Hub : Genes

Crb1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye mRNA stability Crb1 0.5 0.18 1.7e-04 0.15 0.16 0.13 0.15 2.9e-03 2.1e-03 4.9e-03 2.5e-03
2 LHb gene expression Crb1 0.64 0.17 8.2e-15 0.44 0.48 0.47 0.48 1.1e-11 4.6e-13 1.1e-12 5.0e-13
3 Brain gene expression Crb1 0.72 0.05 0.0e+00 0.36 0.37 0.37 0.38 8.8e-35 1.3e-35 4.3e-36 2.4e-37
4 Eye intron excision ratio chr13_53407934_53415511 0.3 0.2 6.1e-03 0.1 0.13 0.16 0.08 1.4e-02 4.8e-03 1.7e-03 2.2e-02
5 pVTA gene expression Crb1 0.43 0.14 3.1e-14 0.18 0.17 0.18 0.2 8.1e-15 2.1e-13 8.4e-15 6.6e-16
6 Eye gene expression Crb1 0.84 0.11 9.1e-07 0.14 0.23 0.26 0.24 3.1e-03 2.0e-04 6.3e-05 1.4e-04
7 BLA gene expression Crb1 0.72 0.09 0.0e+00 0.34 0.38 0.38 0.39 1.1e-18 3.3e-21 1.4e-21 5.3e-22
8 IC gene expression Crb1 0.63 0.11 0.0e+00 0.3 0.29 0.29 0.33 2.8e-13 1.6e-12 1.1e-12 1.0e-14
9 PL gene expression Crb1 0.74 0.05 0.0e+00 0.51 0.55 0.58 0.58 3.3e-64 3.4e-72 1.8e-77 8.1e-78
10 NAcc gene expression Crb1 0.64 0.05 0.0e+00 0.39 0.45 0.47 0.46 9.2e-63 3.3e-75 2.9e-80 4.0e-79
11 OFC gene expression Crb1 0.67 0.15 1.0e-07 0.22 0.19 0.19 0.2 6.1e-06 2.7e-05 2.4e-05 1.4e-05
12 IL gene expression Crb1 0.83 0.08 1.4e-12 0.44 0.45 0.48 0.47 9.4e-12 3.9e-12 4.4e-13 5.6e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.52.65.6-2.41.32.30.72.01.92.01.21.41.30.40.8
Area under the delay curve0.30.31.00.3-1.0-0.4-0.9-0.0-0.20.10.60.40.41.00.7
BMI with tail1.86.213.6-3.21.53.70.93.41.33.32.42.62.60.71.7
BMI without tail0.72.05.8-2.42.22.31.11.71.21.30.30.60.6-0.8-0.1
Body weight3.214.131.0-4.82.05.61.35.22.74.93.43.93.81.82.6
Weight adjusted by age0.40.71.5-0.10.9-0.2-0.1-0.7-0.5-0.6-1.2-1.0-1.0-1.2-1.1
Bone surface2.34.29.5-3.12.02.91.32.72.22.61.41.71.6-0.00.8
Bone volume1.83.27.4-2.51.52.71.12.41.52.21.41.71.60.20.9
Breakpoint value in progressive ratio session0.10.10.30.3-0.2-0.00.5-0.00.5-0.40.0-0.0-0.3-0.0-0.2
Number of licking bursts0.10.20.8-0.60.50.10.5-0.20.9-0.0-0.3-0.3-0.30.2-0.3
Context. condit. distance diff. score1.51.84.22.0-1.0-2.00.3-2.0-1.3-1.9-0.7-1.0-1.1-0.7-0.7
Locomotion velocity, session 10.40.42.6-0.50.40.91.60.50.40.00.20.20.20.60.3
Locomotion distance, session 10.30.41.7-0.50.70.51.30.11.0-0.1-0.4-0.4-0.5-0.0-0.3
Locomotion velocity, session 20.20.21.0-0.60.80.51.00.20.50.1-0.4-0.2-0.20.0-0.4
Locomotion distance, session 21.31.93.7-0.51.70.21.8-0.30.8-0.9-1.9-1.6-1.7-1.6-1.8
Locomotion velocity, session 30.80.93.80.30.5-0.72.0-1.01.0-0.8-0.7-1.0-0.9-0.7-1.0
Locomotion distance, session 33.63.96.10.01.7-1.62.5-2.11.6-1.6-2.1-2.4-2.3-2.0-2.5
Stereotopy head waving bouts, day 30.10.10.20.5-0.5-0.4-0.3-0.3-0.3-0.30.10.00.0-0.30.1
Stereotopy head waving duration, day 30.70.81.80.7-1.30.3-0.90.5-1.00.51.11.11.10.61.2
Locomotion velocity, session 70.30.32.5-0.20.60.41.60.10.1-0.1-0.2-0.2-0.1-0.8-0.2
Locomotion distance, session 70.81.02.90.20.6-0.71.7-1.10.4-0.9-1.1-1.2-1.1-0.7-1.1
Stereotopy head waving bouts, day 71.21.33.81.7-1.9-0.7-1.4-0.6-2.0-0.30.70.70.60.40.8
Stereotopy head waving duration, day 70.70.83.11.4-1.4-0.5-1.2-0.5-1.8-0.30.30.40.3-0.00.4
Locomotion velocity, session 81.31.64.01.10.0-1.22.0-1.4-0.1-1.8-1.1-1.4-1.5-0.6-1.3
Locomotion distance, session 83.14.69.11.90.3-2.12.0-2.5-0.7-3.0-2.3-2.5-2.6-1.8-2.4
Degree of sensitization distance0.80.81.6-0.4-0.51.0-0.31.2-0.40.71.01.11.01.11.1
Degree of sensitization stereotypy1.21.44.31.8-1.9-0.7-1.5-0.7-2.1-0.40.70.60.50.40.8
Conditioned locomotion1.41.72.8-1.2-0.21.3-1.31.70.81.41.51.61.60.91.3
Cocaine response after cond. corrected0.30.40.80.50.1-0.4-0.4-0.5-0.8-0.7-0.9-0.7-0.7-0.9-0.7
Cocaine response after cond. not corrected1.11.33.10.11.2-0.20.9-0.5-0.1-1.0-1.6-1.4-1.4-1.8-1.5
Cocaine response before conditioning1.31.56.0-0.61.80.32.40.11.0-0.6-1.1-1.1-1.1-1.2-1.3
Saline control response0.70.91.8-0.61.3-0.01.2-0.21.0-0.4-1.2-1.0-1.0-1.1-1.2
Bone: connectivity density2.84.39.1-2.91.62.70.92.73.02.71.51.71.60.61.1
Bone: cortical apparent density0.60.81.20.8-0.1-0.9-0.6-1.0-0.7-1.0-1.1-1.0-1.0-1.0-1.0
Bone: cortical area1.52.45.0-2.21.32.10.81.81.51.91.41.51.5-0.11.0
Bone: cortical porosity3.43.612.0-2.02.90.93.50.33.2-0.1-1.2-1.1-1.2-1.0-1.6
Bone: cortical porosity3.33.611.6-1.62.70.43.4-0.23.1-0.4-1.4-1.5-1.5-1.1-1.8
Bone: cortical thickness0.71.22.3-1.50.61.3-0.11.11.41.41.11.21.20.40.9
Bone: cortical thickness0.60.82.6-1.21.60.70.70.41.20.3-0.6-0.4-0.6-1.0-0.8
Bone: cortical tissue density0.60.81.30.8-0.1-0.9-0.6-1.0-0.6-1.0-1.1-1.0-1.0-0.9-1.0
Condit. Reinf. active minus inactive responses0.30.31.7-0.50.5-0.11.3-0.11.20.0-0.0-0.1-0.1-0.0-0.1
Condit. Reinf. active-inactive response ratio0.90.91.9-0.3-0.80.3-0.50.50.00.91.41.41.31.21.4
Condit. Reinf. active responses1.31.64.8-0.31.3-0.62.2-0.91.4-1.0-1.2-1.3-1.3-1.3-1.3
Condit. Reinf. inactive responses3.03.76.30.21.8-1.02.5-1.51.1-1.9-2.2-2.4-2.4-2.3-2.3
Incentive salience index mean1.01.25.2-1.01.60.22.3-0.11.5-0.2-0.8-0.7-0.8-1.0-0.9
Condit. Reinf. lever presses1.11.54.4-0.31.4-0.22.1-0.70.9-0.9-1.4-1.4-1.4-1.3-1.3
Condit. Reinf. active minus inactive responses3.34.310.2-0.52.6-0.43.2-0.90.6-1.4-2.4-2.2-2.3-3.0-2.5
Condit. Reinf. active-inactive response ratio1.61.84.30.60.9-1.02.1-1.1-0.1-1.3-1.5-1.6-1.5-1.7-1.5
Condit. Reinf. active responses3.24.411.4-1.13.00.13.4-0.51.0-1.2-2.5-2.1-2.2-2.8-2.4
Condit. Reinf. inactive responses1.51.96.1-2.02.51.31.80.81.80.3-1.0-0.5-0.8-1.1-1.1
Condit. Reinf. lever presses2.43.37.6-1.22.70.32.7-0.31.3-0.8-1.9-1.6-1.8-2.5-2.2
Condit. Reinf. lever reinforcers received4.05.612.8-0.83.0-0.33.6-0.90.8-1.6-2.8-2.5-2.6-3.3-2.9
Conditioned reinforcement - actives0.40.72.3-1.31.40.51.50.41.30.3-0.2-0.3-0.2-0.7-0.5
Conditioned reinforcement - inactives1.62.47.6-2.81.82.11.82.11.41.50.80.80.80.00.2
Conditioned locomotion0.20.31.3-0.90.90.21.10.40.70.20.1-0.0-0.0-0.4-0.4
Patch foraging indifference point 0 sec0.10.20.50.7-0.6-0.6-0.3-0.6-0.7-0.4-0.3-0.3-0.30.4-0.1
Patch foraging indifference point AUC0.10.20.50.2-0.6-0.4-0.7-0.1-0.1-0.10.70.20.40.40.4
Delay disc. indifference point, 0s delay2.42.65.10.9-2.20.5-2.20.7-1.91.11.61.71.62.01.9
Delay disc. indifference point, 16s delay0.40.41.10.4-1.0-0.8-0.7-0.5-0.5-0.20.60.30.41.00.8
Delay disc. indifference point, 2s delay1.01.12.6-0.2-1.00.5-0.61.00.61.11.51.21.31.61.3
Delay disc. indifference point, 24s delay0.30.31.00.5-0.8-0.5-1.0-0.4-1.0-0.10.10.10.20.70.4
Delay disc. indifference point, 4s delay0.40.51.00.9-0.7-1.0-0.1-0.90.4-1.0-0.3-0.7-0.70.1-0.3
Delay disc. indifference point, 8s delay0.10.10.3-0.3-0.00.3-0.60.4-0.20.40.10.30.20.10.2
Indifference point function ln k0.71.32.5-0.3-0.90.9-0.71.0-0.21.11.41.51.41.61.5
Indifference point function log k0.71.32.5-0.3-0.90.9-0.71.0-0.21.11.41.51.41.61.5
Patch foraging total patch changes 0 sec0.10.20.40.7-0.3-0.6-0.0-0.7-0.6-0.5-0.5-0.5-0.50.0-0.4
Patch foraging total patch changes 12 sec1.11.52.70.70.3-1.30.9-1.50.2-1.5-1.3-1.6-1.6-0.8-1.5
Patch foraging total patch changes 18 sec0.61.02.21.4-0.7-1.50.1-1.5-1.1-1.2-0.7-0.9-0.7-0.2-0.5
Patch foraging total patch changes 24 sec0.20.41.10.5-0.3-1.0-0.6-1.0-0.5-0.5-0.5-0.5-0.6-0.1-0.4
Patch foraging total patch changes 6 sec0.50.82.41.1-1.4-0.8-1.5-0.6-1.5-0.20.30.30.20.60.5
Patch foraging time to switch 0 sec0.81.53.11.5-0.2-1.40.0-1.8-1.0-1.5-1.5-1.4-1.4-0.6-1.0
Patch foraging water rate 0 sec0.20.50.8-0.3-0.40.6-0.70.7-0.60.70.80.90.90.50.8
Patch foraging water rate 12 sec0.10.10.50.0-0.10.1-0.00.1-0.70.20.30.40.5-0.00.5
Patch foraging water rate 18 sec0.30.51.60.8-1.0-0.6-1.2-0.5-1.3-0.30.30.30.20.60.4
Patch foraging water rate 24 sec0.00.10.2-0.40.50.1-0.10.3-0.10.3-0.3-0.1-0.1-0.1-0.3
Patch foraging water rate 6 sec0.30.41.2-1.10.71.01.00.80.60.50.20.50.40.30.2
Seeking ratio, delayed vs. immediate footshock1.21.44.02.0-1.5-2.0-1.0-1.6-1.1-0.9-0.5-0.7-0.60.1-0.4
Distance traveled before self-admin0.60.81.60.2-1.00.7-0.10.7-1.30.71.01.20.81.00.9
Distance traveled after self-admin1.62.05.5-2.11.62.31.32.11.01.80.00.70.3-0.4-0.3
Extensor digitorum longus weight0.72.66.4-2.42.12.22.31.72.51.10.30.40.30.3-0.3
Bone: elastic displacement0.60.71.71.0-0.1-1.10.7-1.30.0-1.3-0.8-1.1-0.9-0.0-0.7
Bone: elastic work0.60.71.81.2-0.5-1.2-0.3-1.3-0.7-1.2-0.6-0.8-0.7-0.1-0.4
Bone: endosteal estimation0.20.51.70.0-0.40.60.10.7-1.30.40.90.91.00.20.8
Bone: endosteal perimeter1.73.75.9-1.80.12.30.22.30.82.42.32.42.41.22.2
Epididymis fat weight1.34.58.1-2.81.12.70.82.82.12.82.12.32.10.71.4
Delta time in closed arm before/after self-admin0.90.82.50.4-1.3-0.3-0.8-0.2-0.2-0.11.20.60.91.61.3
Delta time in open arm before/after self-admin0.30.30.80.7-0.3-0.40.80.0-0.9-0.3-0.5-0.5-0.4-0.2-0.5
Diff in mean of infusions in LGA sessions0.10.20.5-0.50.40.50.70.20.4-0.30.50.30.2-0.00.3
Delay discount exponential model param0.30.30.9-0.41.00.50.80.20.30.1-0.4-0.2-0.2-0.9-0.6
Extinction: sum of active levers before priming0.20.30.80.8-0.9-0.10.0-0.1-0.9-0.00.10.30.40.70.4
Active lever presses in extinction session 60.10.10.80.2-0.20.1-0.40.4-0.9-0.00.10.30.30.00.1
Bone: final force0.10.20.5-0.60.70.50.40.3-0.00.40.10.20.2-0.7-0.1
Bone: final moment0.10.20.6-0.50.70.40.70.20.10.30.10.10.1-0.8-0.2
Food consumed during 24 hour testing period0.60.92.4-1.50.91.30.51.01.61.00.50.60.50.20.3
Glucose0.91.55.0-0.72.00.40.60.00.2-0.1-1.5-1.0-1.2-2.2-1.7
Heart weight0.50.82.41.3-1.6-0.9-1.2-0.6-1.10.00.50.30.40.70.6
Delay discount hyperbolic model param0.20.30.8-0.30.90.40.80.0-0.0-0.1-0.5-0.3-0.3-0.9-0.6
Intermittent access intake day 1-15 change0.40.94.90.1-0.90.1-2.20.4-0.70.90.70.80.80.81.0
Intermittent access intake escalation0.30.54.2-0.3-0.40.3-2.10.3-0.30.80.40.50.50.40.6
Intermittent access intake escalation 21.61.89.00.6-1.6-0.0-3.00.2-1.70.90.81.01.01.31.3
Intermitt. access day 1 inactive lever presses0.83.29.4-3.12.53.11.52.50.81.60.40.70.5-0.7-0.1
Intermitt. access day 15 inactive lever presses0.81.65.4-2.01.22.30.42.1-0.51.10.80.90.8-0.10.5
Intermitt. access escalation Index0.30.51.3-0.71.11.10.60.8-0.6-0.10.00.30.2-1.10.1
Intermittent access day 1 total infusions0.81.35.7-1.41.70.62.40.51.80.1-0.1-0.3-0.1-0.7-0.6
Intermittent access day 15 total infusions0.30.42.1-1.10.90.30.00.31.50.50.1-0.00.1-0.3-0.2
Intermittent access terminal intake (last 3 days)0.50.71.3-0.7-0.20.5-0.60.70.71.01.20.91.10.90.9
Intermittent access total infusions0.80.93.6-1.61.40.71.10.71.90.60.20.10.2-0.3-0.3
Intermittent access day 1 locomotion1.41.84.6-2.02.11.52.11.21.90.6-0.1-0.1-0.1-1.0-0.6
Intermittent access day 15 total locomotion0.10.21.1-1.00.60.30.10.51.00.30.20.1-0.1-0.1-0.2
Intermittent access total locomotion1.21.43.8-2.01.91.01.61.01.90.5-0.1-0.2-0.3-0.7-0.7
Intermittent access standard deviation0.91.84.0-1.70.61.8-0.71.91.12.01.11.31.30.60.9
Left kidney weight0.31.22.7-1.60.71.6-0.21.31.61.40.80.80.80.60.5
Right kidney weight0.52.36.1-2.51.82.21.11.52.31.60.60.80.70.20.2
Cocaine induced anxiety0.20.21.6-0.20.7-0.11.3-0.20.2-0.2-0.2-0.3-0.3-0.3-0.3
Post-drug Anxiety1.11.12.50.30.8-1.01.6-1.20.6-1.2-1.0-1.2-1.3-1.0-1.1
Baseline Anxiety0.20.20.80.7-0.9-0.7-0.4-0.6-0.2-0.30.1-0.0-0.10.40.2
Tail length0.52.16.1-1.82.51.61.90.91.90.2-1.0-0.6-0.8-1.4-1.2
Length with tail0.83.58.3-2.51.12.91.02.62.12.21.41.71.51.11.1
Length without tail2.78.713.4-2.2-0.93.3-0.83.51.03.63.63.73.63.23.3
Times rat made contact with spout0.30.42.40.7-0.7-0.3-0.7-0.3-1.5-0.5-0.00.00.2-0.10.4
Lifetime Intake0.70.94.4-1.51.40.61.10.52.10.50.2-0.00.1-0.3-0.3
Liver weight, left2.23.68.7-3.02.02.61.32.42.32.21.21.31.50.00.7
Liver weight, right3.05.212.9-3.42.23.61.13.22.72.51.41.71.70.20.8
Locomotor activity0.40.61.6-1.21.31.21.00.80.80.1-0.3-0.1-0.3-0.3-0.6
Locomotor testing distance0.50.92.0-1.20.41.40.11.41.00.90.90.90.80.70.4
Locomotor testing rearing0.20.51.5-0.81.20.30.70.30.70.1-0.5-0.4-0.3-1.1-0.8
Locomotion in novel chamber0.20.30.6-0.70.20.6-0.50.50.30.60.50.50.50.40.6
Locomotion in novel chamber post-restriction0.30.52.60.7-0.4-0.4-0.2-0.6-1.6-0.7-0.6-0.3-0.6-0.4-0.5
Fecal boli incidents, locomotor time 10.91.32.40.50.6-1.10.6-1.40.2-1.4-1.3-1.4-1.6-1.1-1.4
Change in fecal boli incidents, locomotor task0.50.51.70.9-0.6-1.3-0.5-1.0-0.1-0.8-0.7-0.6-0.5-0.2-0.4
Time >=10cm from walls, locomotor time 12.62.79.42.3-1.4-3.1-0.2-2.6-0.9-1.9-1.0-1.4-1.2-0.1-0.8
Bouts of movement, locomotor time 10.91.03.4-1.30.61.90.91.40.21.00.81.10.90.50.6
Total resting periods, locomotor time 10.30.31.2-0.60.41.10.70.7-0.10.30.30.60.40.20.3
Rest time, locomotor task time 10.81.03.81.3-0.7-1.5-0.0-1.7-0.3-1.9-0.5-0.8-0.7-0.1-0.1
Distance moved, locomotor task time 10.20.31.0-0.71.00.40.80.40.10.5-0.5-0.2-0.2-0.8-0.6
Vertical activity count, locomotor time 10.40.92.1-1.41.11.20.81.50.71.30.30.60.4-0.3-0.1
Time >=10cm from walls, locomotor time 20.50.72.41.1-0.8-1.6-0.3-1.4-0.1-1.0-0.4-0.7-0.70.0-0.2
Bouts of movement, locomotor time 21.32.14.1-2.01.12.01.41.92.01.61.01.00.90.40.5
Total resting periods, locomotor time 20.91.63.1-1.70.81.71.41.61.81.41.10.90.90.60.6
Rest time, locomotor task time 21.01.33.81.1-0.5-1.90.2-1.90.5-1.8-0.6-1.2-1.0-0.1-0.4
Distance moved, locomotor task time 20.50.62.6-0.90.71.60.31.2-0.51.00.10.60.5-0.20.2
Vertical activity count, locomotor time 21.62.25.0-1.90.72.2-0.02.10.92.11.21.41.30.70.9
Light reinforcement 11.84.59.22.7-0.7-2.90.2-2.9-1.6-3.0-2.0-2.3-2.1-1.0-1.8
Light reinforcement 21.52.35.02.2-1.0-2.2-0.4-2.2-1.9-1.9-0.9-1.2-1.1-0.9-0.8
Bone: marrow area0.20.51.70.1-0.40.50.20.7-1.30.30.80.90.90.20.8
Bone: maximum diameter2.34.37.4-2.30.52.70.52.61.42.72.32.52.41.12.0
Bone: maximum force0.50.82.8-1.41.71.21.00.80.50.6-0.10.10.1-1.2-0.4
Bone: maximum moment0.40.82.7-1.21.60.91.20.60.60.4-0.2-0.1-0.1-1.2-0.5
Mean time between licks in bursts0.30.83.3-0.20.8-0.11.8-0.31.0-0.4-0.9-1.0-0.9-0.7-1.1
Mean num. licks in bursts0.30.42.80.9-0.7-0.2-0.7-0.0-1.7-0.30.10.20.2-0.50.3
Cd content in liver2.42.66.20.8-2.5-0.1-1.50.3-0.81.02.01.81.82.52.2
Co content in liver1.71.97.11.9-2.7-0.8-1.1-0.6-1.50.21.10.80.91.81.5
Cu content in liver2.63.19.61.8-2.7-1.2-3.1-0.8-2.0-0.11.31.01.12.01.9
Fe content in liver0.40.51.50.9-0.2-0.6-0.5-0.8-1.2-1.0-0.6-0.6-0.5-0.4-0.4
K content in liver1.01.01.7-0.4-0.70.7-1.10.60.21.31.31.21.30.91.3
Mg content in liver0.90.91.6-0.8-0.21.1-0.61.00.31.31.01.11.10.91.1
Mn content in liver0.30.40.6-0.0-0.50.6-0.70.5-0.30.70.70.80.80.70.7
Na content in liver0.30.31.80.5-0.3-0.5-1.3-0.6-1.1-0.30.0-0.0-0.0-0.5-0.0
Rb content in liver2.22.54.8-0.7-1.01.3-1.61.30.51.62.22.02.01.82.1
Se content in liver2.02.44.7-0.1-1.30.7-1.60.9-0.61.32.12.02.02.02.2
Sr content in liver2.21.94.10.6-1.9-0.1-2.00.5-1.60.91.41.41.41.71.6
Zn content in liver2.62.96.7-0.0-1.80.5-1.91.0-0.31.42.22.02.02.62.3
Bone: minimum diameter0.30.51.1-0.80.20.90.10.9-0.20.70.91.01.0-0.10.7
Time in familiar zone, hab. session 10.30.31.60.4-0.3-0.71.3-0.70.9-0.30.0-0.3-0.30.0-0.1
Time in novel zone, hab. session 10.20.21.00.20.20.1-0.8-0.0-1.0-0.5-0.6-0.4-0.5-0.1-0.5
Total zone transitions, hab. session 10.81.13.9-0.11.0-0.22.0-0.50.5-1.0-1.2-1.2-1.3-0.7-1.2
Total locomotion distance, hab. session 10.50.72.6-0.41.10.71.60.30.5-0.3-0.9-0.7-0.8-1.0-1.0
Locomotion velocity, hab. session 10.81.13.7-0.71.50.91.90.50.7-0.2-1.1-0.8-0.9-1.4-1.2
Time in familiar zone, hab. session 20.40.51.8-0.81.20.30.40.30.1-0.0-0.6-0.4-0.4-1.3-0.8
Time in novel zone, hab. session 21.81.95.50.7-1.90.2-1.20.4-0.50.61.61.41.42.31.9
Total zone transitions, hab. session 23.34.27.50.51.5-1.12.4-1.70.6-2.0-2.7-2.7-2.7-2.2-2.7
Total locomotion distance, hab. session 23.64.89.00.21.9-0.72.6-1.41.0-1.9-3.0-2.8-2.8-2.5-2.9
Locomotion velocity, hab. session 23.95.29.60.12.1-0.62.9-1.31.1-1.9-3.1-2.9-2.9-2.6-3.0
Novel to familiar place preference ratio1.61.73.61.9-0.8-1.70.1-1.8-1.3-1.8-1.1-1.2-1.3-0.2-0.9
Novelty place preference1.51.63.61.9-0.8-1.60.2-1.7-1.3-1.8-1.0-1.2-1.2-0.1-0.8
Time in novel zone, NPP test1.41.54.02.0-1.2-1.6-0.1-1.6-1.5-1.7-0.7-0.9-1.00.1-0.5
Total zone transitions, NPP test2.13.05.50.21.3-0.52.4-1.30.5-1.6-2.3-2.1-2.3-1.9-2.3
Total locomotion distance, NPP test2.73.86.50.11.8-0.42.4-1.20.5-2.0-2.5-2.4-2.5-2.3-2.5
Locomotion velocity, NPP test3.14.47.80.02.0-0.62.6-1.40.6-2.1-2.8-2.6-2.7-2.4-2.8
Intraocular pressure0.00.10.2-0.1-0.1-0.2-0.20.00.40.20.30.20.4-0.00.2
Delta distance traveled before/after self-admin2.12.27.1-1.92.71.41.41.01.40.6-1.3-0.7-0.8-1.8-1.4
Delta ambulatory time before/after self-admin1.82.26.9-2.02.61.31.51.01.80.6-1.2-0.7-0.9-1.7-1.4
Parametrial fat weight2.96.813.2-3.61.53.60.93.42.73.22.42.32.51.61.9
Pavlov. Cond. lever latency2.02.54.8-0.3-1.21.1-1.11.4-0.51.42.22.12.11.92.0
Pavlov. Cond. magazine entry latency0.20.20.90.3-0.5-0.6-1.0-0.1-0.8-0.10.10.20.20.00.3
Pavlov. Cond. change in total contacts0.50.50.90.30.3-0.90.4-0.8-0.5-0.9-0.9-0.9-0.8-0.9-0.7
Pavlov. Cond. index score1.01.22.20.60.5-1.30.2-1.2-0.4-1.2-1.5-1.4-1.4-1.4-1.2
Pavlov. Cond. latency score1.01.22.40.40.6-1.10.3-1.1-0.2-1.2-1.5-1.4-1.4-1.4-1.3
Pavlov. Cond. lever contacts1.21.53.10.50.7-1.00.4-1.2-0.3-1.3-1.8-1.6-1.6-1.5-1.5
Pavlov. Cond. magazine entry number0.30.31.0-0.3-0.11.00.20.70.60.60.60.50.50.80.4
Pavlov. Cond. intertrial magazine entries0.40.53.7-0.10.60.11.9-0.40.9-0.5-0.3-0.5-0.3-0.3-0.2
Pavlov. Cond. lever-magazine prob. diff.1.11.32.40.60.6-1.30.3-1.2-0.5-1.3-1.5-1.5-1.4-1.5-1.3
Pavlov. Cond. response bias0.60.71.30.20.6-0.90.5-0.8-0.0-0.8-1.1-1.1-1.0-1.2-1.0
Pavlov. Cond. lever latency1.82.55.20.6-2.00.0-2.30.6-0.81.21.81.71.82.02.1
Pavlov. Cond. magazine entry latency0.50.61.6-0.00.8-0.30.4-0.6-0.5-1.0-0.9-0.8-0.9-1.3-1.0
Pavlov. Cond. change in total contacts1.32.15.3-0.31.6-0.52.3-0.80.8-1.1-1.5-1.5-1.6-2.1-1.8
Pavlov. Cond. index score1.31.74.3-0.51.7-0.11.7-0.40.4-1.1-1.5-1.3-1.5-2.1-1.8
Pavlov. Cond. latency score1.51.95.0-0.51.8-0.11.6-0.50.4-1.2-1.6-1.4-1.5-2.2-1.9
Pavlov. Cond. lever contacts2.53.56.5-0.72.4-0.12.5-0.71.0-1.4-2.2-2.0-2.1-2.5-2.6
Pavlov. Cond. magazine entry number0.81.02.9-0.2-0.80.6-0.60.80.71.31.11.01.11.71.3
Pavlov. Cond. intertrial magazine entries0.20.30.90.6-0.9-0.5-0.1-0.20.20.20.50.30.50.90.7
Pavlov. Cond. lever-magazine prob. diff.1.01.33.6-0.31.4-0.11.4-0.40.2-1.1-1.2-1.1-1.3-1.9-1.5
Pavlov. Cond. response bias1.92.64.9-0.21.8-0.51.9-0.90.4-1.6-2.0-1.9-2.0-2.1-2.2
Time in closed arm before self-admin0.50.62.21.4-1.3-0.1-1.2-0.4-1.5-0.20.00.30.10.10.4
Time in closed arm after self-admin1.71.85.21.4-2.3-0.3-1.9-0.4-1.00.11.30.91.21.71.6
Time in open arm before self-admin1.51.75.4-2.12.11.11.41.02.30.6-0.00.0-0.0-0.6-0.5
Time in open arm after self-admin1.51.76.1-0.91.90.32.50.50.6-0.4-1.3-1.0-1.2-1.4-1.6
Bone: periosteal estimation0.71.52.8-1.30.41.70.51.60.11.51.41.51.60.21.2
Bone: periosteal perimeter1.72.94.8-1.90.52.10.32.01.32.22.02.02.00.61.7
Bone: post-yield work0.20.41.0-1.00.81.00.10.90.30.60.20.40.2-0.50.1
Progressive ratio test 1 active lever presses2.63.39.1-3.02.91.92.11.62.91.10.30.20.2-1.1-0.4
Progressive ratio test 1 breakpoint2.73.39.3-3.02.92.02.11.72.91.20.30.30.3-1.0-0.4
Progressive ratio test 1 inactive lever presses1.41.95.4-2.21.42.30.92.20.61.50.91.01.10.10.4
Progressive ratio test 2 active lever presses0.80.94.0-1.61.50.60.80.42.00.50.1-0.0-0.1-0.6-0.4
Progressive ratio test 2 breakpoint0.80.94.3-1.61.50.60.70.32.10.5-0.1-0.1-0.2-0.7-0.5
Progressive ratio test 2 inactive lever presses0.71.13.4-1.81.31.50.81.40.51.00.60.70.7-0.30.1
Incentive Sensitization - Responses0.20.30.7-0.10.3-0.7-0.1-0.90.8-0.3-0.6-0.7-0.7-0.5-0.7
Incentive Sensitization - Breakpoint0.30.30.7-0.10.3-0.7-0.1-0.80.7-0.3-0.6-0.7-0.7-0.5-0.6
Sum of active levers in priming session hrs 5-60.20.10.40.10.30.60.10.2-0.5-0.0-0.5-0.1-0.3-0.6-0.4
Progressive ratio0.20.21.8-0.60.40.1-1.40.10.40.7-0.1-0.0-0.1-0.1-0.3
Food seeking constrained by brief footshock2.53.16.70.0-2.00.4-0.91.3-0.41.12.62.12.32.52.4
Seeking ratio, punishment vs. effort0.30.41.30.3-0.70.11.20.4-0.2-0.30.90.60.80.80.8
Retroperitoneal fat weight2.18.820.0-4.53.04.12.64.03.43.32.02.32.1-0.20.9
Reaction time number correct0.30.62.00.10.9-0.10.9-0.4-1.1-0.9-0.8-0.6-0.5-1.4-0.7
Reaction time mean minus median0.51.23.7-1.01.90.41.20.11.2-0.1-1.1-0.9-0.9-1.7-1.2
Reaction time mean minus median AUC0.51.23.8-1.22.00.91.20.61.10.3-0.8-0.6-0.6-1.7-1.0
Reaction time num false alarms0.60.93.4-1.21.50.5-0.00.20.80.3-0.9-0.5-0.6-1.8-1.1
Reaction time num false alarms AUC1.01.54.6-1.42.00.60.40.21.20.3-1.3-0.8-1.0-2.1-1.4
Reaction time trials correct on left0.30.62.00.10.9-0.10.9-0.4-1.1-0.9-0.8-0.6-0.5-1.4-0.7
Reaction time trials on left0.40.72.20.11.0-0.10.9-0.4-1.0-0.9-0.9-0.7-0.5-1.5-0.8
Reaction time mean0.71.22.5-1.10.11.0-0.51.21.51.61.21.01.10.91.0
Reaction time mean AUC0.61.02.1-1.00.00.9-0.41.11.41.41.11.01.00.70.9
Median of all reaction times1.31.93.3-1.0-0.51.0-0.91.31.51.81.71.51.51.61.5
Reaction time omissions1.62.46.8-2.02.61.41.71.12.00.6-0.9-0.6-0.5-2.1-1.1
Reaction time false alarm rate0.50.72.0-1.21.20.50.00.31.40.5-0.7-0.4-0.6-1.1-0.9
Reaction time premature initiation rate1.01.34.7-0.61.3-0.31.6-0.42.2-0.6-1.0-1.3-1.2-0.8-1.2
Reaction time premature initiations0.81.43.0-0.61.6-0.21.7-0.41.3-0.7-1.2-1.3-1.1-1.4-1.3
Std. dev. reaction times0.81.44.3-1.62.11.00.90.81.80.7-0.8-0.6-0.6-1.3-0.9
Reaction time trials completed0.40.72.20.11.0-0.10.9-0.4-1.0-0.9-0.9-0.7-0.5-1.5-0.8
Reaction time trials AUC0.40.72.3-0.11.1-0.00.9-0.3-0.8-0.8-0.9-0.7-0.5-1.5-0.8
Run reversals in cocaine runway, females0.80.82.3-1.00.20.2-0.90.91.41.50.70.81.10.60.6
Run reversals in cocaine runway, males0.90.93.0-0.81.3-0.01.1-0.11.40.0-0.6-0.8-0.7-1.7-0.9
Latency to leave start box in cocaine runway0.40.41.30.8-0.5-1.1-0.2-0.90.7-0.4-0.5-0.7-0.60.1-0.4
Latency to leave start box in cocaine runway, F0.30.40.90.6-0.3-1.0-0.5-0.80.6-0.1-0.7-0.6-0.6-0.2-0.6
Latency to leave start box in cocaine runway, M0.30.30.50.4-0.1-0.70.7-0.60.4-0.7-0.3-0.7-0.7-0.1-0.4
Std. dev. time between licks in bursts0.91.23.6-1.71.61.91.11.60.90.7-0.20.30.0-0.5-0.5
Total sessions with >9 infusions0.70.82.9-0.81.30.11.4-0.31.7-0.4-0.5-0.7-0.7-1.0-0.7
Short access day 1 total inactive lever presses1.31.75.7-2.41.72.00.71.81.11.30.30.50.3-0.5-0.3
Short access day 10 total inactive lever presses0.51.23.3-1.61.81.61.21.10.40.7-0.8-0.3-0.5-0.9-0.9
Short access day 1 total infusions0.60.72.8-1.40.91.00.70.81.70.70.60.40.4-0.10.2
Short access day 10 total infusions0.40.62.5-0.61.00.11.1-0.11.6-0.3-0.3-0.6-0.4-0.6-0.6
Short access total infusions0.40.62.9-1.11.10.50.90.21.70.20.1-0.1-0.0-0.5-0.2
Short access day 1 locomotion0.20.31.2-0.70.70.81.10.50.4-0.20.10.10.0-0.10.0
Short access day 10 total locomotion0.40.71.5-0.91.20.30.70.01.20.0-0.8-0.7-0.8-1.1-0.8
Short access total locomotion0.81.02.8-1.11.50.41.70.11.6-0.3-0.6-0.7-0.8-0.9-0.8
One hour access (0.3 mA shock)0.40.51.9-1.21.40.40.60.31.00.3-0.3-0.3-0.2-0.6-0.5
Compulsive drug intake0.10.10.4-0.10.20.5-0.30.2-0.60.1-0.10.20.1-0.6-0.0
One hour access (shock baseline)0.20.21.7-0.70.4-0.10.10.01.30.40.30.00.20.40.2
Social response proportion0.91.01.9-0.3-0.80.5-0.50.70.91.31.21.21.01.41.3
Social responses0.60.83.1-0.80.21.10.71.11.81.20.50.60.50.80.5
Social time1.62.29.8-1.80.61.61.11.63.11.61.10.80.70.90.7
Soleus weight0.20.51.71.3-1.3-0.6-0.3-0.3-1.1-0.40.30.20.20.40.3
Bone: stiffness1.32.15.7-2.42.12.20.71.90.91.70.20.80.6-1.0-0.0
Tibialis anterior weight0.41.34.9-1.01.70.82.20.21.70.0-0.8-0.7-0.7-0.7-1.2
Time to tail flick, vehicle, before self-admin2.22.34.1-0.7-1.01.2-1.01.70.41.82.01.92.01.52.0
Time to tail flick, vehicle, after self-admin0.50.62.00.4-1.10.1-1.10.0-0.40.10.70.70.71.41.1
Time to tail flick, test, before self-admin2.82.97.22.4-2.7-1.9-1.4-1.3-2.6-0.80.80.40.82.11.4
Time to tail flick, test, after self-admin0.30.41.3-0.40.80.91.10.4-0.4-0.0-0.4-0.3-0.4-0.7-0.4
Delta time to tail flick, vehicle, before/after SA1.00.92.01.0-0.1-1.2-0.8-1.4-0.7-1.3-1.1-1.1-1.0-0.3-0.8
Delta time to tail flick, test, before/after SA2.22.36.6-2.42.02.61.02.11.41.50.30.60.1-1.0-0.3
Tibia length1.33.69.5-3.12.12.51.22.32.82.11.01.11.10.30.5
Ambulatory time before self-admin0.60.83.40.7-1.30.2-0.40.3-1.80.30.81.00.81.00.9
Ambulatory time after self-admin1.41.64.8-1.81.12.21.02.00.51.80.41.00.6-0.00.2
Bone: tissue strength0.00.00.30.2-0.3-0.10.0-0.00.10.10.20.00.20.60.2
Total heroin consumption0.10.10.30.40.1-0.00.2-0.2-0.4-0.5-0.5-0.4-0.5-0.2-0.3
Bone: trabecular number0.81.43.2-1.61.11.80.71.51.51.50.70.90.80.20.4
Bone: trabecular spacing1.01.33.11.00.0-1.20.5-1.3-0.8-1.8-1.4-1.5-1.3-0.6-1.1
Bone: trabecular thickness1.51.83.5-0.5-0.81.1-0.81.3-0.21.51.91.91.81.31.9
Bone: trabecular tissue density2.02.95.52.1-0.6-2.0-0.3-2.3-2.4-2.1-1.6-1.6-1.6-1.3-1.3
Water consumed over 24 hours0.20.20.6-0.3-0.00.80.10.6-0.30.20.60.60.6-0.00.6
Number of responses in last shaping day1.21.33.7-1.60.91.90.31.70.81.30.91.00.90.20.7