Cnr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	XM_006237984.4	0.07	0.06	2.8e-06	0.07	0.06	0.06	0.07	2.7e-07	5.3e-06	1.2e-06	7.5e-07
2	pVTA	gene expression	Cnr1	0.33	0.15	9.2e-08	0.18	0.18	0.17	0.17	3.6e-08	2.0e-08	6.1e-08	4.9e-08
3	IL	mRNA stability	Cnr1	0.24	0.17	4.7e-04	0.05	0.01	-0.01	0.02	2.3e-02	1.5e-01	1.0e+00	1.0e-01
4	OFC	alternative polyA	XM_017593151.2	0.38	0.2	1.1e-07	0.26	0.26	0.22	0.24	7.2e-07	9.2e-07	6.5e-06	1.7e-06
5	OFC	alternative polyA	XM_006237984.4	0.38	0.19	3.4e-08	0.23	0.25	0.22	0.25	2.6e-06	9.8e-07	6.0e-06	1.2e-06
6	Adipose	gene expression	Cnr1	0.1	0.17	5.9e-06	0.03	0.03	0.02	0.03	2.2e-04	1.9e-04	2.7e-03	3.4e-04
7	Eye	gene expression	Cnr1	0.84	0.1	3.2e-03	0.06	0.09	-0.01	0.04	4.9e-02	1.9e-02	5.2e-01	9.6e-02
8	Brain	gene expression	Cnr1	0.39	0.2	0.0e+00	0.19	0.19	0.19	0.19	8.1e-18	1.0e-17	4.8e-17	3.1e-17

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.5	0.8	1.5	1.2	1.2	1.2	-1.0	-0.7	0.7	0.2	0.2
Area under the delay curve	0.0	0.0	0.2	-0.1	-0.1	-0.2	0.0	0.1	-0.1	0.5	-0.2
BMI with tail	3.0	9.6	11.4	3.1	3.3	3.3	-3.4	-3.2	3.2	-2.3	2.8
BMI without tail	2.9	5.9	7.4	2.3	2.1	2.5	-2.6	-2.5	2.6	-2.1	2.7
Body weight	5.6	23.7	29.5	4.7	5.3	5.4	-5.3	-5.1	5.2	-2.8	4.6
Weight adjusted by age	1.9	2.2	4.1	2.0	1.9	1.2	-1.7	-1.5	1.4	0.1	0.9
Bone surface	1.2	2.2	4.2	1.8	2.1	1.7	-1.7	-1.4	1.3	-0.2	0.6
Bone volume	0.6	1.1	1.9	1.4	1.4	1.3	-1.2	-0.9	0.8	-0.4	0.3
Breakpoint value in progressive ratio session	0.3	0.3	1.4	0.1	-0.0	0.5	-0.2	-0.4	0.4	-1.2	0.9
Number of licking bursts	0.2	0.2	0.6	-0.6	-0.4	-0.3	0.2	0.6	-0.6	0.2	-0.7
Context. condit. distance diff. score	0.7	0.8	1.2	-0.9	-0.9	-0.9	0.9	1.0	-1.0	0.1	-1.1
Locomotion velocity, session 1	0.1	0.1	0.4	-0.6	-0.4	0.2	-0.1	0.2	-0.2	-0.1	-0.1
Locomotion distance, session 1	2.9	3.8	6.7	-2.5	-2.6	-1.9	2.0	2.0	-1.9	0.4	-1.3
Locomotion velocity, session 2	0.0	0.0	0.1	-0.0	-0.0	-0.1	0.1	0.0	0.0	0.4	-0.0
Locomotion distance, session 2	4.2	5.9	10.1	-3.2	-3.0	-2.4	2.5	2.5	-2.5	0.7	-1.8
Locomotion velocity, session 3	1.8	2.1	2.7	-1.4	-1.6	-1.5	1.6	1.5	-1.5	0.6	-1.4
Locomotion distance, session 3	2.9	3.2	3.8	-1.8	-1.9	-1.9	1.9	1.9	-1.9	0.9	-1.7
Stereotopy head waving bouts, day 3	0.6	0.8	1.1	1.1	1.1	0.9	-0.9	-0.9	0.9	-0.3	0.7
Stereotopy head waving duration, day 3	1.5	1.7	2.8	1.6	1.7	1.2	-1.4	-1.4	1.4	-0.2	1.1
Locomotion velocity, session 7	0.5	0.6	1.1	-1.0	-1.0	-0.9	0.9	0.7	-0.6	0.1	-0.1
Locomotion distance, session 7	2.0	2.6	4.2	-2.0	-1.8	-1.8	1.9	1.5	-1.5	0.8	-1.0
Stereotopy head waving bouts, day 7	0.4	0.4	0.5	0.6	0.7	0.7	-0.7	-0.7	0.7	-0.4	0.7
Stereotopy head waving duration, day 7	1.9	2.3	3.2	1.7	1.8	1.5	-1.7	-1.6	1.6	-0.6	1.3
Locomotion velocity, session 8	3.8	4.5	6.5	-2.5	-2.5	-2.2	2.3	2.2	-2.1	0.7	-1.8
Locomotion distance, session 8	5.5	8.1	11.2	-3.2	-3.3	-2.9	3.0	3.0	-3.0	0.9	-2.6
Degree of sensitization distance	0.3	0.3	0.8	0.2	0.5	0.5	-0.3	-0.6	0.7	-0.1	0.9
Degree of sensitization stereotypy	0.3	0.4	0.6	0.6	0.7	0.8	-0.7	-0.6	0.6	-0.4	0.5
Conditioned locomotion	0.1	0.1	0.2	0.4	0.2	0.2	-0.1	-0.1	0.1	0.5	0.1
Cocaine response after cond. corrected	0.3	0.3	0.7	0.3	0.8	0.1	-0.2	-0.5	0.6	0.8	0.6
Cocaine response after cond. not corrected	0.3	0.3	2.2	-0.2	0.3	-0.3	0.1	0.1	0.0	1.5	-0.1
Cocaine response before conditioning	0.1	0.2	0.6	-0.1	-0.2	-0.1	0.0	0.5	-0.5	0.6	-0.8
Saline control response	0.8	1.1	1.8	1.2	1.4	1.2	-1.2	-1.0	1.0	0.3	0.6
Bone: connectivity density	0.8	1.3	2.8	1.3	1.7	1.3	-1.2	-1.0	1.0	0.7	0.4
Bone: cortical apparent density	0.1	0.2	0.4	-0.4	-0.6	-0.6	0.2	0.4	-0.4	-0.1	-0.3
Bone: cortical area	3.4	5.1	7.4	2.7	2.7	2.5	-2.4	-2.3	2.3	-1.1	1.6
Bone: cortical porosity	0.1	0.1	0.3	0.6	0.3	0.2	-0.1	-0.1	0.1	0.2	0.0
Bone: cortical porosity	0.5	0.6	1.2	1.1	0.9	0.8	-0.7	-0.7	0.7	-0.0	0.6
Bone: cortical thickness	0.9	1.5	2.3	1.5	1.4	1.4	-1.4	-1.1	1.1	-0.9	0.5
Bone: cortical thickness	0.3	0.3	0.7	0.7	0.8	0.8	-0.7	-0.4	0.3	0.2	-0.2
Bone: cortical tissue density	0.1	0.2	0.4	-0.4	-0.6	-0.6	0.2	0.4	-0.4	-0.0	-0.3
Condit. Reinf. active minus inactive responses	2.5	2.8	3.9	-2.0	-1.8	-1.7	1.8	1.7	-1.7	1.1	-1.3
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.8	-1.1	-0.8	-1.0	0.9	1.2	-1.2	1.7	-1.3
Condit. Reinf. active responses	1.1	1.4	2.1	-1.4	-1.4	-1.2	1.3	1.2	-1.2	0.3	-1.0
Condit. Reinf. inactive responses	0.4	0.4	1.6	-0.5	-0.9	-0.3	0.5	0.3	-0.3	-1.3	-0.1
Incentive salience index mean	0.8	0.9	1.5	-1.2	-1.1	-0.9	1.0	1.0	-0.9	0.6	-0.7
Condit. Reinf. lever presses	0.0	0.1	0.2	-0.4	-0.2	0.1	0.0	-0.0	0.1	-0.3	0.4
Condit. Reinf. active minus inactive responses	0.4	0.5	1.8	0.6	1.0	0.6	-0.6	-0.3	0.3	1.3	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.1	0.3	0.4	-0.3	-0.1	0.1	0.5	-0.1
Condit. Reinf. active responses	0.6	0.8	2.4	0.9	1.3	0.8	-0.8	-0.5	0.5	1.6	-0.2
Condit. Reinf. inactive responses	0.3	0.4	0.9	0.9	0.9	0.5	-0.5	-0.3	0.3	1.0	-0.2
Condit. Reinf. lever presses	1.1	1.5	3.1	1.4	1.8	1.4	-1.3	-1.1	1.1	0.7	0.6
Condit. Reinf. lever reinforcers received	0.8	1.1	2.4	1.2	1.5	1.0	-1.0	-0.8	0.8	1.4	0.1
Conditioned reinforcement - actives	0.3	0.3	1.8	0.4	0.5	0.2	0.1	-0.1	0.3	1.4	0.4
Conditioned reinforcement - inactives	0.5	0.6	2.3	0.9	-0.2	0.4	-0.2	-0.4	0.5	-1.5	1.0
Conditioned locomotion	0.6	0.7	1.5	0.1	0.7	1.1	-0.7	-0.8	0.9	-0.8	1.2
Patch foraging indifference point 0 sec	0.3	0.4	1.0	1.0	0.8	0.7	-0.7	-0.6	0.6	-0.0	0.4
Patch foraging indifference point AUC	1.4	1.6	2.8	1.2	1.2	1.7	-1.3	-1.3	1.2	-0.9	1.3
Delay disc. indifference point, 0s delay	1.6	1.7	6.2	-1.0	-0.6	-1.3	1.0	1.1	-1.0	2.5	-1.1
Delay disc. indifference point, 16s delay	0.2	0.3	0.7	0.6	0.3	0.6	-0.5	-0.4	0.3	-0.8	0.2
Delay disc. indifference point, 2s delay	0.4	0.4	2.7	0.0	0.3	-0.1	-0.1	0.2	-0.2	1.7	-0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.2	0.2	-0.2	0.4	-0.3
Delay disc. indifference point, 4s delay	0.5	0.5	1.1	-1.0	-0.8	-0.8	0.8	0.6	-0.5	0.7	-0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	0.1	-0.0	-0.2	0.0	0.1	-0.1	0.6	-0.3
Indifference point function ln k	0.2	0.3	0.6	-0.5	-0.5	-0.8	0.5	0.6	-0.5	0.2	-0.8
Indifference point function log k	0.2	0.3	0.6	-0.5	-0.5	-0.8	0.5	0.6	-0.5	0.2	-0.8
Patch foraging total patch changes 0 sec	0.2	0.3	0.8	0.9	0.7	0.6	-0.6	-0.5	0.4	0.3	0.2
Patch foraging total patch changes 12 sec	2.2	2.9	4.2	1.7	1.4	2.0	-1.8	-1.7	1.7	-1.3	1.9
Patch foraging total patch changes 18 sec	0.3	0.3	0.8	0.9	0.6	0.6	-0.6	-0.4	0.3	0.8	0.2
Patch foraging total patch changes 24 sec	1.2	1.4	2.7	1.0	1.3	1.6	-1.1	-1.2	1.3	0.3	1.2
Patch foraging total patch changes 6 sec	1.3	1.9	2.7	1.6	1.0	1.6	-1.5	-1.2	1.1	-1.7	1.3
Patch foraging time to switch 0 sec	1.8	2.8	4.2	-1.9	-1.9	-2.1	2.0	1.6	-1.6	1.1	-1.1
Patch foraging water rate 0 sec	1.6	2.6	3.4	1.8	1.5	1.8	-1.8	-1.6	1.5	-1.2	1.5
Patch foraging water rate 12 sec	0.1	0.2	1.2	0.4	0.5	-0.2	0.2	-0.1	0.1	1.1	-0.4
Patch foraging water rate 18 sec	0.2	0.3	1.9	0.0	0.3	0.0	-0.0	0.1	-0.1	1.4	-0.2
Patch foraging water rate 24 sec	0.0	0.0	0.1	0.1	-0.1	0.1	0.0	-0.1	0.1	-0.3	0.1
Patch foraging water rate 6 sec	0.2	0.3	0.9	0.6	0.9	0.7	-0.5	-0.5	0.6	0.3	0.1
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	0.5	0.1	-0.1	-0.2	-0.3	0.3	-0.3	0.5
Distance traveled before self-admin	0.2	0.3	1.3	0.1	0.5	0.2	-0.2	-0.3	0.3	1.2	0.4
Distance traveled after self-admin	0.0	0.0	0.0	0.2	-0.1	-0.0	-0.0	0.0	-0.1	-0.1	0.0
Extensor digitorum longus weight	4.1	16.1	18.5	4.2	4.2	4.2	-4.3	-4.2	4.2	-2.6	3.8
Bone: elastic displacement	0.3	0.4	1.8	-0.3	-0.7	0.2	0.0	-0.1	0.0	-1.3	0.7
Bone: elastic work	3.5	4.5	8.6	1.5	1.2	2.2	-1.9	-2.0	2.0	-2.9	2.6
Bone: endosteal estimation	3.7	8.1	11.5	3.4	3.4	2.8	-2.9	-3.1	3.1	-0.5	2.6
Bone: endosteal perimeter	2.8	5.8	7.3	2.7	2.7	2.5	-2.3	-2.6	2.6	-1.0	2.4
Epididymis fat weight	0.0	0.1	0.3	-0.3	-0.0	-0.0	0.1	0.2	-0.2	-0.4	-0.6
Delta time in closed arm before/after self-admin	1.3	1.3	4.5	-0.7	-0.1	-0.7	0.7	1.0	-0.9	2.1	-1.5
Delta time in open arm before/after self-admin	0.7	0.6	2.3	0.1	-0.2	0.7	-0.2	-0.6	0.6	-1.5	1.2
Diff in mean of infusions in LGA sessions	0.5	0.5	3.4	-0.2	-0.7	0.0	0.2	0.0	-0.1	-1.8	0.5
Delay discount exponential model param	0.0	0.0	0.1	0.2	0.2	0.2	-0.1	-0.1	0.1	-0.3	0.2
Extinction: sum of active levers before priming	0.4	0.4	0.8	-0.8	-0.9	-0.5	0.9	0.6	-0.6	0.4	-0.0
Active lever presses in extinction session 6	0.5	0.5	1.1	-0.8	-1.1	-0.6	0.7	0.6	-0.7	-0.9	-0.2
Bone: final force	2.4	3.9	5.9	2.2	2.4	2.3	-2.1	-2.0	2.0	-0.4	1.4
Bone: final moment	3.4	5.5	7.3	2.6	2.7	2.7	-2.5	-2.4	2.5	-1.0	1.9
Food consumed during 24 hour testing period	1.6	1.9	2.5	1.6	1.5	1.3	-1.3	-1.4	1.4	-0.8	1.5
Glucose	0.0	0.1	0.2	-0.5	0.0	-0.0	-0.0	0.1	0.0	0.4	0.1
Heart weight	0.7	1.0	1.3	0.8	1.0	1.0	-1.1	-1.1	1.1	-0.9	1.0
Delay discount hyperbolic model param	0.0	0.0	0.1	0.2	0.2	0.2	-0.1	-0.1	0.2	-0.3	0.2
Intermittent access intake day 1-15 change	4.0	4.0	5.5	-1.3	-1.9	-2.3	2.0	2.1	-2.0	1.9	-2.0
Intermittent access intake escalation	2.9	2.8	4.1	-0.9	-1.7	-2.0	1.7	1.9	-1.8	1.6	-1.6
Intermittent access intake escalation 2	1.1	1.0	1.6	0.1	-1.0	-1.2	0.9	1.2	-1.2	0.9	-1.3
Intermitt. access day 1 inactive lever presses	1.9	2.0	3.0	-1.6	-1.0	-1.2	1.5	1.4	-1.3	1.7	-1.5
Intermitt. access day 15 inactive lever presses	1.9	2.1	2.8	-1.2	-1.6	-1.6	1.7	1.5	-1.5	-0.5	-1.5
Intermitt. access escalation Index	0.1	0.1	0.1	-0.3	-0.2	-0.3	0.2	-0.0	0.1	-0.4	0.3
Intermittent access day 1 total infusions	2.8	3.3	4.4	1.8	1.5	1.8	-1.7	-1.8	1.8	-2.1	2.0
Intermittent access day 15 total infusions	0.3	0.3	1.4	1.2	0.2	0.2	-0.3	-0.3	0.4	-0.6	0.7
Intermittent access terminal intake (last 3 days)	0.1	0.2	1.0	1.0	-0.0	0.0	-0.1	-0.0	0.0	-0.4	0.2
Intermittent access total infusions	2.1	2.3	3.5	1.9	1.2	1.5	-1.4	-1.4	1.4	-1.4	1.8
Intermittent access day 1 locomotion	1.8	1.8	8.1	0.6	0.5	1.2	-1.0	-1.0	1.0	-2.8	1.3
Intermittent access day 15 total locomotion	0.8	0.9	3.9	0.7	0.2	0.6	-0.7	-0.7	0.7	-2.0	0.9
Intermittent access total locomotion	1.1	1.3	2.9	1.1	0.7	1.1	-1.0	-1.0	1.0	-1.7	1.2
Intermittent access standard deviation	1.5	1.6	2.3	-1.0	-1.2	-1.5	1.3	1.4	-1.3	1.1	-1.1
Left kidney weight	2.0	5.6	7.4	2.2	2.7	2.4	-2.3	-2.6	2.7	-1.0	2.6
Right kidney weight	2.4	6.8	8.2	2.5	2.7	2.9	-2.6	-2.7	2.8	-1.9	2.8
Cocaine induced anxiety	1.1	1.3	6.7	-0.7	0.1	-0.8	0.7	0.7	-0.6	2.6	-1.0
Post-drug Anxiety	0.1	0.1	0.4	0.6	0.3	0.2	-0.3	-0.2	0.2	0.4	0.4
Baseline Anxiety	1.2	1.2	5.7	1.3	-0.1	0.7	-0.7	-0.6	0.5	-2.4	1.0
Tail length	0.8	2.3	3.4	1.4	1.4	1.7	-1.5	-1.6	1.6	-1.1	1.8
Length with tail	2.1	7.6	10.1	2.6	3.1	3.2	-2.8	-2.9	3.0	-1.2	2.8
Length without tail	1.3	2.9	5.7	1.6	2.4	2.0	-1.8	-1.7	1.8	0.1	1.1
Times rat made contact with spout	0.0	0.0	0.1	0.2	0.2	0.0	-0.2	-0.0	-0.0	-0.1	-0.1
Lifetime Intake	2.1	2.3	3.8	1.9	1.2	1.4	-1.3	-1.4	1.4	-1.6	1.8
Liver weight, left	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.3	0.3	-0.3	0.1	-0.3
Liver weight, right	0.1	0.2	0.4	-0.5	-0.3	-0.4	0.5	0.5	-0.6	0.4	-0.6
Locomotor activity	0.5	0.9	2.0	-1.4	-1.0	-0.5	0.8	0.9	-0.9	0.3	-1.1
Locomotor testing distance	0.2	0.4	0.9	-0.9	-0.7	-0.4	0.5	0.6	-0.6	-0.1	-0.7
Locomotor testing rearing	0.6	0.9	2.1	-0.8	-0.9	-0.6	0.5	1.1	-1.2	0.5	-1.5
Locomotion in novel chamber	2.0	2.4	3.9	2.0	1.3	1.4	-1.6	-1.5	1.4	-1.7	1.4
Locomotion in novel chamber post-restriction	2.0	2.5	17.1	0.3	-0.9	0.3	-0.4	-0.4	0.2	-4.1	1.1
Fecal boli incidents, locomotor time 1	1.1	1.3	7.2	-0.6	0.2	-0.9	0.6	0.6	-0.5	2.7	-0.9
Change in fecal boli incidents, locomotor task	0.4	0.4	2.8	0.4	-0.4	0.0	-0.3	-0.3	0.1	-1.7	0.4
Time >=10cm from walls, locomotor time 1	0.5	0.5	3.4	-0.4	0.4	-0.6	0.1	0.2	-0.1	1.8	-0.4
Bouts of movement, locomotor time 1	0.4	0.4	1.0	-1.0	-0.8	-0.3	0.9	0.6	-0.5	0.3	0.0
Total resting periods, locomotor time 1	0.3	0.4	0.8	-0.9	-0.6	-0.3	0.8	0.5	-0.4	0.9	0.0
Rest time, locomotor task time 1	0.4	0.4	0.8	-0.8	-0.9	-0.8	0.8	0.6	-0.5	-0.3	0.3
Distance moved, locomotor task time 1	0.3	0.4	1.1	0.5	0.9	0.4	-0.5	-0.4	0.4	1.0	-0.3
Vertical activity count, locomotor time 1	0.2	0.2	0.9	-0.0	0.4	-0.0	-0.1	0.1	-0.1	1.0	-0.7
Time >=10cm from walls, locomotor time 2	1.3	1.3	5.3	0.9	1.5	0.4	-0.9	-0.7	0.8	2.3	0.5
Bouts of movement, locomotor time 2	1.7	1.8	9.1	0.4	-0.0	1.5	-0.7	-0.8	0.6	-3.0	1.1
Total resting periods, locomotor time 2	1.9	2.0	11.1	0.4	-0.1	1.5	-0.7	-0.7	0.6	-3.3	1.1
Rest time, locomotor task time 2	0.7	0.8	5.6	-0.1	-0.6	0.2	0.0	-0.0	-0.0	-2.4	0.5
Distance moved, locomotor task time 2	0.4	0.4	2.8	-0.1	0.1	-0.5	0.3	0.2	-0.2	1.7	-0.4
Vertical activity count, locomotor time 2	0.6	0.7	5.0	0.0	0.7	-0.1	0.0	-0.2	0.3	2.2	0.1
Light reinforcement 1	1.8	3.3	5.2	1.5	1.4	1.8	-1.7	-1.9	1.9	-1.8	2.3
Light reinforcement 2	1.3	1.7	2.7	1.5	1.6	1.2	-1.4	-1.4	1.4	-0.6	1.0
Bone: marrow area	3.8	8.3	11.8	3.4	3.4	2.8	-2.9	-3.1	3.1	-0.5	2.6
Bone: maximum diameter	3.3	6.1	8.4	2.9	2.9	2.7	-2.6	-2.6	2.6	-1.0	2.0
Bone: maximum force	3.3	5.6	8.2	2.7	2.9	2.7	-2.5	-2.4	2.4	-0.9	1.8
Bone: maximum moment	3.9	6.8	8.8	2.9	3.0	2.9	-2.8	-2.7	2.7	-1.3	2.1
Mean time between licks in bursts	0.5	0.8	1.4	0.8	0.6	0.9	-0.9	-0.8	0.8	-0.8	1.2
Mean num. licks in bursts	0.2	0.3	0.5	0.6	0.4	0.3	-0.3	-0.5	0.6	-0.4	0.7
Cd content in liver	0.4	0.4	0.6	0.8	0.8	0.7	-0.7	-0.6	0.6	0.1	0.4
Co content in liver	0.4	0.4	0.9	0.9	0.7	0.7	-0.8	-0.6	0.6	0.2	0.5
Cu content in liver	0.6	0.7	1.5	-0.7	-0.6	-0.9	0.9	0.8	-0.7	1.2	-0.7
Fe content in liver	0.1	0.1	0.2	0.3	0.3	0.3	-0.3	-0.4	0.4	-0.0	0.5
K content in liver	2.4	2.4	3.4	-1.4	-1.5	-1.8	1.8	1.6	-1.6	1.3	-1.4
Mg content in liver	0.6	0.6	2.2	-0.7	-0.4	-0.7	0.8	0.6	-0.6	1.5	-0.6
Mn content in liver	0.0	0.0	0.1	0.2	0.3	-0.1	0.0	-0.1	0.2	-0.1	0.0
Na content in liver	3.0	3.1	3.4	-1.7	-1.5	-1.8	1.8	1.8	-1.8	1.7	-1.8
Rb content in liver	0.9	1.1	2.7	-0.8	-0.5	-0.9	0.8	1.0	-1.0	1.6	-1.3
Se content in liver	4.8	5.9	9.2	-2.0	-1.7	-2.5	2.5	2.4	-2.4	3.0	-2.7
Sr content in liver	4.7	4.3	5.1	-2.1	-2.3	-2.1	2.2	2.2	-2.2	1.1	-2.1
Zn content in liver	0.3	0.3	0.6	0.7	0.7	0.5	-0.5	-0.5	0.5	0.8	0.4
Bone: minimum diameter	1.5	2.8	4.1	1.9	2.0	1.8	-1.7	-1.8	1.8	-0.7	1.3
Time in familiar zone, hab. session 1	1.3	1.2	2.1	0.9	0.9	1.0	-0.9	-1.2	1.2	-1.0	1.5
Time in novel zone, hab. session 1	4.8	4.7	6.2	-1.9	-1.9	-2.3	2.0	2.3	-2.3	2.1	-2.5
Total zone transitions, hab. session 1	8.8	12.3	20.2	-4.5	-4.2	-3.5	3.8	3.6	-3.5	1.0	-2.8
Total locomotion distance, hab. session 1	5.8	8.3	12.0	-3.5	-3.2	-2.8	3.1	3.0	-3.0	1.0	-2.6
Locomotion velocity, hab. session 1	4.0	5.7	9.1	-3.0	-2.7	-2.2	2.6	2.5	-2.5	0.7	-2.1
Time in familiar zone, hab. session 2	0.4	0.4	1.9	0.2	-0.2	0.2	-0.2	-0.4	0.4	-1.4	0.8
Time in novel zone, hab. session 2	0.2	0.2	1.1	-0.1	0.2	-0.1	0.0	0.2	-0.2	1.0	-0.5
Total zone transitions, hab. session 2	3.6	4.7	9.1	-3.0	-2.9	-2.1	2.3	2.1	-2.1	-0.1	-1.3
Total locomotion distance, hab. session 2	1.0	1.3	2.2	-1.5	-1.5	-1.1	1.2	1.2	-1.1	-0.3	-0.8
Locomotion velocity, hab. session 2	0.8	1.1	1.9	-1.4	-1.3	-1.0	1.1	1.1	-1.1	-0.1	-0.8
Novel to familiar place preference ratio	0.1	0.1	0.5	-0.4	0.1	-0.2	0.3	0.3	-0.2	0.7	-0.5
Novelty place preference	0.5	0.5	1.2	-0.7	-0.3	-0.5	0.6	0.7	-0.6	1.1	-0.9
Time in novel zone, NPP test	0.7	0.7	1.4	-0.9	-0.4	-0.6	0.7	0.8	-0.8	1.2	-1.1
Total zone transitions, NPP test	3.1	4.4	8.2	-2.9	-2.3	-2.0	2.1	2.2	-2.1	0.9	-1.9
Total locomotion distance, NPP test	0.6	0.8	1.3	-1.1	-0.8	-0.8	0.9	0.9	-0.9	0.3	-0.9
Locomotion velocity, NPP test	0.3	0.4	0.9	-0.9	-0.7	-0.6	0.8	0.7	-0.6	0.1	-0.6
Intraocular pressure	6.6	9.2	22.1	2.5	1.5	2.8	-2.7	-2.8	2.7	-4.7	3.5
Delta distance traveled before/after self-admin	0.3	0.3	1.7	0.1	-0.6	-0.1	0.1	0.3	-0.4	-1.3	-0.4
Delta ambulatory time before/after self-admin	0.9	1.0	6.6	0.2	-0.9	-0.1	0.0	0.3	-0.5	-2.6	-0.4
Parametrial fat weight	0.7	1.3	2.2	-1.3	-1.5	-1.2	1.2	1.2	-1.2	-0.3	-0.8
Pavlov. Cond. lever latency	0.5	0.6	1.9	0.0	-0.1	-0.4	0.6	0.7	-0.8	1.3	-1.4
Pavlov. Cond. magazine entry latency	0.5	0.7	2.8	-0.3	-0.5	0.3	-0.3	-0.4	0.4	-1.7	1.4
Pavlov. Cond. change in total contacts	0.3	0.3	1.0	-1.0	-0.7	-0.6	0.6	0.5	-0.4	0.3	-0.1
Pavlov. Cond. index score	0.6	0.8	2.9	-0.2	-0.3	0.4	-0.5	-0.6	0.6	-1.7	1.5
Pavlov. Cond. latency score	0.9	1.1	3.4	0.0	-0.1	0.6	-0.7	-0.8	0.9	-1.8	1.7
Pavlov. Cond. lever contacts	0.9	1.0	3.0	0.1	0.1	0.7	-0.8	-0.9	1.0	-1.5	1.7
Pavlov. Cond. magazine entry number	0.8	1.0	3.6	-0.1	0.1	-0.6	0.7	0.8	-0.8	1.9	-1.7
Pavlov. Cond. intertrial magazine entries	2.6	3.1	4.5	-1.3	-1.3	-1.8	1.8	1.8	-1.8	2.0	-2.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.9	-0.4	-0.4	0.2	-0.3	-0.4	0.5	-1.4	1.4
Pavlov. Cond. response bias	0.6	0.7	2.3	-0.2	-0.2	0.4	-0.6	-0.6	0.7	-1.5	1.5
Pavlov. Cond. lever latency	0.3	0.4	1.1	-0.6	-1.0	-0.6	0.5	0.5	-0.5	-1.0	-0.1
Pavlov. Cond. magazine entry latency	0.7	0.8	1.0	-0.8	-0.8	-1.0	0.9	0.9	-0.9	0.8	-0.9
Pavlov. Cond. change in total contacts	0.2	0.3	0.8	0.8	0.9	0.4	-0.4	-0.4	0.4	0.8	0.3
Pavlov. Cond. index score	0.1	0.2	1.1	-0.0	0.3	-0.1	0.1	0.2	-0.1	1.1	-0.3
Pavlov. Cond. latency score	0.2	0.2	0.9	0.4	0.7	0.3	-0.3	-0.3	0.3	1.0	0.1
Pavlov. Cond. lever contacts	0.3	0.3	1.2	0.5	0.9	0.5	-0.4	-0.3	0.3	1.1	-0.1
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	0.7	0.4	0.8	-0.6	-0.7	0.7	-0.9	0.7
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.0	-0.1	0.4	-0.2	0.0	-0.0	0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	1.2	-0.1	0.2	-0.2	0.2	0.3	-0.2	1.1	-0.4
Pavlov. Cond. response bias	0.2	0.3	1.4	-0.2	0.2	-0.2	0.2	0.3	-0.3	1.2	-0.6
Time in closed arm before self-admin	4.8	5.4	8.5	2.9	2.7	2.0	-2.5	-2.5	2.4	-1.2	2.1
Time in closed arm after self-admin	1.6	1.6	3.2	1.8	1.6	1.3	-1.5	-1.2	1.1	-0.6	0.4
Time in open arm before self-admin	1.6	1.8	5.3	-1.1	-0.5	-1.3	0.9	1.2	-1.1	2.3	-1.5
Time in open arm after self-admin	0.5	0.5	1.2	-1.1	-1.1	-0.6	0.8	0.6	-0.5	-0.5	0.2
Bone: periosteal estimation	4.6	9.5	13.7	3.7	3.7	3.2	-3.2	-3.2	3.2	-1.0	2.5
Bone: periosteal perimeter	5.7	9.5	12.3	3.4	3.5	3.3	-3.1	-3.2	3.3	-1.5	2.8
Bone: post-yield work	0.7	1.0	1.6	1.1	1.3	1.0	-1.0	-1.1	1.1	-0.2	0.7
Progressive ratio test 1 active lever presses	0.2	0.2	0.5	0.7	0.2	0.3	-0.2	-0.4	0.4	-0.3	0.6
Progressive ratio test 1 breakpoint	0.0	0.0	0.2	0.4	0.1	0.0	-0.0	-0.1	0.2	0.1	0.3
Progressive ratio test 1 inactive lever presses	0.7	0.8	1.7	-0.3	-1.3	-1.0	1.2	1.0	-0.9	-0.3	-0.5
Progressive ratio test 2 active lever presses	1.4	1.5	2.5	1.5	0.9	1.3	-1.0	-1.1	1.2	-1.0	1.6
Progressive ratio test 2 breakpoint	1.2	1.4	2.3	1.5	1.0	1.3	-1.0	-1.1	1.2	-0.6	1.5
Progressive ratio test 2 inactive lever presses	0.8	0.9	6.4	0.6	-0.4	-0.0	0.1	-0.1	0.2	-2.5	0.5
Incentive Sensitization - Responses	1.3	1.3	2.6	1.3	0.6	1.3	-0.9	-1.1	1.0	-1.1	1.6
Incentive Sensitization - Breakpoint	1.8	1.8	3.5	1.5	0.9	1.6	-1.1	-1.3	1.3	-1.1	1.9
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.6	0.3	0.3	0.4	-0.4	-0.4	0.4	-0.2	0.8
Progressive ratio	1.7	2.0	7.6	0.4	0.4	1.3	-1.1	-1.1	1.1	-2.8	1.7
Food seeking constrained by brief footshock	6.4	7.8	13.7	2.9	3.7	2.9	-2.8	-2.7	2.7	2.2	2.1
Seeking ratio, punishment vs. effort	1.6	1.9	10.8	1.2	1.5	0.3	-0.5	-0.4	0.4	3.3	-0.2
Retroperitoneal fat weight	0.8	2.8	4.2	-1.8	-1.4	-1.5	1.7	1.7	-1.7	1.2	-2.0
Reaction time number correct	0.4	0.5	1.3	0.7	1.1	0.5	-0.5	-0.8	0.8	0.7	0.5
Reaction time mean minus median	1.0	1.3	2.2	-1.2	-1.3	-1.5	1.3	1.2	-1.1	0.4	-0.9
Reaction time mean minus median AUC	1.1	1.4	2.0	-1.3	-1.1	-1.4	1.4	1.2	-1.1	0.9	-0.9
Reaction time num false alarms	1.2	1.7	5.4	1.0	0.9	1.3	-1.2	-1.0	1.0	-2.3	0.9
Reaction time num false alarms AUC	1.4	2.0	5.3	1.3	1.0	1.5	-1.4	-1.2	1.1	-2.3	1.0
Reaction time trials correct on left	0.4	0.5	1.3	0.7	1.1	0.5	-0.5	-0.8	0.8	0.7	0.5
Reaction time trials on left	0.5	0.7	1.5	0.8	1.2	0.6	-0.6	-0.9	0.9	0.7	0.5
Reaction time mean	0.2	0.2	0.7	0.3	0.5	0.2	-0.3	-0.5	0.6	-0.2	0.8
Reaction time mean AUC	0.1	0.1	0.4	0.2	0.4	0.1	-0.2	-0.4	0.4	0.1	0.6
Median of all reaction times	0.7	0.9	1.7	0.8	1.1	0.9	-0.8	-1.0	1.1	-0.4	1.3
Reaction time omissions	0.8	1.0	2.3	1.5	1.4	0.9	-1.0	-0.9	0.9	-0.2	0.6
Reaction time false alarm rate	0.7	1.0	6.5	0.3	-0.1	0.8	-0.6	-0.4	0.3	-2.6	0.5
Reaction time premature initiation rate	0.2	0.2	0.6	0.3	0.5	0.2	-0.3	-0.4	0.5	0.8	0.4
Reaction time premature initiations	0.6	0.9	1.6	0.9	1.3	0.6	-0.8	-1.0	1.1	1.0	0.9
Std. dev. reaction times	0.5	0.8	1.1	-0.9	-0.7	-1.1	1.0	0.8	-0.7	1.0	-0.6
Reaction time trials completed	0.5	0.7	1.5	0.8	1.2	0.6	-0.6	-0.9	0.9	0.7	0.5
Reaction time trials AUC	0.4	0.6	1.4	0.8	1.2	0.5	-0.6	-0.8	0.9	0.7	0.5
Run reversals in cocaine runway, females	0.6	0.6	0.8	0.9	0.8	0.9	-0.7	-0.7	0.7	-0.3	0.9
Run reversals in cocaine runway, males	0.7	0.7	1.5	-0.7	-0.9	-1.2	0.9	0.9	-0.8	0.5	-0.7
Latency to leave start box in cocaine runway	1.0	1.1	1.6	1.2	1.1	1.2	-1.1	-1.1	1.1	-0.2	1.0
Latency to leave start box in cocaine runway, F	0.4	0.4	0.7	0.6	0.8	0.8	-0.6	-0.7	0.7	0.2	0.4
Latency to leave start box in cocaine runway, M	0.5	0.5	0.9	1.0	0.7	0.7	-0.8	-0.6	0.5	0.0	0.7
Std. dev. time between licks in bursts	0.4	0.4	0.7	0.8	0.8	0.7	-0.7	-0.7	0.7	-0.1	0.5
Total sessions with >9 infusions	0.5	0.6	2.3	-0.3	-0.2	0.4	-0.2	-0.4	0.5	-1.5	1.2
Short access day 1 total inactive lever presses	0.4	0.4	2.1	0.1	-0.7	-0.4	0.7	0.1	-0.1	-1.5	0.3
Short access day 10 total inactive lever presses	1.1	1.2	2.0	-1.2	-1.0	-1.0	1.2	1.2	-1.1	0.4	-1.4
Short access day 1 total infusions	0.5	0.5	1.4	-0.2	-1.0	-0.4	0.7	0.6	-0.6	-1.2	-0.4
Short access day 10 total infusions	0.8	0.8	2.2	1.5	0.8	0.8	-0.7	-0.7	0.8	-0.8	1.0
Short access total infusions	0.9	1.0	3.5	1.2	0.3	0.7	-0.6	-0.7	0.7	-1.9	1.0
Short access day 1 locomotion	0.3	0.3	0.9	-0.7	-0.5	-0.3	0.4	0.3	-0.2	-0.9	-0.1
Short access day 10 total locomotion	1.1	1.2	6.1	0.7	0.5	1.0	-0.9	-0.7	0.7	-2.5	0.7
Short access total locomotion	0.5	0.5	3.7	0.0	-0.2	0.4	-0.3	-0.2	0.2	-1.9	0.3
One hour access (0.3 mA shock)	0.4	0.5	1.3	1.2	0.7	0.6	-0.4	-0.6	0.7	0.2	0.8
Compulsive drug intake	0.2	0.2	0.8	-0.9	-0.3	-0.4	0.3	0.3	-0.2	-0.4	-0.3
One hour access (shock baseline)	0.8	0.9	2.3	1.5	1.1	0.8	-0.7	-0.7	0.8	0.9	0.9
Social response proportion	1.8	2.0	2.8	-1.2	-1.5	-1.7	1.5	1.5	-1.5	0.2	-1.6
Social responses	0.3	0.4	1.5	-0.2	0.1	-0.3	0.2	0.6	-0.6	1.1	-1.2
Social time	0.3	0.4	1.0	-0.4	-0.2	-0.7	0.5	0.5	-0.4	1.0	-0.8
Soleus weight	1.5	4.4	6.1	2.5	2.2	2.2	-2.3	-2.2	2.2	-1.1	1.9
Bone: stiffness	0.3	0.5	1.4	0.9	1.2	0.5	-0.6	-0.4	0.5	0.9	-0.3
Tibialis anterior weight	6.6	22.4	26.0	5.1	4.9	5.1	-5.1	-4.9	4.8	-3.5	4.4
Time to tail flick, vehicle, before self-admin	0.6	0.6	3.9	0.8	-0.1	0.3	-0.4	-0.4	0.2	-2.0	0.4
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.8	0.0	0.3	-0.3	0.1	0.1	-0.0	0.9	-0.2
Time to tail flick, test, before self-admin	5.8	5.7	12.5	2.4	1.5	2.5	-2.3	-2.2	2.0	-3.5	2.2
Time to tail flick, test, after self-admin	0.4	0.4	1.2	0.6	0.4	0.5	-0.4	-0.6	0.6	-0.2	1.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	3.7	-0.2	0.3	-0.6	0.3	0.3	-0.3	1.9	-0.7
Delta time to tail flick, test, before/after SA	1.9	1.7	2.7	-1.4	-1.1	-1.6	1.4	1.2	-1.1	1.4	-1.0
Tibia length	1.4	4.0	4.8	2.0	1.9	2.2	-1.9	-2.1	2.1	-1.6	2.1
Ambulatory time before self-admin	0.1	0.2	1.0	-0.3	-0.1	-0.2	0.2	0.1	-0.1	1.0	0.3
Ambulatory time after self-admin	0.3	0.3	1.5	0.5	-0.1	0.4	-0.4	-0.3	0.2	-1.2	0.5
Bone: tissue strength	0.6	0.6	0.8	-0.9	-0.9	-0.9	0.8	0.7	-0.7	0.1	-0.7
Total heroin consumption	0.1	0.2	0.7	-0.2	0.1	0.3	0.0	-0.4	0.5	0.2	0.8
Bone: trabecular number	0.2	0.3	0.8	0.7	0.9	0.6	-0.6	-0.3	0.2	0.6	-0.3
Bone: trabecular spacing	0.6	0.7	1.1	0.8	0.6	0.8	-0.8	-0.9	0.9	-0.9	1.0
Bone: trabecular thickness	0.1	0.1	0.2	0.5	0.4	0.3	-0.2	-0.1	0.1	0.1	-0.2
Bone: trabecular tissue density	4.5	6.3	9.7	-2.3	-2.4	-2.3	2.4	2.8	-2.8	1.7	-3.1
Water consumed over 24 hours	1.5	1.8	2.5	1.6	1.5	1.4	-1.5	-1.4	1.3	-0.7	1.2
Number of responses in last shaping day	0.1	0.1	0.5	-0.2	0.5	0.0	0.2	0.1	-0.2	0.4	-0.7