Hub : Genes

Clic2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Clic2 0.23 0.09 3.7e-14 0.06 0.18 0.14 0.17 6.5e-06 2.7e-14 1.0e-11 5.8e-14
2 BLA gene expression Clic2 0.15 0.08 8.3e-06 0.05 0.08 0.05 0.07 8.1e-04 3.8e-05 8.8e-04 1.7e-04
3 IL gene expression Clic2 0.25 0.12 1.9e-03 0 0.04 0.02 0.03 2.7e-01 3.2e-02 9.1e-02 7.1e-02
4 PL gene expression Clic2 0.18 0.07 0.0e+00 0.11 0.18 0.18 0.18 3.9e-12 1.0e-19 7.1e-19 4.8e-19
5 NAcc gene expression Clic2 0.07 0.04 1.5e-09 0.01 0.06 0.05 0.04 1.7e-02 4.2e-09 3.5e-08 2.6e-07
6 NAcc intron excision ratio chr20_143441_143993 0.05 0.03 6.1e-03 0.01 0.01 0.01 0.01 1.1e-02 3.2e-02 4.1e-02 7.6e-03
7 LHb gene expression Clic2 0.51 0.14 4.4e-08 0.15 0.24 0.16 0.2 2.2e-04 2.1e-06 1.1e-04 2.2e-05
8 Liver mRNA stability Clic2 0.49 0.16 0.0e+00 0.41 0.42 0.44 0.44 8.6e-49 1.8e-50 5.0e-54 8.6e-54
9 OFC gene expression Clic2 0.21 0.11 1.7e-03 0.01 0.13 0.06 0.07 1.8e-01 4.8e-04 1.9e-02 1.0e-02
10 Brain gene expression Clic2 0.27 0.09 0.0e+00 0.22 0.27 0.27 0.28 3.9e-20 6.1e-25 4.1e-25 9.0e-26
11 Adipose mRNA stability Clic2 0.52 0.09 0.0e+00 0.58 0.59 0.6 0.6 2.5e-78 1.1e-81 8.4e-83 8.2e-83
12 Brain mRNA stability Clic2 0.02 0.01 3.5e-03 0.03 0.02 0.03 0.02 1.1e-03 1.0e-02 1.8e-03 3.4e-03
13 Liver gene expression Clic2 0.29 0.11 0.0e+00 0.27 0.27 0.27 0.27 5.5e-30 3.0e-30 1.2e-29 2.0e-30

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.40.72.21.11.11.51.01.3-0.90.20.30.8-0.20.70.5-0.0
Area under the delay curve0.30.32.10.1-0.2-0.70.0-0.61.40.0-0.4-0.70.2-0.2-0.5-0.1
BMI with tail0.51.85.90.40.30.00.0-0.2-0.8-0.61.9-1.1-1.12.42.1-2.3
BMI without tail1.03.18.3-0.5-0.6-1.2-0.9-1.21.0-1.62.3-1.9-1.82.72.2-2.9
Body weight4.218.224.0-3.7-4.0-4.6-4.2-4.63.6-4.44.6-4.9-4.34.23.9-4.4
Weight adjusted by age1.72.55.4-1.5-1.7-1.9-1.7-1.82.3-1.71.4-1.6-1.11.01.6-0.7
Bone surface1.22.13.4-1.4-1.4-1.3-1.4-1.31.8-1.81.6-1.3-1.61.41.5-1.0
Bone volume0.81.42.8-0.6-0.6-0.5-0.7-0.51.2-1.51.7-0.9-1.51.71.6-1.2
Breakpoint value in progressive ratio session1.92.34.31.31.31.21.41.2-2.11.9-1.91.31.7-1.5-1.61.1
Number of licking bursts0.20.20.8-0.1-0.0-0.3-0.0-0.20.50.3-0.90.20.5-0.9-0.80.4
Context. condit. distance diff. score0.40.41.5-1.0-0.80.1-0.6-0.0-0.5-0.2-0.30.5-0.2-1.0-0.81.2
Locomotion velocity, session 10.20.20.9-0.4-0.4-0.4-0.3-0.20.90.0-0.40.10.4-0.7-0.40.7
Locomotion distance, session 11.31.62.31.21.21.21.31.2-0.91.4-1.51.11.4-1.3-1.31.2
Locomotion velocity, session 20.91.03.10.60.5-0.00.60.1-0.21.3-1.80.51.4-1.6-1.30.9
Locomotion distance, session 20.91.22.50.70.60.70.90.7-0.61.2-1.60.91.3-1.6-1.41.5
Locomotion velocity, session 30.91.12.01.31.41.01.21.1-0.81.3-0.91.11.3-0.4-0.60.1
Locomotion distance, session 32.32.53.11.41.51.61.61.6-1.11.7-1.71.71.7-1.5-1.81.5
Stereotopy head waving bouts, day 30.60.81.7-1.3-1.2-1.3-1.2-1.21.0-0.70.2-0.7-0.4-0.10.0-0.3
Stereotopy head waving duration, day 30.70.81.5-1.2-1.1-1.2-1.2-1.11.0-0.80.4-0.7-0.50.30.4-0.6
Locomotion velocity, session 70.91.02.20.70.71.10.91.1-0.20.9-1.01.20.7-1.1-1.21.5
Locomotion distance, session 75.16.47.72.52.52.72.72.8-0.82.6-2.72.72.4-2.5-2.62.7
Stereotopy head waving bouts, day 70.60.74.5-0.4-0.5-1.1-0.4-0.82.10.1-0.8-0.40.6-0.8-0.80.3
Stereotopy head waving duration, day 71.11.34.1-1.2-1.3-1.8-1.3-1.62.0-0.80.2-1.2-0.40.10.1-0.5
Locomotion velocity, session 81.61.94.0-1.8-1.8-1.9-1.5-1.72.0-0.5-1.0-0.80.1-1.6-1.00.8
Locomotion distance, session 80.81.23.9-0.1-0.10.60.40.5-0.50.8-1.40.90.8-1.9-1.72.0
Degree of sensitization distance0.10.10.8-0.3-0.3-0.2-0.2-0.10.9-0.2-0.20.1-0.2-0.4-0.20.5
Degree of sensitization stereotypy0.50.51.90.1-0.1-0.50.1-0.31.40.5-1.10.00.9-1.1-1.00.7
Conditioned locomotion2.02.34.6-1.0-1.1-1.4-1.3-1.50.2-1.41.8-1.8-1.71.91.6-2.1
Cocaine response after cond. corrected0.20.21.70.30.40.30.30.2-1.30.4-0.10.20.30.10.2-0.2
Cocaine response after cond. not corrected0.80.91.7-1.2-1.1-1.3-1.2-1.30.5-1.00.8-1.0-0.70.60.8-0.8
Cocaine response before conditioning5.56.615.2-2.8-2.8-3.1-2.8-2.93.9-2.82.0-2.5-2.11.41.4-1.5
Saline control response0.91.23.5-0.1-0.2-0.5-0.5-0.51.0-1.21.6-0.8-1.11.91.6-1.7
Bone: connectivity density0.20.31.10.40.41.00.40.8-0.8-0.20.40.6-0.30.40.40.2
Bone: cortical apparent density0.60.82.40.80.80.70.50.6-0.6-0.21.1-0.1-0.61.51.3-1.3
Bone: cortical area0.50.82.2-0.9-1.1-1.2-0.9-1.11.5-0.90.5-1.0-0.60.20.4-0.2
Bone: cortical porosity3.13.48.11.41.40.61.51.00.82.0-2.81.52.3-2.6-2.51.8
Bone: cortical porosity1.92.15.40.60.6-0.00.70.31.51.2-2.30.91.7-2.3-2.21.7
Bone: cortical thickness0.20.31.31.10.80.50.90.5-0.00.40.1-0.20.10.50.3-0.6
Bone: cortical thickness0.80.92.11.41.31.11.10.9-1.20.40.40.2-0.11.20.7-1.2
Bone: cortical tissue density0.50.72.20.70.70.60.40.5-0.6-0.21.1-0.1-0.61.51.3-1.3
Condit. Reinf. active minus inactive responses0.00.00.1-0.1-0.00.0-0.00.00.00.1-0.10.20.1-0.3-0.10.4
Condit. Reinf. active-inactive response ratio0.00.00.20.10.1-0.1-0.0-0.10.10.00.2-0.1-0.00.40.3-0.4
Condit. Reinf. active responses0.10.11.0-0.2-0.20.1-0.1-0.0-1.0-0.00.30.0-0.30.10.20.1
Condit. Reinf. inactive responses0.70.94.80.70.81.30.91.0-2.20.8-0.30.80.3-0.3-0.30.6
Incentive salience index mean0.30.41.1-1.1-1.0-0.6-0.8-0.7-0.7-0.0-0.2-0.3-0.2-0.8-0.40.7
Condit. Reinf. lever presses0.81.14.5-1.4-1.3-0.6-1.0-0.8-2.10.0-0.4-0.3-0.2-1.1-0.81.1
Condit. Reinf. active minus inactive responses1.31.72.4-1.4-1.4-1.6-1.5-1.51.5-1.41.2-1.3-1.01.10.9-1.0
Condit. Reinf. active-inactive response ratio2.63.13.8-1.8-1.8-1.9-1.9-2.01.6-1.81.8-1.9-1.61.61.5-1.6
Condit. Reinf. active responses0.10.10.3-0.5-0.4-0.4-0.5-0.30.4-0.50.3-0.0-0.10.20.1-0.1
Condit. Reinf. inactive responses0.10.20.70.20.30.60.30.6-0.80.0-0.10.70.2-0.1-0.10.3
Condit. Reinf. lever presses0.10.20.7-0.20.10.3-0.00.4-0.0-0.0-0.40.80.3-0.5-0.70.8
Condit. Reinf. lever reinforcers received0.10.10.3-0.5-0.4-0.3-0.5-0.20.2-0.50.20.1-0.00.1-0.00.1
Conditioned reinforcement - actives0.20.30.80.60.50.30.50.30.9-0.20.6-0.2-0.60.80.6-0.7
Conditioned reinforcement - inactives0.10.20.50.60.60.40.60.50.70.3-0.10.30.00.0-0.2-0.0
Conditioned locomotion0.71.01.9-0.6-0.7-0.6-0.7-0.70.7-1.11.3-1.0-1.41.11.1-1.1
Patch foraging indifference point 0 sec0.50.82.11.21.11.01.21.11.40.4-0.50.90.5-0.3-0.70.6
Patch foraging indifference point AUC0.30.43.4-0.4-0.5-0.8-0.4-0.61.9-0.2-0.0-0.30.2-0.20.10.3
Delay disc. indifference point, 0s delay0.60.61.6-0.8-1.0-1.2-0.7-1.20.4-0.60.3-1.2-0.60.2-0.0-0.4
Delay disc. indifference point, 16s delay1.71.93.81.91.61.01.71.10.61.6-1.60.91.8-1.0-1.50.7
Delay disc. indifference point, 2s delay0.60.71.6-0.8-0.9-1.3-0.8-1.21.2-0.60.3-1.1-0.60.3-0.0-0.7
Delay disc. indifference point, 24s delay0.40.42.60.70.4-0.00.50.11.60.3-0.80.10.6-0.4-0.60.2
Delay disc. indifference point, 4s delay2.22.34.0-1.3-1.5-2.0-1.5-1.91.7-1.51.2-1.9-1.31.11.0-1.4
Delay disc. indifference point, 8s delay0.30.31.20.50.30.00.50.11.10.4-0.70.10.5-0.6-0.80.6
Indifference point function ln k0.30.52.1-0.3-0.2-0.1-0.0-0.00.20.3-1.20.30.4-1.4-1.21.0
Indifference point function log k0.30.52.1-0.3-0.2-0.1-0.0-0.00.20.3-1.20.30.4-1.4-1.21.0
Patch foraging total patch changes 0 sec0.61.12.51.41.21.01.31.21.60.6-0.71.00.7-0.5-0.80.8
Patch foraging total patch changes 12 sec0.70.92.11.41.30.91.21.11.30.7-0.50.90.9-0.0-0.20.4
Patch foraging total patch changes 18 sec0.50.71.71.21.21.31.11.3-0.50.50.31.00.40.70.00.0
Patch foraging total patch changes 24 sec2.23.88.72.92.72.52.72.50.21.8-1.11.91.6-0.4-1.11.0
Patch foraging total patch changes 6 sec0.60.92.41.51.41.01.31.21.20.40.10.70.40.60.2-0.2
Patch foraging time to switch 0 sec0.71.57.70.91.01.00.60.8-2.80.11.20.0-0.51.70.9-1.5
Patch foraging water rate 0 sec0.20.45.10.1-0.1-0.10.00.02.3-0.2-0.10.00.0-0.30.10.7
Patch foraging water rate 12 sec0.00.10.20.10.10.30.20.2-0.00.3-0.20.20.1-0.4-0.20.4
Patch foraging water rate 18 sec0.20.40.8-0.7-0.7-0.6-0.7-0.60.4-0.80.4-0.6-0.90.30.5-0.5
Patch foraging water rate 24 sec0.10.20.5-0.2-0.4-0.4-0.3-0.40.6-0.40.3-0.6-0.60.30.7-0.4
Patch foraging water rate 6 sec0.50.71.31.01.01.21.01.1-0.40.9-0.90.90.6-0.6-0.50.7
Seeking ratio, delayed vs. immediate footshock0.10.10.7-0.4-0.2-0.6-0.3-0.40.90.00.0-0.10.1-0.4-0.10.2
Distance traveled before self-admin1.31.64.0-2.0-1.8-1.3-1.8-1.4-0.1-1.40.9-1.1-1.40.30.7-0.3
Distance traveled after self-admin1.21.53.7-1.9-1.7-1.7-1.8-1.60.3-1.30.6-1.1-0.90.10.7-0.5
Extensor digitorum longus weight0.41.55.8-1.5-1.5-1.3-1.3-1.22.4-1.40.8-1.0-1.00.00.40.3
Bone: elastic displacement0.20.20.80.90.80.50.70.50.10.6-0.20.30.40.1-0.2-0.2
Bone: elastic work0.10.10.40.30.1-0.30.0-0.30.40.00.2-0.40.10.50.3-0.6
Bone: endosteal estimation4.810.517.7-4.2-4.1-4.2-4.1-4.03.6-3.52.2-3.1-2.51.21.8-1.5
Bone: endosteal perimeter2.45.011.7-3.4-3.2-2.8-3.1-2.72.3-2.41.2-1.7-1.60.10.70.1
Epididymis fat weight1.55.110.73.33.12.92.62.5-2.31.01.50.9-0.32.91.4-2.3
Delta time in closed arm before/after self-admin0.40.40.7-0.3-0.4-0.5-0.4-0.50.8-0.60.8-0.6-0.70.70.5-0.6
Delta time in open arm before/after self-admin0.60.61.1-1.1-1.0-0.8-1.0-0.80.7-0.90.6-0.5-0.70.20.5-0.2
Diff in mean of infusions in LGA sessions2.32.76.01.41.41.81.61.6-2.51.9-1.71.51.5-1.4-1.61.3
Delay discount exponential model param0.30.32.2-0.10.20.80.00.6-1.50.00.30.7-0.20.10.50.2
Extinction: sum of active levers before priming2.52.75.51.41.51.61.51.5-2.31.9-1.81.61.7-1.5-1.71.1
Active lever presses in extinction session 61.51.54.01.51.51.51.41.3-2.01.4-0.81.00.8-0.2-0.7-0.2
Bone: final force0.71.22.1-0.4-0.6-0.9-0.7-1.01.2-1.01.2-1.3-1.01.41.4-1.5
Bone: final moment0.91.52.7-0.6-0.8-1.0-0.8-1.01.6-1.21.4-1.3-1.21.51.5-1.4
Food consumed during 24 hour testing period1.72.33.0-1.6-1.6-1.7-1.7-1.70.6-1.61.6-1.6-1.61.41.1-1.5
Glucose1.22.05.2-2.3-2.0-1.6-1.9-1.42.1-1.40.4-0.5-0.7-0.6-0.00.8
Heart weight1.82.79.0-1.0-1.3-1.8-1.3-1.63.0-1.71.5-1.8-1.41.41.5-1.4
Delay discount hyperbolic model param0.30.32.0-0.20.10.7-0.00.6-1.4-0.10.40.6-0.20.20.50.2
Intermittent access intake day 1-15 change0.10.10.3-0.3-0.2-0.2-0.3-0.2-0.5-0.40.4-0.3-0.30.40.4-0.5
Intermittent access intake escalation0.10.20.7-0.0-0.0-0.2-0.2-0.2-0.5-0.30.5-0.3-0.20.70.5-0.8
Intermittent access intake escalation 20.40.51.3-1.1-1.0-0.8-1.0-0.80.6-0.80.2-0.5-0.4-0.10.3-0.1
Intermitt. access day 1 inactive lever presses0.20.61.9-1.4-1.2-1.1-1.1-1.1-0.1-0.60.1-0.7-0.5-0.3-0.50.1
Intermitt. access day 15 inactive lever presses0.40.81.5-1.2-1.2-1.2-1.0-1.21.2-0.90.3-0.9-0.80.0-0.3-0.2
Intermitt. access escalation Index1.82.55.91.11.01.31.21.2-2.41.9-1.51.41.9-1.7-1.41.8
Intermittent access day 1 total infusions0.50.81.51.21.21.21.21.1-0.61.0-0.50.80.5-0.3-0.50.2
Intermittent access day 15 total infusions0.40.51.90.40.40.20.20.1-0.7-0.31.0-0.4-0.71.30.8-1.4
Intermittent access terminal intake (last 3 days)0.30.41.50.40.40.20.30.20.2-0.30.8-0.3-0.61.10.7-1.2
Intermittent access total infusions0.20.31.10.30.30.20.20.10.1-0.30.7-0.2-0.70.90.5-1.1
Intermittent access day 1 locomotion0.30.30.9-0.3-0.3-0.3-0.3-0.4-0.6-0.40.8-0.5-0.80.70.5-0.9
Intermittent access day 15 total locomotion1.62.94.4-1.3-1.4-1.6-1.5-1.70.5-1.72.1-1.9-1.81.91.9-2.1
Intermittent access total locomotion2.12.54.2-1.3-1.4-1.6-1.4-1.60.4-1.61.8-1.9-1.81.71.5-2.1
Intermittent access standard deviation0.40.92.6-0.2-0.2-0.4-0.3-0.41.6-1.01.1-0.7-1.11.31.2-1.2
Left kidney weight2.210.413.2-3.1-3.2-3.6-3.3-3.53.3-3.43.2-3.6-3.32.62.7-2.9
Right kidney weight4.319.723.6-4.0-4.2-4.5-4.4-4.54.1-4.84.9-4.8-4.74.24.1-4.3
Cocaine induced anxiety0.50.72.2-1.5-1.3-0.9-1.2-0.90.0-1.00.6-0.6-1.00.00.20.0
Post-drug Anxiety0.30.41.1-1.1-0.8-0.6-0.9-0.6-0.7-0.60.3-0.2-0.4-0.00.40.1
Baseline Anxiety1.31.63.11.51.51.51.41.4-1.81.3-0.81.31.3-0.4-0.20.6
Tail length3.212.422.4-4.1-4.1-4.6-4.1-4.34.7-3.62.4-3.6-3.01.51.6-1.9
Length with tail6.528.442.9-6.1-6.2-6.6-6.1-6.36.4-5.74.3-5.5-4.92.93.1-3.1
Length without tail6.721.726.7-4.8-5.0-5.1-5.0-5.23.7-5.04.9-5.2-4.83.83.9-3.7
Times rat made contact with spout3.13.65.72.32.42.22.32.2-1.42.0-1.72.01.9-0.9-1.60.9
Lifetime Intake0.20.21.00.30.20.00.10.00.4-0.30.7-0.3-0.70.80.4-1.0
Liver weight, left2.84.610.6-3.3-3.0-2.9-3.0-2.81.6-2.21.0-1.9-1.70.10.8-0.5
Liver weight, right4.57.912.7-3.6-3.5-3.5-3.5-3.42.3-3.02.1-2.9-2.61.31.7-1.7
Locomotor activity2.94.57.6-2.8-2.6-2.4-2.6-2.32.6-2.61.7-1.7-2.10.91.3-0.7
Locomotor testing distance1.01.84.0-1.7-1.6-1.4-1.5-1.22.0-1.71.1-0.9-1.50.50.8-0.3
Locomotor testing rearing1.02.03.4-1.8-1.6-1.4-1.7-1.31.5-1.81.5-1.0-1.50.91.2-0.6
Locomotion in novel chamber0.30.41.20.30.30.00.40.11.10.6-0.90.20.6-0.8-0.90.6
Locomotion in novel chamber post-restriction0.50.91.1-0.7-0.8-0.9-0.9-0.91.0-1.00.9-1.0-1.10.90.9-1.1
Fecal boli incidents, locomotor time 10.10.20.5-0.10.00.3-0.20.20.0-0.40.70.2-0.50.70.7-0.3
Change in fecal boli incidents, locomotor task1.51.52.6-1.0-1.0-1.1-1.1-1.2-0.2-1.11.4-1.4-1.41.41.2-1.6
Time >=10cm from walls, locomotor time 13.23.44.6-2.1-2.0-1.8-2.1-1.90.5-2.02.1-1.9-2.01.71.6-1.5
Bouts of movement, locomotor time 10.40.51.8-0.1-0.10.20.10.30.90.2-0.70.60.6-1.0-1.01.4
Total resting periods, locomotor time 10.10.20.5-0.5-0.4-0.2-0.3-0.10.7-0.2-0.10.10.1-0.4-0.50.6
Rest time, locomotor task time 11.82.23.3-1.8-1.6-1.5-1.8-1.50.5-1.71.7-1.3-1.51.41.3-1.2
Distance moved, locomotor task time 10.91.42.41.20.90.81.20.80.91.3-1.50.81.2-1.5-1.41.3
Vertical activity count, locomotor time 10.30.61.30.90.70.60.90.60.50.9-1.20.50.7-1.0-1.00.8
Time >=10cm from walls, locomotor time 21.72.63.6-1.6-1.6-1.5-1.7-1.61.5-1.91.8-1.6-1.81.51.2-1.3
Bouts of movement, locomotor time 20.50.81.9-1.4-1.2-1.2-1.2-1.11.3-0.8-0.1-0.5-0.3-0.5-0.10.1
Total resting periods, locomotor time 20.61.02.7-1.6-1.4-1.4-1.4-1.21.3-0.9-0.2-0.5-0.3-0.7-0.20.3
Rest time, locomotor task time 21.92.46.2-2.5-2.2-1.7-2.2-1.7-0.1-1.61.4-1.3-1.40.50.8-0.3
Distance moved, locomotor task time 20.30.41.31.20.80.50.90.50.90.20.2-0.1-0.00.60.3-0.4
Vertical activity count, locomotor time 20.10.10.40.60.50.40.50.30.00.2-0.10.0-0.10.20.2-0.3
Light reinforcement 10.10.10.50.70.50.50.60.4-0.30.4-0.00.00.20.2-0.2-0.1
Light reinforcement 22.33.55.1-1.5-1.8-1.9-1.7-1.91.5-2.02.2-2.3-2.02.01.6-1.9
Bone: marrow area4.810.517.4-4.2-4.0-4.2-4.1-4.03.5-3.52.2-3.1-2.61.31.9-1.5
Bone: maximum diameter1.32.55.7-2.4-2.3-2.1-2.0-1.92.0-1.3-0.1-1.0-0.5-1.0-0.40.8
Bone: maximum force1.01.92.7-0.9-1.1-1.3-1.1-1.31.6-1.41.4-1.6-1.31.51.6-1.4
Bone: maximum moment1.42.54.5-1.1-1.3-1.4-1.4-1.52.1-1.71.7-1.6-1.61.61.7-1.4
Mean time between licks in bursts0.82.05.0-2.2-2.0-1.8-2.0-1.81.2-1.40.6-1.1-1.0-0.10.3-0.0
Mean num. licks in bursts0.40.61.61.11.11.31.01.1-1.10.40.20.60.10.70.3-0.2
Cd content in liver0.60.62.1-0.1-0.2-0.0-0.3-0.20.5-0.81.2-0.6-1.01.41.0-1.1
Co content in liver0.30.30.91.00.70.50.70.40.30.20.2-0.10.20.80.4-0.8
Cu content in liver3.23.86.72.62.52.62.52.5-1.42.0-1.12.11.7-0.6-1.01.1
Fe content in liver0.91.02.7-0.2-0.2-0.4-0.5-0.5-0.4-0.81.5-0.9-1.21.71.4-1.6
K content in liver2.82.74.11.51.51.51.71.4-1.21.9-2.01.51.8-1.7-2.01.5
Mg content in liver0.50.51.4-0.00.10.30.20.2-0.50.6-1.20.60.8-1.1-1.11.1
Mn content in liver0.70.72.7-1.7-1.3-0.9-1.3-0.9-0.2-0.6-0.2-0.1-0.2-0.7-0.30.8
Na content in liver2.93.15.61.91.71.31.91.5-0.12.0-2.41.62.2-1.9-1.91.6
Rb content in liver0.30.30.90.70.71.00.80.9-0.40.3-0.10.70.10.1-0.20.3
Se content in liver1.21.43.8-1.2-1.1-1.3-0.9-1.01.2-0.0-1.4-0.10.7-2.0-1.61.5
Sr content in liver2.11.92.5-1.3-1.3-1.2-1.4-1.3-0.1-1.41.6-1.4-1.51.61.4-1.5
Zn content in liver0.00.00.2-0.0-0.10.10.00.10.5-0.10.20.1-0.0-0.00.10.4
Bone: minimum diameter2.34.18.6-2.9-2.8-2.6-2.7-2.51.6-2.21.3-1.9-1.70.41.0-0.5
Time in familiar zone, hab. session 13.93.86.82.52.62.62.42.5-2.11.9-1.12.11.5-0.3-0.90.6
Time in novel zone, hab. session 16.46.49.3-3.0-3.1-2.7-2.9-2.72.8-2.92.4-2.4-2.61.41.9-1.1
Total zone transitions, hab. session 10.40.51.10.50.50.80.70.7-0.30.6-1.00.70.6-0.9-0.81.0
Total locomotion distance, hab. session 10.50.71.00.60.60.80.80.7-0.80.9-1.00.70.7-1.0-1.01.0
Locomotion velocity, hab. session 11.11.52.51.11.01.11.21.0-1.11.4-1.61.01.2-1.3-1.41.1
Time in familiar zone, hab. session 20.50.52.80.70.81.00.70.9-1.70.40.20.60.10.4-0.0-0.1
Time in novel zone, hab. session 20.80.84.0-0.8-0.8-1.1-0.9-0.92.0-0.90.6-0.8-0.60.50.7-0.4
Total zone transitions, hab. session 20.20.20.50.30.30.40.50.3-0.50.5-0.70.20.4-0.6-0.70.5
Total locomotion distance, hab. session 20.30.41.90.30.30.70.50.5-1.40.5-0.60.40.3-0.5-0.60.6
Locomotion velocity, hab. session 20.70.92.50.50.60.90.80.7-1.60.9-1.10.70.7-1.0-1.11.0
Novel to familiar place preference ratio0.10.10.80.40.30.20.30.30.90.1-0.20.20.2-0.20.10.3
Novelty place preference0.10.11.30.0-0.1-0.2-0.0-0.11.2-0.20.1-0.1-0.1-0.00.30.1
Time in novel zone, NPP test0.30.32.1-0.3-0.4-0.6-0.4-0.51.4-0.50.4-0.5-0.40.20.6-0.2
Total zone transitions, NPP test0.10.20.90.20.20.50.30.50.10.3-0.50.40.2-0.6-0.50.9
Total locomotion distance, NPP test0.10.20.60.40.40.80.50.6-0.70.20.00.3-0.10.00.00.4
Locomotion velocity, NPP test0.71.01.91.01.01.41.11.2-1.30.9-0.71.00.6-0.6-0.71.0
Intraocular pressure0.10.10.4-0.10.00.3-0.00.2-0.1-0.30.40.1-0.50.30.6-0.1
Delta distance traveled before/after self-admin0.20.21.5-0.0-0.0-0.7-0.2-0.41.2-0.20.0-0.30.20.20.4-0.6
Delta ambulatory time before/after self-admin0.10.11.0-0.1-0.1-0.6-0.2-0.41.0-0.0-0.2-0.20.3-0.1-0.1-0.3
Parametrial fat weight1.53.56.0-1.4-1.4-1.4-1.6-1.50.6-1.92.5-1.9-2.12.42.3-2.2
Pavlov. Cond. lever latency1.41.84.51.51.51.61.21.4-1.20.01.20.5-0.52.11.4-1.6
Pavlov. Cond. magazine entry latency0.70.93.0-0.5-0.3-0.3-0.2-0.1-1.00.7-1.30.61.0-1.7-1.51.4
Pavlov. Cond. change in total contacts0.91.02.5-1.2-1.3-1.6-1.1-1.41.5-0.5-0.0-1.1-0.2-0.5-0.40.2
Pavlov. Cond. index score1.11.44.6-1.2-1.0-1.1-0.8-0.9-0.20.4-1.40.10.9-2.1-1.61.6
Pavlov. Cond. latency score1.31.65.6-1.2-1.1-1.2-0.8-1.00.10.4-1.60.00.9-2.4-1.81.7
Pavlov. Cond. lever contacts1.21.42.8-1.6-1.7-1.7-1.3-1.50.9-0.3-0.7-0.80.1-1.6-1.01.1
Pavlov. Cond. magazine entry number0.60.72.00.40.10.10.20.01.4-0.61.0-0.7-0.91.31.2-1.1
Pavlov. Cond. intertrial magazine entries0.10.20.50.30.30.50.30.4-0.2-0.20.60.0-0.50.70.4-0.5
Pavlov. Cond. lever-magazine prob. diff.1.11.45.0-0.9-0.8-0.8-0.6-0.7-0.40.6-1.60.31.0-2.2-1.81.7
Pavlov. Cond. response bias0.60.71.6-1.2-1.0-1.0-0.9-0.9-0.5-0.0-0.6-0.10.3-1.3-0.90.9
Pavlov. Cond. lever latency0.10.10.4-0.1-0.3-0.5-0.2-0.50.10.1-0.1-0.6-0.1-0.10.1-0.2
Pavlov. Cond. magazine entry latency0.10.20.5-0.5-0.5-0.5-0.4-0.50.7-0.0-0.2-0.20.0-0.4-0.50.0
Pavlov. Cond. change in total contacts0.10.10.7-0.2-0.2-0.3-0.3-0.30.8-0.40.3-0.2-0.20.40.1-0.3
Pavlov. Cond. index score0.10.10.6-0.4-0.3-0.3-0.3-0.20.8-0.2-0.00.10.0-0.1-0.30.1
Pavlov. Cond. latency score0.00.10.4-0.2-0.1-0.1-0.1-0.00.6-0.0-0.20.20.2-0.2-0.50.1
Pavlov. Cond. lever contacts0.00.00.1-0.10.00.2-0.10.20.1-0.30.30.3-0.20.30.1-0.0
Pavlov. Cond. magazine entry number0.10.21.00.30.30.40.30.4-1.00.2-0.30.50.3-0.2-0.00.3
Pavlov. Cond. intertrial magazine entries0.50.72.5-0.2-0.1-0.10.0-0.0-0.60.6-1.40.50.9-1.6-1.31.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.7-0.4-0.3-0.2-0.3-0.20.8-0.2-0.10.10.0-0.2-0.40.2
Pavlov. Cond. response bias0.10.10.3-0.5-0.3-0.2-0.4-0.10.5-0.50.4-0.0-0.30.30.2-0.1
Time in closed arm before self-admin0.20.20.50.60.60.50.60.5-0.70.5-0.30.30.2-0.0-0.0-0.1
Time in closed arm after self-admin0.20.20.80.90.70.30.80.3-0.50.60.0-0.20.10.30.0-0.5
Time in open arm before self-admin0.30.30.60.30.40.30.40.4-0.10.4-0.70.60.6-0.6-0.80.7
Time in open arm after self-admin0.20.20.5-0.7-0.4-0.3-0.6-0.20.3-0.3-0.10.40.2-0.4-0.30.7
Bone: periosteal estimation2.96.010.2-3.0-3.0-3.2-3.0-3.03.2-2.61.6-2.4-1.80.81.3-1.0
Bone: periosteal perimeter1.83.16.0-2.5-2.4-2.3-2.2-2.22.3-1.80.8-1.5-1.2-0.00.5-0.1
Bone: post-yield work2.23.37.3-2.7-2.5-2.0-2.4-1.91.8-2.21.3-1.3-1.70.41.0-0.0
Progressive ratio test 1 active lever presses0.30.31.00.80.80.60.70.6-1.00.60.00.20.20.30.0-0.5
Progressive ratio test 1 breakpoint0.20.30.80.70.70.60.60.5-0.90.50.10.20.10.30.1-0.6
Progressive ratio test 1 inactive lever presses0.40.61.51.21.11.21.11.0-0.70.60.20.40.10.60.3-0.3
Progressive ratio test 2 active lever presses0.60.71.51.21.21.01.00.9-1.20.8-0.10.60.50.3-0.1-0.4
Progressive ratio test 2 breakpoint0.60.71.61.31.21.01.11.0-1.20.8-0.10.50.50.4-0.1-0.5
Progressive ratio test 2 inactive lever presses0.00.00.10.1-0.0-0.10.1-0.10.2-0.00.0-0.3-0.20.1-0.2-0.2
Incentive Sensitization - Responses1.11.52.21.41.51.31.41.3-1.21.4-1.31.21.3-0.8-0.90.6
Incentive Sensitization - Breakpoint1.01.42.11.41.41.31.41.3-1.31.3-1.11.11.1-0.6-0.90.5
Sum of active levers in priming session hrs 5-60.10.10.2-0.10.10.1-0.10.1-0.30.1-0.40.40.3-0.3-0.40.1
Progressive ratio1.42.14.2-0.9-1.0-1.5-1.3-1.50.8-1.31.7-1.7-1.41.81.6-2.1
Food seeking constrained by brief footshock0.00.10.20.30.30.30.20.30.4-0.00.10.3-0.00.00.20.1
Seeking ratio, punishment vs. effort1.52.24.31.01.11.51.31.6-0.31.3-1.61.81.4-1.8-1.52.1
Retroperitoneal fat weight0.62.64.8-1.0-1.1-1.2-1.2-1.21.6-1.72.2-1.6-1.82.11.6-1.8
Reaction time number correct0.30.72.40.40.40.30.20.2-0.0-0.51.0-0.3-0.71.61.4-1.5
Reaction time mean minus median2.05.011.8-3.4-3.3-2.8-3.1-2.80.9-2.31.4-2.1-1.90.40.9-0.5
Reaction time mean minus median AUC1.33.37.9-2.8-2.7-2.2-2.5-2.30.9-1.91.1-1.7-1.40.20.8-0.2
Reaction time num false alarms2.23.16.91.51.40.91.61.10.81.9-2.61.42.1-2.4-2.21.9
Reaction time num false alarms AUC2.23.48.21.31.10.61.40.91.21.8-2.91.32.2-2.7-2.52.1
Reaction time trials correct on left0.30.72.40.40.40.30.20.2-0.0-0.51.0-0.3-0.71.61.4-1.5
Reaction time trials on left0.40.72.50.30.30.20.10.10.0-0.61.0-0.4-0.81.61.4-1.5
Reaction time mean2.03.29.5-3.1-2.9-2.1-2.6-2.20.4-1.80.8-1.4-1.4-0.30.20.3
Reaction time mean AUC2.13.49.5-3.1-2.9-2.2-2.7-2.30.7-1.80.9-1.5-1.4-0.20.30.2
Median of all reaction times1.21.75.6-2.4-2.2-1.4-1.9-1.50.1-1.20.4-0.9-0.9-0.5-0.10.5
Reaction time omissions1.82.76.9-2.6-2.5-2.0-2.4-2.10.2-1.51.1-1.5-1.20.20.6-0.2
Reaction time false alarm rate2.94.010.60.90.80.41.20.81.21.9-3.11.42.3-3.3-3.02.7
Reaction time premature initiation rate0.81.11.7-0.7-0.9-1.0-0.9-1.00.8-1.11.3-1.3-1.31.11.0-1.2
Reaction time premature initiations0.91.63.8-0.4-0.6-0.8-0.7-0.90.8-1.21.6-1.4-1.51.81.6-1.9
Std. dev. reaction times2.13.910.3-3.2-3.0-2.5-2.8-2.51.2-1.90.9-1.7-1.3-0.20.30.1
Reaction time trials completed0.40.72.50.30.30.20.10.10.0-0.61.0-0.4-0.81.61.4-1.5
Reaction time trials AUC0.40.82.80.20.20.2-0.00.1-0.1-0.71.1-0.4-0.91.71.5-1.6
Run reversals in cocaine runway, females1.41.42.31.31.21.11.31.20.11.2-1.41.21.5-1.2-1.11.3
Run reversals in cocaine runway, males4.44.47.7-2.8-2.8-2.6-2.7-2.61.6-2.21.4-2.2-2.00.61.2-1.0
Latency to leave start box in cocaine runway0.10.10.30.20.10.00.1-0.0-0.50.10.3-0.3-0.20.40.2-0.3
Latency to leave start box in cocaine runway, F0.20.20.60.30.30.40.40.4-0.30.5-0.30.50.4-0.5-0.60.8
Latency to leave start box in cocaine runway, M1.21.13.1-0.3-0.5-0.7-0.6-0.9-0.2-0.81.2-1.3-1.11.61.4-1.8
Std. dev. time between licks in bursts0.60.92.1-1.4-1.3-1.4-1.2-1.31.0-0.7-0.1-0.6-0.3-0.6-0.10.2
Total sessions with >9 infusions0.30.40.80.90.80.40.80.50.10.9-0.70.40.7-0.5-0.60.0
Short access day 1 total inactive lever presses1.01.32.5-1.6-1.6-1.6-1.4-1.51.4-1.00.4-1.2-0.9-0.00.1-0.4
Short access day 10 total inactive lever presses0.10.31.7-0.3-0.20.40.00.2-1.30.1-0.60.3-0.0-0.7-0.70.7
Short access day 1 total infusions0.10.10.30.30.30.20.30.30.50.3-0.30.20.2-0.3-0.20.2
Short access day 10 total infusions0.10.10.30.30.30.20.30.20.20.00.4-0.1-0.40.50.2-0.6
Short access total infusions0.10.10.40.30.30.10.20.10.60.00.3-0.1-0.30.40.1-0.5
Short access day 1 locomotion0.30.40.80.60.70.90.70.8-0.40.6-0.40.70.4-0.4-0.30.5
Short access day 10 total locomotion0.30.51.0-0.9-0.8-1.0-0.7-0.80.9-0.4-0.4-0.4-0.2-0.6-1.0-0.1
Short access total locomotion0.10.10.4-0.0-0.0-0.10.1-0.1-0.10.3-0.50.00.3-0.6-0.60.1
One hour access (0.3 mA shock)1.21.41.91.01.11.41.31.3-1.11.2-1.21.20.8-1.1-1.30.9
Compulsive drug intake1.51.85.90.50.71.00.80.9-2.41.3-1.61.21.2-1.6-1.51.4
One hour access (shock baseline)0.30.41.5-0.3-0.3-0.4-0.3-0.41.2-0.70.8-0.6-0.90.70.6-0.7
Social response proportion0.20.20.8-0.6-0.5-0.5-0.5-0.40.9-0.40.3-0.1-0.1-0.10.00.4
Social responses0.10.20.5-0.5-0.6-0.7-0.5-0.60.7-0.40.1-0.4-0.1-0.00.10.0
Social time0.91.23.9-2.0-1.7-1.3-1.6-1.4-0.7-0.7-0.1-0.7-0.7-0.8-0.50.4
Soleus weight1.13.37.3-2.7-2.6-2.4-2.3-2.32.5-1.5-0.1-1.3-0.7-1.1-0.20.8
Bone: stiffness0.20.30.9-0.1-0.2-0.3-0.2-0.4-0.0-0.40.6-0.6-0.50.70.9-0.7
Tibialis anterior weight0.31.13.01.71.51.11.51.20.21.1-0.70.81.0-0.3-0.50.3
Time to tail flick, vehicle, before self-admin0.40.42.7-1.0-0.7-0.2-0.7-0.5-1.6-0.2-0.1-0.3-0.6-0.3-0.2-0.1
Time to tail flick, vehicle, after self-admin0.10.10.8-0.20.10.20.10.2-0.80.2-0.20.2-0.0-0.3-0.90.2
Time to tail flick, test, before self-admin0.00.00.10.30.40.30.20.3-0.10.2-0.20.30.0-0.00.1-0.1
Time to tail flick, test, after self-admin0.70.71.7-1.3-1.2-1.0-1.2-1.0-0.5-0.71.0-0.6-0.70.40.4-0.1
Delta time to tail flick, vehicle, before/after SA0.70.61.51.21.10.81.10.90.50.7-0.40.70.8-0.2-0.70.4
Delta time to tail flick, test, before/after SA0.10.10.9-0.2-0.20.1-0.1-0.0-0.9-0.00.7-0.1-0.20.40.10.0
Tibia length2.77.410.5-3.2-3.2-3.2-3.2-3.22.0-2.92.5-2.8-2.71.72.0-1.9
Ambulatory time before self-admin0.20.31.0-1.0-0.9-0.6-0.8-0.6-0.3-0.40.0-0.3-0.3-0.4-0.10.3
Ambulatory time after self-admin0.60.72.0-1.4-1.2-1.3-1.3-1.2-0.1-0.7-0.1-0.7-0.3-0.4-0.0-0.1
Bone: tissue strength0.10.10.40.0-0.1-0.2-0.1-0.20.7-0.10.2-0.4-0.10.10.2-0.1
Total heroin consumption0.91.03.8-0.1-0.2-0.20.1-0.1-0.20.8-1.90.41.2-1.9-1.51.3
Bone: trabecular number0.61.02.51.51.41.61.41.4-1.00.6-0.10.80.30.40.10.1
Bone: trabecular spacing0.60.83.5-0.9-0.9-1.4-0.9-1.11.9-0.3-0.5-0.70.1-0.7-0.50.1
Bone: trabecular thickness0.40.51.40.40.50.90.40.7-1.0-0.30.80.3-0.51.20.7-0.5
Bone: trabecular tissue density0.10.21.9-0.3-0.2-0.6-0.4-0.41.4-0.20.0-0.2-0.1-0.0-0.1-0.1
Water consumed over 24 hours0.10.10.50.10.1-0.10.1-0.10.00.3-0.50.00.3-0.3-0.7-0.0
Number of responses in last shaping day0.50.54.4-0.5-0.5-0.8-0.5-0.62.1-0.5-0.2-0.3-0.1-0.3-0.00.3