Hub : Genes

Cox18

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Cox18	0.02	0.02	5.2e-03	0.02	0.01	0.01	0.01	5.0e-03	1.4e-02	5.5e-02	2.9e-02
2	BLA	intron excision ratio	chr14_18155213_18155534	0.07	0.06	4.6e-03	-0	0.02	0.01	-0	5.5e-01	2.0e-02	6.7e-02	4.4e-01
3	Liver	gene expression	Cox18	0.04	0.03	9.7e-04	-0	0.02	0.01	0	6.0e-01	5.6e-03	4.5e-02	1.3e-01
4	IC	gene expression	Cox18	0.49	0.16	6.5e-03	0.07	0.02	0.06	0.08	7.0e-04	5.2e-02	1.7e-03	4.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.8	3.4	4.7	2.1	2.1	-2.2	0.3
Area under the delay curve	0.1	0.1	0.2	0.2	-0.3	0.5	-0.0
BMI with tail	4.2	14.7	18.1	4.3	4.0	-3.5	3.5
BMI without tail	0.7	3.6	4.5	1.8	2.1	-1.8	1.9
Body weight	0.0	0.1	0.2	-0.5	0.1	0.1	0.0
Weight adjusted by age	0.2	0.7	1.7	0.2	0.7	-0.8	1.3
Bone surface	0.6	1.3	2.3	0.9	1.3	-1.5	-0.3
Bone volume	0.6	1.3	1.9	1.1	1.2	-1.4	-0.7
Breakpoint value in progressive ratio session	0.0	0.1	0.2	0.1	0.3	-0.4	-0.0
Number of licking bursts	0.3	0.8	1.4	-1.2	-0.8	0.9	0.6
Context. condit. distance diff. score	1.7	2.1	4.6	1.7	0.4	-0.8	-2.1
Locomotion velocity, session 1	0.6	0.7	0.8	0.9	0.8	-0.6	0.9
Locomotion distance, session 1	0.7	0.9	2.2	1.5	0.8	-0.7	-0.5
Locomotion velocity, session 2	0.2	0.3	0.4	0.5	0.5	-0.4	-0.6
Locomotion distance, session 2	0.2	0.2	0.6	0.5	-0.1	0.1	-0.7
Locomotion velocity, session 3	0.2	0.3	0.8	0.9	0.4	-0.3	-0.1
Locomotion distance, session 3	1.9	2.2	3.4	1.8	1.6	-1.2	1.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	-0.2	-0.4	0.5	0.2
Stereotopy head waving duration, day 3	0.1	0.2	0.2	0.1	-0.5	0.5	-0.5
Locomotion velocity, session 7	0.6	0.7	2.2	0.7	-0.1	-0.1	-1.5
Locomotion distance, session 7	0.2	0.3	0.5	0.7	0.3	-0.3	-0.7
Stereotopy head waving bouts, day 7	0.5	0.6	1.2	0.3	0.8	-0.6	1.1
Stereotopy head waving duration, day 7	0.3	0.4	1.4	-0.0	0.3	-0.1	1.2
Locomotion velocity, session 8	3.2	3.8	9.4	3.1	1.7	-1.7	-0.1
Locomotion distance, session 8	1.9	2.7	5.6	2.4	1.0	-1.3	-1.6
Degree of sensitization distance	1.9	2.0	4.5	-1.1	-1.3	0.9	-2.1
Degree of sensitization stereotypy	0.2	0.2	0.9	-0.2	0.3	-0.1	0.9
Conditioned locomotion	0.1	0.1	0.3	0.6	0.0	-0.1	-0.2
Cocaine response after cond. corrected	0.2	0.3	0.4	-0.7	-0.5	0.5	-0.2
Cocaine response after cond. not corrected	0.0	0.1	0.1	0.0	0.3	-0.3	-0.1
Cocaine response before conditioning	1.7	2.0	3.1	1.4	1.7	-1.8	0.6
Saline control response	0.4	0.6	0.7	0.8	0.8	-0.8	-0.5
Bone: connectivity density	2.4	3.8	5.8	2.4	2.1	-2.2	0.3
Bone: cortical apparent density	0.3	0.4	1.3	0.2	0.5	-0.1	1.2
Bone: cortical area	0.9	1.5	2.4	1.1	1.2	-1.6	-0.8
Bone: cortical porosity	0.2	0.2	0.8	0.3	0.1	0.1	0.9
Bone: cortical porosity	0.3	0.3	1.1	0.2	0.2	-0.1	1.0
Bone: cortical thickness	3.2	5.3	8.0	2.6	2.5	-2.8	0.2
Bone: cortical thickness	0.7	0.8	1.8	0.3	0.7	-1.0	-1.3
Bone: cortical tissue density	0.3	0.5	1.7	0.2	0.5	-0.1	1.3
Condit. Reinf. active minus inactive responses	0.5	0.6	1.2	-1.1	-0.7	0.8	0.4
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.3	-1.1	-0.7	0.8	0.6
Condit. Reinf. active responses	0.1	0.2	0.3	-0.5	-0.4	0.4	-0.2
Condit. Reinf. inactive responses	0.2	0.3	0.3	0.5	0.4	-0.5	-0.6
Incentive salience index mean	0.0	0.1	0.1	-0.3	-0.3	0.3	0.0
Condit. Reinf. lever presses	0.2	0.3	0.5	0.7	0.6	-0.7	0.0
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	0.3	0.6	-0.5	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.5	-0.7	0.2	-0.2	0.3
Condit. Reinf. active responses	0.0	0.0	0.2	-0.0	0.0	0.0	-0.4
Condit. Reinf. inactive responses	0.1	0.2	0.7	0.4	-0.2	0.1	-0.8
Condit. Reinf. lever presses	1.4	2.0	3.7	-1.1	-1.3	1.2	-1.9
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	0.1	0.1	0.0	-0.6
Conditioned reinforcement - actives	0.1	0.4	0.7	-0.4	-0.5	0.6	-0.8
Conditioned reinforcement - inactives	0.3	0.7	2.2	-0.4	-0.6	0.4	-1.5
Conditioned locomotion	2.5	3.7	5.1	-2.0	-2.0	2.3	-1.4
Patch foraging indifference point 0 sec	0.1	0.3	0.8	0.6	0.4	0.0	0.9
Patch foraging indifference point AUC	0.2	0.4	1.0	-0.1	-0.6	0.5	-1.0
Delay disc. indifference point, 0s delay	0.0	0.1	0.2	0.1	-0.0	0.2	0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.5	0.7	0.2	-0.1	0.1
Delay disc. indifference point, 2s delay	0.5	0.6	0.9	-0.4	-0.8	0.9	-0.8
Delay disc. indifference point, 24s delay	0.9	1.4	2.5	-1.1	-1.4	1.6	-0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.5	-0.3	0.4	-0.1
Delay disc. indifference point, 8s delay	0.3	0.5	1.2	0.6	0.6	-0.4	1.1
Indifference point function ln k	0.0	0.1	0.3	0.2	0.5	-0.5	-0.1
Indifference point function log k	0.0	0.1	0.3	0.2	0.5	-0.5	-0.1
Patch foraging total patch changes 0 sec	0.1	0.2	0.6	0.5	0.3	0.1	0.8
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.5	-0.1	0.2	0.4
Patch foraging total patch changes 18 sec	0.1	0.1	0.4	-0.3	-0.0	0.2	0.6
Patch foraging total patch changes 24 sec	0.0	0.2	0.3	0.5	-0.2	0.5	-0.2
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	0.6	-0.1	0.3	0.5
Patch foraging time to switch 0 sec	0.3	1.2	3.2	0.3	1.0	-0.9	1.8
Patch foraging water rate 0 sec	0.2	0.8	1.2	-0.5	-0.9	0.9	-1.1
Patch foraging water rate 12 sec	0.0	0.1	0.1	0.4	-0.2	0.4	0.0
Patch foraging water rate 18 sec	0.2	0.4	0.7	-0.6	-0.7	0.8	-0.3
Patch foraging water rate 24 sec	0.8	1.1	1.6	-1.3	-1.0	1.0	-0.9
Patch foraging water rate 6 sec	1.2	1.8	2.4	-0.8	-1.6	1.5	-1.4
Seeking ratio, delayed vs. immediate footshock	0.7	0.9	2.1	-0.2	-0.9	0.9	-1.4
Distance traveled before self-admin	0.7	1.6	2.2	-1.3	-1.5	1.4	-0.9
Distance traveled after self-admin	3.5	6.1	7.5	-2.3	-2.7	2.6	-2.3
Extensor digitorum longus weight	11.1	44.2	52.1	6.0	7.2	-6.6	6.7
Bone: elastic displacement	1.7	2.1	3.4	1.5	1.7	-1.8	0.3
Bone: elastic work	2.6	3.4	5.1	1.6	2.2	-2.3	1.1
Bone: endosteal estimation	1.5	3.7	5.7	-2.4	-1.9	1.8	-1.4
Bone: endosteal perimeter	0.4	1.0	2.2	-1.5	-1.0	0.8	-0.5
Epididymis fat weight	0.2	0.9	1.7	-0.8	-1.1	1.3	-0.0
Delta time in closed arm before/after self-admin	0.3	0.3	0.8	0.4	0.3	-0.3	0.9
Delta time in open arm before/after self-admin	0.2	0.3	0.6	-0.2	-0.6	0.4	-0.8
Diff in mean of infusions in LGA sessions	0.2	0.3	0.7	-0.7	0.2	-0.4	-0.8
Delay discount exponential model param	0.1	0.2	0.4	-0.1	0.5	-0.6	0.2
Extinction: sum of active levers before priming	0.3	0.5	1.0	-0.7	-0.8	1.0	-0.1
Active lever presses in extinction session 6	2.1	2.1	3.1	-1.8	-1.6	1.6	-0.6
Bone: final force	0.1	0.2	0.6	-0.5	-0.3	-0.0	-0.7
Bone: final moment	0.2	0.4	0.7	-0.8	-0.5	0.3	-0.6
Food consumed during 24 hour testing period	0.2	0.5	0.7	0.8	0.7	-0.7	0.5
Glucose	1.2	1.9	2.3	-1.5	-1.5	1.5	-1.0
Heart weight	0.2	0.4	0.6	0.6	0.7	-0.8	0.2
Delay discount hyperbolic model param	0.1	0.2	0.3	-0.2	0.4	-0.6	0.2
Intermittent access intake day 1-15 change	0.0	0.3	0.5	-0.7	-0.2	0.6	0.4
Intermittent access intake escalation	0.0	0.2	0.3	-0.5	-0.1	0.4	0.6
Intermittent access intake escalation 2	1.0	1.6	2.2	-1.2	-1.2	1.5	-1.2
Intermitt. access day 1 inactive lever presses	0.1	1.5	3.3	1.8	1.0	-1.1	-0.7
Intermitt. access day 15 inactive lever presses	0.2	0.9	3.6	-0.2	-0.3	-0.1	-1.9
Intermitt. access escalation Index	0.2	0.5	1.5	-1.2	-0.4	0.2	0.4
Intermittent access day 1 total infusions	0.3	0.9	1.1	-0.9	-1.0	0.9	-0.9
Intermittent access day 15 total infusions	0.7	1.6	2.0	-1.2	-1.3	1.4	-1.2
Intermittent access terminal intake (last 3 days)	2.4	4.1	5.3	-1.6	-2.1	2.1	-2.3
Intermittent access total infusions	1.5	1.7	2.2	-1.0	-1.4	1.3	-1.5
Intermittent access day 1 locomotion	0.3	0.6	0.7	-0.8	-0.8	0.8	-0.7
Intermittent access day 15 total locomotion	0.8	2.9	5.0	-0.7	-1.9	1.7	-2.2
Intermittent access total locomotion	2.0	2.4	3.1	-1.6	-1.7	1.8	-1.2
Intermittent access standard deviation	0.1	0.5	1.6	0.2	-0.4	0.4	-1.3
Left kidney weight	0.0	0.1	0.4	-0.2	0.2	-0.2	-0.7
Right kidney weight	0.3	2.0	2.8	-1.7	-1.3	1.1	-1.4
Cocaine induced anxiety	0.2	0.4	1.5	-1.2	0.2	-0.2	0.3
Post-drug Anxiety	0.2	0.3	0.4	-0.4	0.7	-0.7	0.2
Baseline Anxiety	0.1	0.2	0.9	0.9	0.2	-0.2	-0.2
Tail length	2.8	15.0	20.2	-4.5	-4.0	3.8	-3.0
Length with tail	5.3	23.4	33.7	-5.8	-4.9	4.5	-4.0
Length without tail	0.9	4.8	6.8	-2.6	-2.1	1.8	-2.2
Times rat made contact with spout	0.5	0.5	0.9	0.8	0.6	-0.5	1.0
Lifetime Intake	0.7	0.9	1.4	-1.0	-1.1	1.2	-0.4
Liver weight, left	0.6	1.1	2.1	-0.9	-1.2	1.5	-0.0
Liver weight, right	0.4	0.7	1.5	-0.4	-1.0	1.2	0.2
Locomotor activity	0.3	0.4	0.8	-0.3	-0.6	0.6	-0.9
Locomotor testing distance	0.1	0.3	0.9	0.5	-0.2	-0.1	-1.0
Locomotor testing rearing	0.1	0.2	0.6	0.6	0.0	-0.2	-0.7
Locomotion in novel chamber	0.2	0.3	0.6	-0.4	-0.7	0.8	-0.2
Locomotion in novel chamber post-restriction	0.2	0.7	0.9	-0.7	-1.0	0.9	-0.7
Fecal boli incidents, locomotor time 1	0.0	0.1	0.1	-0.2	0.1	-0.3	0.3
Change in fecal boli incidents, locomotor task	0.4	0.5	1.2	-1.1	-0.4	0.4	0.6
Time >=10cm from walls, locomotor time 1	0.9	1.1	3.4	-1.0	0.0	0.0	1.8
Bouts of movement, locomotor time 1	0.3	0.4	0.6	-0.6	-0.8	0.6	-0.6
Total resting periods, locomotor time 1	0.5	0.6	0.8	-0.8	-0.9	0.8	-0.5
Rest time, locomotor task time 1	0.6	0.9	1.5	-1.2	-1.0	0.8	-0.8
Distance moved, locomotor task time 1	0.1	0.3	0.5	0.7	0.6	-0.4	0.4
Vertical activity count, locomotor time 1	0.1	0.4	0.7	-0.5	-0.7	0.9	-0.0
Time >=10cm from walls, locomotor time 2	0.2	0.5	1.1	0.1	0.7	-0.8	1.0
Bouts of movement, locomotor time 2	0.3	0.9	1.2	-0.4	-1.1	1.0	-1.1
Total resting periods, locomotor time 2	0.2	0.7	0.9	-0.4	-1.0	0.9	-0.9
Rest time, locomotor task time 2	0.7	1.1	1.6	-0.8	-1.3	1.0	-1.2
Distance moved, locomotor task time 2	1.2	1.6	2.2	1.1	1.5	-1.1	1.3
Vertical activity count, locomotor time 2	0.1	0.2	0.6	-0.2	0.2	0.1	0.8
Light reinforcement 1	0.0	0.1	0.2	0.1	-0.5	0.4	-0.1
Light reinforcement 2	0.1	0.3	1.0	1.0	0.2	-0.1	0.3
Bone: marrow area	1.3	3.3	5.2	-2.3	-1.8	1.7	-1.4
Bone: maximum diameter	0.1	0.1	0.4	-0.1	0.4	-0.6	-0.2
Bone: maximum force	0.1	0.3	1.0	-0.2	-0.1	-0.2	-1.0
Bone: maximum moment	0.2	0.4	0.8	-0.6	-0.4	0.2	-0.9
Mean time between licks in bursts	0.2	1.3	2.7	-1.6	-1.1	1.1	-0.1
Mean num. licks in bursts	0.3	0.9	2.1	1.4	0.8	-0.9	-0.2
Cd content in liver	2.2	2.4	3.8	0.7	1.7	-1.6	2.0
Co content in liver	0.4	0.5	1.1	-1.0	-0.6	0.5	-0.6
Cu content in liver	0.1	0.1	0.2	-0.2	-0.2	0.3	-0.5
Fe content in liver	0.3	0.4	1.3	-0.5	0.3	-0.2	1.1
K content in liver	0.2	0.2	0.7	0.8	-0.1	0.0	-0.2
Mg content in liver	0.1	0.1	0.4	0.1	-0.3	0.2	-0.6
Mn content in liver	1.6	1.8	2.3	1.5	1.5	-1.5	0.7
Na content in liver	0.2	0.3	0.6	0.8	-0.2	0.4	0.6
Rb content in liver	0.6	0.7	1.4	-1.2	-0.4	0.4	1.1
Se content in liver	0.3	0.3	0.6	0.2	-0.6	0.5	-0.8
Sr content in liver	1.2	1.1	1.6	0.8	0.8	-1.3	-1.1
Zn content in liver	0.2	0.2	0.5	0.7	0.4	-0.4	0.0
Bone: minimum diameter	4.8	9.2	10.2	-3.2	-3.1	2.8	-3.1
Time in familiar zone, hab. session 1	1.1	1.2	2.8	1.7	0.9	-1.1	-0.3
Time in novel zone, hab. session 1	3.9	4.4	8.4	-2.9	-2.0	2.2	0.4
Total zone transitions, hab. session 1	0.2	0.3	0.4	0.5	-0.4	0.6	-0.6
Total locomotion distance, hab. session 1	1.0	1.4	4.0	0.7	-0.9	0.7	-2.0
Locomotion velocity, hab. session 1	0.8	1.1	2.8	1.3	-0.2	0.1	-1.7
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.3	0.1	-0.2	0.6
Time in novel zone, hab. session 2	0.4	0.4	0.7	-0.8	-0.5	0.5	-0.7
Total zone transitions, hab. session 2	0.6	0.8	2.9	0.4	-0.2	-0.2	-1.7
Total locomotion distance, hab. session 2	1.2	1.6	5.7	0.3	-0.7	0.2	-2.4
Locomotion velocity, hab. session 2	1.0	1.4	4.9	0.5	-0.5	0.1	-2.2
Novel to familiar place preference ratio	0.1	0.1	0.2	0.0	-0.3	0.4	-0.2
Novelty place preference	0.1	0.2	0.4	-0.2	-0.5	0.6	-0.1
Time in novel zone, NPP test	0.3	0.3	0.7	-0.4	-0.7	0.9	-0.2
Total zone transitions, NPP test	0.7	1.1	1.5	1.2	1.1	-1.2	-0.2
Total locomotion distance, NPP test	0.5	0.7	1.4	1.2	0.5	-0.6	-0.8
Locomotion velocity, NPP test	0.7	1.0	2.0	1.4	0.8	-1.0	-0.6
Intraocular pressure	1.4	2.3	3.3	-1.7	-1.0	1.5	1.8
Delta distance traveled before/after self-admin	0.6	0.7	0.8	-0.8	-0.9	0.9	-0.7
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	-0.6	-0.4	0.5	-0.1
Parametrial fat weight	0.7	1.5	1.9	-1.3	-1.4	1.2	-1.1
Pavlov. Cond. lever latency	0.3	0.4	1.4	-0.3	0.4	-0.3	1.2
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	0.6	0.2	-0.1	0.4
Pavlov. Cond. change in total contacts	0.2	0.2	0.8	0.1	-0.1	0.0	-0.9
Pavlov. Cond. index score	0.2	0.2	0.8	0.9	0.2	-0.1	-0.3
Pavlov. Cond. latency score	0.2	0.3	0.8	0.9	0.2	-0.2	-0.4
Pavlov. Cond. lever contacts	0.3	0.3	1.0	0.5	-0.1	-0.0	-1.0
Pavlov. Cond. magazine entry number	0.0	0.1	0.2	-0.4	0.0	-0.0	0.2
Pavlov. Cond. intertrial magazine entries	0.6	0.7	2.6	0.1	-0.4	0.2	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.7	0.8	0.1	-0.1	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.3	0.2	-0.3	0.4	-0.5
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.0	0.1	-0.2	0.2
Pavlov. Cond. magazine entry latency	0.3	0.5	1.1	-1.0	-0.6	0.6	-0.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.3	0.1	-0.0	0.2
Pavlov. Cond. index score	0.2	0.2	0.4	-0.7	-0.4	0.4	-0.5
Pavlov. Cond. latency score	0.0	0.1	0.1	-0.3	-0.0	0.0	-0.3
Pavlov. Cond. lever contacts	0.2	0.4	0.4	-0.5	-0.6	0.6	-0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.5	0.0	-0.1	-0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.1	-0.4	0.2	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.5	-0.7	-0.5	0.5	-0.5
Pavlov. Cond. response bias	0.4	0.6	0.9	-0.9	-0.8	0.9	-0.4
Time in closed arm before self-admin	0.3	0.5	2.1	-0.3	-0.1	-0.2	-1.4
Time in closed arm after self-admin	0.7	0.8	2.0	0.8	0.3	-0.7	-1.4
Time in open arm before self-admin	0.5	0.7	1.7	-0.8	-0.2	0.4	1.3
Time in open arm after self-admin	1.3	1.4	2.2	-1.2	-1.4	1.5	0.3
Bone: periosteal estimation	0.3	0.7	1.5	-1.0	-0.6	0.3	-1.2
Bone: periosteal perimeter	0.0	0.1	0.1	0.0	0.1	-0.3	-0.3
Bone: post-yield work	1.1	1.9	2.7	-1.6	-1.5	1.4	-0.8
Progressive ratio test 1 active lever presses	2.3	4.0	5.2	-2.0	-2.3	2.2	-1.4
Progressive ratio test 1 breakpoint	2.3	3.9	5.1	-1.9	-2.2	2.2	-1.4
Progressive ratio test 1 inactive lever presses	0.3	0.8	3.0	0.5	-0.1	-0.1	-1.7
Progressive ratio test 2 active lever presses	2.0	2.8	3.4	-1.5	-1.8	1.8	-1.6
Progressive ratio test 2 breakpoint	2.2	2.8	3.4	-1.4	-1.8	1.8	-1.6
Progressive ratio test 2 inactive lever presses	0.7	2.2	5.6	-0.7	-1.3	1.0	-2.4
Incentive Sensitization - Responses	0.6	1.5	1.6	-1.3	-1.3	1.1	-1.3
Incentive Sensitization - Breakpoint	0.7	1.6	1.7	-1.3	-1.3	1.2	-1.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.5	0.1	-0.1	-0.0
Progressive ratio	0.1	0.2	0.3	0.3	0.5	-0.4	-0.3
Food seeking constrained by brief footshock	0.3	0.3	0.6	0.5	0.8	-0.5	0.5
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.0	-0.3	0.3	0.1
Retroperitoneal fat weight	0.4	2.0	3.5	-1.9	-1.4	1.4	-0.5
Reaction time number correct	0.1	0.4	1.1	-1.0	-0.6	0.6	0.2
Reaction time mean minus median	0.1	0.6	1.4	-1.2	-0.5	0.7	0.2
Reaction time mean minus median AUC	0.1	0.5	1.3	-1.1	-0.5	0.7	-0.2
Reaction time num false alarms	0.1	0.2	0.5	0.7	-0.2	0.1	-0.3
Reaction time num false alarms AUC	0.1	0.1	0.4	0.7	-0.2	0.2	-0.0
Reaction time trials correct on left	0.1	0.4	1.1	-1.0	-0.6	0.6	0.2
Reaction time trials on left	0.1	0.4	1.1	-1.0	-0.5	0.6	0.2
Reaction time mean	0.3	0.6	1.6	-1.3	-0.6	0.5	-0.5
Reaction time mean AUC	0.3	0.8	1.8	-1.3	-0.8	0.7	-0.6
Median of all reaction times	0.3	0.5	1.3	-1.2	-0.5	0.3	-0.6
Reaction time omissions	0.2	0.4	1.0	-0.1	1.0	-0.7	0.1
Reaction time false alarm rate	0.2	0.2	0.8	0.9	-0.1	0.1	-0.1
Reaction time premature initiation rate	0.3	0.5	1.9	0.5	-0.2	0.0	-1.4
Reaction time premature initiations	0.2	0.5	1.7	-0.1	-0.5	0.4	-1.3
Std. dev. reaction times	0.2	0.6	1.3	-1.1	-0.5	0.7	-0.4
Reaction time trials completed	0.1	0.4	1.1	-1.0	-0.5	0.6	0.2
Reaction time trials AUC	0.2	0.6	1.5	-1.2	-0.6	0.7	0.3
Run reversals in cocaine runway, females	0.1	0.1	0.4	0.2	-0.0	-0.1	-0.6
Run reversals in cocaine runway, males	0.8	0.9	1.5	0.4	1.0	-0.9	1.2
Latency to leave start box in cocaine runway	2.0	2.7	3.2	-1.5	-1.8	1.5	-1.8
Latency to leave start box in cocaine runway, F	2.5	3.1	5.7	-1.1	-1.8	1.5	-2.4
Latency to leave start box in cocaine runway, M	0.5	0.5	1.4	-1.2	-0.6	0.5	0.2
Std. dev. time between licks in bursts	0.3	0.5	0.8	-0.9	-0.6	0.8	0.5
Total sessions with >9 infusions	0.7	0.8	1.8	-0.8	-0.4	0.9	1.3
Short access day 1 total inactive lever presses	0.3	0.5	0.7	-0.3	-0.8	0.7	-0.8
Short access day 10 total inactive lever presses	0.4	2.8	3.8	1.9	1.4	-1.8	-1.6
Short access day 1 total infusions	0.2	0.4	0.8	-0.2	-0.8	0.9	0.2
Short access day 10 total infusions	0.2	0.3	0.7	-0.1	-0.7	0.8	0.0
Short access total infusions	0.3	0.4	1.3	-0.4	-0.3	0.5	1.1
Short access day 1 locomotion	1.1	1.9	3.4	-1.4	-1.4	1.9	0.1
Short access day 10 total locomotion	0.0	0.2	0.3	-0.0	-0.4	0.5	-0.5
Short access total locomotion	0.5	0.7	1.3	-0.9	-0.8	1.1	0.4
One hour access (0.3 mA shock)	4.3	5.1	5.6	-2.3	-2.3	2.4	-2.0
Compulsive drug intake	1.7	2.5	3.5	1.7	1.8	-1.9	0.5
One hour access (shock baseline)	1.9	5.0	7.0	-2.2	-2.6	2.6	-1.3
Social response proportion	0.1	0.1	0.1	-0.4	-0.2	0.4	0.2
Social responses	0.4	0.6	1.0	-0.8	-0.9	1.0	-0.2
Social time	0.2	0.3	0.4	-0.6	-0.5	0.6	-0.6
Soleus weight	3.5	10.3	16.6	4.1	3.4	-3.5	1.1
Bone: stiffness	0.7	1.2	2.4	-0.5	-1.1	1.0	-1.6
Tibialis anterior weight	3.8	13.0	15.1	3.9	3.9	-3.5	3.1
Time to tail flick, vehicle, before self-admin	2.2	2.7	3.8	-1.5	-1.6	1.5	-1.9
Time to tail flick, vehicle, after self-admin	0.5	1.0	3.0	-0.3	-0.6	0.6	-1.7
Time to tail flick, test, before self-admin	0.2	0.3	0.9	-0.2	0.0	-0.3	-1.0
Time to tail flick, test, after self-admin	3.3	3.5	4.5	-2.1	-1.9	1.8	-1.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	0.8	0.7	-0.5	0.2
Delta time to tail flick, test, before/after SA	0.9	1.1	1.6	-1.1	-1.2	1.3	-0.5
Tibia length	1.6	4.5	9.8	-2.1	-1.6	1.0	-3.1
Ambulatory time before self-admin	0.4	1.2	1.6	-0.8	-1.3	1.2	-0.9
Ambulatory time after self-admin	2.8	4.5	5.3	-1.8	-2.3	2.2	-2.2
Bone: tissue strength	0.4	0.4	0.5	-0.5	-0.7	0.7	-0.6
Total heroin consumption	2.7	3.2	4.9	-2.2	-1.8	1.7	-1.4
Bone: trabecular number	1.0	2.0	3.1	1.8	1.5	-1.6	-0.0
Bone: trabecular spacing	0.0	0.1	0.1	0.0	-0.3	0.3	-0.4
Bone: trabecular thickness	0.4	0.6	0.9	0.8	0.9	-1.0	-0.0
Bone: trabecular tissue density	0.1	0.1	0.5	-0.3	0.0	0.0	0.7
Water consumed over 24 hours	0.0	0.0	0.0	0.2	-0.0	0.0	0.2
Number of responses in last shaping day	0.5	0.7	2.2	0.4	-0.4	0.4	1.5