Hub : Genes

Clic2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Clic2 0.18 0.07 0.0e+00 0.12 0.17 0.17 0.17 1.2e-12 2.5e-18 4.7e-18 8.6e-19
2 IL gene expression Clic2 0.24 0.12 2.2e-03 -0.01 0.02 0 0.02 5.5e-01 9.1e-02 2.7e-01 9.5e-02
3 BLA gene expression Clic2 0.17 0.09 1.0e-05 0.06 0.09 0.06 0.08 4.4e-04 1.7e-05 3.9e-04 6.2e-05
4 pVTA gene expression Clic2 0.17 0.1 3.1e-04 0.01 0.04 0.03 0.04 1.4e-01 6.1e-03 1.5e-02 8.2e-03
5 NAcc gene expression Clic2 0.05 0.03 1.9e-05 0.02 0.05 0.04 0.05 1.4e-03 2.6e-06 2.2e-05 3.9e-06
6 OFC gene expression Clic2 0.21 0.09 1.0e-03 0.01 0.13 0.04 0.03 2.1e-01 6.3e-04 4.0e-02 5.6e-02
7 Adipose mRNA stability Clic2 0.63 0.16 0.0e+00 0.57 0.59 0.6 0.6 2.3e-76 5.8e-81 3.5e-83 2.6e-83
8 Liver mRNA stability Clic2 0.34 0.11 0.0e+00 0.36 0.38 0.39 0.39 1.9e-41 1.2e-44 1.7e-46 1.5e-46
9 Liver gene expression Clic2 0.27 0.1 0.0e+00 0.24 0.28 0.27 0.27 5.8e-26 1.6e-30 5.0e-30 1.0e-29
10 Brain gene expression Clic2 0.52 0 0.0e+00 0.22 0.28 0.31 0.31 6.4e-20 5.0e-26 7.6e-29 2.3e-29
11 LHb gene expression Clic2 0.69 0 3.0e-09 0.28 0.28 0.23 0.25 2.3e-07 2.5e-07 3.3e-06 1.3e-06
12 Brain mRNA stability Clic2 0.03 0.02 1.5e-03 0.03 0.02 0 0.02 9.8e-04 5.4e-03 1.3e-01 2.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.60.93.41.81.61.00.81.41.10.20.30.5-0.20.3-0.4
Area under the delay curve0.10.20.50.1-0.30.30.6-0.3-0.4-0.3-0.30.20.5-0.30.7
BMI with tail1.85.710.3-0.2-1.9-1.5-1.5-2.0-2.43.22.9-3.0-2.82.5-2.9
BMI without tail0.81.73.6-0.8-1.9-1.1-0.9-1.5-1.51.21.3-1.8-1.21.1-0.9
Body weight5.724.031.0-2.5-5.1-4.5-4.4-5.1-5.35.35.3-5.6-5.24.9-4.9
Weight adjusted by age1.71.94.0-1.3-2.0-1.7-1.5-1.8-1.61.20.9-1.2-0.80.3-1.5
Bone surface0.91.62.5-0.8-1.2-1.5-1.6-1.1-1.11.21.3-1.1-1.31.3-1.3
Bone volume0.61.02.00.4-0.4-0.6-0.8-0.3-0.51.31.4-0.9-1.41.4-1.4
Breakpoint value in progressive ratio session2.73.04.10.71.81.71.81.61.6-2.0-1.91.71.9-1.91.9
Number of licking bursts0.20.30.6-0.7-0.3-0.10.0-0.10.1-0.8-0.70.40.7-0.60.7
Context. condit. distance diff. score0.50.62.1-1.5-0.1-1.2-1.3-0.30.0-1.0-0.50.70.3-0.50.5
Locomotion velocity, session 10.20.20.7-0.8-0.3-0.3-0.2-0.20.1-0.6-0.60.40.6-0.60.5
Locomotion distance, session 11.62.12.70.91.61.61.61.41.3-1.4-1.51.51.5-1.51.4
Locomotion velocity, session 21.11.32.9-0.8-0.10.50.70.10.4-1.5-1.71.01.7-1.71.4
Locomotion distance, session 21.21.62.70.01.00.91.00.91.0-1.6-1.61.61.6-1.61.5
Locomotion velocity, session 30.50.61.10.70.61.01.10.80.9-0.4-0.60.30.9-0.70.6
Locomotion distance, session 31.92.13.10.81.41.21.21.31.3-1.7-1.61.61.6-1.61.7
Stereotopy head waving bouts, day 30.70.82.5-1.6-1.4-1.1-1.0-1.2-0.90.10.1-0.5-0.10.1-0.2
Stereotopy head waving duration, day 30.60.71.9-1.4-1.3-1.0-0.9-1.0-0.70.30.3-0.7-0.30.3-0.5
Locomotion velocity, session 70.60.61.60.20.80.20.10.50.6-1.1-1.01.30.9-1.00.7
Locomotion distance, session 74.25.47.61.72.42.12.12.22.3-2.5-2.52.82.5-2.52.2
Stereotopy head waving bouts, day 70.40.41.0-1.0-0.6-0.20.0-0.4-0.2-0.7-0.80.40.9-0.80.8
Stereotopy head waving duration, day 70.80.92.7-1.6-1.6-1.2-0.9-1.4-1.20.10.1-0.5-0.10.1-0.0
Locomotion velocity, session 82.42.810.8-3.3-2.1-2.1-1.8-1.9-1.2-1.3-1.00.30.8-1.10.9
Locomotion distance, session 81.01.53.6-0.90.6-0.2-0.20.30.5-1.9-1.61.71.4-1.61.5
Degree of sensitization distance0.10.10.2-0.5-0.3-0.4-0.4-0.20.0-0.3-0.20.20.2-0.2-0.1
Degree of sensitization stereotypy0.60.71.5-0.9-0.4-0.00.2-0.3-0.1-1.1-1.20.81.1-1.11.2
Conditioned locomotion2.12.54.0-0.4-1.3-0.9-0.9-1.4-1.72.01.9-1.9-1.91.9-1.7
Cocaine response after cond. corrected0.20.20.50.70.60.70.60.50.30.0-0.20.20.1-0.10.1
Cocaine response after cond. not corrected0.60.61.1-0.8-1.0-0.9-0.8-0.9-0.90.70.6-0.8-0.70.6-0.6
Cocaine response before conditioning4.45.49.9-2.5-3.1-2.8-2.7-2.8-2.51.61.8-2.1-1.71.7-1.6
Saline control response1.41.83.60.7-0.7-0.5-0.7-0.5-0.71.91.8-1.7-1.61.8-1.7
Bone: connectivity density0.20.31.00.81.00.2-0.00.80.60.10.30.5-0.30.3-0.3
Bone: cortical apparent density0.81.13.21.80.60.90.80.60.21.31.2-0.9-0.91.0-1.2
Bone: cortical area0.30.40.9-0.7-0.9-0.8-0.7-0.9-0.80.30.3-0.5-0.30.3-0.3
Bone: cortical porosity2.83.15.60.40.81.41.71.21.6-2.1-2.21.62.4-2.22.3
Bone: cortical porosity1.71.94.1-0.6-0.10.40.70.30.8-1.9-1.91.32.0-1.92.0
Bone: cortical thickness0.40.73.11.80.81.21.30.70.20.50.2-0.0-0.10.2-0.2
Bone: cortical thickness1.01.25.12.31.21.31.21.00.60.90.7-0.3-0.60.8-0.7
Bone: cortical tissue density0.81.02.81.70.50.80.70.50.21.31.2-0.9-0.91.0-1.2
Condit. Reinf. active minus inactive responses0.10.10.3-0.3-0.1-0.2-0.2-0.10.1-0.5-0.50.20.3-0.40.4
Condit. Reinf. active-inactive response ratio0.00.00.10.2-0.10.20.2-0.0-0.10.10.0-0.4-0.10.1-0.0
Condit. Reinf. active responses0.00.00.1-0.10.2-0.1-0.10.10.1-0.3-0.20.1-0.0-0.10.2
Condit. Reinf. inactive responses0.70.82.51.01.61.10.91.21.0-0.5-0.41.00.4-0.40.4
Incentive salience index mean0.50.61.9-1.4-0.5-0.8-0.8-0.7-0.5-0.9-0.80.40.5-0.70.7
Condit. Reinf. lever presses0.70.92.7-1.6-0.1-0.7-0.6-0.5-0.3-1.4-1.30.90.7-1.11.1
Condit. Reinf. active minus inactive responses0.91.21.7-0.8-1.3-1.1-1.1-1.0-0.91.01.2-1.2-1.11.1-1.1
Condit. Reinf. active-inactive response ratio2.12.22.7-0.9-1.6-1.4-1.3-1.5-1.51.51.6-1.6-1.51.6-1.5
Condit. Reinf. active responses0.10.10.2-0.4-0.4-0.4-0.5-0.10.10.10.3-0.3-0.20.3-0.3
Condit. Reinf. inactive responses0.00.00.2-0.10.2-0.1-0.30.40.5-0.10.10.1-0.00.1-0.1
Condit. Reinf. lever presses0.10.10.6-0.00.40.0-0.10.60.8-0.6-0.20.40.3-0.20.2
Condit. Reinf. lever reinforcers received0.10.10.2-0.4-0.3-0.4-0.50.00.20.00.3-0.2-0.20.3-0.2
Conditioned reinforcement - actives0.60.61.80.7-0.0-0.0-0.1-0.0-0.31.11.0-0.6-1.11.3-0.8
Conditioned reinforcement - inactives0.10.10.40.60.30.40.40.30.20.30.3-0.1-0.30.4-0.0
Conditioned locomotion2.02.34.5-0.1-0.9-1.1-1.2-1.0-1.22.02.0-1.7-2.02.1-1.8
Patch foraging indifference point 0 sec0.50.82.51.61.01.00.91.21.1-0.5-0.20.60.4-0.70.4
Patch foraging indifference point AUC0.40.41.4-1.0-1.2-0.8-0.6-1.0-0.80.2-0.1-0.30.10.0-0.1
Delay disc. indifference point, 0s delay0.50.61.8-0.8-1.0-0.7-0.5-1.3-1.30.30.2-0.6-0.40.50.1
Delay disc. indifference point, 16s delay2.22.24.71.51.31.92.21.31.1-1.1-1.31.41.6-1.31.6
Delay disc. indifference point, 2s delay0.60.61.6-1.0-1.3-0.8-0.6-1.2-1.20.10.4-0.8-0.30.2-0.1
Delay disc. indifference point, 24s delay0.20.10.60.50.10.60.80.20.3-0.1-0.20.20.4-0.20.5
Delay disc. indifference point, 4s delay1.92.03.4-1.2-1.8-1.3-1.2-1.8-1.81.31.3-1.6-1.21.4-1.1
Delay disc. indifference point, 8s delay0.30.30.90.20.20.50.60.20.2-0.6-0.60.70.7-0.31.0
Indifference point function ln k0.60.82.1-1.00.2-0.00.00.20.4-1.4-1.11.11.0-1.31.2
Indifference point function log k0.60.82.1-1.00.2-0.00.00.20.4-1.4-1.11.11.0-1.31.2
Patch foraging total patch changes 0 sec0.71.13.11.81.21.21.11.31.2-0.7-0.40.80.6-0.80.6
Patch foraging total patch changes 12 sec0.50.72.11.40.81.11.11.01.0-0.3-0.30.60.6-0.40.2
Patch foraging total patch changes 18 sec0.71.04.22.01.31.21.01.31.10.20.10.30.0-0.1-0.3
Patch foraging total patch changes 24 sec3.64.49.13.02.72.82.72.72.3-1.0-1.01.61.2-1.11.0
Patch foraging total patch changes 6 sec0.71.15.62.41.01.41.31.20.90.30.30.1-0.10.2-0.2
Patch foraging time to switch 0 sec0.91.44.02.01.11.21.00.90.31.41.2-0.9-1.11.2-1.0
Patch foraging water rate 0 sec0.00.10.5-0.00.0-0.2-0.20.00.0-0.3-0.20.70.2-0.30.0
Patch foraging water rate 12 sec0.10.10.30.10.30.00.10.0-0.0-0.4-0.40.60.2-0.10.4
Patch foraging water rate 18 sec0.20.30.5-0.5-0.4-0.6-0.6-0.5-0.50.40.6-0.4-0.70.5-0.6
Patch foraging water rate 24 sec0.10.20.5-0.1-0.3-0.2-0.2-0.4-0.50.40.5-0.2-0.50.5-0.7
Patch foraging water rate 6 sec0.40.61.10.41.00.90.90.80.7-0.7-0.71.10.8-0.80.6
Seeking ratio, delayed vs. immediate footshock0.10.10.5-0.7-0.6-0.3-0.2-0.3-0.1-0.2-0.2-0.00.20.0-0.0
Distance traveled before self-admin0.80.92.5-1.6-0.8-1.4-1.5-1.0-0.90.20.5-0.6-0.70.5-0.1
Distance traveled after self-admin1.01.13.0-1.7-1.3-1.5-1.6-1.0-0.70.40.6-1.0-0.70.6-0.5
Extensor digitorum longus weight0.31.23.0-1.4-1.4-1.7-1.7-1.3-1.10.30.5-0.5-0.60.5-0.5
Bone: elastic displacement0.20.30.70.60.40.80.80.60.5-0.3-0.40.30.5-0.40.3
Bone: elastic work0.00.00.10.1-0.20.20.3-0.1-0.20.30.2-0.3-0.10.1-0.2
Bone: endosteal estimation4.59.818.9-4.3-4.3-4.2-4.1-3.9-3.21.51.7-2.6-1.81.7-1.7
Bone: endosteal perimeter2.34.813.2-3.6-2.9-3.3-3.3-2.6-2.00.30.7-1.2-0.80.7-0.6
Epididymis fat weight2.14.919.44.42.63.13.02.41.41.51.2-0.4-0.91.0-0.8
Delta time in closed arm before/after self-admin0.40.40.6-0.1-0.5-0.6-0.6-0.6-0.70.60.7-0.6-0.80.5-0.7
Delta time in open arm before/after self-admin0.00.00.2-0.5-0.1-0.2-0.30.10.3-0.2-0.10.00.10.10.2
Diff in mean of infusions in LGA sessions2.02.23.40.91.91.51.51.41.2-1.4-1.61.71.5-1.51.5
Delay discount exponential model param0.10.10.4-0.10.3-0.4-0.60.20.30.20.3-0.1-0.50.3-0.7
Extinction: sum of active levers before priming3.63.54.51.22.12.12.12.02.0-1.6-1.91.81.9-1.72.0
Active lever presses in extinction session 60.50.51.41.11.11.21.10.90.50.00.2-0.0-0.10.20.2
Bone: final force0.71.22.20.3-1.0-0.5-0.4-1.0-1.21.51.3-1.4-1.21.3-1.3
Bone: final moment0.91.42.50.2-1.0-0.7-0.6-1.0-1.21.61.5-1.4-1.31.4-1.4
Food consumed during 24 hour testing period1.72.02.4-1.2-1.4-1.4-1.4-1.5-1.51.31.5-1.5-1.51.5-1.2
Glucose2.53.79.7-3.1-2.5-3.1-3.1-2.3-1.7-0.10.4-0.5-0.60.3-0.3
Heart weight0.40.61.3-0.7-1.0-0.9-0.8-0.9-0.80.30.6-0.6-0.81.2-0.4
Delay discount hyperbolic model param0.10.10.30.20.5-0.1-0.40.50.50.20.10.1-0.30.1-0.5
Intermittent access intake day 1-15 change0.70.71.3-0.2-0.8-0.6-0.6-0.8-0.91.10.9-1.1-0.90.7-1.1
Intermittent access intake escalation1.31.31.7-1.0-1.2-1.2-1.2-1.3-1.31.21.0-1.2-1.00.8-1.2
Intermittent access intake escalation 21.81.84.6-2.2-1.7-2.0-1.9-1.7-1.40.50.4-0.8-0.60.1-0.6
Intermitt. access day 1 inactive lever presses0.20.21.1-1.1-0.4-0.5-0.5-0.4-0.2-0.3-0.2-0.1-0.10.30.5
Intermitt. access day 15 inactive lever presses0.40.40.9-0.9-0.9-0.7-0.6-0.8-0.80.10.3-0.6-0.40.8-0.2
Intermitt. access escalation Index2.21.92.50.81.51.41.51.41.4-1.1-1.51.61.6-1.61.0
Intermittent access day 1 total infusions0.30.30.90.90.80.70.50.70.40.20.30.1-0.40.60.0
Intermittent access day 15 total infusions1.31.43.60.5-0.2-0.2-0.4-0.3-0.71.71.6-1.3-1.71.9-1.5
Intermittent access terminal intake (last 3 days)1.11.22.70.4-0.3-0.3-0.4-0.4-0.71.61.5-1.3-1.51.3-1.4
Intermittent access total infusions1.11.22.90.6-0.1-0.2-0.3-0.2-0.51.51.6-1.2-1.61.7-1.2
Intermittent access day 1 locomotion1.11.12.2-0.5-0.7-0.7-0.8-0.8-0.91.41.2-1.3-1.31.5-1.1
Intermittent access day 15 total locomotion4.14.55.5-1.3-2.0-2.0-2.1-2.0-2.22.22.2-2.3-2.32.3-2.2
Intermittent access total locomotion4.85.47.1-1.4-2.1-2.2-2.2-2.2-2.42.52.5-2.6-2.72.6-2.3
Intermittent access standard deviation1.31.33.30.2-0.8-0.5-0.5-0.7-0.91.51.5-1.3-1.41.8-1.3
Left kidney weight1.33.86.7-2.1-2.5-2.2-2.1-2.6-2.61.31.3-1.6-1.61.4-1.2
Right kidney weight2.57.111.0-2.3-3.1-3.0-2.8-3.3-3.32.22.3-2.6-2.52.4-1.9
Cocaine induced anxiety0.91.13.3-1.7-0.8-1.6-1.8-0.9-0.70.40.6-0.5-0.80.7-0.4
Post-drug Anxiety0.50.62.5-1.6-0.7-1.2-1.3-0.8-0.5-0.10.0-0.2-0.10.1-0.2
Baseline Anxiety1.51.62.70.81.01.41.61.21.3-1.2-1.41.21.6-1.50.9
Tail length2.47.116.3-3.6-4.0-3.4-3.1-3.7-3.20.91.3-2.1-1.41.3-0.8
Length with tail3.111.418.4-3.3-4.3-3.9-3.7-4.2-4.12.52.7-3.2-2.82.6-2.5
Length without tail4.39.513.2-2.3-3.2-3.2-3.2-3.5-3.63.02.9-3.0-3.02.6-3.1
Times rat made contact with spout3.03.55.81.82.22.42.32.42.3-1.5-1.41.41.5-1.11.3
Lifetime Intake0.60.72.00.5-0.0-0.1-0.3-0.1-0.41.11.2-0.8-1.31.4-0.8
Liver weight, left1.42.24.3-1.9-2.0-2.0-2.1-1.6-1.20.71.0-1.3-1.11.1-0.9
Liver weight, right3.76.214.5-3.5-3.8-3.3-3.0-3.5-2.90.70.8-2.0-0.90.7-0.9
Locomotor activity2.54.08.2-2.8-2.6-2.8-2.9-2.2-1.80.81.4-1.6-1.41.0-1.3
Locomotor testing distance0.81.43.0-1.2-1.3-1.6-1.7-1.0-0.80.71.1-1.0-1.00.8-1.2
Locomotor testing rearing1.32.03.8-1.6-1.6-1.9-2.0-1.4-1.20.91.1-1.2-1.21.1-1.4
Locomotion in novel chamber0.30.31.0-0.20.00.30.40.10.2-1.0-0.80.50.7-0.80.9
Locomotion in novel chamber post-restriction0.50.61.1-0.2-0.7-0.6-0.7-0.6-0.70.81.1-1.0-1.00.8-0.7
Fecal boli incidents, locomotor time 10.10.20.40.30.40.0-0.20.40.40.40.6-0.1-0.40.6-0.5
Change in fecal boli incidents, locomotor task0.80.81.4-0.5-0.9-0.7-0.7-1.0-1.10.91.0-1.2-1.01.0-0.5
Time >=10cm from walls, locomotor time 13.43.44.5-1.6-1.9-2.1-2.1-2.0-2.01.61.8-1.8-1.91.8-1.6
Bouts of movement, locomotor time 10.60.61.6-0.50.1-0.2-0.30.20.5-1.3-1.01.00.9-0.91.2
Total resting periods, locomotor time 10.20.20.6-0.7-0.3-0.6-0.6-0.2-0.0-0.6-0.30.40.3-0.40.8
Rest time, locomotor task time 12.73.04.8-1.6-1.9-2.0-2.2-1.7-1.51.41.7-1.8-1.71.7-1.3
Distance moved, locomotor task time 11.21.32.00.70.91.01.20.80.8-1.3-1.41.41.4-1.41.0
Vertical activity count, locomotor time 10.60.61.00.50.80.80.90.60.6-1.0-0.91.00.9-0.80.5
Time >=10cm from walls, locomotor time 22.72.83.5-1.0-1.7-1.8-1.9-1.7-1.71.51.8-1.7-1.81.7-1.8
Bouts of movement, locomotor time 20.80.93.2-1.8-1.4-1.3-1.2-1.2-0.8-0.10.0-0.5-0.20.20.3
Total resting periods, locomotor time 21.11.24.7-2.2-1.5-1.5-1.4-1.2-0.7-0.3-0.2-0.40.0-0.00.4
Rest time, locomotor task time 22.12.46.3-2.5-1.7-2.3-2.4-1.8-1.50.40.7-0.9-0.90.7-0.3
Distance moved, locomotor task time 20.50.52.61.60.70.91.00.60.20.50.30.1-0.20.3-0.8
Vertical activity count, locomotor time 20.20.20.70.90.40.40.40.30.10.40.4-0.1-0.30.5-0.8
Light reinforcement 10.10.21.01.00.60.60.70.3-0.00.20.10.2-0.0-0.1-0.3
Light reinforcement 22.53.35.1-0.7-1.7-1.5-1.5-2.0-2.32.02.0-1.8-2.01.8-2.0
Bone: marrow area4.69.918.8-4.2-4.3-4.2-4.1-3.9-3.21.61.8-2.6-1.91.8-1.7
Bone: maximum diameter1.32.48.2-2.9-2.0-2.3-2.2-1.9-1.2-0.7-0.4-0.10.2-0.40.5
Bone: maximum force0.71.32.0-0.1-1.1-0.7-0.7-1.2-1.41.41.3-1.4-1.21.2-1.2
Bone: maximum moment1.01.72.5-0.2-1.3-1.0-1.0-1.2-1.41.61.5-1.5-1.41.4-1.4
Mean time between licks in bursts1.31.85.7-2.4-1.7-2.0-2.0-1.6-1.20.10.4-0.6-0.60.4-0.3
Mean num. licks in bursts0.60.72.21.51.21.10.91.20.90.30.30.0-0.30.4-0.4
Cd content in liver2.42.74.90.7-0.7-0.8-0.9-1.0-1.52.22.2-1.6-2.22.2-2.0
Co content in liver0.50.61.81.30.61.00.90.70.30.70.6-0.2-0.50.7-0.6
Cu content in liver4.96.010.53.03.23.13.03.12.8-1.4-1.52.21.6-1.51.5
Fe content in liver1.51.83.60.4-0.7-0.5-0.5-0.7-1.01.91.9-1.7-1.61.7-1.8
K content in liver2.22.23.70.31.11.11.21.11.2-1.8-1.91.71.8-1.91.7
Mg content in liver2.32.45.2-0.90.50.20.30.71.2-2.3-2.11.92.0-2.12.0
Mn content in liver1.71.98.4-2.9-1.4-1.7-1.6-1.2-0.4-1.2-1.00.40.9-1.10.9
Na content in liver2.02.13.70.20.91.11.30.80.9-1.8-1.91.71.8-1.91.9
Rb content in liver0.40.61.31.11.20.90.71.11.0-0.3-0.20.60.2-0.10.2
Se content in liver2.02.58.2-2.9-1.4-1.3-1.0-1.1-0.3-1.9-1.80.91.6-1.71.7
Sr content in liver2.22.02.5-1.1-1.3-1.3-1.4-1.4-1.61.51.4-1.6-1.61.5-1.3
Zn content in liver0.10.10.20.00.40.1-0.00.40.4-0.4-0.20.50.1-0.10.3
Bone: minimum diameter1.93.58.6-2.9-2.4-2.6-2.6-2.3-1.90.60.9-1.2-1.00.8-0.8
Time in familiar zone, hab. session 13.33.16.72.62.32.32.12.52.3-0.6-0.81.00.9-0.70.6
Time in novel zone, hab. session 15.45.38.7-2.5-2.6-2.9-3.0-2.7-2.61.51.9-1.7-2.01.8-1.7
Total zone transitions, hab. session 10.40.51.00.20.70.50.50.60.7-0.9-0.81.00.8-0.90.8
Total locomotion distance, hab. session 10.70.91.40.41.10.80.90.90.8-1.1-1.01.21.0-1.01.0
Locomotion velocity, hab. session 11.31.82.30.61.41.31.41.21.2-1.5-1.51.51.5-1.51.5
Time in familiar zone, hab. session 20.40.41.11.01.10.90.80.90.70.30.20.2-0.00.1-0.1
Time in novel zone, hab. session 20.50.51.0-0.7-1.0-0.8-0.8-0.8-0.70.50.5-0.6-0.50.5-0.7
Total zone transitions, hab. session 20.30.30.60.20.60.60.80.40.2-0.6-0.70.70.7-0.70.5
Total locomotion distance, hab. session 20.40.61.30.51.10.80.80.80.6-0.7-0.70.90.6-0.60.6
Locomotion velocity, hab. session 20.91.21.80.41.41.11.11.00.8-1.2-1.21.41.1-1.11.1
Novel to familiar place preference ratio0.10.10.40.60.40.50.60.40.3-0.2-0.20.40.2-0.20.1
Novelty place preference0.00.00.10.2-0.10.10.2-0.0-0.10.0-0.00.10.0-0.0-0.1
Time in novel zone, NPP test0.10.10.2-0.0-0.4-0.3-0.2-0.4-0.50.30.3-0.2-0.30.3-0.4
Total zone transitions, NPP test0.20.30.70.10.70.40.30.60.6-0.7-0.70.80.5-0.60.5
Total locomotion distance, NPP test0.30.41.40.81.20.80.70.90.6-0.3-0.30.70.1-0.10.1
Locomotion velocity, NPP test1.01.43.21.11.81.41.31.51.3-1.0-1.01.30.8-0.80.7
Intraocular pressure0.20.20.50.40.50.1-0.10.40.20.50.7-0.1-0.70.7-0.7
Delta distance traveled before/after self-admin0.20.30.7-0.1-0.8-0.3-0.2-0.2-0.10.60.5-0.8-0.30.5-0.8
Delta ambulatory time before/after self-admin0.10.10.4-0.4-0.7-0.3-0.3-0.3-0.10.20.1-0.4-0.00.1-0.3
Parametrial fat weight1.73.46.60.0-1.2-1.0-1.0-1.5-2.02.62.3-2.1-2.32.2-2.2
Pavlov. Cond. lever latency1.62.16.02.51.21.20.91.10.51.81.7-0.9-1.41.5-1.7
Pavlov. Cond. magazine entry latency1.01.22.6-1.6-0.2-0.3-0.2-0.00.5-1.6-1.60.91.4-1.51.4
Pavlov. Cond. change in total contacts0.70.82.2-1.5-1.3-1.0-0.8-1.3-1.0-0.5-0.5-0.20.3-0.40.4
Pavlov. Cond. index score1.62.05.5-2.3-0.8-0.8-0.6-0.6-0.0-1.9-1.91.01.6-1.71.8
Pavlov. Cond. latency score1.92.46.1-2.5-0.8-0.8-0.5-0.7-0.1-2.1-2.01.11.7-1.82.0
Pavlov. Cond. lever contacts1.41.75.8-2.4-1.4-1.4-1.1-1.4-0.9-1.3-1.20.50.9-1.01.2
Pavlov. Cond. magazine entry number0.50.61.41.1-0.00.10.0-0.2-0.61.21.2-0.6-1.01.0-0.9
Pavlov. Cond. intertrial magazine entries0.20.30.80.90.40.30.20.2-0.00.60.7-0.2-0.60.6-0.5
Pavlov. Cond. lever-magazine prob. diff.1.72.14.7-2.2-0.6-0.6-0.4-0.50.1-2.0-2.01.11.7-1.81.9
Pavlov. Cond. response bias0.80.93.7-1.9-0.8-0.9-0.7-0.7-0.2-1.2-1.10.40.9-0.90.9
Pavlov. Cond. lever latency0.10.10.4-0.2-0.5-0.2-0.1-0.6-0.70.40.1-0.3-0.10.00.0
Pavlov. Cond. magazine entry latency0.10.10.5-0.7-0.3-0.3-0.2-0.3-0.2-0.4-0.40.20.3-0.30.3
Pavlov. Cond. change in total contacts0.00.00.00.1-0.00.10.10.10.10.10.2-0.1-0.10.2-0.2
Pavlov. Cond. index score0.00.10.2-0.4-0.1-0.1-0.10.00.2-0.5-0.30.20.2-0.20.2
Pavlov. Cond. latency score0.00.10.2-0.3-0.00.00.00.10.2-0.4-0.30.20.3-0.20.2
Pavlov. Cond. lever contacts0.10.10.30.60.40.20.10.50.40.20.4-0.1-0.40.5-0.5
Pavlov. Cond. magazine entry number0.00.00.10.10.20.0-0.00.20.3-0.0-0.0-0.00.1-0.10.1
Pavlov. Cond. intertrial magazine entries0.70.91.8-1.2-0.4-0.4-0.3-0.10.4-1.4-1.30.71.2-1.31.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.2-0.4-0.1-0.2-0.2-0.00.1-0.4-0.20.20.2-0.10.1
Pavlov. Cond. response bias0.00.10.20.20.20.0-0.10.20.20.10.3-0.1-0.30.4-0.4
Time in closed arm before self-admin0.20.20.60.70.50.70.70.50.30.10.1-0.0-0.00.10.1
Time in closed arm after self-admin0.20.30.70.90.10.50.6-0.0-0.40.60.5-0.5-0.50.2-0.6
Time in open arm before self-admin0.10.10.3-0.5-0.3-0.3-0.3-0.10.1-0.5-0.40.10.4-0.20.4
Time in open arm after self-admin0.60.71.5-0.70.1-0.1-0.10.51.0-1.2-1.00.81.1-0.81.1
Bone: periosteal estimation2.55.110.1-2.9-3.2-3.0-2.9-2.8-2.41.11.3-1.9-1.41.3-1.2
Bone: periosteal perimeter1.72.86.3-2.5-2.4-2.4-2.3-2.2-1.80.40.6-1.0-0.70.6-0.5
Bone: post-yield work1.52.05.1-1.9-1.6-2.1-2.3-1.5-1.20.61.0-0.9-1.10.9-0.9
Progressive ratio test 1 active lever presses0.10.10.40.40.20.30.20.1-0.10.70.3-0.3-0.40.6-0.4
Progressive ratio test 1 breakpoint0.20.20.60.60.40.40.30.20.00.80.4-0.3-0.40.5-0.6
Progressive ratio test 1 inactive lever presses0.60.61.81.31.11.11.01.00.70.1-0.00.3-0.10.60.0
Progressive ratio test 2 active lever presses0.40.41.31.20.90.80.60.80.50.50.4-0.0-0.50.6-0.7
Progressive ratio test 2 breakpoint0.50.61.81.41.21.00.81.10.80.30.30.2-0.30.5-0.5
Progressive ratio test 2 inactive lever presses0.30.41.3-0.0-0.4-0.3-0.3-0.4-0.60.60.7-0.6-0.81.1-0.7
Incentive Sensitization - Responses1.01.01.91.21.31.31.21.41.3-0.7-0.60.80.5-0.40.5
Incentive Sensitization - Breakpoint0.80.81.71.21.31.21.11.31.1-0.6-0.50.70.4-0.30.3
Sum of active levers in priming session hrs 5-60.20.20.6-0.00.40.50.40.60.7-0.5-0.40.30.5-0.40.8
Progressive ratio1.31.52.8-0.3-1.3-0.8-0.8-1.2-1.31.41.5-1.7-1.31.4-1.2
Food seeking constrained by brief footshock0.00.10.20.30.20.20.10.20.20.30.10.0-0.20.5-0.3
Seeking ratio, punishment vs. effort1.41.73.00.41.40.90.91.41.6-1.4-1.61.71.4-1.31.2
Retroperitoneal fat weight0.20.61.30.1-0.7-0.3-0.3-0.6-0.81.11.0-1.1-0.91.1-0.7
Reaction time number correct0.81.22.71.20.30.40.30.3-0.11.61.4-1.0-1.31.5-1.5
Reaction time mean minus median3.95.112.6-3.6-2.9-3.3-3.2-2.9-2.50.41.0-1.4-1.10.7-0.7
Reaction time mean minus median AUC2.73.59.0-3.0-2.3-2.7-2.7-2.4-2.00.30.8-1.0-0.90.6-0.5
Reaction time num false alarms2.12.85.60.10.71.11.40.91.2-2.1-2.11.72.2-2.42.3
Reaction time num false alarms AUC2.23.06.6-0.30.40.91.20.71.1-2.2-2.31.82.4-2.62.5
Reaction time trials correct on left0.81.22.71.20.30.40.30.3-0.11.61.4-1.0-1.31.5-1.5
Reaction time trials on left0.81.22.81.00.20.30.20.2-0.21.71.5-1.0-1.31.5-1.6
Reaction time mean2.73.811.9-3.5-2.2-3.0-3.0-2.4-1.9-0.20.3-0.6-0.60.4-0.1
Reaction time mean AUC3.04.011.9-3.4-2.4-3.0-3.0-2.5-2.0-0.00.4-0.7-0.70.4-0.2
Median of all reaction times1.62.27.8-2.8-1.6-2.3-2.3-1.8-1.4-0.4-0.0-0.2-0.30.00.1
Reaction time omissions1.62.17.4-2.7-1.8-2.1-2.0-1.9-1.50.10.2-0.6-0.50.6-0.3
Reaction time false alarm rate3.14.39.5-0.90.30.50.90.51.1-2.9-2.82.22.9-3.13.1
Reaction time premature initiation rate1.01.42.2-0.4-1.1-1.0-0.9-1.2-1.31.11.3-1.3-1.31.5-1.3
Reaction time premature initiations1.72.44.40.2-1.0-0.7-0.7-1.0-1.42.02.0-1.8-1.92.1-2.1
Std. dev. reaction times3.04.213.8-3.7-2.6-3.0-2.9-2.6-2.1-0.10.3-0.8-0.60.4-0.0
Reaction time trials completed0.81.22.81.00.20.30.20.2-0.21.71.5-1.0-1.31.5-1.6
Reaction time trials AUC0.91.33.01.00.10.20.10.2-0.21.71.6-1.1-1.51.7-1.6
Run reversals in cocaine runway, females1.41.31.71.11.21.31.31.31.3-0.9-1.11.31.2-1.01.0
Run reversals in cocaine runway, males3.63.56.9-2.4-2.4-2.6-2.5-2.4-2.10.91.0-1.4-1.20.6-0.9
Latency to leave start box in cocaine runway0.20.30.80.2-0.2-0.00.1-0.4-0.60.80.5-0.6-0.50.3-0.9
Latency to leave start box in cocaine runway, F0.10.10.3-0.10.2-0.00.00.10.1-0.3-0.40.40.4-0.5-0.1
Latency to leave start box in cocaine runway, M1.61.53.80.7-0.50.00.1-0.6-1.12.01.7-1.6-1.51.4-1.5
Std. dev. time between licks in bursts0.80.93.0-1.7-1.3-1.4-1.3-1.2-0.8-0.4-0.2-0.10.1-0.20.3
Total sessions with >9 infusions0.20.30.80.2-0.2-0.2-0.2-0.3-0.50.90.6-0.5-0.60.8-0.6
Short access day 1 total inactive lever presses0.50.62.6-1.6-0.7-1.1-1.1-0.8-0.5-0.4-0.2-0.0-0.10.10.5
Short access day 10 total inactive lever presses0.40.41.2-0.80.4-0.0-0.10.30.5-1.1-0.80.60.6-0.71.0
Short access day 1 total infusions0.10.10.20.30.40.30.30.40.4-0.1-0.20.30.10.20.3
Short access day 10 total infusions0.20.21.00.2-0.1-0.0-0.1-0.1-0.30.50.6-0.5-0.61.0-0.1
Short access total infusions0.20.21.10.2-0.1-0.0-0.1-0.1-0.20.50.5-0.4-0.61.0-0.1
Short access day 1 locomotion0.10.20.60.50.70.30.20.60.40.30.00.3-0.10.4-0.2
Short access day 10 total locomotion0.70.82.9-1.7-1.2-1.2-1.1-1.1-0.7-0.0-0.1-0.50.0-0.30.1
Short access total locomotion0.20.20.4-0.5-0.5-0.4-0.4-0.5-0.50.60.3-0.5-0.30.6-0.5
One hour access (0.3 mA shock)0.10.10.50.30.60.20.20.40.2-0.4-0.10.4-0.1-0.30.7
Compulsive drug intake2.72.74.70.61.61.51.61.61.7-1.8-1.81.61.6-1.62.2
One hour access (shock baseline)2.12.43.1-0.9-1.5-1.7-1.8-1.6-1.71.51.7-1.5-1.71.5-1.5
Social response proportion0.20.20.7-0.8-0.7-0.8-0.8-0.6-0.3-0.1-0.1-0.10.1-0.10.2
Social responses0.20.20.6-0.6-0.8-0.7-0.7-0.5-0.30.10.1-0.30.10.10.0
Social time1.31.76.7-2.6-1.5-1.9-1.8-1.7-1.3-0.3-0.3-0.2-0.0-0.20.6
Soleus weight1.44.214.8-3.9-2.7-3.0-2.8-2.6-1.8-0.7-0.5-0.20.2-0.40.5
Bone: stiffness0.20.30.70.5-0.10.20.2-0.2-0.40.90.6-0.6-0.50.5-0.6
Tibialis anterior weight0.31.12.91.71.11.41.41.21.1-0.5-0.60.70.8-0.60.8
Time to tail flick, vehicle, before self-admin0.50.61.5-1.2-0.6-1.0-1.0-1.0-1.1-0.20.3-0.4-0.50.00.1
Time to tail flick, vehicle, after self-admin0.10.10.3-0.5-0.1-0.4-0.5-0.2-0.30.10.3-0.2-0.40.00.2
Time to tail flick, test, before self-admin0.20.20.30.60.20.30.30.2-0.10.30.5-0.4-0.50.5-0.5
Time to tail flick, test, after self-admin1.31.33.0-1.7-1.3-1.6-1.6-1.3-1.10.50.7-0.9-0.80.4-0.8
Delta time to tail flick, vehicle, before/after SA0.40.30.70.80.70.80.70.90.8-0.0-0.30.50.3-0.20.4
Delta time to tail flick, test, before/after SA0.30.30.6-0.5-0.3-0.7-0.8-0.5-0.50.60.5-0.4-0.60.4-0.6
Tibia length2.57.212.1-2.9-3.5-3.2-3.1-3.3-3.11.81.9-2.6-2.11.9-2.0
Ambulatory time before self-admin0.20.20.8-0.9-0.2-0.5-0.5-0.4-0.3-0.3-0.20.10.1-0.60.4
Ambulatory time after self-admin0.50.52.5-1.6-0.9-1.0-1.1-0.6-0.3-0.20.1-0.5-0.20.10.1
Bone: tissue strength0.10.10.20.3-0.10.00.1-0.3-0.50.40.3-0.1-0.20.1-0.2
Total heroin consumption1.31.63.7-0.70.40.40.60.20.5-1.8-1.91.41.7-1.61.7
Bone: trabecular number0.81.23.92.01.71.41.31.41.1-0.1-0.20.80.2-0.20.2
Bone: trabecular spacing0.50.72.2-1.5-1.4-0.8-0.5-1.2-0.9-0.3-0.5-0.30.3-0.30.4
Bone: trabecular thickness0.50.51.71.31.10.70.41.00.80.40.50.1-0.50.6-0.5
Bone: trabecular tissue density0.00.00.3-0.2-0.5-0.1-0.1-0.3-0.20.1-0.0-0.30.00.0-0.1
Water consumed over 24 hours0.10.10.3-0.50.00.20.30.0-0.0-0.5-0.40.20.3-0.20.4
Number of responses in last shaping day0.10.10.2-0.2-0.5-0.3-0.2-0.3-0.20.20.2-0.2-0.10.3-0.4