Cpeb3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	mRNA stability	Cpeb3	0.15	0.07	6.7e-16	0.21	0.22	0.22	0.21	1.3e-16	2.7e-17	3.5e-17	5.6e-17
2	Liver	intron excision ratio	chr1_244196039_244208505	0.06	0.05	3.3e-05	0.02	0.03	0.03	0.02	5.1e-03	2.1e-04	8.3e-04	1.3e-03
3	PL	mRNA stability	Cpeb3	0.08	0.05	1.4e-07	0.08	0.07	0.06	0.07	9.8e-09	8.5e-08	6.8e-07	1.0e-07
4	NAcc	mRNA stability	Cpeb3	0.08	0.05	9.0e-12	0.08	0.08	0.08	0.08	1.1e-11	1.7e-12	9.7e-12	3.2e-12
5	IC	mRNA stability	Cpeb3	0.14	0.09	2.1e-05	0.12	0.1	0.07	0.12	1.2e-05	6.4e-05	1.0e-03	9.7e-06
6	Adipose	mRNA stability	Cpeb3	0.04	0.03	3.1e-04	0.03	0.02	0.02	0	5.3e-04	5.3e-03	3.5e-03	7.7e-02
7	Liver	mRNA stability	Cpeb3	0.03	0.02	1.7e-03	-0	0.02	0.01	0	4.8e-01	2.2e-03	3.4e-02	8.1e-02
8	Liver	intron excision ratio	chr1_244186754_244195925	0.06	0.05	9.4e-05	0.03	0.03	0.04	0.02	4.7e-04	3.3e-04	7.0e-05	2.5e-03
9	OFC	mRNA stability	Cpeb3	0.29	0.17	1.6e-04	0.04	0.09	0.12	0.08	4.3e-02	3.4e-03	7.5e-04	6.6e-03
10	Brain	mRNA stability	Cpeb3	0.14	0.08	4.1e-10	0.11	0.11	0.09	0.1	2.5e-10	2.9e-10	7.9e-09	8.0e-10
11	BLA	gene expression	Cpeb3	0.11	0.08	9.5e-04	0.04	0.05	0.04	0.04	2.2e-03	1.4e-03	3.1e-03	5.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	6.4	11.9	18.1	-4.3	-3.9	3.6	-3.4	-3.8	4.2	-3.8	-3.1	3.1	2.6	0.1
Area under the delay curve	0.4	0.6	1.1	0.9	1.0	-0.8	0.7	0.7	-0.5	1.0	0.3	-0.8	-0.9	0.4
BMI with tail	0.2	0.8	2.6	-0.9	-0.7	0.4	-0.4	-0.8	0.9	-0.9	-1.6	1.1	0.9	-0.4
BMI without tail	0.1	0.3	2.8	-0.1	-0.2	0.1	-0.3	-0.3	-0.2	-0.0	-1.7	-0.5	0.1	0.1
Body weight	1.2	5.2	14.3	-2.5	-2.5	2.5	-2.8	-2.8	1.9	-1.8	-3.8	0.1	0.8	1.1
Weight adjusted by age	0.1	0.2	0.5	0.2	0.6	-0.5	0.6	0.3	0.5	0.3	0.2	0.7	-0.2	0.0
Bone surface	4.6	9.0	13.0	-3.6	-3.6	2.9	-2.9	-3.0	3.0	-3.6	-3.2	2.7	2.8	-0.6
Bone volume	5.2	10.3	15.0	-3.9	-3.7	3.4	-3.4	-3.6	3.5	-3.5	-3.7	2.3	2.3	0.2
Breakpoint value in progressive ratio session	0.2	0.4	1.5	-0.0	0.3	0.3	-0.3	-0.4	0.5	0.6	-0.5	-0.8	-1.1	1.2
Number of licking bursts	1.1	3.2	4.8	2.2	2.2	-2.1	2.0	2.0	-1.9	2.0	1.6	-1.0	-1.5	-0.0
Context. condit. distance diff. score	1.6	1.9	3.5	-1.4	-1.1	1.8	-1.9	-1.8	1.6	-0.4	-1.2	-0.5	-0.5	1.8
Locomotion velocity, session 1	2.2	2.5	5.3	1.5	1.2	-2.2	2.2	1.8	-1.7	0.4	0.9	1.2	0.8	-2.3
Locomotion distance, session 1	0.3	0.4	1.7	0.5	0.5	-0.9	0.8	0.5	-0.4	0.2	1.3	0.4	0.2	-0.6
Locomotion velocity, session 2	0.6	0.7	1.6	0.9	0.7	-1.3	1.2	1.0	-1.2	0.4	0.1	0.0	0.2	-1.1
Locomotion distance, session 2	0.4	0.5	1.1	0.8	0.8	-0.9	0.5	0.6	-0.9	0.9	0.4	-1.1	-0.7	0.2
Locomotion velocity, session 3	0.2	0.2	0.8	-0.4	-0.4	0.6	-0.6	-0.5	0.1	-0.2	-0.9	-0.5	-0.1	0.4
Locomotion distance, session 3	0.9	1.0	2.2	-0.6	-0.6	1.1	-1.3	-1.0	0.3	0.1	-1.1	-1.4	-0.8	1.5
Stereotopy head waving bouts, day 3	0.4	0.5	1.5	-0.2	-0.3	-0.2	0.3	0.2	-0.0	-0.7	0.3	1.2	1.1	-1.2
Stereotopy head waving duration, day 3	0.3	0.4	1.4	-0.0	-0.0	-0.3	0.5	0.3	0.2	-0.5	0.7	1.2	0.8	-1.0
Locomotion velocity, session 7	0.8	0.9	3.3	-0.2	0.2	0.6	-0.7	-0.7	0.8	0.7	-0.2	-1.2	-1.4	1.8
Locomotion distance, session 7	0.6	0.8	2.7	-0.5	-0.1	0.8	-0.9	-0.9	0.9	0.4	-0.5	-0.9	-1.1	1.6
Stereotopy head waving bouts, day 7	0.2	0.3	0.9	-0.0	-0.3	-0.1	0.1	0.3	-0.6	-0.5	-0.4	0.4	0.8	-1.0
Stereotopy head waving duration, day 7	0.7	0.9	2.3	-0.6	-1.0	0.3	-0.2	-0.1	-0.2	-1.3	-1.2	1.1	1.5	-1.4
Locomotion velocity, session 8	0.2	0.2	0.4	-0.6	-0.5	0.7	-0.6	-0.6	0.4	-0.4	-0.4	0.2	-0.1	0.3
Locomotion distance, session 8	0.5	0.7	2.8	-0.2	0.1	0.4	-0.7	-0.7	0.6	0.7	-0.2	-1.1	-1.3	1.7
Degree of sensitization distance	0.5	0.6	1.1	0.7	1.0	-0.6	0.7	0.5	0.1	1.0	1.1	-0.2	-1.0	0.6
Degree of sensitization stereotypy	0.4	0.5	1.1	-0.5	-0.9	0.5	-0.4	-0.3	-0.2	-1.0	-0.9	0.5	1.1	-0.8
Conditioned locomotion	0.3	0.4	0.8	-0.6	-0.4	0.7	-0.7	-0.7	0.9	-0.2	-0.7	0.1	-0.2	0.8
Cocaine response after cond. corrected	0.1	0.1	0.9	-0.2	-0.2	0.2	-0.0	-0.0	-0.1	-0.3	-0.9	0.4	0.4	-0.4
Cocaine response after cond. not corrected	0.1	0.1	0.6	-0.2	-0.2	0.5	-0.4	-0.2	0.0	0.1	-0.8	-0.5	-0.2	0.5
Cocaine response before conditioning	0.4	0.5	2.4	0.5	0.5	-0.0	-0.1	0.1	-0.5	0.9	0.3	-1.6	-1.0	1.0
Saline control response	0.6	0.9	2.7	0.6	1.0	-0.2	0.2	0.3	0.2	1.3	0.6	-1.1	-1.7	1.4
Bone: connectivity density	4.1	6.5	9.5	-3.1	-2.9	2.4	-2.2	-2.5	3.0	-3.1	-2.0	3.0	2.5	-0.6
Bone: cortical apparent density	1.1	1.8	4.7	1.4	1.4	-1.4	1.7	1.7	-1.3	0.9	2.2	0.1	-0.2	-0.9
Bone: cortical area	3.7	6.0	15.9	-2.6	-2.6	2.9	-3.1	-2.9	2.1	-1.8	-4.0	-0.1	0.7	1.5
Bone: cortical porosity	0.1	0.1	0.2	0.4	0.5	-0.3	0.3	0.3	-0.1	0.4	0.4	-0.2	-0.4	0.2
Bone: cortical porosity	0.0	0.0	0.1	-0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	-0.2	-0.2	-0.2	0.3
Bone: cortical thickness	0.7	1.2	5.5	-0.7	-0.7	1.1	-1.3	-1.0	0.4	-0.1	-2.3	-1.1	-0.4	1.2
Bone: cortical thickness	0.4	0.4	0.9	0.8	0.8	-0.6	0.5	0.5	-0.5	0.9	0.1	-0.9	-0.8	0.4
Bone: cortical tissue density	1.2	2.0	5.2	1.5	1.4	-1.5	1.8	1.8	-1.3	1.0	2.3	0.1	-0.2	-1.0
Condit. Reinf. active minus inactive responses	0.8	0.9	1.6	1.2	1.1	-1.0	0.8	0.9	-1.2	1.2	0.0	-1.3	-0.9	0.2
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.7	0.9	0.6	-1.0	1.0	1.1	-1.3	0.4	0.1	-0.1	0.3	-1.0
Condit. Reinf. active responses	0.4	0.5	2.0	0.3	0.4	-0.0	-0.2	-0.1	-0.3	0.8	-0.3	-1.4	-1.1	1.1
Condit. Reinf. inactive responses	0.6	0.8	2.3	-0.8	-0.5	1.0	-1.2	-1.2	1.0	0.1	-0.3	-0.7	-0.8	1.5
Incentive salience index mean	1.4	1.8	4.2	1.5	1.4	-1.1	0.8	1.0	-1.4	1.8	0.1	-2.1	-1.6	0.9
Condit. Reinf. lever presses	1.7	2.5	4.4	1.8	1.8	-1.5	1.2	1.3	-1.6	2.1	1.0	-2.1	-1.7	0.7
Condit. Reinf. active minus inactive responses	0.5	0.8	2.6	-0.1	0.0	0.7	-0.8	-0.5	0.4	0.6	-0.9	-1.3	-1.2	1.6
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.8	0.3	0.4	0.1	-0.1	0.1	-0.0	0.7	-0.2	-0.8	-0.8	0.9
Condit. Reinf. active responses	1.2	1.7	3.6	-1.2	-1.2	1.6	-1.8	-1.5	1.2	-0.6	-1.9	-0.7	-0.2	1.4
Condit. Reinf. inactive responses	1.2	1.7	3.2	-1.5	-1.6	1.4	-1.7	-1.6	1.1	-1.2	-1.8	0.0	0.6	0.4
Condit. Reinf. lever presses	0.1	0.1	0.6	-0.2	-0.3	0.0	-0.3	-0.3	-0.1	-0.2	-0.8	-0.0	0.1	0.0
Condit. Reinf. lever reinforcers received	0.7	0.9	2.1	-0.8	-0.7	1.1	-1.3	-1.1	0.8	-0.2	-1.5	-0.7	-0.4	1.2
Conditioned reinforcement - actives	0.5	2.0	3.2	-1.7	-1.8	1.4	-1.4	-1.4	1.7	-1.8	-0.6	1.4	1.4	-0.3
Conditioned reinforcement - inactives	0.5	1.4	2.4	-1.5	-1.3	0.9	-1.0	-1.2	1.6	-1.4	-0.4	1.4	1.1	-0.2
Conditioned locomotion	1.7	2.5	4.5	-1.8	-1.8	1.2	-1.1	-1.3	1.5	-2.1	-1.1	2.0	1.9	-1.0
Patch foraging indifference point 0 sec	0.1	0.3	1.0	-0.2	-0.6	0.2	-0.1	0.0	-0.3	-0.7	-0.0	0.3	1.0	-0.9
Patch foraging indifference point AUC	0.3	0.8	1.3	1.1	0.9	-0.7	0.7	0.9	-1.1	1.0	0.7	-1.1	-0.7	0.1
Delay disc. indifference point, 0s delay	1.2	1.3	4.1	0.7	1.1	-0.2	0.1	0.0	0.4	1.6	-0.4	-1.5	-2.0	1.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.3	-0.4	0.2	-0.3	-0.3	0.2	-0.4	-0.2	0.3	0.3	-0.2
Delay disc. indifference point, 2s delay	0.3	0.3	0.7	0.6	0.8	-0.7	0.8	0.6	-0.1	0.6	0.8	0.1	-0.4	-0.1
Delay disc. indifference point, 24s delay	0.9	1.5	2.9	1.4	1.2	-0.9	0.7	1.1	-1.4	1.4	1.3	-1.7	-1.3	0.5
Delay disc. indifference point, 4s delay	0.6	0.6	1.6	0.6	0.8	-0.3	0.2	0.2	-0.0	1.1	-0.5	-1.1	-1.3	1.0
Delay disc. indifference point, 8s delay	1.3	2.1	3.4	1.8	1.8	-1.8	1.8	1.7	-1.5	1.6	1.1	-0.8	-0.9	-0.4
Indifference point function ln k	0.4	1.2	2.1	-1.4	-1.3	1.3	-1.3	-1.3	1.3	-1.2	-0.7	0.7	0.7	0.3
Indifference point function log k	0.4	1.2	2.1	-1.4	-1.3	1.3	-1.3	-1.3	1.3	-1.2	-0.7	0.7	0.7	0.3
Patch foraging total patch changes 0 sec	0.1	0.3	1.1	-0.4	-0.7	0.3	-0.2	-0.1	-0.2	-0.8	-0.1	0.4	1.1	-0.9
Patch foraging total patch changes 12 sec	0.8	1.1	1.9	1.3	1.0	-1.1	1.3	1.4	-1.3	0.7	1.1	-0.3	-0.2	-0.9
Patch foraging total patch changes 18 sec	0.1	0.3	0.6	0.6	0.5	-0.7	0.6	0.6	-0.5	0.4	0.7	-0.3	-0.1	-0.4
Patch foraging total patch changes 24 sec	0.1	0.2	1.2	0.4	0.2	-0.1	-0.0	0.4	-0.9	0.4	-0.1	-1.1	-0.3	0.2
Patch foraging total patch changes 6 sec	0.4	0.6	2.2	0.8	0.2	-0.7	0.7	0.9	-1.5	0.0	0.5	-0.2	0.6	-1.3
Patch foraging time to switch 0 sec	0.3	1.2	2.0	1.3	1.4	-1.3	1.4	1.3	-1.1	1.1	1.0	-0.2	-0.6	-0.3
Patch foraging water rate 0 sec	0.1	0.3	0.6	-0.7	-0.7	0.5	-0.8	-0.7	0.8	-0.6	0.3	0.1	0.3	0.2
Patch foraging water rate 12 sec	0.2	0.9	2.8	-1.1	-1.1	0.7	-1.0	-1.1	0.5	-1.0	-1.7	0.4	0.9	-0.1
Patch foraging water rate 18 sec	0.4	0.8	1.5	-1.1	-1.0	1.1	-1.2	-1.2	0.8	-0.7	-1.0	-0.0	0.3	0.6
Patch foraging water rate 24 sec	1.0	1.5	2.8	-1.1	-1.0	1.5	-1.6	-1.6	1.1	-0.4	-1.7	-0.6	-0.3	1.4
Patch foraging water rate 6 sec	0.2	0.4	1.0	-0.6	-0.7	0.2	-0.3	-0.4	0.1	-0.9	0.1	0.8	1.0	-0.7
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	0.1	0.1	0.1	-0.2	-0.0	-0.0	0.3	0.4	-0.6	-0.4	0.5
Distance traveled before self-admin	0.3	0.6	1.1	0.9	1.0	-0.6	0.7	0.8	-0.6	1.1	0.7	-0.9	-0.9	0.3
Distance traveled after self-admin	0.2	0.4	2.5	-0.2	0.1	-0.2	0.5	0.1	0.7	-0.4	-0.2	1.6	0.6	-0.7
Extensor digitorum longus weight	0.5	2.1	7.7	-0.5	-0.1	1.2	-1.5	-1.2	0.6	0.8	-1.4	-2.0	-1.8	2.8
Bone: elastic displacement	2.4	3.1	6.1	1.6	1.5	-2.3	2.4	2.0	-1.5	0.7	2.5	0.9	0.4	-1.9
Bone: elastic work	1.4	1.8	3.6	1.0	1.1	-1.8	1.9	1.5	-0.8	0.2	1.8	1.3	0.6	-1.7
Bone: endosteal estimation	4.1	10.0	15.2	-3.9	-3.8	3.7	-3.6	-3.6	3.4	-3.5	-2.7	2.0	2.3	0.4
Bone: endosteal perimeter	4.3	10.4	15.7	-4.0	-3.8	3.7	-3.6	-3.7	3.7	-3.5	-2.8	2.3	2.3	0.4
Epididymis fat weight	0.4	2.2	3.8	-1.9	-1.5	1.6	-1.6	-1.8	2.0	-1.3	-1.5	1.1	0.6	0.7
Delta time in closed arm before/after self-admin	0.3	0.3	1.2	0.7	0.3	-0.3	0.4	0.6	-1.1	0.3	0.4	-0.4	-0.2	-0.3
Delta time in open arm before/after self-admin	0.3	0.4	0.8	0.6	0.9	-0.6	0.7	0.6	0.2	0.8	0.8	-0.1	-0.7	0.3
Diff in mean of infusions in LGA sessions	0.1	0.3	0.6	-0.5	-0.4	0.7	-0.6	-0.7	0.7	-0.2	-0.1	-0.0	-0.2	0.6
Delay discount exponential model param	0.4	0.6	1.1	-0.9	-1.0	0.7	-0.7	-0.7	0.6	-1.0	-0.3	0.9	0.9	-0.4
Extinction: sum of active levers before priming	0.2	0.4	0.9	-0.3	-0.3	0.7	-0.7	-0.6	0.3	0.1	-1.0	-0.8	-0.5	0.9
Active lever presses in extinction session 6	0.9	1.0	3.8	-0.1	0.5	0.6	-0.4	-0.5	1.4	0.9	-0.3	-0.7	-1.6	1.9
Bone: final force	1.6	2.5	4.2	-1.8	-1.9	1.9	-2.0	-1.8	1.4	-1.5	-2.0	0.2	0.9	0.6
Bone: final moment	1.6	2.6	4.4	-1.9	-2.1	1.8	-1.9	-1.7	1.4	-1.8	-1.8	0.7	1.4	0.1
Food consumed during 24 hour testing period	0.0	0.1	0.4	0.0	-0.2	-0.1	-0.2	-0.1	-0.6	-0.1	0.2	-0.5	0.2	-0.2
Glucose	0.1	0.1	0.4	-0.3	-0.5	0.3	-0.5	-0.3	-0.0	-0.4	-0.6	-0.2	0.4	-0.0
Heart weight	1.7	2.7	7.4	-1.1	-1.7	0.4	-0.4	-0.5	-0.4	-2.2	-1.7	2.0	2.7	-2.4
Delay discount hyperbolic model param	0.4	0.6	1.0	-0.9	-1.0	0.8	-0.8	-0.8	0.6	-1.0	-0.4	0.7	0.8	-0.2
Intermittent access intake day 1-15 change	0.7	4.1	6.8	-2.4	-2.6	2.1	-2.0	-2.0	1.7	-2.6	-1.6	1.9	2.1	-0.6
Intermittent access intake escalation	0.7	3.6	5.9	-2.3	-2.4	2.2	-2.0	-2.0	1.7	-2.4	-1.5	1.6	1.7	-0.2
Intermittent access intake escalation 2	0.7	1.2	2.0	-1.2	-1.4	1.4	-1.1	-1.0	1.0	-1.3	-0.8	0.9	0.9	-0.2
Intermitt. access day 1 inactive lever presses	0.1	0.8	1.8	1.0	0.9	-1.0	1.1	1.0	-0.9	0.6	1.4	-0.0	-0.3	-0.6
Intermitt. access day 15 inactive lever presses	0.5	2.8	5.4	-1.9	-2.0	1.3	-1.2	-1.4	1.7	-2.3	-0.5	2.3	2.0	-0.9
Intermitt. access escalation Index	0.2	0.6	1.1	1.1	0.9	-0.4	0.6	0.8	-0.8	1.0	0.1	-0.9	-1.0	0.3
Intermittent access day 1 total infusions	0.5	1.4	3.2	-1.5	-1.2	1.1	-1.1	-1.3	1.8	-1.2	-0.4	1.2	0.8	0.2
Intermittent access day 15 total infusions	2.8	6.9	10.6	-3.2	-3.3	2.9	-2.9	-2.9	2.8	-3.1	-1.9	2.1	2.1	0.1
Intermittent access terminal intake (last 3 days)	2.8	4.9	7.4	-2.7	-2.7	2.3	-2.2	-2.3	2.4	-2.7	-1.3	2.2	2.1	-0.3
Intermittent access total infusions	2.9	3.4	5.4	-2.3	-2.2	1.9	-2.0	-2.1	2.3	-2.1	-1.1	1.6	1.4	0.2
Intermittent access day 1 locomotion	0.7	1.3	2.3	-1.5	-1.3	1.0	-1.2	-1.3	1.5	-1.3	-0.8	0.9	0.9	0.1
Intermittent access day 15 total locomotion	1.2	4.5	7.2	-2.6	-2.5	1.8	-1.8	-2.1	2.3	-2.7	-1.4	2.4	2.3	-0.7
Intermittent access total locomotion	2.3	2.8	5.2	-2.1	-1.8	1.5	-1.5	-1.8	2.3	-1.9	-1.1	1.9	1.3	-0.0
Intermittent access standard deviation	0.6	3.0	5.2	-2.0	-2.3	2.0	-1.9	-1.8	1.4	-2.1	-1.5	1.2	1.6	-0.3
Left kidney weight	0.5	4.1	16.4	-2.0	-2.2	2.1	-2.4	-2.2	1.1	-1.7	-4.0	-0.1	1.0	0.6
Right kidney weight	0.3	1.9	7.0	-1.3	-1.6	1.5	-1.8	-1.5	0.3	-1.0	-2.7	-0.6	0.6	0.5
Cocaine induced anxiety	0.1	0.3	1.1	-0.0	0.4	0.1	-0.1	-0.3	0.7	0.5	-0.9	-0.3	-0.8	1.0
Post-drug Anxiety	0.5	0.6	1.3	-0.9	-0.7	0.5	-0.5	-0.7	0.8	-0.8	-1.1	0.9	0.7	-0.1
Baseline Anxiety	0.8	1.3	2.9	-1.2	-1.4	0.7	-0.8	-0.8	0.5	-1.7	-0.3	1.3	1.7	-1.1
Tail length	0.3	1.8	3.6	-0.9	-1.0	1.6	-1.9	-1.5	0.5	-0.1	-1.4	-1.8	-0.9	1.9
Length with tail	1.3	5.7	10.9	-2.5	-2.6	3.1	-3.3	-2.9	1.9	-1.6	-3.3	-0.7	0.2	1.9
Length without tail	1.4	7.5	12.1	-3.2	-2.9	3.5	-3.5	-3.4	2.9	-2.2	-3.3	0.6	0.7	1.8
Times rat made contact with spout	0.8	0.9	2.2	0.7	1.1	-0.8	0.5	0.4	0.0	1.3	1.4	-0.9	-1.5	1.0
Lifetime Intake	2.8	3.4	5.3	-2.3	-2.2	1.9	-1.9	-2.0	2.3	-2.1	-1.1	1.8	1.5	0.1
Liver weight, left	0.8	1.4	2.6	-1.4	-1.5	1.5	-1.6	-1.5	1.0	-1.2	-1.2	0.2	0.6	0.4
Liver weight, right	1.4	2.5	3.8	-2.0	-1.9	1.9	-1.8	-1.8	1.7	-1.7	-1.4	1.2	1.0	0.4
Locomotor activity	0.4	0.6	1.2	0.8	0.8	-0.9	1.0	1.1	-0.9	0.5	0.8	-0.0	-0.0	-0.7
Locomotor testing distance	0.4	1.0	1.8	1.0	0.8	-1.2	1.3	1.3	-1.3	0.4	1.0	0.2	0.3	-1.2
Locomotor testing rearing	0.0	0.2	0.5	0.1	0.2	0.4	-0.1	-0.1	0.2	0.4	-0.1	-0.5	-0.7	0.7
Locomotion in novel chamber	0.6	0.8	1.6	-1.0	-0.8	1.1	-0.9	-1.0	1.2	-0.6	-1.3	0.5	0.0	0.7
Locomotion in novel chamber post-restriction	0.6	1.8	3.6	-1.4	-1.2	1.9	-1.9	-1.6	1.2	-0.5	-1.4	-0.6	-0.3	1.6
Fecal boli incidents, locomotor time 1	0.1	0.3	1.3	0.1	0.5	0.1	-0.1	-0.1	0.4	0.7	-0.1	-0.5	-0.9	1.1
Change in fecal boli incidents, locomotor task	0.2	0.2	1.0	0.3	0.1	-0.3	0.2	0.4	-1.0	0.1	0.5	-0.5	0.0	-0.3
Time >=10cm from walls, locomotor time 1	2.5	3.1	7.8	-1.5	-1.5	2.0	-2.4	-2.1	1.0	-0.5	-2.8	-1.3	-0.4	2.1
Bouts of movement, locomotor time 1	0.2	0.2	0.9	-0.5	-0.3	0.6	-0.5	-0.5	0.9	-0.2	-0.4	0.3	-0.1	0.6
Total resting periods, locomotor time 1	0.3	0.3	1.1	-0.5	-0.3	0.7	-0.5	-0.6	1.0	-0.2	-0.6	0.2	-0.2	0.7
Rest time, locomotor task time 1	0.2	0.3	0.6	0.4	0.6	-0.5	0.7	0.6	0.2	0.3	0.7	0.8	-0.1	-0.2
Distance moved, locomotor task time 1	0.2	0.7	4.0	0.4	0.2	-0.1	-0.4	0.0	-1.1	0.7	-0.2	-2.0	-0.7	0.8
Vertical activity count, locomotor time 1	0.0	0.2	0.5	-0.4	-0.7	0.4	-0.6	-0.5	-0.1	-0.5	-0.4	-0.4	0.4	-0.1
Time >=10cm from walls, locomotor time 2	0.3	0.8	2.7	0.3	0.4	0.3	-0.4	-0.2	-0.3	1.0	-0.6	-1.7	-1.3	1.6
Bouts of movement, locomotor time 2	0.7	2.4	4.4	1.9	2.1	-1.6	1.9	1.9	-0.9	1.8	1.4	-0.6	-1.2	-0.0
Total resting periods, locomotor time 2	0.6	2.4	4.5	1.9	2.1	-1.6	1.9	1.8	-0.9	1.9	1.4	-0.7	-1.4	0.2
Rest time, locomotor task time 2	0.2	0.3	1.1	0.3	0.6	-0.0	0.1	0.2	0.2	0.7	0.2	-0.4	-1.0	1.0
Distance moved, locomotor task time 2	0.2	0.3	2.1	0.1	-0.1	0.1	-0.5	-0.3	-0.6	0.3	-0.2	-1.5	-0.4	0.6
Vertical activity count, locomotor time 2	0.1	0.3	0.6	0.5	0.3	-0.7	0.6	0.4	-0.6	0.2	0.7	-0.2	0.3	-0.7
Light reinforcement 1	0.1	0.4	1.8	-0.5	-0.3	0.2	0.0	-0.2	0.9	-0.7	0.2	1.3	0.6	-0.5
Light reinforcement 2	1.5	3.3	6.9	1.8	2.0	-2.4	2.6	2.3	-1.1	1.1	2.2	1.1	-0.0	-1.6
Bone: marrow area	4.3	10.6	16.1	-4.0	-3.9	3.8	-3.6	-3.7	3.5	-3.6	-2.7	2.1	2.3	0.4
Bone: maximum diameter	7.8	15.6	22.3	-4.7	-4.5	4.7	-4.6	-4.7	4.3	-3.9	-4.5	2.0	2.1	1.2
Bone: maximum force	2.6	5.2	8.1	-2.7	-2.8	2.6	-2.7	-2.5	2.2	-2.5	-2.4	1.1	1.7	0.3
Bone: maximum moment	2.8	5.3	8.8	-2.8	-3.0	2.5	-2.5	-2.4	2.1	-2.8	-2.2	1.5	2.1	-0.2
Mean time between licks in bursts	0.2	1.2	3.7	0.9	0.4	-1.2	1.1	1.2	-1.9	-0.1	0.2	0.5	0.8	-1.7
Mean num. licks in bursts	0.6	1.5	3.1	-1.6	-1.4	1.4	-1.5	-1.6	1.8	-1.1	-0.6	0.4	0.5	0.6
Cd content in liver	0.9	1.0	3.5	0.7	0.1	-0.9	0.9	1.0	-1.4	-0.4	-0.7	0.5	1.2	-1.9
Co content in liver	0.9	1.1	4.2	0.3	-0.1	-0.9	0.9	0.9	-0.9	-0.7	0.1	1.2	1.5	-2.1
Cu content in liver	1.8	2.2	5.2	1.0	0.8	-1.6	1.8	1.6	-1.1	-0.1	2.0	1.4	1.1	-2.3
Fe content in liver	0.9	1.1	2.9	1.2	0.9	-1.0	1.1	1.2	-1.7	0.7	1.5	-0.6	-0.1	-0.7
K content in liver	2.2	2.1	3.9	1.5	1.9	-1.2	1.2	1.1	-0.4	2.0	1.7	-1.2	-2.0	1.1
Mg content in liver	0.9	0.9	1.6	1.1	1.3	-1.1	1.1	1.1	-0.7	1.1	1.1	-0.5	-0.8	0.0
Mn content in liver	0.9	1.0	1.9	1.2	1.2	-1.3	1.4	1.3	-0.9	0.8	0.7	-0.0	-0.3	-0.7
Na content in liver	2.2	2.4	4.1	1.8	1.9	-1.5	1.4	1.5	-1.4	2.0	1.3	-1.6	-1.7	0.7
Rb content in liver	0.1	0.2	0.4	-0.5	-0.5	0.6	-0.6	-0.5	0.1	-0.3	-0.1	-0.1	0.0	0.3
Se content in liver	16.4	19.4	31.4	5.3	4.6	-5.5	5.5	5.6	-5.5	3.5	4.0	-1.4	-1.0	-3.1
Sr content in liver	1.1	1.0	3.3	-0.0	-0.2	-0.6	0.8	0.5	-0.0	-0.8	0.4	1.8	1.4	-1.8
Zn content in liver	6.9	8.1	12.0	3.5	3.5	-3.3	3.2	3.2	-2.9	3.1	2.7	-1.9	-2.0	-0.4
Bone: minimum diameter	7.0	13.5	21.5	-4.3	-4.5	4.5	-4.6	-4.3	3.3	-3.6	-4.3	0.9	2.0	1.3
Time in familiar zone, hab. session 1	0.2	0.2	0.6	-0.4	-0.5	0.2	-0.1	-0.1	0.1	-0.7	-0.3	0.8	0.7	-0.7
Time in novel zone, hab. session 1	0.6	0.6	1.0	0.9	1.0	-0.8	0.7	0.7	-0.7	1.0	1.0	-0.7	-0.7	0.3
Total zone transitions, hab. session 1	0.1	0.1	0.5	-0.2	-0.2	-0.0	-0.1	-0.2	0.2	-0.2	0.7	0.4	0.2	-0.1
Total locomotion distance, hab. session 1	1.0	1.4	3.8	1.2	1.4	-1.4	1.2	1.0	-0.7	1.3	1.9	-0.7	-1.0	0.2
Locomotion velocity, hab. session 1	1.5	2.2	5.5	1.5	1.7	-1.6	1.4	1.2	-0.9	1.7	2.3	-1.1	-1.4	0.4
Time in familiar zone, hab. session 2	0.3	0.4	1.3	0.4	0.2	-0.7	0.7	0.7	-0.6	-0.2	-0.0	0.6	0.6	-1.1
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.3	-0.2	0.3	-0.3	-0.3	0.3	-0.2	0.3	0.1	0.1	0.2
Total zone transitions, hab. session 2	0.2	0.2	0.8	0.4	0.0	-0.4	0.4	0.4	-0.9	-0.1	0.2	0.1	0.6	-0.8
Total locomotion distance, hab. session 2	0.4	0.5	0.9	0.8	0.7	-0.9	0.8	0.8	-0.9	0.6	0.6	-0.4	-0.1	-0.4
Locomotion velocity, hab. session 2	0.5	0.7	1.0	1.0	1.0	-1.0	0.8	0.8	-0.9	0.9	0.8	-0.8	-0.6	0.0
Novel to familiar place preference ratio	0.4	0.5	2.0	-0.6	-0.1	0.5	-0.4	-0.7	1.4	-0.0	1.1	0.3	-0.5	0.9
Novelty place preference	0.5	0.6	2.3	-0.7	-0.2	0.5	-0.5	-0.8	1.5	-0.2	1.3	0.5	-0.4	0.8
Time in novel zone, NPP test	0.4	0.5	2.1	-0.5	-0.0	0.4	-0.3	-0.6	1.3	-0.0	1.4	0.4	-0.4	0.8
Total zone transitions, NPP test	0.5	0.8	1.2	1.0	0.9	-0.9	0.7	0.7	-1.1	1.0	0.7	-1.1	-0.8	0.2
Total locomotion distance, NPP test	1.9	2.7	5.1	1.8	1.9	-1.9	1.6	1.5	-1.5	1.8	2.3	-1.2	-1.4	0.1
Locomotion velocity, NPP test	1.9	2.7	4.6	1.8	1.9	-1.8	1.5	1.4	-1.4	2.0	2.1	-1.4	-1.7	0.5
Intraocular pressure	0.3	0.4	0.8	-0.8	-0.8	0.3	-0.5	-0.5	0.6	-0.9	-0.1	0.7	0.9	-0.4
Delta distance traveled before/after self-admin	2.1	2.3	4.3	-1.8	-1.5	1.1	-1.1	-1.5	2.0	-1.7	-1.4	2.1	1.4	-0.3
Delta ambulatory time before/after self-admin	1.6	2.8	4.8	-2.0	-1.7	1.3	-1.3	-1.7	2.1	-1.9	-1.6	2.2	1.5	-0.2
Parametrial fat weight	0.5	1.2	4.6	1.1	0.9	-0.4	0.3	0.6	-1.4	1.4	-0.3	-2.1	-1.3	0.9
Pavlov. Cond. lever latency	1.8	2.3	5.6	-1.3	-1.5	0.7	-0.4	-0.5	0.6	-2.1	-0.8	2.4	2.3	-1.9
Pavlov. Cond. magazine entry latency	0.8	1.0	2.6	1.2	0.9	-1.0	0.6	0.7	-1.4	1.1	-0.5	-1.6	-0.9	0.2
Pavlov. Cond. change in total contacts	0.9	1.0	2.8	1.3	0.9	-1.0	0.7	1.0	-1.7	1.0	0.2	-1.4	-0.6	-0.2
Pavlov. Cond. index score	1.5	1.9	6.0	1.3	1.3	-0.8	0.4	0.6	-1.0	1.8	-0.1	-2.4	-2.0	1.4
Pavlov. Cond. latency score	1.8	2.3	7.3	1.3	1.4	-0.7	0.3	0.5	-0.9	2.1	0.1	-2.7	-2.3	1.8
Pavlov. Cond. lever contacts	1.7	2.1	5.3	1.4	1.5	-0.9	0.6	0.7	-1.0	2.0	0.8	-2.3	-2.0	1.4
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	-0.7	-0.4	0.6	-0.3	-0.4	1.0	-0.6	0.8	1.0	0.4	0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.9	-0.5	-0.3	0.6	-0.7	-0.7	0.7	-0.0	0.4	-0.4	-0.4	0.9
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	6.0	1.5	1.5	-1.0	0.6	0.8	-1.3	2.0	0.1	-2.5	-2.0	1.2
Pavlov. Cond. response bias	0.7	0.9	2.2	1.2	0.9	-1.2	0.8	0.9	-1.5	1.0	-0.2	-1.2	-0.5	-0.2
Pavlov. Cond. lever latency	0.1	0.2	0.6	0.1	0.4	0.2	-0.0	0.0	0.4	0.5	0.5	-0.5	-0.8	0.8
Pavlov. Cond. magazine entry latency	0.7	1.0	2.2	1.2	1.1	-1.1	1.0	1.0	-1.5	1.1	0.6	-0.9	-0.6	-0.1
Pavlov. Cond. change in total contacts	0.2	0.4	1.0	0.6	0.6	-0.6	0.2	0.2	-0.7	0.8	-0.0	-1.0	-0.8	0.5
Pavlov. Cond. index score	0.1	0.1	0.4	0.3	0.2	-0.3	0.1	0.1	-0.6	0.3	-0.0	-0.6	-0.3	0.2
Pavlov. Cond. latency score	0.0	0.0	0.2	0.1	0.0	-0.1	-0.1	-0.1	-0.4	0.2	-0.2	-0.4	-0.2	0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.6	-0.2	-0.4	-0.1	-0.1	-0.1	-0.4	-0.6	-0.7	0.4	0.8	-0.7
Pavlov. Cond. magazine entry number	1.1	1.5	3.0	-1.5	-1.3	1.3	-1.1	-1.2	1.7	-1.4	-0.6	1.3	1.0	-0.1
Pavlov. Cond. intertrial magazine entries	0.5	1.0	2.5	-0.8	-0.5	1.2	-1.2	-1.1	1.3	0.0	-1.1	-0.8	-0.8	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.6	0.5	0.4	-0.4	0.2	0.2	-0.7	0.5	0.1	-0.7	-0.4	0.2
Pavlov. Cond. response bias	0.3	0.4	1.4	0.7	0.5	-0.8	0.6	0.6	-1.2	0.4	-0.1	-0.4	-0.0	-0.5
Time in closed arm before self-admin	0.4	0.7	1.4	0.8	1.2	-0.8	0.9	0.9	-0.3	1.1	0.9	-0.2	-1.0	0.5
Time in closed arm after self-admin	2.3	2.6	4.2	1.9	2.0	-1.4	1.5	1.6	-1.6	2.0	1.4	-1.4	-1.8	0.6
Time in open arm before self-admin	0.3	0.4	1.3	-0.3	-0.5	-0.3	0.1	-0.1	0.0	-0.8	-0.2	0.9	1.1	-1.1
Time in open arm after self-admin	0.6	0.7	2.0	-0.8	-0.7	0.3	-0.1	-0.5	1.1	-1.0	-0.3	1.4	1.1	-0.8
Bone: periosteal estimation	5.4	12.7	18.2	-4.3	-4.2	4.2	-4.2	-4.2	3.7	-3.6	-4.0	1.6	2.2	0.9
Bone: periosteal perimeter	4.1	8.2	13.1	-3.3	-3.2	3.4	-3.5	-3.4	3.1	-2.5	-3.6	0.8	1.2	1.3
Bone: post-yield work	2.6	4.5	7.7	-2.4	-2.7	2.8	-2.8	-2.4	1.6	-2.1	-2.4	0.4	1.3	0.6
Progressive ratio test 1 active lever presses	2.0	3.6	5.7	-2.3	-2.3	1.7	-1.7	-1.9	2.2	-2.4	-0.8	2.1	1.9	-0.5
Progressive ratio test 1 breakpoint	1.9	3.2	5.1	-2.2	-2.1	1.6	-1.6	-1.8	2.0	-2.3	-0.8	2.0	1.8	-0.4
Progressive ratio test 1 inactive lever presses	0.8	2.1	4.1	-1.8	-1.6	1.1	-1.1	-1.4	1.9	-1.8	-0.4	2.0	1.4	-0.4
Progressive ratio test 2 active lever presses	5.2	7.4	11.6	-3.4	-3.2	2.8	-2.7	-2.8	3.2	-3.3	-1.3	2.7	2.4	-0.2
Progressive ratio test 2 breakpoint	6.2	7.9	12.3	-3.5	-3.4	2.9	-2.8	-2.9	3.3	-3.4	-1.4	2.8	2.5	-0.3
Progressive ratio test 2 inactive lever presses	0.9	2.8	6.7	-1.9	-1.7	1.2	-1.1	-1.4	2.2	-2.1	-0.2	2.6	1.7	-0.6
Incentive Sensitization - Responses	1.7	4.7	7.3	-2.7	-2.5	2.3	-2.1	-2.3	2.7	-2.6	-1.2	2.2	1.9	-0.1
Incentive Sensitization - Breakpoint	2.3	5.2	8.1	-2.8	-2.7	2.4	-2.2	-2.4	2.8	-2.7	-1.3	2.3	1.9	-0.1
Sum of active levers in priming session hrs 5-6	0.9	0.9	2.2	1.1	1.1	-1.0	1.5	1.3	-0.7	0.6	0.7	0.3	-0.2	-1.0
Progressive ratio	0.2	0.5	1.9	0.2	0.2	0.2	-0.4	-0.1	-0.3	0.7	0.1	-1.4	-1.2	1.2
Food seeking constrained by brief footshock	1.8	2.3	5.0	-1.7	-1.9	1.9	-2.2	-2.0	1.2	-1.3	-1.3	-0.4	0.4	1.0
Seeking ratio, punishment vs. effort	0.1	0.2	0.6	-0.4	-0.6	0.3	-0.3	-0.3	0.2	-0.7	-0.4	0.4	0.8	-0.5
Retroperitoneal fat weight	0.0	0.2	0.8	-0.4	-0.4	0.4	-0.3	-0.4	0.2	-0.3	-0.9	0.2	0.4	0.0
Reaction time number correct	0.2	0.8	1.8	-1.1	-0.7	1.3	-1.0	-1.1	1.4	-0.5	-0.5	0.5	-0.0	1.0
Reaction time mean minus median	0.2	1.2	2.8	-1.0	-1.4	0.6	-0.7	-0.7	0.6	-1.6	0.0	1.4	1.7	-1.3
Reaction time mean minus median AUC	0.1	0.8	2.4	-0.4	-0.8	-0.2	0.1	-0.1	0.1	-1.2	0.7	1.3	1.5	-1.6
Reaction time num false alarms	0.6	1.0	3.2	-0.4	-0.2	1.2	-1.1	-0.9	0.7	0.4	-0.6	-1.2	-1.1	1.8
Reaction time num false alarms AUC	0.3	0.8	2.4	-0.2	-0.1	1.0	-0.9	-0.6	0.3	0.4	-0.7	-1.4	-1.0	1.6
Reaction time trials correct on left	0.2	0.8	1.8	-1.1	-0.7	1.3	-1.0	-1.1	1.4	-0.5	-0.5	0.5	-0.0	1.0
Reaction time trials on left	0.2	0.8	1.8	-1.1	-0.8	1.3	-1.1	-1.1	1.3	-0.5	-0.4	0.5	-0.0	1.0
Reaction time mean	0.6	1.2	2.6	1.0	0.6	-1.4	1.2	1.3	-1.6	0.2	1.0	-0.0	0.7	-1.6
Reaction time mean AUC	0.7	1.6	3.3	1.2	0.8	-1.6	1.5	1.6	-1.8	0.3	1.4	0.0	0.7	-1.8
Median of all reaction times	1.3	2.0	4.2	1.5	1.2	-1.8	1.7	1.8	-2.0	0.7	1.3	-0.3	0.3	-1.5
Reaction time omissions	0.0	0.1	0.2	0.0	-0.2	-0.1	-0.1	0.1	-0.4	-0.1	-0.2	-0.3	0.4	-0.3
Reaction time false alarm rate	0.3	0.4	1.7	0.1	0.0	0.5	-0.5	-0.2	-0.1	0.5	-0.4	-1.3	-0.8	1.0
Reaction time premature initiation rate	0.9	1.4	3.8	-1.3	-1.1	1.2	-1.4	-1.5	1.5	-0.7	-1.9	-0.1	0.1	1.0
Reaction time premature initiations	1.1	3.4	5.8	-2.1	-1.7	2.1	-2.3	-2.3	2.3	-1.2	-2.4	0.2	0.2	1.5
Std. dev. reaction times	0.3	0.8	3.3	-0.3	-0.8	-0.2	0.1	0.1	-0.5	-1.1	0.1	0.9	1.7	-1.8
Reaction time trials completed	0.2	0.8	1.8	-1.1	-0.8	1.3	-1.1	-1.1	1.3	-0.5	-0.4	0.5	-0.0	1.0
Reaction time trials AUC	0.1	0.5	1.2	-0.7	-0.4	1.0	-0.8	-0.9	1.1	-0.2	-0.3	0.3	-0.3	1.1
Run reversals in cocaine runway, females	0.4	0.4	1.1	0.3	0.4	-1.0	0.9	0.6	0.0	-0.0	-0.3	0.9	0.5	-1.0
Run reversals in cocaine runway, males	0.1	0.1	0.4	0.2	0.0	-0.1	-0.0	0.2	-0.6	0.2	0.3	-0.6	-0.1	0.1
Latency to leave start box in cocaine runway	0.3	0.4	0.9	-0.6	-0.6	1.0	-0.8	-0.7	0.8	-0.4	-0.2	-0.1	0.1	0.6
Latency to leave start box in cocaine runway, F	0.1	0.2	0.6	-0.1	-0.1	0.6	-0.4	-0.1	0.3	0.2	0.7	-0.4	-0.3	0.7
Latency to leave start box in cocaine runway, M	0.6	0.5	0.9	-0.9	-0.8	0.8	-0.7	-0.9	0.9	-0.7	-0.9	0.4	0.4	0.1
Std. dev. time between licks in bursts	0.9	1.7	4.1	1.4	1.0	-1.5	1.6	1.7	-2.0	0.5	1.0	0.1	0.3	-1.6
Total sessions with >9 infusions	0.4	0.4	1.5	-0.6	-0.6	0.2	-0.1	-0.3	0.5	-0.9	0.3	1.2	1.0	-0.7
Short access day 1 total inactive lever presses	0.6	1.2	4.8	-1.1	-0.8	0.4	-0.3	-0.7	1.4	-1.3	0.3	2.2	1.2	-0.8
Short access day 10 total inactive lever presses	0.2	1.0	1.9	1.1	1.3	-0.9	0.9	0.9	-0.6	1.4	0.9	-1.0	-1.3	0.6
Short access day 1 total infusions	0.1	0.3	1.3	-0.3	-0.4	0.0	0.1	-0.1	0.2	-0.7	0.1	1.1	0.7	-0.8
Short access day 10 total infusions	0.3	0.4	1.5	-0.3	-0.4	-0.2	0.2	0.0	0.3	-0.7	0.5	1.2	1.0	-1.0
Short access total infusions	0.9	1.3	2.9	-1.3	-1.2	0.9	-0.8	-1.0	1.4	-1.4	-0.4	1.7	1.2	-0.5
Short access day 1 locomotion	0.2	0.3	0.8	0.2	0.3	-0.6	0.7	0.4	0.2	-0.0	0.6	0.9	0.3	-0.7
Short access day 10 total locomotion	0.1	0.5	1.1	0.7	0.9	-1.0	0.9	0.7	-0.3	0.7	1.0	-0.1	-0.4	-0.2
Short access total locomotion	0.5	0.7	1.5	0.6	0.6	-1.2	1.1	0.9	-0.3	0.1	1.1	0.9	0.5	-1.2
One hour access (0.3 mA shock)	8.4	10.0	15.4	-3.9	-3.8	3.5	-3.4	-3.5	3.5	-3.7	-2.2	2.7	2.6	0.1
Compulsive drug intake	0.2	0.3	0.8	-0.6	-0.6	0.4	-0.8	-0.7	0.3	-0.3	-0.9	-0.1	0.2	0.5
One hour access (shock baseline)	1.7	4.5	7.0	-2.6	-2.6	2.3	-2.2	-2.3	2.5	-2.5	-1.3	1.9	1.8	-0.0
Social response proportion	0.3	0.4	2.3	-0.2	-0.1	0.1	0.3	0.1	0.7	-0.5	0.6	1.5	0.4	-0.5
Social responses	1.3	1.8	4.6	-1.4	-1.4	1.1	-0.8	-0.8	1.4	-1.8	-0.1	2.1	1.6	-0.9
Social time	0.4	0.6	1.1	0.9	0.8	-0.8	0.8	1.0	-0.9	0.6	1.0	-0.2	-0.3	-0.3
Soleus weight	1.2	3.6	5.6	-2.3	-2.3	1.8	-1.8	-2.0	1.7	-2.4	-1.4	2.0	1.8	-0.4
Bone: stiffness	2.6	4.6	9.0	-2.3	-2.4	2.9	-3.0	-2.6	2.1	-1.5	-2.4	-0.4	0.3	1.8
Tibialis anterior weight	0.8	2.8	11.8	-0.1	0.5	0.9	-1.2	-1.0	1.1	1.5	-0.4	-2.1	-2.7	3.4
Time to tail flick, vehicle, before self-admin	0.6	0.8	1.8	0.7	0.8	-1.3	1.4	0.9	-0.2	0.2	0.6	1.1	0.2	-1.1
Time to tail flick, vehicle, after self-admin	1.0	2.0	6.7	0.6	1.0	0.1	-0.4	-0.1	0.4	1.7	0.1	-2.3	-2.4	2.6
Time to tail flick, test, before self-admin	0.6	0.7	1.4	-1.1	-0.9	1.0	-1.1	-1.2	1.0	-0.6	-0.9	0.4	0.1	0.6
Time to tail flick, test, after self-admin	2.0	2.1	3.7	1.8	1.9	-1.7	1.8	1.6	-1.0	1.7	1.4	-0.8	-1.2	-0.0
Delta time to tail flick, vehicle, before/after SA	3.2	3.4	13.1	-0.5	-0.0	1.5	-1.8	-1.3	1.1	1.2	-0.8	-2.8	-2.4	3.6
Delta time to tail flick, test, before/after SA	0.9	1.1	1.7	1.3	1.3	-1.2	1.3	1.3	-0.8	1.1	0.9	-0.6	-0.7	-0.2
Tibia length	0.2	0.5	1.7	-0.7	-0.9	0.8	-0.8	-0.7	0.2	-0.8	-1.3	-0.1	0.6	-0.1
Ambulatory time before self-admin	0.4	1.2	1.9	1.4	1.4	-1.1	1.2	1.2	-1.0	1.3	0.8	-0.9	-0.9	-0.0
Ambulatory time after self-admin	0.2	0.4	1.9	-0.5	-0.0	0.0	0.2	-0.2	1.1	-0.4	-0.5	1.4	0.4	-0.3
Bone: tissue strength	0.4	0.4	1.3	-0.2	-0.5	-0.1	0.1	0.2	-0.4	-0.8	0.4	0.8	1.1	-1.2
Total heroin consumption	0.5	0.6	1.5	-0.9	-0.6	1.0	-0.9	-1.0	1.2	-0.4	-0.6	0.1	-0.2	0.9
Bone: trabecular number	4.4	8.3	12.4	-3.5	-3.4	2.8	-2.7	-3.0	3.2	-3.4	-2.3	3.0	2.6	-0.5
Bone: trabecular spacing	1.8	2.7	4.4	2.0	1.9	-1.4	1.3	1.6	-2.0	2.1	0.5	-2.1	-1.6	0.5
Bone: trabecular thickness	4.2	5.8	8.6	-2.9	-2.8	2.5	-2.5	-2.6	2.7	-2.6	-2.7	1.8	1.8	0.1
Bone: trabecular tissue density	0.7	1.1	3.0	-1.3	-0.9	1.2	-1.1	-1.2	1.7	-0.8	-1.2	0.5	0.1	0.8
Water consumed over 24 hours	0.9	1.7	4.3	1.0	1.4	-0.7	0.4	0.5	-0.3	1.8	1.3	-1.8	-2.1	1.7
Number of responses in last shaping day	1.7	2.2	5.5	-1.2	-1.6	0.7	-0.4	-0.6	0.3	-2.1	0.1	2.3	2.2	-2.0