Cobll1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Cobll1 0.05 0.03 9.3e-05 0.05 0.05 0.03 0.05 2.5e-05 1.6e-05 3.4e-04 2.5e-05
2 NAcc isoform ratio XM_039106332.2 0.02 0.01 5.6e-03 0.02 0.01 0.01 0.01 1.3e-03 2.6e-03 7.2e-03 3.4e-03
3 pVTA gene expression Cobll1 0.08 0.04 4.2e-07 0.07 0.07 0.06 0.06 1.2e-06 3.7e-06 6.7e-06 7.3e-06
4 BLA gene expression Cobll1 0.08 0.04 4.6e-04 0.05 0.04 0.04 0.05 1.9e-03 2.0e-03 5.9e-03 1.3e-03
5 Liver mRNA stability Cobll1 0.08 0.04 1.1e-09 0.04 0.07 0.06 0.07 4.8e-05 3.8e-08 1.6e-07 7.0e-08
6 LHb mRNA stability Cobll1 0.22 0.11 6.4e-03 0.04 0.01 -0 0.02 3.2e-02 1.7e-01 4.5e-01 1.3e-01
7 NAcc gene expression Cobll1 0.04 0.02 1.9e-06 0.05 0.04 0.05 0.05 2.8e-08 1.2e-06 1.4e-07 2.4e-08
8 IC gene expression Cobll1 0.09 0.05 9.1e-03 0 0.01 -0 -0 2.5e-01 8.1e-02 5.6e-01 4.8e-01
9 BLA mRNA stability Cobll1 0.23 0.08 8.1e-10 0.11 0.17 0.16 0.15 3.0e-06 3.7e-09 1.3e-08 1.9e-08
10 PL gene expression Cobll1 0.11 0.05 4.9e-08 0.07 0.07 0.05 0.07 2.5e-08 2.2e-08 2.0e-06 8.3e-08
11 pVTA isoform ratio XM_039106332.2 0.05 0.03 1.3e-03 0.02 0.04 0.03 0.03 1.2e-02 4.3e-04 1.2e-03 1.8e-03
12 Adipose gene expression Cobll1 0.41 0.1 0.0e+00 0.13 0.15 0.13 0.13 2.7e-14 1.6e-16 2.3e-14 3.8e-14
13 Brain mRNA stability Cobll1 0.53 0.1 0.0e+00 0.32 0.42 0.43 0.44 1.7e-30 2.0e-42 9.2e-44 2.5e-44
14 OFC mRNA stability Cobll1 0.51 0.13 1.6e-06 0.16 0.25 0.24 0.24 1.1e-04 1.2e-06 2.5e-06 1.9e-06
15 NAcc mRNA stability Cobll1 0.09 0.03 3.8e-14 0.1 0.1 0.09 0.1 2.3e-15 1.6e-15 4.1e-14 3.2e-14
16 IC mRNA stability Cobll1 0.3 0.09 6.6e-12 0.23 0.25 0.23 0.24 7.2e-10 8.6e-11 3.2e-10 2.4e-10
17 IL mRNA stability Cobll1 0.5 0.12 3.7e-08 0.23 0.34 0.36 0.36 2.3e-06 4.4e-09 1.2e-09 1.8e-09
18 pVTA mRNA stability Cobll1 0.14 0.06 5.0e-09 0.12 0.13 0.11 0.11 1.2e-09 2.1e-10 2.4e-09 3.7e-09
19 PL mRNA stability Cobll1 0.35 0.09 0.0e+00 0.19 0.28 0.27 0.28 8.8e-21 3.9e-31 1.9e-29 2.5e-30
20 Adipose intron excision ratio chr3_70219138_70220179 0.05 0.04 3.1e-03 0.01 0 0 0 2.8e-02 2.4e-01 2.6e-01 1.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density0.50.81.81.0-1.01.21.2-0.4-1.31.20.3-1.00.4-1.10.9-0.5-0.5-1.1-1.40.4-0.9-0.60.8
Area under the delay curve0.30.31.10.4-0.50.70.7-0.9-0.70.60.9-0.20.9-0.30.3-0.6-0.40.00.2-1.00.10.1-0.6
BMI with tail0.30.92.90.5-0.20.40.40.4-0.50.30.2-0.90.6-1.30.7-1.5-1.0-1.3-1.6-1.0-1.7-1.6-0.5
BMI without tail0.00.10.2-0.30.1-0.4-0.40.10.2-0.10.00.3-0.20.3-0.0-0.00.10.40.4-0.20.30.20.1
Body weight0.20.73.4-0.71.0-0.1-0.21.90.0-0.7-1.30.5-0.9-0.0-1.20.20.9-0.7-1.00.5-0.9-0.20.8
Weight adjusted by age0.60.91.81.1-1.00.91.0-0.8-0.91.00.8-1.30.9-1.11.4-0.8-1.0-1.1-1.0-0.2-0.8-0.80.1
Bone surface0.10.10.6-0.10.20.30.30.4-0.5-0.1-0.8-0.0-0.4-0.2-0.20.20.4-0.3-0.60.6-0.10.00.3
Bone volume0.10.20.80.2-0.20.50.50.4-0.50.4-0.3-0.3-0.3-0.40.10.10.1-0.6-0.80.5-0.4-0.20.9
Breakpoint value in progressive ratio session2.73.26.02.2-2.02.42.4-2.3-2.42.22.1-1.62.2-1.71.1-1.7-1.4-1.4-1.1-0.9-1.1-0.9-0.6
Number of licking bursts0.20.31.90.1-0.20.10.00.10.10.1-0.50.1-0.80.3-0.20.90.70.1-0.11.40.20.51.4
Context. condit. distance diff. score0.30.32.30.5-0.10.80.8-0.2-0.90.20.6-0.10.10.1-0.50.60.7-0.40.10.2-0.10.71.5
Locomotion velocity, session 10.50.51.60.40.10.50.5-0.2-0.40.30.4-0.61.2-0.80.2-1.3-1.0-0.7-0.6-0.5-0.8-1.0-1.2
Locomotion distance, session 10.10.21.30.20.10.50.5-0.1-0.50.70.2-0.20.3-0.30.2-0.0-0.1-0.3-0.31.2-0.1-0.10.2
Locomotion velocity, session 20.40.51.60.6-0.90.20.2-1.0-0.20.61.0-0.60.9-0.51.3-0.9-1.20.1-0.1-0.6-0.2-0.7-0.8
Locomotion distance, session 20.81.04.6-1.31.0-1.0-1.01.31.0-0.7-1.41.1-1.20.7-0.60.90.70.90.32.10.60.5-0.1
Locomotion velocity, session 30.60.61.40.9-0.80.91.0-0.6-1.01.20.6-1.00.7-1.00.9-0.7-0.7-0.9-0.90.3-0.7-0.70.1
Locomotion distance, session 30.10.10.6-0.00.30.50.5-0.3-0.60.2-0.30.2-0.00.1-0.40.30.40.30.20.80.50.5-0.1
Stereotopy head waving bouts, day 31.92.36.7-1.31.0-1.1-1.31.91.1-1.5-2.01.3-2.41.2-1.11.81.80.80.22.60.51.01.8
Stereotopy head waving duration, day 31.01.23.5-0.90.7-0.9-1.01.51.0-1.1-1.30.8-1.70.8-0.71.31.20.40.01.90.20.61.7
Locomotion velocity, session 70.50.51.2-0.80.6-1.0-0.90.20.8-0.5-0.60.8-0.50.8-0.30.50.41.11.00.51.10.7-0.6
Locomotion distance, session 70.50.71.3-0.90.9-0.8-0.80.70.8-0.5-1.00.9-0.90.8-0.90.80.70.80.71.10.80.6-0.1
Stereotopy head waving bouts, day 70.60.73.10.1-0.40.60.50.1-0.70.4-0.60.4-1.00.3-0.41.21.20.3-0.01.80.61.01.7
Stereotopy head waving duration, day 70.60.72.9-0.2-0.10.30.30.1-0.50.1-0.70.6-1.00.6-0.81.31.40.50.31.70.81.21.5
Locomotion velocity, session 80.10.20.7-0.20.4-0.1-0.1-0.20.1-0.20.20.4-0.00.5-0.40.40.30.50.8-0.20.60.60.3
Locomotion distance, session 80.30.43.10.10.30.60.60.4-0.70.2-0.10.1-0.40.1-0.60.80.9-0.3-0.21.3-0.00.71.7
Degree of sensitization distance0.30.32.1-0.1-0.2-0.4-0.40.50.40.1-0.10.3-0.80.4-0.30.80.60.00.10.90.00.41.4
Degree of sensitization stereotypy0.91.02.71.2-1.41.61.6-0.9-1.71.60.6-0.80.4-0.90.6-0.2-0.0-0.7-0.90.5-0.40.01.1
Conditioned locomotion0.40.53.0-0.1-0.10.20.20.0-0.10.2-0.40.3-0.90.40.10.90.90.40.21.60.70.91.7
Cocaine response after cond. corrected1.41.72.61.6-1.51.61.5-1.0-1.41.61.4-1.51.1-1.41.1-0.9-1.0-1.6-1.3-0.5-1.3-1.00.9
Cocaine response after cond. not corrected0.10.21.60.1-0.20.20.20.2-0.20.20.10.0-0.40.1-0.10.70.5-0.3-0.10.6-0.00.41.2
Cocaine response before conditioning5.06.08.8-2.62.5-2.4-2.42.22.0-2.6-2.52.8-2.82.7-2.53.02.92.32.21.92.42.60.8
Saline control response1.01.33.80.9-0.70.60.80.2-0.90.90.6-1.30.8-1.50.9-1.3-1.1-1.8-1.8-0.8-2.0-1.60.4
Bone: connectivity density0.71.12.91.2-1.01.51.5-0.4-1.71.10.1-1.10.6-1.30.7-0.7-0.4-1.4-1.60.2-1.0-0.70.6
Bone: cortical apparent density0.50.72.80.6-0.50.50.60.2-0.80.6-0.3-1.00.3-1.20.5-0.8-0.8-1.3-1.70.2-1.3-1.3-0.1
Bone: cortical area2.33.57.3-2.32.4-2.1-2.22.72.2-2.3-2.12.0-2.11.8-2.11.71.61.21.01.30.70.90.2
Bone: cortical porosity1.21.33.3-0.90.9-0.2-0.30.40.2-0.7-0.71.4-1.01.3-1.61.41.81.21.31.41.41.70.6
Bone: cortical porosity1.21.32.8-1.21.5-0.6-0.70.90.7-1.3-1.01.4-0.91.3-1.71.21.51.01.10.91.11.3-0.0
Bone: cortical thickness0.50.93.7-1.11.0-1.2-1.21.91.2-1.0-1.20.7-1.20.4-0.80.40.4-0.0-0.40.9-0.7-0.40.5
Bone: cortical thickness1.51.83.4-1.51.4-1.3-1.41.81.4-1.2-1.41.4-1.91.3-1.51.61.50.70.71.40.50.91.3
Bone: cortical tissue density0.60.83.00.8-0.60.60.70.1-0.90.8-0.3-1.10.4-1.30.7-0.9-0.9-1.3-1.70.1-1.3-1.4-0.1
Condit. Reinf. active minus inactive responses1.92.16.5-1.51.5-1.1-1.11.61.1-1.2-2.21.5-2.01.3-1.51.41.71.00.62.51.11.10.8
Condit. Reinf. active-inactive response ratio0.70.72.1-0.90.9-0.7-0.71.00.6-0.6-1.20.9-1.10.8-0.90.81.00.60.41.40.60.70.6
Condit. Reinf. active responses2.93.66.5-2.12.3-1.7-1.71.91.7-2.1-2.61.9-2.21.9-1.91.82.01.71.32.51.71.50.3
Condit. Reinf. inactive responses2.02.44.6-1.82.1-1.6-1.61.31.6-2.1-1.91.5-1.61.6-1.41.41.41.61.41.41.51.1-0.4
Incentive salience index mean1.82.35.8-1.61.6-1.2-1.21.71.1-1.3-2.41.6-2.01.3-1.71.41.71.10.52.41.11.10.5
Condit. Reinf. lever presses0.20.31.2-0.60.7-0.5-0.51.00.4-0.6-1.10.5-0.80.3-0.70.20.50.1-0.20.7-0.00.10.2
Condit. Reinf. active minus inactive responses2.02.56.8-2.12.4-2.0-2.02.61.8-2.2-2.01.4-1.81.2-1.31.21.30.70.51.00.40.60.3
Condit. Reinf. active-inactive response ratio0.91.12.6-1.41.5-1.5-1.41.61.4-1.3-1.30.9-1.20.8-0.60.80.60.60.40.80.40.3-0.0
Condit. Reinf. active responses2.33.28.7-2.32.6-2.1-2.12.92.0-2.6-2.41.6-2.11.4-1.81.31.60.80.41.00.30.70.5
Condit. Reinf. inactive responses0.50.61.8-0.81.0-0.7-0.81.40.7-1.2-0.90.6-1.00.6-0.90.50.90.10.00.3-0.10.41.0
Condit. Reinf. lever presses3.65.010.3-2.72.7-2.6-2.63.22.6-2.7-2.82.0-3.02.0-1.82.12.11.30.92.00.91.31.5
Condit. Reinf. lever reinforcers received1.72.37.2-2.02.3-2.0-2.02.71.9-2.2-2.11.2-1.81.0-1.30.91.00.50.20.80.00.20.4
Conditioned reinforcement - actives1.01.83.7-1.51.6-1.6-1.41.31.0-1.2-1.31.7-1.31.5-1.91.21.41.31.20.81.11.20.2
Conditioned reinforcement - inactives0.50.81.6-0.91.0-0.7-0.60.30.4-0.8-0.71.1-0.61.0-1.30.81.01.21.10.21.11.0-0.6
Conditioned locomotion0.30.42.0-0.70.7-0.7-0.60.80.4-0.4-0.20.9-0.30.7-1.40.20.50.50.7-0.70.10.40.0
Patch foraging indifference point 0 sec0.61.25.41.0-1.11.01.10.1-0.91.2-0.3-1.0-0.6-1.00.40.1-0.2-1.3-1.81.3-1.2-0.72.3
Patch foraging indifference point AUC1.31.95.6-1.51.2-1.3-1.2-0.11.3-1.5-0.61.4-0.51.6-0.51.10.82.12.3-0.02.41.6-1.2
Delay disc. indifference point, 0s delay0.30.31.3-0.40.8-0.3-0.20.70.2-0.6-0.70.00.2-0.3-0.6-0.7-0.2-0.4-0.5-0.3-0.6-0.7-1.1
Delay disc. indifference point, 16s delay0.30.31.00.0-0.50.30.3-0.7-0.40.40.20.5-0.10.5-0.40.50.50.90.80.21.01.00.2
Delay disc. indifference point, 2s delay0.60.75.4-0.20.3-0.4-0.3-0.00.3-0.3-0.3-0.20.8-0.60.5-1.5-1.2-0.0-0.4-0.8-0.4-1.1-2.3
Delay disc. indifference point, 24s delay0.50.61.70.3-0.40.90.9-1.2-1.00.50.70.40.30.5-0.60.70.70.81.00.11.11.30.2
Delay disc. indifference point, 4s delay1.81.94.70.9-0.51.21.2-0.9-1.30.71.3-1.12.0-1.51.1-2.2-1.6-1.2-1.0-2.0-1.1-1.3-1.9
Delay disc. indifference point, 8s delay0.30.31.10.4-0.80.60.5-0.9-0.60.81.1-0.10.5-0.20.5-0.3-0.30.20.3-0.80.20.3-0.1
Indifference point function ln k0.10.20.60.00.3-0.0-0.00.7-0.10.1-0.7-0.1-0.4-0.3-0.3-0.10.2-0.6-0.80.6-0.6-0.40.5
Indifference point function log k0.10.20.60.00.3-0.0-0.00.7-0.10.1-0.7-0.1-0.4-0.3-0.3-0.10.2-0.6-0.80.6-0.6-0.40.5
Patch foraging total patch changes 0 sec0.91.85.21.4-1.61.41.5-0.2-1.41.70.1-1.4-0.1-1.40.8-0.2-0.5-1.6-2.11.1-1.5-1.02.3
Patch foraging total patch changes 12 sec0.70.91.6-1.10.7-0.9-0.80.71.0-0.8-1.11.1-1.11.0-1.11.30.91.10.90.71.00.90.0
Patch foraging total patch changes 18 sec1.21.93.7-1.20.7-1.2-1.10.41.3-0.9-1.21.4-1.71.6-0.71.91.41.91.51.81.91.60.9
Patch foraging total patch changes 24 sec0.61.02.9-0.90.4-1.2-1.21.31.3-0.7-1.10.6-1.70.7-0.31.10.60.50.11.40.10.21.6
Patch foraging total patch changes 6 sec0.20.31.60.5-0.80.50.6-0.5-0.40.8-0.1-0.3-0.5-0.10.20.60.10.1-0.21.10.20.21.3
Patch foraging time to switch 0 sec0.40.81.61.2-1.11.01.0-0.6-0.91.01.0-0.80.8-0.90.3-0.6-0.5-1.2-1.0-0.6-1.3-0.80.5
Patch foraging water rate 0 sec1.32.74.7-1.91.7-1.3-1.31.81.3-1.5-2.21.8-2.01.6-2.01.71.81.51.12.11.41.50.4
Patch foraging water rate 12 sec0.81.83.4-1.81.8-1.8-1.81.81.8-1.5-1.81.3-1.41.0-1.10.50.61.10.61.20.60.3-0.6
Patch foraging water rate 18 sec0.40.62.2-1.11.3-0.9-0.81.50.9-0.8-0.70.4-0.1-0.0-0.8-0.6-0.4-0.1-0.2-0.4-0.6-0.7-1.1
Patch foraging water rate 24 sec0.10.10.6-0.30.1-0.4-0.30.40.40.1-0.20.0-0.40.00.10.1-0.10.1-0.00.8-0.0-0.10.5
Patch foraging water rate 6 sec1.21.73.1-1.71.7-1.5-1.51.81.5-1.7-1.71.4-1.31.2-1.60.81.01.00.71.10.60.6-0.2
Seeking ratio, delayed vs. immediate footshock0.40.50.9-0.80.5-0.9-1.00.70.8-0.5-0.80.8-0.90.7-0.50.50.80.60.40.70.60.60.3
Distance traveled before self-admin0.70.92.6-1.01.2-0.8-1.01.60.8-1.0-1.20.9-1.00.7-1.60.71.00.10.11.1-0.20.20.3
Distance traveled after self-admin2.12.64.6-2.02.1-1.9-2.11.92.0-1.9-1.91.8-1.41.6-1.91.01.21.31.21.31.00.8-0.6
Extensor digitorum longus weight0.31.24.8-1.30.8-2.2-2.01.71.9-1.1-1.40.5-1.20.40.2-0.0-0.40.4-0.20.4-0.2-0.8-0.6
Bone: elastic displacement0.70.92.00.7-0.80.30.2-0.1-0.20.60.7-1.10.7-1.11.2-1.2-1.3-1.1-1.2-0.8-1.4-1.4-0.2
Bone: elastic work1.82.47.50.8-0.6-0.1-0.00.70.20.40.5-1.80.7-1.92.3-1.9-2.3-2.0-2.4-0.8-2.6-2.70.1
Bone: endosteal estimation1.32.96.4-1.91.9-1.5-1.70.81.7-1.8-0.72.0-1.12.2-1.51.81.62.12.50.12.22.0-0.5
Bone: endosteal perimeter2.24.78.4-2.72.9-2.3-2.41.92.5-2.9-1.92.4-1.72.4-1.91.91.82.22.40.42.21.8-1.2
Epididymis fat weight6.522.237.15.7-5.95.65.6-5.0-5.56.15.2-5.24.6-4.94.9-4.0-4.2-4.3-3.9-2.9-3.5-3.20.8
Delta time in closed arm before/after self-admin0.30.30.50.5-0.70.40.4-0.2-0.50.70.4-0.60.4-0.70.7-0.5-0.6-0.6-0.70.2-0.6-0.60.3
Delta time in open arm before/after self-admin0.20.20.7-0.30.7-0.5-0.50.80.6-0.5-0.5-0.0-0.40.1-0.40.0-0.0-0.4-0.3-0.4-0.5-0.40.3
Diff in mean of infusions in LGA sessions8.210.017.64.0-3.74.24.2-3.5-4.23.83.4-3.33.5-3.32.6-2.7-2.4-2.9-2.7-1.3-2.4-2.00.2
Delay discount exponential model param0.40.51.5-0.50.7-0.8-0.71.10.8-0.7-1.10.3-1.00.4-0.50.70.5-0.1-0.31.2-0.2-0.10.7
Extinction: sum of active levers before priming0.20.20.60.10.10.40.20.3-0.30.0-0.2-0.30.5-0.5-0.6-0.7-0.2-0.8-0.7-0.6-0.8-0.7-0.2
Active lever presses in extinction session 60.60.61.8-0.20.30.50.51.0-0.40.0-1.30.1-0.2-0.6-1.0-0.60.1-0.7-1.31.3-1.0-0.8-0.3
Bone: final force3.04.88.0-2.82.7-2.8-2.81.82.8-2.7-1.52.5-1.62.5-1.71.71.42.42.60.52.01.6-1.4
Bone: final moment2.94.79.0-2.82.7-3.0-3.01.93.0-2.7-1.52.4-1.62.4-1.51.61.22.42.50.21.91.3-1.6
Food consumed during 24 hour testing period0.50.72.1-0.90.9-1.0-1.01.40.9-0.9-1.30.7-1.30.6-0.70.70.70.3-0.01.0-0.00.20.6
Glucose0.71.15.3-1.41.3-1.4-1.41.01.5-1.2-0.80.9-0.30.6-0.40.1-0.10.80.7-0.80.5-0.1-2.3
Heart weight0.20.41.2-0.40.6-0.1-0.20.40.2-0.6-1.10.5-0.80.5-0.60.60.90.40.21.10.70.60.4
Delay discount hyperbolic model param0.60.62.0-0.60.6-0.8-0.81.10.8-0.7-1.10.4-1.20.5-0.61.00.80.1-0.11.40.00.21.1
Intermittent access intake day 1-15 change0.71.43.9-1.71.3-2.0-1.71.21.6-1.5-1.21.1-0.50.8-0.6-0.2-0.01.10.9-0.50.60.0-1.8
Intermittent access intake escalation0.40.92.8-1.41.1-1.6-1.30.91.2-1.2-1.00.9-0.30.6-0.5-0.3-0.10.90.7-0.50.60.0-1.7
Intermittent access intake escalation 20.70.82.5-1.21.0-1.5-1.20.91.2-1.2-0.80.5-0.20.3-0.1-0.5-0.40.50.4-0.80.2-0.3-1.6
Intermitt. access day 1 inactive lever presses0.00.10.70.3-0.20.10.0-0.0-0.10.1-0.2-0.3-0.3-0.20.6-0.0-0.0-0.3-0.50.6-0.3-0.30.8
Intermitt. access day 15 inactive lever presses0.30.61.2-0.80.8-0.8-0.70.80.8-0.7-0.80.6-1.10.7-0.60.90.70.60.50.80.50.50.8
Intermitt. access escalation Index0.20.30.90.7-0.50.30.4-0.1-0.70.40.1-0.8-0.0-0.60.9-0.1-0.3-0.9-0.90.5-0.6-0.50.8
Intermittent access day 1 total infusions0.20.31.1-0.10.1-0.10.0-0.3-0.10.20.10.6-0.40.7-0.81.00.90.60.80.10.81.10.6
Intermittent access day 15 total infusions0.71.02.4-1.10.7-1.2-1.00.20.9-0.6-0.51.4-0.71.3-1.10.80.81.61.5-0.11.51.2-0.5
Intermittent access terminal intake (last 3 days)0.50.71.4-1.10.9-1.2-0.90.70.8-0.7-0.91.1-0.80.9-0.90.60.61.00.9-0.00.90.7-0.2
Intermittent access total infusions0.50.61.3-0.60.5-0.7-0.60.10.4-0.2-0.21.0-0.61.0-1.00.90.81.11.1-0.11.01.10.1
Intermittent access day 1 locomotion0.50.62.81.0-0.80.90.9-0.7-1.11.11.1-0.40.4-0.1-0.30.30.3-0.6-0.0-0.5-0.30.31.7
Intermittent access day 15 total locomotion0.20.41.7-0.80.9-0.9-0.70.80.5-0.6-0.50.60.10.4-1.3-0.20.10.20.4-0.7-0.1-0.1-0.7
Intermittent access total locomotion0.10.11.4-0.30.5-0.3-0.20.5-0.1-0.0-0.20.4-0.00.3-1.20.10.3-0.10.1-0.3-0.20.10.4
Intermittent access standard deviation1.22.55.4-2.01.7-2.3-2.21.22.3-1.8-1.01.7-0.71.6-1.40.30.51.71.8-1.21.20.7-1.9
Left kidney weight0.52.45.9-2.12.4-1.7-1.91.71.8-2.1-1.61.7-0.91.3-1.60.50.81.41.3-0.21.00.6-2.1
Right kidney weight1.14.913.6-3.03.7-2.5-2.52.92.5-3.2-2.82.2-1.61.7-2.70.81.21.51.30.31.00.5-2.3
Cocaine induced anxiety2.53.56.12.0-2.01.81.9-1.2-1.92.11.9-2.21.5-2.22.5-1.7-2.0-2.1-2.1-1.2-2.0-1.80.4
Post-drug Anxiety0.20.21.2-0.00.0-0.00.00.2-0.20.1-0.20.0-0.70.2-0.00.70.40.0-0.10.80.10.31.1
Baseline Anxiety4.85.69.6-2.22.1-1.8-1.91.91.9-2.2-2.82.5-2.82.5-2.92.93.02.11.93.12.22.31.3
Tail length1.66.310.8-2.52.1-1.6-1.71.41.7-2.1-2.03.0-2.63.0-3.03.03.22.92.92.23.03.31.0
Length with tail0.93.77.4-2.01.9-1.0-1.22.11.1-1.6-2.32.2-2.41.9-2.72.42.71.41.22.31.42.01.3
Length without tail0.41.45.5-1.31.7-0.7-0.82.30.8-1.4-2.11.0-1.30.4-1.60.61.2-0.2-0.61.3-0.40.00.4
Times rat made contact with spout0.91.03.40.9-1.40.00.2-0.4-0.21.21.0-1.20.5-1.01.9-0.7-1.4-1.0-1.1-0.8-1.3-1.30.4
Lifetime Intake0.50.61.3-0.60.4-0.6-0.50.10.3-0.2-0.31.1-0.61.0-1.10.80.91.01.10.11.01.10.1
Liver weight, left0.10.20.7-0.20.2-0.2-0.20.90.20.1-0.4-0.0-0.3-0.2-0.30.1-0.0-0.5-0.60.3-0.8-0.60.5
Liver weight, right0.30.41.4-0.71.0-1.2-1.21.11.2-0.9-0.60.4-0.40.3-0.3-0.2-0.1-0.00.0-0.3-0.3-0.5-0.4
Locomotor activity1.01.64.3-1.61.3-1.7-1.62.11.7-1.4-1.91.1-1.70.8-1.10.80.50.60.01.50.0-0.1-0.0
Locomotor testing distance1.52.77.1-2.22.0-2.3-2.22.72.3-2.2-2.41.4-1.81.0-1.40.70.60.80.31.10.1-0.2-0.6
Locomotor testing rearing3.06.113.5-3.33.0-3.6-3.53.73.7-3.1-3.32.2-2.72.0-2.21.41.11.41.01.50.60.1-0.5
Locomotion in novel chamber0.10.20.50.1-0.40.30.1-0.4-0.40.40.40.40.10.4-0.70.40.50.40.50.30.40.70.2
Locomotion in novel chamber post-restriction0.50.93.00.7-0.30.90.80.7-0.70.40.1-0.90.0-1.00.0-0.5-0.2-1.7-1.6-0.8-1.7-1.01.5
Fecal boli incidents, locomotor time 10.50.72.90.7-0.50.50.4-1.1-0.50.50.2-0.0-0.60.60.21.41.00.40.71.01.31.41.7
Change in fecal boli incidents, locomotor task0.30.30.7-0.90.4-0.7-0.70.70.7-0.6-0.40.8-0.40.6-0.80.20.30.70.60.10.20.3-0.5
Time >=10cm from walls, locomotor time 10.30.31.0-0.30.1-0.8-0.90.50.7-0.3-0.30.3-1.00.50.50.60.40.40.10.60.10.21.0
Bouts of movement, locomotor time 15.46.212.53.4-3.23.53.3-2.7-3.53.02.9-2.71.9-2.22.1-1.0-1.2-2.4-1.8-1.1-1.7-0.92.2
Total resting periods, locomotor time 15.56.112.53.4-3.23.53.3-2.8-3.53.03.0-2.62.1-2.22.0-1.0-1.2-2.3-1.7-1.2-1.6-0.81.9
Rest time, locomotor task time 12.32.96.42.5-2.32.52.3-2.3-2.32.02.3-1.71.2-1.01.50.3-0.3-1.3-0.6-0.5-0.40.22.2
Distance moved, locomotor task time 11.62.46.8-2.12.0-2.4-2.22.62.1-1.8-2.20.9-0.90.2-0.7-0.9-0.40.3-0.50.4-0.6-1.1-2.0
Vertical activity count, locomotor time 10.41.03.7-0.70.7-1.3-1.10.90.9-0.5-0.3-0.20.4-0.50.6-1.6-1.4-0.3-0.6-0.9-1.0-1.6-1.9
Time >=10cm from walls, locomotor time 20.91.34.3-1.31.3-2.0-2.11.31.9-1.5-0.81.0-1.01.2-0.40.60.50.91.00.10.50.4-0.4
Bouts of movement, locomotor time 21.32.14.92.1-2.21.81.6-1.7-1.71.91.9-1.51.0-1.01.4-0.3-0.7-1.2-0.9-0.5-1.0-0.61.5
Total resting periods, locomotor time 22.03.57.72.7-2.82.52.3-2.2-2.32.42.2-2.01.3-1.51.7-0.6-1.0-1.6-1.4-0.4-1.4-0.91.8
Rest time, locomotor task time 21.51.910.51.7-1.91.81.6-1.1-1.71.60.9-1.20.0-0.70.90.70.2-1.1-0.90.8-0.50.13.2
Distance moved, locomotor task time 21.51.85.7-1.61.8-1.8-1.72.41.8-1.8-1.30.5-0.3-0.0-0.6-1.1-0.6-0.3-0.5-0.4-1.1-1.3-1.9
Vertical activity count, locomotor time 20.91.35.9-0.10.5-0.5-0.40.20.4-0.50.4-0.71.3-0.91.0-2.0-1.7-0.6-0.6-1.8-1.1-1.7-2.4
Light reinforcement 10.10.31.8-0.00.60.10.00.30.0-0.40.1-0.30.6-0.4-0.0-0.9-0.5-0.6-0.3-1.3-0.5-0.6-0.7
Light reinforcement 20.40.72.70.6-0.11.21.0-0.7-1.00.21.1-0.81.3-0.70.5-0.9-0.6-0.7-0.1-1.7-0.3-0.2-0.6
Bone: marrow area1.22.76.0-1.81.8-1.4-1.60.71.6-1.8-0.81.9-1.12.1-1.51.71.62.02.50.12.22.0-0.5
Bone: maximum diameter1.83.45.2-2.12.3-1.8-1.92.31.9-2.2-2.02.1-2.12.0-2.12.02.11.41.41.51.21.50.6
Bone: maximum force2.24.07.4-2.62.7-2.6-2.72.22.6-2.6-1.62.2-1.42.1-1.71.41.21.82.00.31.41.1-1.3
Bone: maximum moment2.44.18.3-2.72.8-2.9-2.92.22.8-2.7-1.52.1-1.42.1-1.61.31.01.82.00.01.30.9-1.6
Mean time between licks in bursts0.51.13.3-1.41.8-1.7-1.61.81.4-1.6-1.30.7-0.90.7-0.70.20.30.30.30.10.0-0.20.2
Mean num. licks in bursts0.71.13.20.5-0.6-0.10.1-0.2-0.20.61.0-0.91.1-1.11.5-1.5-1.6-0.9-0.9-1.8-1.2-1.4-1.2
Cd content in liver0.20.31.00.5-0.90.40.4-0.9-0.30.70.6-0.30.1-0.00.70.1-0.10.20.31.00.40.30.3
Co content in liver1.11.32.7-1.41.1-1.0-1.11.61.3-1.3-1.51.1-1.61.0-0.91.11.00.80.51.10.60.70.5
Cu content in liver0.70.83.9-0.60.7-0.2-0.2-0.70.2-0.60.20.80.50.9-0.50.30.41.31.6-0.51.51.0-2.0
Fe content in liver1.61.93.61.4-1.01.61.7-1.3-1.80.91.1-1.51.9-1.61.0-1.8-1.4-1.4-1.3-1.1-1.1-1.3-1.0
K content in liver0.60.61.7-0.91.3-0.4-0.50.30.5-0.8-0.40.8-0.00.8-1.10.40.60.71.1-0.20.90.7-1.1
Mg content in liver0.60.61.6-0.81.1-0.5-0.70.20.6-0.9-0.30.7-0.00.9-0.90.50.60.81.2-0.21.10.8-1.2
Mn content in liver1.71.94.8-1.81.9-1.3-1.41.81.4-1.8-2.21.3-1.41.1-1.31.01.21.00.51.30.90.6-0.8
Na content in liver1.41.54.7-1.52.2-0.9-1.01.50.8-1.6-1.21.4-0.41.1-2.20.61.30.71.00.20.60.8-0.9
Rb content in liver2.42.83.6-1.91.5-1.6-1.81.21.6-1.8-1.91.9-1.91.9-1.41.91.81.91.61.21.91.8-0.2
Se content in liver0.50.62.30.8-1.20.60.5-0.4-0.50.90.3-0.9-0.1-0.71.2-0.2-0.5-0.7-0.90.6-0.7-0.51.5
Sr content in liver0.40.40.9-0.70.5-1.0-0.91.01.0-0.6-0.90.4-0.80.3-0.00.20.20.3-0.10.8-0.1-0.20.1
Zn content in liver0.20.21.90.3-0.30.30.1-0.2-0.10.40.70.1-0.20.4-0.40.50.5-0.00.4-0.30.00.51.4
Bone: minimum diameter0.51.02.8-1.31.7-1.1-1.11.31.1-1.5-0.71.0-0.50.9-1.20.60.70.60.9-0.00.40.5-0.9
Time in familiar zone, hab. session 12.32.25.8-1.41.2-0.9-0.90.20.8-1.1-1.01.7-1.41.9-1.11.91.82.02.11.22.42.20.4
Time in novel zone, hab. session 13.33.37.01.5-1.31.01.0-0.5-0.91.21.2-2.01.9-2.31.6-2.5-2.4-2.2-2.3-2.0-2.6-2.6-1.4
Total zone transitions, hab. session 10.40.63.2-0.90.9-1.1-1.11.81.0-0.9-0.60.4-0.80.2-0.30.40.2-0.3-0.30.4-0.7-0.30.7
Total locomotion distance, hab. session 10.91.34.3-1.61.9-1.6-1.62.11.6-1.6-1.30.8-0.80.5-0.40.30.20.30.10.5-0.1-0.3-0.9
Locomotion velocity, hab. session 10.50.72.4-1.21.6-1.2-1.21.51.2-1.3-0.70.6-0.50.5-0.30.30.20.20.20.4-0.1-0.1-0.6
Time in familiar zone, hab. session 23.94.16.92.4-1.62.42.4-1.4-2.51.82.5-2.32.3-2.11.6-1.7-1.4-2.6-1.8-2.1-2.1-1.41.1
Time in novel zone, hab. session 22.72.84.8-1.91.2-1.8-1.81.01.9-1.4-2.01.9-1.91.8-1.41.51.32.21.61.81.91.4-0.6
Total zone transitions, hab. session 20.20.31.2-0.40.5-0.2-0.21.10.2-0.4-0.60.2-0.6-0.0-0.40.30.4-0.3-0.51.0-0.6-0.10.7
Total locomotion distance, hab. session 20.20.31.10.10.20.40.40.4-0.40.0-0.2-0.50.4-0.80.6-0.5-0.5-0.7-1.10.1-0.8-0.8-0.7
Locomotion velocity, hab. session 20.30.41.20.10.20.40.40.3-0.4-0.0-0.1-0.50.5-0.90.6-0.7-0.7-0.8-1.0-0.2-0.9-1.0-1.1
Novel to familiar place preference ratio0.20.21.60.1-0.30.30.20.5-0.30.6-0.20.1-0.6-0.0-0.50.40.6-0.3-0.40.6-0.40.21.2
Novelty place preference0.20.31.40.4-0.70.60.50.1-0.50.90.2-0.1-0.3-0.3-0.20.10.3-0.5-0.50.3-0.60.01.2
Time in novel zone, NPP test0.30.31.80.5-0.70.50.50.1-0.50.90.3-0.2-0.3-0.2-0.20.10.3-0.5-0.50.4-0.60.11.4
Total zone transitions, NPP test0.20.32.70.2-0.20.30.30.4-0.40.1-0.0-0.1-0.5-0.10.10.60.5-0.4-0.51.3-0.30.21.6
Total locomotion distance, NPP test0.20.31.3-0.70.9-0.3-0.41.00.3-0.8-0.80.3-0.60.2-0.10.50.40.1-0.21.1-0.00.1-0.0
Locomotion velocity, NPP test0.40.61.7-1.01.3-0.6-0.61.30.6-1.1-1.20.6-0.70.3-0.30.40.50.3-0.11.00.10.1-0.5
Intraocular pressure0.20.31.3-0.4-0.1-0.9-0.80.70.9-0.1-0.20.2-0.80.40.10.50.10.10.00.4-0.2-0.11.1
Delta distance traveled before/after self-admin0.30.31.7-0.60.4-0.7-0.6-0.10.7-0.3-0.50.3-0.00.20.1-0.3-0.30.80.50.00.7-0.0-1.3
Delta ambulatory time before/after self-admin1.21.53.2-1.51.3-1.8-1.70.81.8-1.3-1.41.2-0.91.1-0.70.40.41.41.10.61.20.6-1.2
Parametrial fat weight3.78.812.93.0-3.02.52.6-2.7-2.73.13.5-3.43.4-3.23.6-3.3-3.5-2.8-2.3-3.3-2.6-2.8-0.7
Pavlov. Cond. lever latency0.60.72.70.7-0.30.60.6-1.4-0.60.31.6-0.61.6-0.20.4-0.7-0.7-0.20.6-1.40.2-0.1-1.1
Pavlov. Cond. magazine entry latency0.30.40.9-0.50.5-0.1-0.10.10.0-0.3-0.60.7-0.70.7-0.70.80.90.80.70.40.90.90.0
Pavlov. Cond. change in total contacts0.60.62.3-0.90.4-0.6-0.50.60.6-0.5-1.31.0-1.00.7-0.70.50.81.00.41.50.80.7-0.4
Pavlov. Cond. index score0.81.13.1-1.11.0-0.7-0.71.20.7-0.9-1.81.1-1.60.8-1.11.11.20.90.21.30.70.80.3
Pavlov. Cond. latency score1.01.23.6-1.10.9-0.8-0.81.40.8-0.8-1.91.1-1.90.8-1.01.21.30.80.11.70.60.80.8
Pavlov. Cond. lever contacts0.40.52.0-0.50.3-0.2-0.31.20.2-0.3-1.40.5-1.30.1-0.60.50.80.0-0.71.1-0.20.11.0
Pavlov. Cond. magazine entry number0.40.61.40.8-0.80.40.3-0.2-0.30.51.1-0.90.7-0.70.8-0.5-0.7-1.2-0.7-0.5-1.1-0.81.0
Pavlov. Cond. intertrial magazine entries1.72.03.0-1.51.5-1.5-1.51.41.6-1.7-1.41.4-1.51.6-1.21.51.41.21.31.71.21.20.5
Pavlov. Cond. lever-magazine prob. diff.0.60.82.1-0.90.9-0.5-0.51.00.5-0.7-1.51.0-1.30.7-1.20.91.10.70.21.00.60.70.2
Pavlov. Cond. response bias0.30.41.2-0.70.6-0.3-0.30.20.2-0.3-1.10.8-0.80.5-0.70.60.70.90.40.70.90.7-0.5
Pavlov. Cond. lever latency1.92.55.71.8-1.31.91.9-2.3-1.81.42.2-1.52.4-1.41.4-1.6-1.5-1.0-0.5-1.8-0.5-0.9-1.2
Pavlov. Cond. magazine entry latency0.70.83.10.0-0.40.40.3-0.1-0.30.30.00.8-0.80.8-1.11.41.50.50.71.00.81.51.8
Pavlov. Cond. change in total contacts1.11.73.0-1.31.0-1.2-1.21.11.0-1.0-1.51.5-1.61.4-1.51.61.61.31.01.71.21.40.5
Pavlov. Cond. index score0.91.22.9-0.80.4-0.6-0.71.00.5-0.5-1.01.1-1.51.1-1.31.51.60.70.61.70.71.31.7
Pavlov. Cond. latency score0.60.82.7-0.50.1-0.3-0.30.60.2-0.2-0.70.9-1.30.9-1.01.41.50.60.41.50.61.21.6
Pavlov. Cond. lever contacts2.02.76.2-1.81.3-1.8-1.82.31.7-1.4-2.21.5-2.51.4-1.41.81.61.00.52.10.61.01.4
Pavlov. Cond. magazine entry number0.50.71.9-0.60.8-1.1-1.00.81.1-0.8-0.4-0.30.1-0.30.7-0.9-1.1-0.2-0.4-0.8-0.6-1.3-1.4
Pavlov. Cond. intertrial magazine entries0.81.33.2-1.51.8-1.7-1.61.61.6-1.7-1.40.7-0.50.5-0.4-0.3-0.20.60.3-0.10.1-0.5-1.7
Pavlov. Cond. lever-magazine prob. diff.0.70.92.1-0.70.3-0.5-0.50.80.4-0.4-0.91.0-1.31.0-1.11.31.40.70.61.50.71.21.4
Pavlov. Cond. response bias1.62.24.5-1.51.1-1.5-1.51.81.4-1.2-1.71.5-2.11.5-1.61.71.71.00.81.60.71.21.5
Time in closed arm before self-admin0.10.10.4-0.20.20.1-0.1-0.00.1-0.4-0.10.4-0.30.5-0.40.50.50.50.5-0.00.50.60.0
Time in closed arm after self-admin0.10.10.2-0.10.30.20.1-0.1-0.2-0.30.20.20.30.2-0.5-0.00.10.20.4-0.20.20.2-0.5
Time in open arm before self-admin1.41.53.51.6-1.91.71.7-1.7-1.71.81.2-1.01.1-1.11.3-0.6-0.5-0.7-0.80.3-0.3-0.20.3
Time in open arm after self-admin0.30.42.70.6-0.50.20.30.1-0.20.7-0.1-0.6-0.4-0.40.40.1-0.1-0.7-0.80.9-0.7-0.51.6
Bone: periosteal estimation2.14.57.2-2.62.7-2.2-2.42.12.4-2.6-1.82.4-2.02.4-2.22.12.02.02.20.91.81.8-0.3
Bone: periosteal perimeter3.05.19.8-2.93.1-2.4-2.62.72.6-3.0-2.52.5-2.12.3-2.42.02.01.81.71.01.61.4-0.8
Bone: post-yield work0.91.32.3-1.41.4-1.2-1.21.21.2-1.4-1.11.2-0.91.3-1.51.21.10.91.10.40.90.9-0.3
Progressive ratio test 1 active lever presses1.01.33.0-1.01.0-1.0-0.91.00.9-0.8-1.21.4-1.31.3-1.71.21.51.00.91.00.81.10.8
Progressive ratio test 1 breakpoint1.01.33.2-1.01.0-0.9-0.90.90.8-0.8-1.21.4-1.31.3-1.81.31.61.00.91.00.91.20.8
Progressive ratio test 1 inactive lever presses0.30.51.3-0.60.7-0.8-0.81.20.7-0.6-0.80.6-1.00.5-1.00.60.70.10.00.5-0.20.21.0
Progressive ratio test 2 active lever presses1.31.53.1-0.90.9-0.8-0.80.30.6-0.7-0.81.5-1.11.5-1.61.51.71.51.51.11.61.81.0
Progressive ratio test 2 breakpoint1.31.53.0-1.00.9-0.8-0.80.40.6-0.7-0.81.4-1.11.5-1.61.51.71.41.51.21.61.71.0
Progressive ratio test 2 inactive lever presses1.93.15.6-1.41.4-1.4-1.50.51.3-1.1-1.22.0-1.82.2-1.72.22.22.22.21.72.32.41.2
Incentive Sensitization - Responses0.91.22.9-0.80.7-0.7-0.60.20.4-0.5-0.51.2-1.01.4-1.01.51.51.31.41.21.51.71.2
Incentive Sensitization - Breakpoint0.91.12.7-0.70.8-0.7-0.60.20.5-0.6-0.51.1-1.01.3-0.91.51.41.21.31.11.51.61.2
Sum of active levers in priming session hrs 5-60.50.51.60.9-1.10.90.9-1.2-0.91.10.4-0.50.7-0.60.5-0.6-0.4-0.2-0.30.5-0.0-0.2-0.2
Progressive ratio0.20.31.30.1-0.20.40.30.2-0.50.1-0.00.5-0.40.4-1.10.80.90.00.10.4-0.10.61.0
Food seeking constrained by brief footshock0.40.51.90.7-0.80.80.8-1.4-1.00.81.1-0.11.0-0.10.1-0.1-0.20.20.5-0.80.50.5-0.6
Seeking ratio, punishment vs. effort0.20.32.00.1-0.1-0.00.1-0.6-0.10.10.4-0.40.8-0.40.7-0.9-0.9-0.00.0-0.90.1-0.4-1.4
Retroperitoneal fat weight3.916.425.03.9-3.33.63.6-2.5-3.73.44.0-4.54.6-4.73.9-5.0-4.6-4.6-4.0-4.9-4.5-4.5-1.6
Reaction time number correct0.40.81.9-0.81.1-1.3-1.31.31.4-0.8-0.60.0-0.0-0.20.2-1.1-1.0-0.3-0.5-0.7-0.9-1.3-1.0
Reaction time mean minus median0.61.55.21.7-1.41.51.6-2.3-1.71.62.2-0.91.5-0.40.7-0.2-0.4-0.20.4-1.00.20.30.3
Reaction time mean minus median AUC1.33.48.42.4-2.22.02.1-2.7-2.22.32.9-1.82.3-1.41.8-1.2-1.5-1.0-0.5-1.6-0.7-0.7-0.0
Reaction time num false alarms3.65.111.9-2.82.7-3.4-3.42.13.5-2.7-1.72.2-1.92.4-1.41.51.12.32.4-0.21.81.2-1.0
Reaction time num false alarms AUC3.96.113.9-3.02.7-3.7-3.72.03.7-2.8-1.92.5-2.12.7-1.51.81.32.72.7-0.12.21.5-1.0
Reaction time trials correct on left0.40.81.9-0.81.1-1.3-1.31.31.4-0.8-0.60.0-0.0-0.20.2-1.1-1.0-0.3-0.5-0.7-0.9-1.3-1.0
Reaction time trials on left0.40.82.0-0.81.1-1.4-1.31.31.4-0.8-0.60.0-0.0-0.20.1-1.1-1.0-0.2-0.4-0.7-0.9-1.3-1.1
Reaction time mean2.13.411.52.3-2.02.52.6-3.4-2.72.42.9-1.32.3-0.91.2-0.4-0.6-0.40.4-1.30.50.50.2
Reaction time mean AUC2.54.012.32.6-2.32.72.7-3.5-2.92.53.1-1.62.4-1.11.5-0.6-0.8-0.80.1-1.40.20.30.5
Median of all reaction times2.23.110.82.2-1.92.52.6-3.3-2.72.32.6-1.32.2-0.91.2-0.5-0.5-0.40.3-1.10.60.60.1
Reaction time omissions0.30.41.60.7-0.50.40.4-1.3-0.50.71.2-0.40.80.00.60.2-0.20.10.6-0.80.50.3-0.0
Reaction time false alarm rate2.83.96.2-2.21.9-2.4-2.51.22.5-2.0-1.42.1-1.92.4-1.32.11.62.32.50.42.31.9-0.2
Reaction time premature initiation rate0.10.10.60.2-0.30.30.2-0.2-0.40.20.50.0-0.00.2-0.20.30.30.10.3-0.10.10.30.8
Reaction time premature initiations0.10.10.4-0.30.3-0.6-0.60.50.5-0.30.20.1-0.10.1-0.1-0.3-0.3-0.00.1-0.6-0.4-0.30.1
Std. dev. reaction times0.81.66.61.6-1.31.31.4-2.6-1.51.52.3-0.71.5-0.10.70.1-0.30.20.9-1.30.70.60.1
Reaction time trials completed0.40.82.0-0.81.1-1.4-1.31.31.4-0.8-0.60.0-0.0-0.20.1-1.1-1.0-0.2-0.4-0.7-0.9-1.3-1.1
Reaction time trials AUC0.51.02.5-1.01.2-1.5-1.51.51.6-0.9-0.80.2-0.1-0.10.1-1.1-0.9-0.1-0.4-0.6-0.8-1.2-1.2
Run reversals in cocaine runway, females0.40.42.10.20.10.10.10.30.1-0.30.5-0.50.6-0.50.3-0.8-0.7-0.7-0.5-1.5-1.0-0.9-0.5
Run reversals in cocaine runway, males1.91.94.11.0-0.71.21.2-1.0-1.00.91.4-1.32.0-1.61.5-1.9-1.7-1.3-1.1-2.0-1.1-1.3-1.4
Latency to leave start box in cocaine runway0.30.31.10.5-0.50.70.7-0.1-0.60.30.4-0.70.3-0.71.0-0.4-0.3-0.7-0.8-0.5-0.5-0.30.6
Latency to leave start box in cocaine runway, F0.10.20.9-0.00.10.40.30.6-0.3-0.2-0.5-0.2-0.4-0.30.20.30.4-0.5-0.70.1-0.30.10.9
Latency to leave start box in cocaine runway, M1.71.63.31.3-1.41.21.2-1.3-1.11.21.7-1.51.5-1.31.8-1.3-1.5-1.0-0.9-1.0-0.9-1.0-0.0
Std. dev. time between licks in bursts1.31.83.3-1.51.3-1.6-1.71.51.6-1.1-1.71.3-1.81.4-1.21.21.11.10.91.50.90.80.9
Total sessions with >9 infusions0.20.31.30.1-0.3-0.1-0.0-0.1-0.20.40.40.6-0.30.6-1.00.80.80.40.60.10.20.81.1
Short access day 1 total inactive lever presses0.00.10.4-0.20.3-0.10.10.1-0.2-0.10.00.40.10.1-0.7-0.20.00.20.10.1-0.1-0.0-0.6
Short access day 10 total inactive lever presses0.00.10.3-0.00.2-0.2-0.2-0.40.1-0.20.20.10.20.2-0.2-0.0-0.00.30.5-0.10.40.2-0.3
Short access day 1 total infusions0.20.30.80.6-0.60.60.6-0.7-0.80.90.9-0.00.6-0.1-0.4-0.3-0.1-0.10.1-0.9-0.20.10.2
Short access day 10 total infusions0.50.72.3-0.70.8-0.7-0.70.90.5-0.5-0.71.0-0.80.9-1.50.81.20.50.60.40.30.80.8
Short access total infusions0.10.10.40.2-0.30.10.2-0.5-0.40.60.50.40.20.3-0.60.10.40.30.5-0.30.30.60.2
Short access day 1 locomotion0.10.10.70.3-0.10.10.1-0.0-0.40.30.40.10.20.1-0.80.20.3-0.30.0-0.7-0.30.10.6
Short access day 10 total locomotion0.10.21.50.4-0.20.10.1-0.2-0.30.40.70.00.10.2-0.40.20.3-0.30.2-0.4-0.20.21.2
Short access total locomotion0.30.41.80.1-0.0-0.2-0.20.0-0.00.20.60.6-0.10.8-1.10.70.80.20.8-0.50.10.71.3
One hour access (0.3 mA shock)3.33.86.0-2.01.7-2.3-2.21.52.0-1.6-1.62.1-2.32.3-1.82.52.11.91.91.51.92.01.3
Compulsive drug intake0.30.41.50.8-0.90.50.4-1.2-0.40.71.1-0.50.9-0.30.8-0.5-0.5-0.10.2-0.50.1-0.0-0.3
One hour access (shock baseline)0.81.22.3-1.21.2-1.2-1.11.41.0-0.9-1.21.1-1.51.1-1.11.51.20.70.61.00.60.91.1
Social response proportion0.70.83.11.0-1.11.31.2-1.8-1.21.41.3-0.40.8-0.20.60.0-0.10.30.5-0.00.70.70.1
Social responses3.54.57.3-2.42.2-1.7-1.81.31.7-2.0-1.92.7-1.72.5-2.62.12.32.52.51.52.52.4-0.9
Social time1.11.54.6-0.70.3-1.1-1.2-0.41.0-0.10.11.4-0.91.7-0.81.41.11.92.10.91.91.70.4
Soleus weight0.20.52.3-0.70.8-1.0-1.00.60.9-0.8-0.00.30.30.2-0.2-0.5-0.40.10.4-1.1-0.2-0.5-1.5
Bone: stiffness4.26.910.5-3.23.1-2.9-3.02.13.0-2.9-2.13.2-2.13.0-2.72.32.23.03.00.92.62.3-1.4
Tibialis anterior weight0.10.21.00.3-1.00.00.1-0.4-0.30.80.1-0.1-0.5-0.10.40.3-0.00.2-0.20.70.10.10.7
Time to tail flick, vehicle, before self-admin0.60.71.8-0.40.4-0.7-0.5-0.10.7-0.60.00.9-0.51.2-0.51.11.11.01.30.01.21.30.6
Time to tail flick, vehicle, after self-admin2.53.35.62.2-2.41.92.3-2.4-1.92.22.0-2.11.8-1.82.1-1.4-1.9-1.3-1.1-1.3-0.9-1.2-0.4
Time to tail flick, test, before self-admin0.70.72.20.5-0.70.50.7-0.5-0.30.80.8-0.90.9-1.01.0-1.3-1.5-0.6-0.6-1.1-0.7-1.1-0.7
Time to tail flick, test, after self-admin0.10.10.7-0.0-0.10.20.10.1-0.00.00.1-0.20.3-0.40.1-0.6-0.6-0.2-0.3-0.2-0.5-0.6-0.8
Delta time to tail flick, vehicle, before/after SA1.51.42.71.1-1.31.21.5-0.8-1.21.30.2-1.50.7-1.71.5-1.1-1.5-1.1-1.60.3-1.0-1.4-0.4
Delta time to tail flick, test, before/after SA0.10.10.20.4-0.30.50.2-0.3-0.50.20.2-0.10.0-0.10.20.20.3-0.1-0.10.20.00.20.2
Tibia length3.18.517.6-3.33.9-2.3-2.54.22.3-3.6-3.83.0-3.52.6-3.42.93.71.51.12.81.42.21.7
Ambulatory time before self-admin0.71.13.4-1.11.3-0.7-1.01.60.7-1.1-1.11.1-1.10.9-1.81.01.30.20.41.00.10.60.7
Ambulatory time after self-admin2.32.74.4-2.12.0-1.8-2.11.61.8-1.7-1.71.9-1.41.7-2.11.21.31.61.51.31.31.1-0.5
Bone: tissue strength0.40.41.0-0.70.8-1.0-1.00.81.0-0.8-0.30.3-0.00.2-0.2-0.3-0.30.20.2-0.6-0.2-0.4-1.0
Total heroin consumption0.50.61.61.0-0.91.21.2-1.0-1.11.00.7-0.50.9-0.70.0-0.8-0.3-0.5-0.50.2-0.5-0.4-0.4
Bone: trabecular number0.91.43.21.3-1.41.51.6-0.5-1.71.40.4-1.30.4-1.41.0-0.7-0.4-1.5-1.80.4-1.1-0.71.4
Bone: trabecular spacing0.60.82.1-1.10.9-1.3-1.40.91.5-0.9-0.31.0-0.61.0-0.90.40.40.81.0-0.30.30.4-0.3
Bone: trabecular thickness0.10.10.40.4-0.20.60.6-0.3-0.60.20.1-0.50.3-0.40.4-0.1-0.3-0.5-0.4-0.1-0.2-0.30.0
Bone: trabecular tissue density0.30.41.2-0.90.9-0.5-0.60.70.6-0.7-0.80.8-0.30.5-1.00.20.40.50.50.50.40.3-1.1
Water consumed over 24 hours1.72.34.7-1.51.4-1.4-1.52.11.4-1.3-2.01.6-2.21.4-1.71.91.80.90.52.10.61.01.1
Number of responses in last shaping day0.40.41.30.9-0.91.11.1-0.8-1.10.90.5-0.30.1-0.30.10.10.1-0.2-0.30.5-0.10.10.8