Hub : Genes

Cobll1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Cobll1 0.09 0.04 3.5e-11 0.05 0.08 0.08 0.08 2.1e-06 2.7e-09 1.4e-09 1.7e-09
2 pVTA gene expression Cobll1 0.17 0.1 3.2e-05 0.14 0.1 0.11 0.12 1.3e-06 6.2e-05 2.0e-05 4.9e-06
3 Brain gene expression Cobll1 0.04 0.02 1.3e-04 0.04 0.04 0.03 0.04 1.2e-04 1.6e-04 7.9e-04 2.1e-04
4 BLA gene expression Cobll1 0.08 0.04 1.1e-03 0.03 0.05 0.04 0.04 1.6e-02 1.2e-03 4.5e-03 5.1e-03
5 PL gene expression Cobll1 0.09 0.04 1.5e-06 0.06 0.05 0.04 0.05 3.3e-07 1.3e-06 1.2e-05 1.7e-06
6 Adipose gene expression Cobll1 0.41 0.1 0.0e+00 0.12 0.14 0.13 0.12 1.7e-13 4.2e-15 4.4e-14 4.4e-13
7 BLA mRNA stability Cobll1 0.23 0.08 7.4e-10 0.18 0.17 0.18 0.19 7.9e-10 1.2e-09 6.3e-10 2.0e-10
8 PL isoform ratio XM_039106337.1 0.05 0.03 2.9e-04 0.03 0.04 0.06 0.04 1.7e-04 3.6e-05 3.6e-07 1.2e-05
9 NAcc mRNA stability Cobll1 0.12 0.05 1.5e-13 0.09 0.13 0.12 0.13 4.8e-11 8.0e-15 3.1e-14 1.9e-14
10 OFC mRNA stability Cobll1 0.49 0.13 4.4e-06 0.19 0.22 0.19 0.24 3.5e-05 6.3e-06 3.5e-05 1.9e-06
11 IL mRNA stability Cobll1 0.48 0.11 4.1e-08 0.21 0.34 0.36 0.35 1.1e-05 3.9e-09 1.7e-09 2.2e-09
12 Brain mRNA stability Cobll1 0.5 0.08 0.0e+00 0.33 0.44 0.44 0.46 8.7e-32 4.3e-45 5.9e-45 3.6e-47
13 PL mRNA stability Cobll1 0.36 0.1 0.0e+00 0.2 0.27 0.27 0.27 1.5e-21 8.9e-30 5.7e-30 4.7e-30
14 Adipose intron excision ratio chr3_49811034_49812075 0.05 0.03 1.8e-03 0.01 0 0 0.01 1.6e-02 1.2e-01 1.5e-01 6.7e-02
15 pVTA mRNA stability Cobll1 0.17 0.08 1.3e-04 0.1 0.06 0.05 0.1 5.1e-05 9.2e-04 2.4e-03 6.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.71.7-0.0-1.3-1.31.2-0.51.0-0.61.3-1.2-0.40.0-0.5-0.3-0.80.8
Area under the delay curve0.30.40.90.8-0.8-0.80.4-1.00.40.20.7-0.1-0.70.7-0.5-0.30.60.0
BMI with tail0.31.02.2-0.7-0.30.21.1-0.50.8-0.91.4-1.3-0.91.1-1.5-1.30.21.4
BMI without tail0.10.10.50.6-0.00.4-0.10.10.6-0.30.20.4-0.20.20.20.1-0.4-0.7
Body weight0.20.92.5-1.50.10.9-0.11.6-1.51.10.3-0.80.8-0.6-0.00.4-0.91.1
Weight adjusted by age0.70.81.80.3-0.8-0.91.1-0.81.4-1.31.0-0.9-0.70.7-0.7-0.9-0.10.3
Bone surface0.10.10.5-0.7-0.4-0.10.20.30.00.20.4-0.20.2-0.60.10.2-0.30.1
Bone volume0.10.20.5-0.5-0.5-0.40.40.20.30.10.4-0.50.1-0.40.00.2-0.70.3
Breakpoint value in progressive ratio session1.92.15.52.3-1.9-2.01.3-1.91.0-0.82.0-0.7-1.61.2-1.1-0.90.8-0.0
Number of licking bursts0.40.52.3-0.6-0.10.6-0.10.7-0.10.0-0.1-0.10.8-1.20.90.8-1.5-0.1
Context. condit. distance diff. score0.30.41.80.3-0.9-0.40.30.8-0.40.30.5-0.70.7-0.20.50.6-1.40.5
Locomotion velocity, session 10.80.82.60.1-0.4-0.70.6-0.90.1-0.90.9-0.5-1.01.2-1.3-1.31.60.7
Locomotion distance, session 10.10.21.2-0.6-0.4-1.10.40.00.2-0.20.6-0.30.00.1-0.1-0.10.10.3
Locomotion velocity, session 20.70.82.10.4-0.1-0.60.4-1.51.4-0.80.80.2-1.31.0-0.8-0.91.0-0.1
Locomotion distance, session 20.70.95.1-2.31.10.3-1.00.9-0.71.2-0.40.91.0-0.80.70.80.3-0.4
Locomotion velocity, session 30.50.61.30.2-1.0-1.11.0-0.60.8-1.01.2-0.9-0.60.5-0.7-0.7-0.10.8
Locomotion distance, session 30.10.10.4-0.1-0.5-0.3-0.10.2-0.50.20.70.20.2-0.50.40.40.1-0.5
Stereotopy head waving bouts, day 32.32.75.5-2.31.11.5-1.22.1-1.31.8-1.10.42.3-2.11.71.8-1.9-0.1
Stereotopy head waving duration, day 31.51.83.7-1.71.11.2-1.01.8-1.01.2-1.10.31.9-1.61.41.4-1.70.0
Locomotion velocity, session 70.40.51.4-0.30.90.7-0.90.3-0.30.3-0.61.20.1-0.40.60.40.8-1.2
Locomotion distance, session 70.40.61.1-0.70.90.6-1.00.9-1.00.7-0.40.90.6-0.80.80.60.2-0.8
Stereotopy head waving bouts, day 70.91.03.1-1.0-0.4-0.2-0.31.0-0.51.00.30.11.6-1.81.31.4-1.6-0.4
Stereotopy head waving duration, day 71.01.23.7-0.6-0.40.0-0.41.1-0.91.0-0.00.31.7-1.91.51.5-1.6-0.7
Locomotion velocity, session 80.10.10.40.20.1-0.1-0.40.3-0.20.3-0.10.50.5-0.10.50.40.0-0.6
Locomotion distance, session 80.40.61.7-0.8-0.7-0.70.21.1-0.50.70.5-0.61.0-0.60.60.8-1.30.6
Degree of sensitization distance0.40.42.0-0.30.40.0-0.40.9-0.40.5-0.7-0.10.8-0.70.80.8-1.40.2
Degree of sensitization stereotypy0.60.72.60.1-1.6-1.51.0-0.60.6-0.01.2-1.00.1-0.4-0.10.1-1.10.5
Conditioned locomotion0.60.72.9-0.30.0-0.3-0.30.80.10.6-0.40.21.2-1.31.21.1-1.7-0.7
Cocaine response after cond. corrected1.41.62.71.0-1.4-1.61.5-1.01.3-1.31.5-1.6-0.91.0-1.0-1.0-0.71.3
Cocaine response after cond. not corrected0.10.21.0-0.1-0.2-0.30.10.5-0.00.20.2-0.40.6-0.20.40.4-1.00.3
Cocaine response before conditioning4.55.58.3-1.92.02.4-2.62.9-2.52.8-2.12.12.7-2.42.72.7-0.8-1.8
Saline control response1.01.44.6-0.3-0.9-0.81.4-0.61.1-1.00.4-1.9-0.91.3-1.4-1.2-0.62.1
Bone: connectivity density0.71.02.80.1-1.7-1.41.4-0.50.7-0.71.6-1.5-0.5-0.1-0.7-0.5-0.71.0
Bone: cortical apparent density0.50.61.9-0.1-0.5-0.91.1-0.30.3-1.10.5-1.3-0.40.3-0.9-1.0-0.11.4
Bone: cortical area1.62.45.2-2.32.01.6-1.72.1-1.61.8-1.71.01.8-1.01.11.3-0.2-0.2
Bone: cortical porosity1.11.22.8-0.50.30.6-1.11.1-1.41.7-0.51.01.3-1.31.41.4-0.3-1.3
Bone: cortical porosity1.11.22.6-0.80.61.2-1.21.3-1.61.5-0.81.01.3-1.11.21.10.1-1.0
Bone: cortical thickness0.30.52.9-1.70.90.4-0.30.7-0.40.7-0.6-0.30.7-0.0-0.10.1-0.41.0
Bone: cortical thickness1.41.73.4-1.51.10.8-1.21.7-1.31.8-1.40.51.7-1.11.31.4-1.2-0.2
Bone: cortical tissue density0.60.82.00.0-0.7-1.11.2-0.50.4-1.20.7-1.3-0.60.4-1.0-1.1-0.11.4
Condit. Reinf. active minus inactive responses1.92.14.3-2.11.11.1-1.31.9-1.51.6-0.60.91.6-2.01.61.6-0.9-0.8
Condit. Reinf. active-inactive response ratio0.70.81.7-1.30.70.5-0.81.2-0.91.0-0.40.50.9-1.20.91.0-0.6-0.4
Condit. Reinf. active responses2.63.25.0-2.11.72.0-1.92.2-1.91.6-1.01.61.8-2.22.01.8-0.5-1.5
Condit. Reinf. inactive responses1.61.94.3-1.21.62.1-1.61.5-1.50.8-0.91.61.3-1.51.41.00.4-1.5
Incentive salience index mean1.82.14.2-2.01.11.1-1.31.8-1.71.7-0.61.01.6-2.01.61.6-0.7-0.9
Condit. Reinf. lever presses0.20.30.9-0.90.40.4-0.40.8-1.00.6-0.00.10.7-0.80.40.5-0.20.1
Condit. Reinf. active minus inactive responses1.92.47.7-2.81.81.9-1.52.2-1.61.5-1.60.71.5-1.01.11.1-0.3-0.0
Condit. Reinf. active-inactive response ratio1.01.03.7-1.91.51.1-1.11.4-0.70.8-1.20.70.9-0.60.70.60.0-0.2
Condit. Reinf. active responses2.33.28.2-2.91.92.3-1.72.6-2.11.8-1.90.71.8-1.41.31.3-0.60.0
Condit. Reinf. inactive responses0.70.92.1-1.10.61.2-0.71.4-1.11.0-0.9-0.11.0-0.80.70.9-1.20.4
Condit. Reinf. lever presses3.24.49.3-3.02.32.4-2.03.0-1.81.8-2.41.02.2-1.91.91.9-1.5-0.3
Condit. Reinf. lever reinforcers received1.52.16.8-2.61.82.1-1.42.1-1.51.2-1.70.51.2-0.80.80.8-0.30.3
Conditioned reinforcement - actives0.60.61.4-0.10.5-0.0-0.71.0-0.90.9-0.40.71.0-0.91.11.2-0.6-0.7
Conditioned reinforcement - inactives0.30.40.7-0.30.70.4-0.70.4-0.80.6-0.10.80.3-0.50.50.50.9-0.8
Conditioned locomotion0.20.31.40.20.1-0.2-0.60.5-1.20.8-0.20.40.3-0.20.40.9-0.0-0.1
Patch foraging indifference point 0 sec0.71.15.2-0.7-1.0-1.01.10.40.3-0.60.4-1.50.4-0.90.20.1-2.31.7
Patch foraging indifference point AUC1.11.34.90.11.21.1-1.50.3-0.10.7-1.12.20.4-0.31.10.81.1-2.1
Delay disc. indifference point, 0s delay0.40.41.6-0.20.40.20.2-0.2-0.6-0.1-0.4-0.4-0.60.6-0.8-1.11.30.9
Delay disc. indifference point, 16s delay0.20.20.70.3-0.4-0.5-0.1-0.4-0.20.80.40.40.0-0.40.40.6-0.2-0.6
Delay disc. indifference point, 2s delay1.01.15.7-0.60.60.40.2-1.30.4-0.60.50.4-1.51.1-1.3-1.42.4-0.2
Delay disc. indifference point, 24s delay0.40.41.00.9-0.9-0.7-0.2-0.3-0.51.00.50.60.4-0.40.70.8-0.1-0.8
Delay disc. indifference point, 4s delay2.52.75.41.1-1.2-0.91.5-2.01.2-0.91.2-1.1-2.32.3-2.2-2.02.11.1
Delay disc. indifference point, 8s delay0.20.20.70.6-0.6-0.80.2-0.70.60.50.4-0.1-0.40.6-0.20.1-0.1-0.0
Indifference point function ln k0.10.10.4-0.50.00.10.20.5-0.5-0.10.1-0.60.2-0.5-0.10.0-0.40.4
Indifference point function log k0.10.10.4-0.50.00.10.20.5-0.5-0.10.1-0.60.2-0.5-0.10.0-0.40.4
Patch foraging total patch changes 0 sec1.01.64.7-0.4-1.6-1.61.6-0.10.7-1.10.9-2.0-0.0-0.5-0.3-0.3-2.22.1
Patch foraging total patch changes 12 sec0.50.71.7-0.70.70.6-0.90.7-0.91.0-1.31.01.0-0.90.90.80.1-0.4
Patch foraging total patch changes 18 sec0.91.22.6-0.70.80.6-1.11.0-0.40.9-0.91.41.2-1.51.61.5-0.8-1.2
Patch foraging total patch changes 24 sec0.81.02.7-1.61.10.6-0.71.3-0.40.7-1.30.21.1-0.90.90.8-1.60.5
Patch foraging total patch changes 6 sec0.20.31.6-0.1-0.8-0.80.5-0.10.6-0.40.2-0.30.2-0.70.50.3-1.30.4
Patch foraging time to switch 0 sec0.30.51.30.7-1.0-0.80.9-0.70.3-0.20.6-1.1-0.40.5-0.7-0.6-0.50.9
Patch foraging water rate 0 sec1.72.74.8-2.01.31.3-1.71.9-2.21.8-1.11.41.8-2.11.71.8-0.4-0.8
Patch foraging water rate 12 sec0.91.43.1-1.61.81.7-1.41.0-1.41.1-1.51.20.8-0.70.50.60.8-0.5
Patch foraging water rate 18 sec0.50.72.2-1.41.10.8-0.50.4-1.10.6-0.60.2-0.30.5-0.6-0.51.50.9
Patch foraging water rate 24 sec0.00.10.3-0.60.5-0.3-0.10.00.3-0.1-0.40.1-0.30.1-0.1-0.10.00.2
Patch foraging water rate 6 sec0.91.43.2-1.41.41.3-1.51.3-1.81.3-1.11.10.9-1.00.80.80.6-0.3
Seeking ratio, delayed vs. immediate footshock0.40.50.7-0.50.80.8-0.70.8-0.40.9-0.60.50.7-0.80.70.7-0.5-0.7
Distance traveled before self-admin2.32.46.5-1.51.21.2-1.62.1-2.62.1-1.11.01.7-1.71.51.6-0.4-0.6
Distance traveled after self-admin2.73.05.9-1.32.11.9-2.21.7-2.41.8-2.12.11.2-1.31.51.31.0-1.3
Extensor digitorum longus weight0.31.14.1-2.02.02.0-0.90.60.00.1-1.60.70.3-0.10.0-0.00.50.1
Bone: elastic displacement0.60.71.4-0.3-0.2-0.30.8-1.01.1-0.80.6-0.8-0.81.0-1.2-1.20.11.0
Bone: elastic work1.72.25.9-1.50.2-0.21.4-0.72.1-1.70.7-1.8-1.11.8-1.9-1.9-0.22.4
Bone: endosteal estimation1.32.85.5-0.51.92.0-2.21.7-1.21.6-2.02.31.3-0.91.91.70.5-2.2
Bone: endosteal perimeter2.24.58.8-1.82.73.0-2.62.3-1.81.8-2.62.61.8-1.21.91.61.2-2.1
Epididymis fat weight6.916.224.04.1-4.9-4.84.9-4.13.9-4.34.4-4.5-3.83.5-3.8-3.4-0.73.4
Delta time in closed arm before/after self-admin0.10.10.4-0.40.0-0.40.4-0.10.5-0.3-0.2-0.6-0.20.3-0.4-0.4-0.40.6
Delta time in open arm before/after self-admin0.20.21.0-1.00.80.8-0.50.5-0.5-0.1-0.30.30.4-0.30.20.10.10.1
Diff in mean of infusions in LGA sessions7.38.018.23.5-4.3-4.23.4-3.22.6-1.94.1-2.6-2.41.5-1.8-1.7-0.51.5
Delay discount exponential model param0.50.51.3-1.00.90.9-0.51.1-0.6-0.1-0.80.10.9-0.80.60.3-0.70.1
Extinction: sum of active levers before priming0.20.21.20.20.30.1-0.30.2-1.10.3-0.40.10.00.1-0.0-0.10.70.4
Active lever presses in extinction session 60.30.31.9-1.4-0.20.0-0.00.3-1.00.80.5-0.1-0.4-0.5-0.20.10.20.4
Bone: final force1.93.17.2-1.52.72.3-2.41.4-1.11.8-2.02.41.3-0.41.41.21.2-1.8
Bone: final moment1.93.18.3-1.62.92.4-2.41.4-0.91.7-2.22.41.2-0.21.21.11.3-1.7
Food consumed during 24 hour testing period0.70.93.1-1.81.01.4-0.71.3-0.70.8-0.80.21.0-0.90.70.7-0.80.1
Glucose0.40.75.6-0.50.80.7-0.5-0.5-0.30.4-0.50.80.20.7-0.5-0.52.4-0.5
Heart weight0.20.31.30.4-0.30.00.40.6-0.7-0.2-0.3-0.90.10.2-0.2-0.3-0.51.2
Delay discount hyperbolic model param0.60.71.7-0.90.70.7-0.51.3-0.70.1-0.80.11.2-1.20.90.7-1.1-0.1
Intermittent access intake day 1-15 change1.91.95.0-1.32.22.0-1.70.9-1.01.4-1.61.90.2-0.40.60.61.4-1.6
Intermittent access intake escalation1.51.54.4-1.22.11.8-1.50.4-0.71.1-1.51.6-0.0-0.00.20.21.7-1.3
Intermittent access intake escalation 20.70.72.6-1.11.61.5-0.90.4-0.10.2-1.10.9-0.20.20.0-0.01.1-0.8
Intermitt. access day 1 inactive lever presses0.70.71.9-1.31.41.2-0.81.1-0.90.7-0.80.50.7-1.00.50.4-0.1-0.3
Intermitt. access day 15 inactive lever presses0.70.71.6-0.91.31.2-1.10.6-0.81.0-1.01.10.3-0.50.50.40.7-0.8
Intermitt. access escalation Index0.10.10.4-0.20.2-0.00.20.10.2-0.2-0.7-0.20.3-0.3-0.00.0-0.00.0
Intermittent access day 1 total infusions0.30.30.60.7-0.2-0.6-0.30.3-0.70.60.00.30.7-0.70.70.8-0.5-0.2
Intermittent access day 15 total infusions1.21.43.1-0.21.60.9-1.60.6-1.11.6-1.21.80.7-0.71.11.20.5-1.7
Intermittent access terminal intake (last 3 days)0.60.71.7-0.91.30.7-1.00.8-0.80.9-1.00.90.7-0.60.70.80.0-0.8
Intermittent access total infusions0.30.30.8-0.10.6-0.1-0.70.4-0.70.9-0.50.70.6-0.50.70.8-0.2-0.7
Intermittent access day 1 locomotion0.30.31.00.8-0.4-0.7-0.00.4-1.00.10.4-0.30.6-0.20.30.4-0.90.4
Intermittent access day 15 total locomotion0.30.31.8-0.20.80.4-0.60.4-1.30.4-0.70.30.00.3-0.2-0.30.60.2
Intermittent access total locomotion0.20.21.7-0.20.2-0.1-0.20.8-1.30.2-0.3-0.20.5-0.10.10.1-0.40.6
Intermittent access standard deviation1.81.95.9-0.92.41.8-1.90.7-1.01.4-1.41.90.5-0.40.80.71.2-1.6
Left kidney weight0.82.16.7-2.31.82.0-1.22.2-2.61.4-1.4-0.11.1-0.20.00.10.61.0
Right kidney weight0.61.85.8-2.31.11.6-0.11.5-2.10.4-0.7-1.10.10.5-1.1-1.11.32.4
Cocaine induced anxiety2.02.35.00.8-1.2-1.31.7-1.42.2-1.90.8-1.7-1.51.9-1.7-1.5-0.21.5
Post-drug Anxiety0.10.20.30.5-0.3-0.30.4-0.30.5-0.3-0.3-0.5-0.30.5-0.4-0.3-0.40.4
Baseline Anxiety1.41.54.1-0.60.91.1-1.31.3-2.01.6-0.81.11.4-1.61.41.2-0.2-1.0
Tail length2.06.110.90.11.31.5-2.72.7-2.62.7-2.02.72.7-2.93.33.2-1.2-3.0
Length with tail0.52.07.3-0.70.50.7-1.02.4-2.71.8-1.10.21.8-1.61.31.4-0.90.1
Length without tail0.51.04.4-1.50.00.10.31.2-1.90.9-0.1-1.50.5-0.1-0.6-0.20.12.1
Times rat made contact with spout0.70.83.40.0-0.1-0.20.9-1.01.8-1.00.1-1.0-0.71.1-0.9-0.8-0.61.2
Lifetime Intake0.50.51.50.20.6-0.1-0.90.3-1.01.2-0.41.00.5-0.60.81.00.1-1.0
Liver weight, left0.40.72.50.7-0.10.60.3-0.80.2-0.60.1-0.5-0.61.6-1.3-1.21.30.9
Liver weight, right0.71.25.4-0.71.41.4-0.4-0.2-0.5-0.0-0.50.0-0.71.7-1.5-1.32.30.8
Locomotor activity0.91.56.8-2.61.61.5-1.21.3-1.11.2-1.00.71.3-0.80.70.60.10.3
Locomotor testing distance1.52.69.4-3.12.42.4-1.51.8-1.61.0-2.00.81.4-0.70.60.30.50.6
Locomotor testing rearing3.55.412.9-3.53.63.4-2.52.5-2.21.5-3.61.82.1-1.21.41.00.6-0.1
Locomotion in novel chamber0.20.32.21.5-0.8-0.80.2-0.5-0.20.2-0.0-0.0-0.10.1-0.20.1-0.1-0.2
Locomotion in novel chamber post-restriction0.91.06.7-0.4-1.0-0.61.00.10.0-0.60.1-1.8-0.10.3-0.7-0.6-1.32.6
Fecal boli incidents, locomotor time 11.41.55.01.7-0.2-0.2-0.31.10.1-0.40.30.41.4-1.71.81.4-2.2-1.7
Change in fecal boli incidents, locomotor task0.80.72.7-1.40.80.7-1.10.3-1.11.7-0.70.90.4-0.30.50.60.5-0.6
Time >=10cm from walls, locomotor time 10.40.41.4-1.00.70.5-0.40.60.50.20.10.10.8-0.60.60.6-1.2-0.4
Bouts of movement, locomotor time 14.65.012.82.4-3.6-2.82.8-1.42.1-2.23.2-2.9-0.80.8-1.0-0.9-2.41.6
Total resting periods, locomotor time 14.54.912.72.5-3.6-3.02.7-1.62.0-2.13.2-2.8-0.90.9-1.1-0.9-2.11.5
Rest time, locomotor task time 12.12.36.51.9-2.4-1.81.6-0.41.5-1.71.7-1.70.4-0.00.1-0.0-2.50.8
Distance moved, locomotor task time 11.81.96.1-2.32.51.9-1.10.5-0.90.7-1.80.9-0.60.4-0.7-0.62.30.4
Vertical activity count, locomotor time 11.21.34.7-1.01.40.7-0.1-0.70.5-0.4-0.30.2-1.61.6-1.5-1.52.20.3
Time >=10cm from walls, locomotor time 20.80.93.6-1.31.91.6-1.20.8-0.30.4-1.10.90.7-0.10.40.40.1-0.6
Bouts of movement, locomotor time 21.51.63.11.6-1.7-1.81.4-0.91.3-1.11.7-1.4-0.40.1-0.4-0.4-1.70.7
Total resting periods, locomotor time 22.62.86.11.9-2.5-2.42.0-1.31.7-1.62.4-1.9-0.60.3-0.7-0.7-1.91.1
Rest time, locomotor task time 21.51.88.20.9-1.9-1.71.30.30.9-1.21.3-1.60.9-0.80.60.4-2.90.7
Distance moved, locomotor task time 21.51.75.4-2.31.92.0-0.80.4-0.80.4-1.30.2-0.61.0-1.1-1.02.01.1
Vertical activity count, locomotor time 21.71.86.5-0.30.50.60.4-1.21.0-1.10.4-0.0-2.12.0-1.9-2.02.60.5
Light reinforcement 10.10.20.70.20.00.40.20.10.1-0.40.1-0.3-0.50.9-0.6-0.70.60.4
Light reinforcement 20.40.61.70.8-1.0-0.10.7-0.50.8-0.80.6-0.6-0.81.3-0.8-0.90.90.3
Bone: marrow area1.22.65.0-0.51.71.9-2.11.6-1.21.6-1.92.21.2-0.91.81.60.5-2.1
Bone: maximum diameter1.93.56.3-2.21.91.9-2.02.5-2.02.1-1.91.42.2-1.61.91.9-0.5-1.0
Bone: maximum force1.52.66.5-1.82.62.3-2.11.6-1.21.5-1.91.81.2-0.21.00.91.2-1.1
Bone: maximum moment1.62.87.8-1.82.82.5-2.21.6-1.11.4-2.11.91.2-0.00.90.81.3-1.0
Mean time between licks in bursts0.60.92.6-1.11.51.6-0.91.6-0.90.2-1.50.40.5-0.30.50.3-0.10.2
Mean num. licks in bursts1.01.23.70.4-0.0-0.70.8-1.31.3-0.80.2-0.7-1.31.9-1.5-1.41.21.1
Cd content in liver1.31.42.51.1-0.8-1.01.0-1.51.4-1.21.3-0.6-1.61.5-1.2-1.40.90.3
Co content in liver0.81.03.5-1.90.81.0-0.91.0-1.01.4-0.60.61.0-1.10.90.9-0.4-0.2
Cu content in liver0.80.93.0-0.30.80.9-1.1-0.0-0.61.0-0.51.60.6-0.70.80.71.3-1.7
Fe content in liver3.64.37.02.1-2.7-2.02.5-2.31.5-2.12.3-2.2-2.11.8-2.2-2.20.51.7
K content in liver0.50.51.2-0.30.71.0-0.90.8-1.10.6-0.90.90.6-0.20.50.30.7-0.8
Mg content in liver0.50.51.0-0.50.60.9-0.91.0-1.00.6-0.60.70.7-0.60.70.60.1-0.9
Mn content in liver1.21.43.2-1.81.61.8-1.31.3-1.31.0-1.01.11.0-1.00.80.70.7-0.7
Na content in liver1.01.15.3-0.90.81.3-1.11.1-2.31.5-0.80.60.8-0.20.20.31.1-0.2
Rb content in liver1.72.23.3-1.21.31.4-1.61.5-1.21.8-1.51.51.6-1.71.51.7-0.6-1.5
Se content in liver0.30.32.00.4-0.3-0.60.5-0.30.8-0.60.3-0.6-0.2-0.2-0.0-0.0-1.40.4
Sr content in liver1.11.02.8-1.71.61.3-1.01.1-0.61.0-1.40.60.7-0.60.70.6-0.3-0.4
Zn content in liver0.50.63.90.5-0.3-0.2-0.10.9-0.40.4-0.3-0.40.9-0.70.81.0-2.00.2
Bone: minimum diameter0.50.91.8-1.11.21.3-1.11.3-1.20.8-1.00.80.7-0.20.50.40.7-0.3
Time in familiar zone, hab. session 12.22.04.8-0.20.91.3-1.61.2-0.91.5-1.01.91.4-1.52.01.9-0.2-2.2
Time in novel zone, hab. session 13.43.47.00.4-1.0-1.11.9-1.91.3-1.91.2-2.0-2.12.2-2.6-2.71.22.3
Total zone transitions, hab. session 10.60.84.2-2.11.00.9-0.41.2-0.40.7-0.6-0.41.10.20.10.2-0.41.2
Total locomotion distance, hab. session 10.81.26.9-2.61.61.7-0.81.2-0.60.6-0.70.40.90.20.1-0.11.00.4
Locomotion velocity, hab. session 10.50.74.2-2.01.11.1-0.71.0-0.50.5-0.30.30.80.30.1-0.00.70.4
Time in familiar zone, hab. session 23.43.57.31.7-2.4-2.12.4-1.01.6-1.91.6-2.7-1.32.0-1.8-1.5-0.62.4
Time in novel zone, hab. session 22.42.44.9-1.11.81.4-1.91.0-1.41.6-1.32.21.2-1.91.71.40.1-2.1
Total zone transitions, hab. session 20.30.43.1-1.80.3-0.0-0.00.7-0.40.70.1-0.51.0-0.10.00.2-0.30.9
Total locomotion distance, hab. session 20.40.51.8-1.3-0.3-0.50.7-0.20.5-0.20.7-0.7-0.10.6-0.8-0.70.71.0
Locomotion velocity, hab. session 20.40.61.5-1.2-0.3-0.40.7-0.40.6-0.30.7-0.7-0.30.9-1.0-1.01.11.0
Novel to familiar place preference ratio0.40.42.3-0.6-0.3-0.20.10.6-0.50.90.1-0.60.6-0.60.40.6-1.50.7
Novelty place preference0.30.31.8-0.3-0.6-0.50.30.2-0.30.60.3-0.70.3-0.30.10.3-1.30.8
Time in novel zone, NPP test0.30.32.2-0.2-0.6-0.50.30.3-0.30.50.3-0.70.3-0.30.10.4-1.50.8
Total zone transitions, NPP test0.30.41.6-0.9-0.3-0.60.30.70.00.40.5-0.70.9-0.40.40.5-1.30.8
Total locomotion distance, NPP test0.30.43.6-1.90.40.4-0.20.9-0.20.60.2-0.00.7-0.30.30.20.00.3
Locomotion velocity, NPP test0.40.64.6-2.20.70.7-0.50.9-0.40.8-0.10.30.8-0.30.30.20.40.1
Intraocular pressure0.20.21.1-0.50.80.4-0.30.40.00.0-1.1-0.20.4-0.10.30.3-0.80.5
Delta distance traveled before/after self-admin0.50.52.9-0.10.60.5-0.3-0.80.3-0.4-0.60.9-0.80.6-0.5-0.61.7-0.5
Delta ambulatory time before/after self-admin0.80.92.7-0.31.51.4-1.0-0.1-0.40.3-1.61.4-0.20.1-0.0-0.11.6-0.8
Parametrial fat weight4.38.414.53.4-2.2-2.73.0-3.23.5-3.52.1-2.5-3.03.8-3.1-3.11.02.1
Pavlov. Cond. lever latency0.81.04.12.0-0.7-0.60.5-1.00.3-1.10.6-0.0-1.21.3-0.7-1.11.3-0.3
Pavlov. Cond. magazine entry latency0.50.61.3-0.50.10.2-0.70.5-0.81.20.00.71.0-1.11.01.1-0.3-0.9
Pavlov. Cond. change in total contacts0.70.72.1-1.40.70.4-0.80.5-0.81.30.01.00.6-1.30.80.90.1-1.0
Pavlov. Cond. index score1.01.33.0-1.70.80.9-1.01.2-1.21.4-0.40.81.5-1.71.21.4-0.5-0.6
Pavlov. Cond. latency score1.31.64.2-2.00.90.9-1.01.3-1.01.6-0.60.71.6-1.91.31.6-1.0-0.4
Pavlov. Cond. lever contacts0.70.83.4-1.80.20.4-0.21.0-0.71.1-0.0-0.21.1-1.40.61.0-1.10.4
Pavlov. Cond. magazine entry number0.50.61.80.8-0.4-0.40.7-0.00.5-0.8-0.2-1.2-0.41.0-0.6-0.7-0.91.3
Pavlov. Cond. intertrial magazine entries1.41.73.5-1.21.51.7-1.51.9-1.21.0-1.11.21.4-1.21.51.2-0.6-0.9
Pavlov. Cond. lever-magazine prob. diff.0.91.22.6-1.50.60.8-0.91.1-1.31.5-0.30.71.4-1.61.01.3-0.5-0.5
Pavlov. Cond. response bias0.50.61.8-0.90.20.4-0.60.3-0.81.00.30.90.7-1.30.80.90.2-0.9
Pavlov. Cond. lever latency2.12.84.92.2-2.0-1.71.8-2.01.7-1.71.9-1.1-1.91.7-1.5-1.71.00.6
Pavlov. Cond. magazine entry latency1.01.13.30.1-0.4-0.7-0.50.9-0.91.6-0.00.21.4-1.41.31.7-1.8-0.4
Pavlov. Cond. change in total contacts1.11.52.6-1.10.90.8-1.41.2-1.51.4-0.91.21.4-1.61.31.5-0.4-1.1
Pavlov. Cond. index score1.11.42.7-1.00.50.2-0.91.4-1.21.5-0.80.41.5-1.51.31.6-1.6-0.3
Pavlov. Cond. latency score0.91.12.5-0.70.20.0-0.71.2-1.11.4-0.60.21.4-1.41.21.5-1.6-0.3
Pavlov. Cond. lever contacts1.82.55.6-2.41.61.4-1.42.1-1.51.5-1.70.51.9-1.81.41.6-1.6-0.0
Pavlov. Cond. magazine entry number0.50.61.5-0.61.01.00.0-0.30.7-1.1-0.60.1-0.80.9-0.8-1.21.20.3
Pavlov. Cond. intertrial magazine entries0.81.03.6-1.81.61.9-0.80.4-0.40.1-0.90.8-0.30.4-0.3-0.61.8-0.2
Pavlov. Cond. lever-magazine prob. diff.0.81.02.2-0.80.40.2-0.91.2-1.11.4-0.60.41.3-1.31.11.5-1.3-0.4
Pavlov. Cond. response bias1.52.03.4-1.61.20.9-1.31.8-1.51.6-1.50.51.8-1.61.41.7-1.6-0.1
Time in closed arm before self-admin0.10.10.30.5-0.20.1-0.20.0-0.1-0.00.20.40.2-0.10.30.30.2-0.4
Time in closed arm after self-admin0.10.10.3-0.10.30.6-0.50.4-0.60.4-0.40.40.3-0.00.20.20.4-0.3
Time in open arm before self-admin1.01.13.01.6-1.7-1.71.1-1.21.2-0.21.4-0.7-0.80.3-0.4-0.1-0.6-0.4
Time in open arm after self-admin0.20.21.80.0-0.1-0.50.10.10.2-0.00.1-0.10.3-0.80.50.6-1.3-0.3
Bone: periosteal estimation1.73.65.6-1.72.32.2-2.42.3-1.82.0-2.22.01.9-1.21.81.70.2-1.5
Bone: periosteal perimeter2.74.47.5-2.42.62.7-2.42.6-2.42.1-2.42.02.1-1.41.71.50.8-1.3
Bone: post-yield work0.91.22.2-1.11.31.5-1.31.4-1.30.7-1.30.91.1-0.91.00.80.2-0.5
Progressive ratio test 1 active lever presses1.01.02.2-1.10.90.4-0.91.3-1.41.2-0.60.51.2-1.50.91.2-1.0-0.3
Progressive ratio test 1 breakpoint1.31.42.8-1.31.10.6-1.11.6-1.71.3-0.80.51.4-1.51.11.3-1.1-0.2
Progressive ratio test 1 inactive lever presses0.70.72.7-1.61.10.7-0.71.3-1.30.7-0.5-0.00.8-0.60.30.4-0.60.4
Progressive ratio test 2 active lever presses0.70.71.30.50.50.1-0.81.0-1.01.0-0.40.70.8-1.01.11.1-1.1-1.0
Progressive ratio test 2 breakpoint0.91.01.8-0.00.70.5-1.01.4-1.21.1-0.60.81.1-1.31.31.3-1.2-0.8
Progressive ratio test 2 inactive lever presses1.21.43.10.11.00.6-1.41.0-1.11.3-0.51.61.1-1.31.51.7-0.3-1.8
Incentive Sensitization - Responses1.51.52.8-0.00.80.7-1.11.6-0.91.2-1.10.91.5-1.41.71.6-1.7-1.1
Incentive Sensitization - Breakpoint1.51.63.20.00.90.8-1.11.7-0.81.1-1.20.91.5-1.41.71.6-1.8-1.1
Sum of active levers in priming session hrs 5-60.40.41.00.8-0.6-0.70.4-1.00.3-0.20.90.0-1.00.3-0.6-0.40.7-0.3
Progressive ratio0.30.40.90.3-0.4-0.1-0.30.6-0.90.70.40.00.9-0.90.60.8-0.9-0.2
Food seeking constrained by brief footshock0.50.63.21.8-1.1-0.90.4-1.20.4-0.10.60.1-0.50.6-0.4-0.20.9-0.5
Seeking ratio, punishment vs. effort0.40.52.20.20.0-0.10.3-1.00.6-0.50.10.2-1.01.0-0.8-0.81.5-0.2
Retroperitoneal fat weight5.116.829.92.9-3.5-3.14.6-3.73.5-4.32.9-5.0-4.15.5-5.1-4.91.14.9
Reaction time number correct0.70.92.4-1.51.41.4-0.2-0.00.2-0.5-0.50.0-0.91.1-1.1-1.11.50.6
Reaction time mean minus median0.91.14.82.2-1.6-1.90.9-1.10.8-0.71.2-0.4-0.60.7-0.1-0.3-0.40.1
Reaction time mean minus median AUC2.12.76.42.3-2.0-2.51.7-2.01.9-1.61.7-1.1-1.51.6-1.1-1.3-0.10.8
Reaction time num false alarms3.14.211.8-1.53.43.4-2.71.8-1.21.2-2.92.51.6-0.51.41.21.0-1.7
Reaction time num false alarms AUC3.75.114.5-1.53.73.8-3.01.7-1.21.5-2.92.91.7-0.71.61.41.1-2.1
Reaction time trials correct on left0.70.92.4-1.51.41.4-0.2-0.00.2-0.5-0.50.0-0.91.1-1.1-1.11.50.6
Reaction time trials on left0.60.92.3-1.51.51.4-0.30.00.2-0.5-0.50.0-0.91.1-1.0-1.11.50.6
Reaction time mean2.02.813.33.7-2.6-2.91.5-1.71.4-1.21.5-0.7-1.10.8-0.3-0.5-0.1-0.4
Reaction time mean AUC2.43.313.53.7-2.8-3.01.8-1.81.6-1.51.9-1.0-1.10.9-0.5-0.7-0.4-0.2
Median of all reaction times2.02.812.43.5-2.7-2.81.6-1.81.4-1.21.5-0.7-1.20.8-0.5-0.60.1-0.5
Reaction time omissions0.30.51.81.3-0.8-1.10.6-0.50.7-0.80.7-0.3-0.40.7-0.1-0.30.1-0.0
Reaction time false alarm rate2.63.66.5-0.62.52.6-2.41.7-1.21.6-2.42.42.1-1.32.01.80.0-2.0
Reaction time premature initiation rate0.10.21.20.5-0.5-0.40.10.1-0.20.30.1-0.20.0-0.10.30.4-1.10.3
Reaction time premature initiations0.10.10.3-0.40.50.5-0.20.1-0.00.0-0.3-0.1-0.50.5-0.2-0.2-0.20.6
Std. dev. reaction times0.91.27.22.7-1.5-2.00.7-1.10.9-0.81.0-0.0-0.40.60.1-0.1-0.2-0.5
Reaction time trials completed0.60.92.3-1.51.51.4-0.30.00.2-0.5-0.50.0-0.91.1-1.0-1.11.50.6
Reaction time trials AUC0.71.12.9-1.71.61.5-0.40.10.1-0.3-0.60.2-0.91.1-1.0-1.01.70.6
Run reversals in cocaine runway, females0.50.51.3-0.6-0.2-0.10.5-0.40.3-0.90.9-0.8-0.71.1-0.9-1.00.31.1
Run reversals in cocaine runway, males2.72.74.80.8-1.3-1.11.7-2.01.6-1.31.6-1.3-2.02.2-2.1-2.01.51.5
Latency to leave start box in cocaine runway0.30.31.0-0.4-0.6-0.30.7-0.11.0-0.50.6-0.7-0.10.2-0.2-0.1-0.60.6
Latency to leave start box in cocaine runway, F0.30.41.3-1.0-0.20.20.10.90.00.3-0.0-0.40.9-0.80.60.5-1.10.4
Latency to leave start box in cocaine runway, M1.51.52.21.0-1.4-1.21.4-1.31.5-1.31.4-1.1-1.31.2-1.2-1.00.10.9
Std. dev. time between licks in bursts1.41.72.9-1.31.61.1-1.51.6-1.21.1-1.71.11.2-1.51.41.3-0.8-0.8
Total sessions with >9 infusions1.41.54.20.90.60.1-1.40.7-1.72.0-0.41.41.0-1.31.31.7-0.8-1.4
Short access day 1 total inactive lever presses0.30.31.7-0.60.60.3-0.5-0.1-0.81.00.40.6-0.20.2-0.20.01.3-0.3
Short access day 10 total inactive lever presses0.70.82.0-0.61.41.4-1.10.7-1.20.8-1.11.00.3-0.50.40.41.0-0.7
Short access day 1 total infusions0.20.31.10.9-0.1-0.6-0.4-0.3-0.81.00.20.4-0.10.1-0.00.40.2-0.3
Short access day 10 total infusions1.11.23.2-1.21.00.7-1.11.3-1.81.4-0.90.71.2-1.30.91.1-0.5-0.3
Short access total infusions0.40.41.20.50.3-0.4-0.7-0.0-1.01.10.10.80.3-0.60.50.90.3-0.9
Short access day 1 locomotion0.20.31.30.50.40.0-0.60.5-1.10.9-0.30.20.5-0.20.30.5-0.20.0
Short access day 10 total locomotion0.30.31.81.0-0.4-0.7-0.00.5-0.3-0.10.2-0.30.6-0.20.40.4-1.30.2
Short access total locomotion0.40.41.31.10.0-0.4-0.60.6-1.10.70.00.20.7-0.30.60.8-1.1-0.2
One hour access (0.3 mA shock)1.01.22.1-0.41.40.7-1.21.1-0.71.0-1.41.01.3-0.81.41.3-1.0-1.0
Compulsive drug intake0.30.41.00.80.3-0.1-0.0-1.00.6-0.20.40.3-0.80.8-0.7-0.51.0-0.2
One hour access (shock baseline)0.30.31.1-0.70.2-0.1-0.11.0-0.40.2-0.5-0.30.9-0.40.60.5-1.10.1
Social response proportion0.50.51.41.1-1.2-1.10.4-0.90.8-0.11.20.1-0.30.20.10.2-0.2-0.6
Social responses3.34.38.3-1.41.81.7-2.51.8-2.52.9-1.62.62.1-1.92.12.20.5-2.3
Social time1.11.54.3-0.11.20.6-1.70.5-0.71.3-0.51.91.1-1.11.51.6-0.3-2.1
Soleus weight0.20.52.1-0.51.01.2-0.70.0-0.60.3-0.70.6-0.10.7-0.4-0.41.50.0
Bone: stiffness3.35.19.1-1.82.92.6-3.02.0-2.22.7-2.42.91.9-1.21.91.91.3-2.3
Tibialis anterior weight0.00.10.70.2-0.2-0.20.1-0.40.40.40.00.10.2-0.50.30.5-0.8-0.3
Time to tail flick, vehicle, before self-admin0.70.72.31.5-0.3-0.2-0.50.5-0.10.4-0.40.60.7-0.71.11.2-1.5-1.1
Time to tail flick, vehicle, after self-admin2.72.95.72.3-1.7-1.81.7-2.02.0-2.41.7-1.1-1.71.5-1.5-1.50.50.8
Time to tail flick, test, before self-admin1.51.53.00.7-1.0-0.91.3-1.31.3-1.40.3-1.1-1.21.7-1.4-1.50.71.7
Time to tail flick, test, after self-admin0.10.21.00.5-0.10.2-0.0-0.6-0.2-0.00.30.2-0.30.4-0.4-0.41.0-0.1
Delta time to tail flick, vehicle, before/after SA1.61.63.10.1-0.8-0.71.4-1.41.4-1.81.2-1.0-1.41.2-1.5-1.71.31.2
Delta time to tail flick, test, before/after SA0.30.31.30.4-0.10.1-0.40.1-0.20.50.50.50.4-0.60.60.7-0.3-1.2
Tibia length3.28.920.9-3.92.43.0-2.74.6-3.73.6-2.81.23.7-2.92.72.7-1.4-0.6
Ambulatory time before self-admin3.13.28.1-1.41.21.3-1.82.4-2.82.3-1.21.22.2-2.02.02.0-0.7-0.8
Ambulatory time after self-admin2.72.95.6-0.91.81.7-2.21.5-2.41.9-2.12.21.3-1.31.61.50.9-1.6
Bone: tissue strength0.40.41.5-0.71.01.2-0.50.1-0.4-0.0-0.40.30.10.4-0.4-0.41.00.2
Total heroin consumption0.40.52.11.0-1.0-0.90.4-0.90.0-0.11.4-0.1-0.70.0-0.5-0.20.3-0.3
Bone: trabecular number0.81.22.90.3-1.7-1.51.5-0.61.1-0.81.6-1.6-0.6-0.0-0.6-0.4-1.21.0
Bone: trabecular spacing0.50.72.1-0.41.41.2-1.10.4-0.91.0-1.40.80.60.30.20.40.5-0.2
Bone: trabecular thickness0.10.10.3-0.0-0.4-0.40.4-0.00.4-0.60.6-0.3-0.2-0.0-0.1-0.3-0.10.0
Bone: trabecular tissue density0.30.41.6-0.70.60.1-0.70.5-1.30.6-0.50.50.5-0.20.20.11.1-0.3
Water consumed over 24 hours1.62.04.7-2.21.21.4-1.11.9-1.41.4-1.00.41.9-1.71.31.3-1.2-0.1
Number of responses in last shaping day0.30.30.80.9-0.9-0.6-0.0-0.3-0.20.50.30.3-0.0-0.50.40.6-0.5-0.6