Hub : Genes

Cpne3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Cpne3 0.09 0.04 1.1e-16 0.1 0.12 0.13 0.13 3.4e-15 1.4e-17 2.0e-19 3.2e-19
2 PL gene expression Cpne3 0.04 0.03 5.2e-04 0.01 0.02 0.01 0.01 2.1e-02 3.9e-03 1.3e-02 6.2e-02
3 Brain gene expression Cpne3 0.19 0.08 0.0e+00 0.16 0.17 0.17 0.16 6.3e-15 8.6e-16 2.8e-15 1.1e-14
4 Brain mRNA stability Cpne3 0.1 0.05 2.7e-10 0.07 0.1 0.12 0.1 3.0e-07 4.0e-09 1.7e-11 6.9e-10
5 BLA mRNA stability Cpne3 0.25 0.11 7.9e-11 0.16 0.16 0.16 0.16 7.3e-09 1.1e-08 1.4e-08 7.3e-09
6 PL mRNA stability Cpne3 0.09 0.04 2.2e-11 0.12 0.11 0.11 0.11 5.4e-13 6.0e-12 1.1e-11 1.3e-11
7 Adipose mRNA stability Cpne3 0.03 0.02 8.8e-03 0.01 0.01 0.01 0.01 4.0e-02 4.0e-02 5.5e-02 4.1e-02
8 Liver gene expression Cpne3 0.08 0.04 7.5e-08 0.06 0.06 0.05 0.05 7.7e-07 9.1e-07 1.7e-06 2.0e-06
9 NAcc gene expression Cpne3 0.03 0.02 4.3e-04 0.03 0.02 0.02 0.03 7.1e-05 3.6e-04 1.2e-04 7.2e-05
10 Adipose gene expression Cpne3 0.16 0.08 8.1e-11 0.06 0.07 0.06 0.06 1.0e-07 1.1e-08 5.5e-07 2.1e-07
11 Brain intron excision ratio chr5_37829062_37833645 0.03 0.02 7.6e-03 0.02 0.03 0.02 0.02 2.8e-03 1.2e-03 4.8e-03 3.8e-03
12 pVTA gene expression Cpne3 0.08 0.04 4.9e-06 0.03 0.07 0.07 0.06 1.1e-03 3.0e-06 2.2e-06 1.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.71.45.21.71.31.41.50.50.60.4-0.7-2.30.80.7-0.7
Area under the delay curve0.81.33.2-1.8-1.2-1.1-1.0-1.2-1.5-1.60.50.90.70.6-0.2
BMI with tail0.62.29.31.81.61.61.70.40.11.0-0.9-3.00.81.0-1.4
BMI without tail0.31.45.90.61.01.60.4-0.4-0.9-0.7-0.2-2.40.91.3-1.6
Body weight1.67.212.53.53.23.43.32.72.33.2-2.8-2.6-1.6-1.10.7
Weight adjusted by age0.20.61.8-0.00.10.2-0.1-0.7-0.5-0.70.5-1.41.21.2-0.9
Bone surface1.12.25.92.42.21.91.91.21.10.7-1.5-1.80.20.1-0.2
Bone volume0.81.64.02.01.71.61.70.90.80.7-1.2-1.70.30.1-0.3
Breakpoint value in progressive ratio session0.30.51.8-0.8-0.3-0.4-0.7-0.6-0.2-1.41.00.40.50.3-0.7
Number of licking bursts0.20.52.2-0.5-0.5-0.7-0.60.00.30.2-0.11.5-0.7-0.80.9
Context. condit. distance diff. score1.41.73.9-2.0-1.5-0.9-1.8-1.6-1.3-1.31.5-0.10.50.9-1.0
Locomotion velocity, session 12.02.34.42.11.61.41.91.51.71.9-1.6-1.4-0.5-0.60.5
Locomotion distance, session 11.51.93.11.31.21.01.21.51.81.5-1.60.3-1.6-1.51.2
Locomotion velocity, session 20.20.20.7-0.3-0.6-0.8-0.6-0.3-0.30.00.40.50.1-0.10.0
Locomotion distance, session 20.10.10.5-0.1-0.0-0.0-0.60.10.3-0.3-0.30.7-0.3-0.40.2
Locomotion velocity, session 30.60.71.81.11.31.40.80.50.70.4-0.5-1.2-0.2-0.0-0.2
Locomotion distance, session 30.70.82.7-0.20.30.9-0.4-0.8-0.7-1.10.8-1.60.61.1-1.2
Stereotopy head waving bouts, day 30.70.84.6-0.00.40.2-1.00.50.5-1.0-0.92.1-0.7-0.90.8
Stereotopy head waving duration, day 30.20.31.5-0.1-0.1-0.1-0.60.30.3-0.3-0.81.2-0.4-0.50.4
Locomotion velocity, session 70.70.81.4-1.2-1.2-0.9-0.9-1.2-1.1-0.20.6-0.50.50.7-0.7
Locomotion distance, session 70.40.51.0-0.7-0.7-0.2-0.8-0.9-0.8-0.20.6-1.00.40.8-0.7
Stereotopy head waving bouts, day 70.30.31.0-0.8-0.2-0.1-1.0-0.3-0.3-0.9-0.01.0-0.4-0.30.1
Stereotopy head waving duration, day 70.20.30.70.20.50.30.20.40.30.2-0.90.6-0.6-0.70.5
Locomotion velocity, session 80.10.10.5-0.3-0.3-0.4-0.7-0.2-0.0-0.10.10.3-0.1-0.20.0
Locomotion distance, session 80.20.31.6-0.9-0.6-0.3-1.3-0.4-0.1-0.60.20.5-0.3-0.0-0.1
Degree of sensitization distance0.40.41.6-0.4-0.9-1.3-0.5-0.1-0.10.7-0.11.1-0.1-0.50.7
Degree of sensitization stereotypy0.50.61.6-1.3-0.7-0.4-1.1-0.9-0.9-1.00.70.10.20.5-0.5
Conditioned locomotion0.30.30.90.60.1-0.80.70.40.31.0-0.60.50.1-0.60.7
Cocaine response after cond. corrected0.30.52.5-0.8-0.6-0.9-0.8-0.3-0.4-0.50.21.6-0.4-0.70.5
Cocaine response after cond. not corrected0.30.52.2-0.6-0.4-0.6-0.7-0.1-0.2-0.2-0.01.5-0.7-0.90.8
Cocaine response before conditioning0.10.10.70.40.40.8-0.00.10.1-0.0-0.0-0.6-0.30.10.1
Saline control response4.36.012.03.22.92.53.52.52.52.7-2.6-1.3-1.4-1.51.4
Bone: connectivity density0.50.92.41.61.10.71.40.50.60.5-0.6-1.50.80.4-0.3
Bone: cortical apparent density0.50.81.9-0.3-0.6-0.5-0.3-0.8-0.8-0.30.7-1.21.41.3-1.4
Bone: cortical area0.10.20.50.60.50.20.40.1-0.0-0.1-0.2-0.70.70.5-0.7
Bone: cortical porosity1.41.63.50.70.4-0.10.31.21.21.4-0.81.7-1.6-1.91.8
Bone: cortical porosity0.91.02.30.60.40.10.11.11.11.0-0.51.3-1.3-1.51.4
Bone: cortical thickness0.81.32.8-1.1-1.4-1.7-1.1-1.2-1.2-0.81.20.41.30.8-0.8
Bone: cortical thickness0.40.41.2-0.2-0.7-0.80.0-0.5-0.50.20.3-0.71.10.8-1.0
Bone: cortical tissue density0.50.71.8-0.3-0.6-0.4-0.3-0.8-0.7-0.20.7-1.21.31.2-1.3
Condit. Reinf. active minus inactive responses1.11.23.2-1.4-1.2-1.0-1.8-0.9-0.9-1.01.70.40.50.7-0.8
Condit. Reinf. active-inactive response ratio0.20.20.5-0.30.10.2-0.50.20.3-0.10.30.7-0.7-0.50.4
Condit. Reinf. active responses2.12.65.5-1.9-1.9-1.7-2.3-1.4-1.5-1.52.30.51.21.1-1.1
Condit. Reinf. inactive responses2.43.15.0-1.8-2.1-2.0-2.2-1.7-1.8-1.72.00.41.71.5-1.4
Incentive salience index mean0.70.92.8-1.1-1.1-1.1-1.7-0.7-0.7-0.91.40.90.50.4-0.3
Condit. Reinf. lever presses0.20.31.1-0.3-0.7-1.0-0.7-0.5-0.5-0.20.60.30.70.3-0.2
Condit. Reinf. active minus inactive responses0.10.10.5-0.1-0.0-0.10.50.10.20.0-0.40.7-0.1-0.20.3
Condit. Reinf. active-inactive response ratio0.10.20.50.20.2-0.00.70.30.40.3-0.30.7-0.2-0.30.5
Condit. Reinf. active responses0.00.00.2-0.0-0.1-0.10.3-0.10.00.1-0.40.10.10.1-0.2
Condit. Reinf. inactive responses0.10.10.50.30.30.50.10.20.20.4-0.5-0.7-0.20.0-0.3
Condit. Reinf. lever presses0.60.82.81.10.60.31.40.80.81.7-1.1-0.8-0.3-0.30.1
Condit. Reinf. lever reinforcers received0.00.00.2-0.1-0.1-0.10.30.00.10.2-0.50.4-0.1-0.10.0
Conditioned reinforcement - actives0.10.20.8-0.4-0.7-0.5-0.5-0.5-0.4-0.20.9-0.30.40.5-0.3
Conditioned reinforcement - inactives0.20.51.2-0.7-1.1-0.8-0.4-1.1-0.6-0.50.4-0.40.80.9-0.8
Conditioned locomotion1.72.54.1-1.2-1.5-1.2-1.8-1.9-1.6-1.82.0-0.51.71.7-1.4
Patch foraging indifference point 0 sec1.43.98.32.82.52.32.92.01.92.0-1.6-1.9-0.6-0.50.5
Patch foraging indifference point AUC0.51.32.31.01.21.00.71.31.10.7-1.50.7-1.3-1.31.2
Delay disc. indifference point, 0s delay0.20.20.8-0.00.50.60.90.20.1-0.0-0.6-0.0-0.5-0.30.4
Delay disc. indifference point, 16s delay0.50.71.8-1.3-1.1-1.1-0.6-0.7-1.2-0.80.90.90.30.20.3
Delay disc. indifference point, 2s delay0.70.81.9-1.3-0.8-0.9-0.9-0.8-0.9-1.40.71.30.30.10.3
Delay disc. indifference point, 24s delay1.72.64.5-2.1-1.9-1.9-1.7-1.7-2.1-1.61.40.41.41.3-1.3
Delay disc. indifference point, 4s delay0.30.31.0-0.8-0.30.00.1-0.5-1.0-0.5-0.2-0.60.40.6-0.5
Delay disc. indifference point, 8s delay0.91.53.1-1.7-1.3-1.2-1.0-1.4-1.8-1.50.40.21.01.0-0.8
Indifference point function ln k0.00.10.30.40.50.50.60.40.30.1-0.1-0.2-0.0-0.10.1
Indifference point function log k0.00.10.30.40.50.50.60.40.30.1-0.1-0.2-0.0-0.10.1
Patch foraging total patch changes 0 sec1.64.710.23.12.72.63.22.22.12.3-1.8-2.2-0.8-0.60.5
Patch foraging total patch changes 12 sec2.43.37.82.82.21.92.31.81.52.0-1.8-2.1-0.2-0.30.2
Patch foraging total patch changes 18 sec1.73.97.42.22.22.22.72.32.02.2-2.1-0.8-1.7-1.41.1
Patch foraging total patch changes 24 sec0.41.53.21.21.21.51.81.41.31.2-0.9-0.4-1.3-0.91.0
Patch foraging total patch changes 6 sec2.54.37.42.72.62.32.42.42.41.9-2.1-0.4-1.5-1.41.5
Patch foraging time to switch 0 sec0.93.54.9-1.8-2.1-2.1-1.9-2.2-2.0-1.82.0-0.12.11.7-1.5
Patch foraging water rate 0 sec0.93.47.92.21.91.62.52.11.82.8-1.6-1.1-1.3-1.20.9
Patch foraging water rate 12 sec0.41.44.60.90.81.21.71.21.02.1-0.5-0.9-1.4-0.90.5
Patch foraging water rate 18 sec0.20.31.40.60.30.41.00.50.31.2-0.1-0.6-0.5-0.30.3
Patch foraging water rate 24 sec1.72.43.71.61.71.81.71.81.71.7-1.1-0.1-1.9-1.61.3
Patch foraging water rate 6 sec1.72.64.71.61.31.42.01.81.82.2-1.4-0.2-1.8-1.51.3
Seeking ratio, delayed vs. immediate footshock0.50.81.30.50.90.60.50.91.00.0-0.91.1-1.0-1.21.1
Distance traveled before self-admin0.61.33.71.01.11.11.21.31.01.1-1.9-0.1-1.0-0.91.1
Distance traveled after self-admin0.20.41.5-0.10.10.10.40.60.51.2-0.6-0.2-0.9-0.70.8
Extensor digitorum longus weight0.41.82.91.71.71.51.71.41.31.6-1.2-1.0-1.0-0.80.7
Bone: elastic displacement0.40.51.8-0.8-0.7-0.8-1.1-0.2-0.0-0.10.21.4-0.5-0.60.5
Bone: elastic work0.30.41.00.10.20.2-0.30.60.60.5-0.60.9-1.0-0.90.7
Bone: endosteal estimation1.74.214.12.43.03.72.01.51.40.5-1.9-3.0-0.80.1-0.7
Bone: endosteal perimeter1.43.47.42.22.62.72.21.91.71.2-2.1-1.3-1.3-0.90.4
Epididymis fat weight0.10.51.10.90.70.40.90.80.81.0-0.4-0.4-0.3-0.40.3
Delta time in closed arm before/after self-admin0.20.20.8-0.2-0.3-0.30.00.20.00.2-0.20.9-0.5-0.50.7
Delta time in open arm before/after self-admin0.91.01.71.21.10.91.11.11.21.3-0.8-0.2-0.9-0.90.9
Diff in mean of infusions in LGA sessions0.20.30.8-0.10.10.2-0.4-0.5-0.3-0.80.5-0.90.70.7-0.6
Delay discount exponential model param1.01.33.11.81.21.11.11.21.61.7-0.5-0.7-0.9-0.70.4
Extinction: sum of active levers before priming0.30.41.11.00.80.80.50.40.80.30.2-0.90.00.0-0.3
Active lever presses in extinction session 61.01.01.9-1.0-1.0-0.6-0.6-1.1-1.0-0.40.7-1.11.11.3-1.4
Bone: final force0.50.72.51.21.31.60.80.60.40.1-0.7-1.1-0.10.2-0.4
Bone: final moment0.50.83.01.21.41.70.70.60.4-0.0-0.7-1.3-0.00.3-0.6
Food consumed during 24 hour testing period0.91.94.41.71.92.11.21.41.31.0-1.3-1.3-1.1-0.70.3
Glucose0.30.51.0-0.8-0.9-0.8-0.7-0.8-0.8-0.31.0-0.20.70.7-0.6
Heart weight0.10.20.8-0.00.10.20.60.2-0.40.9-0.3-0.3-0.5-0.30.2
Delay discount hyperbolic model param0.81.12.61.61.01.00.91.11.51.5-0.4-0.7-0.7-0.60.3
Intermittent access intake day 1-15 change0.10.40.91.00.70.60.40.70.90.3-0.80.3-0.5-0.60.8
Intermittent access intake escalation0.10.41.21.10.70.70.50.70.70.2-0.8-0.1-0.4-0.50.6
Intermittent access intake escalation 20.10.10.30.50.30.20.10.40.40.0-0.30.5-0.4-0.50.4
Intermitt. access day 1 inactive lever presses0.00.52.6-0.6-0.1-0.2-0.3-0.8-0.8-1.60.30.30.80.6-0.7
Intermitt. access day 15 inactive lever presses0.21.32.3-1.5-1.3-1.3-1.1-1.2-1.1-1.31.40.60.80.8-0.7
Intermitt. access escalation Index0.10.20.50.20.30.1-0.10.50.40.10.10.7-0.6-0.70.7
Intermittent access day 1 total infusions0.20.51.2-0.9-1.1-0.8-0.1-0.8-0.50.20.6-0.90.60.8-0.7
Intermittent access day 15 total infusions0.10.30.8-0.4-0.9-0.6-0.3-0.7-0.5-0.30.3-0.50.60.6-0.4
Intermittent access terminal intake (last 3 days)0.40.81.4-0.8-1.1-0.8-0.5-1.2-1.0-0.50.6-0.81.01.1-0.9
Intermittent access total infusions0.30.30.9-0.4-0.8-0.5-0.1-0.5-0.30.20.6-1.00.60.7-0.6
Intermittent access day 1 locomotion0.81.52.8-1.7-1.6-1.5-1.3-1.5-1.3-1.11.20.40.90.9-0.5
Intermittent access day 15 total locomotion0.31.12.2-1.5-1.4-1.4-1.2-1.0-0.6-1.20.51.50.40.20.4
Intermittent access total locomotion0.91.12.2-1.5-1.5-1.4-1.3-1.2-0.9-1.00.70.80.60.5-0.0
Intermittent access standard deviation0.10.61.6-0.2-0.6-0.30.1-0.9-0.7-0.10.1-1.30.91.2-1.1
Left kidney weight0.43.67.32.12.42.71.62.11.91.8-2.0-0.6-2.0-1.51.1
Right kidney weight0.53.56.22.02.32.51.62.21.81.7-2.0-0.0-2.0-1.61.3
Cocaine induced anxiety0.61.63.9-0.4-0.9-0.4-0.1-1.3-1.1-0.21.5-2.01.51.8-1.9
Post-drug Anxiety0.80.92.2-0.5-0.7-0.3-0.2-1.1-0.9-0.21.2-1.51.01.3-1.2
Baseline Anxiety0.71.13.30.00.50.2-0.10.80.8-0.1-1.21.8-1.3-1.51.8
Tail length0.20.92.00.71.01.30.60.90.80.2-1.00.4-1.4-1.11.0
Length with tail1.77.410.13.12.92.93.03.23.13.0-2.8-0.6-2.6-2.22.1
Length without tail0.73.66.92.41.91.82.52.12.22.6-1.8-0.9-1.4-1.11.0
Times rat made contact with spout2.02.33.81.81.81.91.51.71.81.3-1.5-0.6-1.5-1.21.0
Lifetime Intake0.40.51.2-0.7-1.1-0.8-0.3-0.7-0.40.00.8-0.60.60.7-0.6
Liver weight, left0.40.72.01.31.10.31.41.00.61.0-0.6-0.10.2-0.40.4
Liver weight, right0.50.81.71.31.11.01.11.00.91.0-0.8-0.8-0.4-0.30.2
Locomotor activity0.50.73.01.11.51.70.50.60.5-0.8-0.5-0.4-0.4-0.20.5
Locomotor testing distance1.02.46.61.82.22.61.21.61.70.2-1.4-0.1-1.6-1.11.3
Locomotor testing rearing1.34.78.42.02.52.91.62.42.41.0-2.30.9-2.8-2.22.2
Locomotion in novel chamber0.81.03.01.71.61.40.71.01.20.5-0.8-0.5-0.3-0.40.6
Locomotion in novel chamber post-restriction0.20.71.10.80.90.6-0.11.01.10.5-0.80.9-0.9-1.00.8
Fecal boli incidents, locomotor time 11.74.46.42.52.31.92.22.52.52.1-2.20.2-1.8-1.92.0
Change in fecal boli incidents, locomotor task5.86.29.0-2.7-2.7-2.2-2.4-3.0-2.5-2.82.6-0.42.52.5-2.5
Time >=10cm from walls, locomotor time 12.22.73.9-1.5-1.7-1.3-1.9-1.9-2.0-1.51.8-0.61.51.6-1.9
Bouts of movement, locomotor time 10.60.81.91.31.41.21.10.90.80.2-0.80.1-0.6-0.70.4
Total resting periods, locomotor time 11.11.22.91.61.71.41.41.21.20.5-0.90.0-0.7-0.80.5
Rest time, locomotor task time 10.40.61.81.10.80.91.30.60.80.8-0.3-1.2-0.10.0-0.4
Distance moved, locomotor task time 10.20.62.4-0.7-0.7-0.9-1.5-0.5-0.6-0.80.21.2-0.0-0.20.3
Vertical activity count, locomotor time 10.21.34.3-1.4-1.1-1.1-2.1-1.1-1.2-1.60.41.40.10.00.0
Time >=10cm from walls, locomotor time 20.82.14.1-0.9-1.4-1.2-1.1-1.7-1.3-1.81.4-0.52.01.8-1.6
Bouts of movement, locomotor time 20.31.02.6-0.8-0.8-0.5-0.7-1.1-1.6-0.80.6-0.81.31.3-1.1
Total resting periods, locomotor time 20.10.61.7-0.4-0.4-0.1-0.2-0.7-1.3-0.50.3-1.11.01.1-0.9
Rest time, locomotor task time 20.30.51.60.91.11.30.40.80.50.5-0.4-0.7-0.5-0.3-0.1
Distance moved, locomotor task time 20.30.52.1-0.5-0.6-0.9-0.7-0.5-0.2-0.8-0.31.5-0.1-0.50.5
Vertical activity count, locomotor time 20.71.53.7-1.4-1.2-1.4-1.7-1.5-1.2-1.90.31.50.60.3-0.1
Light reinforcement 10.00.10.60.20.00.20.70.30.30.60.2-0.60.00.20.0
Light reinforcement 20.51.22.6-1.6-1.4-1.4-0.9-1.1-1.3-0.91.30.70.60.6-0.2
Bone: marrow area1.74.214.02.43.03.71.91.41.30.4-1.9-3.0-0.70.1-0.8
Bone: maximum diameter0.30.61.41.01.11.11.00.50.3-0.2-0.7-1.20.40.4-0.6
Bone: maximum force0.40.82.60.91.21.60.50.30.1-0.4-0.3-1.60.30.6-1.0
Bone: maximum moment0.51.03.51.01.31.80.40.20.0-0.5-0.3-1.90.40.8-1.2
Mean time between licks in bursts0.00.10.5-0.30.20.4-0.60.0-0.2-0.7-0.10.5-0.20.0-0.1
Mean num. licks in bursts0.41.24.31.41.31.61.40.70.60.6-0.5-2.10.00.3-0.5
Cd content in liver0.30.30.80.90.90.70.70.60.40.4-0.5-0.8-0.1-0.10.0
Co content in liver4.45.212.92.83.13.62.72.12.11.5-2.2-2.1-1.7-0.90.7
Cu content in liver0.40.52.10.3-0.2-0.61.00.40.01.4-0.40.4-0.5-0.61.1
Fe content in liver0.20.20.9-0.20.20.50.10.40.10.4-0.20.1-0.9-0.60.7
K content in liver0.20.20.40.0-0.4-0.60.40.0-0.00.6-0.30.60.0-0.20.5
Mg content in liver0.20.21.00.4-0.1-0.10.60.0-0.10.8-0.0-1.00.50.4-0.1
Mn content in liver0.40.51.3-0.1-0.6-1.10.1-0.00.11.2-0.41.0-0.4-0.70.9
Na content in liver1.01.23.20.80.40.11.80.91.01.7-0.70.3-0.9-1.11.7
Rb content in liver0.80.92.21.11.31.51.01.10.80.4-1.0-0.0-0.9-0.70.7
Se content in liver0.91.02.5-1.0-0.9-0.9-0.7-1.3-1.6-0.50.9-0.91.11.1-1.0
Sr content in liver0.50.42.3-0.4-0.5-1.10.4-0.20.20.4-0.21.5-0.2-0.70.7
Zn content in liver0.20.20.8-0.0-0.4-0.30.4-0.2-0.30.60.5-0.90.40.5-0.2
Bone: minimum diameter0.50.93.11.11.31.80.80.60.40.1-0.7-1.6-0.20.2-0.5
Time in familiar zone, hab. session 10.70.81.6-0.6-0.40.1-1.1-0.9-0.7-1.10.7-1.00.91.2-1.3
Time in novel zone, hab. session 10.30.41.20.60.40.21.10.60.41.0-0.6-0.3-0.3-0.50.4
Total zone transitions, hab. session 10.30.40.70.70.70.5-0.20.70.80.3-0.70.4-0.6-0.70.8
Total locomotion distance, hab. session 10.20.31.2-0.7-0.6-0.4-1.1-0.4-0.3-0.80.40.50.10.2-0.1
Locomotion velocity, hab. session 10.10.20.6-0.4-0.4-0.4-0.8-0.2-0.1-0.60.30.8-0.0-0.10.2
Time in familiar zone, hab. session 20.50.51.3-0.4-0.10.4-1.1-0.5-0.3-1.00.4-0.80.61.0-1.2
Time in novel zone, hab. session 20.40.41.80.80.50.11.40.50.40.9-0.7-0.0-0.3-0.60.7
Total zone transitions, hab. session 20.10.10.40.50.30.20.20.40.60.6-0.3-0.6-0.1-0.1-0.1
Total locomotion distance, hab. session 20.50.61.1-0.8-0.8-0.8-0.7-0.8-0.6-0.80.7-0.31.00.9-1.1
Locomotion velocity, hab. session 20.40.51.0-0.7-0.8-0.8-0.7-0.7-0.5-0.70.6-0.21.00.8-0.9
Novel to familiar place preference ratio0.81.02.00.90.90.51.11.21.01.1-0.90.6-1.1-1.31.4
Novelty place preference0.81.11.90.91.00.61.11.21.01.2-1.00.5-1.1-1.31.4
Time in novel zone, NPP test1.21.52.11.21.30.91.31.41.31.3-1.20.3-1.2-1.41.4
Total zone transitions, NPP test0.10.10.40.40.40.5-0.10.30.60.2-0.4-0.3-0.3-0.20.0
Total locomotion distance, NPP test0.00.00.20.0-0.10.0-0.2-0.00.2-0.3-0.2-0.20.20.2-0.4
Locomotion velocity, NPP test0.10.20.3-0.5-0.6-0.5-0.6-0.5-0.2-0.60.30.10.40.4-0.5
Intraocular pressure0.40.72.60.30.50.90.1-0.3-0.0-0.80.0-1.60.91.1-1.4
Delta distance traveled before/after self-admin0.80.92.2-1.3-1.2-1.2-0.8-0.9-1.1-0.21.5-0.20.50.7-0.5
Delta ambulatory time before/after self-admin0.40.72.2-0.8-0.8-0.7-0.7-0.8-0.9-0.01.5-0.90.80.9-0.8
Parametrial fat weight0.92.05.90.2-0.2-1.31.21.11.01.6-1.02.4-1.1-1.92.1
Pavlov. Cond. lever latency0.81.02.9-1.7-1.1-0.9-1.0-1.1-1.1-1.30.61.2-0.00.1-0.1
Pavlov. Cond. magazine entry latency0.40.51.41.00.60.10.90.70.71.2-0.6-0.2-0.1-0.40.6
Pavlov. Cond. change in total contacts0.20.20.90.70.40.40.40.30.20.40.0-0.90.30.3-0.0
Pavlov. Cond. index score0.40.51.51.20.80.60.70.80.71.0-0.4-0.90.1-0.00.1
Pavlov. Cond. latency score0.70.92.51.61.10.80.91.11.01.3-0.6-1.00.0-0.20.3
Pavlov. Cond. lever contacts1.11.43.31.81.41.31.21.31.31.3-0.9-1.1-0.4-0.40.5
Pavlov. Cond. magazine entry number0.10.10.6-0.6-0.30.1-0.4-0.3-0.3-0.80.20.1-0.00.2-0.3
Pavlov. Cond. intertrial magazine entries0.20.30.6-0.3-0.5-0.3-0.2-0.5-0.5-0.50.6-0.50.60.7-0.8
Pavlov. Cond. lever-magazine prob. diff.0.50.61.51.20.90.70.70.80.81.0-0.5-0.90.0-0.10.2
Pavlov. Cond. response bias0.20.30.70.80.50.40.80.50.50.8-0.2-0.70.1-0.00.1
Pavlov. Cond. lever latency1.52.13.5-1.7-1.7-1.5-1.8-1.6-1.5-1.51.90.31.21.2-0.9
Pavlov. Cond. magazine entry latency1.21.73.70.81.41.40.81.41.30.3-1.41.2-1.9-1.61.5
Pavlov. Cond. change in total contacts1.12.84.91.31.51.31.31.71.61.2-2.21.4-2.1-2.01.8
Pavlov. Cond. index score1.32.03.21.41.61.51.41.61.41.1-1.80.4-1.6-1.51.2
Pavlov. Cond. latency score1.21.93.01.41.61.51.41.61.41.1-1.70.4-1.6-1.41.1
Pavlov. Cond. lever contacts1.72.53.71.91.91.61.91.81.71.6-1.9-0.4-1.4-1.30.9
Pavlov. Cond. magazine entry number0.70.92.1-0.5-1.1-1.3-0.2-1.0-0.90.11.1-0.81.51.1-0.7
Pavlov. Cond. intertrial magazine entries1.32.96.0-1.9-2.3-2.5-1.7-1.9-1.8-0.91.90.21.71.3-1.3
Pavlov. Cond. lever-magazine prob. diff.1.42.13.61.41.61.41.31.71.51.2-1.90.5-1.7-1.61.2
Pavlov. Cond. response bias1.11.62.61.21.41.21.21.41.41.0-1.60.4-1.5-1.41.1
Time in closed arm before self-admin0.20.41.4-0.50.10.1-0.5-0.6-1.2-1.2-0.3-0.20.60.5-0.5
Time in closed arm after self-admin0.10.10.7-0.30.10.10.1-0.1-0.9-0.4-0.5-0.10.30.2-0.0
Time in open arm before self-admin0.20.20.50.10.1-0.00.10.40.70.7-0.30.6-0.7-0.70.5
Time in open arm after self-admin2.02.24.51.11.10.70.91.62.11.8-0.91.0-1.9-1.91.7
Bone: periosteal estimation1.12.77.82.02.32.81.61.00.90.2-1.4-2.80.00.5-1.1
Bone: periosteal perimeter1.42.75.52.22.12.12.31.81.61.6-1.7-1.4-0.8-0.60.3
Bone: post-yield work0.61.03.31.01.31.80.90.50.4-0.3-0.4-1.80.40.7-0.9
Progressive ratio test 1 active lever presses0.71.23.1-1.5-1.7-1.5-1.1-1.3-1.1-0.70.80.30.70.7-0.4
Progressive ratio test 1 breakpoint0.61.12.8-1.4-1.7-1.4-1.0-1.3-1.1-0.80.70.20.70.8-0.5
Progressive ratio test 1 inactive lever presses0.10.31.2-0.6-0.6-0.7-0.1-0.20.2-0.10.21.1-0.4-0.50.5
Progressive ratio test 2 active lever presses0.71.01.7-0.6-1.0-0.7-0.5-1.1-0.9-0.81.1-1.11.21.3-1.1
Progressive ratio test 2 breakpoint0.71.01.6-0.6-1.0-0.6-0.5-1.1-0.8-0.81.2-1.11.21.3-1.2
Progressive ratio test 2 inactive lever presses0.10.20.7-0.6-0.8-0.70.2-0.30.10.30.50.1-0.00.00.2
Incentive Sensitization - Responses0.20.42.30.70.30.60.4-0.00.1-0.00.2-1.50.60.8-0.9
Incentive Sensitization - Breakpoint0.20.42.00.80.30.60.50.00.20.00.2-1.40.60.7-0.8
Sum of active levers in priming session hrs 5-62.01.93.0-1.3-1.4-1.0-1.5-1.7-1.0-1.41.6-0.51.41.5-1.6
Progressive ratio0.10.20.80.30.50.40.20.50.9-0.1-0.50.2-0.3-0.40.3
Food seeking constrained by brief footshock0.00.10.2-0.3-0.4-0.40.1-0.2-0.2-0.10.00.30.00.0-0.3
Seeking ratio, punishment vs. effort0.10.30.8-0.6-0.9-0.8-0.2-0.5-0.90.10.30.40.00.1-0.2
Retroperitoneal fat weight0.31.13.30.40.4-0.21.01.10.70.8-0.81.8-1.2-1.51.6
Reaction time number correct2.910.217.54.23.83.74.03.53.33.6-3.4-2.3-2.0-1.81.1
Reaction time mean minus median0.10.52.2-0.6-0.6-1.2-1.1-0.1-0.3-0.10.51.5-0.1-0.50.4
Reaction time mean minus median AUC0.00.20.6-0.1-0.3-0.7-0.70.1-0.10.40.10.8-0.1-0.40.4
Reaction time num false alarms0.50.81.50.80.90.30.81.01.20.8-0.90.8-0.7-1.11.2
Reaction time num false alarms AUC0.41.01.71.01.10.51.11.11.31.0-1.00.6-0.7-1.11.2
Reaction time trials correct on left2.910.217.54.23.83.74.03.53.33.6-3.4-2.3-2.0-1.81.1
Reaction time trials on left2.99.716.64.13.73.53.93.43.33.5-3.3-2.2-2.0-1.81.1
Reaction time mean1.73.88.1-2.3-2.2-2.6-2.8-1.7-1.8-1.91.72.31.20.6-0.8
Reaction time mean AUC1.33.06.8-2.0-1.9-2.2-2.6-1.5-1.6-1.91.52.01.10.6-0.7
Median of all reaction times3.14.98.8-2.6-2.6-2.8-3.0-2.2-2.3-2.32.01.81.71.2-1.3
Reaction time omissions1.62.77.1-1.8-1.9-2.7-1.8-1.5-1.7-1.31.61.31.60.7-0.7
Reaction time false alarm rate0.91.23.6-1.5-1.2-1.6-1.2-0.9-0.7-1.00.91.90.3-0.10.6
Reaction time premature initiation rate2.64.08.01.31.61.31.02.12.11.2-1.72.3-2.8-2.82.8
Reaction time premature initiations3.29.612.93.23.32.92.93.63.52.9-3.10.8-3.6-3.43.0
Std. dev. reaction times0.51.74.2-1.4-1.4-2.0-2.0-0.9-1.1-0.91.12.00.6-0.0-0.0
Reaction time trials completed2.99.716.64.13.73.53.93.43.33.5-3.3-2.2-2.0-1.81.1
Reaction time trials AUC2.910.017.24.13.73.54.03.43.43.6-3.3-2.3-1.9-1.71.0
Run reversals in cocaine runway, females0.30.30.7-0.8-0.7-0.7-0.4-0.5-0.6-0.20.80.6-0.1-0.1-0.1
Run reversals in cocaine runway, males0.10.20.4-0.3-0.3-0.3-0.2-0.5-0.2-0.50.1-0.20.60.6-0.5
Latency to leave start box in cocaine runway0.10.20.40.30.60.6-0.20.20.2-0.7-0.60.4-0.3-0.30.2
Latency to leave start box in cocaine runway, F0.20.30.80.70.80.90.30.30.3-0.8-0.8-0.20.20.1-0.1
Latency to leave start box in cocaine runway, M0.50.42.0-0.6-0.5-0.6-0.5-0.0-0.00.10.11.4-0.8-0.90.7
Std. dev. time between licks in bursts0.91.83.91.82.01.91.31.51.20.7-1.7-0.1-0.9-0.80.7
Total sessions with >9 infusions0.91.12.7-1.3-1.7-1.4-0.7-1.2-0.9-0.71.00.21.01.0-0.4
Short access day 1 total inactive lever presses0.61.12.0-1.2-1.4-1.3-0.7-1.3-0.8-0.71.40.30.90.9-1.0
Short access day 10 total inactive lever presses0.00.20.60.50.70.50.10.30.8-0.2-0.20.2-0.3-0.3-0.2
Short access day 1 total infusions0.51.02.1-1.2-1.4-1.5-1.0-1.0-0.6-1.01.11.20.60.4-0.1
Short access day 10 total infusions0.61.01.4-1.1-1.1-0.8-0.6-1.1-0.8-0.90.9-0.61.11.2-1.1
Short access total infusions1.01.43.5-1.7-1.9-1.6-1.0-1.3-1.0-0.71.40.50.70.8-0.6
Short access day 1 locomotion0.81.43.9-1.5-1.3-1.6-1.2-0.9-0.8-1.60.72.00.40.10.3
Short access day 10 total locomotion0.10.61.6-0.8-0.6-0.6-1.1-0.9-0.8-1.3-0.20.60.70.5-0.2
Short access total locomotion0.91.42.6-1.5-1.6-1.5-1.3-1.5-1.2-1.30.60.90.90.8-0.3
One hour access (0.3 mA shock)0.20.20.60.80.50.40.10.50.70.30.1-0.60.1-0.10.1
Compulsive drug intake1.11.74.41.92.11.71.11.61.20.9-1.0-0.5-0.8-0.90.8
One hour access (shock baseline)0.30.91.7-0.8-1.3-1.1-0.8-1.1-0.7-0.31.1-0.71.01.0-1.0
Social response proportion0.30.42.10.40.30.60.2-0.20.2-0.10.2-1.50.50.7-0.8
Social responses0.71.02.6-0.1-0.00.6-0.6-0.8-0.7-1.30.8-1.61.01.4-1.4
Social time0.91.42.9-1.1-0.8-0.4-1.7-1.2-1.2-1.51.6-0.51.01.1-1.4
Soleus weight6.017.630.45.55.14.65.14.54.54.3-4.7-2.2-2.8-2.72.2
Bone: stiffness0.50.82.71.21.11.31.10.30.2-0.0-0.4-1.60.60.6-0.8
Tibialis anterior weight1.24.28.62.92.52.22.91.71.72.3-2.0-2.7-0.4-0.50.2
Time to tail flick, vehicle, before self-admin0.10.10.30.40.10.30.60.00.30.2-0.3-0.6-0.00.1-0.1
Time to tail flick, vehicle, after self-admin0.20.51.7-0.3-0.6-0.30.2-0.8-0.30.10.1-1.00.91.0-1.3
Time to tail flick, test, before self-admin0.91.01.60.91.10.71.11.11.30.4-0.71.1-1.0-1.21.1
Time to tail flick, test, after self-admin0.30.30.80.70.70.50.50.50.9-0.1-0.70.6-0.4-0.60.6
Delta time to tail flick, vehicle, before/after SA0.20.20.5-0.6-0.7-0.5-0.3-0.5-0.20.20.2-0.20.30.4-0.6
Delta time to tail flick, test, before/after SA0.00.00.10.20.10.1-0.3-0.00.0-0.2-0.10.10.0-0.10.1
Tibia length1.23.47.62.82.52.62.31.81.51.2-1.8-2.2-0.1-0.1-0.1
Ambulatory time before self-admin0.41.22.60.80.90.91.01.21.11.1-1.60.3-1.2-1.21.3
Ambulatory time after self-admin0.10.10.4-0.4-0.2-0.2-0.00.20.10.6-0.40.0-0.4-0.30.6
Bone: tissue strength1.11.12.50.61.01.20.31.00.80.0-1.01.1-1.6-1.31.5
Total heroin consumption0.30.30.70.20.60.40.50.70.80.1-0.30.7-0.7-0.80.6
Bone: trabecular number1.52.85.62.42.12.02.31.61.71.4-1.8-1.5-0.6-0.60.5
Bone: trabecular spacing0.60.83.4-0.1-0.2-0.70.10.60.50.9-0.31.9-1.0-1.31.3
Bone: trabecular thickness1.31.84.3-0.4-0.7-0.5-0.2-1.3-1.3-0.80.9-2.02.12.0-2.0
Bone: trabecular tissue density0.30.51.0-0.8-0.6-0.4-0.9-0.8-0.7-0.70.5-0.30.60.6-1.0
Water consumed over 24 hours2.44.78.02.82.52.42.62.42.72.5-2.1-1.4-1.5-1.30.9
Number of responses in last shaping day0.81.04.8-0.9-1.0-1.2-1.2-0.20.1-0.80.72.2-0.3-0.60.7