Hub : Genes

Cox6b2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Cox6b2	0.06	0.05	6.1e-08	0.06	0.05	0.05	0.05	6.6e-09	3.3e-08	2.2e-08	1.6e-08
2	Brain	gene expression	Cox6b2	0.09	0.05	2.9e-08	0.05	0.07	0.07	0.07	2.3e-05	2.3e-07	2.0e-07	3.1e-07
3	Liver	gene expression	Cox6b2	0.02	0.02	5.1e-03	0.02	0.01	0.01	0.02	2.8e-03	6.9e-03	7.2e-03	5.6e-03
4	BLA	gene expression	Cox6b2	0.12	0.08	2.5e-05	0.05	0.07	0.05	0.05	1.1e-03	1.8e-04	1.2e-03	1.1e-03
5	PL	gene expression	Cox6b2	0.12	0.07	8.8e-13	0.1	0.11	0.1	0.1	1.6e-11	1.3e-11	4.9e-11	2.5e-11
6	IL	gene expression	Cox6b2	0.15	0.11	4.5e-03	0.05	0.05	0.06	0.03	2.8e-02	2.3e-02	1.3e-02	5.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.0	0.1	0.1	-0.3	-0.3	-0.3	0.3	0.2	-0.3
Area under the delay curve	0.3	0.5	0.8	0.7	0.6	0.7	-0.6	-0.6	0.9
BMI with tail	0.5	1.6	2.1	1.4	1.2	1.4	-1.2	-1.0	1.3
BMI without tail	0.1	0.3	0.5	-0.3	-0.5	-0.5	0.6	0.7	-0.7
Body weight	1.5	6.4	7.3	-2.5	-2.7	-2.3	2.6	2.7	-2.4
Weight adjusted by age	0.1	0.4	0.8	-0.9	-0.7	-0.7	0.6	0.4	-0.4
Bone surface	3.2	6.4	7.2	-2.7	-2.6	-2.5	2.5	2.4	-2.5
Bone volume	2.4	4.8	5.4	-2.3	-2.3	-2.1	2.1	2.0	-2.2
Breakpoint value in progressive ratio session	0.2	0.4	0.7	0.7	0.6	0.8	-0.7	-0.6	0.4
Number of licking bursts	0.0	0.1	0.1	0.3	0.3	0.3	-0.3	-0.3	0.1
Context. condit. distance diff. score	0.2	0.3	0.5	0.3	0.5	0.4	-0.6	-0.6	0.7
Locomotion velocity, session 1	1.1	1.2	2.5	0.5	1.2	0.4	-1.1	-1.6	1.3
Locomotion distance, session 1	0.9	1.1	2.2	-1.5	-0.9	-1.4	0.9	0.5	-0.9
Locomotion velocity, session 2	0.5	0.6	1.2	0.4	0.8	0.6	-0.8	-1.1	0.7
Locomotion distance, session 2	0.9	1.3	2.1	-1.4	-1.0	-1.5	1.1	0.8	-0.9
Locomotion velocity, session 3	0.1	0.1	0.2	0.1	0.3	0.3	-0.4	-0.4	0.2
Locomotion distance, session 3	0.0	0.1	0.2	-0.5	-0.1	-0.3	0.0	-0.1	-0.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	0.6	0.4	0.3	-0.3	-0.2	0.1
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.5	0.3	0.3	-0.2	-0.1	0.1
Locomotion velocity, session 7	0.0	0.0	0.1	-0.0	0.2	-0.1	-0.1	-0.3	-0.1
Locomotion distance, session 7	0.1	0.1	0.3	0.2	0.4	0.1	-0.4	-0.6	0.4
Stereotopy head waving bouts, day 7	0.3	0.3	0.7	-0.3	-0.5	-0.5	0.6	0.6	-0.9
Stereotopy head waving duration, day 7	0.3	0.4	0.7	-0.5	-0.6	-0.5	0.6	0.7	-0.8
Locomotion velocity, session 8	0.3	0.3	0.7	0.3	0.7	0.3	-0.6	-0.9	0.4
Locomotion distance, session 8	0.0	0.0	0.1	-0.2	0.1	-0.3	-0.1	-0.3	0.3
Degree of sensitization distance	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0	-0.0	0.1
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.2	-0.3	-0.2	0.3	0.4	-0.5
Conditioned locomotion	0.0	0.0	0.1	-0.2	0.1	0.1	-0.2	-0.4	0.1
Cocaine response after cond. corrected	0.5	0.7	1.6	1.0	0.6	1.3	-0.7	-0.4	0.7
Cocaine response after cond. not corrected	0.3	0.4	0.7	-0.5	-0.8	-0.3	0.7	0.8	-0.6
Cocaine response before conditioning	6.2	7.4	9.7	-2.9	-2.7	-3.1	2.7	2.4	-2.5
Saline control response	0.1	0.2	0.6	-0.4	0.2	0.3	-0.5	-0.8	0.1
Bone: connectivity density	0.0	0.0	0.1	0.0	0.0	0.3	-0.2	-0.2	0.2
Bone: cortical apparent density	0.1	0.1	0.3	-0.3	-0.0	0.0	-0.2	-0.4	0.5
Bone: cortical area	0.9	1.4	1.6	-1.3	-1.2	-1.3	1.2	1.1	-1.2
Bone: cortical porosity	0.3	0.4	0.6	0.8	0.6	0.8	-0.6	-0.4	-0.1
Bone: cortical porosity	0.1	0.1	0.4	0.3	0.1	0.3	-0.0	0.1	-0.7
Bone: cortical thickness	0.5	0.8	1.0	0.8	1.0	0.8	-0.9	-1.0	0.7
Bone: cortical thickness	0.0	0.0	0.1	-0.3	-0.1	-0.2	0.1	-0.0	0.1
Bone: cortical tissue density	0.1	0.1	0.3	-0.3	-0.0	0.0	-0.2	-0.4	0.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.3	0.3	0.5	-0.4	-0.4	0.1
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.9	1.1	1.0	1.4	-1.2	-1.0	1.1
Condit. Reinf. active responses	0.1	0.2	0.5	-0.4	-0.4	-0.3	0.3	0.3	-0.7
Condit. Reinf. inactive responses	2.4	3.1	3.9	-1.7	-1.6	-2.0	1.7	1.5	-1.9
Incentive salience index mean	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.2	0.2	-0.3
Condit. Reinf. lever presses	0.6	0.8	1.1	-1.0	-0.9	-1.0	0.9	0.8	-0.7
Condit. Reinf. active minus inactive responses	3.1	4.8	5.5	-2.2	-2.1	-2.3	2.2	2.0	-2.3
Condit. Reinf. active-inactive response ratio	4.7	7.5	8.1	-2.6	-2.7	-2.8	2.8	2.7	-2.8
Condit. Reinf. active responses	2.3	3.3	4.3	-1.9	-1.6	-2.1	1.7	1.5	-2.0
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	0.3	0.0	-0.3	-0.4	0.0
Condit. Reinf. lever presses	1.0	1.5	2.2	-0.7	-1.1	-1.0	1.3	1.4	-1.5
Condit. Reinf. lever reinforcers received	3.1	4.4	5.6	-2.2	-1.9	-2.4	2.0	1.7	-2.2
Conditioned reinforcement - actives	0.1	0.5	0.7	-0.7	-0.9	-0.6	0.7	0.8	-0.0
Conditioned reinforcement - inactives	0.9	2.5	3.4	-1.6	-1.6	-1.8	1.7	1.5	-1.0
Conditioned locomotion	0.2	0.2	0.3	-0.5	-0.6	-0.4	0.5	0.6	-0.2
Patch foraging indifference point 0 sec	0.4	1.1	1.6	0.6	1.0	0.9	-1.1	-1.2	1.3
Patch foraging indifference point AUC	0.3	0.8	1.2	1.1	0.9	0.9	-0.9	-0.8	0.8
Delay disc. indifference point, 0s delay	0.2	0.3	0.5	0.3	0.6	0.3	-0.5	-0.7	0.7
Delay disc. indifference point, 16s delay	0.1	0.2	0.5	0.7	0.3	0.6	-0.4	-0.1	0.2
Delay disc. indifference point, 2s delay	0.9	1.0	1.9	0.9	0.9	0.9	-0.9	-0.9	1.4
Delay disc. indifference point, 24s delay	0.2	0.4	0.6	0.8	0.5	0.7	-0.6	-0.4	0.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.2	-0.4	-0.3	0.3	0.4	-0.0
Delay disc. indifference point, 8s delay	0.1	0.2	0.4	0.4	0.4	0.3	-0.4	-0.4	0.6
Indifference point function ln k	2.0	6.1	7.9	-2.8	-2.3	-2.8	2.4	2.0	-2.4
Indifference point function log k	2.0	6.1	7.9	-2.8	-2.3	-2.8	2.4	2.0	-2.4
Patch foraging total patch changes 0 sec	0.4	1.0	1.5	0.6	1.0	0.9	-1.1	-1.2	1.2
Patch foraging total patch changes 12 sec	0.2	0.2	0.4	0.5	0.4	0.5	-0.5	-0.4	0.7
Patch foraging total patch changes 18 sec	0.4	0.9	1.4	0.7	0.8	1.0	-1.0	-1.0	1.2
Patch foraging total patch changes 24 sec	0.0	0.1	0.3	-0.2	-0.4	-0.2	0.4	0.6	-0.4
Patch foraging total patch changes 6 sec	0.9	1.5	1.9	1.2	1.2	1.1	-1.2	-1.1	1.4
Patch foraging time to switch 0 sec	0.3	1.0	2.3	1.5	0.6	1.5	-0.7	-0.1	0.8
Patch foraging water rate 0 sec	0.1	0.2	0.6	-0.7	-0.2	-0.8	0.3	-0.0	-0.2
Patch foraging water rate 12 sec	0.4	1.5	2.8	-1.7	-1.1	-1.7	1.0	0.6	-1.0
Patch foraging water rate 18 sec	0.2	0.5	1.0	-0.9	-0.5	-1.0	0.6	0.3	-0.6
Patch foraging water rate 24 sec	0.4	0.6	1.2	-1.1	-0.7	-1.0	0.7	0.4	-0.7
Patch foraging water rate 6 sec	5.9	8.6	9.8	-3.1	-2.9	-3.0	2.9	2.7	-3.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.5	-0.1	0.4	0.2	-0.5	-0.7	0.4
Distance traveled before self-admin	0.2	0.5	1.1	-1.1	-0.5	-1.0	0.5	0.0	-0.5
Distance traveled after self-admin	0.7	1.2	2.2	0.8	1.2	0.9	-1.2	-1.5	0.7
Extensor digitorum longus weight	0.4	1.5	1.9	-1.2	-1.2	-1.1	1.3	1.4	-1.2
Bone: elastic displacement	0.7	0.8	1.4	1.2	1.1	0.7	-0.9	-1.0	0.5
Bone: elastic work	0.2	0.2	0.6	-0.4	-0.4	-0.8	0.5	0.4	-0.3
Bone: endosteal estimation	3.2	7.8	8.5	-2.8	-2.9	-2.9	2.9	2.9	-2.3
Bone: endosteal perimeter	1.8	4.5	5.0	-2.2	-2.2	-2.2	2.2	2.1	-1.8
Epididymis fat weight	0.1	0.4	1.1	-0.0	-0.7	-0.3	0.7	1.0	-0.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.3	0.4	-0.0	-0.3	-0.3	0.5
Delta time in open arm before/after self-admin	1.1	1.3	2.0	-1.3	-1.1	-1.1	1.0	0.8	-1.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.1	0.2	0.0	-0.3	-0.5	0.5
Delay discount exponential model param	0.2	0.3	0.6	-0.6	-0.4	-0.5	0.5	0.4	-0.8
Extinction: sum of active levers before priming	0.1	0.2	0.4	0.5	0.6	0.4	-0.5	-0.6	0.2
Active lever presses in extinction session 6	0.2	0.2	0.4	-0.1	-0.4	0.1	0.4	0.7	-0.5
Bone: final force	2.2	3.6	4.3	-2.0	-2.0	-2.1	2.0	1.9	-1.5
Bone: final moment	2.7	4.3	5.3	-2.3	-2.1	-2.3	2.1	2.0	-1.6
Food consumed during 24 hour testing period	1.1	2.2	2.7	-1.6	-1.6	-1.6	1.5	1.4	-1.3
Glucose	2.3	3.6	4.0	1.7	1.9	1.7	-1.9	-2.0	2.0
Heart weight	1.9	3.1	3.4	-1.7	-1.8	-1.7	1.8	1.8	-1.8
Delay discount hyperbolic model param	0.4	0.5	0.9	-0.7	-0.6	-0.6	0.6	0.6	-1.0
Intermittent access intake day 1-15 change	0.2	1.0	1.1	-1.0	-1.0	-0.8	1.1	1.0	-0.9
Intermittent access intake escalation	0.3	1.8	2.0	-1.3	-1.4	-1.1	1.4	1.4	-1.3
Intermittent access intake escalation 2	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.1	-0.0	-0.2
Intermitt. access day 1 inactive lever presses	0.2	2.5	3.0	-1.4	-1.6	-1.5	1.7	1.7	-1.6
Intermitt. access day 15 inactive lever presses	0.9	4.8	5.4	-1.9	-2.1	-2.3	2.2	2.3	-2.3
Intermitt. access escalation Index	0.2	0.7	1.1	0.8	0.7	1.0	-0.7	-0.7	1.0
Intermittent access day 1 total infusions	0.3	0.8	1.1	-0.9	-1.0	-0.8	1.0	1.0	-0.4
Intermittent access day 15 total infusions	0.7	1.7	2.3	-1.3	-1.5	-1.0	1.4	1.5	-0.9
Intermittent access terminal intake (last 3 days)	0.7	1.3	1.7	-1.2	-1.3	-0.9	1.3	1.3	-0.7
Intermittent access total infusions	1.6	2.0	2.5	-1.5	-1.6	-1.3	1.5	1.6	-0.8
Intermittent access day 1 locomotion	0.8	1.4	1.9	-1.3	-1.4	-1.1	1.3	1.3	-0.6
Intermittent access day 15 total locomotion	0.2	0.9	1.6	-1.3	-1.1	-0.9	1.1	0.9	-0.4
Intermittent access total locomotion	2.8	3.3	4.4	-2.1	-2.1	-1.7	2.0	1.8	-1.2
Intermittent access standard deviation	0.1	0.4	0.7	0.4	0.5	0.8	-0.6	-0.6	0.8
Left kidney weight	3.4	27.0	28.5	-5.3	-5.3	-5.3	5.2	5.0	-5.0
Right kidney weight	4.1	28.4	29.7	-5.2	-5.4	-5.4	5.4	5.3	-5.2
Cocaine induced anxiety	0.5	1.4	2.2	-1.2	-1.2	-1.1	1.1	1.0	-1.5
Post-drug Anxiety	1.0	1.1	2.4	-0.8	-1.0	-0.8	1.0	1.1	-1.5
Baseline Anxiety	0.4	0.6	0.9	0.9	0.8	0.9	-0.7	-0.6	0.8
Tail length	2.7	14.3	15.4	-3.9	-3.8	-3.8	3.8	3.6	-3.8
Length with tail	3.8	16.7	18.4	-4.2	-4.3	-3.9	4.1	4.1	-4.0
Length without tail	1.4	7.5	9.3	-2.6	-3.1	-2.3	2.8	3.0	-2.6
Times rat made contact with spout	0.0	0.0	0.1	0.3	0.0	0.2	-0.1	0.1	0.1
Lifetime Intake	1.1	1.3	1.7	-1.2	-1.3	-1.1	1.3	1.3	-0.6
Liver weight, left	1.2	2.1	2.4	-1.4	-1.5	-1.5	1.4	1.4	-1.3
Liver weight, right	0.0	0.0	0.0	0.0	-0.1	-0.2	0.1	0.1	0.2
Locomotor activity	0.0	0.1	0.1	0.3	0.1	0.2	-0.2	-0.1	0.3
Locomotor testing distance	0.1	0.2	0.4	-0.3	-0.6	-0.4	0.5	0.7	-0.4
Locomotor testing rearing	0.3	1.1	1.6	-1.1	-1.3	-1.0	1.0	1.1	-0.8
Locomotion in novel chamber	1.4	1.9	2.8	0.8	1.1	1.7	-1.4	-1.4	1.6
Locomotion in novel chamber post-restriction	0.3	0.8	1.7	0.8	0.7	0.9	-0.8	-0.7	1.3
Fecal boli incidents, locomotor time 1	0.1	0.3	0.4	-0.6	-0.5	-0.6	0.5	0.4	-0.2
Change in fecal boli incidents, locomotor task	3.4	3.6	4.0	1.8	1.9	1.9	-1.9	-1.8	2.0
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.0	0.1	0.1	-0.0	0.0	0.0
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.5	0.1	-0.3	-0.1	-0.5	0.2
Total resting periods, locomotor time 1	0.2	0.2	0.4	-0.0	0.4	0.1	-0.4	-0.7	0.6
Rest time, locomotor task time 1	1.0	1.7	2.2	-1.5	-1.3	-1.4	1.3	1.3	-0.9
Distance moved, locomotor task time 1	0.6	1.8	2.3	1.5	1.4	1.4	-1.4	-1.3	1.0
Vertical activity count, locomotor time 1	0.7	5.1	6.0	2.3	2.3	2.2	-2.3	-2.4	2.1
Time >=10cm from walls, locomotor time 2	0.2	0.6	0.8	0.8	0.9	0.9	-0.8	-0.7	0.6
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.2	-0.1	-0.2	0.1	0.1	0.0
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.2	-0.1	-0.2	0.1	0.1	0.1
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.0	0.2	-0.0	-0.2	-0.3	0.4
Distance moved, locomotor task time 2	0.1	0.2	0.2	0.5	0.5	0.5	-0.4	-0.4	0.1
Vertical activity count, locomotor time 2	0.2	0.4	0.5	0.6	0.6	0.6	-0.6	-0.6	0.7
Light reinforcement 1	0.1	0.6	1.3	0.1	0.7	0.6	-0.8	-1.1	0.7
Light reinforcement 2	1.2	2.7	3.2	1.4	1.6	1.7	-1.7	-1.8	1.6
Bone: marrow area	3.2	7.9	8.6	-2.8	-2.9	-2.9	2.9	2.9	-2.4
Bone: maximum diameter	1.4	2.8	3.2	-1.6	-1.7	-1.6	1.7	1.8	-1.5
Bone: maximum force	3.2	6.3	7.0	-2.6	-2.6	-2.6	2.6	2.5	-2.1
Bone: maximum moment	3.6	6.8	7.8	-2.8	-2.7	-2.8	2.7	2.6	-2.1
Mean time between licks in bursts	0.2	1.4	1.9	1.1	1.4	1.0	-1.2	-1.3	1.2
Mean num. licks in bursts	0.1	0.2	0.4	-0.4	-0.6	-0.4	0.5	0.6	-0.2
Cd content in liver	2.1	2.3	3.1	-1.8	-1.5	-1.6	1.5	1.3	-1.4
Co content in liver	0.3	0.3	0.8	-0.9	-0.4	-0.7	0.4	0.1	-0.4
Cu content in liver	1.2	1.5	2.0	-1.4	-1.3	-1.0	1.1	1.1	-1.3
Fe content in liver	0.4	0.5	0.6	-0.8	-0.7	-0.6	0.6	0.6	-0.7
K content in liver	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.0	-0.0	-0.3
Mg content in liver	0.0	0.0	0.1	-0.0	-0.2	0.3	0.0	0.2	-0.3
Mn content in liver	0.1	0.1	0.4	-0.1	-0.3	0.1	0.2	0.3	-0.7
Na content in liver	2.8	3.1	4.1	1.7	1.8	2.0	-1.9	-1.8	1.3
Rb content in liver	3.6	4.2	5.8	-1.9	-2.1	-1.8	2.0	2.0	-2.4
Se content in liver	1.3	1.5	2.3	1.4	1.1	1.5	-1.2	-1.0	1.1
Sr content in liver	8.8	7.6	8.6	2.5	2.8	2.6	-2.8	-2.9	2.8
Zn content in liver	0.1	0.1	0.4	0.3	0.1	0.6	-0.2	0.1	0.2
Bone: minimum diameter	3.4	6.5	7.2	-2.7	-2.6	-2.7	2.5	2.4	-2.4
Time in familiar zone, hab. session 1	1.8	2.0	3.6	-1.9	-1.5	-1.8	1.3	1.0	-0.6
Time in novel zone, hab. session 1	2.1	2.4	3.4	1.8	1.7	1.8	-1.5	-1.4	0.8
Total zone transitions, hab. session 1	0.1	0.2	0.5	-0.7	-0.0	-0.5	0.0	-0.4	-0.1
Total locomotion distance, hab. session 1	0.1	0.1	0.4	-0.2	0.3	-0.2	-0.3	-0.6	0.3
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.2	0.2	-0.1	-0.2	-0.5	0.2
Time in familiar zone, hab. session 2	4.1	4.6	5.4	-2.1	-2.3	-2.0	2.2	2.3	-1.9
Time in novel zone, hab. session 2	2.4	2.7	3.2	1.8	1.8	1.6	-1.7	-1.7	1.2
Total zone transitions, hab. session 2	1.2	1.6	2.5	-1.6	-1.2	-1.5	1.1	0.8	-1.1
Total locomotion distance, hab. session 2	0.1	0.2	0.4	0.0	0.4	0.0	-0.4	-0.6	0.5
Locomotion velocity, hab. session 2	0.2	0.3	0.7	0.2	0.6	0.2	-0.6	-0.8	0.7
Novel to familiar place preference ratio	0.0	0.1	0.1	-0.2	-0.3	-0.2	0.2	0.3	-0.3
Novelty place preference	0.1	0.2	0.2	-0.4	-0.4	-0.4	0.4	0.4	-0.4
Time in novel zone, NPP test	0.2	0.3	0.3	-0.5	-0.6	-0.5	0.5	0.5	-0.4
Total zone transitions, NPP test	0.1	0.1	0.2	-0.5	-0.2	-0.5	0.2	-0.0	0.1
Total locomotion distance, NPP test	0.2	0.3	0.4	-0.5	-0.5	-0.6	0.5	0.4	-0.4
Locomotion velocity, NPP test	0.1	0.2	0.4	-0.5	-0.4	-0.6	0.4	0.3	-0.4
Intraocular pressure	0.0	0.1	0.1	0.2	0.3	0.3	-0.3	-0.4	0.0
Delta distance traveled before/after self-admin	1.8	2.0	2.5	1.5	1.4	1.6	-1.5	-1.3	1.1
Delta ambulatory time before/after self-admin	0.9	1.6	1.8	1.4	1.3	1.3	-1.3	-1.2	1.1
Parametrial fat weight	1.7	4.0	5.0	2.2	1.9	2.1	-1.9	-1.7	2.0
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.3	0.4	0.4	-0.4	-0.5	0.1
Pavlov. Cond. magazine entry latency	0.5	0.6	1.1	1.1	0.8	0.9	-0.7	-0.5	0.7
Pavlov. Cond. change in total contacts	0.3	0.3	0.5	0.4	0.5	0.6	-0.6	-0.5	0.7
Pavlov. Cond. index score	0.3	0.3	0.5	0.6	0.5	0.6	-0.5	-0.4	0.7
Pavlov. Cond. latency score	0.2	0.2	0.5	0.5	0.4	0.4	-0.4	-0.3	0.7
Pavlov. Cond. lever contacts	0.2	0.3	0.5	-0.4	-0.6	-0.5	0.6	0.7	-0.3
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	-0.5	-0.4	-0.5	0.3	0.2	-0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.2	0.2	0.8	0.4	-0.8	-1.1	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.5	0.6	0.5	0.6	-0.5	-0.4	0.7
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	-0.2	0.0	0.2	0.4	-0.1
Pavlov. Cond. lever latency	0.4	0.5	1.1	-1.1	-0.8	-0.7	0.6	0.6	-0.1
Pavlov. Cond. magazine entry latency	0.6	0.8	1.7	1.3	0.9	0.9	-0.8	-0.7	0.5
Pavlov. Cond. change in total contacts	0.0	0.1	0.6	0.0	-0.0	-0.2	0.2	0.1	-0.8
Pavlov. Cond. index score	0.1	0.2	0.5	0.7	0.4	0.3	-0.2	-0.1	-0.4
Pavlov. Cond. latency score	0.3	0.5	1.2	1.1	0.8	0.7	-0.6	-0.5	-0.0
Pavlov. Cond. lever contacts	0.1	0.2	0.6	0.7	0.5	0.4	-0.2	-0.2	-0.3
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	-1.0	-0.8	-0.8	0.7	0.6	-0.4
Pavlov. Cond. intertrial magazine entries	2.1	4.7	5.9	-2.4	-2.2	-2.2	2.1	1.9	-2.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.7	0.9	0.6	0.4	-0.3	-0.3	-0.2
Pavlov. Cond. response bias	0.1	0.2	0.7	0.2	-0.1	-0.3	0.4	0.4	-0.9
Time in closed arm before self-admin	0.7	1.1	1.4	-1.2	-1.2	-0.9	1.0	1.0	-1.2
Time in closed arm after self-admin	0.2	0.2	0.3	-0.4	-0.6	-0.5	0.5	0.6	-0.4
Time in open arm before self-admin	2.1	2.6	3.3	1.7	1.7	1.4	-1.6	-1.4	1.8
Time in open arm after self-admin	0.4	0.4	0.5	0.6	0.7	0.6	-0.6	-0.7	0.5
Bone: periosteal estimation	2.3	5.6	6.0	-2.4	-2.4	-2.4	2.4	2.4	-2.1
Bone: periosteal perimeter	1.7	3.4	3.8	-1.9	-1.8	-2.0	1.8	1.8	-1.7
Bone: post-yield work	4.0	6.9	7.7	-2.7	-2.8	-2.4	2.6	2.7	-2.5
Progressive ratio test 1 active lever presses	0.2	0.4	0.6	-0.8	-0.6	-0.8	0.6	0.4	-0.1
Progressive ratio test 1 breakpoint	0.2	0.4	0.6	-0.8	-0.6	-0.8	0.6	0.4	-0.1
Progressive ratio test 1 inactive lever presses	1.2	3.2	4.3	-1.8	-1.8	-2.1	1.9	1.7	-1.4
Progressive ratio test 2 active lever presses	0.7	0.9	1.4	-0.9	-1.1	-0.8	1.1	1.2	-0.6
Progressive ratio test 2 breakpoint	0.9	1.2	1.7	-1.0	-1.2	-0.9	1.2	1.3	-0.8
Progressive ratio test 2 inactive lever presses	1.4	4.4	4.8	-2.2	-2.2	-2.1	2.2	2.1	-1.7
Incentive Sensitization - Responses	1.1	3.0	3.9	-1.6	-1.9	-1.3	1.8	2.0	-1.7
Incentive Sensitization - Breakpoint	1.0	2.3	3.1	-1.3	-1.7	-1.1	1.6	1.8	-1.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.2	0.3	0.3	-0.3	-0.5	0.0
Progressive ratio	0.0	0.0	0.1	0.1	0.3	-0.1	-0.2	-0.4	-0.1
Food seeking constrained by brief footshock	1.1	1.4	3.6	0.4	1.4	0.1	-1.2	-1.9	1.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.4	-0.7	-0.4	-0.6	0.4	0.2	-0.1
Retroperitoneal fat weight	3.1	13.7	19.0	4.4	3.6	4.1	-3.5	-2.9	3.7
Reaction time number correct	0.1	0.4	0.4	0.6	0.6	0.4	-0.6	-0.6	0.7
Reaction time mean minus median	0.0	0.0	0.0	-0.1	-0.2	0.0	0.0	0.0	-0.1
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.1	-0.2	0.0	0.0	0.1	-0.0
Reaction time num false alarms	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.0	-0.1	-0.1
Reaction time num false alarms AUC	0.2	0.4	0.7	0.2	0.6	0.7	-0.7	-0.8	0.6
Reaction time trials correct on left	0.1	0.4	0.4	0.6	0.6	0.4	-0.6	-0.6	0.7
Reaction time trials on left	0.1	0.4	0.4	0.6	0.6	0.4	-0.6	-0.6	0.7
Reaction time mean	0.7	1.5	2.1	-1.2	-1.3	-1.1	1.2	1.2	-1.4
Reaction time mean AUC	0.3	0.8	1.1	-0.8	-1.0	-0.7	0.9	1.0	-1.0
Median of all reaction times	1.0	1.6	2.3	-1.1	-1.2	-1.1	1.2	1.3	-1.5
Reaction time omissions	0.1	0.2	0.4	-0.0	0.2	0.4	-0.5	-0.7	0.3
Reaction time false alarm rate	0.1	0.1	0.2	-0.1	0.2	0.4	-0.3	-0.5	0.2
Reaction time premature initiation rate	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.3	0.4	-0.2
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.0	0.1	-0.0	0.0	0.2
Std. dev. reaction times	0.3	1.0	1.3	-1.0	-1.1	-0.8	1.0	1.0	-1.1
Reaction time trials completed	0.1	0.4	0.4	0.6	0.6	0.4	-0.6	-0.6	0.7
Reaction time trials AUC	0.1	0.2	0.3	0.5	0.5	0.4	-0.4	-0.4	0.6
Run reversals in cocaine runway, females	0.6	0.7	0.8	-0.7	-0.8	-0.8	0.8	0.9	-0.9
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.1	-0.1	0.0	0.2	0.2	0.0
Latency to leave start box in cocaine runway	0.5	0.6	0.7	-0.8	-0.7	-0.8	0.8	0.8	-0.9
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	-0.3	-0.2	-0.3	0.3	0.3	-0.3
Latency to leave start box in cocaine runway, M	1.6	1.6	1.7	-1.3	-1.3	-1.1	1.3	1.2	-1.3
Std. dev. time between licks in bursts	0.5	0.9	1.9	0.6	1.2	0.5	-1.0	-1.4	0.7
Total sessions with >9 infusions	0.6	0.8	1.2	-1.1	-1.0	-0.9	0.9	0.8	-0.4
Short access day 1 total inactive lever presses	0.7	1.5	2.0	-1.1	-1.3	-1.0	1.3	1.4	-1.0
Short access day 10 total inactive lever presses	0.0	0.3	0.3	-0.5	-0.5	-0.4	0.6	0.6	-0.5
Short access day 1 total infusions	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.0	-0.0	0.4
Short access day 10 total infusions	0.1	0.1	0.4	0.2	0.2	0.1	-0.2	-0.2	0.6
Short access total infusions	0.1	0.2	0.7	0.3	0.2	0.2	-0.2	-0.2	0.8
Short access day 1 locomotion	0.3	0.6	0.8	-0.8	-0.9	-0.7	0.8	0.8	-0.2
Short access day 10 total locomotion	0.1	0.3	0.6	-0.8	-0.5	-0.7	0.5	0.2	-0.0
Short access total locomotion	0.1	0.1	0.6	-0.4	-0.1	-0.2	-0.0	-0.3	0.7
One hour access (0.3 mA shock)	4.4	5.3	6.1	-2.4	-2.5	-2.1	2.4	2.3	-2.0
Compulsive drug intake	1.6	2.4	3.3	-1.5	-1.6	-1.3	1.6	1.5	-1.8
One hour access (shock baseline)	0.3	0.7	1.1	-0.7	-0.9	-0.8	0.9	1.0	-0.4
Social response proportion	1.3	1.7	2.2	-1.2	-1.3	-1.1	1.3	1.4	-1.5
Social responses	3.4	4.5	5.4	-2.2	-2.1	-2.0	2.1	2.0	-2.3
Social time	1.9	2.9	4.5	-2.0	-1.5	-2.1	1.6	1.2	-1.6
Soleus weight	0.1	0.2	0.5	-0.7	-0.6	-0.3	0.4	0.5	-0.2
Bone: stiffness	2.8	5.0	5.5	-2.3	-2.3	-2.3	2.3	2.2	-2.0
Tibialis anterior weight	0.4	1.5	2.5	1.4	1.1	1.4	-1.1	-0.7	1.6
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.3	-0.5	-0.3	-0.5	0.4	0.2	-0.4
Time to tail flick, vehicle, after self-admin	0.3	0.7	1.0	-0.8	-0.9	-0.6	0.9	1.0	-0.8
Time to tail flick, test, before self-admin	0.7	0.8	1.7	0.4	0.7	0.7	-0.8	-1.1	1.3
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.5	0.3	0.3	-0.3	-0.2	0.1
Delta time to tail flick, vehicle, before/after SA	0.0	0.1	0.1	-0.0	-0.2	0.3	0.2	0.4	0.2
Delta time to tail flick, test, before/after SA	0.5	0.6	1.3	-0.3	-0.6	-0.7	0.7	0.8	-1.1
Tibia length	4.3	11.9	12.5	-3.4	-3.5	-3.5	3.5	3.5	-3.4
Ambulatory time before self-admin	0.2	0.6	1.2	-1.1	-0.6	-1.0	0.6	0.2	-0.8
Ambulatory time after self-admin	0.2	0.2	0.8	0.1	0.5	0.2	-0.6	-0.9	0.0
Bone: tissue strength	0.1	0.2	0.6	-0.4	-0.0	-0.3	-0.1	-0.3	0.7
Total heroin consumption	0.1	0.1	0.1	0.3	0.4	0.3	-0.3	-0.3	0.0
Bone: trabecular number	0.2	0.3	0.4	0.5	0.5	0.5	-0.6	-0.6	0.7
Bone: trabecular spacing	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1	0.2	0.1
Bone: trabecular thickness	0.0	0.0	0.0	-0.2	-0.2	-0.0	0.1	0.1	-0.1
Bone: trabecular tissue density	0.3	0.4	0.9	0.9	0.5	0.9	-0.6	-0.4	0.4
Water consumed over 24 hours	0.4	0.7	1.1	-1.0	-0.9	-1.1	0.8	0.6	-0.5
Number of responses in last shaping day	0.0	0.1	0.1	-0.1	-0.3	-0.3	0.3	0.3	0.1