Hub : Genes

Coch

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Coch 0.24 0.14 2.5e-04 0.13 0.09 0.04 0.07 6.3e-04 4.3e-03 4.0e-02 1.1e-02
2 NAcc gene expression Coch 0.19 0.09 0.0e+00 0.16 0.16 0.16 0.16 1.8e-18 3.2e-18 3.7e-18 2.3e-18
3 Eye gene expression Coch 0.34 0.17 3.3e-03 0.07 0.06 0.07 0.06 3.3e-02 4.0e-02 3.1e-02 5.0e-02
4 NAcc mRNA stability Coch 0.07 0.05 1.7e-05 0.04 0.03 0.05 0.05 2.5e-05 2.0e-04 4.5e-06 8.7e-07
5 Liver isoform ratio XM_017594223.2 0.03 0.03 2.7e-03 0.01 0.01 0.02 0.01 3.9e-02 1.3e-02 5.8e-03 2.7e-02
6 PL gene expression Coch 0.2 0.09 0.0e+00 0.19 0.18 0.18 0.19 3.5e-20 1.0e-19 2.1e-19 1.9e-20
7 LHb gene expression Coch 0.15 0.1 4.3e-03 0.06 0.08 0.07 0.05 1.3e-02 6.7e-03 1.1e-02 2.9e-02
8 Liver isoform ratio NM_001108710.2 0.03 0.03 1.6e-03 0.01 0.01 0.02 0.01 1.8e-02 6.8e-03 3.2e-03 1.1e-02
9 OFC gene expression Coch 0.25 0.14 3.9e-04 0.13 0.08 0.06 0.08 6.3e-04 5.1e-03 1.5e-02 7.1e-03
10 pVTA gene expression Coch 0.23 0.11 2.3e-07 0.07 0.12 0.13 0.12 4.9e-04 1.1e-05 2.9e-06 5.7e-06
11 Brain gene expression Coch 0.59 0.12 0.0e+00 0.48 0.57 0.57 0.57 7.7e-51 1.1e-63 3.2e-64 9.6e-64
12 Brain isoform ratio NM_001108710.2 0.07 0.05 1.3e-04 0.01 0.03 0.03 0.02 6.3e-02 7.8e-04 6.9e-04 4.5e-03
13 Brain isoform ratio XM_017594223.2 0.07 0.05 1.3e-04 0.01 0.03 0.03 0.02 7.0e-02 8.6e-04 7.8e-04 5.2e-03
14 Liver gene expression Coch 0.48 0.13 0.0e+00 0.45 0.46 0.46 0.46 4.4e-55 5.8e-56 1.8e-56 2.0e-56
15 BLA gene expression Coch 0.35 0.13 5.6e-17 0.3 0.28 0.26 0.29 1.3e-16 4.0e-15 1.9e-14 3.8e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.62.75.12.22.22.20.02.1-2.1-2.0-2.00.91.81.8-0.40.21.00.9
Area under the delay curve1.61.74.1-0.2-0.1-0.2-1.8-0.90.80.81.1-1.4-1.1-1.1-2.02.0-1.8-1.9
BMI with tail0.51.64.30.20.20.22.10.7-0.7-0.8-1.02.11.01.11.6-1.71.71.6
BMI without tail2.04.25.91.71.71.81.62.2-2.3-2.3-2.22.22.22.41.5-1.72.32.2
Body weight2.29.116.04.03.93.80.33.3-4.0-3.9-3.11.93.63.7-0.2-0.12.12.1
Weight adjusted by age0.30.31.7-0.4-0.4-0.21.3-0.00.20.1-0.21.10.00.10.7-0.70.60.3
Bone surface0.71.23.21.31.31.2-1.60.5-0.7-0.6-0.2-1.00.40.3-1.81.7-0.9-0.8
Bone volume1.01.63.61.91.91.9-0.91.4-1.4-1.3-1.1-0.11.11.0-1.41.3-0.2-0.2
Breakpoint value in progressive ratio session1.41.63.21.81.81.8-0.41.4-1.5-1.4-1.30.41.41.1-1.21.10.20.0
Number of licking bursts0.00.00.1-0.2-0.2-0.20.3-0.20.10.10.10.1-0.1-0.00.3-0.30.20.1
Context. condit. distance diff. score0.81.03.00.20.20.71.61.3-0.6-0.7-1.41.70.50.70.9-0.91.20.9
Locomotion velocity, session 10.10.10.40.00.00.2-0.70.10.10.1-0.0-0.5-0.2-0.2-0.40.4-0.4-0.4
Locomotion distance, session 10.91.12.6-1.6-1.6-1.50.2-1.21.31.31.1-0.4-1.1-1.00.9-0.8-0.2-0.1
Locomotion velocity, session 22.63.04.4-1.9-1.9-2.0-1.0-2.12.12.12.1-1.5-2.0-2.0-0.50.6-1.6-1.4
Locomotion distance, session 22.13.06.3-2.2-2.2-2.5-0.3-2.42.02.12.2-1.1-1.9-1.80.5-0.4-0.9-0.7
Locomotion velocity, session 32.42.84.2-1.9-1.9-2.0-1.1-2.01.82.02.1-1.9-1.9-1.8-0.00.2-1.4-1.2
Locomotion distance, session 30.40.51.6-0.7-0.7-1.00.3-0.80.20.40.7-0.3-0.2-0.01.2-1.20.40.6
Stereotopy head waving bouts, day 32.12.54.1-2.0-2.0-1.6-0.6-1.52.02.01.5-1.0-1.9-2.0-0.50.6-1.4-1.6
Stereotopy head waving duration, day 31.92.33.4-1.6-1.6-1.3-1.1-1.51.81.81.5-1.3-1.7-1.9-0.80.9-1.6-1.6
Locomotion velocity, session 72.12.38.3-0.5-0.5-0.62.10.3-0.3-0.4-0.61.60.70.92.9-2.82.02.2
Locomotion distance, session 72.63.47.90.40.40.12.41.0-1.2-1.2-1.22.11.51.72.8-2.82.52.6
Stereotopy head waving bouts, day 70.70.81.9-0.3-0.30.1-1.4-0.20.60.60.4-1.3-0.7-0.8-1.21.2-1.2-1.2
Stereotopy head waving duration, day 71.62.03.4-1.1-1.1-0.8-1.7-1.11.51.41.2-1.8-1.5-1.6-1.21.3-1.7-1.7
Locomotion velocity, session 80.30.40.8-0.5-0.5-0.2-0.8-0.30.60.60.4-0.7-0.9-0.8-0.60.6-0.8-0.9
Locomotion distance, session 80.20.30.9-0.9-0.9-0.80.4-0.50.60.60.40.1-0.7-0.50.6-0.60.1-0.0
Degree of sensitization distance0.70.71.30.80.80.80.91.0-0.8-0.9-1.11.20.90.80.3-0.30.80.7
Degree of sensitization stereotypy0.40.41.40.50.50.7-1.20.4-0.2-0.2-0.2-0.90.1-0.1-1.01.0-0.7-0.7
Conditioned locomotion1.51.82.8-1.5-1.5-1.3-1.0-1.31.51.51.4-1.4-1.7-1.6-0.60.7-1.3-1.3
Cocaine response after cond. corrected0.20.20.5-0.0-0.0-0.10.60.1-0.2-0.2-0.20.50.40.30.7-0.70.60.6
Cocaine response after cond. not corrected1.01.11.70.70.70.60.90.9-1.0-1.0-1.01.01.21.21.2-1.21.31.3
Cocaine response before conditioning0.81.01.60.90.90.90.51.0-1.2-1.2-1.00.71.21.30.9-0.91.21.1
Saline control response0.81.02.61.41.41.6-0.11.3-1.2-1.2-1.20.60.90.9-0.80.70.2-0.1
Bone: connectivity density3.04.78.93.03.02.9-0.32.5-2.8-2.7-2.30.72.62.5-0.30.11.31.4
Bone: cortical apparent density1.41.85.00.10.10.32.21.0-0.5-0.8-1.32.11.01.01.7-1.71.81.7
Bone: cortical area1.11.75.51.31.30.9-2.0-0.2-0.5-0.30.5-1.50.1-0.0-2.32.3-1.4-1.3
Bone: cortical porosity1.21.32.7-0.2-0.2-0.4-1.6-0.90.70.81.1-1.6-1.0-0.9-1.41.4-1.5-1.5
Bone: cortical porosity1.71.83.8-0.3-0.3-0.5-2.0-1.20.81.01.4-1.9-1.1-1.1-1.61.6-1.8-1.7
Bone: cortical thickness0.20.30.80.90.90.6-0.10.3-0.8-0.6-0.20.00.60.6-0.40.40.10.2
Bone: cortical thickness0.00.00.1-0.2-0.2-0.20.4-0.2-0.10.10.10.2-0.1-0.10.0-0.00.00.0
Bone: cortical tissue density1.41.85.20.10.10.32.31.0-0.5-0.8-1.32.10.91.01.7-1.71.81.7
Condit. Reinf. active minus inactive responses1.11.23.61.51.50.9-1.90.1-1.0-0.80.2-1.40.80.6-1.41.3-0.7-0.4
Condit. Reinf. active-inactive response ratio0.10.20.30.60.60.4-0.50.1-0.5-0.4-0.0-0.40.50.4-0.30.3-0.10.0
Condit. Reinf. active responses1.61.97.21.41.40.9-2.7-0.2-0.9-0.50.6-2.20.40.3-2.01.9-1.3-1.0
Condit. Reinf. inactive responses0.70.83.50.50.50.2-1.9-0.5-0.10.00.7-1.7-0.3-0.2-1.21.1-1.0-0.8
Incentive salience index mean1.72.07.91.31.30.5-2.8-0.6-0.7-0.31.0-2.50.30.1-2.01.9-1.4-1.1
Condit. Reinf. lever presses0.70.93.80.30.3-0.3-1.9-1.0-0.10.31.2-2.0-0.2-0.3-1.11.0-1.1-0.7
Condit. Reinf. active minus inactive responses0.10.10.2-0.3-0.3-0.3-0.3-0.30.20.20.3-0.5-0.2-0.20.1-0.0-0.2-0.2
Condit. Reinf. active-inactive response ratio0.40.40.5-0.7-0.7-0.6-0.4-0.60.70.70.7-0.7-0.7-0.7-0.10.2-0.6-0.6
Condit. Reinf. active responses0.10.20.5-0.4-0.4-0.4-0.5-0.40.30.40.5-0.7-0.4-0.30.1-0.1-0.3-0.3
Condit. Reinf. inactive responses0.20.30.40.40.40.50.30.6-0.5-0.6-0.60.30.60.60.5-0.50.60.5
Condit. Reinf. lever presses0.50.72.11.01.01.2-1.40.8-0.7-0.7-0.5-1.00.50.4-1.00.9-0.4-0.3
Condit. Reinf. lever reinforcers received0.30.51.90.20.20.2-1.4-0.2-0.00.10.4-1.3-0.2-0.3-0.90.8-0.8-0.8
Conditioned reinforcement - actives1.71.75.00.20.3-0.0-2.2-0.80.40.51.1-2.0-0.7-0.8-1.91.9-1.7-1.5
Conditioned reinforcement - inactives0.50.61.31.00.91.1-1.10.9-0.5-0.7-0.7-0.60.50.5-0.90.8-0.2-0.2
Conditioned locomotion0.40.51.3-0.2-0.1-0.4-1.1-0.80.40.50.9-1.1-0.7-0.6-0.70.7-0.9-0.7
Patch foraging indifference point 0 sec1.32.17.31.41.40.8-2.7-0.1-0.6-0.30.5-2.10.2-0.0-2.22.1-1.5-1.3
Patch foraging indifference point AUC3.13.612.10.00.0-0.4-3.5-1.50.61.01.9-3.5-1.0-1.2-2.22.2-2.4-2.0
Delay disc. indifference point, 0s delay0.30.41.60.40.30.7-0.40.50.2-0.0-0.40.0-0.1-0.3-1.31.3-0.6-0.8
Delay disc. indifference point, 16s delay1.61.63.4-0.6-0.4-0.5-1.3-1.11.11.01.2-1.0-1.3-1.3-1.71.8-1.7-1.8
Delay disc. indifference point, 2s delay0.30.41.40.40.40.4-1.2-0.0-0.0-0.00.2-0.9-0.0-0.1-1.00.9-0.7-0.6
Delay disc. indifference point, 24s delay2.22.26.00.00.20.1-2.2-0.70.70.71.0-1.6-1.0-1.0-2.42.4-2.0-2.2
Delay disc. indifference point, 4s delay0.70.81.3-0.9-0.9-0.9-0.5-1.01.01.01.1-0.5-1.1-1.0-0.40.4-0.9-1.0
Delay disc. indifference point, 8s delay0.40.41.20.30.40.1-1.1-0.4-0.10.00.5-1.0-0.3-0.2-0.90.9-0.7-0.6
Indifference point function ln k0.70.92.60.30.30.41.40.9-0.7-0.7-1.01.60.70.80.9-0.91.21.2
Indifference point function log k0.70.92.60.30.30.41.40.9-0.7-0.7-1.01.60.70.80.9-0.91.21.2
Patch foraging total patch changes 0 sec1.42.38.51.31.30.7-2.9-0.3-0.5-0.20.7-2.30.1-0.2-2.42.3-1.7-1.5
Patch foraging total patch changes 12 sec2.02.610.71.11.10.4-3.3-0.7-0.4-0.01.1-2.8-0.1-0.3-2.32.3-1.9-1.5
Patch foraging total patch changes 18 sec0.70.93.90.40.4-0.1-2.0-0.9-0.20.11.1-1.9-0.3-0.2-1.01.0-1.1-0.9
Patch foraging total patch changes 24 sec1.21.46.00.40.4-0.1-2.5-0.90.10.31.2-2.3-0.4-0.5-1.41.4-1.4-1.2
Patch foraging total patch changes 6 sec1.72.510.51.41.40.8-3.2-0.2-0.6-0.30.7-2.80.2-0.0-2.22.1-1.6-1.2
Patch foraging time to switch 0 sec7.611.729.9-0.6-0.5-0.15.52.1-1.0-1.5-2.74.81.92.35.3-5.34.64.4
Patch foraging water rate 0 sec2.74.310.30.20.2-0.4-3.2-1.60.81.12.0-2.9-1.3-1.5-3.03.0-2.7-2.6
Patch foraging water rate 12 sec0.71.12.51.41.51.6-0.71.2-1.3-1.2-1.00.00.91.0-0.80.70.10.0
Patch foraging water rate 18 sec0.50.72.70.90.80.9-0.70.3-0.2-0.3-0.2-0.30.1-0.1-1.61.6-0.8-0.8
Patch foraging water rate 24 sec0.40.61.80.60.70.4-1.3-0.2-0.3-0.20.5-1.30.00.0-1.31.2-0.8-0.7
Patch foraging water rate 6 sec2.23.29.80.70.70.5-3.1-0.90.10.41.2-2.3-0.7-0.8-3.02.9-2.4-2.3
Seeking ratio, delayed vs. immediate footshock1.41.64.4-1.3-1.4-2.0-0.2-2.11.31.52.0-0.8-1.3-1.30.1-0.0-0.8-0.5
Distance traveled before self-admin0.30.31.0-0.1-0.1-0.6-0.9-1.00.10.31.0-1.0-0.2-0.2-0.10.1-0.5-0.2
Distance traveled after self-admin0.20.21.0-0.4-0.4-0.20.9-0.00.40.2-0.11.0-0.1-0.10.4-0.30.30.3
Extensor digitorum longus weight3.112.321.14.44.34.61.14.4-4.2-4.3-4.32.64.03.9-0.2-0.12.52.3
Bone: elastic displacement1.51.72.60.90.91.00.91.4-1.3-1.4-1.51.21.41.51.3-1.31.61.6
Bone: elastic work2.22.84.81.61.61.30.71.5-2.2-2.0-1.50.92.12.21.3-1.41.92.2
Bone: endosteal estimation2.14.59.0-0.7-0.7-0.7-2.4-1.61.61.71.9-2.3-2.0-2.1-2.92.9-2.9-3.0
Bone: endosteal perimeter2.75.512.2-0.1-0.1-0.4-3.2-1.71.31.52.1-3.0-1.8-2.0-3.53.5-3.3-3.2
Epididymis fat weight0.20.61.60.0-0.1-0.11.30.2-0.3-0.4-0.41.30.40.61.1-1.11.01.0
Delta time in closed arm before/after self-admin0.30.31.50.60.60.3-1.2-0.0-0.3-0.20.2-0.80.30.1-0.80.7-0.5-0.4
Delta time in open arm before/after self-admin0.50.51.50.60.51.10.51.2-0.5-0.7-1.20.70.50.70.2-0.30.60.4
Diff in mean of infusions in LGA sessions0.70.81.4-1.2-1.1-1.10.4-1.11.21.10.9-0.1-1.0-1.1-0.30.4-0.5-0.6
Delay discount exponential model param1.61.73.20.40.20.41.71.1-0.8-0.9-1.31.51.11.11.8-1.81.71.8
Extinction: sum of active levers before priming3.83.87.52.72.72.1-0.11.7-2.7-2.5-1.60.82.62.40.2-0.41.41.6
Active lever presses in extinction session 63.53.47.32.72.72.2-0.81.8-2.5-2.3-1.5-0.32.52.2-0.50.31.01.3
Bone: final force0.00.00.2-0.1-0.1-0.10.4-0.10.00.10.10.1-0.1-0.1-0.10.1-0.0-0.1
Bone: final moment0.00.00.1-0.1-0.1-0.10.3-0.20.20.20.10.0-0.2-0.2-0.30.3-0.2-0.3
Food consumed during 24 hour testing period0.30.41.10.70.70.5-0.9-0.1-0.5-0.30.2-0.50.10.1-1.11.0-0.6-0.6
Glucose1.31.94.02.02.01.9-0.11.5-1.7-1.7-1.40.61.71.6-0.50.30.70.7
Heart weight0.60.82.11.31.31.4-0.90.9-1.0-1.0-0.7-0.50.80.8-0.90.8-0.1-0.1
Delay discount hyperbolic model param1.41.52.80.30.20.41.71.0-0.7-0.8-1.21.41.11.01.7-1.71.61.7
Intermittent access intake day 1-15 change1.51.53.31.41.41.70.21.8-1.2-1.5-1.71.01.21.40.1-0.20.90.8
Intermittent access intake escalation1.81.83.01.71.71.70.01.7-1.5-1.7-1.50.71.61.60.1-0.21.01.1
Intermittent access intake escalation 22.82.84.61.81.91.8-0.11.9-2.0-2.1-1.70.32.02.11.0-1.11.51.8
Intermitt. access day 1 inactive lever presses1.01.13.5-0.0-0.0-0.1-0.7-0.70.70.60.7-0.2-1.0-0.9-1.91.9-1.4-1.6
Intermitt. access day 15 inactive lever presses1.11.24.50.10.10.6-1.00.20.90.5-0.0-0.3-0.8-0.9-2.12.1-1.4-1.7
Intermitt. access escalation Index1.10.91.50.90.90.80.40.9-1.2-1.1-0.90.61.21.20.8-0.91.01.1
Intermittent access day 1 total infusions1.01.14.80.50.6-0.2-2.1-1.0-0.30.21.3-2.2-0.1-0.2-1.11.1-1.1-0.6
Intermittent access day 15 total infusions1.11.23.01.71.71.1-1.60.5-1.4-1.2-0.2-1.21.21.1-0.60.50.10.5
Intermittent access terminal intake (last 3 days)1.01.14.21.41.40.9-2.00.3-1.1-0.90.1-1.80.80.8-0.60.5-0.30.3
Intermittent access total infusions0.70.72.31.21.20.6-1.50.0-1.2-0.80.2-1.30.80.9-0.20.10.00.5
Intermittent access day 1 locomotion1.31.34.50.30.3-0.3-2.1-1.10.10.41.3-2.0-0.6-0.6-1.51.4-1.4-1.1
Intermittent access day 15 total locomotion0.50.61.51.21.20.8-0.30.6-1.2-0.9-0.5-0.10.90.9-0.30.30.30.5
Intermittent access total locomotion0.30.41.41.01.00.6-0.30.3-1.2-0.8-0.20.10.60.8-0.20.10.20.3
Intermittent access standard deviation0.60.61.41.21.21.1-1.10.8-0.7-0.8-0.5-0.40.60.7-0.70.7-0.1-0.0
Left kidney weight1.02.85.11.71.72.10.32.3-1.9-2.1-2.10.71.82.00.7-0.81.61.7
Right kidney weight1.23.55.71.71.72.21.02.4-2.0-2.2-2.31.51.92.21.2-1.31.91.8
Cocaine induced anxiety0.80.92.6-0.5-0.50.0-1.6-0.40.70.60.6-1.5-0.9-0.8-1.11.1-1.2-1.3
Post-drug Anxiety0.50.61.4-0.4-0.50.1-0.9-0.10.80.60.2-0.7-0.9-0.8-1.01.1-1.0-1.2
Baseline Anxiety0.50.62.2-0.4-0.5-0.61.5-0.00.30.2-0.21.10.10.01.2-1.20.80.8
Tail length0.72.25.02.22.21.9-0.81.3-2.2-1.9-1.10.11.71.8-0.50.40.60.6
Length with tail2.17.617.54.24.13.8-1.62.7-3.8-3.5-2.30.13.13.0-1.61.30.80.8
Length without tail1.22.66.42.52.52.1-1.21.3-2.2-2.0-1.1-0.21.81.7-1.21.00.30.5
Times rat made contact with spout0.50.62.5-0.3-0.3-0.21.60.3-0.1-0.2-0.51.40.20.41.1-1.11.00.8
Lifetime Intake0.50.51.41.11.10.5-1.20.1-1.0-0.70.1-1.00.70.7-0.20.10.10.5
Liver weight, left0.20.30.60.80.70.8-0.00.7-0.6-0.7-0.60.40.60.7-0.10.10.30.2
Liver weight, right0.30.40.80.80.80.70.20.6-0.9-0.9-0.60.30.80.90.3-0.40.60.6
Locomotor activity3.45.411.83.43.43.3-2.32.2-2.8-2.5-1.7-1.12.12.0-2.32.1-0.3-0.3
Locomotor testing distance3.66.013.33.63.63.5-1.62.7-3.2-3.0-2.3-0.42.72.5-1.41.20.60.6
Locomotor testing rearing4.87.514.33.83.83.5-0.73.0-3.7-3.5-2.70.03.43.30.1-0.31.71.9
Locomotion in novel chamber0.81.02.5-1.1-1.3-1.50.1-1.20.70.81.1-0.7-0.5-0.41.6-1.50.30.6
Locomotion in novel chamber post-restriction2.12.54.0-1.4-1.5-1.9-0.9-2.01.81.92.0-1.0-1.9-1.8-0.80.9-1.6-1.5
Fecal boli incidents, locomotor time 12.62.84.62.12.11.80.71.8-2.1-2.0-1.81.42.12.00.3-0.41.41.4
Change in fecal boli incidents, locomotor task0.10.10.30.10.10.40.40.5-0.3-0.3-0.50.30.30.30.2-0.30.30.4
Time >=10cm from walls, locomotor time 10.20.20.70.50.40.5-0.70.1-0.3-0.20.0-0.30.10.1-0.80.8-0.4-0.6
Bouts of movement, locomotor time 10.80.83.60.40.30.7-1.00.30.10.2-0.2-0.4-0.4-0.6-1.91.9-1.2-1.1
Total resting periods, locomotor time 10.91.03.90.30.20.7-1.10.30.30.3-0.1-0.5-0.5-0.7-2.01.9-1.3-1.3
Rest time, locomotor task time 11.71.96.1-0.3-0.30.3-1.4-0.30.80.90.5-0.8-1.2-1.4-2.52.5-1.9-2.1
Distance moved, locomotor task time 10.70.82.20.20.30.10.80.5-0.7-0.8-0.60.40.81.01.5-1.51.31.2
Vertical activity count, locomotor time 11.31.42.60.80.70.70.91.1-1.1-1.2-1.10.91.31.41.5-1.51.51.6
Time >=10cm from walls, locomotor time 20.80.92.11.41.41.2-1.50.5-1.2-1.1-0.3-0.70.90.9-0.60.50.00.1
Bouts of movement, locomotor time 20.30.30.6-0.2-0.3-0.5-0.5-0.80.50.60.8-0.3-0.5-0.7-0.70.7-0.7-0.7
Total resting periods, locomotor time 20.30.30.4-0.4-0.5-0.5-0.0-0.70.50.60.60.1-0.6-0.6-0.40.5-0.5-0.6
Rest time, locomotor task time 20.10.21.10.2-0.00.40.70.5-0.0-0.1-0.51.00.10.0-0.10.10.20.0
Distance moved, locomotor task time 20.30.32.20.00.20.0-1.4-0.2-0.1-0.00.4-1.5-0.1-0.1-0.50.5-0.5-0.3
Vertical activity count, locomotor time 20.10.10.7-0.4-0.3-0.4-0.6-0.30.30.40.4-0.8-0.3-0.3-0.00.1-0.3-0.1
Light reinforcement 10.91.62.81.41.51.30.31.2-1.7-1.6-1.20.91.61.70.7-0.81.21.2
Light reinforcement 21.82.45.1-1.3-1.3-1.7-1.1-2.31.41.72.2-1.0-1.7-1.7-1.01.1-1.7-1.6
Bone: marrow area2.14.59.2-0.7-0.7-0.7-2.5-1.61.51.71.9-2.3-2.0-2.1-2.93.0-2.9-3.0
Bone: maximum diameter3.46.315.30.30.3-0.1-3.7-1.71.01.32.2-3.3-1.6-1.8-3.93.9-3.4-3.3
Bone: maximum force0.20.41.1-0.0-0.0-0.1-0.6-0.50.30.40.6-0.8-0.5-0.6-1.11.1-0.9-0.9
Bone: maximum moment0.30.51.4-0.1-0.1-0.2-0.7-0.60.40.50.6-0.8-0.6-0.7-1.21.2-1.0-1.0
Mean time between licks in bursts0.20.31.4-0.0-0.00.80.51.20.1-0.2-1.20.80.10.0-0.20.20.2-0.1
Mean num. licks in bursts0.30.30.70.40.40.50.60.7-0.5-0.6-0.70.80.60.50.3-0.30.60.5
Cd content in liver1.21.32.21.41.41.10.51.1-1.5-1.4-1.10.91.51.40.5-0.51.11.1
Co content in liver0.70.81.31.11.11.1-0.21.1-1.1-1.1-0.90.11.11.20.3-0.40.70.9
Cu content in liver0.20.20.9-0.4-0.4-0.50.4-0.10.10.10.10.10.00.10.9-0.90.50.6
Fe content in liver0.30.30.9-0.3-0.30.01.00.50.1-0.1-0.60.90.20.20.9-0.80.70.6
K content in liver7.27.112.9-3.4-3.4-3.6-0.4-3.43.23.33.2-1.6-3.2-3.00.20.1-1.8-1.7
Mg content in liver4.84.910.2-3.2-3.2-3.20.7-2.62.82.72.3-0.4-2.6-2.41.0-0.8-0.9-0.9
Mn content in liver6.97.911.0-2.6-2.6-2.6-2.1-3.03.13.23.1-2.7-3.3-3.3-1.82.0-3.0-3.0
Na content in liver0.91.02.2-1.4-1.4-1.51.0-1.00.90.90.80.5-0.8-0.61.3-1.20.30.3
Rb content in liver2.32.96.1-2.5-2.5-2.30.5-1.82.32.11.6-0.3-2.0-1.90.6-0.4-0.8-0.9
Se content in liver2.43.07.2-2.5-2.5-2.71.0-2.01.81.81.7-0.0-1.5-1.31.9-1.70.20.3
Sr content in liver0.80.71.00.80.80.80.40.9-1.0-1.0-0.90.71.01.00.5-0.60.90.9
Zn content in liver0.60.72.6-0.4-0.4-1.4-0.7-1.60.40.71.6-1.0-0.4-0.40.2-0.1-0.4-0.1
Bone: minimum diameter0.91.84.90.70.70.3-2.2-0.60.10.30.9-1.9-0.5-0.6-2.22.2-1.7-1.6
Time in familiar zone, hab. session 11.11.01.40.80.80.80.91.0-1.1-1.1-1.01.01.21.20.9-0.91.21.2
Time in novel zone, hab. session 10.40.41.0-0.3-0.30.1-0.6-0.00.60.50.1-0.5-0.7-0.7-1.01.0-0.8-1.0
Total zone transitions, hab. session 12.94.16.0-2.3-2.3-2.4-1.4-2.42.32.42.4-2.0-2.3-2.3-0.30.5-1.7-1.4
Total locomotion distance, hab. session 11.62.35.1-2.3-2.3-2.20.3-1.71.81.81.5-0.4-1.7-1.51.0-0.9-0.4-0.3
Locomotion velocity, hab. session 12.83.97.7-2.6-2.6-2.8-0.6-2.62.32.42.5-1.4-2.2-2.10.4-0.2-1.2-1.0
Time in familiar zone, hab. session 22.12.24.60.50.50.82.11.5-1.0-1.2-1.72.11.21.31.6-1.71.91.7
Time in novel zone, hab. session 21.81.85.00.20.2-0.0-2.2-0.90.50.61.1-2.0-0.7-0.9-2.02.0-1.8-1.6
Total zone transitions, hab. session 25.57.110.2-3.0-3.0-3.1-1.5-3.23.03.13.2-2.4-3.2-3.0-0.70.9-2.4-2.3
Total locomotion distance, hab. session 23.85.07.7-2.6-2.6-2.7-1.0-2.82.52.62.7-1.7-2.7-2.5-0.40.6-1.9-1.9
Locomotion velocity, hab. session 24.86.510.2-2.9-2.9-3.1-1.3-3.22.93.03.1-2.1-3.1-2.9-0.50.7-2.2-2.1
Novel to familiar place preference ratio0.70.71.60.20.2-0.2-1.3-0.70.40.50.8-1.3-0.4-0.6-1.21.2-1.1-0.8
Novelty place preference1.21.23.40.60.60.1-1.9-0.70.30.40.9-1.7-0.3-0.6-1.81.8-1.4-1.1
Time in novel zone, NPP test0.80.92.60.70.70.3-1.5-0.40.10.10.6-1.3-0.1-0.4-1.61.6-1.1-0.9
Total zone transitions, NPP test1.92.74.8-1.7-1.7-2.0-1.2-2.21.71.92.2-1.7-1.8-1.8-0.30.4-1.4-1.2
Total locomotion distance, NPP test2.43.35.2-2.1-2.1-2.3-1.0-2.32.02.12.3-1.6-2.1-2.0-0.20.4-1.5-1.4
Locomotion velocity, NPP test1.92.74.6-1.9-1.9-2.1-0.9-2.11.71.92.1-1.6-1.9-1.7-0.10.2-1.3-1.1
Intraocular pressure1.42.03.71.61.61.90.11.9-1.6-1.7-1.80.81.61.60.3-0.41.11.2
Delta distance traveled before/after self-admin0.30.41.6-0.7-0.7-0.31.20.10.70.4-0.31.2-0.3-0.50.2-0.20.20.1
Delta ambulatory time before/after self-admin0.50.62.6-0.9-0.9-0.41.60.20.80.6-0.41.6-0.5-0.60.4-0.30.3-0.0
Parametrial fat weight2.03.96.02.02.01.71.02.0-2.3-2.3-2.01.52.42.41.4-1.62.12.2
Pavlov. Cond. lever latency1.21.54.10.40.41.11.71.6-0.7-1.0-1.82.00.90.91.0-1.01.41.1
Pavlov. Cond. magazine entry latency1.31.74.4-1.6-1.6-2.10.2-2.01.31.51.9-0.7-1.2-1.10.7-0.6-0.5-0.3
Pavlov. Cond. change in total contacts0.80.91.3-0.7-0.7-0.9-0.9-1.10.91.01.2-1.1-1.0-1.0-0.70.7-1.0-0.9
Pavlov. Cond. index score1.51.94.6-1.3-1.3-2.0-0.8-2.11.31.52.1-1.5-1.3-1.3-0.10.2-1.1-0.8
Pavlov. Cond. latency score1.51.94.5-1.3-1.3-1.9-0.9-2.11.31.52.1-1.6-1.3-1.3-0.20.3-1.1-0.9
Pavlov. Cond. lever contacts0.30.41.5-0.0-0.0-0.7-0.9-1.00.10.31.1-1.2-0.2-0.2-0.30.3-0.5-0.3
Pavlov. Cond. magazine entry number1.92.45.31.91.92.30.22.3-1.7-1.8-2.21.11.61.5-0.30.20.90.7
Pavlov. Cond. intertrial magazine entries1.82.13.81.51.51.80.92.0-1.6-1.7-2.01.21.61.60.5-0.61.41.2
Pavlov. Cond. lever-magazine prob. diff.1.31.74.0-1.3-1.3-1.9-0.6-2.01.21.42.0-1.3-1.3-1.20.00.0-0.9-0.7
Pavlov. Cond. response bias1.31.63.5-1.3-1.3-1.8-0.6-1.91.21.41.9-1.3-1.3-1.20.00.0-0.9-0.7
Pavlov. Cond. lever latency0.91.23.0-1.0-1.0-1.51.7-1.00.60.60.61.1-0.2-0.11.7-1.70.90.9
Pavlov. Cond. magazine entry latency0.00.00.1-0.2-0.2-0.20.0-0.20.20.20.2-0.0-0.1-0.10.1-0.1-0.0-0.0
Pavlov. Cond. change in total contacts1.21.73.61.61.61.8-1.91.2-1.2-1.0-0.9-1.20.70.6-1.71.6-0.6-0.6
Pavlov. Cond. index score0.70.82.11.11.11.2-1.50.8-0.7-0.7-0.5-0.90.40.4-1.31.2-0.5-0.5
Pavlov. Cond. latency score0.60.82.50.90.91.0-1.60.5-0.6-0.4-0.2-1.10.30.2-1.31.3-0.7-0.6
Pavlov. Cond. lever contacts0.60.81.91.01.01.4-1.11.0-0.7-0.7-0.8-0.60.40.4-1.21.2-0.4-0.5
Pavlov. Cond. magazine entry number0.30.41.2-0.4-0.4-0.51.1-0.10.0-0.0-0.10.70.10.21.1-1.10.80.8
Pavlov. Cond. intertrial magazine entries0.20.20.7-0.8-0.8-0.40.1-0.10.70.60.1-0.0-0.8-0.60.2-0.1-0.2-0.4
Pavlov. Cond. lever-magazine prob. diff.0.70.81.71.11.11.3-1.30.9-0.8-0.7-0.6-0.70.50.4-1.31.2-0.5-0.5
Pavlov. Cond. response bias0.40.61.50.90.91.2-1.01.0-0.6-0.6-0.7-0.60.40.3-1.01.0-0.3-0.4
Time in closed arm before self-admin1.21.33.7-1.5-1.5-1.90.9-1.70.91.11.4-0.3-0.9-0.71.1-1.00.20.4
Time in closed arm after self-admin1.11.23.0-1.2-1.2-1.7-0.3-1.71.11.21.6-0.8-0.9-1.00.2-0.1-0.6-0.2
Time in open arm before self-admin0.80.92.6-0.2-0.2-0.5-1.6-0.90.60.71.1-1.6-0.6-0.8-1.01.0-1.2-1.0
Time in open arm after self-admin0.70.82.1-0.7-0.7-0.5-1.2-0.61.00.90.7-1.5-1.1-0.9-0.40.5-0.9-1.0
Bone: periosteal estimation2.45.012.1-0.1-0.1-0.3-2.9-1.61.11.41.9-2.7-1.7-1.8-3.53.5-3.1-3.1
Bone: periosteal perimeter1.83.17.70.40.4-0.0-2.6-1.20.60.81.5-2.3-1.0-1.2-2.82.8-2.4-2.3
Bone: post-yield work0.81.12.5-0.3-0.3-0.0-1.1-0.50.80.80.6-1.0-1.1-1.0-1.51.6-1.4-1.6
Progressive ratio test 1 active lever presses0.50.52.10.60.70.5-1.4-0.1-0.4-0.20.3-1.20.10.0-1.00.9-0.7-0.5
Progressive ratio test 1 breakpoint0.70.72.80.30.30.1-1.7-0.50.00.20.7-1.5-0.3-0.4-1.21.2-1.1-0.9
Progressive ratio test 1 inactive lever presses1.01.13.70.60.60.5-1.9-0.3-0.20.00.6-1.5-0.3-0.3-1.71.7-1.3-1.1
Progressive ratio test 2 active lever presses0.50.52.0-0.4-0.3-0.9-0.9-1.20.30.51.2-1.4-0.4-0.40.2-0.1-0.4-0.0
Progressive ratio test 2 breakpoint0.50.62.2-0.5-0.4-1.0-1.1-1.20.30.61.3-1.5-0.5-0.40.3-0.3-0.4-0.0
Progressive ratio test 2 inactive lever presses0.70.83.80.50.50.4-1.9-0.2-0.1-0.00.5-1.7-0.2-0.1-1.21.1-1.0-0.7
Incentive Sensitization - Responses1.51.54.0-1.5-1.3-2.00.5-1.70.70.91.5-0.5-0.7-0.41.9-1.80.50.9
Incentive Sensitization - Breakpoint1.31.43.4-1.3-1.2-1.90.4-1.60.60.81.4-0.6-0.6-0.31.8-1.70.50.9
Sum of active levers in priming session hrs 5-61.11.12.11.41.41.3-0.71.2-1.3-1.2-1.0-0.31.31.2-0.40.30.40.7
Progressive ratio1.21.33.4-1.7-1.8-0.90.6-0.41.81.50.20.3-1.5-1.6-0.30.4-0.8-1.1
Food seeking constrained by brief footshock0.40.50.8-0.8-0.8-0.3-0.2-0.40.90.80.4-0.5-0.9-0.9-0.60.6-0.8-0.9
Seeking ratio, punishment vs. effort0.40.41.11.01.00.7-0.70.3-1.0-0.9-0.2-0.40.80.9-0.0-0.10.30.4
Retroperitoneal fat weight2.16.911.51.71.71.33.12.0-2.3-2.5-2.43.32.72.92.8-2.93.43.4
Reaction time number correct0.50.71.20.70.70.60.40.7-0.9-0.9-0.70.30.91.00.8-0.91.01.1
Reaction time mean minus median5.67.414.4-3.7-3.8-3.8-0.1-3.43.33.33.1-1.5-3.0-2.90.9-0.6-1.4-1.3
Reaction time mean minus median AUC3.95.110.6-3.2-3.3-3.0-0.3-2.62.72.72.5-1.4-2.6-2.40.7-0.5-1.2-1.2
Reaction time num false alarms0.20.20.7-0.0-0.10.3-0.40.10.40.3-0.0-0.3-0.4-0.5-0.80.8-0.7-0.8
Reaction time num false alarms AUC0.20.30.9-0.2-0.20.1-0.3-0.00.50.40.1-0.2-0.5-0.6-0.80.8-0.7-0.9
Reaction time trials correct on left0.50.71.20.70.70.60.40.7-0.9-0.9-0.70.30.91.00.8-0.91.01.1
Reaction time trials on left0.30.50.90.60.60.50.30.6-0.7-0.8-0.60.20.80.90.8-0.80.91.0
Reaction time mean0.60.81.8-1.3-1.4-1.10.7-0.61.10.90.5-0.2-0.5-0.61.2-1.10.30.4
Reaction time mean AUC0.60.82.2-1.3-1.3-1.10.8-0.50.90.70.4-0.1-0.4-0.51.5-1.40.50.6
Median of all reaction times0.40.51.7-0.2-0.30.01.00.50.0-0.2-0.60.50.50.41.3-1.31.01.0
Reaction time omissions3.85.29.4-3.0-3.0-2.7-0.7-2.53.12.92.4-1.5-2.7-2.8-0.10.3-1.7-1.8
Reaction time false alarm rate0.40.51.7-0.2-0.30.1-0.5-0.10.60.60.1-0.3-0.7-0.8-1.21.2-1.0-1.3
Reaction time premature initiation rate0.60.73.30.50.40.4-1.8-0.1-0.3-0.10.4-1.6-0.1-0.1-1.21.2-0.9-0.8
Reaction time premature initiations0.40.62.70.70.70.6-1.60.2-0.7-0.50.1-1.50.30.3-0.70.6-0.5-0.3
Std. dev. reaction times3.24.59.5-3.0-3.1-2.90.2-2.42.82.72.2-1.0-2.4-2.40.8-0.6-1.0-1.0
Reaction time trials completed0.30.50.90.60.60.50.30.6-0.7-0.8-0.60.20.80.90.8-0.80.91.0
Reaction time trials AUC0.50.81.30.80.90.70.40.9-1.0-1.0-0.80.41.01.10.8-0.81.01.1
Run reversals in cocaine runway, females1.71.73.1-1.6-1.6-1.20.8-1.21.71.60.90.7-1.7-1.8-0.60.8-1.0-1.5
Run reversals in cocaine runway, males0.30.31.70.10.1-0.4-1.0-0.6-0.20.00.7-1.30.20.20.3-0.3-0.10.3
Latency to leave start box in cocaine runway0.20.20.8-0.4-0.5-0.20.90.10.30.1-0.30.9-0.1-0.10.4-0.40.30.2
Latency to leave start box in cocaine runway, F0.40.41.7-0.8-0.8-0.31.30.10.50.3-0.31.3-0.4-0.30.4-0.40.3-0.1
Latency to leave start box in cocaine runway, M0.00.00.10.20.1-0.0-0.3-0.00.00.00.1-0.3-0.1-0.0-0.10.1-0.1-0.0
Std. dev. time between licks in bursts0.10.10.5-0.4-0.4-0.40.1-0.20.20.10.1-0.10.00.00.7-0.70.30.5
Total sessions with >9 infusions0.70.71.81.31.31.3-0.50.9-0.9-0.9-0.80.20.60.6-1.00.9-0.1-0.1
Short access day 1 total inactive lever presses3.33.77.92.82.82.7-1.32.2-2.6-2.4-1.8-0.22.12.1-0.80.60.70.8
Short access day 10 total inactive lever presses1.41.53.1-0.3-0.4-0.4-1.6-0.90.90.91.1-1.7-1.0-1.1-1.71.8-1.6-1.5
Short access day 1 total infusions1.51.63.41.81.81.7-1.31.3-1.7-1.5-0.9-0.61.41.3-0.50.40.30.6
Short access day 10 total infusions0.30.31.30.50.50.0-1.1-0.6-0.20.00.7-0.8-0.1-0.1-0.80.8-0.7-0.4
Short access total infusions0.30.41.20.80.80.4-1.1-0.0-0.9-0.60.2-1.00.60.60.1-0.10.10.5
Short access day 1 locomotion0.60.71.81.41.21.1-1.00.7-1.1-0.9-0.5-0.40.80.8-0.20.10.10.3
Short access day 10 total locomotion0.20.20.50.60.70.5-0.30.2-0.5-0.5-0.10.20.40.4-0.50.5-0.1-0.0
Short access total locomotion0.40.51.31.11.10.8-0.90.3-0.8-0.7-0.1-0.20.60.5-0.70.6-0.3-0.1
One hour access (0.3 mA shock)1.41.63.91.92.01.6-1.60.8-1.5-1.4-0.5-1.01.21.2-1.00.8-0.10.3
Compulsive drug intake0.40.40.9-0.9-0.8-0.30.1-0.30.80.80.2-0.1-0.7-0.9-0.60.7-0.7-1.0
One hour access (shock baseline)1.21.33.31.81.81.2-1.20.6-1.5-1.4-0.4-0.81.41.50.0-0.20.51.1
Social response proportion0.10.20.50.30.30.5-0.50.4-0.1-0.1-0.3-0.10.1-0.1-0.70.7-0.4-0.5
Social responses0.30.41.00.70.70.7-0.90.2-0.2-0.2-0.1-0.50.30.0-1.01.0-0.6-0.6
Social time1.72.35.82.12.12.4-0.82.1-1.6-1.7-1.8-0.01.61.4-0.60.50.40.4
Soleus weight0.51.34.81.11.11.1-1.70.2-0.4-0.30.0-0.9-0.0-0.1-2.22.1-1.3-1.3
Bone: stiffness1.32.02.9-1.2-1.2-1.3-0.8-1.71.51.61.7-1.3-1.6-1.6-1.11.2-1.6-1.6
Tibialis anterior weight3.210.819.84.34.34.40.44.1-4.0-4.1-3.92.03.83.7-0.50.22.12.0
Time to tail flick, vehicle, before self-admin0.30.30.5-0.6-0.6-0.5-0.5-0.50.70.60.5-0.7-0.7-0.7-0.40.4-0.6-0.6
Time to tail flick, vehicle, after self-admin0.80.91.7-0.5-0.5-0.7-0.6-1.10.80.91.1-0.7-1.0-1.0-1.01.0-1.2-1.3
Time to tail flick, test, before self-admin0.20.20.50.40.50.2-0.30.2-0.7-0.5-0.1-0.60.60.50.4-0.40.40.5
Time to tail flick, test, after self-admin1.61.64.91.31.32.00.32.2-1.2-1.3-2.11.21.21.0-0.40.40.50.3
Delta time to tail flick, vehicle, before/after SA0.30.30.7-0.2-0.2-0.2-0.3-0.40.50.50.4-0.3-0.6-0.6-0.70.7-0.7-0.9
Delta time to tail flick, test, before/after SA0.60.53.2-0.1-0.10.61.11.00.3-0.1-1.11.8-0.1-0.1-0.10.20.2-0.2
Tibia length0.41.14.71.31.30.8-0.9-0.2-0.5-0.30.3-0.10.1-0.0-2.22.1-1.1-1.2
Ambulatory time before self-admin0.20.20.90.00.0-0.5-0.8-0.8-0.00.20.9-1.0-0.0-0.0-0.00.0-0.3-0.1
Ambulatory time after self-admin0.30.41.3-0.3-0.3-0.11.20.30.0-0.1-0.51.10.30.20.8-0.80.70.7
Bone: tissue strength0.20.20.7-0.3-0.3-0.10.70.30.1-0.1-0.40.50.10.20.8-0.80.60.6
Total heroin consumption1.01.12.51.51.51.6-0.31.2-1.3-1.2-1.10.31.20.9-0.90.80.20.1
Bone: trabecular number2.74.26.82.52.52.50.62.5-2.6-2.6-2.41.42.42.40.3-0.41.71.6
Bone: trabecular spacing2.02.55.8-2.2-2.2-2.41.9-1.61.61.61.20.9-1.2-1.11.8-1.60.50.4
Bone: trabecular thickness1.21.43.31.51.51.8-0.31.7-1.4-1.4-1.50.31.21.2-0.50.40.40.4
Bone: trabecular tissue density2.23.04.8-2.0-2.0-2.0-0.8-2.02.22.12.0-1.4-2.1-2.0-0.40.5-1.6-1.5
Water consumed over 24 hours0.91.01.81.21.21.10.61.0-1.3-1.3-1.11.01.11.20.3-0.30.90.8
Number of responses in last shaping day0.20.21.00.10.1-0.0-1.0-0.40.40.20.6-0.6-0.3-0.2-0.70.7-0.6-0.5