Hub : Genes

Coa8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Coa8 0.05 0.05 7.0e-05 0.03 0.03 0.03 0.03 1.0e-04 1.7e-04 3.8e-04 2.6e-04
2 NAcc gene expression Coa8 0.08 0.06 5.5e-12 0.07 0.08 0.07 0.07 2.5e-10 8.0e-12 7.0e-11 2.2e-10
3 Liver gene expression Coa8 0.25 0.2 7.2e-10 0.06 0.07 0.07 0.07 9.7e-08 1.9e-08 6.0e-08 4.1e-08
4 Brain gene expression Coa8 0.16 0.12 3.4e-13 0.13 0.14 0.15 0.15 3.1e-12 6.5e-13 6.6e-14 1.7e-13
5 PL isoform ratio NM_001037769.2 0.03 0.03 4.2e-04 0.02 0.03 0.02 0.02 1.1e-03 8.7e-04 2.5e-03 1.3e-03
6 NAcc isoform ratio XM_063261788.1 0.03 0.02 8.7e-05 0.02 0.03 0.02 0.02 2.6e-04 9.3e-05 2.4e-04 2.5e-04
7 NAcc isoform ratio NM_001037769.2 0.01 0.01 8.1e-03 0.01 0.01 0.01 0.01 2.4e-02 9.9e-03 2.0e-02 2.6e-02
8 Liver isoform ratio XM_063261788.1 0.03 0.03 3.3e-03 0.01 0.01 0.01 0.01 2.0e-02 1.7e-02 1.8e-02 2.3e-02
9 IC gene expression Coa8 0.15 0.13 3.1e-04 0.03 0.07 0.03 0.05 1.7e-02 1.0e-03 2.2e-02 2.7e-03
10 BLA gene expression Coa8 0.13 0.1 1.4e-06 0.09 0.11 0.12 0.11 2.1e-05 1.3e-06 3.8e-07 1.3e-06
11 Liver isoform ratio NM_001037769.2 0.03 0.03 4.3e-03 0.02 0.01 0.01 0.01 4.8e-03 1.4e-02 1.4e-02 8.8e-03
12 pVTA gene expression Coa8 0.09 0.08 1.9e-06 0.08 0.07 0.08 0.07 5.3e-07 1.8e-06 7.6e-07 1.3e-06
13 PL gene expression Coa8 0.04 0.04 1.6e-04 0.03 0.02 0.02 0.03 2.1e-04 1.4e-03 2.2e-03 8.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.20.40.60.50.50.50.4-0.40.4-0.40.40.40.50.50.5
Area under the delay curve0.10.20.40.30.30.20.50.3-0.30.3-0.40.30.30.50.50.7
BMI with tail3.913.314.63.53.83.83.23.8-3.83.8-3.83.83.63.33.33.8
BMI without tail2.78.310.02.63.13.22.43.0-3.13.0-3.03.02.92.42.43.1
Body weight0.10.21.1-0.8-0.3-0.3-1.0-0.30.3-0.30.3-0.3-0.4-0.4-0.4-0.3
Weight adjusted by age0.00.00.1-0.1-0.2-0.2-0.3-0.20.2-0.20.1-0.1-0.2-0.1-0.1-0.2
Bone surface0.10.20.30.50.50.60.30.4-0.40.4-0.40.40.10.50.50.5
Bone volume0.10.20.40.40.60.60.40.5-0.50.5-0.40.40.30.60.60.6
Breakpoint value in progressive ratio session0.00.10.40.1-0.1-0.10.2-0.20.2-0.20.2-0.2-0.3-0.1-0.1-0.6
Number of licking bursts0.10.10.5-0.1-0.2-0.2-0.4-0.20.2-0.20.3-0.3-0.3-0.7-0.7-0.6
Context. condit. distance diff. score1.61.93.5-1.9-1.5-1.4-1.4-1.41.4-1.41.4-1.4-1.4-1.3-1.30.2
Locomotion velocity, session 10.20.20.5-0.4-0.4-0.3-0.6-0.50.5-0.50.5-0.5-0.7-0.5-0.5-0.1
Locomotion distance, session 10.50.61.21.00.80.80.90.7-0.70.7-0.60.60.40.70.71.1
Locomotion velocity, session 20.10.10.9-0.2-0.0-0.10.20.1-0.10.1-0.10.10.20.50.50.9
Locomotion distance, session 20.40.50.60.70.70.70.70.7-0.70.7-0.60.70.60.80.80.8
Locomotion velocity, session 30.40.53.30.40.40.40.70.4-0.40.5-0.50.50.50.80.81.8
Locomotion distance, session 30.10.22.00.1-0.1-0.0-0.0-0.10.1-0.10.1-0.1-0.1-0.1-0.11.4
Stereotopy head waving bouts, day 30.10.10.2-0.4-0.4-0.4-0.4-0.40.4-0.40.4-0.4-0.4-0.3-0.3-0.1
Stereotopy head waving duration, day 30.30.40.9-0.7-0.6-0.6-0.5-0.60.6-0.60.6-0.6-0.6-0.4-0.4-0.9
Locomotion velocity, session 70.40.51.70.70.40.30.90.5-0.50.5-0.50.50.60.70.71.3
Locomotion distance, session 70.91.13.81.00.90.91.20.9-0.90.9-0.90.90.91.01.02.0
Stereotopy head waving bouts, day 70.60.71.1-0.8-0.9-0.9-0.9-0.80.8-0.80.8-0.8-0.8-0.7-0.7-1.1
Stereotopy head waving duration, day 70.30.41.1-0.6-0.6-0.7-0.6-0.60.6-0.60.6-0.6-0.6-0.4-0.4-1.0
Locomotion velocity, session 80.20.20.6-0.8-0.5-0.5-0.3-0.50.5-0.40.4-0.4-0.4-0.2-0.20.5
Locomotion distance, session 80.20.22.2-0.20.20.30.30.2-0.20.2-0.20.20.20.30.31.5
Degree of sensitization distance0.10.10.20.40.20.20.40.3-0.30.3-0.30.30.30.30.3-0.2
Degree of sensitization stereotypy0.20.20.5-0.3-0.4-0.4-0.5-0.50.5-0.50.5-0.5-0.5-0.4-0.4-0.7
Conditioned locomotion1.11.31.7-1.3-1.2-1.2-1.0-1.21.2-1.11.1-1.1-1.1-0.8-0.8-1.2
Cocaine response after cond. corrected0.50.60.80.70.80.80.70.7-0.70.7-0.70.70.70.70.70.9
Cocaine response after cond. not corrected1.82.12.41.41.51.51.41.5-1.51.5-1.51.51.51.41.41.5
Cocaine response before conditioning2.52.93.71.71.71.71.71.7-1.71.7-1.71.71.81.51.51.9
Saline control response0.20.20.90.30.40.50.50.4-0.40.4-0.40.40.30.30.31.0
Bone: connectivity density0.00.00.0-0.0-0.1-0.1-0.1-0.10.1-0.10.1-0.1-0.10.10.1-0.1
Bone: cortical apparent density8.211.312.4-3.2-3.5-3.5-3.2-3.43.4-3.43.4-3.4-3.2-3.2-3.2-3.5
Bone: cortical area0.60.91.4-1.0-0.7-0.6-1.0-0.90.9-0.91.0-1.0-1.1-1.2-1.2-0.8
Bone: cortical porosity0.00.00.2-0.4-0.2-0.1-0.1-0.10.1-0.10.1-0.1-0.1-0.1-0.1-0.1
Bone: cortical porosity0.20.20.30.30.50.50.60.4-0.40.4-0.40.40.40.40.40.5
Bone: cortical thickness0.61.11.4-0.9-0.9-0.8-0.8-1.01.0-1.11.1-1.1-1.2-1.1-1.1-1.0
Bone: cortical thickness0.81.01.1-1.0-0.9-0.8-0.9-1.01.0-1.01.0-1.0-1.0-1.0-1.0-1.0
Bone: cortical tissue density8.111.012.2-3.2-3.5-3.5-3.2-3.43.4-3.43.3-3.3-3.2-3.1-3.1-3.5
Condit. Reinf. active minus inactive responses0.60.71.50.70.80.80.70.8-0.80.8-0.80.80.80.70.71.2
Condit. Reinf. active-inactive response ratio2.62.83.31.71.71.71.71.7-1.71.7-1.71.71.61.61.61.8
Condit. Reinf. active responses0.20.30.80.30.40.40.40.5-0.50.5-0.50.50.60.60.60.9
Condit. Reinf. inactive responses1.72.12.3-1.5-1.5-1.5-1.5-1.51.5-1.51.5-1.5-1.5-1.4-1.4-0.9
Incentive salience index mean0.50.71.50.80.80.80.70.8-0.80.8-0.80.80.70.70.71.2
Condit. Reinf. lever presses0.20.20.40.60.40.40.50.4-0.40.4-0.50.40.40.60.60.5
Condit. Reinf. active minus inactive responses0.20.30.8-0.9-0.6-0.6-0.5-0.60.6-0.60.6-0.5-0.6-0.4-0.40.2
Condit. Reinf. active-inactive response ratio0.40.41.0-1.0-0.6-0.6-0.6-0.60.6-0.60.6-0.6-0.6-0.5-0.5-0.6
Condit. Reinf. active responses0.10.11.0-0.20.10.10.20.2-0.20.2-0.20.20.20.30.31.0
Condit. Reinf. inactive responses0.91.13.00.81.01.00.91.0-1.01.0-1.01.01.10.90.91.7
Condit. Reinf. lever presses1.82.53.31.11.61.61.51.6-1.61.6-1.61.61.61.61.61.8
Condit. Reinf. lever reinforcers received0.10.10.5-0.30.10.10.20.2-0.20.2-0.20.20.30.30.30.7
Conditioned reinforcement - actives0.50.81.4-1.2-0.9-1.0-0.9-0.90.9-0.90.9-0.9-0.8-0.8-0.8-0.8
Conditioned reinforcement - inactives0.10.20.5-0.7-0.5-0.5-0.4-0.40.4-0.40.4-0.4-0.3-0.2-0.2-0.2
Conditioned locomotion0.50.71.40.40.70.70.90.7-0.80.8-0.80.80.81.21.20.6
Patch foraging indifference point 0 sec2.85.26.7-2.6-2.5-2.5-2.4-2.32.3-2.32.3-2.3-2.1-2.1-2.1-1.9
Patch foraging indifference point AUC1.72.43.0-1.6-1.7-1.7-1.5-1.61.7-1.61.6-1.6-1.7-1.3-1.3-0.8
Delay disc. indifference point, 0s delay0.20.20.3-0.4-0.5-0.6-0.2-0.50.5-0.50.4-0.4-0.4-0.2-0.2-0.2
Delay disc. indifference point, 16s delay0.10.10.2-0.20.20.20.30.3-0.20.2-0.30.30.10.30.30.4
Delay disc. indifference point, 2s delay0.10.10.60.80.20.20.50.2-0.20.2-0.20.20.20.30.30.4
Delay disc. indifference point, 24s delay0.20.21.20.90.40.40.30.4-0.40.3-0.30.30.30.00.01.1
Delay disc. indifference point, 4s delay0.10.10.3-0.4-0.5-0.6-0.2-0.40.4-0.40.4-0.4-0.4-0.1-0.1-0.3
Delay disc. indifference point, 8s delay0.30.30.50.50.40.30.70.5-0.50.5-0.60.60.60.60.60.6
Indifference point function ln k0.40.71.3-0.7-0.8-0.7-1.0-0.80.8-0.80.8-0.7-0.7-0.8-0.8-1.2
Indifference point function log k0.40.71.3-0.7-0.8-0.7-1.0-0.80.8-0.80.8-0.7-0.7-0.8-0.8-1.2
Patch foraging total patch changes 0 sec3.05.77.5-2.7-2.6-2.7-2.4-2.42.4-2.42.4-2.4-2.1-2.2-2.2-2.0
Patch foraging total patch changes 12 sec3.64.76.2-2.3-2.4-2.5-2.1-2.22.2-2.22.2-2.2-2.0-2.0-2.0-1.9
Patch foraging total patch changes 18 sec1.01.62.9-1.4-1.5-1.7-0.9-1.41.4-1.41.3-1.3-1.3-0.8-0.8-0.6
Patch foraging total patch changes 24 sec0.10.20.4-0.6-0.6-0.6-0.4-0.50.5-0.40.4-0.4-0.3-0.3-0.3-0.3
Patch foraging total patch changes 6 sec2.03.15.5-2.3-1.9-2.0-1.9-1.71.7-1.71.7-1.7-1.4-1.7-1.7-1.1
Patch foraging time to switch 0 sec7.615.517.44.24.14.14.14.1-4.14.1-4.14.14.03.63.62.8
Patch foraging water rate 0 sec13.528.431.8-5.6-5.6-5.6-5.5-5.55.5-5.55.5-5.5-5.3-5.0-5.0-3.9
Patch foraging water rate 12 sec7.215.118.2-4.2-3.9-3.8-4.3-3.93.9-3.93.9-3.8-3.7-4.1-4.1-2.8
Patch foraging water rate 18 sec4.56.98.4-2.4-2.7-2.6-2.9-2.72.7-2.72.7-2.7-2.5-2.8-2.8-2.0
Patch foraging water rate 24 sec4.05.66.7-2.3-2.3-2.3-2.5-2.42.4-2.42.4-2.4-2.4-2.6-2.6-1.6
Patch foraging water rate 6 sec4.46.48.6-2.9-2.7-2.7-2.5-2.62.6-2.62.6-2.6-2.4-2.2-2.2-2.1
Seeking ratio, delayed vs. immediate footshock0.10.20.4-0.1-0.4-0.4-0.5-0.40.4-0.50.5-0.5-0.6-0.4-0.4-0.1
Distance traveled before self-admin0.40.50.80.60.60.50.50.7-0.70.7-0.70.70.70.90.90.6
Distance traveled after self-admin0.10.10.3-0.5-0.3-0.3-0.4-0.30.3-0.30.3-0.3-0.3-0.4-0.4-0.3
Extensor digitorum longus weight5.622.025.6-5.1-4.7-4.5-5.0-4.74.7-4.74.7-4.7-4.7-4.5-4.5-4.5
Bone: elastic displacement0.50.60.7-0.5-0.7-0.7-0.6-0.80.8-0.80.8-0.8-0.8-0.8-0.8-0.8
Bone: elastic work0.20.30.5-0.3-0.4-0.3-0.4-0.50.5-0.50.6-0.6-0.7-0.7-0.7-0.4
Bone: endosteal estimation0.30.71.10.41.01.10.50.9-0.90.9-0.90.90.60.70.71.1
Bone: endosteal perimeter0.00.10.3-0.30.40.5-0.20.3-0.30.3-0.20.30.1-0.1-0.10.6
Epididymis fat weight2.79.310.03.23.13.02.93.1-3.13.1-3.13.13.12.72.73.1
Delta time in closed arm before/after self-admin0.00.00.1-0.10.20.20.10.2-0.20.2-0.20.20.2-0.0-0.00.1
Delta time in open arm before/after self-admin0.70.71.6-0.6-0.8-0.9-0.9-0.80.8-0.80.8-0.8-0.9-0.6-0.6-1.3
Diff in mean of infusions in LGA sessions0.00.10.30.0-0.1-0.10.4-0.00.0-0.00.0-0.00.10.50.5-0.3
Delay discount exponential model param0.20.20.5-0.4-0.3-0.2-0.5-0.30.3-0.30.4-0.4-0.3-0.5-0.5-0.7
Extinction: sum of active levers before priming0.30.30.70.70.60.60.80.6-0.60.6-0.60.60.50.50.50.3
Active lever presses in extinction session 61.41.41.9-1.1-1.2-1.2-1.1-1.21.2-1.21.2-1.2-1.2-0.9-0.9-1.4
Bone: final force0.20.30.5-0.6-0.3-0.2-0.5-0.40.4-0.50.5-0.5-0.6-0.7-0.7-0.3
Bone: final moment0.20.30.6-0.5-0.3-0.2-0.6-0.50.5-0.50.5-0.5-0.7-0.8-0.8-0.3
Food consumed during 24 hour testing period0.10.10.3-0.5-0.3-0.2-0.4-0.30.3-0.30.3-0.3-0.4-0.2-0.2-0.2
Glucose0.71.11.5-0.8-1.1-1.2-1.0-1.11.1-1.11.1-1.1-1.1-1.0-1.0-1.1
Heart weight0.60.91.3-1.2-1.0-1.1-0.9-1.01.0-1.01.0-1.0-0.9-0.6-0.6-1.0
Delay discount hyperbolic model param0.10.10.4-0.4-0.2-0.1-0.5-0.20.2-0.30.3-0.3-0.2-0.4-0.4-0.6
Intermittent access intake day 1-15 change1.63.44.91.61.81.82.11.8-1.81.8-1.71.71.71.91.92.2
Intermittent access intake escalation1.63.24.91.51.71.72.01.7-1.71.7-1.71.71.71.91.92.2
Intermittent access intake escalation 20.80.91.50.90.91.01.10.9-0.90.9-0.90.90.81.01.01.2
Intermitt. access day 1 inactive lever presses0.10.60.7-0.8-0.8-0.8-0.8-0.80.8-0.80.8-0.8-0.8-0.7-0.7-0.4
Intermitt. access day 15 inactive lever presses0.81.72.2-1.5-1.3-1.3-1.4-1.31.3-1.31.3-1.3-1.2-1.3-1.3-1.3
Intermitt. access escalation Index0.30.50.6-0.7-0.7-0.7-0.8-0.70.7-0.70.7-0.7-0.6-0.7-0.7-0.5
Intermittent access day 1 total infusions0.30.40.50.50.60.60.50.7-0.70.7-0.70.70.70.70.70.6
Intermittent access day 15 total infusions1.42.03.41.11.41.31.51.4-1.41.4-1.41.41.41.51.51.8
Intermittent access terminal intake (last 3 days)2.02.63.41.41.51.51.61.6-1.61.6-1.61.61.61.81.81.8
Intermittent access total infusions0.91.01.30.70.90.91.01.0-1.01.0-1.01.01.11.11.11.1
Intermittent access day 1 locomotion1.92.43.21.31.51.51.41.5-1.51.5-1.51.51.51.81.81.6
Intermittent access day 15 total locomotion0.20.40.80.30.50.50.70.5-0.50.5-0.50.50.50.90.90.9
Intermittent access total locomotion0.91.01.50.70.90.91.11.0-1.01.0-1.01.01.01.21.21.2
Intermittent access standard deviation1.83.84.41.82.02.01.92.0-2.02.0-2.02.01.92.12.11.8
Left kidney weight0.73.44.9-2.2-1.9-1.8-2.1-1.81.8-1.81.8-1.8-1.8-1.6-1.6-1.8
Right kidney weight0.62.94.8-2.2-1.7-1.7-1.9-1.71.7-1.61.6-1.6-1.6-1.5-1.5-1.7
Cocaine induced anxiety2.53.64.0-1.8-1.9-1.9-2.0-1.91.9-1.91.9-1.9-1.9-1.9-1.9-2.0
Post-drug Anxiety5.15.46.1-2.3-2.3-2.3-2.3-2.32.3-2.32.3-2.3-2.3-2.2-2.2-2.5
Baseline Anxiety0.00.00.20.10.20.20.40.2-0.20.2-0.20.20.20.20.20.1
Tail length3.614.217.3-4.2-3.7-3.5-4.0-3.73.7-3.73.7-3.7-3.8-3.7-3.7-3.6
Length with tail5.423.727.5-5.2-4.9-4.8-5.2-4.94.9-4.94.9-4.9-4.9-4.4-4.4-4.8
Length without tail2.47.88.7-2.8-2.9-3.0-2.9-2.92.9-2.92.8-2.8-2.9-2.3-2.3-2.8
Times rat made contact with spout0.40.40.9-0.6-0.7-0.7-0.7-0.60.6-0.60.6-0.6-0.6-0.5-0.5-1.0
Lifetime Intake0.50.60.80.40.70.60.70.7-0.70.7-0.80.80.80.90.90.8
Liver weight, left2.23.74.9-2.1-1.9-1.8-2.2-1.91.9-1.91.9-1.9-1.9-1.9-1.9-1.8
Liver weight, right0.50.81.10.70.90.80.60.9-0.90.9-1.01.01.10.90.91.0
Locomotor activity0.10.10.3-0.4-0.5-0.5-0.2-0.40.4-0.40.4-0.4-0.1-0.1-0.10.4
Locomotor testing distance0.20.30.7-0.6-0.8-0.8-0.1-0.70.7-0.60.6-0.6-0.3-0.3-0.3-0.2
Locomotor testing rearing1.42.84.41.41.31.22.11.5-1.51.5-1.61.51.81.91.92.1
Locomotion in novel chamber3.03.94.6-2.1-2.0-1.9-2.1-1.91.9-1.91.9-1.9-1.8-2.1-2.1-1.8
Locomotion in novel chamber post-restriction0.00.00.20.00.30.4-0.30.2-0.20.1-0.10.10.0-0.2-0.20.3
Fecal boli incidents, locomotor time 11.52.23.41.91.61.71.61.5-1.51.5-1.41.41.21.31.31.4
Change in fecal boli incidents, locomotor task0.20.21.3-1.1-0.4-0.3-0.7-0.30.3-0.30.2-0.20.0-0.3-0.30.2
Time >=10cm from walls, locomotor time 10.50.50.90.30.70.70.60.7-0.70.7-0.70.70.70.80.81.0
Bouts of movement, locomotor time 11.21.42.91.71.31.21.51.2-1.11.1-1.11.10.90.90.91.0
Total resting periods, locomotor time 11.21.42.71.71.31.21.41.2-1.21.1-1.11.11.00.90.91.0
Rest time, locomotor task time 10.20.20.9-0.0-0.3-0.4-0.3-0.40.4-0.40.4-0.4-0.3-0.9-0.9-0.1
Distance moved, locomotor task time 10.20.41.00.30.40.40.40.5-0.50.5-0.60.60.71.01.0-0.2
Vertical activity count, locomotor time 10.30.72.3-0.7-0.9-0.9-0.8-0.90.9-0.80.8-0.8-0.8-0.4-0.4-1.5
Time >=10cm from walls, locomotor time 20.30.40.9-0.5-0.7-0.7-0.5-0.70.7-0.70.7-0.7-0.8-0.1-0.1-1.0
Bouts of movement, locomotor time 21.62.64.1-1.4-1.4-1.3-1.5-1.51.5-1.51.6-1.5-1.7-2.0-2.0-1.7
Total resting periods, locomotor time 21.22.13.9-1.3-1.2-1.2-1.4-1.31.3-1.31.4-1.3-1.5-2.0-2.0-1.5
Rest time, locomotor task time 20.50.62.3-0.5-0.6-0.5-0.8-0.60.6-0.60.6-0.6-0.5-1.5-1.50.2
Distance moved, locomotor task time 20.50.52.00.70.40.30.70.5-0.50.5-0.50.50.51.41.4-0.6
Vertical activity count, locomotor time 20.50.62.8-0.4-0.8-0.8-0.5-0.80.8-0.80.8-0.8-0.9-0.1-0.1-1.7
Light reinforcement 10.00.00.1-0.1-0.0-0.10.20.1-0.10.1-0.10.10.20.10.10.2
Light reinforcement 21.11.72.51.21.51.61.21.4-1.41.3-1.31.31.20.90.91.6
Bone: marrow area0.30.61.00.40.91.00.40.8-0.80.8-0.80.80.50.60.61.0
Bone: maximum diameter0.00.00.2-0.10.10.2-0.30.0-0.0-0.00.1-0.1-0.2-0.5-0.50.1
Bone: maximum force0.10.10.2-0.4-0.10.0-0.3-0.20.2-0.20.3-0.3-0.4-0.5-0.5-0.1
Bone: maximum moment0.00.10.2-0.3-0.00.1-0.3-0.20.2-0.20.2-0.2-0.4-0.5-0.50.0
Mean time between licks in bursts0.61.44.60.51.11.11.01.1-1.11.1-1.11.11.11.21.22.1
Mean num. licks in bursts0.00.00.2-0.2-0.2-0.2-0.0-0.10.1-0.10.1-0.1-0.10.40.4-0.1
Cd content in liver0.00.00.1-0.30.00.0-0.10.0-0.00.0-0.00.00.1-0.1-0.1-0.1
Co content in liver1.11.22.1-1.5-1.2-1.1-1.0-1.11.1-1.11.1-1.1-1.3-0.9-0.9-0.9
Cu content in liver0.50.60.80.70.90.90.70.8-0.80.8-0.80.80.80.60.60.8
Fe content in liver0.50.52.40.70.70.60.50.7-0.70.7-0.70.70.70.40.41.5
K content in liver0.40.40.6-0.8-0.6-0.7-0.6-0.60.6-0.60.6-0.6-0.6-0.2-0.2-0.8
Mg content in liver0.30.31.2-1.1-0.6-0.6-0.5-0.50.5-0.50.5-0.5-0.5-0.1-0.1-0.6
Mn content in liver0.30.30.50.10.50.50.60.5-0.50.5-0.50.50.50.70.70.6
Na content in liver0.00.00.10.20.20.20.20.2-0.20.2-0.20.20.20.20.2-0.0
Rb content in liver0.80.91.2-1.1-1.0-1.0-1.0-1.01.0-1.01.0-0.9-1.0-1.0-1.0-0.6
Se content in liver0.20.20.40.40.60.7-0.20.4-0.40.4-0.40.40.3-0.4-0.40.5
Sr content in liver0.40.41.3-0.4-0.4-0.3-0.5-0.50.5-0.50.5-0.5-0.6-0.7-0.7-1.1
Zn content in liver1.82.03.1-1.6-1.2-1.1-1.7-1.31.2-1.31.3-1.3-1.4-1.8-1.8-1.4
Bone: minimum diameter0.40.81.7-1.3-0.8-0.7-1.1-0.80.8-0.80.8-0.8-0.9-0.9-0.9-0.7
Time in familiar zone, hab. session 10.60.61.20.50.60.51.00.7-0.70.7-0.80.80.91.11.10.1
Time in novel zone, hab. session 10.20.22.00.40.40.5-0.10.3-0.30.2-0.20.20.1-0.1-0.11.4
Total zone transitions, hab. session 10.60.91.00.71.01.01.00.9-0.90.9-0.90.90.90.90.91.0
Total locomotion distance, hab. session 10.00.00.3-0.6-0.2-0.1-0.1-0.20.1-0.20.1-0.1-0.1-0.1-0.10.1
Locomotion velocity, hab. session 10.40.61.3-1.1-0.8-0.7-0.7-0.80.8-0.80.8-0.7-0.7-0.7-0.7-0.5
Time in familiar zone, hab. session 20.70.71.50.50.60.51.00.7-0.70.8-0.80.80.91.21.20.7
Time in novel zone, hab. session 20.10.10.20.10.30.4-0.20.1-0.20.1-0.10.1-0.0-0.3-0.30.5
Total zone transitions, hab. session 20.71.01.41.01.01.11.11.0-1.00.9-0.90.90.80.90.91.2
Total locomotion distance, hab. session 20.40.50.7-0.8-0.6-0.6-0.6-0.70.7-0.70.8-0.8-0.8-0.8-0.8-0.1
Locomotion velocity, hab. session 20.60.71.0-1.0-0.8-0.7-0.8-0.90.9-0.90.9-0.9-1.0-0.9-0.9-0.3
Novel to familiar place preference ratio0.40.41.01.00.70.70.50.6-0.60.6-0.60.50.40.30.30.8
Novelty place preference0.20.20.60.80.50.60.40.5-0.50.5-0.40.40.30.20.20.7
Time in novel zone, NPP test0.20.20.70.70.50.50.40.4-0.40.4-0.40.40.30.10.10.8
Total zone transitions, NPP test0.20.32.50.40.50.60.40.4-0.40.4-0.40.40.30.30.31.6
Total locomotion distance, NPP test0.10.11.1-0.2-0.10.1-0.2-0.20.2-0.20.2-0.2-0.2-0.3-0.31.1
Locomotion velocity, NPP test0.10.10.5-0.3-0.1-0.0-0.2-0.20.2-0.30.3-0.3-0.3-0.4-0.40.7
Intraocular pressure0.10.10.20.40.20.10.30.2-0.20.2-0.20.20.20.40.40.3
Delta distance traveled before/after self-admin0.00.00.2-0.10.10.20.40.1-0.10.1-0.10.1-0.0-0.0-0.0-0.1
Delta ambulatory time before/after self-admin0.50.60.8-0.9-0.7-0.6-0.4-0.70.7-0.70.7-0.7-0.8-0.9-0.9-0.9
Parametrial fat weight0.40.91.41.01.11.10.61.0-1.01.0-1.01.00.90.90.91.2
Pavlov. Cond. lever latency0.50.61.2-1.1-0.8-0.8-0.9-0.80.8-0.80.8-0.8-0.7-0.8-0.8-0.5
Pavlov. Cond. magazine entry latency0.60.71.21.10.80.81.10.8-0.80.8-0.80.80.80.90.9-0.1
Pavlov. Cond. change in total contacts0.30.30.60.70.50.40.80.5-0.50.6-0.60.60.60.70.7-0.2
Pavlov. Cond. index score0.91.12.11.41.11.01.21.1-1.01.0-1.01.00.91.01.00.2
Pavlov. Cond. latency score0.60.71.51.20.80.81.00.8-0.80.8-0.80.80.70.80.80.1
Pavlov. Cond. lever contacts1.01.22.11.41.11.01.21.1-1.11.1-1.11.11.01.11.10.6
Pavlov. Cond. magazine entry number1.01.21.8-1.3-1.1-1.1-1.3-1.11.1-1.11.1-1.1-1.1-1.2-1.20.1
Pavlov. Cond. intertrial magazine entries5.46.57.9-2.8-2.6-2.5-2.7-2.62.6-2.62.6-2.6-2.5-2.6-2.6-1.8
Pavlov. Cond. lever-magazine prob. diff.0.70.91.81.31.00.91.10.9-0.90.9-0.90.90.80.90.90.2
Pavlov. Cond. response bias1.62.02.51.61.41.41.61.4-1.41.4-1.41.41.31.41.40.6
Pavlov. Cond. lever latency2.23.03.7-1.3-1.9-1.9-1.7-1.81.8-1.81.8-1.8-1.7-1.8-1.8-1.5
Pavlov. Cond. magazine entry latency4.55.46.22.12.52.52.22.5-2.52.5-2.52.52.52.22.21.4
Pavlov. Cond. change in total contacts3.45.46.22.12.42.32.42.4-2.42.4-2.42.42.52.42.41.6
Pavlov. Cond. index score4.86.47.22.12.72.72.52.7-2.72.7-2.72.72.72.52.51.9
Pavlov. Cond. latency score4.86.37.02.12.62.62.42.6-2.62.6-2.72.72.72.52.51.9
Pavlov. Cond. lever contacts2.94.14.91.62.22.22.02.1-2.12.1-2.12.12.02.02.01.7
Pavlov. Cond. magazine entry number4.25.26.2-1.9-2.3-2.3-2.2-2.42.4-2.42.4-2.4-2.5-2.4-2.4-1.6
Pavlov. Cond. intertrial magazine entries4.26.37.7-2.7-2.7-2.8-2.4-2.72.7-2.62.6-2.6-2.6-2.1-2.1-1.7
Pavlov. Cond. lever-magazine prob. diff.5.47.18.22.22.82.82.62.8-2.82.8-2.82.82.92.72.72.0
Pavlov. Cond. response bias3.95.35.91.72.42.42.32.4-2.42.4-2.42.42.42.32.31.8
Time in closed arm before self-admin1.82.33.11.71.61.51.51.5-1.51.5-1.51.51.51.21.21.8
Time in closed arm after self-admin0.70.81.00.80.90.90.90.9-0.90.9-0.90.91.00.60.61.0
Time in open arm before self-admin2.22.43.5-1.9-1.6-1.6-1.7-1.51.5-1.51.5-1.5-1.5-1.3-1.3-1.4
Time in open arm after self-admin2.02.23.1-1.4-1.5-1.5-1.6-1.51.5-1.51.5-1.5-1.5-1.1-1.1-1.8
Bone: periosteal estimation0.00.10.3-0.50.00.2-0.5-0.10.1-0.10.2-0.2-0.4-0.4-0.40.1
Bone: periosteal perimeter0.00.10.2-0.40.20.3-0.40.0-0.00.00.0-0.0-0.2-0.4-0.40.3
Bone: post-yield work1.11.61.9-1.3-1.2-1.2-1.3-1.21.2-1.21.3-1.2-1.2-1.4-1.4-1.2
Progressive ratio test 1 active lever presses0.20.30.60.20.40.40.50.5-0.50.5-0.50.50.60.80.80.7
Progressive ratio test 1 breakpoint0.40.50.80.30.50.50.70.6-0.60.6-0.70.70.70.90.90.8
Progressive ratio test 1 inactive lever presses1.11.62.1-1.4-1.4-1.4-1.3-1.31.3-1.31.3-1.3-1.3-1.1-1.1-0.8
Progressive ratio test 2 active lever presses0.10.10.2-0.5-0.3-0.3-0.4-0.30.3-0.30.3-0.3-0.2-0.4-0.4-0.0
Progressive ratio test 2 breakpoint0.10.10.2-0.5-0.3-0.3-0.4-0.30.3-0.30.3-0.3-0.2-0.4-0.4-0.0
Progressive ratio test 2 inactive lever presses0.71.21.6-1.3-1.1-1.2-1.1-1.11.1-1.01.0-1.0-0.9-1.2-1.2-0.7
Incentive Sensitization - Responses0.10.20.5-0.4-0.4-0.4-0.6-0.40.4-0.40.4-0.4-0.3-0.7-0.7-0.2
Incentive Sensitization - Breakpoint0.20.30.6-0.5-0.5-0.5-0.7-0.40.4-0.40.4-0.4-0.4-0.8-0.8-0.3
Sum of active levers in priming session hrs 5-60.10.10.3-0.3-0.3-0.30.0-0.30.3-0.30.3-0.3-0.4-0.2-0.2-0.6
Progressive ratio0.10.20.6-0.8-0.4-0.3-0.6-0.40.4-0.40.4-0.4-0.4-0.2-0.2-0.7
Food seeking constrained by brief footshock2.02.43.0-1.2-1.5-1.5-1.4-1.61.6-1.61.6-1.6-1.7-1.7-1.7-1.6
Seeking ratio, punishment vs. effort0.10.20.40.1-0.4-0.4-0.1-0.40.4-0.40.4-0.4-0.4-0.6-0.6-0.2
Retroperitoneal fat weight0.10.40.60.60.70.70.30.7-0.70.7-0.70.70.60.50.50.8
Reaction time number correct2.24.25.5-2.1-2.3-2.3-1.9-2.12.2-2.12.1-2.1-2.0-1.9-1.9-1.4
Reaction time mean minus median0.10.20.60.60.40.40.10.3-0.30.3-0.30.30.30.20.20.8
Reaction time mean minus median AUC0.10.20.90.40.40.50.10.4-0.40.4-0.30.30.30.10.11.0
Reaction time num false alarms0.91.21.7-1.3-1.2-1.3-1.0-1.11.1-1.11.1-1.1-0.9-0.9-0.9-1.2
Reaction time num false alarms AUC1.21.92.5-1.6-1.5-1.5-1.4-1.41.4-1.41.4-1.4-1.2-1.3-1.3-1.2
Reaction time trials correct on left2.24.25.5-2.1-2.3-2.3-1.9-2.12.2-2.12.1-2.1-2.0-1.9-1.9-1.4
Reaction time trials on left2.24.25.4-2.1-2.3-2.3-1.9-2.12.1-2.12.1-2.1-2.0-1.9-1.9-1.4
Reaction time mean0.71.21.41.01.11.21.01.1-1.11.1-1.11.11.11.11.11.2
Reaction time mean AUC0.50.81.30.80.91.00.70.9-0.90.9-0.90.90.90.80.81.2
Median of all reaction times0.50.70.90.60.90.90.80.9-0.90.9-0.90.90.90.90.90.9
Reaction time omissions0.30.50.8-0.5-0.6-0.6-0.8-0.70.7-0.70.7-0.7-0.8-0.9-0.90.1
Reaction time false alarm rate0.10.10.3-0.5-0.3-0.3-0.4-0.30.3-0.30.3-0.3-0.2-0.3-0.3-0.6
Reaction time premature initiation rate0.91.31.9-1.4-1.2-1.2-1.1-1.11.1-1.11.1-1.1-1.1-1.1-1.1-1.2
Reaction time premature initiations2.13.84.7-2.2-2.1-2.1-1.8-2.02.0-2.01.9-1.9-1.9-1.8-1.8-1.6
Std. dev. reaction times0.20.41.20.70.70.80.30.6-0.60.6-0.60.60.50.40.41.1
Reaction time trials completed2.24.25.4-2.1-2.3-2.3-1.9-2.12.1-2.12.1-2.1-2.0-1.9-1.9-1.4
Reaction time trials AUC2.34.56.0-2.2-2.4-2.4-2.0-2.22.2-2.22.2-2.2-2.1-1.9-1.9-1.4
Run reversals in cocaine runway, females0.60.61.11.00.70.70.90.7-0.80.8-0.70.70.90.60.60.7
Run reversals in cocaine runway, males1.01.11.4-0.9-1.0-1.0-1.0-1.01.0-1.01.1-1.1-1.2-1.0-1.0-0.8
Latency to leave start box in cocaine runway0.10.10.30.00.30.20.60.3-0.30.4-0.40.40.30.30.30.3
Latency to leave start box in cocaine runway, F0.10.10.50.10.20.00.70.2-0.20.3-0.30.30.20.40.40.1
Latency to leave start box in cocaine runway, M0.00.00.1-0.10.20.20.10.3-0.30.3-0.30.30.2-0.1-0.10.3
Std. dev. time between licks in bursts0.81.01.90.51.01.11.01.0-1.00.9-0.90.90.91.21.21.4
Total sessions with >9 infusions0.30.40.70.20.50.50.60.6-0.60.6-0.60.60.60.90.90.7
Short access day 1 total inactive lever presses0.00.00.1-0.3-0.1-0.10.0-0.00.0-0.0-0.00.00.1-0.2-0.20.2
Short access day 10 total inactive lever presses0.00.00.1-0.00.10.1-0.10.1-0.10.1-0.10.10.10.10.10.3
Short access day 1 total infusions0.20.20.6-0.8-0.5-0.5-0.5-0.50.5-0.40.4-0.4-0.4-0.3-0.3-0.5
Short access day 10 total infusions0.91.11.60.80.90.90.91.0-1.01.0-1.01.01.11.21.21.3
Short access total infusions0.20.30.50.20.50.50.50.5-0.50.5-0.50.50.60.70.70.5
Short access day 1 locomotion0.40.50.80.30.60.50.80.6-0.60.7-0.70.70.80.90.90.8
Short access day 10 total locomotion2.03.85.41.71.81.72.11.8-1.81.8-1.81.81.92.32.32.1
Short access total locomotion0.50.61.40.30.60.50.80.6-0.60.6-0.60.60.71.11.11.2
One hour access (0.3 mA shock)0.10.10.3-0.4-0.2-0.2-0.2-0.20.2-0.20.2-0.2-0.1-0.2-0.20.5
Compulsive drug intake0.00.00.0-0.1-0.1-0.1-0.2-0.10.1-0.10.1-0.1-0.1-0.1-0.10.1
One hour access (shock baseline)0.00.00.1-0.3-0.1-0.10.0-0.10.1-0.10.1-0.0-0.0-0.0-0.00.1
Social response proportion0.30.30.7-0.8-0.6-0.6-0.8-0.50.5-0.50.5-0.5-0.3-0.5-0.5-0.8
Social responses0.00.00.10.10.10.1-0.00.2-0.20.2-0.20.20.30.00.00.1
Social time0.91.22.4-1.2-1.0-0.9-1.5-1.01.0-1.01.0-1.0-1.0-1.6-1.6-0.1
Soleus weight0.00.10.3-0.20.30.30.20.4-0.40.4-0.40.40.50.50.50.3
Bone: stiffness0.91.52.0-1.3-1.0-0.9-1.4-1.21.1-1.21.2-1.2-1.3-1.4-1.4-1.0
Tibialis anterior weight0.20.71.0-1.0-0.8-0.8-0.9-0.80.8-0.80.8-0.8-0.8-0.7-0.7-0.8
Time to tail flick, vehicle, before self-admin0.30.30.5-0.3-0.5-0.5-0.5-0.60.6-0.60.6-0.6-0.6-0.7-0.70.2
Time to tail flick, vehicle, after self-admin0.50.60.90.90.70.80.70.7-0.70.7-0.70.70.80.80.80.9
Time to tail flick, test, before self-admin0.00.00.20.0-0.0-0.00.0-0.00.1-0.10.1-0.1-0.20.00.00.4
Time to tail flick, test, after self-admin0.70.71.1-0.8-0.9-0.8-0.9-0.90.9-0.90.9-0.9-0.8-1.0-1.0-0.3
Delta time to tail flick, vehicle, before/after SA0.00.00.10.20.10.10.20.2-0.20.2-0.20.20.20.40.40.1
Delta time to tail flick, test, before/after SA0.50.51.1-0.7-0.7-0.6-0.8-0.60.6-0.60.6-0.6-0.5-1.0-1.0-0.6
Tibia length0.51.32.0-0.8-1.0-0.9-1.3-1.11.1-1.21.2-1.2-1.4-1.3-1.3-1.0
Ambulatory time before self-admin0.50.71.00.80.70.60.60.8-0.80.9-0.90.90.91.01.00.8
Ambulatory time after self-admin0.10.10.20.20.40.30.40.4-0.40.4-0.40.40.30.30.30.3
Bone: tissue strength0.30.30.7-0.1-0.4-0.3-0.4-0.50.5-0.50.5-0.5-0.6-0.8-0.8-0.4
Total heroin consumption2.42.83.7-1.6-1.7-1.7-1.4-1.81.8-1.81.8-1.8-1.9-1.5-1.5-1.4
Bone: trabecular number0.00.00.00.1-0.0-0.0-0.00.0-0.00.0-0.00.00.10.20.20.0
Bone: trabecular spacing0.00.00.1-0.00.10.2-0.20.0-0.10.0-0.00.0-0.1-0.2-0.20.1
Bone: trabecular thickness0.10.10.10.30.20.20.40.2-0.20.2-0.20.20.20.30.30.2
Bone: trabecular tissue density0.10.10.3-0.1-0.4-0.5-0.0-0.30.3-0.30.3-0.3-0.10.10.1-0.5
Water consumed over 24 hours2.53.44.0-2.0-1.9-1.9-2.0-1.81.8-1.81.8-1.8-1.8-1.7-1.7-1.8
Number of responses in last shaping day0.20.20.60.40.50.60.30.4-0.40.4-0.40.40.30.40.40.7