Hub : Genes

Coa8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Coa8 0.15 0.1 4.5e-14 0.14 0.15 0.15 0.15 8.3e-13 9.1e-14 5.9e-14 8.2e-14
2 NAcc gene expression Coa8 0.12 0.1 7.7e-11 0.1 0.1 0.09 0.1 1.8e-11 4.0e-11 1.1e-10 2.6e-11
3 OFC mRNA stability Coa8 0.62 0.23 8.4e-05 0.08 0.08 0.02 0.08 6.7e-03 5.3e-03 1.0e-01 5.6e-03
4 Adipose gene expression Coa8 0.12 0.12 6.6e-07 0.04 0.04 0.04 0.04 7.9e-06 1.7e-05 2.4e-05 1.2e-05
5 Liver gene expression Coa8 0.29 0.21 7.9e-12 0.07 0.09 0.08 0.07 4.0e-08 6.7e-10 5.2e-09 1.1e-08
6 PL gene expression Coa8 0.07 0.07 3.8e-07 0.06 0.06 0.05 0.06 3.6e-07 2.8e-07 2.0e-06 3.6e-07
7 pVTA gene expression Coa8 0.11 0.1 4.6e-04 0.07 0.07 0.07 0.07 4.0e-04 5.4e-04 7.0e-04 6.7e-04
8 BLA gene expression Coa8 0.12 0.1 2.2e-06 0.12 0.12 0.12 0.11 5.7e-07 7.3e-07 9.6e-07 1.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.10.2-0.5-0.20.3-0.40.30.2-0.4-0.1
Area under the delay curve0.10.10.2-0.3-0.20.2-0.20.10.2-0.4-0.4
BMI with tail2.16.98.0-2.5-2.72.8-2.72.72.8-1.9-2.7
BMI without tail0.51.01.6-0.4-1.11.3-1.21.31.2-0.0-0.9
Body weight0.20.81.71.20.8-0.70.7-0.7-0.61.30.7
Weight adjusted by age0.00.00.10.20.1-0.10.0-0.1-0.10.40.2
Bone surface0.10.10.2-0.4-0.20.3-0.40.40.3-0.10.0
Bone volume0.10.10.2-0.4-0.20.3-0.40.30.3-0.4-0.1
Breakpoint value in progressive ratio session0.00.00.1-0.3-0.10.1-0.00.10.1-0.40.0
Number of licking bursts0.10.10.20.20.2-0.20.3-0.2-0.20.40.4
Context. condit. distance diff. score1.62.02.31.41.4-1.51.4-1.4-1.51.01.5
Locomotion velocity, session 10.20.20.60.30.3-0.40.4-0.3-0.40.80.7
Locomotion distance, session 10.50.71.3-1.1-0.90.8-0.80.80.7-0.9-0.4
Locomotion velocity, session 20.00.00.30.00.1-0.20.0-0.2-0.1-0.60.1
Locomotion distance, session 20.40.60.8-0.9-0.70.7-0.70.70.7-0.9-0.6
Locomotion velocity, session 30.20.30.8-0.7-0.40.3-0.40.30.4-0.9-0.3
Locomotion distance, session 30.00.00.00.00.1-0.10.1-0.1-0.1-0.00.2
Stereotopy head waving bouts, day 30.10.20.30.20.4-0.40.4-0.4-0.40.10.6
Stereotopy head waving duration, day 30.20.30.40.40.5-0.60.6-0.6-0.50.30.7
Locomotion velocity, session 70.40.41.2-0.9-0.40.4-0.40.30.4-1.1-0.7
Locomotion distance, session 70.91.21.6-1.2-1.01.0-1.01.01.0-1.2-1.2
Stereotopy head waving bouts, day 71.11.21.31.11.0-1.11.2-1.1-1.11.01.1
Stereotopy head waving duration, day 70.40.50.50.70.6-0.70.7-0.7-0.70.60.7
Locomotion velocity, session 80.20.20.30.30.5-0.50.6-0.5-0.5-0.00.4
Locomotion distance, session 80.10.10.5-0.4-0.20.2-0.20.30.2-0.7-0.1
Degree of sensitization distance0.10.10.3-0.6-0.30.3-0.30.20.3-0.4-0.5
Degree of sensitization stereotypy0.20.20.30.50.4-0.50.4-0.5-0.50.60.5
Conditioned locomotion1.21.41.61.11.2-1.31.2-1.3-1.30.91.2
Cocaine response after cond. corrected0.50.60.6-0.7-0.80.8-0.80.80.8-0.6-0.7
Cocaine response after cond. not corrected1.82.02.2-1.3-1.41.5-1.51.41.4-1.3-1.5
Cocaine response before conditioning2.32.83.4-1.5-1.71.7-1.71.61.7-1.9-1.8
Saline control response0.20.30.6-0.4-0.50.5-0.50.60.5-0.8-0.5
Bone: connectivity density0.00.00.10.10.2-0.30.1-0.2-0.20.10.2
Bone: cortical apparent density8.711.412.43.43.4-3.53.4-3.5-3.53.03.4
Bone: cortical area0.91.42.01.21.2-1.01.1-1.0-1.11.41.4
Bone: cortical porosity0.00.00.2-0.10.1-0.0-0.0-0.0-0.0-0.40.2
Bone: cortical porosity0.30.30.7-0.5-0.50.5-0.60.60.5-0.8-0.4
Bone: cortical thickness0.81.32.11.01.2-1.11.0-1.1-1.20.91.4
Bone: cortical thickness0.60.70.90.90.9-0.80.8-0.8-0.90.70.9
Bone: cortical tissue density8.811.612.53.43.5-3.53.4-3.5-3.53.03.4
Condit. Reinf. active minus inactive responses0.50.60.6-0.7-0.80.8-0.80.80.8-0.6-0.7
Condit. Reinf. active-inactive response ratio2.52.73.0-1.6-1.71.7-1.71.71.7-1.4-1.6
Condit. Reinf. active responses0.10.20.3-0.3-0.50.4-0.40.40.4-0.5-0.4
Condit. Reinf. inactive responses1.72.12.51.41.4-1.51.4-1.5-1.51.21.6
Incentive salience index mean0.50.60.7-0.8-0.80.8-0.80.80.8-0.6-0.6
Condit. Reinf. lever presses0.10.20.4-0.6-0.40.3-0.40.30.3-0.5-0.1
Condit. Reinf. active minus inactive responses0.40.40.60.60.7-0.70.8-0.7-0.70.60.7
Condit. Reinf. active-inactive response ratio0.40.50.70.50.6-0.70.8-0.7-0.70.80.7
Condit. Reinf. active responses0.00.00.10.10.0-0.00.1-0.00.0-0.2-0.1
Condit. Reinf. inactive responses0.60.71.2-0.4-0.80.8-0.90.80.9-1.1-1.0
Condit. Reinf. lever presses1.62.12.7-1.1-1.51.5-1.41.51.5-1.6-1.4
Condit. Reinf. lever reinforcers received0.00.00.10.20.0-0.00.1-0.00.0-0.2-0.1
Conditioned reinforcement - actives2.12.12.61.61.4-1.51.4-1.5-1.51.31.4
Conditioned reinforcement - inactives0.30.40.60.80.6-0.60.6-0.6-0.60.50.6
Conditioned locomotion0.91.02.2-0.9-1.00.9-1.00.90.9-1.5-0.9
Patch foraging indifference point 0 sec3.76.07.32.62.5-2.62.7-2.6-2.52.02.1
Patch foraging indifference point AUC2.52.93.41.41.8-1.81.5-1.9-1.81.41.8
Delay disc. indifference point, 0s delay0.10.10.20.30.3-0.40.5-0.4-0.30.10.1
Delay disc. indifference point, 16s delay0.00.00.1-0.1-0.20.10.20.10.1-0.3-0.1
Delay disc. indifference point, 2s delay0.10.10.2-0.4-0.30.3-0.30.20.3-0.1-0.2
Delay disc. indifference point, 24s delay0.10.10.2-0.3-0.30.3-0.50.30.30.1-0.1
Delay disc. indifference point, 4s delay0.10.10.20.30.4-0.50.4-0.5-0.40.00.0
Delay disc. indifference point, 8s delay0.20.20.5-0.5-0.40.3-0.40.30.4-0.7-0.6
Indifference point function ln k0.50.71.11.10.8-0.80.7-0.7-0.80.80.8
Indifference point function log k0.50.71.11.10.8-0.80.7-0.7-0.80.80.8
Patch foraging total patch changes 0 sec4.16.78.32.72.6-2.72.9-2.8-2.62.12.2
Patch foraging total patch changes 12 sec3.95.06.22.12.4-2.42.3-2.5-2.31.72.1
Patch foraging total patch changes 18 sec1.62.13.20.91.6-1.71.5-1.8-1.60.51.4
Patch foraging total patch changes 24 sec0.20.30.50.50.6-0.60.6-0.7-0.60.40.3
Patch foraging total patch changes 6 sec2.53.74.72.21.9-2.02.1-2.0-1.91.71.5
Patch foraging time to switch 0 sec10.916.917.8-4.2-4.24.2-4.14.24.2-3.7-4.1
Patch foraging water rate 0 sec19.631.434.25.85.7-5.75.6-5.7-5.75.25.4
Patch foraging water rate 12 sec10.115.419.74.43.8-3.83.9-3.8-3.84.23.7
Patch foraging water rate 18 sec5.47.29.33.02.5-2.62.6-2.6-2.63.12.5
Patch foraging water rate 24 sec4.15.77.32.72.4-2.32.4-2.2-2.32.62.3
Patch foraging water rate 6 sec4.76.98.32.92.8-2.72.6-2.7-2.72.22.5
Seeking ratio, delayed vs. immediate footshock0.20.30.90.10.4-0.50.3-0.4-0.50.61.0
Distance traveled before self-admin0.00.00.1-0.0-0.10.1-0.10.10.10.0-0.3
Distance traveled after self-admin0.40.50.70.80.7-0.70.8-0.7-0.70.50.7
Extensor digitorum longus weight5.722.624.95.04.7-4.74.7-4.7-4.84.65.0
Bone: elastic displacement0.50.50.70.60.8-0.80.8-0.7-0.80.40.8
Bone: elastic work0.10.10.20.30.3-0.20.3-0.2-0.30.20.5
Bone: endosteal estimation0.20.40.6-0.4-0.60.8-0.60.80.70.1-0.5
Bone: endosteal perimeter0.10.10.70.3-0.10.2-0.10.30.20.90.0
Epididymis fat weight4.29.812.1-3.0-3.23.2-3.23.23.2-2.7-3.5
Delta time in closed arm before/after self-admin0.00.00.10.1-0.30.2-0.20.20.2-0.2-0.3
Delta time in open arm before/after self-admin0.60.51.00.90.7-0.70.6-0.7-0.71.00.7
Diff in mean of infusions in LGA sessions0.10.10.2-0.20.2-0.20.2-0.2-0.2-0.50.2
Delay discount exponential model param0.00.00.10.20.2-0.10.2-0.1-0.20.30.3
Extinction: sum of active levers before priming0.10.10.4-0.4-0.10.10.00.10.1-0.6-0.0
Active lever presses in extinction session 61.21.21.71.11.1-1.11.3-1.0-1.10.81.1
Bone: final force0.20.40.60.70.6-0.50.4-0.4-0.60.80.7
Bone: final moment0.30.40.80.80.7-0.50.5-0.4-0.60.90.8
Food consumed during 24 hour testing period0.10.10.50.70.2-0.30.4-0.3-0.30.30.4
Glucose0.91.41.61.11.1-1.21.2-1.3-1.21.11.1
Heart weight0.00.00.20.10.00.0-0.10.00.1-0.4-0.1
Delay discount hyperbolic model param0.10.10.10.30.2-0.20.3-0.1-0.20.40.3
Intermittent access intake day 1-15 change1.51.52.8-1.2-1.11.1-1.21.11.1-1.7-1.1
Intermittent access intake escalation1.81.83.3-1.3-1.21.2-1.31.21.2-1.8-1.2
Intermittent access intake escalation 20.20.20.6-0.5-0.40.4-0.40.40.4-0.8-0.2
Intermitt. access day 1 inactive lever presses2.72.93.51.91.7-1.71.7-1.7-1.71.61.6
Intermitt. access day 15 inactive lever presses1.11.21.71.31.0-1.01.2-1.0-1.01.20.9
Intermitt. access escalation Index0.40.40.90.60.5-0.60.6-0.6-0.60.90.4
Intermittent access day 1 total infusions0.30.40.5-0.4-0.70.6-0.70.70.7-0.4-0.7
Intermittent access day 15 total infusions1.82.02.4-1.3-1.41.4-1.51.41.4-1.6-1.5
Intermittent access terminal intake (last 3 days)2.02.22.5-1.2-1.51.5-1.61.41.5-1.5-1.6
Intermittent access total infusions0.70.71.0-0.6-0.80.8-0.90.80.9-0.9-1.0
Intermittent access day 1 locomotion0.91.01.2-0.7-1.01.0-1.11.01.0-1.0-1.0
Intermittent access day 15 total locomotion0.40.51.0-0.6-0.60.6-0.70.60.6-1.0-0.6
Intermittent access total locomotion0.50.61.3-0.7-0.70.7-0.80.70.7-1.1-0.7
Intermittent access standard deviation3.73.95.2-1.9-1.91.9-2.01.91.9-2.3-1.9
Left kidney weight0.72.02.91.71.4-1.41.4-1.4-1.41.31.2
Right kidney weight0.41.12.01.41.0-1.00.8-0.9-0.91.30.8
Cocaine induced anxiety3.23.64.32.01.9-1.81.9-1.8-1.92.11.9
Post-drug Anxiety2.73.03.31.81.7-1.71.8-1.7-1.71.81.7
Baseline Anxiety1.61.72.0-1.4-1.31.3-1.31.31.3-1.4-1.3
Tail length3.39.913.53.73.1-3.03.0-2.9-3.03.33.1
Length with tail4.215.418.24.34.0-4.03.9-3.9-3.93.63.7
Length without tail1.84.05.01.82.2-2.22.1-2.2-2.21.21.8
Times rat made contact with spout0.40.40.60.60.6-0.70.8-0.7-0.70.60.7
Lifetime Intake0.30.30.5-0.3-0.60.6-0.60.60.6-0.7-0.7
Liver weight, left3.25.16.22.52.3-2.12.2-2.1-2.22.52.2
Liver weight, right0.00.10.30.30.2-0.10.1-0.1-0.10.50.1
Locomotor activity0.10.10.20.50.4-0.50.4-0.5-0.4-0.10.1
Locomotor testing distance0.30.50.80.70.8-0.90.8-0.9-0.8-0.20.5
Locomotor testing rearing1.42.25.7-1.6-1.21.2-1.21.11.2-2.4-1.6
Locomotion in novel chamber5.77.19.73.12.7-2.62.7-2.5-2.52.72.4
Locomotion in novel chamber post-restriction0.10.20.3-0.1-0.50.5-0.50.60.40.2-0.1
Fecal boli incidents, locomotor time 12.12.34.0-2.0-1.61.6-1.41.61.5-1.3-1.0
Change in fecal boli incidents, locomotor task0.40.41.41.20.5-0.50.8-0.5-0.50.20.0
Time >=10cm from walls, locomotor time 10.40.40.5-0.4-0.70.7-0.50.70.7-0.7-0.7
Bouts of movement, locomotor time 11.41.53.1-1.8-1.31.3-1.21.21.2-1.0-0.7
Total resting periods, locomotor time 11.31.52.7-1.6-1.31.3-1.21.21.2-1.0-0.8
Rest time, locomotor task time 10.20.20.50.20.4-0.40.3-0.4-0.40.70.7
Distance moved, locomotor task time 10.30.30.6-0.3-0.40.4-0.50.40.5-0.8-0.8
Vertical activity count, locomotor time 10.60.60.90.70.9-0.90.9-0.9-0.90.60.6
Time >=10cm from walls, locomotor time 20.60.60.90.50.8-0.80.8-0.8-0.80.60.9
Bouts of movement, locomotor time 22.12.33.51.51.3-1.31.5-1.3-1.41.91.8
Total resting periods, locomotor time 21.71.82.91.51.2-1.11.3-1.1-1.21.71.5
Rest time, locomotor task time 20.50.51.51.10.5-0.50.6-0.5-0.51.20.5
Distance moved, locomotor task time 20.30.30.9-0.9-0.30.3-0.50.30.4-1.0-0.5
Vertical activity count, locomotor time 20.40.50.70.30.8-0.80.5-0.8-0.80.40.8
Light reinforcement 10.00.00.00.1-0.00.00.00.00.10.1-0.2
Light reinforcement 21.62.12.8-1.3-1.61.6-1.51.71.6-0.9-1.3
Bone: marrow area0.10.30.5-0.4-0.60.7-0.60.70.70.1-0.4
Bone: maximum diameter0.10.10.70.40.2-0.10.2-0.1-0.20.80.4
Bone: maximum force0.30.40.70.70.7-0.50.6-0.5-0.60.80.8
Bone: maximum moment0.20.40.70.70.6-0.50.5-0.4-0.50.80.8
Mean time between licks in bursts1.01.52.3-1.0-1.31.2-1.11.21.2-1.5-1.2
Mean num. licks in bursts0.00.00.00.10.0-0.20.1-0.2-0.1-0.10.0
Cd content in liver0.40.41.31.10.5-0.50.6-0.4-0.50.70.3
Co content in liver0.70.81.00.81.0-1.01.0-0.9-1.00.50.9
Cu content in liver1.01.21.8-0.9-1.21.1-1.11.11.1-0.9-1.4
Fe content in liver0.10.10.4-0.4-0.40.4-0.20.30.3-0.1-0.6
K content in liver0.10.10.20.10.3-0.40.4-0.4-0.4-0.00.2
Mg content in liver0.10.10.20.20.3-0.40.3-0.4-0.4-0.20.4
Mn content in liver0.00.10.2-0.10.1-0.20.1-0.1-0.1-0.50.3
Na content in liver0.00.00.1-0.4-0.20.1-0.10.10.1-0.30.2
Rb content in liver0.70.81.00.81.0-1.01.0-1.0-1.00.90.6
Se content in liver0.20.20.30.2-0.50.5-0.60.50.40.6-0.2
Sr content in liver0.40.30.80.90.5-0.40.4-0.3-0.40.90.4
Zn content in liver0.20.20.40.60.4-0.40.5-0.4-0.40.50.5
Bone: minimum diameter0.81.42.21.41.2-1.11.1-1.0-1.11.51.2
Time in familiar zone, hab. session 10.60.61.7-1.0-0.50.5-0.50.50.6-1.3-0.8
Time in novel zone, hab. session 10.20.20.60.0-0.50.4-0.40.50.40.8-0.3
Total zone transitions, hab. session 10.71.01.2-1.1-1.01.0-0.91.00.9-1.1-0.9
Total locomotion distance, hab. session 10.00.00.10.30.1-0.10.2-0.1-0.1-0.10.0
Locomotion velocity, hab. session 10.40.50.70.80.7-0.70.8-0.7-0.70.30.7
Time in familiar zone, hab. session 20.60.61.9-0.9-0.50.5-0.50.50.6-1.4-1.0
Time in novel zone, hab. session 20.10.10.30.2-0.40.3-0.40.40.30.5-0.0
Total zone transitions, hab. session 20.91.11.6-1.3-1.11.1-1.01.11.0-1.2-0.9
Total locomotion distance, hab. session 20.30.40.50.60.6-0.60.7-0.6-0.60.30.7
Locomotion velocity, hab. session 20.40.60.70.70.8-0.80.9-0.7-0.80.50.9
Novel to familiar place preference ratio0.40.40.5-0.7-0.60.7-0.70.70.6-0.4-0.5
Novelty place preference0.20.20.3-0.5-0.50.5-0.50.50.5-0.3-0.4
Time in novel zone, NPP test0.20.20.3-0.4-0.40.5-0.50.50.5-0.2-0.3
Total zone transitions, NPP test0.20.30.4-0.5-0.60.5-0.50.60.5-0.6-0.2
Total locomotion distance, NPP test0.00.00.10.3-0.0-0.00.10.0-0.10.10.2
Locomotion velocity, NPP test0.00.00.10.30.0-0.10.1-0.0-0.10.10.3
Intraocular pressure0.10.10.2-0.3-0.30.3-0.40.30.3-0.2-0.2
Delta distance traveled before/after self-admin0.00.00.30.10.1-0.10.2-0.0-0.1-0.50.2
Delta ambulatory time before/after self-admin0.40.50.70.70.7-0.70.8-0.6-0.70.20.8
Parametrial fat weight0.00.00.20.0-0.00.1-0.20.10.10.4-0.1
Pavlov. Cond. lever latency0.60.80.90.90.9-0.90.9-0.9-0.90.90.7
Pavlov. Cond. magazine entry latency0.50.71.3-1.1-0.70.7-0.70.70.7-1.0-0.5
Pavlov. Cond. change in total contacts0.30.30.7-0.7-0.40.4-0.40.40.5-0.8-0.4
Pavlov. Cond. index score0.91.21.7-1.3-1.11.1-1.11.11.1-1.1-0.8
Pavlov. Cond. latency score0.60.81.2-1.1-0.80.9-0.80.90.9-0.9-0.6
Pavlov. Cond. lever contacts0.80.91.3-1.1-1.01.0-1.01.01.0-1.0-0.7
Pavlov. Cond. magazine entry number1.11.31.71.31.1-1.21.2-1.2-1.21.30.9
Pavlov. Cond. intertrial magazine entries5.46.57.42.72.5-2.62.6-2.5-2.62.42.4
Pavlov. Cond. lever-magazine prob. diff.0.70.81.3-1.1-0.91.0-0.90.90.9-0.9-0.6
Pavlov. Cond. response bias1.21.51.9-1.4-1.21.2-1.21.21.2-1.4-0.9
Pavlov. Cond. lever latency2.33.13.91.51.8-1.81.8-1.8-1.82.01.6
Pavlov. Cond. magazine entry latency4.75.56.2-2.0-2.52.4-2.52.42.4-2.0-2.4
Pavlov. Cond. change in total contacts4.15.66.3-2.2-2.42.3-2.32.32.4-2.5-2.4
Pavlov. Cond. index score5.06.46.9-2.2-2.62.6-2.62.62.6-2.5-2.6
Pavlov. Cond. latency score4.96.16.6-2.2-2.62.5-2.62.52.5-2.4-2.5
Pavlov. Cond. lever contacts3.24.44.9-1.8-2.22.2-2.12.22.1-2.2-1.9
Pavlov. Cond. magazine entry number3.84.65.11.92.2-2.22.2-2.1-2.22.12.3
Pavlov. Cond. intertrial magazine entries5.47.08.02.52.8-2.82.8-2.8-2.82.12.5
Pavlov. Cond. lever-magazine prob. diff.5.57.07.5-2.3-2.72.7-2.72.72.7-2.6-2.7
Pavlov. Cond. response bias4.15.56.1-1.9-2.42.4-2.42.42.4-2.5-2.3
Time in closed arm before self-admin3.03.43.8-1.8-1.91.9-1.91.91.9-1.6-1.8
Time in closed arm after self-admin1.51.51.8-0.9-1.31.3-1.21.31.3-1.0-1.4
Time in open arm before self-admin5.25.66.32.32.4-2.42.5-2.4-2.42.22.3
Time in open arm after self-admin3.43.84.12.02.0-2.01.9-1.9-1.92.01.8
Bone: periosteal estimation0.10.31.00.60.4-0.20.3-0.1-0.31.00.6
Bone: periosteal perimeter0.10.20.90.60.3-0.00.3-0.0-0.11.00.3
Bone: post-yield work1.21.61.81.31.3-1.31.4-1.2-1.31.21.2
Progressive ratio test 1 active lever presses0.00.00.00.0-0.10.1-0.10.10.1-0.1-0.2
Progressive ratio test 1 breakpoint0.10.10.2-0.2-0.20.3-0.30.20.3-0.4-0.4
Progressive ratio test 1 inactive lever presses2.73.03.31.71.8-1.81.8-1.8-1.81.51.7
Progressive ratio test 2 active lever presses0.00.00.0-0.0-0.00.0-0.00.00.1-0.2-0.2
Progressive ratio test 2 breakpoint0.00.00.00.10.00.0-0.00.00.0-0.2-0.2
Progressive ratio test 2 inactive lever presses0.91.11.21.11.1-1.11.1-1.1-1.00.90.9
Incentive Sensitization - Responses0.00.00.0-0.0-0.10.1-0.10.10.10.0-0.2
Incentive Sensitization - Breakpoint0.00.00.00.10.1-0.00.0-0.0-0.00.1-0.1
Sum of active levers in priming session hrs 5-60.20.20.7-0.6-0.40.4-0.30.40.4-0.8-0.4
Progressive ratio0.40.50.70.80.6-0.70.7-0.6-0.70.50.7
Food seeking constrained by brief footshock1.72.02.61.11.5-1.41.4-1.4-1.41.61.6
Seeking ratio, punishment vs. effort0.10.10.1-0.00.3-0.30.2-0.3-0.30.30.3
Retroperitoneal fat weight0.20.70.9-0.7-0.80.9-0.90.90.90.0-1.0
Reaction time number correct3.14.55.52.12.3-2.32.1-2.3-2.21.61.9
Reaction time mean minus median0.20.20.4-0.3-0.40.5-0.60.60.50.3-0.3
Reaction time mean minus median AUC0.20.20.4-0.3-0.40.5-0.70.60.50.3-0.3
Reaction time num false alarms1.01.42.21.51.2-1.21.2-1.3-1.20.90.8
Reaction time num false alarms AUC1.52.13.31.81.5-1.51.5-1.5-1.41.31.1
Reaction time trials correct on left3.14.55.52.12.3-2.32.1-2.3-2.21.61.9
Reaction time trials on left3.14.45.42.12.3-2.32.1-2.3-2.21.61.9
Reaction time mean1.01.41.6-1.2-1.21.2-1.21.31.2-0.9-1.1
Reaction time mean AUC0.70.91.1-0.9-1.01.0-1.01.01.0-0.6-0.9
Median of all reaction times0.70.91.0-1.0-1.00.9-0.91.00.9-0.9-1.0
Reaction time omissions0.91.22.41.01.0-1.01.0-0.9-1.01.51.1
Reaction time false alarm rate0.10.20.60.80.3-0.30.4-0.4-0.30.50.2
Reaction time premature initiation rate0.81.11.70.81.1-1.11.3-1.1-1.00.71.1
Reaction time premature initiations2.53.54.61.72.0-2.02.1-2.0-2.01.31.8
Std. dev. reaction times0.40.60.9-0.6-0.80.9-0.91.00.90.0-0.6
Reaction time trials completed3.14.45.42.12.3-2.32.1-2.3-2.21.61.9
Reaction time trials AUC3.44.85.82.22.4-2.42.2-2.4-2.31.71.9
Run reversals in cocaine runway, females1.01.01.2-1.1-1.01.0-1.01.01.0-0.8-1.1
Run reversals in cocaine runway, males0.90.81.00.71.0-1.00.9-1.0-1.00.90.9
Latency to leave start box in cocaine runway0.10.10.3-0.1-0.20.2-0.10.10.2-0.5-0.3
Latency to leave start box in cocaine runway, F0.10.10.5-0.4-0.10.1-0.20.00.2-0.7-0.3
Latency to leave start box in cocaine runway, M0.10.10.1-0.0-0.30.3-0.10.30.3-0.1-0.3
Std. dev. time between licks in bursts0.91.11.5-0.9-1.11.0-1.01.11.0-1.2-0.9
Total sessions with >9 infusions0.10.10.8-0.2-0.20.1-0.20.10.2-0.9-0.2
Short access day 1 total inactive lever presses0.00.10.2-0.0-0.10.1-0.10.20.2-0.4-0.4
Short access day 10 total inactive lever presses0.40.50.80.70.7-0.60.7-0.6-0.60.90.6
Short access day 1 total infusions0.30.30.60.80.5-0.60.5-0.5-0.50.40.4
Short access day 10 total infusions0.30.30.6-0.3-0.60.6-0.60.60.6-0.4-0.8
Short access total infusions0.20.20.3-0.1-0.50.4-0.50.40.5-0.5-0.5
Short access day 1 locomotion0.60.71.1-0.5-0.80.7-0.90.70.8-1.0-1.0
Short access day 10 total locomotion0.70.71.6-0.7-0.80.8-0.90.80.8-1.3-0.9
Short access total locomotion0.10.10.5-0.1-0.20.2-0.40.20.2-0.7-0.3
One hour access (0.3 mA shock)0.10.10.30.50.3-0.30.4-0.3-0.3-0.10.2
Compulsive drug intake0.00.00.00.1-0.20.1-0.10.10.10.2-0.2
One hour access (shock baseline)0.00.10.3-0.0-0.10.1-0.10.10.1-0.6-0.1
Social response proportion0.40.40.60.70.7-0.70.7-0.7-0.60.50.5
Social responses0.00.00.1-0.2-0.20.2-0.10.20.2-0.3-0.2
Social time0.81.11.41.11.0-1.01.0-0.9-1.01.21.1
Soleus weight0.00.00.2-0.0-0.10.1-0.20.20.2-0.5-0.1
Bone: stiffness1.52.43.51.71.5-1.41.5-1.3-1.51.91.6
Tibialis anterior weight0.31.21.61.21.1-1.01.1-1.0-1.00.91.3
Time to tail flick, vehicle, before self-admin0.50.51.00.40.7-0.70.6-0.7-0.71.00.8
Time to tail flick, vehicle, after self-admin0.20.20.4-0.3-0.40.4-0.40.40.4-0.7-0.4
Time to tail flick, test, before self-admin0.10.10.2-0.10.3-0.30.4-0.3-0.3-0.10.3
Time to tail flick, test, after self-admin1.61.72.01.21.3-1.31.1-1.3-1.41.41.3
Delta time to tail flick, vehicle, before/after SA0.10.10.7-0.2-0.20.2-0.20.20.2-0.8-0.3
Delta time to tail flick, test, before/after SA1.00.91.71.30.8-0.90.7-0.8-0.91.20.9
Tibia length0.41.11.90.91.0-0.91.0-0.9-1.01.31.4
Ambulatory time before self-admin0.00.00.2-0.1-0.20.2-0.20.10.2-0.0-0.4
Ambulatory time after self-admin0.00.00.10.0-0.10.10.00.10.1-0.3-0.1
Bone: tissue strength0.10.10.50.30.3-0.20.4-0.2-0.20.70.3
Total heroin consumption1.01.21.70.71.1-1.11.2-1.1-1.10.91.3
Bone: trabecular number0.00.00.10.10.3-0.30.1-0.3-0.2-0.10.1
Bone: trabecular spacing0.10.10.2-0.0-0.40.4-0.20.40.3-0.0-0.2
Bone: trabecular thickness0.10.10.20.20.3-0.40.4-0.4-0.40.20.4
Bone: trabecular tissue density0.30.40.70.30.8-0.70.7-0.8-0.70.30.3
Water consumed over 24 hours3.34.04.42.01.9-2.02.1-2.0-2.01.92.1
Number of responses in last shaping day0.50.50.7-0.7-0.80.8-0.80.80.7-0.4-0.5