Hub : Genes

Creb3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Creb3	0.15	0.1	4.9e-05	0.04	0.01	0.03	0.03	2.9e-04	1.5e-02	1.4e-03	1.7e-03
2	Adipose	mRNA stability	Creb3	0.05	0.04	7.7e-04	0.01	0.02	0.02	0.02	4.9e-02	3.4e-03	1.1e-03	4.5e-03
3	Adipose	gene expression	Creb3	0.04	0.03	2.6e-03	0	0	0	0	3.1e-01	1.0e-01	1.1e-01	1.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.5	1.0	2.0	1.4	0.8	-0.6
Area under the delay curve	0.1	0.1	0.4	-0.6	-0.1	0.1
BMI with tail	1.0	3.6	4.7	2.2	1.7	-1.7
BMI without tail	0.9	4.8	6.9	2.6	2.1	-1.8
Body weight	3.5	15.3	16.5	4.1	4.1	-3.6
Weight adjusted by age	0.2	0.7	1.0	0.6	0.9	-1.0
Bone surface	0.7	1.3	1.7	1.3	1.2	-1.0
Bone volume	0.3	0.7	1.0	1.0	0.8	-0.6
Breakpoint value in progressive ratio session	1.1	1.9	3.1	-0.4	1.6	-1.8
Number of licking bursts	1.0	3.1	5.5	2.3	1.6	-1.2
Context. condit. distance diff. score	0.1	0.1	0.2	-0.4	-0.4	0.3
Locomotion velocity, session 1	5.0	5.6	7.7	1.2	2.8	-2.8
Locomotion distance, session 1	1.4	1.8	2.4	0.9	1.6	-1.4
Locomotion velocity, session 2	1.1	1.3	2.9	1.7	0.9	-0.6
Locomotion distance, session 2	2.2	3.1	4.0	2.0	1.9	-1.3
Locomotion velocity, session 3	0.8	0.9	1.3	0.4	1.2	-1.1
Locomotion distance, session 3	4.0	4.6	5.2	1.8	2.3	-2.3
Stereotopy head waving bouts, day 3	0.2	0.3	0.4	-0.1	0.6	-0.7
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.5	0.0	-0.0
Locomotion velocity, session 7	0.1	0.1	0.1	-0.3	-0.2	0.2
Locomotion distance, session 7	0.5	0.6	0.8	0.6	0.9	-0.8
Stereotopy head waving bouts, day 7	2.0	2.3	3.0	1.3	1.6	-1.7
Stereotopy head waving duration, day 7	0.7	0.9	0.9	0.9	1.0	-0.9
Locomotion velocity, session 8	0.1	0.2	0.4	0.2	0.6	-0.3
Locomotion distance, session 8	0.5	0.7	0.9	0.7	1.0	-0.8
Degree of sensitization distance	1.7	1.8	2.2	-1.2	-1.3	1.5
Degree of sensitization stereotypy	1.6	1.7	2.1	1.2	1.2	-1.4
Conditioned locomotion	0.6	0.7	1.4	-0.1	0.9	-1.2
Cocaine response after cond. corrected	0.4	0.7	1.9	-1.4	-0.0	-0.3
Cocaine response after cond. not corrected	0.3	0.5	1.3	-1.1	0.2	-0.2
Cocaine response before conditioning	0.3	0.4	0.9	0.9	0.5	-0.1
Saline control response	1.5	2.1	2.8	1.3	1.7	-1.4
Bone: connectivity density	0.2	0.4	0.9	0.9	0.3	-0.3
Bone: cortical apparent density	0.6	0.9	1.3	-0.3	-1.1	1.2
Bone: cortical area	0.6	1.0	2.6	1.6	0.5	-0.2
Bone: cortical porosity	0.2	0.2	0.2	-0.4	-0.5	0.4
Bone: cortical porosity	0.0	0.1	0.1	0.1	0.3	-0.3
Bone: cortical thickness	0.2	0.3	0.3	0.5	-0.5	0.5
Bone: cortical thickness	0.9	1.1	1.4	-0.9	-1.2	1.1
Bone: cortical tissue density	0.5	0.9	1.2	-0.3	-1.1	1.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.7	0.8	0.2	-0.1
Condit. Reinf. active-inactive response ratio	0.8	0.8	0.9	-0.9	-1.0	0.9
Condit. Reinf. active responses	1.4	1.9	4.1	2.0	1.0	-0.6
Condit. Reinf. inactive responses	1.5	1.9	4.6	2.1	1.0	-0.5
Incentive salience index mean	3.3	4.3	6.9	2.6	1.9	-1.5
Condit. Reinf. lever presses	9.5	14.3	18.6	4.3	3.8	-3.1
Condit. Reinf. active minus inactive responses	0.2	0.4	0.9	0.9	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.3	-0.2	0.1
Condit. Reinf. active responses	1.4	1.9	3.7	1.9	1.1	-1.0
Condit. Reinf. inactive responses	1.2	1.7	3.8	1.9	1.0	-0.7
Condit. Reinf. lever presses	0.8	1.1	3.2	1.8	0.3	-0.1
Condit. Reinf. lever reinforcers received	1.5	2.2	4.2	2.0	1.2	-0.9
Conditioned reinforcement - actives	0.1	0.4	0.7	0.1	0.6	-0.8
Conditioned reinforcement - inactives	0.1	0.2	0.4	-0.7	0.2	-0.3
Conditioned locomotion	0.8	1.2	2.1	0.3	1.1	-1.5
Patch foraging indifference point 0 sec	1.9	5.4	8.5	1.0	2.6	-2.9
Patch foraging indifference point AUC	4.5	10.8	14.9	3.9	3.3	-2.6
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	-0.8	-0.1	0.2
Delay disc. indifference point, 16s delay	0.3	0.4	0.7	-0.8	0.3	-0.5
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	0.1	-0.2	0.3
Delay disc. indifference point, 24s delay	0.1	0.2	0.2	-0.4	-0.3	0.5
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	-0.2	-0.2	0.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	0.1	0.0	0.1
Indifference point function ln k	1.0	3.1	5.2	-2.3	-1.6	1.2
Indifference point function log k	1.0	3.1	5.2	-2.3	-1.6	1.2
Patch foraging total patch changes 0 sec	2.1	6.3	9.4	1.3	2.8	-3.1
Patch foraging total patch changes 12 sec	2.6	3.5	3.6	1.9	1.9	-1.8
Patch foraging total patch changes 18 sec	0.7	1.6	1.9	1.3	1.4	-1.1
Patch foraging total patch changes 24 sec	1.4	4.9	5.0	2.2	2.2	-2.2
Patch foraging total patch changes 6 sec	4.9	8.3	9.7	2.3	3.1	-3.1
Patch foraging time to switch 0 sec	1.6	6.1	6.2	-2.5	-2.5	2.4
Patch foraging water rate 0 sec	1.5	5.8	8.2	1.9	2.4	-2.9
Patch foraging water rate 12 sec	0.0	0.2	0.5	0.0	0.2	-0.7
Patch foraging water rate 18 sec	0.1	0.2	0.3	0.5	0.0	-0.5
Patch foraging water rate 24 sec	0.3	0.4	0.7	-0.3	-0.9	0.6
Patch foraging water rate 6 sec	0.4	0.6	0.9	0.9	0.6	-0.8
Seeking ratio, delayed vs. immediate footshock	2.0	2.8	3.5	1.9	1.6	-1.6
Distance traveled before self-admin	2.0	4.5	5.5	2.4	2.0	-2.0
Distance traveled after self-admin	0.2	0.4	1.0	1.0	-0.1	0.3
Extensor digitorum longus weight	4.4	17.4	23.2	4.8	4.1	-3.5
Bone: elastic displacement	5.0	6.3	7.7	-2.8	-2.6	2.1
Bone: elastic work	5.0	6.5	8.5	-2.1	-2.9	2.5
Bone: endosteal estimation	1.3	3.2	3.9	2.0	2.0	-1.4
Bone: endosteal perimeter	1.5	3.6	4.3	1.9	2.1	-1.7
Epididymis fat weight	0.1	0.6	1.4	1.2	0.6	-0.2
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.2	-0.4	0.6
Delta time in open arm before/after self-admin	0.1	0.1	0.1	-0.3	0.2	-0.3
Diff in mean of infusions in LGA sessions	0.4	0.8	1.4	-0.5	-0.8	1.2
Delay discount exponential model param	0.1	0.1	0.3	0.5	0.1	0.0
Extinction: sum of active levers before priming	1.4	2.2	4.1	-2.0	-1.2	1.0
Active lever presses in extinction session 6	0.1	0.1	0.4	-0.6	-0.2	-0.0
Bone: final force	0.7	1.1	2.5	1.6	0.8	-0.2
Bone: final moment	0.4	0.7	1.9	1.4	0.5	0.1
Food consumed during 24 hour testing period	0.4	0.8	1.0	1.0	1.0	-0.7
Glucose	2.6	4.0	4.7	2.2	2.0	-1.8
Heart weight	0.3	0.6	1.1	1.0	0.7	-0.4
Delay discount hyperbolic model param	0.0	0.1	0.1	0.4	-0.1	0.1
Intermittent access intake day 1-15 change	0.1	0.3	0.7	0.9	0.4	-0.3
Intermittent access intake escalation	0.0	0.2	0.5	0.7	0.1	0.0
Intermittent access intake escalation 2	0.1	0.2	0.5	0.7	-0.2	0.3
Intermitt. access day 1 inactive lever presses	0.1	1.6	1.8	1.4	1.3	-1.1
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.2	0.1	0.3	-0.5
Intermitt. access escalation Index	0.3	0.8	1.1	1.0	1.1	-0.7
Intermittent access day 1 total infusions	0.3	0.9	1.5	-1.2	0.5	-0.9
Intermittent access day 15 total infusions	0.1	0.2	0.4	-0.0	0.5	-0.6
Intermittent access terminal intake (last 3 days)	0.3	0.6	0.8	0.1	0.9	-0.9
Intermittent access total infusions	0.9	1.1	1.8	0.1	1.2	-1.3
Intermittent access day 1 locomotion	0.3	0.6	1.1	-1.0	0.4	-0.8
Intermittent access day 15 total locomotion	0.1	0.5	1.1	-1.1	0.2	-0.7
Intermittent access total locomotion	0.6	0.7	2.0	-1.4	-0.5	0.1
Intermittent access standard deviation	0.1	0.5	0.8	0.4	0.6	-0.9
Left kidney weight	0.5	3.7	4.8	1.9	2.2	-1.7
Right kidney weight	0.2	1.3	2.1	1.4	1.2	-0.5
Cocaine induced anxiety	0.1	0.2	0.2	-0.4	-0.4	0.5
Post-drug Anxiety	0.6	0.6	1.0	1.0	0.9	-0.4
Baseline Anxiety	0.2	0.4	0.9	0.9	0.5	-0.1
Tail length	1.0	5.6	9.3	3.0	2.3	-1.5
Length with tail	2.1	9.4	11.2	3.1	3.4	-2.8
Length without tail	0.3	1.7	2.6	0.6	1.5	-1.6
Times rat made contact with spout	0.1	0.1	0.3	0.5	0.2	-0.1
Lifetime Intake	1.3	1.7	2.7	0.1	1.5	-1.7
Liver weight, left	0.0	0.0	0.0	-0.1	0.1	0.2
Liver weight, right	0.8	1.4	1.7	-1.3	-1.3	1.0
Locomotor activity	0.0	0.0	0.0	0.2	0.0	0.1
Locomotor testing distance	0.0	0.1	0.1	-0.1	0.4	-0.3
Locomotor testing rearing	0.3	1.1	1.5	1.2	1.2	-0.6
Locomotion in novel chamber	0.6	0.8	1.0	-0.7	-1.0	1.0
Locomotion in novel chamber post-restriction	0.2	0.5	1.0	1.0	-0.2	0.6
Fecal boli incidents, locomotor time 1	0.4	1.1	1.2	-1.0	-1.1	1.1
Change in fecal boli incidents, locomotor task	1.7	1.8	2.1	1.0	1.4	-1.5
Time >=10cm from walls, locomotor time 1	0.6	0.8	1.3	0.4	0.9	-1.1
Bouts of movement, locomotor time 1	1.5	1.9	2.4	-1.5	-1.4	1.2
Total resting periods, locomotor time 1	2.8	3.3	3.6	-1.8	-1.9	1.7
Rest time, locomotor task time 1	3.7	5.9	8.0	-1.6	-2.7	2.8
Distance moved, locomotor task time 1	2.0	5.6	6.6	1.9	2.6	-2.6
Vertical activity count, locomotor time 1	0.7	4.9	6.2	1.7	2.5	-2.4
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	0.4	0.3	-0.4
Bouts of movement, locomotor time 2	0.1	0.4	0.6	0.8	0.5	-0.7
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.4	0.2	-0.4
Rest time, locomotor task time 2	0.7	1.2	1.5	-1.0	-1.2	1.0
Distance moved, locomotor task time 2	0.1	0.2	0.4	0.6	-0.0	0.4
Vertical activity count, locomotor time 2	0.3	0.6	1.1	1.0	0.8	-0.4
Light reinforcement 1	1.1	5.2	7.0	1.6	2.6	-2.4
Light reinforcement 2	2.0	4.6	7.1	1.1	2.7	-2.3
Bone: marrow area	1.2	3.0	4.0	2.0	1.8	-1.3
Bone: maximum diameter	1.1	2.3	4.6	2.1	1.3	-0.7
Bone: maximum force	1.3	2.6	5.7	2.4	1.3	-0.6
Bone: maximum moment	1.0	1.8	4.4	2.1	0.9	-0.3
Mean time between licks in bursts	0.2	1.3	2.2	-0.7	-1.1	1.5
Mean num. licks in bursts	0.7	2.0	2.7	-1.6	-1.4	1.2
Cd content in liver	0.7	0.8	1.0	1.0	1.0	-0.6
Co content in liver	0.1	0.1	0.2	-0.4	-0.0	-0.0
Cu content in liver	2.3	2.7	2.8	-1.6	-1.7	1.7
Fe content in liver	0.3	0.3	0.8	-0.9	-0.3	0.3
K content in liver	0.0	0.0	0.1	-0.2	0.2	-0.3
Mg content in liver	0.2	0.2	0.4	-0.7	-0.3	0.1
Mn content in liver	0.3	0.3	0.9	0.9	0.3	0.0
Na content in liver	2.2	2.5	3.3	-1.3	-1.6	1.8
Rb content in liver	3.8	4.5	6.5	-2.6	-2.0	1.7
Se content in liver	0.7	0.9	2.0	1.4	0.7	-0.3
Sr content in liver	0.4	0.4	0.5	0.6	0.7	-0.5
Zn content in liver	0.1	0.1	0.3	0.3	-0.2	0.5
Bone: minimum diameter	0.1	0.2	0.3	-0.2	-0.5	0.5
Time in familiar zone, hab. session 1	2.0	2.2	3.4	-1.0	-1.8	1.5
Time in novel zone, hab. session 1	0.2	0.2	0.6	-0.8	0.3	-0.1
Total zone transitions, hab. session 1	0.0	0.0	0.1	0.1	-0.1	0.3
Total locomotion distance, hab. session 1	0.3	0.4	0.7	0.5	-0.5	0.8
Locomotion velocity, hab. session 1	0.5	0.7	2.1	1.4	0.3	0.1
Time in familiar zone, hab. session 2	2.2	2.5	3.4	-1.1	-1.8	1.7
Time in novel zone, hab. session 2	0.4	0.4	0.7	-0.8	0.4	-0.5
Total zone transitions, hab. session 2	1.0	1.3	1.5	1.1	1.2	-1.0
Total locomotion distance, hab. session 2	0.6	0.7	1.4	1.2	0.7	-0.5
Locomotion velocity, hab. session 2	0.7	1.0	1.8	1.4	0.8	-0.6
Novel to familiar place preference ratio	0.8	1.1	2.8	-1.7	-0.6	0.3
Novelty place preference	1.5	1.9	4.2	-2.1	-1.0	0.6
Time in novel zone, NPP test	2.0	2.4	5.3	-2.3	-1.2	0.7
Total zone transitions, NPP test	1.1	1.7	2.1	1.3	1.4	-1.1
Total locomotion distance, NPP test	2.7	3.8	4.1	2.0	2.0	-1.8
Locomotion velocity, NPP test	3.1	4.4	5.0	2.2	2.1	-1.9
Intraocular pressure	3.4	5.5	6.6	2.2	2.6	-2.3
Delta distance traveled before/after self-admin	0.7	0.7	1.2	-0.4	-0.9	1.1
Delta ambulatory time before/after self-admin	1.1	1.9	2.6	-1.0	-1.5	1.6
Parametrial fat weight	0.0	0.0	0.1	-0.3	0.1	-0.2
Pavlov. Cond. lever latency	6.1	7.7	10.4	-3.2	-2.7	2.2
Pavlov. Cond. magazine entry latency	0.3	0.3	0.8	0.9	0.4	-0.1
Pavlov. Cond. change in total contacts	2.7	2.9	3.9	2.0	1.7	-1.4
Pavlov. Cond. index score	2.2	2.7	4.9	2.2	1.5	-1.0
Pavlov. Cond. latency score	2.1	2.7	4.6	2.1	1.5	-1.1
Pavlov. Cond. lever contacts	5.4	6.5	9.1	3.0	2.5	-2.0
Pavlov. Cond. magazine entry number	0.3	0.4	0.9	-1.0	-0.4	0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	0.6	0.3	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.3	4.6	2.2	1.3	-0.8
Pavlov. Cond. response bias	2.9	3.6	5.9	2.4	1.8	-1.3
Pavlov. Cond. lever latency	0.8	1.2	3.3	-1.8	-0.4	0.1
Pavlov. Cond. magazine entry latency	0.9	1.2	1.9	-0.6	-1.2	1.4
Pavlov. Cond. change in total contacts	0.4	1.0	1.6	0.7	-1.0	1.3
Pavlov. Cond. index score	0.5	0.7	1.3	0.3	-0.9	1.1
Pavlov. Cond. latency score	0.4	0.7	1.1	0.4	-0.8	1.0
Pavlov. Cond. lever contacts	0.6	0.9	2.5	1.6	0.2	0.1
Pavlov. Cond. magazine entry number	0.9	1.2	2.0	0.0	1.2	-1.4
Pavlov. Cond. intertrial magazine entries	0.4	0.9	1.1	0.7	1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	1.6	0.3	-1.0	1.3
Pavlov. Cond. response bias	0.4	0.5	0.8	0.9	-0.5	0.8
Time in closed arm before self-admin	0.1	0.2	0.5	-0.7	-0.4	0.0
Time in closed arm after self-admin	1.0	1.1	1.3	-0.8	-1.1	1.1
Time in open arm before self-admin	1.6	2.0	2.5	1.4	1.6	-1.2
Time in open arm after self-admin	2.4	2.7	3.3	1.4	1.8	-1.7
Bone: periosteal estimation	0.9	2.3	4.1	2.0	1.4	-0.8
Bone: periosteal perimeter	0.6	1.1	1.4	1.1	1.2	-0.9
Bone: post-yield work	2.3	3.9	5.1	2.3	2.1	-1.5
Progressive ratio test 1 active lever presses	0.8	1.5	2.7	-0.6	1.2	-1.6
Progressive ratio test 1 breakpoint	0.8	1.4	2.5	-0.5	1.2	-1.6
Progressive ratio test 1 inactive lever presses	1.5	3.9	5.3	1.2	2.3	-2.2
Progressive ratio test 2 active lever presses	0.8	1.1	1.8	-0.7	1.1	-1.4
Progressive ratio test 2 breakpoint	0.9	1.1	1.8	-0.7	1.0	-1.3
Progressive ratio test 2 inactive lever presses	0.3	0.9	1.4	0.3	1.2	-1.1
Incentive Sensitization - Responses	0.1	0.2	0.2	-0.4	0.3	-0.5
Incentive Sensitization - Breakpoint	0.1	0.2	0.2	-0.5	0.3	-0.5
Sum of active levers in priming session hrs 5-6	0.9	0.9	2.5	-1.6	-0.2	-0.1
Progressive ratio	0.0	0.1	0.1	-0.0	0.4	-0.1
Food seeking constrained by brief footshock	10.9	13.6	14.7	3.5	3.8	-3.8
Seeking ratio, punishment vs. effort	1.3	3.0	3.4	1.9	1.6	-1.7
Retroperitoneal fat weight	0.6	2.8	3.2	-1.5	-1.8	1.7
Reaction time number correct	0.1	0.5	0.9	0.5	0.6	-0.9
Reaction time mean minus median	0.2	1.3	2.9	0.2	-1.0	1.7
Reaction time mean minus median AUC	0.1	0.5	1.0	0.8	-0.2	1.0
Reaction time num false alarms	0.1	0.2	0.4	0.2	-0.2	0.7
Reaction time num false alarms AUC	0.2	0.4	0.7	0.8	0.7	-0.2
Reaction time trials correct on left	0.1	0.5	0.9	0.5	0.6	-0.9
Reaction time trials on left	0.1	0.4	0.7	0.4	0.6	-0.8
Reaction time mean	2.5	5.5	8.2	-1.6	-2.4	2.9
Reaction time mean AUC	2.5	6.1	8.8	-1.8	-2.5	3.0
Median of all reaction times	4.0	6.3	7.9	-2.2	-2.5	2.8
Reaction time omissions	1.4	2.3	3.1	-1.8	-1.2	1.5
Reaction time false alarm rate	0.1	0.2	0.5	-0.1	-0.2	0.7
Reaction time premature initiation rate	2.4	3.7	4.8	-2.2	-2.0	1.5
Reaction time premature initiations	0.6	1.9	2.9	-1.7	-1.4	0.8
Std. dev. reaction times	0.9	3.0	5.6	-0.6	-1.7	2.4
Reaction time trials completed	0.1	0.4	0.7	0.4	0.6	-0.8
Reaction time trials AUC	0.1	0.4	0.7	0.4	0.5	-0.8
Run reversals in cocaine runway, females	0.1	0.2	0.5	0.0	-0.1	0.7
Run reversals in cocaine runway, males	0.0	0.1	0.1	-0.3	-0.2	0.1
Latency to leave start box in cocaine runway	0.2	0.3	0.4	0.7	0.3	-0.5
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	-0.4	0.0	-0.3
Latency to leave start box in cocaine runway, M	1.7	1.6	2.7	1.6	1.1	-1.0
Std. dev. time between licks in bursts	0.3	0.5	0.6	-0.6	-0.7	0.8
Total sessions with >9 infusions	1.2	1.5	2.5	0.2	1.4	-1.6
Short access day 1 total inactive lever presses	1.5	3.0	4.4	1.0	1.9	-2.1
Short access day 10 total inactive lever presses	0.1	0.4	0.7	0.8	0.4	-0.5
Short access day 1 total infusions	1.1	2.2	3.3	0.3	1.8	-1.8
Short access day 10 total infusions	0.9	1.5	2.5	0.0	1.4	-1.6
Short access total infusions	1.2	1.7	2.7	-0.2	1.5	-1.7
Short access day 1 locomotion	0.3	0.5	1.2	-1.1	0.3	-0.4
Short access day 10 total locomotion	0.3	1.3	1.5	-1.2	-1.2	0.9
Short access total locomotion	0.2	0.3	0.4	-0.4	0.5	-0.6
One hour access (0.3 mA shock)	1.4	1.7	2.4	0.6	1.6	-1.5
Compulsive drug intake	0.2	0.3	0.4	0.4	-0.4	0.6
One hour access (shock baseline)	1.0	2.7	4.4	0.3	1.9	-2.1
Social response proportion	3.8	4.8	6.2	-1.7	-2.2	2.5
Social responses	0.4	0.5	1.1	1.1	0.6	-0.1
Social time	0.4	0.6	1.5	-0.2	-0.6	1.2
Soleus weight	0.5	1.6	2.9	0.5	1.7	-1.3
Bone: stiffness	1.7	3.1	7.1	2.7	1.4	-0.5
Tibialis anterior weight	7.6	26.3	32.9	5.7	5.1	-4.4
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.7	-0.8	-0.6	0.4
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.0	-0.1	-0.1
Time to tail flick, test, before self-admin	0.5	0.5	0.7	0.8	0.8	-0.5
Time to tail flick, test, after self-admin	0.6	0.6	1.5	1.2	0.5	-0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.4	0.1	0.1
Delta time to tail flick, test, before/after SA	0.3	0.4	0.6	-0.3	-0.8	0.6
Tibia length	0.1	0.3	0.5	0.4	0.7	-0.4
Ambulatory time before self-admin	1.4	4.2	4.4	2.1	2.0	-2.0
Ambulatory time after self-admin	0.1	0.2	0.6	0.8	0.3	-0.2
Bone: tissue strength	0.3	0.3	0.6	0.5	-0.3	0.8
Total heroin consumption	0.4	0.5	1.0	-1.0	0.3	-0.7
Bone: trabecular number	0.3	0.6	1.5	1.2	0.6	-0.3
Bone: trabecular spacing	0.1	0.1	0.2	-0.1	-0.4	0.4
Bone: trabecular thickness	0.2	0.3	0.3	-0.4	-0.6	0.6
Bone: trabecular tissue density	1.5	2.7	5.4	2.3	1.4	-0.7
Water consumed over 24 hours	0.3	0.6	0.7	0.9	0.7	-0.7
Number of responses in last shaping day	1.6	2.0	3.5	0.1	1.6	-1.9