4	IC	gene expression	Crh	0.28	0.13	1.2e-06	0.08	0.15	0.12	0.16	2.8e-04	6.0e-07	8.8e-06	3.7e-07
5	pVTA	gene expression	Crh	0.06	0.03	3.6e-03	-0	0.01	0.01	0	3.7e-01	2.6e-02	7.2e-02	2.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.9	1.6	2.9	-1.2	1.0	-1.7	1.1	1.2
Area under the delay curve	0.1	0.1	0.4	0.6	-0.0	-0.1	0.1	0.4
BMI with tail	1.5	5.3	8.8	3.0	-2.0	2.8	-1.6	-1.9
BMI without tail	0.9	4.9	7.8	2.8	-2.2	2.4	-1.8	-1.6
Body weight	1.4	6.0	10.3	2.9	-2.0	3.2	-1.8	-2.0
Weight adjusted by age	0.0	0.1	0.3	0.2	-0.5	0.6	0.1	0.2
Bone surface	0.0	0.1	0.4	-0.1	0.2	-0.6	0.2	0.1
Bone volume	0.0	0.0	0.2	-0.0	0.0	-0.4	0.1	0.1
Breakpoint value in progressive ratio session	0.5	1.0	2.0	0.6	-1.4	0.9	-1.1	-0.5
Number of licking bursts	0.4	1.4	2.4	1.0	-1.0	1.6	-1.0	-1.2
Context. condit. distance diff. score	0.5	0.6	1.3	-0.1	0.5	0.8	1.2	1.0
Locomotion velocity, session 1	0.1	0.1	0.4	0.7	-0.2	0.2	-0.1	0.2
Locomotion distance, session 1	0.1	0.1	0.1	0.2	0.3	-0.4	0.1	-0.3
Locomotion velocity, session 2	1.6	1.9	4.5	2.1	-1.3	0.9	-1.4	-0.7
Locomotion distance, session 2	0.1	0.2	0.4	0.2	0.5	-0.6	0.3	0.0
Locomotion velocity, session 3	0.6	0.7	1.6	1.3	-0.7	0.9	-0.6	-0.4
Locomotion distance, session 3	0.5	0.5	1.3	1.1	-0.6	0.9	-0.4	0.1
Stereotopy head waving bouts, day 3	0.3	0.3	0.6	-0.8	0.6	-0.5	0.6	0.3
Stereotopy head waving duration, day 3	0.3	0.4	0.9	-0.9	0.3	-0.7	-0.1	-0.7
Locomotion velocity, session 7	3.0	3.3	4.3	-2.1	1.9	-1.7	1.8	1.6
Locomotion distance, session 7	2.2	2.9	5.3	-2.3	1.6	-1.4	1.6	1.4
Stereotopy head waving bouts, day 7	0.3	0.3	0.8	0.9	-0.5	0.7	-0.2	0.0
Stereotopy head waving duration, day 7	0.3	0.4	0.7	0.8	-0.7	0.6	-0.5	-0.3
Locomotion velocity, session 8	0.5	0.6	1.9	1.4	-0.4	0.9	0.0	-0.3
Locomotion distance, session 8	0.4	0.5	1.3	1.2	-0.4	1.1	0.1	-0.1
Degree of sensitization distance	2.3	2.5	5.9	-2.4	1.3	-1.9	1.0	0.6
Degree of sensitization stereotypy	1.1	1.2	2.7	1.7	-1.0	1.4	-0.5	-0.0
Conditioned locomotion	2.5	2.9	3.5	-1.4	1.8	-1.9	1.7	1.6
Cocaine response after cond. corrected	0.1	0.2	0.3	-0.6	-0.4	0.4	-0.3	-0.1
Cocaine response after cond. not corrected	0.1	0.2	0.4	-0.6	-0.4	0.5	-0.3	0.0
Cocaine response before conditioning	0.2	0.2	0.5	-0.4	0.5	-0.7	0.3	0.1
Saline control response	0.6	0.8	1.8	0.8	-0.6	0.7	-0.8	-1.3
Bone: connectivity density	0.8	1.3	4.2	-0.8	0.6	-2.0	0.6	1.1
Bone: cortical apparent density	0.5	0.8	1.5	1.2	-0.9	1.1	-0.7	0.2
Bone: cortical area	0.3	0.5	1.0	-0.5	1.0	0.4	0.9	-0.2
Bone: cortical porosity	0.7	0.8	1.4	-0.9	1.2	-0.9	0.9	0.0
Bone: cortical porosity	0.8	0.9	1.8	-0.7	1.4	-0.8	1.2	0.5
Bone: cortical thickness	2.3	3.8	6.5	-1.8	2.6	-0.9	2.5	1.4
Bone: cortical thickness	0.1	0.1	0.3	0.2	0.5	-0.1	0.6	0.0
Bone: cortical tissue density	0.7	1.1	2.0	1.4	-1.1	1.2	-0.9	0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.3	0.1	-0.3	-0.4	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	-0.0	-0.3	-0.4	-0.1
Condit. Reinf. active responses	0.1	0.1	0.4	0.6	-0.0	-0.4	-0.4	-0.1
Condit. Reinf. inactive responses	0.3	0.4	1.0	1.0	-0.6	0.1	-0.7	-0.6
Incentive salience index mean	0.2	0.3	0.6	0.6	-0.4	0.2	-0.8	-0.6
Condit. Reinf. lever presses	0.7	1.0	1.7	1.1	-1.3	0.7	-1.3	-0.5
Condit. Reinf. active minus inactive responses	0.3	0.4	0.9	-0.1	0.7	0.2	0.9	0.9
Condit. Reinf. active-inactive response ratio	0.5	0.8	2.3	0.1	0.7	0.0	1.0	1.5
Condit. Reinf. active responses	0.2	0.3	0.6	-0.5	0.8	-0.0	0.7	0.1
Condit. Reinf. inactive responses	0.3	0.4	1.8	-0.6	0.1	0.2	-0.1	-1.3
Condit. Reinf. lever presses	0.1	0.1	0.4	-0.6	0.2	0.0	0.1	-0.4
Condit. Reinf. lever reinforcers received	0.2	0.2	0.5	-0.4	0.7	0.0	0.7	0.1
Conditioned reinforcement - actives	0.0	0.1	0.2	-0.4	0.2	-0.3	0.2	0.4
Conditioned reinforcement - inactives	0.1	0.3	0.7	0.1	-0.8	0.3	-0.8	-0.1
Conditioned locomotion	0.2	0.3	0.5	0.4	-0.7	0.6	-0.3	0.3
Patch foraging indifference point 0 sec	0.1	0.3	0.9	0.3	-0.6	0.9	-0.3	0.3
Patch foraging indifference point AUC	0.3	0.7	1.1	0.0	1.0	-0.9	1.0	0.9
Delay disc. indifference point, 0s delay	0.3	0.3	0.9	-0.2	0.8	0.2	1.0	0.4
Delay disc. indifference point, 16s delay	0.5	0.7	1.1	-0.2	0.9	-1.1	0.8	0.9
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	0.2	0.1	0.0	0.3	0.7
Delay disc. indifference point, 24s delay	1.2	1.9	2.7	-1.0	1.3	-1.6	1.3	1.5
Delay disc. indifference point, 4s delay	2.0	2.1	4.7	2.2	-1.5	1.0	-1.4	-0.8
Delay disc. indifference point, 8s delay	0.1	0.2	0.5	0.7	-0.4	-0.1	-0.3	0.1
Indifference point function ln k	0.9	2.9	4.9	1.3	-2.2	1.4	-2.1	-1.1
Indifference point function log k	0.9	2.9	4.9	1.3	-2.2	1.4	-2.1	-1.1
Patch foraging total patch changes 0 sec	0.3	0.8	1.6	0.7	-1.1	1.3	-0.7	0.1
Patch foraging total patch changes 12 sec	0.3	0.5	1.0	-0.3	0.8	0.0	1.0	0.8
Patch foraging total patch changes 18 sec	0.1	0.2	0.4	0.3	0.5	0.0	0.6	0.3
Patch foraging total patch changes 24 sec	0.0	0.2	0.3	-0.1	0.3	-0.5	0.5	0.5
Patch foraging total patch changes 6 sec	0.4	0.6	1.4	1.2	-0.8	0.7	-0.7	-0.4
Patch foraging time to switch 0 sec	0.0	0.1	0.2	-0.2	-0.2	0.2	-0.2	-0.4
Patch foraging water rate 0 sec	0.1	0.3	0.9	1.0	-0.5	0.2	-0.3	0.5
Patch foraging water rate 12 sec	0.1	0.5	1.6	-0.5	0.8	-1.3	0.5	-0.2
Patch foraging water rate 18 sec	0.0	0.1	0.3	-0.3	0.2	-0.5	-0.0	-0.1
Patch foraging water rate 24 sec	0.3	0.5	0.9	-0.2	0.6	-0.9	0.6	0.8
Patch foraging water rate 6 sec	0.6	0.9	1.5	0.9	-1.2	0.9	-1.0	-0.6
Seeking ratio, delayed vs. immediate footshock	2.3	3.3	4.8	-2.2	1.6	-1.7	1.5	2.0
Distance traveled before self-admin	2.1	4.6	6.7	2.4	-1.9	2.6	-1.7	-1.9
Distance traveled after self-admin	5.0	8.8	11.5	2.6	-3.1	3.4	-2.8	-2.7
Extensor digitorum longus weight	4.7	18.8	29.7	5.4	-4.3	4.6	-3.8	-3.3
Bone: elastic displacement	3.1	3.9	6.8	-1.4	1.9	-1.7	2.1	2.6
Bone: elastic work	1.0	1.3	2.3	-0.8	0.9	-1.2	1.1	1.5
Bone: endosteal estimation	1.8	4.3	6.1	1.9	-1.9	2.0	-2.1	-2.5
Bone: endosteal perimeter	1.1	2.7	5.6	1.0	-1.4	2.4	-1.4	-1.7
Epididymis fat weight	0.8	3.9	7.3	2.2	-1.8	2.7	-1.5	-1.3
Delta time in closed arm before/after self-admin	0.4	0.3	1.3	-0.2	0.6	-1.1	0.2	0.1
Delta time in open arm before/after self-admin	0.2	0.2	0.4	-0.5	0.3	0.6	0.5	0.5
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.2	-0.1	-0.0	-0.2	-0.2
Delay discount exponential model param	0.1	0.1	0.3	-0.6	0.1	0.0	0.0	-0.3
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.4	0.2	-0.4	0.3	0.5
Active lever presses in extinction session 6	1.4	1.5	3.8	0.7	-0.7	1.3	-0.8	-2.0
Bone: final force	0.4	0.6	2.1	0.6	-0.0	0.7	-0.4	-1.4
Bone: final moment	0.4	0.6	2.1	0.5	0.0	0.7	-0.3	-1.5
Food consumed during 24 hour testing period	2.7	5.3	6.7	2.6	-2.2	2.2	-2.2	-2.3
Glucose	0.3	0.4	0.8	0.7	-0.3	0.8	-0.3	-0.9
Heart weight	0.4	0.7	1.5	1.2	-0.9	0.2	-0.9	-0.4
Delay discount hyperbolic model param	0.1	0.1	0.5	-0.7	0.2	-0.1	0.1	-0.2
Intermittent access intake day 1-15 change	0.0	0.2	0.9	0.9	-0.3	-0.0	-0.5	-0.2
Intermittent access intake escalation	0.0	0.2	0.9	0.9	-0.3	0.0	-0.5	-0.1
Intermittent access intake escalation 2	0.1	0.2	0.5	0.7	-0.2	-0.1	-0.4	-0.4
Intermitt. access day 1 inactive lever presses	0.1	1.4	2.5	1.1	-1.1	-0.0	-1.5	-1.6
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.3	0.0	-0.1	-0.5	-0.4	-0.5
Intermitt. access escalation Index	0.3	0.9	1.7	-0.6	-0.7	-0.7	-1.2	-1.3
Intermittent access day 1 total infusions	0.0	0.1	0.5	0.2	0.0	-0.7	-0.0	0.5
Intermittent access day 15 total infusions	0.1	0.3	1.1	0.4	0.4	-1.0	0.1	0.3
Intermittent access terminal intake (last 3 days)	0.2	0.4	1.3	1.1	-0.1	-0.7	-0.3	-0.0
Intermittent access total infusions	0.3	0.4	1.5	0.4	0.2	-1.2	-0.0	0.3
Intermittent access day 1 locomotion	0.2	0.3	1.1	0.3	0.3	0.3	0.6	1.0
Intermittent access day 15 total locomotion	0.1	0.3	0.7	0.7	-0.5	0.8	-0.2	0.3
Intermittent access total locomotion	0.2	0.2	0.4	0.6	-0.3	0.5	-0.0	0.6
Intermittent access standard deviation	0.1	0.4	1.1	1.1	-0.5	0.0	-0.7	-0.5
Left kidney weight	0.1	0.5	1.2	0.8	-0.7	1.1	-0.2	0.5
Right kidney weight	0.2	1.1	3.1	1.2	-0.7	1.8	-0.3	-0.1
Cocaine induced anxiety	0.1	0.3	0.6	-0.4	0.8	0.1	0.7	0.2
Post-drug Anxiety	0.3	0.4	0.7	-0.6	0.9	-0.4	0.6	-0.2
Baseline Anxiety	0.3	0.5	0.9	0.6	-0.9	0.0	-0.9	-0.7
Tail length	0.1	0.5	1.0	0.6	-0.8	1.0	-0.7	-0.5
Length with tail	0.4	1.9	3.5	1.1	-1.2	1.9	-1.2	-1.3
Length without tail	0.2	1.0	2.4	1.2	-0.6	1.6	-0.5	-0.7
Times rat made contact with spout	3.7	4.2	7.2	1.2	-1.7	2.6	-1.6	-2.7
Lifetime Intake	0.3	0.4	1.6	0.3	0.4	-1.3	0.1	0.4
Liver weight, left	0.7	1.2	2.0	1.1	-0.8	1.1	-1.1	-1.4
Liver weight, right	5.2	9.0	10.0	2.6	-3.0	3.1	-3.2	-3.2
Locomotor activity	0.4	0.7	1.2	0.7	-0.7	0.9	-0.5	-1.1
Locomotor testing distance	0.3	0.7	1.6	0.4	-0.4	1.2	-0.3	-1.3
Locomotor testing rearing	0.1	0.5	1.0	-1.0	0.7	0.2	0.5	-0.8
Locomotion in novel chamber	0.1	0.2	0.6	0.1	0.2	0.8	0.1	-0.2
Locomotion in novel chamber post-restriction	0.1	0.4	1.3	-0.5	0.7	-1.1	0.2	0.2
Fecal boli incidents, locomotor time 1	0.1	0.3	0.9	-0.1	0.3	-0.7	-0.3	-1.0
Change in fecal boli incidents, locomotor task	3.9	4.1	5.8	-2.2	2.2	-0.9	2.4	2.1
Time >=10cm from walls, locomotor time 1	0.4	0.5	0.9	-1.0	0.9	-0.5	0.6	0.0
Bouts of movement, locomotor time 1	0.2	0.2	0.8	0.2	0.0	-0.4	0.1	0.9
Total resting periods, locomotor time 1	0.3	0.3	1.3	0.2	0.0	-0.4	0.1	1.1
Rest time, locomotor task time 1	0.4	0.6	1.7	1.3	-0.5	0.2	-0.9	-0.6
Distance moved, locomotor task time 1	0.2	0.6	1.0	-1.0	-0.4	0.8	-0.4	-1.0
Vertical activity count, locomotor time 1	0.2	1.3	2.0	-0.2	-1.3	1.2	-1.2	-1.4
Time >=10cm from walls, locomotor time 2	0.6	1.8	3.1	-1.5	1.8	-0.7	1.5	0.9
Bouts of movement, locomotor time 2	0.1	0.4	1.5	0.5	0.2	-0.4	0.4	1.2
Total resting periods, locomotor time 2	0.1	0.4	1.3	0.8	-0.0	-0.3	0.3	1.1
Rest time, locomotor task time 2	0.4	0.6	1.2	1.1	-0.7	-0.3	-0.9	-0.8
Distance moved, locomotor task time 2	0.3	0.4	1.8	-1.4	0.3	0.0	0.1	-0.3
Vertical activity count, locomotor time 2	1.3	3.1	5.0	0.9	-2.0	1.1	-2.2	-2.0
Light reinforcement 1	0.1	0.6	1.8	0.8	-0.6	1.3	-0.2	-0.0
Light reinforcement 2	1.3	3.0	7.8	1.2	-1.9	2.8	-1.2	-0.7
Bone: marrow area	1.9	4.6	6.5	1.9	-2.0	2.0	-2.2	-2.6
Bone: maximum diameter	0.3	0.5	1.5	0.0	0.1	1.1	-0.1	-1.2
Bone: maximum force	0.7	1.5	4.0	1.0	-0.6	1.0	-1.0	-2.0
Bone: maximum moment	0.7	1.2	3.8	0.8	-0.4	1.0	-0.8	-2.0
Mean time between licks in bursts	0.3	1.9	3.8	1.4	-1.5	0.6	-2.0	-0.9
Mean num. licks in bursts	0.0	0.1	0.4	-0.4	0.2	0.0	0.1	-0.6
Cd content in liver	1.1	1.2	1.9	1.4	-0.9	1.0	-1.1	-1.2
Co content in liver	1.8	2.1	4.5	0.7	-1.1	1.6	-1.2	-2.1
Cu content in liver	0.2	0.2	0.7	-0.8	0.5	0.2	0.4	0.0
Fe content in liver	0.4	0.6	1.0	-0.9	1.0	-0.0	0.9	0.1
K content in liver	0.4	0.4	1.0	-1.0	0.4	-0.8	0.4	0.3
Mg content in liver	0.2	0.3	0.6	-0.7	0.2	-0.3	0.3	0.8
Mn content in liver	0.1	0.1	0.2	0.3	-0.1	-0.2	0.0	0.4
Na content in liver	0.1	0.1	0.4	0.2	-0.0	0.6	0.3	0.0
Rb content in liver	1.3	1.5	2.8	-1.7	1.6	-0.7	1.3	0.3
Se content in liver	0.3	0.4	0.7	-0.6	0.8	-0.3	0.8	0.1
Sr content in liver	0.3	0.3	0.9	-0.4	0.3	-1.0	0.2	0.5
Zn content in liver	0.1	0.1	0.2	-0.1	-0.4	-0.1	-0.5	-0.1
Bone: minimum diameter	0.4	0.9	1.9	0.2	-0.7	1.4	-0.7	-1.1
Time in familiar zone, hab. session 1	0.8	0.9	2.8	-0.3	-0.7	0.2	-1.1	-1.7
Time in novel zone, hab. session 1	0.3	0.4	1.3	0.5	0.1	0.2	0.5	1.1
Total zone transitions, hab. session 1	0.4	0.5	1.5	0.1	0.5	-0.6	0.7	1.2
Total locomotion distance, hab. session 1	0.5	0.8	2.4	0.1	0.7	-0.3	1.0	1.5
Locomotion velocity, hab. session 1	0.4	0.6	2.1	0.3	0.4	-0.1	0.7	1.5
Time in familiar zone, hab. session 2	0.3	0.4	0.7	-0.7	-0.4	0.0	-0.7	-0.9
Time in novel zone, hab. session 2	0.5	0.5	0.8	-0.1	0.8	-0.9	0.9	0.6
Total zone transitions, hab. session 2	0.1	0.1	0.4	0.6	-0.2	0.3	0.2	0.3
Total locomotion distance, hab. session 2	0.2	0.2	0.6	0.0	0.3	-0.1	0.6	0.8
Locomotion velocity, hab. session 2	0.3	0.4	1.1	0.1	0.3	0.1	0.7	1.1
Novel to familiar place preference ratio	2.1	2.7	3.3	-1.3	1.8	-1.7	1.8	1.5
Novelty place preference	1.9	2.4	3.0	-1.2	1.6	-1.6	1.7	1.5
Time in novel zone, NPP test	1.4	1.8	2.2	-1.1	1.4	-1.4	1.5	1.2
Total zone transitions, NPP test	0.1	0.2	0.3	0.1	0.5	-0.4	0.5	0.3
Total locomotion distance, NPP test	0.1	0.1	0.3	-0.1	0.5	-0.1	0.5	0.3
Locomotion velocity, NPP test	0.5	0.7	1.1	-0.6	0.9	-0.6	1.0	0.8
Intraocular pressure	0.4	0.6	1.7	1.3	-0.7	0.7	-0.6	-0.2
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.1	-0.3	0.2	-0.2	-0.1
Delta ambulatory time before/after self-admin	0.2	0.3	0.8	-0.6	0.3	-0.4	0.4	0.9
Parametrial fat weight	1.8	4.3	7.1	2.3	-1.8	2.7	-1.8	-1.7
Pavlov. Cond. lever latency	1.0	1.3	2.6	-0.9	1.4	-0.5	1.6	0.9
Pavlov. Cond. magazine entry latency	1.9	2.4	5.0	1.6	-1.9	0.4	-2.2	-1.0
Pavlov. Cond. change in total contacts	3.6	3.9	5.4	2.2	-2.2	1.5	-2.3	-1.6
Pavlov. Cond. index score	3.0	3.8	6.6	2.0	-2.3	1.1	-2.6	-1.3
Pavlov. Cond. latency score	2.2	2.8	5.0	1.6	-1.9	0.9	-2.2	-1.4
Pavlov. Cond. lever contacts	1.8	2.2	4.3	1.4	-1.9	0.6	-2.1	-0.8
Pavlov. Cond. magazine entry number	3.6	4.5	8.1	-2.2	2.6	-1.0	2.8	1.5
Pavlov. Cond. intertrial magazine entries	1.6	1.9	3.5	-0.8	1.4	-0.9	1.6	1.9
Pavlov. Cond. lever-magazine prob. diff.	4.1	5.1	8.3	2.3	-2.7	1.4	-2.9	-1.6
Pavlov. Cond. response bias	3.6	4.4	7.7	2.3	-2.7	1.1	-2.8	-1.1
Pavlov. Cond. lever latency	0.3	0.4	0.9	1.0	-0.5	-0.7	-0.6	0.3
Pavlov. Cond. magazine entry latency	0.6	0.8	1.4	0.6	-0.9	0.8	-1.0	-1.2
Pavlov. Cond. change in total contacts	0.2	0.6	1.0	-0.9	1.0	0.2	1.0	0.2
Pavlov. Cond. index score	0.2	0.3	1.0	-0.0	-0.3	1.0	-0.2	-0.8
Pavlov. Cond. latency score	0.2	0.3	0.9	-0.0	-0.2	0.9	-0.2	-0.8
Pavlov. Cond. lever contacts	0.3	0.5	1.0	-1.0	0.5	0.7	0.7	-0.3
Pavlov. Cond. magazine entry number	0.3	0.4	1.3	-0.0	0.3	-0.8	0.4	1.1
Pavlov. Cond. intertrial magazine entries	0.3	0.6	1.4	-0.5	0.6	-1.2	0.6	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.5	1.3	0.1	-0.4	1.1	-0.3	-0.8
Pavlov. Cond. response bias	0.2	0.3	0.8	-0.6	0.2	0.9	0.3	-0.6
Time in closed arm before self-admin	0.2	0.3	0.8	0.4	-0.9	-0.1	-0.7	-0.1
Time in closed arm after self-admin	0.7	0.8	1.6	0.1	-0.9	-0.7	-1.3	-1.0
Time in open arm before self-admin	0.3	0.4	0.7	0.4	-0.4	0.8	-0.5	-0.9
Time in open arm after self-admin	0.4	0.5	2.2	0.3	0.1	1.5	0.3	0.0
Bone: periosteal estimation	0.7	1.6	3.4	0.8	-0.7	1.6	-0.9	-1.8
Bone: periosteal perimeter	0.4	0.7	2.7	0.0	-0.1	1.6	-0.1	-1.0
Bone: post-yield work	2.5	4.3	9.6	1.6	-1.7	1.2	-2.2	-3.1
Progressive ratio test 1 active lever presses	0.1	0.2	0.7	0.8	0.2	0.1	0.2	0.6
Progressive ratio test 1 breakpoint	0.1	0.2	0.6	0.8	0.2	0.1	0.2	0.6
Progressive ratio test 1 inactive lever presses	0.2	0.4	1.0	-0.6	0.6	-1.0	0.3	0.7
Progressive ratio test 2 active lever presses	0.5	0.8	2.0	0.2	0.7	-0.8	0.9	1.4
Progressive ratio test 2 breakpoint	0.4	0.6	1.6	0.3	0.5	-0.6	0.7	1.3
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.7	0.3	0.0	-0.8	-0.3	-0.0
Incentive Sensitization - Responses	0.1	0.2	0.6	0.0	-0.1	-0.5	0.1	0.8
Incentive Sensitization - Breakpoint	0.1	0.1	0.5	0.2	-0.2	-0.4	-0.1	0.7
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.1	0.6	-1.0	1.1	-0.8	-0.6
Progressive ratio	0.2	0.5	1.0	-0.7	0.8	-1.0	0.4	-0.6
Food seeking constrained by brief footshock	0.1	0.2	0.3	-0.3	-0.5	-0.3	-0.5	-0.3
Seeking ratio, punishment vs. effort	0.2	0.3	0.7	0.3	-0.8	0.6	-0.5	0.7
Retroperitoneal fat weight	0.6	2.5	5.5	2.3	-1.5	1.7	-1.3	-0.6
Reaction time number correct	0.6	1.9	3.8	-2.0	1.6	-1.3	1.2	0.2
Reaction time mean minus median	1.6	10.3	13.7	3.6	-3.7	2.8	-3.4	-2.2
Reaction time mean minus median AUC	1.4	9.4	13.5	3.7	-3.4	2.4	-3.3	-2.3
Reaction time num false alarms	3.2	5.4	8.0	-2.6	2.8	-2.1	2.4	1.4
Reaction time num false alarms AUC	2.2	5.0	7.4	-2.5	2.7	-1.9	2.3	1.4
Reaction time trials correct on left	0.6	1.9	3.8	-2.0	1.6	-1.3	1.2	0.2
Reaction time trials on left	0.6	1.9	3.8	-1.9	1.6	-1.2	1.2	0.1
Reaction time mean	1.5	3.2	4.4	1.6	-1.9	1.6	-2.1	-1.7
Reaction time mean AUC	1.1	2.8	4.1	1.4	-1.8	1.4	-2.0	-1.6
Median of all reaction times	0.7	1.0	1.7	0.7	-0.9	0.9	-1.3	-1.2
Reaction time omissions	0.8	1.2	1.8	1.0	-1.0	1.0	-1.3	-1.2
Reaction time false alarm rate	1.4	1.9	2.8	-1.3	1.7	-1.0	1.6	1.3
Reaction time premature initiation rate	0.1	0.1	0.3	0.1	-0.2	-0.5	0.0	0.6
Reaction time premature initiations	0.1	0.3	0.8	-0.6	0.3	-0.9	0.4	0.5
Std. dev. reaction times	2.0	6.7	8.0	2.7	-2.8	2.2	-2.8	-2.3
Reaction time trials completed	0.6	1.9	3.8	-1.9	1.6	-1.2	1.2	0.1
Reaction time trials AUC	0.5	1.7	3.3	-1.8	1.6	-1.1	1.2	0.1
Run reversals in cocaine runway, females	4.4	4.9	6.6	2.0	-2.4	2.6	-2.2	-1.8
Run reversals in cocaine runway, males	1.6	1.8	2.6	1.3	-1.3	0.9	-1.5	-1.6
Latency to leave start box in cocaine runway	0.8	1.0	1.9	0.6	-1.3	0.3	-1.4	-1.0
Latency to leave start box in cocaine runway, F	0.5	0.6	1.2	0.5	-0.9	0.1	-1.1	-0.9
Latency to leave start box in cocaine runway, M	0.4	0.4	0.7	0.3	-0.8	0.5	-0.8	-0.6
Std. dev. time between licks in bursts	0.4	0.7	1.7	-0.4	0.7	-0.6	0.8	1.3
Total sessions with >9 infusions	0.8	1.0	1.3	-0.8	1.1	-1.0	1.0	0.9
Short access day 1 total inactive lever presses	0.6	1.2	2.1	-1.1	0.9	-1.0	1.1	1.5
Short access day 10 total inactive lever presses	0.0	0.1	0.5	-0.2	0.0	-0.2	-0.2	-0.7
Short access day 1 total infusions	0.1	0.1	0.4	0.3	0.1	0.1	0.1	0.7
Short access day 10 total infusions	0.1	0.2	0.7	-0.1	0.3	-0.8	0.0	0.2
Short access total infusions	0.3	0.4	1.0	0.0	0.6	-1.0	0.4	0.6
Short access day 1 locomotion	0.7	1.2	3.0	-0.3	0.9	-0.1	1.4	1.7
Short access day 10 total locomotion	0.0	0.1	0.3	0.0	0.5	0.0	0.4	-0.0
Short access total locomotion	0.3	0.4	0.7	0.1	0.7	-0.2	0.8	0.9
One hour access (0.3 mA shock)	0.4	0.5	1.0	0.5	-0.9	-0.2	-1.0	-0.4
Compulsive drug intake	0.2	0.3	0.6	-0.1	-0.7	-0.4	-0.7	-0.7
One hour access (shock baseline)	0.2	0.4	1.2	-0.3	0.7	-1.1	0.3	0.5
Social response proportion	0.0	0.0	0.2	-0.1	0.0	0.4	-0.1	-0.0
Social responses	0.7	0.9	1.7	0.5	-0.8	1.3	-0.8	-1.0
Social time	0.2	0.4	1.2	-0.4	0.3	-0.6	-0.3	-1.1
Soleus weight	0.2	0.5	0.7	0.9	-0.5	0.9	0.3	0.8
Bone: stiffness	1.0	1.8	5.0	0.9	-0.6	1.3	-1.1	-2.2
Tibialis anterior weight	4.7	16.2	28.3	5.3	-4.1	4.3	-3.4	-2.5
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.8	0.1	0.6	-0.1	0.1	-0.9
Time to tail flick, vehicle, after self-admin	2.9	6.0	8.4	-2.0	2.7	-2.3	2.9	2.2
Time to tail flick, test, before self-admin	0.5	0.5	1.0	0.8	-1.0	0.8	-0.5	0.3
Time to tail flick, test, after self-admin	1.2	1.2	2.6	-0.8	1.1	-1.6	1.1	0.6
Delta time to tail flick, vehicle, before/after SA	6.2	6.6	8.2	-2.3	2.4	-2.5	2.9	2.8
Delta time to tail flick, test, before/after SA	0.8	1.0	1.6	-0.6	1.2	-1.3	1.0	0.5
Tibia length	0.1	0.2	0.4	-0.0	0.6	0.0	0.4	-0.5
Ambulatory time before self-admin	1.5	4.6	6.4	2.2	-2.0	2.5	-1.8	-2.1
Ambulatory time after self-admin	2.4	3.9	5.3	1.8	-2.1	2.3	-1.9	-1.7
Bone: tissue strength	0.2	0.2	0.5	-0.1	0.4	-0.3	-0.1	-0.7
Total heroin consumption	0.6	0.8	1.4	0.6	-0.9	1.2	-0.6	-1.0
Bone: trabecular number	0.8	1.5	3.4	-1.0	1.1	-1.8	1.1	0.8
Bone: trabecular spacing	0.1	0.1	0.2	0.1	0.4	0.4	0.3	0.2
Bone: trabecular thickness	0.2	0.3	0.7	-0.6	-0.4	-0.8	-0.4	-0.2
Bone: trabecular tissue density	1.3	2.2	4.4	0.5	-0.8	2.0	-1.3	-2.1
Water consumed over 24 hours	0.4	0.8	2.2	0.5	-0.5	0.9	-0.6	-1.5
Number of responses in last shaping day	0.4	0.5	1.4	-0.1	0.5	0.2	1.0	1.2