Cox6b1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	alternative polyA	NM_001145273.1	0.13	0.11	3.3e-03	0.14	0.1	0.12	0.13	1.4e-04	1.1e-03	4.7e-04	2.7e-04
2	Adipose	mRNA stability	Cox6b1	0.03	0.02	4.2e-04	0.03	0.02	0.02	0.02	7.9e-04	1.5e-03	3.0e-03	1.7e-03
3	Brain	gene expression	Cox6b1	0.17	0.12	5.7e-04	0.01	0.03	0.03	0.01	6.9e-02	1.8e-03	1.4e-03	5.0e-02
4	NAcc	isoform ratio	XM_063274412.1	0.03	0.02	3.5e-03	0.01	0.01	0.01	0.01	8.8e-03	2.4e-02	6.6e-03	3.7e-02
5	PL	isoform ratio	XM_063274412.1	0.06	0.04	3.4e-04	0.02	0.01	0.02	0.01	2.1e-03	9.6e-03	4.9e-03	1.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.6	1.0	1.7	1.3	-1.3	1.2	-0.1	0.2
Area under the delay curve	0.7	0.8	1.7	0.8	-0.5	0.3	-1.3	-1.2
BMI with tail	0.1	0.3	0.8	0.2	0.4	-0.4	-0.9	-0.5
BMI without tail	0.4	1.1	1.6	1.2	-0.7	0.7	-1.3	-1.1
Body weight	2.8	12.3	22.0	4.7	-4.1	3.8	-1.9	-2.1
Weight adjusted by age	0.2	0.2	0.5	0.7	-0.5	0.6	-0.2	-0.3
Bone surface	1.6	2.8	4.2	1.7	-1.9	2.1	-1.3	-1.3
Bone volume	1.6	2.9	4.5	2.0	-2.0	2.1	-1.2	-1.0
Breakpoint value in progressive ratio session	1.0	1.2	1.5	1.2	-1.2	0.8	-1.1	-1.2
Number of licking bursts	1.1	1.9	3.1	-1.8	1.8	-1.7	-0.3	-0.1
Context. condit. distance diff. score	0.4	0.5	1.2	0.3	-0.2	-0.3	-0.9	-1.1
Locomotion velocity, session 1	0.2	0.2	0.8	-0.1	0.3	-0.3	0.5	0.9
Locomotion distance, session 1	1.8	2.2	4.7	1.5	-1.0	1.3	-2.2	-1.2
Locomotion velocity, session 2	0.5	0.6	1.2	-0.9	1.1	-0.1	0.0	0.9
Locomotion distance, session 2	0.9	1.2	4.6	-0.4	1.1	0.3	-2.2	-0.4
Locomotion velocity, session 3	0.1	0.2	0.4	-0.4	0.3	0.4	-0.6	0.2
Locomotion distance, session 3	5.2	5.6	10.6	1.8	-1.7	2.2	-3.3	-2.6
Stereotopy head waving bouts, day 3	2.2	2.6	5.0	-1.2	1.1	-1.0	2.2	2.1
Stereotopy head waving duration, day 3	3.4	4.0	6.9	-1.4	1.5	-1.7	2.6	2.5
Locomotion velocity, session 7	1.3	1.4	2.9	0.9	-0.9	1.0	-1.7	-1.3
Locomotion distance, session 7	0.8	1.0	2.4	0.4	-0.9	1.6	-1.1	-0.6
Stereotopy head waving bouts, day 7	1.3	1.5	3.4	-1.8	1.3	-1.6	0.1	-0.1
Stereotopy head waving duration, day 7	1.9	2.2	4.4	-1.6	1.7	-2.1	0.9	0.7
Locomotion velocity, session 8	1.6	2.0	3.4	-1.9	1.7	-1.7	-0.6	0.1
Locomotion distance, session 8	1.0	1.4	4.8	-0.4	0.5	0.1	-2.2	-1.4
Degree of sensitization distance	1.2	1.3	3.6	-1.0	0.4	-0.6	1.9	1.2
Degree of sensitization stereotypy	1.1	1.2	2.4	-1.5	1.0	-1.4	-0.4	-0.7
Conditioned locomotion	0.6	0.7	1.9	-0.6	1.0	-1.4	0.1	0.1
Cocaine response after cond. corrected	1.1	1.3	3.0	-0.2	0.5	-1.1	1.7	1.4
Cocaine response after cond. not corrected	1.4	1.7	5.0	-0.4	0.4	-0.7	2.2	1.6
Cocaine response before conditioning	0.8	1.0	3.1	0.3	-1.2	1.8	-0.1	-0.6
Saline control response	0.2	0.3	0.4	-0.4	0.4	-0.4	0.7	0.7
Bone: connectivity density	0.2	0.3	0.7	0.6	-0.5	0.8	-0.5	0.0
Bone: cortical apparent density	0.4	0.6	1.6	-0.5	1.2	-0.8	-0.2	0.5
Bone: cortical area	1.4	2.1	3.8	1.7	-1.8	1.9	-0.5	-0.7
Bone: cortical porosity	1.1	1.2	2.2	-1.5	1.3	-1.0	-0.8	-0.6
Bone: cortical porosity	1.5	1.6	2.8	-1.7	1.5	-1.2	-0.9	-0.7
Bone: cortical thickness	0.6	1.0	1.8	1.3	-1.1	1.3	0.0	0.1
Bone: cortical thickness	0.2	0.2	0.6	-0.1	0.6	-0.1	0.5	0.8
Bone: cortical tissue density	0.5	0.7	1.8	-0.6	1.4	-0.9	-0.3	0.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.1	0.6	-0.8	-0.2	0.2
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.9	-0.1	0.7	-0.9	1.0	1.4
Condit. Reinf. active responses	1.2	1.5	3.7	-0.9	1.7	-1.9	-0.4	0.2
Condit. Reinf. inactive responses	1.3	1.6	2.4	-1.0	1.6	-1.5	-1.3	-0.6
Incentive salience index mean	0.2	0.3	0.6	-0.1	0.7	-0.8	-0.6	-0.1
Condit. Reinf. lever presses	0.2	0.3	0.8	0.0	0.4	-0.6	-0.9	-0.6
Condit. Reinf. active minus inactive responses	0.6	0.8	1.4	1.1	-0.8	1.2	-0.7	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.0	0.2	-0.4	0.1	0.4
Condit. Reinf. active responses	1.8	2.5	4.2	1.4	-1.7	2.1	-1.4	-1.2
Condit. Reinf. inactive responses	2.5	3.2	4.3	1.1	-1.9	2.0	-1.7	-2.1
Condit. Reinf. lever presses	4.0	5.6	9.4	2.6	-2.8	3.1	-1.2	-1.5
Condit. Reinf. lever reinforcers received	2.4	3.4	5.1	1.6	-1.9	2.3	-1.8	-1.5
Conditioned reinforcement - actives	0.4	0.6	1.3	-1.1	0.8	-0.4	0.7	0.8
Conditioned reinforcement - inactives	0.9	1.4	4.0	0.4	0.1	-0.2	-2.0	-1.6
Conditioned locomotion	1.6	2.1	3.4	-1.7	1.8	-1.8	0.6	0.9
Patch foraging indifference point 0 sec	0.1	0.1	0.3	-0.4	-0.0	-0.5	0.4	-0.1
Patch foraging indifference point AUC	0.5	0.7	1.1	-0.9	0.9	-1.0	0.5	0.8
Delay disc. indifference point, 0s delay	2.2	2.4	5.3	1.4	-0.6	-0.2	-2.3	-2.1
Delay disc. indifference point, 16s delay	0.8	0.9	1.8	0.7	-0.3	0.2	-1.3	-1.4
Delay disc. indifference point, 2s delay	2.5	2.8	4.4	1.9	-1.3	1.2	-2.1	-1.7
Delay disc. indifference point, 24s delay	1.3	1.5	2.4	1.6	-1.2	0.6	-1.2	-1.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.9	-0.2	0.2	0.2	-0.9	-0.8
Delay disc. indifference point, 8s delay	0.1	0.2	0.3	0.1	-0.4	0.5	-0.4	-0.4
Indifference point function ln k	0.5	0.9	1.9	1.1	-0.7	1.4	-0.9	-0.3
Indifference point function log k	0.5	0.9	1.9	1.1	-0.7	1.4	-0.9	-0.3
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.2	-0.1	-0.3	0.2	-0.2
Patch foraging total patch changes 12 sec	0.5	0.6	1.0	-0.8	0.5	-0.6	1.0	0.9
Patch foraging total patch changes 18 sec	0.3	0.4	1.2	-1.1	0.1	-0.8	0.2	-0.3
Patch foraging total patch changes 24 sec	0.4	0.7	1.8	0.4	-1.1	0.2	-0.6	-1.4
Patch foraging total patch changes 6 sec	0.3	0.4	0.7	-0.8	0.3	-0.5	0.9	0.5
Patch foraging time to switch 0 sec	1.1	2.3	4.0	-1.6	1.2	-1.6	2.0	1.0
Patch foraging water rate 0 sec	0.2	0.3	0.8	-0.2	0.9	-0.2	-0.8	0.3
Patch foraging water rate 12 sec	0.8	1.7	3.3	0.2	-1.2	1.8	-1.6	-1.2
Patch foraging water rate 18 sec	0.1	0.2	0.3	-0.5	0.3	0.5	-0.4	0.3
Patch foraging water rate 24 sec	2.0	2.7	9.0	0.3	-0.1	1.2	-3.0	-1.8
Patch foraging water rate 6 sec	2.2	3.2	6.6	1.3	-1.2	1.6	-2.6	-1.9
Seeking ratio, delayed vs. immediate footshock	2.5	3.1	5.5	1.5	-1.3	1.2	-2.2	-2.3
Distance traveled before self-admin	0.1	0.2	0.5	-0.0	-0.3	0.7	-0.3	-0.3
Distance traveled after self-admin	1.2	1.5	3.2	0.9	-1.8	1.7	-0.2	-0.8
Extensor digitorum longus weight	0.3	1.1	2.3	1.5	0.1	-0.1	1.0	1.4
Bone: elastic displacement	0.2	0.3	0.8	-0.3	-0.1	0.2	0.9	0.6
Bone: elastic work	1.1	1.4	2.4	1.5	-1.5	1.4	-0.1	-0.6
Bone: endosteal estimation	1.0	2.1	3.9	1.1	-1.9	2.0	-0.6	-1.2
Bone: endosteal perimeter	0.9	1.9	3.1	0.8	-1.8	1.6	-1.0	-1.6
Epididymis fat weight	0.1	0.5	0.9	0.8	-0.6	0.9	-0.6	-0.3
Delta time in closed arm before/after self-admin	1.0	1.0	2.1	1.5	-1.1	0.9	-0.6	-0.6
Delta time in open arm before/after self-admin	0.9	0.9	1.4	-1.2	0.9	-0.7	1.0	0.9
Diff in mean of infusions in LGA sessions	0.7	0.8	1.7	-1.0	1.2	-1.3	-0.1	-0.0
Delay discount exponential model param	0.7	0.8	1.3	-0.8	0.6	-0.5	1.2	1.1
Extinction: sum of active levers before priming	2.4	2.6	5.5	2.0	-2.3	1.8	0.3	-0.4
Active lever presses in extinction session 6	1.7	1.7	3.3	0.9	-1.2	1.0	1.8	1.3
Bone: final force	1.4	2.2	5.2	2.3	-1.7	1.4	-0.7	-0.8
Bone: final moment	1.9	3.1	6.8	2.6	-2.0	1.7	-0.8	-1.0
Food consumed during 24 hour testing period	1.2	1.7	2.9	0.8	-0.7	1.3	-1.6	-1.7
Glucose	0.5	0.8	2.1	-0.5	0.1	-0.1	1.3	1.4
Heart weight	0.3	0.4	1.5	0.4	-0.0	0.5	-1.2	-0.5
Delay discount hyperbolic model param	0.7	0.7	1.4	-0.8	0.5	-0.4	1.2	1.1
Intermittent access intake day 1-15 change	1.2	2.4	4.2	2.0	-1.9	1.5	-0.7	-1.2
Intermittent access intake escalation	1.1	2.2	4.0	2.0	-1.8	1.6	-0.5	-0.9
Intermittent access intake escalation 2	0.8	0.9	1.7	1.1	-1.3	1.3	0.2	-0.2
Intermitt. access day 1 inactive lever presses	0.9	3.3	4.9	1.9	-1.7	1.3	-1.8	-2.2
Intermitt. access day 15 inactive lever presses	0.9	1.7	3.7	1.0	-0.7	0.0	-1.9	-1.9
Intermitt. access escalation Index	0.3	0.4	1.0	-0.6	0.2	0.0	-1.0	-0.7
Intermittent access day 1 total infusions	1.1	1.7	3.8	-1.9	1.2	-1.3	-1.0	-0.8
Intermittent access day 15 total infusions	0.5	0.7	1.9	0.1	-0.3	0.2	-1.4	-1.3
Intermittent access terminal intake (last 3 days)	0.6	0.8	1.8	-0.7	0.3	-0.2	-1.3	-1.2
Intermittent access total infusions	0.7	0.8	1.3	-1.0	0.4	-0.5	-1.2	-1.1
Intermittent access day 1 locomotion	1.5	1.9	3.3	-1.4	1.1	-1.1	-1.8	-1.4
Intermittent access day 15 total locomotion	0.5	0.9	2.2	-0.3	-0.1	-0.1	-1.5	-1.5
Intermittent access total locomotion	0.9	1.1	1.8	-1.3	1.1	-1.0	-1.0	-0.7
Intermittent access standard deviation	1.6	3.3	5.0	1.6	-2.2	1.6	-1.5	-2.1
Left kidney weight	2.1	9.6	17.9	4.2	-3.9	3.4	-1.1	-1.4
Right kidney weight	2.5	11.4	20.7	4.5	-4.0	4.3	-0.8	-1.0
Cocaine induced anxiety	0.1	0.2	0.4	0.6	0.0	-0.6	0.3	0.2
Post-drug Anxiety	0.4	0.4	1.8	0.2	0.5	-1.3	0.3	0.1
Baseline Anxiety	0.2	0.3	0.6	-0.3	0.2	-0.3	-0.7	-0.8
Tail length	3.8	14.7	22.6	4.6	-4.8	4.6	-1.8	-2.4
Length with tail	5.0	21.8	34.3	5.6	-5.9	5.6	-2.1	-2.8
Length without tail	2.9	9.3	17.1	4.1	-3.6	3.4	-1.5	-1.5
Times rat made contact with spout	0.4	0.4	1.1	-0.0	0.2	-0.0	1.0	1.0
Lifetime Intake	0.5	0.6	1.5	-1.2	0.6	-0.6	-0.7	-0.6
Liver weight, left	0.5	0.8	1.5	-0.7	0.8	-1.2	0.8	0.7
Liver weight, right	0.3	0.5	1.7	0.2	0.8	0.1	0.2	1.3
Locomotor activity	1.7	2.6	5.4	-1.2	0.9	-0.5	2.3	2.3
Locomotor testing distance	1.1	2.1	3.4	-1.5	1.0	-0.5	1.8	1.9
Locomotor testing rearing	0.8	1.6	3.1	-1.8	1.4	-0.6	0.9	1.3
Locomotion in novel chamber	0.8	1.1	1.6	-0.9	0.9	-0.8	1.3	1.2
Locomotion in novel chamber post-restriction	0.3	0.4	0.8	-0.9	0.8	-0.6	0.5	0.5
Fecal boli incidents, locomotor time 1	2.8	4.1	5.3	-2.3	2.3	-1.9	1.7	1.9
Change in fecal boli incidents, locomotor task	0.8	0.8	2.2	0.3	0.0	-0.3	1.5	1.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.4	-0.1	0.2	-0.6	0.2	0.3
Bouts of movement, locomotor time 1	1.8	2.1	4.0	0.7	-0.9	1.0	-2.0	-2.0
Total resting periods, locomotor time 1	1.3	1.4	2.9	0.5	-0.7	0.9	-1.6	-1.7
Rest time, locomotor task time 1	1.6	2.0	3.3	-1.3	1.8	-1.7	1.0	1.1
Distance moved, locomotor task time 1	0.4	0.6	1.1	0.5	-0.8	1.0	-0.8	-0.7
Vertical activity count, locomotor time 1	1.0	2.3	3.6	1.1	-1.7	1.9	-1.3	-1.5
Time >=10cm from walls, locomotor time 2	0.8	1.2	2.0	-1.2	1.4	-1.3	0.4	0.7
Bouts of movement, locomotor time 2	0.1	0.1	0.3	-0.2	-0.2	0.6	-0.4	-0.2
Total resting periods, locomotor time 2	0.1	0.1	0.4	-0.6	0.1	0.3	-0.1	0.2
Rest time, locomotor task time 2	0.7	0.9	1.2	-1.1	1.1	-0.8	0.8	0.9
Distance moved, locomotor task time 2	0.6	0.7	1.3	0.5	-0.5	0.9	-1.1	-0.9
Vertical activity count, locomotor time 2	1.4	2.0	2.3	1.4	-1.2	1.5	-1.4	-1.5
Light reinforcement 1	0.1	0.1	0.4	-0.3	0.2	0.3	-0.6	-0.2
Light reinforcement 2	1.0	1.5	3.6	-0.6	1.9	-1.3	0.1	1.3
Bone: marrow area	0.9	2.0	3.8	1.0	-1.9	1.9	-0.4	-1.1
Bone: maximum diameter	0.9	1.7	3.3	1.4	-1.8	1.3	-0.5	-1.1
Bone: maximum force	2.3	4.0	7.2	2.7	-2.3	2.1	-1.2	-1.3
Bone: maximum moment	2.8	4.9	8.5	2.9	-2.6	2.3	-1.3	-1.5
Mean time between licks in bursts	0.3	0.6	2.0	0.4	0.2	0.4	-1.4	-0.9
Mean num. licks in bursts	1.0	1.5	2.5	1.6	-1.4	1.5	0.7	0.7
Cd content in liver	0.1	0.2	0.3	-0.4	0.2	-0.5	0.6	0.0
Co content in liver	0.9	1.1	1.6	-0.8	0.8	-1.2	1.3	1.0
Cu content in liver	1.4	1.7	3.1	1.8	-1.2	1.4	-1.0	-0.8
Fe content in liver	0.4	0.5	0.7	-0.5	0.9	-0.7	0.8	0.7
K content in liver	0.0	0.0	0.1	-0.3	0.1	-0.0	0.2	0.2
Mg content in liver	1.2	1.3	2.6	-0.6	1.2	-0.7	1.2	1.6
Mn content in liver	2.4	2.7	5.3	-1.4	1.1	-1.2	2.3	1.9
Na content in liver	0.4	0.4	1.0	0.2	-1.0	0.7	-0.1	-0.7
Rb content in liver	0.5	0.6	2.3	0.0	0.6	-1.5	0.0	-0.4
Se content in liver	4.8	5.7	8.5	-1.9	2.8	-2.1	2.0	2.9
Sr content in liver	1.2	1.0	1.6	-1.2	0.6	-0.9	1.3	0.9
Zn content in liver	2.1	2.4	3.3	-0.9	1.8	-1.6	1.4	1.8
Bone: minimum diameter	2.6	4.8	6.2	1.6	-2.3	2.5	-2.0	-2.5
Time in familiar zone, hab. session 1	1.0	0.9	2.9	1.7	-0.7	0.8	0.3	0.7
Time in novel zone, hab. session 1	1.7	1.7	5.5	-2.4	1.4	-1.0	-0.2	-0.4
Total zone transitions, hab. session 1	0.5	0.6	1.7	0.5	-0.3	0.1	-1.3	-1.1
Total locomotion distance, hab. session 1	0.3	0.5	0.8	-0.1	-0.9	0.7	-0.7	-0.9
Locomotion velocity, hab. session 1	0.1	0.2	0.4	-0.1	-0.6	0.4	-0.2	-0.3
Time in familiar zone, hab. session 2	0.5	0.5	1.8	0.3	-0.6	0.2	1.3	0.6
Time in novel zone, hab. session 2	0.2	0.2	0.4	-0.4	0.5	-0.0	-0.6	-0.1
Total zone transitions, hab. session 2	1.4	1.8	3.7	-1.7	1.9	-1.3	-0.6	0.4
Total locomotion distance, hab. session 2	0.5	0.6	1.7	-1.3	0.6	-0.4	-0.7	-0.6
Locomotion velocity, hab. session 2	0.4	0.5	1.7	-1.3	0.7	-0.5	-0.5	-0.3
Novel to familiar place preference ratio	0.1	0.2	0.3	0.1	-0.4	0.2	-0.5	-0.6
Novelty place preference	0.2	0.2	0.4	-0.1	-0.4	0.2	-0.5	-0.7
Time in novel zone, NPP test	0.1	0.2	0.4	-0.2	-0.3	0.1	-0.5	-0.6
Total zone transitions, NPP test	0.3	0.4	1.1	0.5	-0.1	0.8	-1.1	-0.1
Total locomotion distance, NPP test	1.7	2.3	5.5	1.0	-1.9	2.4	-0.8	-0.7
Locomotion velocity, NPP test	1.3	1.8	5.0	0.9	-1.7	2.2	-0.6	-0.5
Intraocular pressure	0.2	0.3	0.5	-0.6	0.3	-0.7	0.3	-0.5
Delta distance traveled before/after self-admin	1.2	1.3	3.3	1.1	-1.8	1.1	-0.2	-0.8
Delta ambulatory time before/after self-admin	1.2	1.5	3.3	1.2	-1.8	1.2	-0.6	-1.1
Parametrial fat weight	1.1	2.6	6.1	0.0	0.5	-0.8	2.4	2.5
Pavlov. Cond. lever latency	0.3	0.3	0.8	0.9	-0.6	0.1	0.6	-0.0
Pavlov. Cond. magazine entry latency	1.0	1.2	3.8	-1.9	1.0	0.7	-0.0	0.9
Pavlov. Cond. change in total contacts	0.9	0.9	2.0	-1.3	0.8	0.1	-1.4	-0.6
Pavlov. Cond. index score	0.7	0.9	2.9	-1.7	1.0	0.4	-0.4	0.6
Pavlov. Cond. latency score	0.5	0.6	1.9	-1.4	0.8	0.4	-0.6	0.3
Pavlov. Cond. lever contacts	0.2	0.2	0.6	-0.8	0.3	0.2	-0.6	-0.1
Pavlov. Cond. magazine entry number	0.7	0.9	2.8	1.7	-0.8	-0.8	0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.4	1.3	0.2	0.8	-1.1	0.1	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	3.6	-1.9	1.2	0.3	-0.3	0.7
Pavlov. Cond. response bias	0.7	0.9	2.4	-1.5	0.7	0.7	0.2	1.0
Pavlov. Cond. lever latency	4.0	5.4	7.0	-2.5	2.5	-2.7	1.9	1.9
Pavlov. Cond. magazine entry latency	1.7	2.0	3.1	1.4	-1.7	1.7	-0.8	-1.2
Pavlov. Cond. change in total contacts	5.0	8.1	11.0	2.8	-3.3	3.0	-2.1	-2.9
Pavlov. Cond. index score	4.0	5.4	7.6	2.4	-2.7	2.8	-1.6	-1.9
Pavlov. Cond. latency score	3.4	4.5	6.3	2.1	-2.4	2.5	-1.6	-1.8
Pavlov. Cond. lever contacts	4.4	6.1	7.5	2.7	-2.7	2.7	-2.0	-2.1
Pavlov. Cond. magazine entry number	3.4	4.1	6.3	-2.2	2.4	-2.5	1.3	1.4
Pavlov. Cond. intertrial magazine entries	0.9	1.4	2.9	-1.2	1.3	-1.7	1.0	0.4
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.8	7.0	2.2	-2.6	2.6	-1.4	-1.8
Pavlov. Cond. response bias	5.6	7.6	9.1	3.0	-3.0	3.0	-2.3	-2.4
Time in closed arm before self-admin	1.0	1.2	2.5	-1.6	1.2	-1.5	-0.2	-0.2
Time in closed arm after self-admin	0.5	0.6	1.2	0.4	0.0	-0.6	-1.1	-1.0
Time in open arm before self-admin	2.7	2.9	6.1	2.0	-2.1	2.5	0.1	-0.2
Time in open arm after self-admin	0.6	0.6	1.2	0.5	-0.9	1.1	0.9	0.4
Bone: periosteal estimation	1.7	3.5	6.4	1.8	-2.4	2.5	-0.7	-1.2
Bone: periosteal perimeter	0.6	1.1	2.5	0.6	-1.6	1.4	-0.0	-0.7
Bone: post-yield work	2.3	3.3	4.5	1.6	-1.8	1.4	-2.0	-2.1
Progressive ratio test 1 active lever presses	0.5	0.7	1.6	-0.4	-0.2	0.0	-1.2	-1.3
Progressive ratio test 1 breakpoint	0.6	0.7	1.8	-0.3	-0.2	0.1	-1.3	-1.3
Progressive ratio test 1 inactive lever presses	1.9	2.7	7.8	0.2	-0.2	-0.4	-2.8	-2.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	-0.3	0.0	0.2	-0.5	-0.4
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	-0.3	0.1	0.2	-0.6	-0.3
Progressive ratio test 2 inactive lever presses	1.4	2.3	5.8	1.0	-0.3	-0.2	-2.4	-2.2
Incentive Sensitization - Responses	0.0	0.1	0.2	-0.0	0.3	0.1	-0.4	-0.1
Incentive Sensitization - Breakpoint	0.0	0.1	0.2	-0.0	0.3	0.0	-0.5	-0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.0	-0.1	-0.3	0.3	0.1
Progressive ratio	0.1	0.1	0.4	-0.6	0.4	0.1	-0.2	0.1
Food seeking constrained by brief footshock	1.0	1.2	2.0	1.1	-1.4	1.3	-0.6	-0.9
Seeking ratio, punishment vs. effort	0.4	0.6	1.0	1.0	-0.8	0.3	-0.8	-0.8
Retroperitoneal fat weight	1.5	6.4	16.3	-1.3	1.1	-0.6	3.5	4.0
Reaction time number correct	0.0	0.1	0.3	0.5	-0.1	0.4	-0.1	0.2
Reaction time mean minus median	0.1	0.2	0.7	0.4	-0.8	0.5	0.1	-0.4
Reaction time mean minus median AUC	0.3	0.7	1.7	1.0	-1.3	0.8	0.1	-0.4
Reaction time num false alarms	0.9	1.2	3.1	-1.2	0.9	-1.8	0.9	0.2
Reaction time num false alarms AUC	1.3	2.0	4.2	-1.6	1.1	-2.0	1.3	0.5
Reaction time trials correct on left	0.0	0.1	0.3	0.5	-0.1	0.4	-0.1	0.2
Reaction time trials on left	0.1	0.1	0.3	0.5	-0.1	0.4	-0.1	0.2
Reaction time mean	0.2	0.4	0.7	0.3	-0.8	0.7	-0.4	-0.7
Reaction time mean AUC	0.1	0.2	0.4	0.1	-0.6	0.5	-0.1	-0.4
Median of all reaction times	0.1	0.1	0.2	-0.1	-0.4	0.3	-0.4	-0.5
Reaction time omissions	0.2	0.2	0.5	-0.4	-0.1	0.1	0.7	0.7
Reaction time false alarm rate	1.1	1.5	3.4	-1.5	0.9	-1.8	1.0	0.1
Reaction time premature initiation rate	0.3	0.4	0.9	-1.0	0.4	-0.4	-0.5	-0.8
Reaction time premature initiations	0.1	0.2	0.4	-0.6	0.3	-0.2	-0.5	-0.7
Std. dev. reaction times	0.5	0.9	1.7	0.6	-1.3	0.9	-0.5	-1.1
Reaction time trials completed	0.1	0.1	0.3	0.5	-0.1	0.4	-0.1	0.2
Reaction time trials AUC	0.1	0.1	0.3	0.4	0.0	0.3	0.3	0.6
Run reversals in cocaine runway, females	1.5	1.5	2.1	1.5	-1.2	0.9	-1.1	-1.3
Run reversals in cocaine runway, males	2.5	2.5	6.3	-0.7	0.5	-0.5	2.5	2.3
Latency to leave start box in cocaine runway	1.0	1.1	1.6	1.3	-0.8	-0.1	-1.2	-1.3
Latency to leave start box in cocaine runway, F	1.0	1.2	2.8	1.3	-0.4	-0.0	-1.7	-1.1
Latency to leave start box in cocaine runway, M	0.2	0.1	0.3	-0.2	-0.4	-0.4	0.2	-0.6
Std. dev. time between licks in bursts	0.7	0.9	2.2	-0.8	0.4	0.0	-1.5	-1.3
Total sessions with >9 infusions	0.6	0.7	1.8	-1.4	0.9	-0.4	0.5	0.7
Short access day 1 total inactive lever presses	3.1	4.1	10.0	1.5	-0.6	0.5	-3.2	-2.8
Short access day 10 total inactive lever presses	2.0	4.9	8.6	2.5	-1.5	1.0	-2.9	-2.5
Short access day 1 total infusions	0.1	0.2	0.6	0.1	0.1	0.0	-0.8	-0.4
Short access day 10 total infusions	0.4	0.5	1.8	-1.3	0.3	-0.7	0.3	-0.0
Short access total infusions	0.5	0.6	1.7	-1.3	0.7	-0.7	0.3	0.3
Short access day 1 locomotion	0.3	0.4	0.8	-0.8	0.9	-0.7	-0.1	0.2
Short access day 10 total locomotion	0.4	0.7	1.4	-0.8	-0.1	0.2	-1.2	-1.2
Short access total locomotion	1.0	1.2	3.1	-1.8	1.3	-1.1	-0.1	0.2
One hour access (0.3 mA shock)	1.7	1.9	4.1	0.5	-0.8	0.8	-2.0	-2.0
Compulsive drug intake	0.4	0.5	1.5	0.2	0.2	-0.2	-1.2	-0.9
One hour access (shock baseline)	0.2	0.4	0.8	-0.3	-0.2	0.4	-0.8	-0.9
Social response proportion	0.8	0.9	1.6	1.3	-1.0	0.7	-0.6	-0.9
Social responses	0.0	0.0	0.1	0.4	-0.0	0.1	-0.1	-0.2
Social time	2.8	3.8	4.4	1.9	-1.8	2.0	-2.0	-2.1
Soleus weight	0.1	0.2	0.4	0.4	0.3	-0.1	0.5	0.6
Bone: stiffness	1.5	2.4	5.2	2.3	-1.5	1.4	-1.3	-1.0
Tibialis anterior weight	0.3	1.2	2.1	1.4	-0.3	0.1	1.4	1.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.3	0.4	-0.2	-0.3	-0.0
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.7	-0.8	0.1	-0.2	0.5	0.1
Time to tail flick, test, before self-admin	1.8	1.8	4.8	1.0	-0.6	0.4	-2.2	-1.7
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.2	0.2	-0.3	-0.0	0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.4	-0.4	0.3	0.3	-0.2
Delta time to tail flick, test, before/after SA	2.6	2.6	5.0	-1.4	1.1	-0.9	2.2	2.1
Tibia length	2.8	7.7	11.5	3.4	-3.2	3.1	-1.9	-1.7
Ambulatory time before self-admin	0.1	0.1	0.4	-0.0	-0.3	0.6	-0.3	-0.4
Ambulatory time after self-admin	2.6	3.1	5.8	1.6	-2.4	2.0	-0.8	-1.5
Bone: tissue strength	2.7	2.7	3.9	1.8	-1.7	1.0	-1.6	-2.0
Total heroin consumption	0.8	1.0	1.8	0.9	-0.8	0.5	-1.3	-1.3
Bone: trabecular number	1.3	2.1	3.4	1.8	-1.5	1.6	-1.2	-0.8
Bone: trabecular spacing	0.4	0.6	2.0	-0.8	-0.2	-0.1	1.4	0.5
Bone: trabecular thickness	0.2	0.3	0.8	0.9	-0.4	0.2	-0.7	-0.2
Bone: trabecular tissue density	2.6	3.8	7.5	-1.3	1.2	-1.4	2.7	2.5
Water consumed over 24 hours	0.7	0.9	2.0	1.3	-0.9	1.4	-0.5	-0.2
Number of responses in last shaping day	0.5	0.6	1.3	0.2	-0.4	1.1	-0.9	-0.7