Hub : Genes

Cpxm1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Cpxm1	0.02	0.02	6.4e-03	0.03	0.01	0.01	0.02	6.8e-04	8.7e-03	7.8e-03	4.9e-03
2	Adipose	gene expression	Cpxm1	0.05	0.04	3.1e-07	0.05	0.05	0.05	0.05	2.5e-06	7.0e-06	6.9e-06	4.5e-06
3	PL	intron excision ratio	chr3_117601886_117617729	0.03	0.02	1.7e-04	0.03	0.03	0.03	0.01	1.2e-04	2.1e-04	7.8e-04	3.0e-02
4	PL	intron excision ratio	chr3_117617434_117617729	0.02	0.02	4.1e-03	0	0.01	0.03	0	8.2e-02	4.4e-02	8.7e-04	7.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.3	0.5	0.7	-0.8	0.7	-0.7	-0.3
Area under the delay curve	0.4	0.4	0.7	0.4	-0.8	0.8	-0.1
BMI with tail	1.4	4.6	5.1	-2.3	2.2	-2.2	1.8
BMI without tail	3.9	8.0	9.7	-3.1	2.6	-2.6	2.9
Body weight	6.3	26.6	29.0	-5.2	5.4	-5.4	4.6
Weight adjusted by age	2.7	3.0	3.9	-2.0	1.7	-1.7	1.5
Bone surface	0.4	0.7	1.3	-1.2	0.9	-0.9	0.2
Bone volume	0.4	0.8	1.2	-1.1	1.0	-1.0	0.1
Breakpoint value in progressive ratio session	4.0	4.4	5.7	-1.9	2.0	-2.0	2.4
Number of licking bursts	0.2	0.2	0.5	0.7	-0.3	0.3	0.2
Context. condit. distance diff. score	0.1	0.1	0.1	-0.3	0.4	-0.4	-0.2
Locomotion velocity, session 1	0.3	0.4	1.1	-0.6	0.0	-0.0	1.1
Locomotion distance, session 1	0.1	0.1	0.4	-0.6	0.1	-0.1	0.2
Locomotion velocity, session 2	0.2	0.3	0.5	0.1	-0.7	0.7	-0.3
Locomotion distance, session 2	0.8	1.1	1.9	-1.4	1.0	-1.0	0.8
Locomotion velocity, session 3	1.2	1.4	2.2	-1.5	1.1	-1.1	0.9
Locomotion distance, session 3	7.0	7.7	9.4	-3.1	2.9	-2.9	2.0
Stereotopy head waving bouts, day 3	1.9	2.2	2.8	1.5	-1.4	1.4	-1.7
Stereotopy head waving duration, day 3	1.0	1.2	1.6	1.3	-1.1	1.1	-0.8
Locomotion velocity, session 7	1.1	1.2	1.6	-1.0	1.3	-1.3	0.6
Locomotion distance, session 7	0.5	0.7	1.3	-1.2	0.7	-0.7	0.6
Stereotopy head waving bouts, day 7	0.5	0.5	0.7	-0.5	0.8	-0.8	0.8
Stereotopy head waving duration, day 7	0.2	0.3	0.4	-0.1	0.6	-0.6	0.6
Locomotion velocity, session 8	0.7	0.8	1.3	-0.8	1.1	-1.1	0.1
Locomotion distance, session 8	1.8	2.6	3.8	-2.0	1.8	-1.8	0.7
Degree of sensitization distance	2.2	2.2	2.7	1.5	-1.6	1.6	-1.0
Degree of sensitization stereotypy	2.6	2.9	3.3	-1.5	1.7	-1.7	1.8
Conditioned locomotion	2.4	2.8	4.8	-2.2	1.6	-1.6	1.2
Cocaine response after cond. corrected	0.0	0.1	0.1	0.2	-0.3	0.3	-0.1
Cocaine response after cond. not corrected	0.1	0.2	0.2	0.4	-0.5	0.5	-0.0
Cocaine response before conditioning	0.2	0.2	0.5	0.7	-0.4	0.4	0.1
Saline control response	6.2	8.1	10.0	-3.2	2.9	-2.9	2.2
Bone: connectivity density	0.1	0.1	0.3	-0.4	0.3	-0.3	-0.5
Bone: cortical apparent density	0.7	0.9	2.1	-0.9	0.6	-0.6	1.4
Bone: cortical area	3.7	5.6	6.9	-2.6	2.3	-2.3	2.1
Bone: cortical porosity	0.4	0.4	0.6	-0.7	0.5	-0.5	0.8
Bone: cortical porosity	0.9	0.9	1.1	-1.1	0.9	-0.9	1.0
Bone: cortical thickness	1.7	2.8	3.8	-2.0	1.5	-1.5	1.7
Bone: cortical thickness	0.4	0.4	0.6	-0.6	0.6	-0.6	0.8
Bone: cortical tissue density	0.6	0.7	1.8	-0.8	0.5	-0.5	1.3
Condit. Reinf. active minus inactive responses	1.1	1.2	1.6	-1.1	1.2	-1.2	0.8
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.7	-0.9	1.3	-1.3	0.3
Condit. Reinf. active responses	0.7	0.9	1.1	-1.0	0.9	-0.9	1.0
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.0	-0.3	0.3	0.4
Incentive salience index mean	0.6	0.7	1.1	-1.1	0.8	-0.8	0.7
Condit. Reinf. lever presses	0.1	0.2	0.5	-0.7	0.2	-0.2	0.4
Condit. Reinf. active minus inactive responses	1.4	1.8	2.1	-1.3	1.4	-1.4	1.1
Condit. Reinf. active-inactive response ratio	1.7	1.8	2.2	-1.2	1.5	-1.5	1.1
Condit. Reinf. active responses	2.2	3.0	3.6	-1.8	1.9	-1.9	1.3
Condit. Reinf. inactive responses	0.3	0.4	0.6	-0.7	0.7	-0.7	0.1
Condit. Reinf. lever presses	1.1	1.5	1.6	-1.2	1.2	-1.2	1.2
Condit. Reinf. lever reinforcers received	1.6	2.2	2.7	-1.6	1.6	-1.6	1.0
Conditioned reinforcement - actives	0.0	0.0	0.0	0.0	-0.1	0.1	0.1
Conditioned reinforcement - inactives	0.3	0.3	1.0	-0.3	0.3	-0.3	-1.0
Conditioned locomotion	0.1	0.2	0.5	0.3	0.0	-0.0	-0.7
Patch foraging indifference point 0 sec	0.3	0.5	2.1	0.0	0.1	-0.1	-1.4
Patch foraging indifference point AUC	0.5	0.5	0.8	-0.9	0.8	-0.8	0.3
Delay disc. indifference point, 0s delay	1.4	1.5	2.7	1.7	-1.3	1.3	0.5
Delay disc. indifference point, 16s delay	1.0	1.0	1.7	0.7	-1.3	1.3	-0.2
Delay disc. indifference point, 2s delay	0.2	0.2	0.8	0.1	-0.1	0.1	-0.9
Delay disc. indifference point, 24s delay	2.8	2.7	4.2	1.4	-2.0	2.0	-0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	-0.2	0.2	-0.2	0.6
Delay disc. indifference point, 8s delay	0.5	0.5	0.8	0.5	-0.9	0.9	-0.2
Indifference point function ln k	0.0	0.1	0.1	-0.4	0.1	-0.1	0.3
Indifference point function log k	0.0	0.1	0.1	-0.4	0.1	-0.1	0.3
Patch foraging total patch changes 0 sec	0.3	0.5	1.8	-0.1	0.2	-0.2	-1.3
Patch foraging total patch changes 12 sec	0.3	0.4	0.6	-0.8	0.6	-0.6	-0.4
Patch foraging total patch changes 18 sec	1.0	1.3	2.7	1.0	-0.8	0.8	-1.6
Patch foraging total patch changes 24 sec	1.8	2.2	3.6	1.5	-1.2	1.2	-1.9
Patch foraging total patch changes 6 sec	0.6	0.9	1.3	-0.6	1.0	-1.0	-1.1
Patch foraging time to switch 0 sec	1.5	2.3	2.7	1.6	-1.6	1.6	-1.1
Patch foraging water rate 0 sec	3.1	4.9	6.1	-2.3	2.5	-2.5	1.5
Patch foraging water rate 12 sec	0.1	0.1	0.3	0.0	0.4	-0.4	-0.5
Patch foraging water rate 18 sec	0.5	0.7	1.1	-0.6	1.0	-1.0	0.4
Patch foraging water rate 24 sec	0.7	0.9	2.0	-0.7	0.8	-0.8	1.4
Patch foraging water rate 6 sec	2.4	3.5	4.6	-1.5	1.9	-1.9	2.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.3	0.5	-0.5	0.5	-0.1
Distance traveled before self-admin	5.3	5.6	7.4	-2.4	2.7	-2.7	1.5
Distance traveled after self-admin	3.8	4.2	5.7	-1.8	2.4	-2.4	1.5
Extensor digitorum longus weight	0.3	1.0	1.7	-0.4	1.0	-1.0	1.3
Bone: elastic displacement	0.1	0.2	0.6	0.1	-0.0	0.0	0.8
Bone: elastic work	0.2	0.2	0.3	-0.2	0.5	-0.5	0.6
Bone: endosteal estimation	0.6	1.4	1.8	-1.2	1.3	-1.3	0.7
Bone: endosteal perimeter	2.3	4.7	5.5	-2.2	2.3	-2.3	1.7
Epididymis fat weight	1.3	3.1	3.8	-2.0	1.9	-1.9	1.3
Delta time in closed arm before/after self-admin	0.3	0.3	0.4	0.5	-0.5	0.5	-0.7
Delta time in open arm before/after self-admin	1.5	1.5	2.7	-0.7	1.6	-1.6	0.1
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.0	-0.1	0.1	-0.0
Delay discount exponential model param	0.4	0.4	0.7	-0.4	0.8	-0.8	0.3
Extinction: sum of active levers before priming	0.9	0.9	1.2	-0.7	1.1	-1.1	0.9
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	-0.3	0.3	0.1
Bone: final force	3.1	5.1	7.4	-2.7	2.1	-2.1	1.9
Bone: final moment	2.6	4.2	6.1	-2.5	2.0	-2.0	1.7
Food consumed during 24 hour testing period	1.2	1.5	2.7	1.2	-1.0	1.0	-1.6
Glucose	0.6	0.8	1.4	-0.7	1.2	-1.2	0.1
Heart weight	2.4	3.4	5.1	-2.3	1.9	-1.9	1.2
Delay discount hyperbolic model param	0.3	0.3	0.5	-0.3	0.7	-0.7	0.4
Intermittent access intake day 1-15 change	0.9	0.9	1.2	-0.7	1.1	-1.1	1.0
Intermittent access intake escalation	0.2	0.2	0.3	-0.2	0.5	-0.5	0.5
Intermittent access intake escalation 2	0.1	0.1	0.2	0.4	-0.0	0.0	-0.3
Intermitt. access day 1 inactive lever presses	0.9	0.9	2.8	0.8	-0.4	0.4	-1.7
Intermitt. access day 15 inactive lever presses	0.5	0.6	2.2	0.2	-0.0	0.0	-1.5
Intermitt. access escalation Index	0.2	0.1	0.5	-0.1	0.1	-0.1	0.7
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.0	-0.2	0.2	0.1
Intermittent access day 15 total infusions	0.1	0.1	0.1	-0.1	0.3	-0.3	0.3
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.1	0.2	-0.2	0.3
Intermittent access total infusions	0.0	0.0	0.1	-0.0	-0.0	0.0	0.3
Intermittent access day 1 locomotion	0.5	0.5	1.1	0.5	-0.6	0.6	-1.1
Intermittent access day 15 total locomotion	0.6	0.6	2.4	0.3	-0.2	0.2	-1.5
Intermittent access total locomotion	0.2	0.2	0.8	0.3	-0.2	0.2	-0.9
Intermittent access standard deviation	0.2	0.2	0.6	-0.2	0.3	-0.3	0.8
Left kidney weight	1.1	3.0	3.4	-1.8	1.8	-1.8	1.5
Right kidney weight	0.8	2.2	2.5	-1.6	1.5	-1.5	1.2
Cocaine induced anxiety	7.6	8.7	14.1	2.7	-2.6	2.6	-3.8
Post-drug Anxiety	2.3	2.6	2.8	1.6	-1.6	1.6	-1.7
Baseline Anxiety	1.5	1.6	4.1	-0.8	0.9	-0.9	2.0
Tail length	5.2	15.7	17.9	-4.0	3.8	-3.8	4.2
Length with tail	4.7	17.1	18.5	-4.2	4.3	-4.3	3.8
Length without tail	1.6	3.4	4.6	-1.6	2.1	-2.1	1.3
Times rat made contact with spout	0.2	0.3	1.0	0.4	-0.1	0.1	-1.0
Lifetime Intake	0.5	0.6	1.3	-0.5	0.6	-0.6	1.1
Liver weight, left	0.0	0.0	0.1	0.3	0.1	-0.1	0.0
Liver weight, right	0.3	0.4	1.3	-0.4	0.3	-0.3	1.1
Locomotor activity	0.0	0.0	0.2	-0.4	0.0	-0.0	0.0
Locomotor testing distance	0.3	0.4	0.6	0.6	-0.6	0.6	-0.8
Locomotor testing rearing	0.1	0.1	0.4	-0.2	-0.0	0.0	-0.6
Locomotion in novel chamber	0.2	0.3	0.4	0.4	-0.5	0.5	0.7
Locomotion in novel chamber post-restriction	0.7	0.8	1.0	-0.9	1.0	-1.0	0.6
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.3	0.4	-0.4	0.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.3	-0.4	0.4	-0.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.3	0.3	-0.3	0.2
Bouts of movement, locomotor time 1	1.4	1.6	2.2	1.4	-1.5	1.5	0.0
Total resting periods, locomotor time 1	1.3	1.4	1.9	1.3	-1.4	1.4	0.3
Rest time, locomotor task time 1	0.3	0.3	0.4	0.5	-0.6	0.6	0.1
Distance moved, locomotor task time 1	0.1	0.2	0.3	-0.2	0.4	-0.4	-0.6
Vertical activity count, locomotor time 1	0.5	0.5	1.3	-0.6	0.5	-0.5	-1.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.1	0.2	-0.2	0.5
Bouts of movement, locomotor time 2	0.1	0.2	0.4	0.7	-0.3	0.3	0.0
Total resting periods, locomotor time 2	0.2	0.2	0.5	0.7	-0.3	0.3	0.0
Rest time, locomotor task time 2	0.6	0.7	1.3	1.1	-0.8	0.8	-0.7
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.3	-0.0	0.0	-0.1
Vertical activity count, locomotor time 2	0.5	0.5	1.6	-0.6	0.3	-0.3	-1.3
Light reinforcement 1	0.5	0.9	1.2	-1.1	0.8	-0.8	1.1
Light reinforcement 2	0.4	0.6	0.8	-0.8	0.7	-0.7	0.9
Bone: marrow area	0.6	1.3	1.7	-1.1	1.3	-1.3	0.7
Bone: maximum diameter	4.2	7.7	9.0	-3.0	2.9	-2.9	2.2
Bone: maximum force	0.5	0.9	1.7	-1.3	0.8	-0.8	0.8
Bone: maximum moment	0.3	0.5	0.9	-0.9	0.6	-0.6	0.6
Mean time between licks in bursts	0.3	0.5	0.8	-0.3	0.9	-0.9	0.3
Mean num. licks in bursts	0.1	0.2	0.4	-0.4	0.1	-0.1	-0.7
Cd content in liver	0.3	0.3	0.8	0.1	-0.4	0.4	-0.9
Co content in liver	0.6	0.7	0.8	-0.9	0.9	-0.9	0.7
Cu content in liver	1.5	1.8	2.0	-1.4	1.4	-1.4	1.1
Fe content in liver	0.1	0.1	0.3	-0.1	0.2	-0.2	-0.6
K content in liver	0.3	0.3	0.6	-0.8	0.3	-0.3	0.7
Mg content in liver	1.5	1.5	2.2	-1.5	1.2	-1.2	0.9
Mn content in liver	1.2	1.4	2.5	-1.6	0.9	-0.9	1.1
Na content in liver	0.2	0.2	0.3	-0.1	-0.4	0.4	0.5
Rb content in liver	3.8	4.7	7.6	-2.0	2.7	-2.7	0.2
Se content in liver	0.4	0.4	0.9	-0.9	0.6	-0.6	0.4
Sr content in liver	0.8	0.7	1.1	-0.7	0.8	-0.8	1.0
Zn content in liver	0.1	0.1	0.4	-0.6	0.2	-0.2	0.3
Bone: minimum diameter	2.0	3.7	4.5	-2.1	2.1	-2.1	1.3
Time in familiar zone, hab. session 1	0.8	0.8	1.1	1.0	-0.8	0.8	-0.9
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.7	0.3	-0.3	0.3
Total zone transitions, hab. session 1	0.1	0.1	0.5	-0.7	-0.1	0.1	0.2
Total locomotion distance, hab. session 1	0.1	0.1	0.2	-0.2	-0.4	0.4	-0.0
Locomotion velocity, hab. session 1	0.1	0.1	0.1	-0.4	-0.4	0.4	0.2
Time in familiar zone, hab. session 2	1.5	1.6	1.7	1.3	-1.2	1.2	-1.3
Time in novel zone, hab. session 2	1.6	1.6	2.0	-1.2	1.2	-1.2	1.4
Total zone transitions, hab. session 2	2.5	3.3	5.2	-2.1	1.3	-1.3	2.3
Total locomotion distance, hab. session 2	0.4	0.5	1.0	-1.0	0.2	-0.2	1.0
Locomotion velocity, hab. session 2	0.2	0.2	0.4	-0.7	-0.2	0.2	0.6
Novel to familiar place preference ratio	0.1	0.1	0.2	0.4	-0.1	0.1	-0.3
Novelty place preference	0.2	0.2	0.4	0.6	-0.3	0.3	-0.4
Time in novel zone, NPP test	0.1	0.1	0.2	0.4	-0.1	0.1	-0.2
Total zone transitions, NPP test	0.3	0.5	1.2	-0.7	-0.3	0.3	1.1
Total locomotion distance, NPP test	0.2	0.2	0.4	-0.5	-0.3	0.3	0.6
Locomotion velocity, NPP test	0.2	0.3	0.5	-0.1	-0.7	0.7	0.4
Intraocular pressure	0.1	0.1	0.3	0.1	0.1	-0.1	0.6
Delta distance traveled before/after self-admin	0.2	0.2	0.3	-0.4	0.5	-0.5	0.6
Delta ambulatory time before/after self-admin	0.3	0.3	0.5	0.6	-0.7	0.7	-0.2
Parametrial fat weight	0.1	0.1	0.2	-0.1	-0.5	0.5	-0.1
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.0	0.3	-0.3	0.4
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.3	0.2	-0.2	0.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.4	0.2	-0.2	-0.0
Pavlov. Cond. index score	0.0	0.0	0.1	-0.3	0.1	-0.1	0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.1	-0.2	0.2	-0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.6	0.2	-0.2	0.1
Pavlov. Cond. magazine entry number	0.7	0.9	1.1	0.9	-0.9	0.9	-1.0
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	-0.1	0.6	-0.6	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.2	0.1	-0.1	0.2
Pavlov. Cond. response bias	0.5	0.7	0.8	-0.9	0.8	-0.8	0.7
Pavlov. Cond. lever latency	3.7	4.9	5.6	2.4	-2.1	2.1	-2.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	-0.3	0.4	-0.4	-0.6
Pavlov. Cond. change in total contacts	3.5	4.8	5.5	-2.3	2.2	-2.2	2.0
Pavlov. Cond. index score	3.2	4.1	4.9	-2.2	2.1	-2.1	1.6
Pavlov. Cond. latency score	2.3	2.9	3.6	-1.9	1.8	-1.8	1.3
Pavlov. Cond. lever contacts	3.7	5.1	5.4	-2.3	2.3	-2.3	2.1
Pavlov. Cond. magazine entry number	0.6	0.7	1.0	0.8	-1.0	1.0	-0.3
Pavlov. Cond. intertrial magazine entries	1.1	1.4	2.1	0.9	-1.5	1.5	-0.9
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.7	4.4	-2.1	2.0	-2.0	1.5
Pavlov. Cond. response bias	3.9	5.3	6.3	-2.3	2.5	-2.5	1.9
Time in closed arm before self-admin	0.0	0.0	0.1	0.3	-0.2	0.2	0.2
Time in closed arm after self-admin	0.3	0.3	0.6	0.5	-0.5	0.5	-0.8
Time in open arm before self-admin	0.9	0.9	1.7	0.4	-1.3	1.3	-0.5
Time in open arm after self-admin	0.0	0.0	0.1	-0.1	0.3	-0.3	0.1
Bone: periosteal estimation	2.6	5.4	6.2	-2.5	2.4	-2.4	1.9
Bone: periosteal perimeter	4.0	6.6	8.2	-2.6	2.9	-2.9	1.8
Bone: post-yield work	0.7	0.9	1.0	1.0	-0.9	0.9	-1.0
Progressive ratio test 1 active lever presses	3.1	3.2	3.6	-1.9	1.7	-1.7	1.9
Progressive ratio test 1 breakpoint	3.9	4.1	4.6	-2.1	2.0	-2.0	2.0
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.3	-0.3	0.5	-0.5	0.2
Progressive ratio test 2 active lever presses	0.4	0.4	0.4	-0.7	0.6	-0.6	0.7
Progressive ratio test 2 breakpoint	0.4	0.5	0.8	-0.7	0.5	-0.5	0.9
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.4	-0.2	0.2	-0.2	-0.7
Incentive Sensitization - Responses	0.6	0.6	0.7	-0.7	0.8	-0.8	0.8
Incentive Sensitization - Breakpoint	0.4	0.4	0.4	-0.5	0.7	-0.7	0.6
Sum of active levers in priming session hrs 5-6	0.6	0.5	0.8	-0.9	0.8	-0.8	0.4
Progressive ratio	2.9	3.4	4.3	1.9	-2.1	2.1	-1.1
Food seeking constrained by brief footshock	0.2	0.2	0.4	-0.6	0.4	-0.4	-0.4
Seeking ratio, punishment vs. effort	2.6	3.2	4.2	-2.0	2.1	-2.1	0.4
Retroperitoneal fat weight	0.1	0.3	1.0	-0.4	-0.1	0.1	1.0
Reaction time number correct	0.1	0.1	0.2	-0.3	0.4	-0.4	-0.1
Reaction time mean minus median	1.0	1.3	1.4	1.2	-1.2	1.2	-1.1
Reaction time mean minus median AUC	0.8	1.0	1.1	1.0	-1.0	1.0	-1.0
Reaction time num false alarms	1.6	2.2	3.3	-1.8	1.4	-1.4	1.3
Reaction time num false alarms AUC	1.8	2.4	3.6	-1.9	1.5	-1.5	1.4
Reaction time trials correct on left	0.1	0.1	0.2	-0.3	0.4	-0.4	-0.1
Reaction time trials on left	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.1
Reaction time mean	0.0	0.0	0.0	0.2	0.0	-0.0	-0.2
Reaction time mean AUC	0.0	0.0	0.1	0.3	-0.0	0.0	-0.3
Median of all reaction times	0.1	0.1	0.1	-0.1	0.4	-0.4	-0.0
Reaction time omissions	0.1	0.1	0.2	-0.5	0.4	-0.4	0.1
Reaction time false alarm rate	1.1	1.6	2.2	-1.5	1.1	-1.1	1.3
Reaction time premature initiation rate	0.2	0.3	0.4	0.6	-0.6	0.6	-0.4
Reaction time premature initiations	0.2	0.3	0.3	0.5	-0.6	0.6	-0.6
Std. dev. reaction times	0.0	0.1	0.1	-0.2	0.1	-0.1	0.4
Reaction time trials completed	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.1
Reaction time trials AUC	0.1	0.2	0.3	-0.4	0.5	-0.5	-0.1
Run reversals in cocaine runway, females	0.2	0.1	0.5	0.2	-0.1	0.1	-0.7
Run reversals in cocaine runway, males	1.0	1.0	1.2	-0.9	1.1	-1.1	0.9
Latency to leave start box in cocaine runway	0.6	0.7	0.9	0.5	-0.9	0.9	-0.9
Latency to leave start box in cocaine runway, F	1.1	1.2	1.4	1.0	-1.2	1.2	-1.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.3	0.1	-0.1	0.0
Std. dev. time between licks in bursts	0.9	1.0	1.3	-1.1	1.1	-1.1	0.6
Total sessions with >9 infusions	1.1	1.2	1.8	-0.9	1.1	-1.1	1.3
Short access day 1 total inactive lever presses	0.8	0.8	1.1	0.9	-1.1	1.1	-0.6
Short access day 10 total inactive lever presses	5.3	5.9	12.6	2.2	-1.8	1.8	-3.6
Short access day 1 total infusions	0.2	0.3	0.4	-0.3	0.5	-0.5	0.6
Short access day 10 total infusions	0.5	0.6	2.1	-0.3	0.2	-0.2	1.4
Short access total infusions	1.3	1.4	2.9	-0.8	1.0	-1.0	1.7
Short access day 1 locomotion	0.7	0.7	1.9	0.9	-0.3	0.3	-1.4
Short access day 10 total locomotion	0.1	0.1	0.4	0.1	0.3	-0.3	-0.7
Short access total locomotion	0.1	0.1	0.4	0.1	0.3	-0.3	-0.6
One hour access (0.3 mA shock)	0.0	0.0	0.0	0.2	-0.1	0.1	0.2
Compulsive drug intake	5.1	5.1	5.7	2.2	-2.4	2.4	-2.1
One hour access (shock baseline)	0.8	0.9	1.2	-0.7	1.0	-1.0	1.1
Social response proportion	0.8	0.8	1.1	-1.0	1.0	-1.0	-0.2
Social responses	3.3	4.3	5.8	-2.4	2.0	-2.0	1.7
Social time	0.3	0.5	0.8	-0.7	0.5	-0.5	0.9
Soleus weight	0.1	0.2	0.4	0.0	0.4	-0.4	0.6
Bone: stiffness	1.6	2.5	4.1	-2.0	1.4	-1.4	1.4
Tibialis anterior weight	0.9	3.2	3.4	-1.6	1.9	-1.9	1.8
Time to tail flick, vehicle, before self-admin	1.3	1.3	2.3	1.5	-1.2	1.2	-0.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.5	-0.0	0.1	-0.1	0.7
Time to tail flick, test, before self-admin	0.5	0.5	1.0	-1.0	0.6	-0.6	0.4
Time to tail flick, test, after self-admin	2.8	2.9	5.4	1.6	-1.4	1.4	-2.3
Delta time to tail flick, vehicle, before/after SA	2.7	2.7	3.9	-2.0	1.5	-1.5	1.5
Delta time to tail flick, test, before/after SA	3.0	2.7	3.8	1.9	-1.3	1.3	-2.0
Tibia length	5.3	14.8	18.1	-3.5	4.3	-4.3	3.3
Ambulatory time before self-admin	4.4	4.5	5.5	-2.2	2.4	-2.4	1.5
Ambulatory time after self-admin	4.8	5.3	7.0	-2.1	2.6	-2.6	1.7
Bone: tissue strength	0.1	0.1	0.3	-0.5	0.0	-0.0	0.5
Total heroin consumption	2.4	2.8	3.9	-2.0	1.8	-1.8	1.1
Bone: trabecular number	0.4	0.6	0.8	-0.9	0.8	-0.8	0.5
Bone: trabecular spacing	0.2	0.2	0.4	0.3	-0.6	0.6	-0.0
Bone: trabecular thickness	0.6	0.7	1.0	-0.8	1.0	-1.0	-0.3
Bone: trabecular tissue density	0.9	1.3	2.7	-1.6	1.0	-1.0	0.7
Water consumed over 24 hours	0.2	0.2	0.5	0.7	-0.4	0.4	-0.4
Number of responses in last shaping day	0.2	0.2	0.4	0.6	-0.2	0.2	-0.6