Hub : Genes

Comp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Comp 0.83 0.09 6.0e-12 0.37 0.26 0.37 0.04 1.1e-09 7.9e-07 9.0e-10 4.2e-02
2 IL gene expression Comp 0.24 0.13 4.2e-04 0.23 0.07 0.18 0 3.7e-06 1.0e-02 4.2e-05 2.7e-01
3 PL gene expression Comp 0.36 0.12 0.0e+00 0.27 0.26 0.27 0.28 6.2e-30 1.1e-28 7.8e-30 2.7e-30
4 IC gene expression Comp 0.61 0.12 0.0e+00 0.44 0.43 0.45 0.45 5.4e-20 1.9e-19 1.2e-20 1.2e-20
5 PL alternative TSS XM_006252822.5 0.05 0.03 1.0e-04 0.02 0.02 0.03 0.02 1.6e-03 1.3e-03 9.0e-04 6.7e-03
6 Brain gene expression Comp 0.55 0.15 0.0e+00 0.22 0.25 0.25 0.24 4.3e-20 3.7e-23 1.9e-23 3.0e-22
7 pVTA alternative TSS XM_006252822.5 0.1 0.05 7.5e-06 0.05 0.07 0.07 0.07 5.0e-05 1.4e-06 3.3e-06 4.0e-06
8 pVTA alternative TSS NM_012834.2 0.1 0.05 5.9e-06 0.05 0.07 0.07 0.07 5.2e-05 1.4e-06 3.1e-06 5.0e-06
9 pVTA gene expression Comp 0.28 0.09 3.5e-13 0.13 0.19 0.19 0.19 1.5e-10 5.0e-15 4.8e-15 5.0e-15
10 Liver gene expression Comp 0.21 0.08 0.0e+00 0.24 0.24 0.25 0.25 1.8e-26 9.0e-27 1.8e-27 5.2e-28
11 Adipose gene expression Comp 0.06 0.04 5.6e-05 0.04 0.04 0.04 0.04 1.9e-05 4.0e-05 6.2e-05 4.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density3.35.710.5-3.2-2.7-2.4-2.22.4-2.02.4-2.43.2-1.3-1.0
Area under the delay curve0.10.10.40.40.20.30.1-0.3-0.1-0.10.1-0.6-0.00.1
BMI with tail1.65.48.6-2.6-2.7-2.6-2.72.2-2.91.9-1.8-0.52.42.2
BMI without tail2.57.711.8-2.9-3.1-3.2-3.22.7-3.42.3-2.3-0.83.02.8
Body weight5.021.730.6-5.3-5.3-5.5-5.55.2-5.54.8-4.70.53.22.9
Weight adjusted by age1.52.23.8-1.7-1.8-1.8-1.91.6-1.41.3-1.30.11.11.4
Bone surface1.83.27.3-2.7-2.3-1.9-1.81.7-1.91.6-1.62.0-0.3-0.2
Bone volume3.05.510.7-3.3-2.9-2.5-2.52.4-2.42.3-2.32.4-0.2-0.1
Breakpoint value in progressive ratio session0.10.20.6-0.2-0.2-0.1-0.0-0.0-0.4-0.20.3-0.60.60.8
Number of licking bursts0.20.30.80.90.80.60.7-0.50.4-0.10.1-0.3-0.6-0.7
Context. condit. distance diff. score0.91.02.41.61.21.01.1-0.61.4-0.10.00.5-1.1-1.4
Locomotion velocity, session 11.11.23.10.91.01.10.8-1.20.2-1.21.2-1.81.00.9
Locomotion distance, session 10.81.11.90.81.01.41.2-1.30.9-1.21.2-0.1-0.7-0.7
Locomotion velocity, session 20.91.04.20.1-0.1-0.4-0.50.1-0.70.2-0.2-2.01.61.8
Locomotion distance, session 20.91.22.20.81.11.41.3-1.50.9-1.41.4-0.2-0.8-0.7
Locomotion velocity, session 32.42.76.02.42.01.82.0-1.72.0-1.51.4-1.0-0.4-0.5
Locomotion distance, session 30.50.62.4-0.10.20.40.5-0.10.6-0.20.11.6-1.2-1.4
Stereotopy head waving bouts, day 32.83.37.82.82.21.92.2-1.42.2-0.70.6-0.1-2.0-2.0
Stereotopy head waving duration, day 31.62.05.72.41.81.41.6-1.11.7-0.50.4-0.5-1.3-1.1
Locomotion velocity, session 71.11.21.91.31.11.41.2-1.31.2-1.41.4-0.6-0.3-0.1
Locomotion distance, session 70.40.51.00.50.51.00.8-1.00.7-1.01.00.1-0.5-0.5
Stereotopy head waving bouts, day 70.30.31.00.60.40.20.30.10.60.3-0.30.5-1.0-1.0
Stereotopy head waving duration, day 70.20.20.80.90.60.10.30.10.60.3-0.3-0.3-0.3-0.3
Locomotion velocity, session 84.65.511.43.42.72.82.6-2.72.6-2.32.2-1.6-0.3-0.4
Locomotion distance, session 80.60.91.51.11.01.21.1-1.11.0-0.80.80.1-0.7-0.9
Degree of sensitization distance0.50.51.50.70.50.70.4-0.80.3-0.80.8-1.20.40.6
Degree of sensitization stereotypy0.30.40.6-0.5-0.4-0.6-0.50.7-0.10.8-0.80.8-0.5-0.6
Conditioned locomotion0.10.20.6-0.20.1-0.3-0.20.4-0.10.4-0.40.2-0.5-0.8
Cocaine response after cond. corrected0.40.41.60.60.5-0.10.30.40.80.4-0.50.5-1.3-1.1
Cocaine response after cond. not corrected0.70.81.91.41.10.71.0-0.51.3-0.50.4-0.2-0.9-0.8
Cocaine response before conditioning1.72.03.71.21.01.51.2-1.90.6-1.81.8-1.61.00.9
Saline control response0.10.10.2-0.10.30.20.2-0.30.2-0.40.40.30.1-0.1
Bone: connectivity density2.84.39.3-3.0-2.4-2.2-2.12.1-2.11.9-1.92.5-0.4-0.4
Bone: cortical apparent density0.10.20.5-0.4-0.2-0.3-0.1-0.0-0.6-0.40.4-0.20.50.7
Bone: cortical area7.010.717.0-4.0-4.1-3.8-3.73.8-3.43.5-3.42.01.21.2
Bone: cortical porosity0.20.20.5-0.4-0.30.0-0.2-0.1-0.5-0.30.4-0.40.60.7
Bone: cortical porosity0.10.10.2-0.4-0.3-0.0-0.2-0.0-0.5-0.20.2-0.20.50.4
Bone: cortical thickness4.88.011.9-3.3-3.4-3.2-3.03.4-2.63.2-3.22.6-0.10.1
Bone: cortical thickness3.94.69.2-1.5-1.5-1.8-1.52.5-1.12.7-2.73.0-2.2-2.1
Bone: cortical tissue density0.10.10.5-0.2-0.0-0.10.1-0.2-0.4-0.50.5-0.30.40.7
Condit. Reinf. active minus inactive responses1.01.11.9-0.9-0.9-0.8-0.81.1-0.61.4-1.41.3-1.0-1.1
Condit. Reinf. active-inactive response ratio2.12.35.3-1.5-1.3-1.1-1.11.5-0.81.7-1.82.3-1.4-1.6
Condit. Reinf. active responses0.60.71.6-0.7-0.8-0.7-0.91.0-0.71.2-1.30.7-0.5-0.5
Condit. Reinf. inactive responses0.40.41.7-0.3-0.3-0.4-0.50.1-0.60.1-0.1-1.01.11.3
Incentive salience index mean0.70.81.5-1.0-1.0-0.9-1.01.0-1.11.2-1.20.2-0.1-0.2
Condit. Reinf. lever presses0.60.82.0-0.8-0.8-0.8-0.90.7-1.40.9-0.8-0.80.80.7
Condit. Reinf. active minus inactive responses0.10.10.30.20.20.40.3-0.40.4-0.60.60.3-0.2-0.3
Condit. Reinf. active-inactive response ratio0.20.20.4-0.4-0.5-0.6-0.40.6-0.30.5-0.50.3-0.20.3
Condit. Reinf. active responses1.21.63.01.31.31.51.4-1.61.2-1.71.7-0.60.2-0.3
Condit. Reinf. inactive responses3.34.37.02.32.22.42.1-2.51.8-2.62.6-1.60.8-0.1
Condit. Reinf. lever presses0.50.82.70.60.50.30.2-0.6-0.0-0.70.8-1.51.61.1
Condit. Reinf. lever reinforcers received0.50.71.40.90.80.90.8-1.00.6-1.21.2-0.70.70.2
Conditioned reinforcement - actives1.01.82.8-1.6-1.6-1.6-1.71.6-1.31.3-1.30.30.71.0
Conditioned reinforcement - inactives4.97.211.9-2.8-3.0-3.3-3.23.5-2.43.2-3.20.80.91.3
Conditioned locomotion0.70.91.6-0.8-0.9-1.3-1.21.2-0.91.1-1.10.00.50.8
Patch foraging indifference point 0 sec1.12.03.0-0.4-1.3-1.4-1.51.2-1.71.3-1.3-1.41.71.7
Patch foraging indifference point AUC0.40.61.90.70.40.20.4-0.5-0.4-0.60.6-1.41.21.1
Delay disc. indifference point, 0s delay3.03.35.62.42.22.12.1-2.21.6-1.81.8-1.4-0.7-0.6
Delay disc. indifference point, 16s delay0.60.61.21.00.70.90.7-1.10.5-0.90.9-1.00.10.0
Delay disc. indifference point, 2s delay0.30.40.50.70.70.70.6-0.70.5-0.40.4-0.4-0.7-0.6
Delay disc. indifference point, 24s delay0.30.41.90.70.30.30.2-0.4-0.1-0.20.2-1.40.80.7
Delay disc. indifference point, 4s delay0.00.00.2-0.00.10.10.0-0.3-0.1-0.10.1-0.50.10.2
Delay disc. indifference point, 8s delay0.10.20.80.3-0.0-0.1-0.20.1-0.50.3-0.3-0.90.40.7
Indifference point function ln k0.71.32.2-1.5-1.3-1.1-1.31.3-1.01.3-1.31.0-0.1-0.1
Indifference point function log k0.71.32.2-1.5-1.3-1.1-1.31.3-1.01.3-1.31.0-0.1-0.1
Patch foraging total patch changes 0 sec1.73.34.7-0.8-1.8-1.9-2.01.8-2.21.8-1.7-1.52.12.0
Patch foraging total patch changes 12 sec0.50.62.80.90.2-0.1-0.0-0.0-0.30.0-0.0-1.71.21.1
Patch foraging total patch changes 18 sec0.40.72.81.10.60.40.5-0.60.3-0.80.8-1.70.70.7
Patch foraging total patch changes 24 sec0.10.10.30.1-0.4-0.4-0.60.4-0.30.5-0.5-0.30.20.3
Patch foraging total patch changes 6 sec0.81.25.70.9-0.1-0.4-0.40.1-0.70.2-0.2-2.41.71.7
Patch foraging time to switch 0 sec0.91.83.31.21.41.61.4-1.81.3-1.81.8-0.6-0.3-0.3
Patch foraging water rate 0 sec0.71.52.9-0.9-1.3-1.4-1.31.4-1.71.5-1.5-0.20.90.7
Patch foraging water rate 12 sec0.91.93.4-1.8-1.8-1.4-1.61.4-1.51.4-1.41.10.10.2
Patch foraging water rate 18 sec0.30.51.6-1.3-0.8-0.5-0.80.4-1.20.5-0.50.40.1-0.0
Patch foraging water rate 24 sec1.41.94.2-2.0-1.6-1.3-1.61.2-1.81.4-1.41.20.0-0.2
Patch foraging water rate 6 sec1.31.82.7-1.4-1.5-1.5-1.61.6-1.51.6-1.60.50.60.4
Seeking ratio, delayed vs. immediate footshock1.51.93.01.61.71.51.7-1.71.0-1.61.6-1.00.20.1
Distance traveled before self-admin0.30.41.20.2-0.2-0.3-0.20.1-0.50.1-0.1-1.01.11.1
Distance traveled after self-admin0.50.61.3-0.5-0.7-0.8-0.70.7-0.90.5-0.5-0.51.20.9
Extensor digitorum longus weight0.10.31.40.60.2-0.20.10.2-0.20.3-0.3-1.20.90.6
Bone: elastic displacement0.10.20.30.10.20.50.3-0.50.3-0.30.30.6-0.5-0.5
Bone: elastic work1.41.93.1-1.5-1.8-1.6-1.51.5-1.41.5-1.50.90.40.7
Bone: endosteal estimation0.30.72.1-0.7-0.8-0.6-0.80.3-1.10.3-0.3-0.91.51.1
Bone: endosteal perimeter0.91.93.0-1.6-1.7-1.5-1.71.5-1.41.3-1.30.11.21.1
Epididymis fat weight1.86.211.8-3.4-3.1-2.6-2.72.0-3.41.6-1.60.22.62.3
Delta time in closed arm before/after self-admin0.20.21.40.20.0-0.2-0.20.1-0.60.2-0.2-1.20.50.3
Delta time in open arm before/after self-admin0.20.20.6-0.10.10.40.4-0.70.3-0.80.80.30.0-0.2
Diff in mean of infusions in LGA sessions1.01.24.60.2-0.4-0.5-0.4-0.1-0.7-0.20.2-2.11.92.0
Delay discount exponential model param0.00.00.2-0.10.0-0.00.20.00.2-0.20.20.40.0-0.1
Extinction: sum of active levers before priming0.10.10.3-0.5-0.30.10.1-0.3-0.6-0.40.40.40.10.2
Active lever presses in extinction session 60.30.30.50.60.50.60.6-0.70.6-0.70.7-0.40.20.1
Bone: final force6.810.816.0-3.4-4.0-3.9-3.83.8-3.93.6-3.60.31.91.8
Bone: final moment6.410.415.4-3.3-3.9-3.8-3.73.7-3.73.6-3.50.41.81.7
Food consumed during 24 hour testing period0.10.10.5-0.2-0.10.30.1-0.2-0.1-0.30.30.3-0.4-0.7
Glucose1.11.73.7-0.8-1.3-1.3-1.31.1-1.70.9-0.8-1.01.91.8
Heart weight1.01.53.3-0.7-0.7-0.9-0.91.6-0.11.8-1.81.5-1.1-1.3
Delay discount hyperbolic model param0.00.00.2-0.3-0.1-0.10.10.10.1-0.20.20.50.1-0.0
Intermittent access intake day 1-15 change0.71.43.9-1.7-1.2-1.1-1.21.2-0.61.0-1.02.0-0.4-0.4
Intermittent access intake escalation0.61.24.8-1.6-1.0-0.9-1.01.0-0.50.9-0.92.2-0.7-0.5
Intermittent access intake escalation 21.21.43.2-1.8-1.4-1.3-1.41.1-1.30.9-0.91.00.60.5
Intermitt. access day 1 inactive lever presses0.00.10.2-0.3-0.2-0.3-0.30.40.30.2-0.30.40.00.3
Intermitt. access day 15 inactive lever presses0.10.20.90.30.50.30.3-0.00.9-0.20.20.5-0.6-0.5
Intermitt. access escalation Index0.40.50.80.80.90.90.9-0.80.7-0.50.5-0.0-0.7-0.6
Intermittent access day 1 total infusions0.20.41.50.3-0.1-0.5-0.30.4-0.30.4-0.4-1.20.81.0
Intermittent access day 15 total infusions0.71.01.8-1.3-1.0-1.1-1.01.2-0.71.0-1.01.3-0.30.0
Intermittent access terminal intake (last 3 days)0.70.91.6-1.3-1.0-1.1-1.11.2-0.90.9-0.90.70.10.2
Intermittent access total infusions1.01.22.0-1.1-1.2-1.4-1.31.4-1.11.2-1.1-0.00.60.8
Intermittent access day 1 locomotion1.11.42.3-0.7-1.1-1.3-1.31.2-1.31.0-0.9-0.91.31.5
Intermittent access day 15 total locomotion0.40.71.3-1.2-0.9-1.0-1.01.0-0.90.8-0.80.50.10.3
Intermittent access total locomotion1.51.82.8-1.3-1.4-1.7-1.61.6-1.51.3-1.3-0.21.01.2
Intermittent access standard deviation0.10.20.4-0.6-0.5-0.6-0.60.6-0.50.4-0.40.30.40.4
Left kidney weight0.41.84.3-0.9-1.1-1.3-1.10.8-1.50.5-0.5-1.62.12.0
Right kidney weight1.46.512.4-2.5-2.6-2.6-2.61.9-3.21.3-1.3-1.73.53.5
Cocaine induced anxiety0.40.62.40.5-0.2-0.4-0.30.1-0.20.0-0.0-1.61.31.3
Post-drug Anxiety0.30.40.90.80.40.50.5-0.60.5-0.60.6-0.90.50.5
Baseline Anxiety1.01.21.80.71.11.31.3-1.20.9-1.01.00.7-1.1-1.2
Tail length0.72.74.2-1.6-1.7-1.9-1.81.6-2.01.6-1.6-0.31.71.5
Length with tail2.08.612.2-3.3-3.2-3.5-3.43.3-3.53.1-3.00.42.11.8
Length without tail2.27.010.8-3.2-3.0-3.1-2.93.3-2.63.1-3.01.80.30.1
Times rat made contact with spout0.00.10.3-0.30.0-0.00.10.0-0.3-0.00.0-0.2-0.5-0.2
Lifetime Intake1.41.82.8-1.3-1.5-1.7-1.61.7-1.31.5-1.50.00.71.0
Liver weight, left0.10.10.4-0.5-0.00.10.3-0.2-0.3-0.50.50.60.1-0.1
Liver weight, right2.64.57.8-2.8-2.4-2.3-2.41.8-2.81.2-1.2-0.42.42.2
Locomotor activity0.40.72.2-1.5-1.0-0.8-0.70.6-1.40.6-0.60.50.20.0
Locomotor testing distance0.20.31.1-0.8-0.40.0-0.10.1-0.40.2-0.21.0-0.7-0.8
Locomotor testing rearing0.00.10.2-0.4-0.20.30.1-0.4-0.5-0.40.40.20.10.1
Locomotion in novel chamber0.40.51.5-0.9-0.9-0.7-0.70.6-1.20.6-0.60.30.20.2
Locomotion in novel chamber post-restriction1.93.17.1-2.5-1.9-1.5-1.61.6-1.71.6-1.62.7-0.8-0.8
Fecal boli incidents, locomotor time 10.10.10.4-0.5-0.3-0.2-0.2-0.1-0.4-0.10.10.10.10.6
Change in fecal boli incidents, locomotor task1.61.53.21.81.61.21.3-1.21.1-1.11.1-1.70.3-0.2
Time >=10cm from walls, locomotor time 10.30.31.00.10.2-0.10.2-0.2-0.5-0.40.4-0.80.91.0
Bouts of movement, locomotor time 10.20.20.4-0.50.00.1-0.0-0.2-0.5-0.50.6-0.40.60.6
Total resting periods, locomotor time 10.20.20.7-0.30.20.40.2-0.5-0.2-0.80.8-0.30.30.3
Rest time, locomotor task time 10.30.40.80.90.80.70.5-0.60.6-0.40.4-0.80.1-0.2
Distance moved, locomotor task time 10.10.10.30.50.30.30.5-0.30.4-0.40.4-0.10.00.2
Vertical activity count, locomotor time 10.00.10.4-0.6-0.3-0.3-0.10.1-0.40.0-0.00.40.20.2
Time >=10cm from walls, locomotor time 20.71.12.00.91.11.01.1-0.91.2-0.60.61.0-1.3-1.4
Bouts of movement, locomotor time 20.20.40.80.90.70.70.6-0.50.8-0.50.5-0.3-0.4-0.4
Total resting periods, locomotor time 20.20.30.70.90.60.60.5-0.40.7-0.40.4-0.5-0.3-0.2
Rest time, locomotor task time 20.20.20.90.2-0.2-0.3-0.30.4-0.30.5-0.4-0.90.50.5
Distance moved, locomotor task time 20.20.21.10.10.30.30.4-0.30.7-0.30.31.0-0.6-0.3
Vertical activity count, locomotor time 20.50.63.5-0.10.20.10.30.00.70.2-0.31.9-1.2-1.1
Light reinforcement 10.10.31.50.3-0.2-0.0-0.1-0.1-0.4-0.10.2-1.20.90.6
Light reinforcement 20.40.63.00.90.2-0.00.2-0.2-0.1-0.20.3-1.71.11.0
Bone: marrow area0.30.61.8-0.6-0.7-0.5-0.70.2-1.00.3-0.3-0.91.41.0
Bone: maximum diameter2.24.16.6-2.2-2.6-2.3-2.32.4-1.92.4-2.41.20.70.8
Bone: maximum force6.912.318.4-4.0-4.3-4.1-4.03.9-4.13.7-3.70.81.81.8
Bone: maximum moment6.210.916.5-3.8-4.1-3.9-3.83.7-3.83.5-3.50.81.61.6
Mean time between licks in bursts1.12.74.0-1.6-1.9-1.8-1.91.7-2.01.7-1.6-0.41.51.4
Mean num. licks in bursts0.40.72.0-1.4-1.0-0.9-0.90.9-0.80.6-0.50.9-0.3-0.0
Cd content in liver4.55.08.8-2.3-2.1-2.2-2.12.7-1.72.7-2.83.0-0.9-1.3
Co content in liver0.10.10.30.40.20.30.2-0.10.30.1-0.10.5-0.5-0.5
Cu content in liver1.01.23.00.70.91.01.2-0.91.1-0.70.60.9-1.7-1.6
Fe content in liver0.50.61.00.71.00.71.0-0.80.7-0.90.9-0.2-0.3-0.5
K content in liver2.82.74.82.21.91.92.0-1.82.0-1.51.5-0.3-1.1-0.9
Mg content in liver0.30.30.80.80.50.50.7-0.40.9-0.30.30.5-0.6-0.5
Mn content in liver0.10.10.30.40.30.20.2-0.10.5-0.10.10.50.0-0.2
Na content in liver1.81.93.81.21.51.51.7-1.91.2-1.91.9-0.3-0.4-0.1
Rb content in liver1.21.43.2-0.4-0.9-1.1-0.91.6-0.11.8-1.81.2-1.1-1.1
Se content in liver0.40.40.90.40.50.60.7-0.50.9-0.50.51.0-0.8-0.8
Sr content in liver0.20.20.6-0.7-0.3-0.1-0.2-0.1-0.5-0.50.50.10.70.8
Zn content in liver0.10.10.30.20.10.20.2-0.40.2-0.50.5-0.20.50.4
Bone: minimum diameter3.05.58.9-3.0-2.9-2.6-2.62.3-3.01.9-1.80.42.12.0
Time in familiar zone, hab. session 10.50.50.9-0.9-0.7-0.7-0.90.4-0.90.2-0.2-0.50.90.9
Time in novel zone, hab. session 10.60.62.80.40.30.20.40.20.40.5-0.61.0-1.1-1.7
Total zone transitions, hab. session 10.10.20.4-0.30.10.30.0-0.6-0.3-0.60.6-0.50.50.3
Total locomotion distance, hab. session 10.20.20.7-0.6-0.10.50.1-0.8-0.2-0.70.70.0-0.1-0.2
Locomotion velocity, hab. session 10.30.41.1-0.30.10.70.3-1.1-0.0-1.01.1-0.50.30.2
Time in familiar zone, hab. session 20.10.10.5-0.3-0.2-0.2-0.30.1-0.2-0.10.0-0.40.70.4
Time in novel zone, hab. session 20.20.30.7-0.3-0.3-0.3-0.20.5-0.10.5-0.50.8-0.7-0.8
Total zone transitions, hab. session 20.00.10.1-0.00.30.30.1-0.10.2-0.20.20.1-0.2-0.4
Total locomotion distance, hab. session 20.30.41.5-0.50.00.1-0.10.20.20.1-0.21.1-1.0-1.2
Locomotion velocity, hab. session 20.20.20.9-0.40.20.30.1-0.10.2-0.10.10.8-0.8-1.0
Novel to familiar place preference ratio0.70.71.6-1.3-1.0-1.1-1.00.8-1.10.7-0.70.10.50.6
Novelty place preference0.40.40.9-1.0-0.8-0.8-0.80.6-0.70.5-0.50.00.30.4
Time in novel zone, NPP test0.20.30.8-0.9-0.6-0.6-0.60.4-0.70.3-0.3-0.10.30.2
Total zone transitions, NPP test0.30.40.70.40.70.80.7-0.70.3-0.60.60.3-0.6-0.8
Total locomotion distance, NPP test0.60.82.00.20.71.00.9-1.00.7-0.60.60.7-1.3-1.4
Locomotion velocity, NPP test0.50.71.30.30.81.10.9-1.10.7-0.80.80.4-1.1-0.9
Intraocular pressure0.60.92.2-0.7-0.8-1.2-0.91.3-0.41.5-1.50.6-0.3-0.2
Delta distance traveled before/after self-admin0.80.81.5-1.2-1.1-1.1-1.00.9-1.10.6-0.6-0.20.80.7
Delta ambulatory time before/after self-admin0.20.20.4-0.7-0.6-0.6-0.50.6-0.40.4-0.40.20.20.3
Parametrial fat weight2.45.69.8-2.0-2.4-2.6-2.62.1-2.81.8-1.8-1.53.12.9
Pavlov. Cond. lever latency0.10.10.40.30.40.30.2-0.10.6-0.20.20.2-0.1-0.3
Pavlov. Cond. magazine entry latency0.30.40.8-0.7-0.8-0.7-0.80.5-0.90.5-0.5-0.30.60.4
Pavlov. Cond. change in total contacts0.50.61.2-0.3-0.8-0.8-0.80.8-1.11.0-1.0-0.50.40.3
Pavlov. Cond. index score0.10.10.5-0.3-0.4-0.2-0.2-0.1-0.70.00.0-0.50.50.5
Pavlov. Cond. latency score0.10.10.50.2-0.00.10.1-0.3-0.4-0.20.2-0.70.30.3
Pavlov. Cond. lever contacts0.20.20.6-0.4-0.5-0.4-0.30.1-0.80.2-0.1-0.70.60.8
Pavlov. Cond. magazine entry number0.30.40.90.60.90.70.7-0.51.0-0.40.40.4-0.8-0.6
Pavlov. Cond. intertrial magazine entries1.51.76.6-0.30.10.00.10.50.70.9-1.02.4-2.6-2.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.1-0.3-0.1-0.1-0.1-0.5-0.00.1-0.50.50.5
Pavlov. Cond. response bias0.40.41.1-0.8-0.9-0.7-0.70.5-1.00.5-0.5-0.20.50.5
Pavlov. Cond. lever latency0.70.93.8-0.30.00.40.30.00.50.1-0.21.8-2.0-1.6
Pavlov. Cond. magazine entry latency0.30.41.2-0.0-0.2-0.6-0.30.3-0.50.1-0.1-0.81.11.1
Pavlov. Cond. change in total contacts0.40.62.60.70.2-0.2-0.1-0.1-0.2-0.10.1-1.61.51.1
Pavlov. Cond. index score0.60.83.10.4-0.0-0.6-0.30.2-0.50.1-0.1-1.61.81.5
Pavlov. Cond. latency score0.40.62.10.60.2-0.3-0.1-0.1-0.1-0.10.2-1.51.41.2
Pavlov. Cond. lever contacts0.60.83.20.60.3-0.20.0-0.2-0.2-0.30.3-1.81.71.4
Pavlov. Cond. magazine entry number1.01.23.70.30.61.10.9-0.71.1-0.50.41.3-1.9-1.8
Pavlov. Cond. intertrial magazine entries0.20.30.6-0.00.40.80.5-0.60.2-0.60.60.4-0.4-0.6
Pavlov. Cond. lever-magazine prob. diff.0.60.93.20.3-0.1-0.7-0.40.3-0.60.2-0.2-1.61.81.6
Pavlov. Cond. response bias0.81.14.30.2-0.2-0.6-0.40.2-0.70.00.0-1.72.11.8
Time in closed arm before self-admin1.01.34.10.2-0.7-0.9-0.90.8-0.30.8-0.8-1.71.62.0
Time in closed arm after self-admin1.01.01.50.0-0.8-1.1-1.01.1-0.61.2-1.2-1.21.21.1
Time in open arm before self-admin0.10.10.3-0.30.30.20.3-0.2-0.2-0.30.30.6-0.6-0.6
Time in open arm after self-admin0.70.73.4-0.60.20.60.4-0.50.2-0.60.61.8-1.0-1.3
Bone: periosteal estimation2.45.28.3-2.8-2.9-2.6-2.72.4-2.62.2-2.20.71.51.3
Bone: periosteal perimeter3.96.710.9-2.9-3.3-3.0-3.13.1-2.42.9-2.81.11.21.2
Bone: post-yield work0.30.41.2-1.1-0.7-0.6-0.50.6-0.60.6-0.60.7-0.4-0.4
Progressive ratio test 1 active lever presses1.01.21.9-0.4-1.0-1.2-1.21.2-1.11.1-1.1-1.21.11.4
Progressive ratio test 1 breakpoint0.91.11.6-0.4-0.9-1.2-1.11.1-1.01.1-1.0-1.11.01.3
Progressive ratio test 1 inactive lever presses0.40.61.1-0.8-1.0-1.0-0.91.0-0.50.7-0.7-0.00.51.0
Progressive ratio test 2 active lever presses0.50.60.9-0.7-0.8-1.0-0.91.0-0.80.8-0.8-0.20.50.9
Progressive ratio test 2 breakpoint0.40.40.7-0.6-0.7-0.8-0.80.8-0.60.7-0.7-0.20.40.8
Progressive ratio test 2 inactive lever presses0.50.81.8-0.7-1.0-1.1-1.11.3-0.51.3-1.30.1-0.00.3
Incentive Sensitization - Responses0.10.10.1-0.4-0.3-0.3-0.30.3-0.30.3-0.20.10.00.2
Incentive Sensitization - Breakpoint0.00.00.1-0.4-0.3-0.2-0.20.2-0.20.1-0.10.1-0.00.1
Sum of active levers in priming session hrs 5-61.71.66.4-0.30.30.80.7-0.40.8-0.30.32.5-2.0-2.1
Progressive ratio0.10.10.3-0.3-0.3-0.1-0.30.20.10.2-0.20.5-0.2-0.4
Food seeking constrained by brief footshock1.72.08.8-1.0-0.6-0.3-0.40.90.31.1-1.23.0-2.0-2.1
Seeking ratio, punishment vs. effort0.40.52.4-0.4-0.00.10.20.20.10.4-0.41.6-1.2-1.2
Retroperitoneal fat weight2.410.414.5-3.5-3.8-3.7-3.83.3-3.83.3-3.20.22.62.3
Reaction time number correct0.20.51.7-1.3-1.0-0.2-0.6-0.1-0.9-0.20.30.60.50.5
Reaction time mean minus median0.20.41.70.70.70.20.4-0.50.1-0.50.5-1.30.80.7
Reaction time mean minus median AUC0.20.41.50.80.80.30.3-0.40.4-0.40.4-1.20.60.6
Reaction time num false alarms0.20.30.7-0.1-0.8-0.7-0.60.7-0.10.7-0.70.20.40.3
Reaction time num false alarms AUC0.10.20.40.1-0.6-0.5-0.40.60.10.6-0.60.20.20.1
Reaction time trials correct on left0.20.51.7-1.3-1.0-0.2-0.6-0.1-0.9-0.20.30.60.50.5
Reaction time trials on left0.30.51.9-1.4-1.1-0.3-0.70.0-1.0-0.20.20.60.70.7
Reaction time mean0.40.62.2-0.1-0.3-0.8-0.60.6-0.50.4-0.4-1.01.51.3
Reaction time mean AUC0.40.62.30.50.3-0.20.0-0.1-0.0-0.30.3-1.51.51.3
Median of all reaction times0.40.51.4-0.2-0.5-0.8-0.60.8-0.40.6-0.6-0.51.21.1
Reaction time omissions1.11.65.0-0.4-0.8-1.1-0.90.7-1.40.5-0.4-1.62.22.1
Reaction time false alarm rate0.20.31.10.4-0.3-0.6-0.30.90.11.0-1.00.1-0.1-0.3
Reaction time premature initiation rate0.10.20.50.20.50.50.3-0.30.2-0.20.2-0.1-0.7-0.7
Reaction time premature initiations0.00.10.2-0.5-0.10.2-0.1-0.3-0.4-0.30.3-0.0-0.00.0
Std. dev. reaction times0.40.72.3-0.2-0.1-0.7-0.50.4-0.80.2-0.2-1.21.51.3
Reaction time trials completed0.30.51.9-1.4-1.1-0.3-0.70.0-1.0-0.20.20.60.70.7
Reaction time trials AUC0.40.72.4-1.5-1.3-0.5-0.90.2-1.1-0.10.10.60.70.8
Run reversals in cocaine runway, females2.32.33.7-1.4-1.7-1.7-1.91.9-1.61.7-1.7-0.11.11.0
Run reversals in cocaine runway, males0.90.91.70.91.01.11.3-1.11.0-1.21.2-0.2-0.5-0.4
Latency to leave start box in cocaine runway0.10.10.4-0.3-0.1-0.2-0.30.1-0.70.00.0-0.50.60.5
Latency to leave start box in cocaine runway, F0.40.51.1-0.8-0.6-0.7-0.80.8-1.10.7-0.6-0.20.50.3
Latency to leave start box in cocaine runway, M0.50.50.80.80.80.80.8-0.90.5-0.90.9-0.70.20.3
Std. dev. time between licks in bursts1.92.53.8-1.6-1.9-1.7-1.91.8-1.91.8-1.80.20.90.6
Total sessions with >9 infusions2.32.74.5-1.4-1.8-2.0-2.12.1-1.51.9-1.90.00.91.3
Short access day 1 total inactive lever presses0.91.22.5-1.0-1.1-1.2-1.21.6-0.61.5-1.50.7-0.20.2
Short access day 10 total inactive lever presses1.23.05.82.41.91.91.9-1.82.1-1.71.7-1.60.00.1
Short access day 1 total infusions3.14.16.3-2.3-2.4-2.4-2.42.5-2.02.4-2.30.80.51.0
Short access day 10 total infusions0.70.91.6-0.9-0.9-1.1-1.11.2-0.81.3-1.30.50.00.1
Short access total infusions1.31.72.7-1.2-1.5-1.6-1.61.6-1.31.5-1.5-0.20.71.0
Short access day 1 locomotion3.34.16.7-1.8-2.2-2.5-2.42.6-1.82.5-2.50.51.01.2
Short access day 10 total locomotion1.42.74.2-2.0-1.9-1.8-1.92.0-1.71.7-1.71.30.30.4
Short access total locomotion2.42.95.1-1.7-1.9-2.0-2.02.3-1.72.1-2.10.80.50.5
One hour access (0.3 mA shock)0.80.92.0-0.6-0.8-0.8-0.71.1-0.31.4-1.41.2-0.8-0.6
Compulsive drug intake0.70.91.31.01.01.11.1-0.91.2-0.70.70.3-0.9-1.0
One hour access (shock baseline)1.32.03.1-1.3-1.6-1.7-1.71.8-1.31.7-1.70.50.50.8
Social response proportion4.34.97.9-2.2-2.5-2.2-2.22.6-1.42.8-2.82.4-1.2-1.2
Social responses1.62.14.5-1.7-1.5-1.1-1.21.3-0.91.6-1.62.1-1.3-1.3
Social time0.40.51.80.60.40.20.30.30.70.6-0.60.8-1.3-1.2
Soleus weight0.72.14.3-0.8-1.2-1.5-1.41.2-1.71.2-1.2-1.22.11.9
Bone: stiffness4.06.59.5-2.7-3.0-3.0-3.03.1-2.92.8-2.70.01.51.4
Tibialis anterior weight0.20.61.6-1.1-0.7-0.8-0.70.7-1.20.4-0.4-0.20.80.6
Time to tail flick, vehicle, before self-admin0.50.51.1-1.1-0.9-0.7-0.90.8-0.50.6-0.50.60.1-0.2
Time to tail flick, vehicle, after self-admin0.20.31.10.20.10.1-0.0-0.4-0.0-0.50.5-1.01.00.8
Time to tail flick, test, before self-admin0.70.71.9-0.2-0.8-0.9-0.71.2-0.21.3-1.40.8-0.00.1
Time to tail flick, test, after self-admin0.30.30.90.30.50.40.3-0.20.7-0.10.10.9-0.9-0.9
Delta time to tail flick, vehicle, before/after SA0.80.71.11.11.11.00.9-1.10.7-0.90.9-0.90.20.2
Delta time to tail flick, test, before/after SA0.10.20.3-0.40.10.30.1-0.5-0.2-0.50.50.4-0.3-0.5
Tibia length0.41.11.8-1.0-1.2-1.3-1.21.3-1.01.4-1.3-0.10.30.4
Ambulatory time before self-admin0.50.82.60.2-0.2-0.3-0.20.0-0.70.0-0.0-1.61.61.6
Ambulatory time after self-admin1.11.22.4-0.9-1.1-1.2-1.00.9-1.40.7-0.7-0.81.51.6
Bone: tissue strength0.70.72.7-0.1-0.2-0.2-0.3-0.1-0.6-0.40.4-1.51.61.4
Total heroin consumption0.30.41.3-0.0-0.3-0.3-0.2-0.1-0.5-0.10.1-1.21.11.0
Bone: trabecular number3.25.210.2-3.2-2.7-2.5-2.32.3-2.52.3-2.32.5-0.3-0.1
Bone: trabecular spacing0.50.71.41.00.80.90.7-0.90.8-0.90.9-1.20.40.5
Bone: trabecular thickness2.43.05.0-2.2-1.9-1.9-1.71.9-1.71.9-1.91.9-0.7-0.5
Bone: trabecular tissue density0.20.30.8-0.3-0.00.20.2-0.6-0.2-0.90.9-0.60.60.9
Water consumed over 24 hours0.40.61.4-1.2-1.0-0.7-0.80.7-1.20.6-0.60.4-0.1-0.2
Number of responses in last shaping day1.11.21.9-1.2-1.0-1.0-1.01.3-0.91.4-1.41.3-0.6-0.5