Cpne3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	Cpne3	0.09	0.04	1.1e-16	0.1	0.12	0.13	0.13	3.4e-15	1.4e-17	2.0e-19	3.1e-19
2	PL	gene expression	Cpne3	0.04	0.03	5.2e-04	0.01	0.02	0.01	0.01	2.1e-02	3.9e-03	1.3e-02	6.0e-02
3	Brain	gene expression	Cpne3	0.19	0.08	0.0e+00	0.16	0.17	0.17	0.16	6.3e-15	8.6e-16	2.8e-15	1.1e-14
4	Brain	mRNA stability	Cpne3	0.1	0.05	2.7e-10	0.07	0.1	0.12	0.1	3.0e-07	4.0e-09	1.7e-11	7.2e-10
5	BLA	mRNA stability	Cpne3	0.25	0.11	7.9e-11	0.16	0.16	0.16	0.16	7.3e-09	1.1e-08	1.4e-08	7.4e-09
6	PL	mRNA stability	Cpne3	0.09	0.04	2.2e-11	0.12	0.11	0.11	0.11	5.4e-13	6.0e-12	1.1e-11	1.3e-11
7	Adipose	mRNA stability	Cpne3	0.03	0.02	8.8e-03	0.01	0.01	0.01	0.01	4.0e-02	4.0e-02	5.5e-02	4.3e-02
8	Liver	gene expression	Cpne3	0.08	0.04	7.5e-08	0.06	0.06	0.05	0.05	7.7e-07	9.1e-07	1.7e-06	2.0e-06
9	NAcc	gene expression	Cpne3	0.03	0.02	4.3e-04	0.03	0.02	0.02	0.03	7.1e-05	3.6e-04	1.2e-04	7.5e-05
10	Adipose	gene expression	Cpne3	0.16	0.08	8.1e-11	0.06	0.07	0.06	0.06	1.0e-07	1.1e-08	5.5e-07	2.1e-07
11	Brain	intron excision ratio	chr5_37829062_37833645	0.03	0.02	7.6e-03	0.02	0.03	0.02	0.02	2.8e-03	1.2e-03	4.8e-03	3.7e-03
12	pVTA	gene expression	Cpne3	0.08	0.04	4.9e-06	0.03	0.07	0.07	0.06	1.1e-03	3.0e-06	2.2e-06	1.5e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	0.8	1.4	5.2	-1.7	1.3	1.4	-1.5	-0.5	-0.6	-0.4	0.7	2.3	0.8	0.7	0.7
Area under the delay curve	1.1	1.3	3.2	1.8	-1.2	-1.1	1.1	1.2	1.5	1.6	-0.5	-0.9	0.7	0.6	0.2
BMI with tail	0.6	2.2	9.3	-1.8	1.6	1.6	-1.7	-0.4	-0.1	-1.0	0.9	3.0	0.8	1.0	1.4
BMI without tail	0.5	1.4	5.9	-0.6	1.0	1.6	-0.4	0.4	0.9	0.7	0.2	2.4	0.9	1.3	1.6
Body weight	1.6	7.2	12.5	-3.5	3.2	3.4	-3.3	-2.7	-2.3	-3.2	2.8	2.6	-1.6	-1.1	-0.7
Weight adjusted by age	0.4	0.6	1.8	0.0	0.1	0.2	0.1	0.7	0.5	0.7	-0.5	1.4	1.2	1.2	0.9
Bone surface	1.2	2.2	5.9	-2.4	2.2	1.9	-2.0	-1.2	-1.1	-0.7	1.5	1.8	0.2	0.1	0.2
Bone volume	0.9	1.6	4.0	-2.0	1.7	1.6	-1.7	-0.9	-0.8	-0.7	1.2	1.7	0.3	0.1	0.3
Breakpoint value in progressive ratio session	0.4	0.5	1.8	0.8	-0.3	-0.4	0.8	0.6	0.2	1.4	-1.0	-0.4	0.5	0.3	0.7
Number of licking bursts	0.3	0.5	2.2	0.5	-0.5	-0.7	0.6	-0.0	-0.3	-0.2	0.1	-1.5	-0.7	-0.8	-0.9
Context. condit. distance diff. score	1.4	1.7	3.9	2.0	-1.5	-0.9	1.8	1.6	1.3	1.3	-1.5	0.1	0.5	0.9	1.0
Locomotion velocity, session 1	2.1	2.3	4.4	-2.1	1.6	1.4	-1.9	-1.5	-1.7	-1.9	1.6	1.4	-0.5	-0.6	-0.5
Locomotion distance, session 1	1.5	1.9	3.1	-1.3	1.2	1.0	-1.1	-1.5	-1.8	-1.5	1.6	-0.3	-1.6	-1.5	-1.2
Locomotion velocity, session 2	0.2	0.2	0.7	0.3	-0.6	-0.8	0.6	0.3	0.3	-0.0	-0.4	-0.5	0.1	-0.1	-0.0
Locomotion distance, session 2	0.1	0.1	0.5	0.1	-0.0	-0.0	0.7	-0.1	-0.3	0.3	0.3	-0.7	-0.3	-0.4	-0.2
Locomotion velocity, session 3	0.6	0.7	1.8	-1.1	1.3	1.4	-0.8	-0.5	-0.7	-0.4	0.5	1.2	-0.2	-0.0	0.2
Locomotion distance, session 3	0.7	0.8	2.7	0.2	0.3	0.9	0.4	0.8	0.7	1.1	-0.8	1.6	0.6	1.1	1.2
Stereotopy head waving bouts, day 3	0.7	0.8	4.6	0.0	0.4	0.2	1.0	-0.5	-0.5	1.0	0.9	-2.1	-0.7	-0.9	-0.8
Stereotopy head waving duration, day 3	0.2	0.3	1.5	0.1	-0.1	-0.1	0.6	-0.3	-0.3	0.3	0.8	-1.2	-0.4	-0.5	-0.4
Locomotion velocity, session 7	0.7	0.7	1.4	1.2	-1.2	-0.9	0.9	1.2	1.1	0.2	-0.6	0.5	0.5	0.7	0.7
Locomotion distance, session 7	0.4	0.5	1.0	0.7	-0.7	-0.2	0.8	0.9	0.8	0.2	-0.6	1.0	0.4	0.8	0.7
Stereotopy head waving bouts, day 7	0.3	0.3	1.0	0.8	-0.2	-0.1	1.0	0.3	0.3	0.9	0.0	-1.0	-0.4	-0.3	-0.1
Stereotopy head waving duration, day 7	0.2	0.3	0.7	-0.2	0.5	0.3	-0.1	-0.4	-0.3	-0.2	0.9	-0.6	-0.6	-0.7	-0.5
Locomotion velocity, session 8	0.1	0.1	0.5	0.3	-0.3	-0.4	0.7	0.2	0.0	0.1	-0.1	-0.3	-0.1	-0.2	-0.0
Locomotion distance, session 8	0.2	0.3	1.7	0.9	-0.6	-0.3	1.3	0.4	0.1	0.6	-0.2	-0.5	-0.3	-0.0	0.1
Degree of sensitization distance	0.4	0.4	1.6	0.4	-0.9	-1.3	0.5	0.1	0.1	-0.7	0.1	-1.1	-0.1	-0.5	-0.7
Degree of sensitization stereotypy	0.6	0.6	1.6	1.3	-0.7	-0.4	1.1	0.9	0.9	1.0	-0.7	-0.1	0.2	0.5	0.5
Conditioned locomotion	0.3	0.4	0.9	-0.6	0.1	-0.8	-0.8	-0.4	-0.3	-1.0	0.6	-0.5	0.1	-0.6	-0.7
Cocaine response after cond. corrected	0.4	0.5	2.5	0.8	-0.6	-0.9	0.8	0.3	0.4	0.5	-0.2	-1.6	-0.4	-0.7	-0.5
Cocaine response after cond. not corrected	0.4	0.5	2.2	0.6	-0.4	-0.6	0.7	0.1	0.2	0.2	0.0	-1.5	-0.7	-0.9	-0.8
Cocaine response before conditioning	0.1	0.1	0.7	-0.4	0.4	0.8	0.0	-0.1	-0.1	0.0	0.0	0.6	-0.3	0.1	-0.1
Saline control response	4.5	6.0	11.9	-3.2	2.9	2.5	-3.5	-2.5	-2.5	-2.7	2.6	1.3	-1.4	-1.5	-1.4
Bone: connectivity density	0.6	0.9	2.4	-1.6	1.1	0.7	-1.4	-0.5	-0.6	-0.5	0.6	1.5	0.8	0.4	0.3
Bone: cortical apparent density	0.6	0.8	1.9	0.3	-0.6	-0.5	0.3	0.8	0.8	0.3	-0.7	1.2	1.4	1.3	1.4
Bone: cortical area	0.1	0.2	0.5	-0.6	0.5	0.2	-0.4	-0.1	0.0	0.1	0.2	0.7	0.7	0.5	0.7
Bone: cortical porosity	1.4	1.6	3.5	-0.7	0.4	-0.1	-0.3	-1.2	-1.2	-1.4	0.8	-1.7	-1.6	-1.9	-1.8
Bone: cortical porosity	0.9	1.0	2.3	-0.6	0.4	0.1	-0.1	-1.1	-1.1	-1.0	0.5	-1.3	-1.3	-1.5	-1.4
Bone: cortical thickness	0.8	1.3	2.8	1.1	-1.4	-1.7	1.1	1.2	1.2	0.8	-1.2	-0.4	1.3	0.8	0.8
Bone: cortical thickness	0.4	0.4	1.2	0.2	-0.7	-0.8	-0.0	0.5	0.5	-0.2	-0.3	0.7	1.1	0.8	1.0
Bone: cortical tissue density	0.5	0.7	1.8	0.3	-0.6	-0.4	0.2	0.8	0.7	0.2	-0.7	1.2	1.3	1.2	1.3
Condit. Reinf. active minus inactive responses	1.1	1.2	3.1	1.4	-1.2	-1.0	1.8	0.9	0.9	1.0	-1.7	-0.4	0.5	0.7	0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.3	0.1	0.2	0.5	-0.2	-0.3	0.1	-0.3	-0.7	-0.7	-0.5	-0.4
Condit. Reinf. active responses	2.1	2.6	5.5	1.9	-1.9	-1.7	2.3	1.4	1.5	1.5	-2.3	-0.5	1.2	1.1	1.1
Condit. Reinf. inactive responses	2.5	3.0	5.0	1.8	-2.1	-2.0	2.2	1.7	1.8	1.7	-2.0	-0.4	1.7	1.5	1.4
Incentive salience index mean	0.8	0.9	2.8	1.1	-1.1	-1.1	1.7	0.7	0.7	0.9	-1.4	-0.9	0.5	0.4	0.3
Condit. Reinf. lever presses	0.2	0.3	1.1	0.3	-0.7	-1.0	0.7	0.5	0.5	0.2	-0.6	-0.3	0.7	0.3	0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	0.1	-0.0	-0.1	-0.5	-0.1	-0.2	-0.0	0.4	-0.7	-0.1	-0.2	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.5	-0.2	0.2	-0.0	-0.7	-0.3	-0.4	-0.3	0.3	-0.7	-0.2	-0.3	-0.5
Condit. Reinf. active responses	0.0	0.0	0.2	0.0	-0.1	-0.1	-0.3	0.1	-0.0	-0.1	0.4	-0.1	0.1	0.1	0.2
Condit. Reinf. inactive responses	0.1	0.1	0.5	-0.3	0.3	0.5	-0.1	-0.2	-0.2	-0.4	0.5	0.7	-0.2	0.0	0.3
Condit. Reinf. lever presses	0.6	0.8	2.8	-1.1	0.6	0.3	-1.5	-0.8	-0.8	-1.7	1.1	0.8	-0.3	-0.3	-0.1
Condit. Reinf. lever reinforcers received	0.0	0.0	0.2	0.1	-0.1	-0.1	-0.2	-0.0	-0.1	-0.2	0.5	-0.4	-0.1	-0.1	-0.0
Conditioned reinforcement - actives	0.1	0.2	0.8	0.4	-0.7	-0.5	0.5	0.5	0.4	0.2	-0.9	0.3	0.4	0.5	0.3
Conditioned reinforcement - inactives	0.4	0.5	1.2	0.7	-1.1	-0.8	0.4	1.1	0.6	0.5	-0.4	0.4	0.8	0.9	0.8
Conditioned locomotion	1.9	2.5	4.1	1.2	-1.5	-1.2	1.8	1.9	1.6	1.8	-2.0	0.5	1.7	1.7	1.4
Patch foraging indifference point 0 sec	2.1	3.9	8.4	-2.8	2.5	2.3	-2.9	-2.0	-1.9	-2.0	1.6	1.9	-0.6	-0.5	-0.5
Patch foraging indifference point AUC	0.9	1.3	2.3	-1.0	1.2	1.0	-0.7	-1.3	-1.1	-0.7	1.5	-0.7	-1.3	-1.3	-1.2
Delay disc. indifference point, 0s delay	0.2	0.2	0.7	0.0	0.5	0.6	-0.8	-0.2	-0.1	0.0	0.6	0.0	-0.5	-0.3	-0.4
Delay disc. indifference point, 16s delay	0.7	0.7	1.8	1.3	-1.1	-1.1	0.6	0.7	1.2	0.8	-0.9	-0.9	0.3	0.2	-0.3
Delay disc. indifference point, 2s delay	0.7	0.8	1.9	1.3	-0.8	-0.9	0.9	0.8	0.9	1.4	-0.7	-1.3	0.3	0.1	-0.3
Delay disc. indifference point, 24s delay	2.4	2.6	4.5	2.1	-1.9	-1.9	1.7	1.7	2.1	1.6	-1.4	-0.4	1.4	1.3	1.3
Delay disc. indifference point, 4s delay	0.3	0.3	1.0	0.8	-0.3	0.0	-0.1	0.5	1.0	0.5	0.2	0.6	0.4	0.6	0.5
Delay disc. indifference point, 8s delay	1.2	1.5	3.1	1.7	-1.3	-1.2	1.0	1.4	1.8	1.5	-0.4	-0.2	1.0	1.0	0.8
Indifference point function ln k	0.1	0.1	0.3	-0.4	0.5	0.5	-0.6	-0.4	-0.3	-0.1	0.1	0.2	-0.0	-0.1	-0.1
Indifference point function log k	0.1	0.1	0.3	-0.4	0.5	0.5	-0.6	-0.4	-0.3	-0.1	0.1	0.2	-0.0	-0.1	-0.1
Patch foraging total patch changes 0 sec	2.5	4.8	10.4	-3.1	2.7	2.6	-3.2	-2.2	-2.1	-2.3	1.8	2.2	-0.8	-0.6	-0.5
Patch foraging total patch changes 12 sec	2.5	3.3	7.8	-2.8	2.2	1.9	-2.3	-1.8	-1.5	-2.0	1.8	2.1	-0.2	-0.3	-0.2
Patch foraging total patch changes 18 sec	2.6	3.9	7.3	-2.2	2.2	2.2	-2.7	-2.3	-2.0	-2.2	2.1	0.8	-1.7	-1.4	-1.1
Patch foraging total patch changes 24 sec	0.9	1.5	3.1	-1.2	1.2	1.5	-1.8	-1.4	-1.3	-1.2	0.9	0.4	-1.3	-0.9	-1.0
Patch foraging total patch changes 6 sec	2.8	4.3	7.4	-2.7	2.6	2.3	-2.4	-2.4	-2.4	-1.9	2.1	0.4	-1.5	-1.4	-1.5
Patch foraging time to switch 0 sec	1.7	3.5	4.9	1.8	-2.1	-2.1	1.9	2.2	2.0	1.8	-2.0	0.1	2.1	1.7	1.5
Patch foraging water rate 0 sec	1.6	3.4	7.9	-2.2	1.9	1.6	-2.6	-2.1	-1.8	-2.8	1.6	1.1	-1.3	-1.2	-0.9
Patch foraging water rate 12 sec	0.7	1.4	4.6	-0.9	0.8	1.2	-1.7	-1.2	-1.0	-2.1	0.5	0.9	-1.4	-0.9	-0.5
Patch foraging water rate 18 sec	0.2	0.3	1.4	-0.6	0.3	0.4	-1.0	-0.5	-0.3	-1.2	0.1	0.6	-0.5	-0.3	-0.3
Patch foraging water rate 24 sec	1.7	2.4	3.7	-1.6	1.7	1.8	-1.7	-1.8	-1.7	-1.7	1.1	0.1	-1.9	-1.6	-1.3
Patch foraging water rate 6 sec	1.8	2.6	4.7	-1.6	1.3	1.4	-2.0	-1.8	-1.8	-2.2	1.4	0.2	-1.8	-1.5	-1.3
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.3	-0.5	0.9	0.6	-0.4	-0.9	-1.0	-0.0	0.9	-1.1	-1.0	-1.2	-1.1
Distance traveled before self-admin	1.0	1.3	3.7	-1.0	1.1	1.1	-1.2	-1.3	-1.0	-1.1	1.9	0.1	-1.0	-0.9	-1.1
Distance traveled after self-admin	0.3	0.4	1.5	0.1	0.1	0.1	-0.4	-0.6	-0.5	-1.2	0.6	0.2	-0.9	-0.7	-0.8
Extensor digitorum longus weight	0.5	1.8	2.9	-1.7	1.7	1.5	-1.7	-1.4	-1.3	-1.6	1.2	1.0	-1.0	-0.8	-0.7
Bone: elastic displacement	0.4	0.5	1.8	0.8	-0.7	-0.8	1.1	0.2	0.0	0.1	-0.2	-1.4	-0.5	-0.6	-0.5
Bone: elastic work	0.3	0.4	1.0	-0.1	0.2	0.2	0.3	-0.6	-0.6	-0.5	0.6	-0.9	-1.0	-0.9	-0.7
Bone: endosteal estimation	1.9	4.2	14.1	-2.4	3.0	3.7	-2.0	-1.5	-1.4	-0.5	1.9	3.0	-0.8	0.1	0.7
Bone: endosteal perimeter	1.6	3.4	7.4	-2.2	2.6	2.7	-2.2	-1.9	-1.7	-1.2	2.1	1.3	-1.3	-0.9	-0.4
Epididymis fat weight	0.1	0.5	1.1	-0.9	0.7	0.4	-0.9	-0.8	-0.8	-1.0	0.4	0.4	-0.3	-0.4	-0.3
Delta time in closed arm before/after self-admin	0.2	0.2	0.8	0.2	-0.3	-0.3	0.0	-0.2	-0.0	-0.2	0.2	-0.9	-0.5	-0.5	-0.7
Delta time in open arm before/after self-admin	1.0	1.0	1.7	-1.2	1.1	0.9	-1.2	-1.1	-1.2	-1.3	0.8	0.2	-0.9	-0.9	-0.9
Diff in mean of infusions in LGA sessions	0.2	0.3	0.8	0.1	0.1	0.2	0.4	0.5	0.3	0.8	-0.5	0.9	0.7	0.7	0.6
Delay discount exponential model param	1.2	1.4	3.1	-1.8	1.2	1.1	-1.1	-1.2	-1.6	-1.7	0.5	0.7	-0.9	-0.7	-0.4
Extinction: sum of active levers before priming	0.3	0.4	1.1	-1.0	0.8	0.8	-0.5	-0.4	-0.8	-0.3	-0.2	0.9	0.0	0.0	0.3
Active lever presses in extinction session 6	1.0	1.0	1.9	1.0	-1.0	-0.6	0.5	1.1	1.0	0.4	-0.7	1.1	1.1	1.3	1.4
Bone: final force	0.5	0.7	2.5	-1.2	1.3	1.6	-0.8	-0.6	-0.4	-0.1	0.7	1.1	-0.1	0.2	0.4
Bone: final moment	0.5	0.8	3.0	-1.2	1.4	1.7	-0.7	-0.6	-0.4	0.0	0.7	1.3	-0.0	0.3	0.6
Food consumed during 24 hour testing period	1.4	1.9	4.4	-1.7	1.9	2.1	-1.2	-1.4	-1.3	-1.0	1.3	1.3	-1.1	-0.7	-0.3
Glucose	0.3	0.5	1.0	0.8	-0.9	-0.8	0.7	0.8	0.8	0.3	-1.0	0.2	0.7	0.7	0.6
Heart weight	0.1	0.2	0.8	0.0	0.1	0.2	-0.6	-0.2	0.4	-0.9	0.3	0.3	-0.5	-0.3	-0.2
Delay discount hyperbolic model param	1.0	1.1	2.6	-1.6	1.0	1.0	-0.9	-1.1	-1.5	-1.5	0.4	0.7	-0.7	-0.6	-0.3
Intermittent access intake day 1-15 change	0.2	0.4	0.9	-1.0	0.7	0.6	-0.4	-0.7	-0.9	-0.3	0.8	-0.3	-0.5	-0.6	-0.8
Intermittent access intake escalation	0.2	0.4	1.2	-1.1	0.7	0.7	-0.5	-0.7	-0.7	-0.2	0.8	0.1	-0.4	-0.5	-0.6
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.5	0.3	0.2	-0.0	-0.4	-0.4	-0.0	0.3	-0.5	-0.4	-0.5	-0.4
Intermitt. access day 1 inactive lever presses	0.1	0.5	2.6	0.6	-0.1	-0.2	0.4	0.8	0.8	1.6	-0.3	-0.3	0.8	0.6	0.7
Intermitt. access day 15 inactive lever presses	0.6	1.3	2.3	1.5	-1.3	-1.3	1.2	1.2	1.1	1.3	-1.4	-0.6	0.8	0.8	0.7
Intermitt. access escalation Index	0.1	0.2	0.5	-0.2	0.3	0.1	0.1	-0.5	-0.4	-0.1	-0.1	-0.7	-0.6	-0.7	-0.7
Intermittent access day 1 total infusions	0.3	0.5	1.2	0.9	-1.1	-0.8	0.1	0.8	0.5	-0.2	-0.6	0.9	0.6	0.8	0.7
Intermittent access day 15 total infusions	0.2	0.3	0.8	0.4	-0.9	-0.6	0.3	0.7	0.5	0.3	-0.3	0.5	0.6	0.6	0.4
Intermittent access terminal intake (last 3 days)	0.6	0.8	1.4	0.8	-1.1	-0.8	0.5	1.2	1.0	0.5	-0.6	0.8	1.0	1.1	0.9
Intermittent access total infusions	0.3	0.3	0.9	0.4	-0.8	-0.5	0.1	0.5	0.3	-0.2	-0.6	1.0	0.6	0.7	0.6
Intermittent access day 1 locomotion	1.2	1.5	2.8	1.7	-1.6	-1.5	1.3	1.5	1.3	1.1	-1.2	-0.4	0.9	0.9	0.5
Intermittent access day 15 total locomotion	0.6	1.1	2.2	1.5	-1.4	-1.4	1.2	1.0	0.6	1.2	-0.5	-1.5	0.4	0.2	-0.4
Intermittent access total locomotion	0.9	1.1	2.2	1.5	-1.5	-1.4	1.3	1.2	0.9	1.0	-0.7	-0.8	0.6	0.5	0.0
Intermittent access standard deviation	0.3	0.6	1.6	0.2	-0.6	-0.3	-0.1	0.9	0.7	0.1	-0.1	1.3	0.9	1.2	1.1
Left kidney weight	0.8	3.6	7.3	-2.1	2.4	2.7	-1.6	-2.1	-1.9	-1.8	2.0	0.6	-2.0	-1.5	-1.1
Right kidney weight	0.8	3.5	6.2	-2.0	2.3	2.5	-1.7	-2.2	-1.8	-1.7	2.0	0.0	-2.0	-1.6	-1.3
Cocaine induced anxiety	1.1	1.6	3.9	0.4	-0.9	-0.4	0.1	1.3	1.1	0.2	-1.5	2.0	1.5	1.8	1.9
Post-drug Anxiety	0.8	0.9	2.2	0.5	-0.7	-0.3	0.2	1.1	0.9	0.2	-1.2	1.5	1.0	1.3	1.2
Baseline Anxiety	1.0	1.1	3.3	-0.0	0.5	0.2	0.2	-0.8	-0.8	0.1	1.2	-1.8	-1.3	-1.5	-1.8
Tail length	0.2	0.9	2.0	-0.7	1.0	1.3	-0.6	-0.9	-0.8	-0.2	1.0	-0.4	-1.4	-1.1	-1.0
Length with tail	1.7	7.4	10.1	-3.1	2.9	2.9	-3.0	-3.2	-3.1	-3.0	2.8	0.6	-2.6	-2.2	-2.1
Length without tail	1.1	3.6	6.9	-2.4	1.9	1.8	-2.5	-2.1	-2.2	-2.6	1.8	0.9	-1.4	-1.1	-1.0
Times rat made contact with spout	2.0	2.3	3.8	-1.8	1.8	1.9	-1.5	-1.7	-1.8	-1.3	1.5	0.6	-1.5	-1.2	-1.0
Lifetime Intake	0.4	0.5	1.2	0.7	-1.1	-0.8	0.2	0.7	0.4	-0.0	-0.8	0.6	0.6	0.7	0.6
Liver weight, left	0.4	0.7	2.0	-1.3	1.1	0.3	-1.4	-1.0	-0.6	-1.0	0.6	0.1	0.2	-0.4	-0.4
Liver weight, right	0.5	0.8	1.7	-1.3	1.1	1.0	-1.2	-1.0	-0.9	-1.0	0.8	0.8	-0.4	-0.3	-0.2
Locomotor activity	0.5	0.7	3.0	-1.1	1.5	1.7	-0.5	-0.6	-0.5	0.8	0.5	0.4	-0.4	-0.2	-0.5
Locomotor testing distance	1.4	2.4	6.6	-1.8	2.2	2.6	-1.2	-1.6	-1.7	-0.2	1.4	0.1	-1.6	-1.1	-1.3
Locomotor testing rearing	2.3	4.7	8.4	-2.0	2.5	2.9	-1.6	-2.4	-2.4	-1.0	2.3	-0.9	-2.8	-2.2	-2.2
Locomotion in novel chamber	0.8	1.0	3.0	-1.7	1.6	1.4	-0.7	-1.0	-1.2	-0.5	0.8	0.5	-0.3	-0.4	-0.6
Locomotion in novel chamber post-restriction	0.4	0.7	1.1	-0.8	0.9	0.6	0.1	-1.0	-1.1	-0.5	0.8	-0.9	-0.9	-1.0	-0.8
Fecal boli incidents, locomotor time 1	3.0	4.4	6.4	-2.5	2.3	1.9	-2.2	-2.5	-2.5	-2.1	2.2	-0.2	-1.8	-1.9	-2.0
Change in fecal boli incidents, locomotor task	6.3	6.2	9.0	2.7	-2.7	-2.2	2.4	3.0	2.5	2.8	-2.6	0.4	2.5	2.5	2.5
Time >=10cm from walls, locomotor time 1	2.5	2.7	3.9	1.5	-1.7	-1.3	1.9	1.9	2.0	1.5	-1.8	0.6	1.5	1.6	1.9
Bouts of movement, locomotor time 1	0.7	0.8	1.9	-1.3	1.4	1.2	-1.1	-0.9	-0.8	-0.2	0.8	-0.1	-0.6	-0.7	-0.4
Total resting periods, locomotor time 1	1.1	1.2	2.9	-1.6	1.7	1.4	-1.4	-1.2	-1.2	-0.5	0.9	-0.0	-0.7	-0.8	-0.5
Rest time, locomotor task time 1	0.5	0.6	1.8	-1.1	0.8	0.9	-1.4	-0.6	-0.8	-0.8	0.3	1.2	-0.1	0.0	0.4
Distance moved, locomotor task time 1	0.4	0.6	2.4	0.7	-0.7	-0.9	1.5	0.5	0.6	0.8	-0.2	-1.2	-0.0	-0.2	-0.3
Vertical activity count, locomotor time 1	0.6	1.3	4.4	1.4	-1.1	-1.1	2.1	1.1	1.2	1.6	-0.4	-1.4	0.1	0.0	-0.0
Time >=10cm from walls, locomotor time 2	1.4	2.1	4.1	0.9	-1.4	-1.2	1.1	1.7	1.3	1.8	-1.4	0.5	2.0	1.8	1.6
Bouts of movement, locomotor time 2	0.6	1.0	2.6	0.8	-0.8	-0.5	0.7	1.1	1.6	0.8	-0.6	0.8	1.3	1.3	1.1
Total resting periods, locomotor time 2	0.3	0.6	1.7	0.4	-0.4	-0.1	0.3	0.7	1.3	0.5	-0.3	1.1	1.0	1.1	0.9
Rest time, locomotor task time 2	0.4	0.5	1.6	-0.9	1.1	1.3	-0.4	-0.8	-0.5	-0.5	0.4	0.7	-0.5	-0.3	0.1
Distance moved, locomotor task time 2	0.4	0.5	2.1	0.5	-0.6	-0.9	0.7	0.5	0.2	0.8	0.3	-1.5	-0.1	-0.5	-0.5
Vertical activity count, locomotor time 2	1.1	1.5	3.7	1.4	-1.2	-1.4	1.7	1.5	1.2	1.9	-0.3	-1.5	0.6	0.3	0.1
Light reinforcement 1	0.1	0.1	0.6	-0.2	0.0	0.2	-0.7	-0.3	-0.3	-0.6	-0.2	0.6	0.0	0.2	-0.0
Light reinforcement 2	0.8	1.2	2.6	1.6	-1.4	-1.4	0.9	1.1	1.3	0.9	-1.3	-0.7	0.6	0.6	0.2
Bone: marrow area	1.9	4.2	14.0	-2.4	3.0	3.7	-1.9	-1.4	-1.3	-0.4	1.9	3.0	-0.7	0.1	0.8
Bone: maximum diameter	0.3	0.6	1.4	-1.0	1.1	1.1	-1.0	-0.5	-0.3	0.2	0.7	1.2	0.4	0.4	0.6
Bone: maximum force	0.4	0.8	2.6	-0.9	1.2	1.6	-0.5	-0.3	-0.1	0.4	0.3	1.6	0.3	0.6	1.0
Bone: maximum moment	0.6	1.0	3.5	-1.0	1.3	1.8	-0.4	-0.2	-0.0	0.5	0.3	1.9	0.4	0.8	1.2
Mean time between licks in bursts	0.0	0.1	0.5	0.3	0.2	0.4	0.6	-0.0	0.2	0.7	0.1	-0.5	-0.2	0.0	0.1
Mean num. licks in bursts	0.8	1.2	4.3	-1.4	1.3	1.6	-1.4	-0.7	-0.6	-0.6	0.5	2.1	0.0	0.3	0.5
Cd content in liver	0.3	0.3	0.8	-0.9	0.9	0.7	-0.7	-0.6	-0.4	-0.4	0.5	0.8	-0.1	-0.1	-0.0
Co content in liver	4.5	5.2	12.9	-2.8	3.1	3.6	-2.7	-2.1	-2.1	-1.5	2.2	2.1	-1.7	-0.9	-0.7
Cu content in liver	0.4	0.5	2.1	-0.3	-0.2	-0.6	-1.0	-0.4	-0.0	-1.4	0.4	-0.4	-0.5	-0.6	-1.1
Fe content in liver	0.2	0.2	0.9	0.2	0.2	0.5	-0.1	-0.4	-0.1	-0.4	0.2	-0.1	-0.9	-0.6	-0.7
K content in liver	0.2	0.2	0.4	-0.0	-0.4	-0.6	-0.4	-0.0	0.0	-0.6	0.3	-0.6	0.0	-0.2	-0.5
Mg content in liver	0.2	0.2	1.0	-0.4	-0.1	-0.1	-0.7	-0.0	0.1	-0.8	0.0	1.0	0.5	0.4	0.1
Mn content in liver	0.4	0.5	1.3	0.1	-0.6	-1.1	-0.1	0.0	-0.1	-1.2	0.4	-1.0	-0.4	-0.7	-0.9
Na content in liver	1.1	1.2	3.1	-0.8	0.4	0.1	-1.8	-0.9	-1.0	-1.7	0.7	-0.3	-0.9	-1.1	-1.7
Rb content in liver	0.8	0.9	2.2	-1.1	1.3	1.5	-1.0	-1.1	-0.8	-0.4	1.0	0.0	-0.9	-0.7	-0.7
Se content in liver	0.9	1.0	2.5	1.0	-0.9	-0.9	0.7	1.3	1.6	0.5	-0.9	0.9	1.1	1.1	1.0
Sr content in liver	0.5	0.4	2.3	0.4	-0.5	-1.1	-0.4	0.2	-0.2	-0.4	0.2	-1.5	-0.2	-0.7	-0.7
Zn content in liver	0.2	0.2	0.8	0.0	-0.4	-0.3	-0.4	0.2	0.3	-0.6	-0.5	0.9	0.4	0.5	0.2
Bone: minimum diameter	0.5	0.9	3.1	-1.1	1.3	1.8	-0.8	-0.6	-0.4	-0.1	0.7	1.6	-0.2	0.2	0.5
Time in familiar zone, hab. session 1	0.8	0.8	1.6	0.6	-0.4	0.1	1.0	0.9	0.7	1.1	-0.7	1.0	0.9	1.2	1.3
Time in novel zone, hab. session 1	0.4	0.4	1.1	-0.6	0.4	0.2	-1.1	-0.6	-0.4	-1.0	0.6	0.3	-0.3	-0.5	-0.4
Total zone transitions, hab. session 1	0.3	0.4	0.7	-0.7	0.7	0.5	0.2	-0.7	-0.8	-0.3	0.7	-0.4	-0.6	-0.7	-0.8
Total locomotion distance, hab. session 1	0.2	0.3	1.2	0.7	-0.6	-0.4	1.1	0.4	0.3	0.8	-0.4	-0.5	0.1	0.2	0.1
Locomotion velocity, hab. session 1	0.1	0.2	0.6	0.4	-0.4	-0.4	0.8	0.2	0.1	0.6	-0.3	-0.8	-0.0	-0.1	-0.2
Time in familiar zone, hab. session 2	0.5	0.5	1.3	0.4	-0.1	0.4	1.1	0.5	0.3	1.0	-0.4	0.8	0.6	1.0	1.2
Time in novel zone, hab. session 2	0.4	0.4	1.8	-0.8	0.5	0.1	-1.3	-0.5	-0.4	-0.9	0.7	0.0	-0.3	-0.6	-0.7
Total zone transitions, hab. session 2	0.1	0.1	0.4	-0.5	0.3	0.2	-0.2	-0.4	-0.6	-0.6	0.3	0.6	-0.1	-0.1	0.1
Total locomotion distance, hab. session 2	0.5	0.6	1.1	0.8	-0.8	-0.8	0.7	0.8	0.6	0.8	-0.7	0.3	1.0	0.9	1.1
Locomotion velocity, hab. session 2	0.4	0.5	1.0	0.7	-0.8	-0.8	0.6	0.7	0.5	0.7	-0.6	0.2	1.0	0.8	0.9
Novel to familiar place preference ratio	0.9	1.0	2.0	-0.9	0.9	0.5	-1.1	-1.2	-1.0	-1.1	0.9	-0.6	-1.1	-1.3	-1.4
Novelty place preference	1.0	1.1	1.9	-0.9	1.0	0.6	-1.1	-1.2	-1.0	-1.2	1.0	-0.5	-1.1	-1.3	-1.4
Time in novel zone, NPP test	1.4	1.5	2.1	-1.2	1.3	0.9	-1.3	-1.4	-1.3	-1.3	1.2	-0.3	-1.2	-1.4	-1.4
Total zone transitions, NPP test	0.1	0.1	0.4	-0.4	0.4	0.5	0.1	-0.3	-0.6	-0.2	0.4	0.3	-0.3	-0.2	-0.0
Total locomotion distance, NPP test	0.0	0.0	0.2	-0.0	-0.1	0.0	0.2	0.0	-0.2	0.3	0.2	0.2	0.2	0.2	0.4
Locomotion velocity, NPP test	0.1	0.2	0.4	0.5	-0.6	-0.5	0.6	0.5	0.2	0.6	-0.3	-0.1	0.4	0.4	0.5
Intraocular pressure	0.5	0.7	2.6	-0.3	0.5	0.9	-0.1	0.3	0.0	0.8	-0.0	1.6	0.9	1.1	1.4
Delta distance traveled before/after self-admin	0.8	0.9	2.2	1.3	-1.2	-1.2	0.8	0.9	1.1	0.2	-1.5	0.2	0.5	0.7	0.5
Delta ambulatory time before/after self-admin	0.6	0.7	2.2	0.8	-0.8	-0.7	0.7	0.8	0.9	0.0	-1.5	0.9	0.8	0.9	0.8
Parametrial fat weight	0.9	2.0	5.9	-0.2	-0.2	-1.3	-1.2	-1.1	-1.0	-1.6	1.0	-2.4	-1.1	-1.9	-2.1
Pavlov. Cond. lever latency	0.8	1.0	2.9	1.7	-1.1	-0.9	1.0	1.1	1.1	1.3	-0.6	-1.2	-0.0	0.1	0.1
Pavlov. Cond. magazine entry latency	0.4	0.5	1.4	-1.0	0.6	0.1	-0.9	-0.7	-0.7	-1.2	0.6	0.2	-0.1	-0.4	-0.6
Pavlov. Cond. change in total contacts	0.2	0.2	0.9	-0.7	0.4	0.4	-0.4	-0.3	-0.2	-0.4	-0.0	0.9	0.3	0.3	0.0
Pavlov. Cond. index score	0.4	0.5	1.5	-1.2	0.8	0.6	-0.7	-0.8	-0.7	-1.0	0.4	0.9	0.1	-0.0	-0.1
Pavlov. Cond. latency score	0.7	0.9	2.5	-1.6	1.1	0.8	-1.0	-1.1	-1.0	-1.3	0.6	1.0	0.0	-0.2	-0.3
Pavlov. Cond. lever contacts	1.1	1.4	3.3	-1.8	1.4	1.3	-1.2	-1.3	-1.3	-1.3	0.9	1.1	-0.4	-0.4	-0.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.6	0.6	-0.3	0.1	0.4	0.3	0.3	0.8	-0.2	-0.1	-0.0	0.2	0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.6	0.3	-0.5	-0.3	0.2	0.5	0.5	0.5	-0.6	0.5	0.6	0.7	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.5	-1.2	0.9	0.7	-0.8	-0.8	-0.8	-1.0	0.5	0.9	0.0	-0.1	-0.2
Pavlov. Cond. response bias	0.2	0.3	0.7	-0.8	0.5	0.4	-0.8	-0.5	-0.5	-0.8	0.2	0.7	0.1	-0.0	-0.1
Pavlov. Cond. lever latency	1.6	2.1	3.5	1.7	-1.7	-1.5	1.8	1.6	1.5	1.5	-1.9	-0.3	1.2	1.2	0.9
Pavlov. Cond. magazine entry latency	1.4	1.7	3.7	-0.8	1.4	1.4	-0.7	-1.4	-1.3	-0.3	1.4	-1.2	-1.9	-1.6	-1.5
Pavlov. Cond. change in total contacts	1.7	2.8	4.9	-1.3	1.5	1.3	-1.3	-1.7	-1.6	-1.2	2.2	-1.4	-2.1	-2.0	-1.8
Pavlov. Cond. index score	1.5	2.0	3.2	-1.4	1.6	1.5	-1.4	-1.6	-1.4	-1.1	1.8	-0.4	-1.6	-1.5	-1.2
Pavlov. Cond. latency score	1.5	1.9	3.0	-1.4	1.6	1.5	-1.4	-1.6	-1.4	-1.1	1.7	-0.4	-1.6	-1.4	-1.1
Pavlov. Cond. lever contacts	1.8	2.5	3.8	-1.9	1.9	1.6	-1.9	-1.8	-1.7	-1.6	1.9	0.4	-1.4	-1.3	-0.9
Pavlov. Cond. magazine entry number	0.7	0.9	2.1	0.5	-1.1	-1.3	0.2	1.0	0.9	-0.1	-1.1	0.8	1.5	1.1	0.7
Pavlov. Cond. intertrial magazine entries	1.9	2.9	6.0	1.9	-2.3	-2.5	1.7	1.9	1.8	0.9	-1.9	-0.2	1.7	1.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.1	3.6	-1.4	1.6	1.4	-1.4	-1.7	-1.5	-1.2	1.9	-0.5	-1.7	-1.6	-1.2
Pavlov. Cond. response bias	1.2	1.6	2.6	-1.2	1.4	1.2	-1.2	-1.4	-1.4	-1.0	1.6	-0.4	-1.5	-1.4	-1.1
Time in closed arm before self-admin	0.3	0.4	1.4	0.5	0.1	0.1	0.5	0.6	1.2	1.2	0.3	0.2	0.6	0.5	0.5
Time in closed arm after self-admin	0.1	0.1	0.7	0.3	0.1	0.1	-0.1	0.1	0.9	0.4	0.5	0.1	0.3	0.2	0.0
Time in open arm before self-admin	0.2	0.2	0.5	-0.1	0.1	-0.0	-0.1	-0.4	-0.7	-0.7	0.3	-0.6	-0.7	-0.7	-0.5
Time in open arm after self-admin	2.0	2.2	4.5	-1.1	1.1	0.7	-0.9	-1.6	-2.1	-1.8	0.9	-1.0	-1.9	-1.9	-1.7
Bone: periosteal estimation	1.3	2.7	7.8	-2.0	2.3	2.8	-1.7	-1.0	-0.9	-0.2	1.4	2.8	0.0	0.5	1.1
Bone: periosteal perimeter	1.6	2.8	5.6	-2.2	2.1	2.1	-2.4	-1.8	-1.6	-1.6	1.7	1.4	-0.8	-0.6	-0.3
Bone: post-yield work	0.7	1.0	3.3	-1.0	1.3	1.8	-0.9	-0.5	-0.4	0.3	0.4	1.8	0.4	0.7	0.9
Progressive ratio test 1 active lever presses	1.0	1.2	3.1	1.5	-1.7	-1.5	1.1	1.3	1.1	0.7	-0.8	-0.3	0.7	0.7	0.4
Progressive ratio test 1 breakpoint	0.9	1.1	2.8	1.4	-1.7	-1.4	1.0	1.3	1.1	0.8	-0.7	-0.2	0.7	0.8	0.5
Progressive ratio test 1 inactive lever presses	0.2	0.3	1.2	0.6	-0.6	-0.7	0.1	0.2	-0.2	0.1	-0.2	-1.1	-0.4	-0.5	-0.5
Progressive ratio test 2 active lever presses	0.8	1.0	1.7	0.6	-1.0	-0.7	0.5	1.1	0.9	0.8	-1.1	1.1	1.2	1.3	1.1
Progressive ratio test 2 breakpoint	0.8	1.0	1.6	0.6	-1.0	-0.6	0.5	1.1	0.8	0.8	-1.2	1.1	1.2	1.3	1.2
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.7	0.6	-0.8	-0.7	-0.2	0.3	-0.1	-0.3	-0.5	-0.1	-0.0	0.0	-0.2
Incentive Sensitization - Responses	0.3	0.4	2.3	-0.7	0.3	0.6	-0.4	0.0	-0.1	0.0	-0.2	1.5	0.6	0.8	0.9
Incentive Sensitization - Breakpoint	0.3	0.4	2.0	-0.8	0.3	0.6	-0.5	-0.0	-0.2	-0.0	-0.2	1.4	0.6	0.7	0.8
Sum of active levers in priming session hrs 5-6	2.0	1.9	3.0	1.3	-1.4	-1.0	1.5	1.7	1.0	1.4	-1.6	0.5	1.4	1.5	1.6
Progressive ratio	0.1	0.2	0.8	-0.3	0.5	0.4	-0.2	-0.5	-0.9	0.1	0.5	-0.2	-0.3	-0.4	-0.3
Food seeking constrained by brief footshock	0.0	0.1	0.2	0.3	-0.4	-0.4	-0.1	0.2	0.2	0.1	-0.0	-0.3	0.0	0.0	0.3
Seeking ratio, punishment vs. effort	0.2	0.3	0.8	0.6	-0.9	-0.8	0.2	0.5	0.9	-0.1	-0.3	-0.4	0.0	0.1	0.2
Retroperitoneal fat weight	0.3	1.1	3.3	-0.4	0.4	-0.2	-1.0	-1.1	-0.7	-0.8	0.8	-1.8	-1.2	-1.5	-1.6
Reaction time number correct	5.3	10.2	17.5	-4.2	3.8	3.7	-4.0	-3.5	-3.3	-3.6	3.4	2.3	-2.0	-1.8	-1.1
Reaction time mean minus median	0.2	0.5	2.2	0.6	-0.6	-1.2	1.1	0.1	0.3	0.1	-0.5	-1.5	-0.1	-0.5	-0.4
Reaction time mean minus median AUC	0.1	0.2	0.6	0.1	-0.3	-0.7	0.6	-0.1	0.1	-0.4	-0.1	-0.8	-0.1	-0.4	-0.4
Reaction time num false alarms	0.6	0.8	1.5	-0.8	0.9	0.3	-0.8	-1.0	-1.2	-0.8	0.9	-0.8	-0.7	-1.1	-1.2
Reaction time num false alarms AUC	0.6	1.0	1.7	-1.0	1.1	0.5	-1.1	-1.1	-1.3	-1.0	1.0	-0.6	-0.7	-1.1	-1.2
Reaction time trials correct on left	5.3	10.2	17.5	-4.2	3.8	3.7	-4.0	-3.5	-3.3	-3.6	3.4	2.3	-2.0	-1.8	-1.1
Reaction time trials on left	5.2	9.7	16.6	-4.1	3.7	3.5	-3.9	-3.4	-3.3	-3.5	3.3	2.2	-2.0	-1.8	-1.1
Reaction time mean	2.4	3.8	8.1	2.3	-2.2	-2.6	2.9	1.7	1.8	1.9	-1.7	-2.3	1.2	0.6	0.8
Reaction time mean AUC	1.9	3.0	6.8	2.0	-1.9	-2.2	2.6	1.5	1.6	1.9	-1.5	-2.0	1.1	0.6	0.7
Median of all reaction times	3.5	4.9	8.9	2.6	-2.6	-2.8	3.0	2.2	2.3	2.3	-2.0	-1.8	1.7	1.2	1.3
Reaction time omissions	1.8	2.7	7.1	1.8	-1.9	-2.7	1.8	1.5	1.7	1.3	-1.6	-1.3	1.6	0.7	0.7
Reaction time false alarm rate	0.9	1.2	3.6	1.5	-1.2	-1.6	1.2	0.9	0.7	1.0	-0.9	-1.9	0.3	-0.1	-0.6
Reaction time premature initiation rate	2.9	4.0	8.0	-1.3	1.6	1.3	-1.0	-2.1	-2.1	-1.2	1.7	-2.3	-2.8	-2.8	-2.8
Reaction time premature initiations	5.4	9.6	12.9	-3.2	3.3	2.9	-2.9	-3.6	-3.5	-2.9	3.1	-0.8	-3.6	-3.4	-3.0
Std. dev. reaction times	0.9	1.7	4.2	1.4	-1.4	-2.0	2.0	0.9	1.1	0.9	-1.1	-2.0	0.6	-0.0	0.0
Reaction time trials completed	5.2	9.7	16.6	-4.1	3.7	3.5	-3.9	-3.4	-3.3	-3.5	3.3	2.2	-2.0	-1.8	-1.1
Reaction time trials AUC	5.2	10.0	17.2	-4.1	3.7	3.5	-4.0	-3.4	-3.4	-3.6	3.3	2.3	-1.9	-1.7	-1.0
Run reversals in cocaine runway, females	0.3	0.3	0.7	0.8	-0.7	-0.7	0.4	0.5	0.6	0.2	-0.8	-0.6	-0.1	-0.1	0.1
Run reversals in cocaine runway, males	0.2	0.2	0.4	0.3	-0.3	-0.3	0.2	0.5	0.2	0.5	-0.1	0.2	0.6	0.6	0.5
Latency to leave start box in cocaine runway	0.2	0.2	0.4	-0.3	0.6	0.6	0.2	-0.2	-0.2	0.7	0.6	-0.4	-0.3	-0.3	-0.2
Latency to leave start box in cocaine runway, F	0.3	0.3	0.8	-0.7	0.8	0.9	-0.2	-0.3	-0.3	0.8	0.8	0.2	0.2	0.1	0.1
Latency to leave start box in cocaine runway, M	0.5	0.4	2.0	0.6	-0.5	-0.6	0.6	0.0	0.0	-0.1	-0.1	-1.4	-0.8	-0.9	-0.7
Std. dev. time between licks in bursts	1.3	1.8	3.9	-1.8	2.0	1.9	-1.2	-1.5	-1.2	-0.7	1.7	0.1	-0.9	-0.8	-0.7
Total sessions with >9 infusions	0.9	1.1	2.7	1.3	-1.7	-1.4	0.7	1.2	0.9	0.7	-1.0	-0.2	1.0	1.0	0.4
Short access day 1 total inactive lever presses	0.8	1.1	2.0	1.2	-1.4	-1.3	0.7	1.3	0.8	0.7	-1.4	-0.3	0.9	0.9	1.0
Short access day 10 total inactive lever presses	0.1	0.2	0.6	-0.5	0.7	0.5	-0.1	-0.3	-0.8	0.2	0.2	-0.2	-0.3	-0.3	0.2
Short access day 1 total infusions	0.8	1.0	2.1	1.2	-1.4	-1.5	1.1	1.0	0.6	1.0	-1.1	-1.2	0.6	0.4	0.1
Short access day 10 total infusions	0.7	1.0	1.4	1.1	-1.1	-0.8	0.6	1.1	0.8	0.9	-0.9	0.6	1.1	1.2	1.1
Short access total infusions	1.1	1.4	3.5	1.7	-1.9	-1.6	1.0	1.3	1.0	0.7	-1.4	-0.5	0.7	0.8	0.6
Short access day 1 locomotion	1.1	1.4	3.9	1.5	-1.3	-1.6	1.3	0.9	0.8	1.6	-0.7	-2.0	0.4	0.1	-0.3
Short access day 10 total locomotion	0.3	0.6	1.6	0.8	-0.6	-0.6	1.2	0.9	0.8	1.3	0.2	-0.6	0.7	0.5	0.2
Short access total locomotion	1.2	1.4	2.6	1.5	-1.6	-1.5	1.3	1.5	1.2	1.3	-0.6	-0.9	0.9	0.8	0.3
One hour access (0.3 mA shock)	0.2	0.2	0.6	-0.8	0.5	0.4	-0.1	-0.5	-0.7	-0.3	-0.1	0.6	0.1	-0.1	-0.1
Compulsive drug intake	1.4	1.7	4.4	-1.9	2.1	1.7	-1.1	-1.6	-1.2	-0.9	1.0	0.5	-0.8	-0.9	-0.8
One hour access (shock baseline)	0.6	0.9	1.7	0.8	-1.3	-1.1	0.8	1.1	0.7	0.3	-1.1	0.7	1.0	1.0	1.0
Social response proportion	0.3	0.4	2.1	-0.4	0.3	0.6	-0.2	0.2	-0.2	0.1	-0.2	1.5	0.5	0.7	0.8
Social responses	0.8	1.0	2.6	0.1	-0.0	0.6	0.6	0.8	0.7	1.3	-0.8	1.6	1.0	1.4	1.4
Social time	1.0	1.4	2.9	1.1	-0.8	-0.4	1.7	1.2	1.2	1.5	-1.6	0.5	1.0	1.1	1.4
Soleus weight	6.0	17.6	30.4	-5.5	5.1	4.6	-5.1	-4.5	-4.5	-4.3	4.7	2.2	-2.8	-2.7	-2.2
Bone: stiffness	0.5	0.8	2.7	-1.2	1.1	1.3	-1.1	-0.3	-0.2	0.0	0.4	1.6	0.6	0.6	0.8
Tibialis anterior weight	1.2	4.2	8.6	-2.9	2.5	2.2	-2.9	-1.7	-1.7	-2.3	2.0	2.7	-0.4	-0.5	-0.2
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.4	0.1	0.3	-0.6	-0.0	-0.3	-0.2	0.3	0.6	-0.0	0.1	0.1
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.7	0.3	-0.6	-0.3	-0.2	0.8	0.3	-0.1	-0.1	1.0	0.9	1.0	1.3
Time to tail flick, test, before self-admin	1.0	1.0	1.6	-0.9	1.1	0.7	-1.1	-1.1	-1.3	-0.4	0.7	-1.1	-1.0	-1.2	-1.1
Time to tail flick, test, after self-admin	0.3	0.3	0.8	-0.7	0.7	0.5	-0.5	-0.5	-0.9	0.1	0.7	-0.6	-0.4	-0.6	-0.6
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.6	-0.7	-0.5	0.2	0.5	0.2	-0.2	-0.2	0.2	0.3	0.4	0.6
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.2	0.1	0.1	0.3	0.0	-0.0	0.2	0.1	-0.1	0.0	-0.1	-0.1
Tibia length	1.2	3.4	7.6	-2.8	2.5	2.6	-2.3	-1.8	-1.5	-1.2	1.8	2.2	-0.1	-0.1	0.1
Ambulatory time before self-admin	0.8	1.2	2.6	-0.8	0.9	0.9	-1.0	-1.2	-1.1	-1.1	1.6	-0.3	-1.2	-1.2	-1.3
Ambulatory time after self-admin	0.1	0.1	0.4	0.4	-0.2	-0.2	0.0	-0.2	-0.1	-0.6	0.4	-0.0	-0.4	-0.3	-0.6
Bone: tissue strength	1.1	1.1	2.5	-0.6	1.0	1.2	-0.2	-1.0	-0.8	-0.0	1.0	-1.1	-1.6	-1.3	-1.5
Total heroin consumption	0.3	0.3	0.7	-0.2	0.6	0.4	-0.5	-0.7	-0.8	-0.1	0.3	-0.7	-0.7	-0.8	-0.6
Bone: trabecular number	1.7	2.8	5.6	-2.4	2.1	2.0	-2.3	-1.6	-1.7	-1.4	1.8	1.5	-0.6	-0.6	-0.5
Bone: trabecular spacing	0.6	0.8	3.4	0.1	-0.2	-0.7	-0.1	-0.6	-0.5	-0.9	0.3	-1.9	-1.0	-1.3	-1.3
Bone: trabecular thickness	1.5	1.8	4.3	0.4	-0.7	-0.5	0.2	1.3	1.3	0.8	-0.9	2.0	2.1	2.0	2.0
Bone: trabecular tissue density	0.3	0.5	1.0	0.8	-0.6	-0.4	0.9	0.8	0.7	0.7	-0.5	0.3	0.6	0.6	1.0
Water consumed over 24 hours	3.5	4.8	8.0	-2.8	2.5	2.4	-2.6	-2.4	-2.7	-2.5	2.1	1.4	-1.5	-1.3	-0.9
Number of responses in last shaping day	0.9	1.0	4.8	0.9	-1.0	-1.2	1.2	0.2	-0.1	0.8	-0.7	-2.2	-0.3	-0.6	-0.7