Hub : Genes

Cps1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Cps1 0.27 0.1 4.4e-08 0.17 0.17 0.14 0.21 1.4e-07 1.1e-07 2.4e-06 3.5e-09
2 pVTA mRNA stability Cps1 0.03 0.02 5.5e-03 0.01 0.03 0.01 0.01 9.8e-02 3.5e-03 2.9e-02 2.1e-02
3 PL gene expression Cps1 0.48 0.11 0.0e+00 0.23 0.33 0.33 0.33 5.4e-25 5.3e-37 6.8e-37 4.6e-37
4 Brain gene expression Cps1 0.29 0.06 0.0e+00 0.12 0.28 0.28 0.28 1.0e-11 7.8e-26 5.6e-26 4.6e-26
5 NAcc gene expression Cps1 0.18 0.07 1.8e-14 0.07 0.09 0.09 0.08 2.2e-11 8.2e-14 4.0e-13 2.5e-12
6 BLA gene expression Cps1 0.42 0.16 6.6e-09 0.16 0.18 0.14 0.17 6.3e-09 6.4e-10 8.3e-08 1.6e-09
7 pVTA gene expression Cps1 0.15 0.08 5.6e-05 0.05 0.07 0.03 0.06 1.1e-04 5.5e-06 1.1e-03 1.9e-05
8 IL gene expression Cps1 0.66 0.14 1.7e-07 0 0.14 0.1 0.12 3.1e-01 3.0e-04 2.3e-03 7.9e-04
9 Brain mRNA stability Cps1 0.06 0.04 1.6e-03 0.02 0.03 0.02 0.03 5.6e-03 1.6e-03 4.6e-03 1.1e-03
10 Liver gene expression Cps1 0.03 0.02 4.3e-03 0 0 -0 -0 9.7e-02 2.1e-01 9.2e-01 4.2e-01
11 OFC gene expression Cps1 0.93 0.06 1.8e-05 0.02 0.14 0.14 0.16 1.2e-01 4.3e-04 4.4e-04 1.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.20.41.1-0.4-0.90.70.50.50.40.50.60.30.21.0
Area under the delay curve0.91.11.81.00.11.31.01.31.21.31.40.9-0.30.7
BMI with tail2.06.919.44.43.22.82.62.52.92.62.22.0-0.2-1.2
BMI without tail0.72.04.92.21.21.71.51.51.51.41.21.4-0.6-0.4
Body weight0.31.34.60.1-1.70.50.71.31.21.00.41.4-2.1-0.0
Weight adjusted by age0.10.20.40.60.20.50.20.40.40.40.40.6-0.4-0.2
Bone surface0.20.31.5-0.4-0.9-0.2-0.30.2-0.1-0.1-0.10.4-1.2-0.6
Bone volume0.20.42.4-1.2-1.6-0.1-0.20.0-0.2-0.1-0.00.1-0.30.5
Breakpoint value in progressive ratio session0.81.02.0-0.90.2-1.1-0.9-1.0-1.1-1.0-1.2-1.21.4-0.1
Number of licking bursts0.50.82.00.7-0.60.81.01.00.80.90.71.4-1.20.4
Context. condit. distance diff. score0.50.61.50.3-0.50.71.00.90.70.90.90.70.61.2
Locomotion velocity, session 11.61.73.2-1.20.3-1.5-1.5-1.8-1.4-1.5-1.6-1.5-0.0-0.8
Locomotion distance, session 10.00.10.10.10.40.10.2-0.20.20.1-0.0-0.30.30.3
Locomotion velocity, session 20.80.94.70.4-1.00.50.40.80.70.60.51.3-2.2-0.4
Locomotion distance, session 20.10.10.60.70.80.20.2-0.20.20.0-0.10.0-0.2-0.3
Locomotion velocity, session 30.80.94.00.40.80.80.80.10.50.50.5-0.82.01.5
Locomotion distance, session 31.51.72.9-1.7-1.0-1.5-1.3-1.6-1.5-1.4-1.4-1.20.20.2
Stereotopy head waving bouts, day 31.61.811.61.83.40.5-0.0-0.20.1-0.0-0.2-1.01.7-1.0
Stereotopy head waving duration, day 31.72.06.91.92.61.51.10.81.01.00.9-0.32.00.4
Locomotion velocity, session 70.50.62.6-0.2-1.6-0.10.70.50.30.30.50.9-1.10.6
Locomotion distance, session 70.70.93.8-0.8-1.9-0.8-0.4-0.2-0.5-0.5-0.40.7-2.0-0.5
Stereotopy head waving bouts, day 70.20.20.40.4-0.10.60.70.40.60.50.50.5-0.20.7
Stereotopy head waving duration, day 73.84.67.71.7-0.22.62.82.32.52.52.51.40.92.6
Locomotion velocity, session 80.30.30.60.70.10.50.80.50.60.60.60.6-0.00.5
Locomotion distance, session 80.10.10.20.4-0.10.20.40.30.30.30.30.5-0.10.3
Degree of sensitization distance0.90.92.21.0-0.20.60.71.30.80.80.91.5-1.2-0.7
Degree of sensitization stereotypy1.82.02.80.8-1.21.41.71.41.61.51.51.7-0.81.5
Conditioned locomotion0.20.20.9-0.3-0.9-0.40.20.30.20.20.30.4-0.60.2
Cocaine response after cond. corrected0.70.81.3-1.0-0.2-1.1-1.0-1.1-1.1-1.1-0.9-1.10.2-0.4
Cocaine response after cond. not corrected0.81.01.9-1.4-0.9-1.2-1.0-1.0-1.1-1.1-1.0-0.9-0.3-0.2
Cocaine response before conditioning0.50.62.4-0.3-1.50.10.20.80.40.50.41.1-1.30.3
Saline control response0.30.41.60.80.4-0.00.10.40.40.20.20.6-1.1-1.3
Bone: connectivity density0.81.32.31.2-0.31.31.11.31.21.21.21.5-1.4-0.1
Bone: cortical apparent density1.11.45.51.82.10.3-0.2-0.10.1-0.2-0.40.2-1.6-2.3
Bone: cortical area0.50.82.8-0.7-0.7-0.7-0.9-0.4-0.8-0.7-0.60.2-1.7-1.5
Bone: cortical porosity3.03.39.5-3.1-2.3-2.1-1.8-1.6-1.9-1.7-1.6-1.30.40.6
Bone: cortical porosity3.74.011.1-3.3-2.4-2.4-2.0-1.8-2.1-1.9-1.8-1.40.40.3
Bone: cortical thickness0.40.73.9-0.2-0.3-0.3-0.5-0.3-0.5-0.5-0.40.6-2.0-1.4
Bone: cortical thickness0.70.81.4-0.70.1-1.2-1.1-1.0-1.0-1.1-1.0-0.50.0-1.1
Bone: cortical tissue density1.11.55.31.92.10.4-0.2-0.00.2-0.1-0.30.3-1.5-2.3
Condit. Reinf. active minus inactive responses1.82.03.3-1.2-0.0-1.8-1.7-1.6-1.6-1.7-1.5-1.0-0.5-1.6
Condit. Reinf. active-inactive response ratio0.70.71.1-0.60.4-1.1-1.0-1.0-1.0-1.0-0.8-0.80.3-0.9
Condit. Reinf. active responses1.82.24.1-1.4-0.6-2.0-1.7-1.6-1.7-1.7-1.5-0.6-1.1-1.7
Condit. Reinf. inactive responses0.60.71.4-0.8-0.7-1.2-0.9-0.8-0.9-0.9-0.8-0.0-1.1-0.9
Incentive salience index mean1.31.62.6-1.1-0.4-1.6-1.5-1.4-1.4-1.4-1.3-0.6-1.0-1.4
Condit. Reinf. lever presses0.40.51.2-0.4-0.3-1.0-0.8-0.6-0.7-0.7-0.7-0.0-1.1-0.8
Condit. Reinf. active minus inactive responses2.22.97.4-2.7-2.2-1.9-1.7-1.7-1.8-1.8-1.6-0.8-1.00.2
Condit. Reinf. active-inactive response ratio1.72.06.7-2.6-2.2-1.3-1.2-1.2-1.4-1.3-1.0-0.8-0.30.9
Condit. Reinf. active responses2.02.75.1-2.2-1.6-2.1-1.9-1.6-1.8-1.8-1.6-0.7-1.2-0.6
Condit. Reinf. inactive responses0.50.61.7-0.4-0.0-1.1-1.0-0.5-0.7-0.8-0.9-0.1-0.8-1.3
Condit. Reinf. lever presses1.21.62.8-1.00.4-1.7-1.5-1.6-1.5-1.5-1.4-1.30.3-1.0
Condit. Reinf. lever reinforcers received1.92.75.6-2.4-1.8-2.1-1.8-1.6-1.8-1.8-1.6-0.7-1.0-0.3
Conditioned reinforcement - actives0.50.82.61.61.30.90.80.90.90.90.90.20.4-0.2
Conditioned reinforcement - inactives0.50.83.1-0.5-0.2-1.1-1.5-0.1-0.6-0.6-0.30.2-0.7-1.8
Conditioned locomotion5.36.813.33.62.63.12.72.83.03.13.01.11.00.8
Patch foraging indifference point 0 sec0.51.04.61.00.6-0.4-0.4-0.20.0-0.2-0.50.8-1.9-2.2
Patch foraging indifference point AUC0.20.31.9-0.6-0.90.40.30.1-0.00.10.30.30.11.4
Delay disc. indifference point, 0s delay0.91.01.61.20.51.31.21.01.21.11.20.80.20.7
Delay disc. indifference point, 16s delay0.40.40.90.60.10.80.50.90.80.80.90.6-0.20.3
Delay disc. indifference point, 2s delay2.93.25.51.60.62.32.02.01.92.12.31.40.81.7
Delay disc. indifference point, 24s delay0.70.81.81.0-0.10.80.41.00.80.70.81.3-1.4-0.6
Delay disc. indifference point, 4s delay0.70.71.31.00.41.21.10.81.11.01.00.30.00.7
Delay disc. indifference point, 8s delay0.50.61.00.4-0.70.70.60.90.90.90.80.7-1.00.4
Indifference point function ln k0.40.62.81.41.70.00.30.30.60.40.0-0.20.3-1.2
Indifference point function log k0.40.62.81.41.70.00.30.30.60.40.0-0.20.3-1.2
Patch foraging total patch changes 0 sec0.40.84.20.90.9-0.4-0.5-0.4-0.1-0.3-0.60.4-1.5-2.0
Patch foraging total patch changes 12 sec0.10.10.3-0.10.5-0.2-0.2-0.6-0.4-0.4-0.4-0.30.2-0.0
Patch foraging total patch changes 18 sec0.10.20.50.70.50.0-0.00.00.0-0.00.20.5-0.5-0.6
Patch foraging total patch changes 24 sec0.20.41.0-0.00.8-0.5-0.8-0.7-0.6-0.7-0.6-0.4-0.1-1.0
Patch foraging total patch changes 6 sec0.50.81.71.20.00.81.10.90.90.80.71.3-1.1-0.1
Patch foraging time to switch 0 sec0.30.51.0-0.9-0.5-0.9-0.5-0.8-1.0-0.9-0.7-0.60.60.1
Patch foraging water rate 0 sec0.71.42.20.9-0.41.51.31.21.41.41.21.4-0.90.8
Patch foraging water rate 12 sec0.20.31.00.71.00.70.30.40.60.60.7-0.00.60.2
Patch foraging water rate 18 sec0.30.51.2-0.60.7-0.7-0.5-0.9-0.7-0.7-0.9-1.10.8-0.0
Patch foraging water rate 24 sec0.30.42.1-0.1-0.60.60.70.40.40.50.70.30.21.4
Patch foraging water rate 6 sec1.31.83.81.91.41.81.21.21.61.51.51.1-0.30.1
Seeking ratio, delayed vs. immediate footshock0.40.51.5-0.50.2-0.1-0.0-1.1-0.3-0.5-1.0-1.21.00.9
Distance traveled before self-admin0.20.31.0-1.0-0.80.1-0.20.20.00.10.1-0.60.50.9
Distance traveled after self-admin0.30.41.0-0.1-0.60.60.21.00.70.70.90.5-0.30.4
Extensor digitorum longus weight1.14.49.03.00.62.31.82.32.22.12.22.6-2.1-0.7
Bone: elastic displacement0.50.62.40.41.5-0.5-0.6-0.8-0.5-0.5-0.5-0.80.3-1.3
Bone: elastic work0.40.51.3-0.5-0.0-1.0-0.8-0.6-0.7-0.7-0.7-0.4-0.6-1.2
Bone: endosteal estimation0.51.03.4-1.8-1.2-1.1-1.1-0.7-0.9-0.8-0.8-0.90.50.2
Bone: endosteal perimeter0.20.41.2-1.1-0.5-0.5-0.7-0.2-0.4-0.4-0.4-0.80.70.2
Epididymis fat weight0.72.56.71.1-0.91.41.41.92.11.71.01.6-2.6-0.1
Delta time in closed arm before/after self-admin1.71.62.91.0-0.61.41.21.51.41.51.41.7-1.20.5
Delta time in open arm before/after self-admin1.71.63.9-1.30.5-1.2-1.3-1.2-1.2-1.3-1.1-1.92.00.2
Diff in mean of infusions in LGA sessions1.11.33.51.81.91.20.70.91.01.11.10.31.0-0.1
Delay discount exponential model param1.01.22.0-1.1-0.1-1.4-1.1-1.3-1.3-1.3-1.4-0.90.2-0.8
Extinction: sum of active levers before priming0.30.31.20.81.10.30.20.20.40.3-0.1-0.60.7-0.5
Active lever presses in extinction session 60.10.10.1-0.3-0.2-0.2-0.1-0.3-0.3-0.3-0.2-0.10.10.2
Bone: final force0.40.62.4-1.5-1.3-0.5-0.9-0.5-0.7-0.5-0.6-0.5-0.30.2
Bone: final moment0.30.51.8-1.3-1.0-0.4-0.8-0.4-0.6-0.4-0.5-0.5-0.20.1
Food consumed during 24 hour testing period0.50.73.6-1.00.2-0.2-0.4-0.2-0.5-0.4-0.3-1.01.91.0
Glucose0.91.32.41.2-0.21.51.21.31.51.31.11.3-0.80.5
Heart weight2.13.35.3-1.21.1-1.8-2.0-2.3-2.0-2.1-2.2-2.00.0-1.8
Delay discount hyperbolic model param1.21.32.3-1.00.0-1.5-1.2-1.4-1.3-1.4-1.5-0.90.2-1.0
Intermittent access intake day 1-15 change0.40.93.91.02.00.70.30.30.70.50.5-0.91.6-0.1
Intermittent access intake escalation0.30.73.30.91.80.50.10.30.50.40.4-0.71.3-0.3
Intermittent access intake escalation 21.31.55.01.12.21.20.80.61.00.90.9-1.12.00.6
Intermitt. access day 1 inactive lever presses0.72.67.1-0.60.7-2.1-2.2-1.4-1.7-1.8-1.6-0.6-0.0-2.7
Intermitt. access day 15 inactive lever presses0.30.51.8-0.60.6-1.0-1.2-0.1-0.4-0.5-0.3-0.40.5-1.3
Intermitt. access escalation Index0.10.10.70.20.5-0.3-0.40.2-0.1-0.1-0.1-0.30.2-0.8
Intermittent access day 1 total infusions0.60.92.1-0.7-0.4-1.4-0.9-1.2-1.3-1.3-1.0-0.50.3-0.5
Intermittent access day 15 total infusions0.20.41.31.11.0-0.2-0.20.30.10.00.40.20.2-1.1
Intermittent access terminal intake (last 3 days)0.50.62.81.41.70.10.10.20.30.20.4-0.31.0-0.8
Intermittent access total infusions0.20.20.60.70.6-0.5-0.3-0.0-0.2-0.30.1-0.10.5-0.8
Intermittent access day 1 locomotion0.30.31.20.30.3-0.8-0.6-0.5-0.5-0.6-0.40.1-0.3-1.1
Intermittent access day 15 total locomotion0.61.22.71.61.41.11.01.11.01.11.30.20.90.1
Intermittent access total locomotion1.51.86.42.51.81.21.21.21.31.21.50.50.8-0.2
Intermittent access standard deviation0.40.82.60.21.6-0.5-0.7-0.5-0.4-0.6-0.3-1.11.6-0.6
Left kidney weight0.41.72.61.2-0.11.61.61.51.61.61.31.3-0.60.8
Right kidney weight0.73.15.71.1-1.41.61.82.12.01.91.62.4-2.00.9
Cocaine induced anxiety0.10.20.5-0.10.2-0.5-0.5-0.4-0.4-0.3-0.3-0.70.6-0.2
Post-drug Anxiety0.30.30.60.80.30.60.60.80.70.70.80.10.50.2
Baseline Anxiety1.11.32.41.2-0.01.31.41.51.31.31.51.1-0.40.5
Tail length1.24.723.2-3.8-4.8-1.5-1.1-0.8-1.2-0.9-1.3-0.3-1.71.8
Length with tail1.35.827.4-4.1-5.2-2.0-1.6-0.8-1.2-1.1-1.6-0.6-2.21.3
Length without tail0.82.614.2-1.5-3.80.20.61.10.90.90.51.1-2.21.6
Times rat made contact with spout1.72.03.7-1.40.7-1.1-1.9-1.4-1.5-1.5-1.6-1.91.1-1.0
Lifetime Intake0.10.10.40.60.5-0.2-0.10.10.0-0.00.20.10.4-0.6
Liver weight, left2.94.87.9-2.40.2-2.6-2.4-2.5-2.3-2.3-2.6-2.81.3-0.9
Liver weight, right1.52.74.4-0.71.7-1.8-1.6-2.0-1.6-1.8-2.1-1.80.9-1.5
Locomotor activity0.40.63.10.50.9-0.9-0.8-0.2-0.3-0.4-0.5-0.1-0.3-1.8
Locomotor testing distance0.40.83.20.00.7-1.2-1.1-0.6-0.7-0.8-0.7-0.1-0.3-1.8
Locomotor testing rearing0.30.52.0-0.00.6-0.8-0.8-0.6-0.6-0.6-0.8-0.2-0.4-1.4
Locomotion in novel chamber0.50.61.61.01.30.90.90.10.70.60.1-0.71.00.4
Locomotion in novel chamber post-restriction0.20.31.00.8-0.20.40.30.30.40.40.30.9-1.0-0.5
Fecal boli incidents, locomotor time 10.20.31.4-1.2-1.0-0.5-0.4-0.0-0.2-0.1-0.3-0.50.30.3
Change in fecal boli incidents, locomotor task0.30.30.80.30.9-0.4-0.5-0.6-0.5-0.5-0.3-0.60.3-0.6
Time >=10cm from walls, locomotor time 14.24.47.2-1.80.7-2.5-2.6-2.5-2.7-2.7-2.2-1.50.1-2.0
Bouts of movement, locomotor time 12.62.95.5-1.00.4-2.2-2.3-1.7-1.8-2.0-1.8-1.3-0.4-2.3
Total resting periods, locomotor time 13.23.56.9-1.00.6-2.4-2.6-1.9-2.0-2.2-2.0-1.3-0.4-2.6
Rest time, locomotor task time 12.02.54.8-1.20.3-2.0-2.1-1.3-1.4-1.7-1.7-1.7-0.4-2.2
Distance moved, locomotor task time 11.11.62.50.6-1.41.31.61.01.11.21.11.6-1.11.6
Vertical activity count, locomotor time 10.30.71.80.6-0.61.01.20.40.50.60.51.3-0.41.1
Time >=10cm from walls, locomotor time 20.60.91.3-1.00.4-1.0-1.0-1.0-1.1-1.0-0.8-1.11.1-0.3
Bouts of movement, locomotor time 20.40.63.21.00.9-0.1-0.40.20.30.00.10.5-1.0-1.8
Total resting periods, locomotor time 20.50.85.00.61.0-0.7-1.0-0.3-0.2-0.5-0.6-0.2-0.9-2.2
Rest time, locomotor task time 22.83.56.8-1.20.4-2.1-2.1-2.3-1.9-2.1-2.6-1.5-0.7-2.2
Distance moved, locomotor task time 21.61.93.21.1-0.81.51.51.81.51.71.81.2-0.51.2
Vertical activity count, locomotor time 21.82.53.91.80.71.91.82.01.92.01.91.10.60.9
Light reinforcement 10.82.03.81.51.21.91.81.31.51.51.50.51.10.9
Light reinforcement 20.40.62.4-0.9-0.60.20.30.10.20.30.3-0.61.41.6
Bone: marrow area0.40.93.1-1.8-1.3-1.1-1.0-0.6-0.8-0.7-0.8-0.70.30.1
Bone: maximum diameter0.61.01.7-1.2-0.5-1.2-1.3-0.8-1.1-1.1-1.0-0.6-0.8-1.3
Bone: maximum force0.20.31.4-1.2-1.0-0.2-0.4-0.1-0.3-0.1-0.1-0.40.40.6
Bone: maximum moment0.10.20.8-0.9-0.80.0-0.30.0-0.10.10.1-0.30.50.6
Mean time between licks in bursts0.20.52.71.11.2-0.2-0.30.20.10.1-0.1-0.0-0.4-1.6
Mean num. licks in bursts1.42.14.5-1.21.0-1.4-1.8-1.5-1.4-1.5-1.4-2.11.4-1.0
Cd content in liver0.60.73.70.40.70.90.60.50.40.50.7-0.31.90.8
Co content in liver0.00.10.2-0.10.40.2-0.3-0.10.0-0.0-0.2-0.30.3-0.4
Cu content in liver1.11.35.00.5-1.40.40.71.10.90.80.71.8-2.2-0.2
Fe content in liver1.62.03.2-1.40.2-1.6-1.8-1.7-1.6-1.6-1.7-1.4-0.0-1.1
K content in liver1.31.22.50.9-0.80.81.01.21.21.20.91.6-1.50.2
Mg content in liver0.90.92.20.8-0.70.60.81.01.01.00.81.4-1.5-0.1
Mn content in liver0.40.52.41.41.50.30.30.20.50.40.3-0.10.1-0.6
Na content in liver0.10.10.8-0.4-0.9-0.40.10.00.10.10.00.3-0.30.3
Rb content in liver0.40.52.40.50.8-0.2-0.4-0.3-0.2-0.4-0.40.0-1.0-1.5
Se content in liver0.20.21.30.2-0.2-0.3-0.20.20.20.1-0.10.4-1.1-0.7
Sr content in liver3.93.44.9-1.11.3-2.0-2.2-2.2-2.0-2.2-2.2-2.00.2-1.9
Zn content in liver0.60.61.50.7-0.60.50.51.00.90.90.61.1-1.2-0.3
Bone: minimum diameter0.61.23.2-1.8-1.5-1.1-1.2-0.6-1.1-0.9-0.9-0.4-0.9-0.5
Time in familiar zone, hab. session 11.91.82.61.61.41.61.51.31.41.31.60.51.41.0
Time in novel zone, hab. session 14.94.97.7-2.8-1.0-2.6-2.5-2.6-2.6-2.5-2.7-2.0-0.2-1.0
Total zone transitions, hab. session 10.60.94.3-0.8-2.1-0.50.20.0-0.2-0.10.11.1-1.70.4
Total locomotion distance, hab. session 10.71.01.9-1.3-1.3-1.4-0.9-1.0-1.1-1.1-0.9-0.2-0.9-0.4
Locomotion velocity, hab. session 10.60.92.9-1.1-1.7-1.1-0.6-0.5-0.8-0.7-0.60.4-1.4-0.4
Time in familiar zone, hab. session 20.70.72.30.30.10.71.10.70.50.60.90.11.41.5
Time in novel zone, hab. session 20.80.82.8-0.20.3-0.8-1.1-0.8-0.6-0.7-0.9-0.3-1.1-1.7
Total zone transitions, hab. session 20.00.00.1-0.20.1-0.3-0.1-0.1-0.1-0.1-0.3-0.30.2-0.0
Total locomotion distance, hab. session 20.10.10.4-0.10.3-0.3-0.3-0.1-0.2-0.2-0.3-0.2-0.0-0.6
Locomotion velocity, hab. session 20.00.00.2-0.00.1-0.2-0.20.0-0.0-0.1-0.1-0.0-0.1-0.4
Novel to familiar place preference ratio0.60.63.8-0.9-2.00.00.10.20.20.20.30.7-0.71.0
Novelty place preference0.50.53.1-0.9-1.8-0.00.00.10.10.10.20.4-0.50.9
Time in novel zone, NPP test0.50.53.4-1.1-1.9-0.10.00.0-0.00.00.10.3-0.31.1
Total zone transitions, NPP test0.00.00.0-0.2-0.1-0.2-0.1-0.20.00.0-0.2-0.1-0.10.0
Total locomotion distance, NPP test0.10.20.4-0.4-0.2-0.6-0.4-0.5-0.4-0.4-0.4-0.2-0.2-0.4
Locomotion velocity, NPP test0.10.10.2-0.00.1-0.4-0.2-0.4-0.2-0.2-0.3-0.0-0.3-0.5
Intraocular pressure0.50.72.01.41.40.80.80.60.70.60.50.20.9-0.1
Delta distance traveled before/after self-admin0.50.51.00.90.30.50.40.90.60.60.81.0-0.9-0.7
Delta ambulatory time before/after self-admin0.30.31.10.50.10.0-0.00.50.20.10.40.9-1.0-1.0
Parametrial fat weight0.40.84.1-1.0-2.0-0.6-0.10.60.10.1-0.21.1-1.50.0
Pavlov. Cond. lever latency0.91.26.6-0.01.7-0.0-0.1-0.7-0.5-0.5-0.4-1.42.60.4
Pavlov. Cond. magazine entry latency0.70.84.9-1.1-2.2-0.4-0.10.2-0.10.10.20.7-1.30.8
Pavlov. Cond. change in total contacts2.12.25.10.4-2.10.91.21.41.21.21.42.1-2.30.9
Pavlov. Cond. index score0.70.94.1-0.5-2.0-0.3-0.00.50.20.30.31.0-2.00.2
Pavlov. Cond. latency score0.70.83.8-0.5-2.0-0.3-0.10.40.10.20.31.0-2.00.1
Pavlov. Cond. lever contacts0.70.95.10.3-1.20.10.10.60.40.40.41.3-2.3-0.6
Pavlov. Cond. magazine entry number0.60.83.70.61.90.1-0.2-0.4-0.3-0.3-0.4-1.01.6-0.6
Pavlov. Cond. intertrial magazine entries0.91.13.60.11.3-0.8-1.0-1.1-0.9-1.0-1.2-0.8-0.2-1.9
Pavlov. Cond. lever-magazine prob. diff.0.60.83.4-0.4-1.8-0.20.10.50.30.30.41.0-1.80.2
Pavlov. Cond. response bias0.70.95.2-0.6-1.9-0.5-0.20.20.10.00.00.9-2.3-0.2
Pavlov. Cond. lever latency1.52.13.81.2-0.51.91.61.81.81.71.51.5-0.90.7
Pavlov. Cond. magazine entry latency1.21.43.7-0.51.0-1.3-0.8-1.4-1.1-1.1-0.9-1.71.90.0
Pavlov. Cond. change in total contacts1.32.03.9-1.30.2-2.0-1.4-1.9-1.7-1.7-1.6-1.60.5-0.4
Pavlov. Cond. index score2.83.76.1-1.41.0-2.4-1.9-2.5-2.2-2.2-2.0-2.31.6-0.9
Pavlov. Cond. latency score2.22.94.7-1.30.8-2.2-1.7-2.2-2.0-1.9-1.7-2.11.5-0.6
Pavlov. Cond. lever contacts2.23.05.3-1.60.4-2.3-1.9-2.1-2.1-2.1-1.8-1.80.9-0.8
Pavlov. Cond. magazine entry number2.32.85.50.8-1.51.81.42.11.71.81.72.4-1.80.7
Pavlov. Cond. intertrial magazine entries3.55.212.61.3-2.12.11.92.72.22.32.33.5-2.80.6
Pavlov. Cond. lever-magazine prob. diff.2.93.96.3-1.31.3-2.4-1.9-2.5-2.2-2.2-2.0-2.41.7-0.9
Pavlov. Cond. response bias3.04.16.8-1.61.0-2.6-2.1-2.6-2.3-2.3-2.2-2.41.4-1.0
Time in closed arm before self-admin2.73.45.3-2.2-0.2-2.2-1.9-2.1-2.0-2.1-2.1-2.31.3-0.3
Time in closed arm after self-admin0.20.20.9-0.8-0.9-0.3-0.2-0.4-0.3-0.3-0.4-0.2-0.40.4
Time in open arm before self-admin1.92.14.62.20.81.20.91.11.11.11.12.1-2.0-1.5
Time in open arm after self-admin0.80.81.4-0.60.7-0.9-1.1-0.9-1.0-1.0-0.9-1.21.0-0.6
Bone: periosteal estimation0.51.12.9-1.7-1.4-1.1-1.2-0.6-1.0-0.9-0.9-0.3-0.8-0.7
Bone: periosteal perimeter0.50.91.7-1.3-0.1-1.0-1.2-0.9-1.1-1.0-1.0-1.20.3-0.7
Bone: post-yield work0.30.52.60.00.20.50.60.30.40.60.6-0.41.61.1
Progressive ratio test 1 active lever presses0.91.13.40.20.4-1.4-1.1-1.1-1.1-1.2-1.3-0.2-0.2-1.9
Progressive ratio test 1 breakpoint0.81.02.60.10.1-1.4-1.0-1.1-1.1-1.1-1.3-0.2-0.3-1.6
Progressive ratio test 1 inactive lever presses0.81.17.30.40.5-1.2-1.1-0.2-0.5-0.6-0.80.3-0.8-2.7
Progressive ratio test 2 active lever presses0.40.42.10.30.6-0.7-0.9-0.4-0.5-0.6-0.4-0.2-0.1-1.5
Progressive ratio test 2 breakpoint0.50.52.20.20.5-0.9-1.0-0.5-0.6-0.7-0.6-0.3-0.1-1.5
Progressive ratio test 2 inactive lever presses0.50.93.60.61.6-0.7-1.0-0.2-0.3-0.4-0.4-0.70.6-1.9
Incentive Sensitization - Responses0.10.20.60.00.7-0.3-0.7-0.1-0.2-0.20.0-0.40.3-0.7
Incentive Sensitization - Breakpoint0.10.20.5-0.00.7-0.3-0.7-0.1-0.2-0.3-0.1-0.40.3-0.7
Sum of active levers in priming session hrs 5-60.30.21.2-0.5-1.1-0.3-0.40.1-0.1-0.1-0.30.2-0.9-0.1
Progressive ratio1.01.63.5-0.60.0-1.5-1.1-1.6-1.2-1.5-1.7-0.5-0.9-1.9
Food seeking constrained by brief footshock2.02.54.12.00.81.81.91.81.91.91.81.4-0.00.5
Seeking ratio, punishment vs. effort2.73.97.11.4-0.12.32.02.62.12.52.71.30.62.2
Retroperitoneal fat weight0.72.95.01.2-1.31.51.62.22.11.91.32.2-1.90.6
Reaction time number correct0.20.42.20.91.50.50.20.20.30.20.5-0.00.5-0.5
Reaction time mean minus median0.10.20.7-0.60.3-0.1-0.3-0.4-0.1-0.3-0.4-0.80.80.4
Reaction time mean minus median AUC0.20.41.2-0.70.4-0.2-0.5-0.5-0.4-0.5-0.5-1.11.10.3
Reaction time num false alarms1.42.04.72.20.71.61.61.71.81.61.31.3-0.4-0.2
Reaction time num false alarms AUC1.11.73.81.90.51.41.41.51.71.41.11.2-0.6-0.1
Reaction time trials correct on left0.20.42.20.91.50.50.20.20.30.20.5-0.00.5-0.5
Reaction time trials on left0.20.42.00.91.40.50.20.20.30.20.5-0.00.5-0.4
Reaction time mean2.64.16.6-2.6-0.7-2.4-2.5-2.2-2.3-2.2-2.3-2.00.2-1.0
Reaction time mean AUC1.93.15.7-2.4-1.0-2.1-2.1-1.8-2.0-2.0-2.0-1.5-0.1-0.8
Median of all reaction times3.95.68.5-2.9-1.1-2.9-2.9-2.5-2.7-2.6-2.7-2.0-0.4-1.5
Reaction time omissions0.10.20.7-0.8-0.7-0.5-0.4-0.1-0.2-0.2-0.4-0.40.10.4
Reaction time false alarm rate0.91.32.21.2-0.71.11.31.51.51.30.91.3-0.90.3
Reaction time premature initiation rate0.60.81.1-0.51.1-0.7-1.0-0.9-0.9-0.9-1.0-1.10.9-0.7
Reaction time premature initiations0.50.93.60.01.9-0.3-0.8-0.8-0.7-0.7-0.6-1.11.3-0.8
Std. dev. reaction times0.61.12.8-1.7-0.4-0.9-1.0-1.1-1.0-1.0-1.2-1.30.90.4
Reaction time trials completed0.20.42.00.91.40.50.20.20.30.20.5-0.00.5-0.4
Reaction time trials AUC0.20.31.90.81.40.40.10.10.20.10.4-0.10.5-0.5
Run reversals in cocaine runway, females0.40.41.6-0.0-0.80.40.30.60.00.20.81.3-0.60.4
Run reversals in cocaine runway, males0.30.31.7-0.4-0.80.60.40.20.40.40.20.1-0.31.3
Latency to leave start box in cocaine runway1.11.23.41.81.00.70.40.20.90.6-0.10.9-1.7-1.8
Latency to leave start box in cocaine runway, F0.91.03.01.70.61.00.70.51.00.80.11.3-1.4-1.2
Latency to leave start box in cocaine runway, M0.50.51.70.81.2-0.1-0.3-0.60.1-0.2-0.4-0.4-0.6-1.3
Std. dev. time between licks in bursts1.01.34.72.21.10.71.11.01.11.11.11.3-0.6-0.6
Total sessions with >9 infusions0.30.41.50.00.7-0.5-0.8-0.7-0.6-0.7-0.6-0.2-0.1-1.2
Short access day 1 total inactive lever presses0.60.81.51.20.40.80.91.11.11.01.11.0-0.2-0.1
Short access day 10 total inactive lever presses0.30.72.0-0.8-0.1-1.2-1.3-0.3-0.8-0.8-0.7-0.2-0.3-1.4
Short access day 1 total infusions0.30.40.80.90.80.60.30.90.70.60.90.50.1-0.6
Short access day 10 total infusions0.20.31.00.1-0.1-1.0-0.4-0.4-0.6-0.6-0.40.30.1-0.8
Short access total infusions0.10.20.60.70.80.10.10.20.20.20.30.30.2-0.6
Short access day 1 locomotion0.50.62.5-0.0-0.0-0.9-1.0-0.4-0.6-0.7-0.50.0-1.0-1.6
Short access day 10 total locomotion0.30.61.60.21.3-0.8-0.7-0.7-0.6-0.7-0.5-0.60.9-1.2
Short access total locomotion0.30.31.31.11.10.1-0.00.00.20.10.30.3-0.1-0.9
One hour access (0.3 mA shock)0.10.20.70.40.9-0.2-0.2-0.3-0.1-0.2-0.2-0.50.6-0.4
Compulsive drug intake0.70.81.8-0.20.2-1.1-0.9-1.0-1.1-1.1-1.20.0-0.2-1.3
One hour access (shock baseline)0.10.10.50.10.10.10.20.30.30.30.4-0.50.70.5
Social response proportion0.30.30.80.1-0.80.10.50.90.70.60.50.7-0.40.2
Social responses0.10.10.4-0.6-0.6-0.7-0.1-0.2-0.2-0.3-0.4-0.00.20.1
Social time0.20.30.7-0.20.6-0.6-0.6-0.5-0.6-0.6-0.4-0.90.7-0.2
Soleus weight0.10.20.40.30.10.60.20.30.50.50.5-0.00.60.6
Bone: stiffness0.20.41.2-0.9-1.10.20.10.40.20.30.2-0.30.61.1
Tibialis anterior weight0.41.32.61.40.31.61.11.41.31.31.61.0-0.20.3
Time to tail flick, vehicle, before self-admin0.40.40.8-0.8-0.2-0.8-0.8-0.7-0.9-0.8-0.6-0.10.1-0.3
Time to tail flick, vehicle, after self-admin1.11.42.2-1.5-0.4-1.5-1.2-1.3-1.3-1.3-1.4-1.50.5-0.2
Time to tail flick, test, before self-admin0.60.62.3-1.2-1.5-0.7-0.3-0.4-0.6-0.6-0.40.2-0.40.7
Time to tail flick, test, after self-admin2.62.76.12.52.31.91.71.41.71.71.50.51.30.3
Delta time to tail flick, vehicle, before/after SA0.30.21.20.10.60.10.30.00.20.10.1-0.91.10.5
Delta time to tail flick, test, before/after SA2.72.811.42.73.41.51.10.91.51.31.0-0.31.6-0.8
Tibia length0.51.44.8-2.2-2.2-0.9-0.9-0.7-1.0-0.8-1.0-0.4-1.10.3
Ambulatory time before self-admin0.40.62.3-0.7-0.60.60.30.60.50.60.6-0.51.01.5
Ambulatory time after self-admin0.40.51.60.3-0.30.70.31.20.90.81.00.8-0.5-0.1
Bone: tissue strength1.71.73.80.4-0.91.71.51.31.41.51.51.00.12.0
Total heroin consumption0.40.51.1-0.8-0.2-0.9-0.9-0.4-0.5-0.5-0.8-1.00.6-0.4
Bone: trabecular number0.61.01.70.5-0.71.21.21.11.01.21.20.9-0.11.3
Bone: trabecular spacing1.11.52.5-1.0-0.3-1.5-1.6-1.3-1.2-1.3-1.4-0.6-0.8-1.6
Bone: trabecular thickness0.50.73.0-0.7-0.70.60.50.20.20.30.6-0.21.41.7
Bone: trabecular tissue density3.34.86.9-1.21.6-2.2-2.6-2.5-2.3-2.5-2.6-2.30.3-2.6
Water consumed over 24 hours0.10.20.5-0.20.6-0.3-0.5-0.2-0.4-0.4-0.3-0.50.7-0.3
Number of responses in last shaping day0.91.03.3-1.1-1.6-0.9-0.7-0.5-0.6-0.6-0.80.3-1.8-0.8