Cpxm1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Cpxm1	0.06	0.04	1.4e-04	0.04	0.02	0.05	0.03	3.7e-04	6.5e-03	7.3e-05	1.8e-03
2	Adipose	gene expression	Cpxm1	0.06	0.04	3.1e-08	0.05	0.05	0.06	0.06	1.1e-06	1.6e-06	5.5e-07	9.6e-07
3	PL	intron excision ratio	chr3_138054998_138070844	0.03	0.02	2.5e-04	0.02	0.03	0.01	0.02	1.4e-03	8.3e-04	3.8e-02	4.4e-03
4	PL	intron excision ratio	chr3_138070549_138070844	0.02	0.02	3.6e-03	0.02	0.02	0.03	0.01	5.1e-03	4.6e-03	2.3e-04	9.6e-03
5	IC	gene expression	Cpxm1	0.11	0.09	5.6e-03	-0	0.04	0.02	0.01	4.1e-01	1.1e-02	5.3e-02	1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.2	0.3	1.0	1.0	-0.6	0.4	0.0	-0.1
Area under the delay curve	0.2	0.2	0.7	-0.8	0.4	-0.4	0.3	-0.0
BMI with tail	0.2	0.6	1.0	0.7	-1.0	0.8	-0.7	0.8
BMI without tail	2.5	7.7	8.5	2.5	-2.7	2.9	-2.8	2.9
Body weight	3.4	14.8	16.0	4.0	-3.9	4.0	-3.6	3.7
Weight adjusted by age	2.0	3.1	5.5	2.3	-1.8	1.9	-1.1	1.5
Bone surface	0.4	0.6	1.6	1.3	-0.9	0.8	-0.4	0.3
Bone volume	0.4	0.7	1.6	1.3	-1.0	0.7	-0.4	0.3
Breakpoint value in progressive ratio session	2.2	2.7	3.1	1.7	-1.3	1.8	-1.7	1.7
Number of licking bursts	0.1	0.2	0.5	-0.7	0.5	-0.2	0.3	0.2
Context. condit. distance diff. score	0.2	0.2	0.4	0.6	-0.1	-0.2	0.5	-0.6
Locomotion velocity, session 1	0.3	0.4	0.8	0.6	-0.6	0.5	-0.9	0.2
Locomotion distance, session 1	0.3	0.3	0.8	0.9	-0.6	0.1	-0.3	-0.6
Locomotion velocity, session 2	0.1	0.2	0.3	-0.3	0.4	-0.4	0.3	-0.6
Locomotion distance, session 2	1.0	1.4	2.9	1.7	-1.3	0.9	-1.3	0.3
Locomotion velocity, session 3	1.1	1.3	1.5	1.2	-1.1	1.2	-0.9	1.1
Locomotion distance, session 3	6.0	6.5	7.4	2.7	-2.6	2.7	-2.3	2.4
Stereotopy head waving bouts, day 3	1.6	1.9	2.9	-0.8	1.4	-1.3	1.4	-1.7
Stereotopy head waving duration, day 3	1.0	1.2	1.7	-1.0	1.3	-1.1	0.8	-1.2
Locomotion velocity, session 7	0.6	0.7	1.1	1.1	-0.7	0.9	-0.8	0.6
Locomotion distance, session 7	0.4	0.6	1.3	1.1	-0.7	0.6	-0.7	0.2
Stereotopy head waving bouts, day 7	0.4	0.5	0.9	0.5	-0.4	0.8	-0.7	0.9
Stereotopy head waving duration, day 7	0.1	0.2	0.3	0.2	-0.1	0.4	-0.4	0.6
Locomotion velocity, session 8	0.3	0.4	1.1	1.0	-0.6	0.2	-0.3	-0.4
Locomotion distance, session 8	1.4	2.0	5.8	2.4	-1.6	1.0	-0.9	-0.1
Degree of sensitization distance	2.1	2.2	2.9	-1.3	1.6	-1.6	1.2	-1.7
Degree of sensitization stereotypy	2.7	2.9	4.0	1.4	-1.6	1.8	-1.7	2.0
Conditioned locomotion	3.5	4.0	5.7	2.3	-2.4	2.0	-1.7	1.5
Cocaine response after cond. corrected	0.1	0.2	0.4	-0.2	0.2	-0.5	0.3	-0.6
Cocaine response after cond. not corrected	0.2	0.2	0.3	-0.4	0.4	-0.5	0.1	-0.5
Cocaine response before conditioning	0.1	0.1	0.3	-0.5	0.5	-0.2	-0.2	-0.0
Saline control response	7.2	9.6	11.8	3.4	-3.2	3.2	-2.9	2.7
Bone: connectivity density	0.1	0.1	0.3	0.6	-0.4	0.0	0.2	-0.4
Bone: cortical apparent density	1.2	1.6	3.3	0.7	-0.7	1.4	-1.3	1.8
Bone: cortical area	3.4	5.3	6.5	2.4	-2.5	2.3	-2.2	2.0
Bone: cortical porosity	0.4	0.4	1.5	-0.2	-0.3	0.6	-0.5	1.2
Bone: cortical porosity	0.7	0.8	1.9	0.3	-0.8	0.9	-0.8	1.4
Bone: cortical thickness	1.7	2.9	3.3	1.5	-1.7	1.7	-1.8	1.7
Bone: cortical thickness	0.4	0.4	0.5	0.4	-0.7	0.6	-0.7	0.7
Bone: cortical tissue density	1.0	1.3	2.9	0.6	-0.5	1.3	-1.2	1.7
Condit. Reinf. active minus inactive responses	0.8	0.9	1.4	0.7	-0.7	1.0	-1.1	1.2
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.8	0.9	-0.7	0.9	-0.8	0.8
Condit. Reinf. active responses	0.6	0.7	1.2	0.6	-0.6	0.9	-1.0	1.1
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	-0.0	0.0	-0.3	0.0
Incentive salience index mean	0.4	0.5	0.7	0.5	-0.5	0.8	-0.8	0.9
Condit. Reinf. lever presses	0.1	0.1	0.1	0.1	-0.1	0.3	-0.4	0.4
Condit. Reinf. active minus inactive responses	2.1	2.7	3.6	1.9	-1.6	1.7	-1.7	1.3
Condit. Reinf. active-inactive response ratio	2.0	2.3	2.8	1.7	-1.5	1.6	-1.6	1.3
Condit. Reinf. active responses	3.4	4.8	6.0	2.4	-2.3	2.2	-2.2	1.7
Condit. Reinf. inactive responses	0.5	0.6	1.1	1.0	-1.0	0.7	-0.6	0.4
Condit. Reinf. lever presses	1.7	2.3	3.2	1.3	-1.6	1.5	-1.8	1.5
Condit. Reinf. lever reinforcers received	2.6	3.6	4.7	2.2	-2.0	1.9	-1.9	1.4
Conditioned reinforcement - actives	0.0	0.1	0.1	-0.2	-0.2	-0.0	-0.4	0.2
Conditioned reinforcement - inactives	0.1	0.2	0.4	0.6	-0.6	0.1	0.2	-0.3
Conditioned locomotion	0.0	0.0	0.2	-0.4	0.1	-0.1	-0.1	0.2
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.7	-0.2	0.0	0.5	-0.5
Patch foraging indifference point AUC	0.6	0.9	1.1	1.0	-0.9	1.1	-0.6	1.0
Delay disc. indifference point, 0s delay	1.7	1.9	3.2	-1.8	1.6	-1.5	0.6	-1.1
Delay disc. indifference point, 16s delay	0.5	0.5	1.3	-1.1	0.8	-0.7	0.3	-0.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	-0.3	-0.0	-0.2	0.7	-0.0
Delay disc. indifference point, 24s delay	2.0	2.3	3.6	-1.9	1.6	-1.5	1.4	-1.1
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.0	-0.4	0.4	-0.6	0.7
Delay disc. indifference point, 8s delay	0.3	0.3	0.9	-1.0	0.7	-0.4	0.4	0.1
Indifference point function ln k	0.0	0.0	0.2	0.4	-0.2	0.2	-0.1	-0.1
Indifference point function log k	0.0	0.0	0.2	0.4	-0.2	0.2	-0.1	-0.1
Patch foraging total patch changes 0 sec	0.1	0.3	0.7	0.9	-0.3	0.1	0.5	-0.5
Patch foraging total patch changes 12 sec	0.3	0.4	0.9	1.0	-0.6	0.7	-0.0	0.5
Patch foraging total patch changes 18 sec	0.4	0.7	1.1	-0.4	0.7	-0.9	0.9	-1.1
Patch foraging total patch changes 24 sec	1.0	1.7	2.7	-0.9	1.0	-1.4	1.3	-1.7
Patch foraging total patch changes 6 sec	0.4	0.6	1.6	1.3	-0.8	0.6	-0.3	-0.0
Patch foraging time to switch 0 sec	1.2	2.4	4.7	-2.2	1.9	-1.5	1.0	-0.8
Patch foraging water rate 0 sec	2.4	5.1	9.4	3.1	-2.6	2.3	-1.5	1.3
Patch foraging water rate 12 sec	0.1	0.2	0.4	0.6	-0.5	0.2	0.4	-0.3
Patch foraging water rate 18 sec	0.3	0.5	1.0	0.6	-1.0	0.6	-0.7	0.4
Patch foraging water rate 24 sec	0.7	0.9	1.1	0.7	-1.1	1.0	-1.0	1.0
Patch foraging water rate 6 sec	1.9	2.8	3.4	1.8	-1.8	1.8	-1.3	1.5
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.4	-0.6	0.7	-0.4	-0.0	-0.2
Distance traveled before self-admin	3.6	4.7	7.6	2.8	-2.4	2.1	-1.8	1.5
Distance traveled after self-admin	2.0	2.5	3.1	1.8	-1.6	1.5	-1.7	1.2
Extensor digitorum longus weight	0.1	0.4	1.4	0.3	-0.5	0.3	-1.2	0.2
Bone: elastic displacement	0.2	0.2	0.4	-0.4	-0.0	0.2	-0.6	0.6
Bone: elastic work	0.2	0.2	0.4	-0.2	-0.3	0.3	-0.7	0.6
Bone: endosteal estimation	0.6	1.2	1.9	1.4	-1.4	1.0	-0.9	0.6
Bone: endosteal perimeter	2.2	4.7	7.0	2.6	-2.6	2.1	-1.8	1.5
Epididymis fat weight	0.0	0.1	0.2	-0.3	0.4	-0.2	0.3	-0.2
Delta time in closed arm before/after self-admin	0.7	0.6	1.1	-0.9	0.7	-0.7	1.1	-0.5
Delta time in open arm before/after self-admin	0.7	0.7	1.7	1.3	-1.1	0.4	-0.4	-0.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	0.3	-0.2	0.3	-0.0	0.3
Delay discount exponential model param	0.2	0.2	0.6	0.8	-0.4	0.3	-0.4	0.0
Extinction: sum of active levers before priming	1.6	1.7	2.0	1.3	-1.4	1.3	-1.2	1.3
Active lever presses in extinction session 6	0.0	0.0	0.1	0.2	0.3	-0.0	0.1	-0.1
Bone: final force	3.4	5.4	6.1	2.3	-2.5	2.4	-2.2	2.2
Bone: final moment	2.6	4.2	5.1	2.0	-2.3	2.1	-2.0	1.9
Food consumed during 24 hour testing period	1.1	1.5	3.6	-0.7	0.9	-1.1	1.9	-1.1
Glucose	0.2	0.3	0.7	0.6	-0.9	0.3	-0.2	0.1
Heart weight	2.2	3.4	7.1	2.7	-2.2	1.9	-0.8	1.0
Delay discount hyperbolic model param	0.2	0.2	0.5	0.7	-0.4	0.3	-0.4	0.0
Intermittent access intake day 1-15 change	0.1	0.3	0.4	0.3	-0.4	0.5	-0.5	0.7
Intermittent access intake escalation	0.2	0.3	0.6	0.3	-0.5	0.6	-0.6	0.7
Intermittent access intake escalation 2	0.2	0.2	0.3	0.2	-0.5	0.4	-0.4	0.6
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.6	0.8	-0.7	0.4	0.0	0.0
Intermitt. access day 15 inactive lever presses	0.2	0.4	1.1	0.2	0.2	-0.6	0.6	-1.1
Intermitt. access escalation Index	0.1	0.1	0.4	0.4	-0.3	0.2	-0.6	0.1
Intermittent access day 1 total infusions	0.0	0.1	0.2	0.0	-0.1	0.1	-0.4	0.3
Intermittent access day 15 total infusions	0.1	0.1	0.4	0.2	-0.3	0.2	-0.6	0.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	0.2	-0.3	0.2	-0.7	0.1
Intermittent access total infusions	0.1	0.1	0.4	0.2	-0.2	0.2	-0.6	0.1
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.2	0.4	-0.3	0.4	-0.3
Intermittent access day 15 total locomotion	0.1	0.2	0.4	0.6	-0.6	0.1	-0.1	-0.3
Intermittent access total locomotion	0.3	0.3	0.6	0.6	-0.7	0.4	-0.8	0.3
Intermittent access standard deviation	0.2	0.5	0.7	0.5	-0.6	0.7	-0.8	0.8
Left kidney weight	0.1	0.3	0.7	0.8	-0.3	-0.1	0.1	-0.7
Right kidney weight	0.1	0.3	0.9	0.9	-0.5	-0.0	0.1	-0.7
Cocaine induced anxiety	4.3	6.1	6.7	-2.4	2.5	-2.5	2.6	-2.4
Post-drug Anxiety	3.5	3.8	4.6	-2.0	2.1	-2.0	1.7	-1.9
Baseline Anxiety	0.2	0.3	0.9	0.2	-0.2	0.4	-0.9	0.4
Tail length	4.0	15.7	17.4	4.2	-3.7	4.1	-4.1	3.7
Length with tail	5.5	24.1	28.4	5.3	-4.8	5.1	-4.7	4.5
Length without tail	2.0	6.5	10.1	3.2	-2.8	2.6	-2.0	2.0
Times rat made contact with spout	0.2	0.3	0.9	0.3	0.1	-0.3	1.0	-0.5
Lifetime Intake	0.3	0.4	1.0	0.5	-0.5	0.4	-1.0	0.3
Liver weight, left	0.7	1.2	2.1	1.4	-1.3	1.1	-0.8	0.8
Liver weight, right	0.2	0.4	0.7	0.6	-0.5	0.8	-0.6	0.8
Locomotor activity	0.1	0.2	0.4	0.1	-0.6	0.5	-0.2	0.6
Locomotor testing distance	0.1	0.2	0.3	-0.5	0.1	-0.4	0.4	-0.5
Locomotor testing rearing	0.1	0.3	0.5	0.6	-0.7	0.5	-0.5	0.1
Locomotion in novel chamber	0.1	0.2	0.7	-0.3	-0.1	0.1	-0.8	0.3
Locomotion in novel chamber post-restriction	0.4	0.7	0.9	0.8	-1.0	0.9	-0.2	0.8
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	0.0	-0.0	0.1	0.2	0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.3	0.2	-0.4	0.5	-0.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.0	-0.4	0.3	-0.1	0.4
Bouts of movement, locomotor time 1	1.4	1.6	2.8	-1.7	1.7	-1.3	0.5	-0.8
Total resting periods, locomotor time 1	1.1	1.3	2.4	-1.6	1.5	-1.1	0.3	-0.6
Rest time, locomotor task time 1	0.2	0.3	0.6	-0.7	0.8	-0.4	-0.1	-0.1
Distance moved, locomotor task time 1	0.0	0.1	0.1	0.3	-0.4	-0.1	0.2	-0.2
Vertical activity count, locomotor time 1	0.1	0.3	0.6	0.6	-0.6	0.1	0.7	-0.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.1	0.4	0.0	-0.5	0.1
Bouts of movement, locomotor time 2	0.3	0.4	0.9	-1.0	0.9	-0.5	-0.2	0.0
Total resting periods, locomotor time 2	0.2	0.4	1.0	-1.0	0.9	-0.4	-0.2	0.2
Rest time, locomotor task time 2	0.3	0.3	0.8	-0.9	0.5	-0.2	0.7	0.2
Distance moved, locomotor task time 2	0.2	0.2	0.6	0.4	-0.2	-0.3	-0.2	-0.8
Vertical activity count, locomotor time 2	0.3	0.4	0.9	0.9	-0.5	0.0	0.6	-0.6
Light reinforcement 1	0.5	1.2	2.1	1.1	-0.7	1.4	-0.7	1.5
Light reinforcement 2	0.5	0.8	1.1	1.0	-0.7	1.0	-0.6	1.0
Bone: marrow area	0.5	1.1	1.9	1.4	-1.3	1.0	-0.9	0.6
Bone: maximum diameter	4.1	7.6	10.2	3.2	-3.2	2.7	-2.5	2.1
Bone: maximum force	1.0	1.8	2.3	1.4	-1.5	1.3	-1.4	1.1
Bone: maximum moment	0.5	0.9	1.4	0.9	-1.2	0.9	-1.0	0.7
Mean time between licks in bursts	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.0	0.0
Mean num. licks in bursts	0.2	0.3	0.7	0.8	-0.4	-0.0	0.3	-0.6
Cd content in liver	2.0	2.3	2.5	1.6	-1.5	1.5	-1.5	1.5
Co content in liver	2.8	3.3	4.0	1.7	-1.7	1.8	-2.0	1.8
Cu content in liver	3.0	3.6	4.7	2.2	-2.1	1.9	-1.6	1.5
Fe content in liver	0.0	0.0	0.1	0.0	-0.3	0.2	-0.3	0.2
K content in liver	0.4	0.4	0.6	0.8	-0.7	0.6	-0.2	0.5
Mg content in liver	3.5	3.5	4.7	2.0	-2.2	1.9	-1.7	1.6
Mn content in liver	2.2	2.5	3.5	1.9	-1.5	1.7	-1.3	1.4
Na content in liver	0.3	0.3	0.6	-0.5	0.5	-0.7	0.1	-0.7
Rb content in liver	3.4	4.0	6.8	2.6	-2.6	1.8	-1.4	1.1
Se content in liver	1.1	1.3	1.6	1.2	-1.3	1.2	-0.8	1.1
Sr content in liver	0.5	0.5	0.5	0.6	-0.7	0.7	-0.7	0.7
Zn content in liver	1.8	2.0	2.3	1.4	-1.5	1.5	-1.1	1.5
Bone: minimum diameter	1.6	3.0	4.2	2.0	-2.1	1.7	-1.4	1.3
Time in familiar zone, hab. session 1	1.5	1.4	1.9	-1.1	1.4	-1.2	1.1	-1.2
Time in novel zone, hab. session 1	0.4	0.4	0.8	0.8	-0.9	0.6	-0.5	0.4
Total zone transitions, hab. session 1	0.1	0.2	0.5	0.7	-0.3	0.2	-0.4	-0.2
Total locomotion distance, hab. session 1	0.1	0.1	0.4	0.4	0.1	-0.2	-0.0	-0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.3	0.5	-0.1	-0.0	-0.2	-0.4
Time in familiar zone, hab. session 2	1.6	1.7	1.8	-1.2	1.3	-1.3	1.3	-1.3
Time in novel zone, hab. session 2	1.7	1.7	1.9	1.2	-1.4	1.3	-1.3	1.3
Total zone transitions, hab. session 2	2.2	2.8	3.4	1.9	-1.5	1.7	-1.8	1.5
Total locomotion distance, hab. session 2	0.4	0.5	1.4	1.2	-0.6	0.5	-0.6	-0.1
Locomotion velocity, hab. session 2	0.2	0.2	0.8	0.9	-0.3	0.1	-0.3	-0.4
Novel to familiar place preference ratio	0.2	0.2	0.5	-0.2	0.2	-0.5	0.2	-0.7
Novelty place preference	0.3	0.4	0.8	-0.4	0.4	-0.7	0.4	-0.9
Time in novel zone, NPP test	0.2	0.2	0.5	-0.3	0.2	-0.5	0.2	-0.7
Total zone transitions, NPP test	0.1	0.2	0.5	0.4	-0.2	0.4	-0.7	0.5
Total locomotion distance, NPP test	0.1	0.2	0.5	0.7	-0.3	0.1	-0.4	-0.4
Locomotion velocity, NPP test	0.1	0.1	0.5	0.3	0.0	-0.2	-0.1	-0.7
Intraocular pressure	0.1	0.2	0.6	0.0	0.1	0.2	-0.7	0.4
Delta distance traveled before/after self-admin	0.3	0.3	0.9	0.3	-0.3	0.5	-0.9	0.6
Delta ambulatory time before/after self-admin	0.3	0.4	0.8	-0.9	0.8	-0.6	0.1	-0.2
Parametrial fat weight	0.2	0.4	1.0	-0.7	0.5	-0.4	1.0	-0.0
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.3	-0.5	0.6	-0.4	0.7
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	0.4	-0.4	0.4	-0.5	0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.3	-0.2	0.2	-0.2	0.1
Pavlov. Cond. index score	0.0	0.0	0.0	0.0	0.2	-0.1	-0.0	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.2	0.4	-0.4	0.3	-0.5
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.1	0.1	-0.1	0.2	-0.3
Pavlov. Cond. magazine entry number	0.6	0.7	1.1	-0.6	0.6	-0.9	1.0	-1.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.4	-0.3	0.2	-0.3	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.0	0.2	-0.0	-0.2	-0.0
Pavlov. Cond. response bias	0.3	0.4	0.6	0.6	-0.5	0.7	-0.8	0.7
Pavlov. Cond. lever latency	4.8	6.5	8.3	-2.3	2.5	-2.6	2.9	-2.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.3	-0.2	-0.1	0.1	-0.3
Pavlov. Cond. change in total contacts	3.1	5.1	5.5	2.0	-2.3	2.4	-2.3	2.3
Pavlov. Cond. index score	3.0	4.1	4.7	1.9	-2.1	2.0	-2.2	1.8
Pavlov. Cond. latency score	2.4	3.2	3.8	1.7	-1.9	1.7	-2.0	1.6
Pavlov. Cond. lever contacts	4.1	5.6	6.8	2.2	-2.4	2.4	-2.6	2.2
Pavlov. Cond. magazine entry number	0.5	0.7	1.0	-0.8	1.0	-0.8	0.6	-0.8
Pavlov. Cond. intertrial magazine entries	0.8	1.3	2.2	-0.9	1.0	-1.1	1.5	-1.1
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.4	3.8	1.8	-2.0	1.8	-1.9	1.7
Pavlov. Cond. response bias	4.2	5.7	6.4	2.3	-2.5	2.4	-2.5	2.2
Time in closed arm before self-admin	0.2	0.2	0.7	-0.8	0.6	-0.4	0.1	-0.1
Time in closed arm after self-admin	1.0	1.0	1.8	-1.3	0.9	-0.9	1.3	-0.3
Time in open arm before self-admin	0.2	0.2	0.5	-0.5	0.7	-0.2	0.2	0.0
Time in open arm after self-admin	0.4	0.5	1.3	1.1	-0.6	0.5	-0.7	-0.0
Bone: periosteal estimation	2.1	4.5	6.0	2.3	-2.4	2.1	-2.0	1.7
Bone: periosteal perimeter	2.8	4.8	7.9	2.6	-2.8	2.0	-1.9	1.3
Bone: post-yield work	0.5	0.7	1.0	-0.8	0.8	-0.9	1.0	-0.8
Progressive ratio test 1 active lever presses	1.5	1.8	2.5	1.3	-1.4	1.3	-1.6	1.1
Progressive ratio test 1 breakpoint	1.5	1.8	2.4	1.3	-1.4	1.3	-1.6	1.1
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.4	-0.3	0.3	-0.4	0.1
Progressive ratio test 2 active lever presses	0.3	0.4	0.7	0.8	-0.8	0.4	-0.4	0.2
Progressive ratio test 2 breakpoint	0.4	0.4	0.8	0.9	-0.9	0.5	-0.5	0.3
Progressive ratio test 2 inactive lever presses	0.3	0.5	1.2	1.1	-1.0	0.5	-0.2	-0.0
Incentive Sensitization - Responses	0.2	0.3	0.7	0.7	-0.8	0.4	-0.4	0.2
Incentive Sensitization - Breakpoint	0.1	0.2	0.4	0.5	-0.7	0.2	-0.2	-0.0
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.1	1.1	-0.7	0.8	-0.4	0.4
Progressive ratio	2.9	4.6	7.7	-2.3	2.8	-2.0	2.0	-1.5
Food seeking constrained by brief footshock	0.1	0.2	0.5	0.6	-0.1	-0.1	-0.0	-0.7
Seeking ratio, punishment vs. effort	2.1	3.1	5.6	2.2	-2.4	1.6	-1.2	0.9
Retroperitoneal fat weight	0.7	2.8	3.8	-1.5	1.9	-1.6	1.9	-1.3
Reaction time number correct	0.1	0.2	0.4	0.6	-0.5	0.5	0.0	0.1
Reaction time mean minus median	0.3	0.7	0.9	-0.8	0.9	-0.9	0.8	-0.9
Reaction time mean minus median AUC	0.2	0.4	0.6	-0.5	0.7	-0.7	0.6	-0.8
Reaction time num false alarms	1.1	1.6	3.1	1.8	-1.1	1.3	-1.1	0.8
Reaction time num false alarms AUC	1.1	1.7	2.9	1.7	-1.1	1.4	-1.1	1.1
Reaction time trials correct on left	0.1	0.2	0.4	0.6	-0.5	0.5	0.0	0.1
Reaction time trials on left	0.1	0.2	0.5	0.7	-0.5	0.5	-0.0	0.1
Reaction time mean	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.3	0.3
Reaction time mean AUC	0.0	0.0	0.1	-0.1	0.0	-0.0	-0.2	0.1
Median of all reaction times	0.1	0.1	0.2	0.1	-0.3	0.3	-0.5	0.4
Reaction time omissions	0.4	0.6	1.1	1.1	-0.5	0.8	-0.7	0.5
Reaction time false alarm rate	0.7	1.0	1.5	1.2	-0.8	1.0	-1.0	0.8
Reaction time premature initiation rate	0.1	0.2	0.7	-0.8	0.4	-0.3	-0.2	-0.0
Reaction time premature initiations	0.1	0.1	0.4	-0.6	0.4	-0.2	-0.0	-0.2
Std. dev. reaction times	0.1	0.3	0.6	0.2	-0.3	0.6	-0.6	0.7
Reaction time trials completed	0.1	0.2	0.5	0.7	-0.5	0.5	-0.0	0.1
Reaction time trials AUC	0.1	0.2	0.6	0.8	-0.5	0.6	-0.1	0.2
Run reversals in cocaine runway, females	0.2	0.2	0.5	-0.1	0.4	-0.4	-0.0	-0.7
Run reversals in cocaine runway, males	0.8	0.8	1.2	1.0	-1.1	0.7	-1.0	0.4
Latency to leave start box in cocaine runway	0.5	0.6	1.2	-0.8	1.1	-0.7	0.9	-0.5
Latency to leave start box in cocaine runway, F	1.2	1.3	2.3	-1.3	1.5	-1.0	1.0	-0.7
Latency to leave start box in cocaine runway, M	0.3	0.3	0.4	0.6	-0.5	0.6	-0.3	0.6
Std. dev. time between licks in bursts	0.4	0.5	0.9	0.8	-1.0	0.6	-0.7	0.4
Total sessions with >9 infusions	0.6	0.8	1.8	0.5	-0.8	0.7	-1.4	0.7
Short access day 1 total inactive lever presses	2.0	2.7	3.7	-1.9	1.6	-1.7	1.5	-1.4
Short access day 10 total inactive lever presses	1.2	3.0	6.1	-1.4	1.4	-1.6	2.5	-1.6
Short access day 1 total infusions	0.1	0.1	0.2	-0.1	-0.0	-0.3	-0.2	-0.5
Short access day 10 total infusions	0.2	0.2	0.7	-0.4	0.3	-0.2	-0.8	0.1
Short access total infusions	0.2	0.3	1.2	0.3	-0.3	0.3	-1.1	0.3
Short access day 1 locomotion	0.6	0.7	1.7	-0.5	0.6	-1.0	0.6	-1.3
Short access day 10 total locomotion	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.0
Short access total locomotion	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.1	-0.3
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.1	-0.0	-0.1	-0.1	-0.2
Compulsive drug intake	1.7	2.0	2.4	-1.4	1.3	-1.4	1.6	-1.3
One hour access (shock baseline)	0.4	0.6	0.9	0.9	-0.7	0.8	-0.9	0.6
Social response proportion	0.9	1.0	2.8	1.7	-1.2	0.9	0.1	0.4
Social responses	3.8	4.9	6.8	2.6	-2.4	2.4	-1.6	2.0
Social time	0.3	0.4	0.6	0.8	-0.3	0.7	-0.8	0.5
Soleus weight	0.0	0.1	0.2	0.4	-0.3	-0.1	-0.3	-0.4
Bone: stiffness	2.2	3.6	4.1	2.0	-2.0	1.9	-1.9	1.6
Tibialis anterior weight	1.0	3.3	3.7	1.9	-1.8	1.9	-1.9	1.6
Time to tail flick, vehicle, before self-admin	1.7	1.7	2.9	-1.1	1.7	-1.3	1.0	-1.4
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.8	-0.9	0.9	-0.7	0.2	-0.4
Time to tail flick, test, before self-admin	1.2	1.3	2.1	1.0	-1.2	1.3	-0.5	1.4
Time to tail flick, test, after self-admin	0.8	0.8	2.2	-0.5	0.6	-0.8	1.5	-0.9
Delta time to tail flick, vehicle, before/after SA	2.9	2.8	3.2	1.6	-1.8	1.7	-1.6	1.6
Delta time to tail flick, test, before/after SA	1.5	1.5	2.5	-0.8	1.0	-1.3	1.3	-1.6
Tibia length	5.0	13.9	15.6	3.5	-3.8	3.8	-4.0	3.6
Ambulatory time before self-admin	2.6	3.9	5.3	2.3	-2.2	2.0	-1.6	1.7
Ambulatory time after self-admin	3.4	4.0	4.6	2.1	-2.1	1.9	-2.1	1.6
Bone: tissue strength	0.1	0.1	0.1	0.4	-0.3	0.3	-0.2	0.2
Total heroin consumption	2.5	2.9	4.2	2.1	-1.4	1.9	-1.5	1.5
Bone: trabecular number	0.5	0.8	1.6	1.3	-1.0	0.9	-0.7	0.5
Bone: trabecular spacing	0.1	0.1	0.3	-0.5	0.2	-0.1	0.0	0.2
Bone: trabecular thickness	0.3	0.4	1.0	1.0	-0.8	0.5	-0.3	0.2
Bone: trabecular tissue density	1.5	2.2	3.4	1.9	-1.6	1.6	-1.0	1.2
Water consumed over 24 hours	0.1	0.1	0.2	-0.2	0.4	-0.1	0.4	0.1
Number of responses in last shaping day	0.0	0.0	0.0	0.0	0.0	0.1	-0.0	-0.0