Hub : Genes

Clba1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	mRNA stability	Clba1	0.2	0.15	9.9e-03	0.16	0.11	0.1	0.11	1.8e-03	8.9e-03	1.4e-02	8.7e-03
2	Eye	intron excision ratio	chr6_131886607_131888095	0.24	0.17	5.0e-03	0.08	0.14	0.08	0.1	2.6e-02	3.6e-03	2.2e-02	1.4e-02
3	Eye	intron excision ratio	chr6_131885909_131888095	0.27	0.19	3.5e-03	0.1	0.16	0.09	0.11	1.3e-02	2.3e-03	1.9e-02	8.8e-03
4	pVTA	gene expression	Clba1	0.31	0.17	1.6e-04	0.06	0.09	0.07	0.06	1.6e-03	7.8e-05	6.1e-04	9.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.0	0.0	0.2	0.1	-0.1	-0.2
Area under the delay curve	0.8	0.9	1.7	-1.3	-0.8	0.8	0.7
BMI with tail	1.8	5.8	6.9	-2.1	-2.6	2.6	-2.3
BMI without tail	0.5	1.1	1.5	-1.2	-1.2	1.2	-0.4
Body weight	1.1	4.6	8.1	2.9	2.3	-2.3	0.1
Weight adjusted by age	0.3	0.4	0.6	0.5	0.5	-0.6	0.8
Bone surface	0.1	0.3	0.4	-0.6	-0.5	0.4	0.4
Bone volume	0.1	0.2	0.3	-0.6	-0.4	0.3	0.5
Breakpoint value in progressive ratio session	0.4	0.4	1.5	0.1	-0.3	0.3	-1.2
Number of licking bursts	0.7	0.8	1.6	-1.3	-0.8	0.8	0.7
Context. condit. distance diff. score	3.3	4.0	4.8	2.0	2.2	-2.2	1.6
Locomotion velocity, session 1	0.1	0.1	0.2	0.4	0.4	-0.4	0.2
Locomotion distance, session 1	0.5	0.6	1.1	-0.6	-0.7	0.7	-1.1
Locomotion velocity, session 2	0.2	0.2	0.4	-0.6	-0.4	0.3	0.6
Locomotion distance, session 2	0.4	0.6	1.2	-1.1	-0.8	0.8	0.1
Locomotion velocity, session 3	0.0	0.1	0.1	-0.1	-0.2	0.2	-0.3
Locomotion distance, session 3	0.1	0.1	0.2	-0.3	-0.1	0.1	0.4
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	0.3	0.2	-0.2	0.1
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.3	0.3	-0.3	0.4
Locomotion velocity, session 7	0.3	0.3	1.1	0.4	-0.1	0.1	-1.1
Locomotion distance, session 7	0.7	0.9	1.1	-1.1	-1.0	1.0	-0.5
Stereotopy head waving bouts, day 7	1.9	2.1	2.8	1.7	1.7	-1.6	0.5
Stereotopy head waving duration, day 7	1.0	1.2	1.9	1.4	1.2	-1.2	-0.1
Locomotion velocity, session 8	1.7	2.0	3.4	1.8	1.5	-1.5	0.2
Locomotion distance, session 8	0.3	0.5	0.6	0.7	0.8	-0.8	0.4
Degree of sensitization distance	0.2	0.2	0.3	-0.3	-0.5	0.5	-0.5
Degree of sensitization stereotypy	0.7	0.7	1.2	1.1	1.0	-0.9	-0.0
Conditioned locomotion	1.4	1.6	2.1	1.4	1.4	-1.4	0.6
Cocaine response after cond. corrected	0.8	0.9	3.2	0.0	-0.5	0.5	-1.8
Cocaine response after cond. not corrected	1.7	1.8	4.8	-0.5	-1.1	1.1	-2.2
Cocaine response before conditioning	1.7	2.0	2.7	-1.6	-1.6	1.6	-0.5
Saline control response	0.0	0.0	0.0	0.2	0.1	-0.1	-0.1
Bone: connectivity density	0.3	0.5	0.7	0.9	0.8	-0.8	0.4
Bone: cortical apparent density	4.9	6.4	7.5	2.2	2.7	-2.7	2.5
Bone: cortical area	0.1	0.2	0.3	0.4	0.5	-0.5	0.5
Bone: cortical porosity	0.3	0.4	0.6	0.4	0.6	-0.6	0.8
Bone: cortical porosity	0.1	0.2	0.3	0.6	0.4	-0.4	-0.0
Bone: cortical thickness	0.3	0.6	0.9	0.9	0.8	-0.8	-0.3
Bone: cortical thickness	0.7	0.8	1.0	0.6	0.9	-0.9	1.0
Bone: cortical tissue density	5.0	6.6	7.5	2.1	2.7	-2.7	2.6
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	-0.4	-0.7	0.7	-0.9
Condit. Reinf. active-inactive response ratio	2.0	2.2	2.6	-1.1	-1.6	1.6	-1.6
Condit. Reinf. active responses	0.2	0.2	0.8	0.4	-0.0	0.1	-0.9
Condit. Reinf. inactive responses	1.5	1.8	2.4	1.4	1.6	-1.5	0.5
Incentive salience index mean	0.5	0.6	2.0	0.3	-0.3	0.4	-1.4
Condit. Reinf. lever presses	0.4	0.5	1.6	0.7	0.1	-0.1	-1.3
Condit. Reinf. active minus inactive responses	0.8	0.9	1.5	0.7	0.9	-0.9	1.2
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.7	0.2	0.6	-0.7	1.3
Condit. Reinf. active responses	0.1	0.2	0.5	0.1	0.2	-0.2	0.7
Condit. Reinf. inactive responses	0.3	0.3	0.4	-0.5	-0.6	0.6	-0.5
Condit. Reinf. lever presses	1.2	1.7	2.9	-1.7	-1.4	1.3	0.2
Condit. Reinf. lever reinforcers received	0.2	0.3	0.9	0.1	0.3	-0.3	1.0
Conditioned reinforcement - actives	1.4	1.4	1.9	0.8	1.2	-1.2	1.4
Conditioned reinforcement - inactives	0.4	0.5	0.6	0.6	0.7	-0.7	0.7
Conditioned locomotion	0.1	0.2	0.5	-0.0	-0.3	0.3	-0.7
Patch foraging indifference point 0 sec	5.2	8.3	12.6	3.5	3.2	-3.1	1.0
Patch foraging indifference point AUC	4.4	5.1	9.3	3.0	2.3	-2.2	-0.7
Delay disc. indifference point, 0s delay	0.3	0.4	0.5	0.7	0.6	-0.6	0.4
Delay disc. indifference point, 16s delay	1.0	1.0	2.0	-1.4	-0.9	0.9	0.6
Delay disc. indifference point, 2s delay	2.2	2.5	4.3	-2.1	-1.6	1.5	0.8
Delay disc. indifference point, 24s delay	0.9	0.8	1.6	-1.3	-0.9	0.9	0.3
Delay disc. indifference point, 4s delay	0.7	0.8	2.3	-0.8	-0.2	0.1	1.5
Delay disc. indifference point, 8s delay	0.3	0.3	0.6	-0.8	-0.5	0.4	0.5
Indifference point function ln k	1.1	1.5	3.5	0.6	1.0	-1.1	1.9
Indifference point function log k	1.1	1.5	3.5	0.6	1.0	-1.1	1.9
Patch foraging total patch changes 0 sec	6.1	9.9	15.1	3.9	3.5	-3.4	1.0
Patch foraging total patch changes 12 sec	3.4	4.4	5.4	2.2	2.3	-2.3	1.3
Patch foraging total patch changes 18 sec	1.9	2.4	4.1	2.0	1.7	-1.6	0.1
Patch foraging total patch changes 24 sec	1.0	1.3	2.7	1.6	1.1	-1.0	-0.4
Patch foraging total patch changes 6 sec	4.5	6.6	12.6	3.5	2.6	-2.5	-0.6
Patch foraging time to switch 0 sec	10.1	15.5	20.4	-4.5	-4.4	4.3	-2.0
Patch foraging water rate 0 sec	15.6	25.0	30.3	5.4	5.5	-5.5	3.3
Patch foraging water rate 12 sec	7.9	12.1	15.9	2.7	3.5	-3.6	4.0
Patch foraging water rate 18 sec	4.5	6.1	6.7	2.3	2.5	-2.6	2.4
Patch foraging water rate 24 sec	3.5	4.8	5.4	1.9	2.3	-2.3	2.3
Patch foraging water rate 6 sec	4.1	5.9	7.1	2.4	2.7	-2.7	1.9
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.5	0.7	0.7	-0.7	0.5
Distance traveled before self-admin	0.7	0.7	0.9	-1.0	-1.0	0.9	-0.4
Distance traveled after self-admin	0.4	0.5	1.3	0.2	0.5	-0.6	1.1
Extensor digitorum longus weight	7.9	31.2	40.1	6.3	6.2	-6.2	2.8
Bone: elastic displacement	0.5	0.6	2.1	-0.4	0.2	-0.3	1.5
Bone: elastic work	0.7	0.9	1.8	-1.2	-0.5	0.5	1.3
Bone: endosteal estimation	0.9	1.9	3.2	-1.8	-1.1	1.0	1.4
Bone: endosteal perimeter	0.1	0.2	0.4	-0.6	-0.5	0.4	0.4
Epididymis fat weight	2.5	5.9	7.0	-1.8	-2.5	2.6	-2.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	0.2	-0.2	-0.0
Delta time in open arm before/after self-admin	0.6	0.6	1.2	1.1	0.8	-0.8	-0.2
Diff in mean of infusions in LGA sessions	0.8	0.9	2.3	1.0	0.4	-0.3	-1.5
Delay discount exponential model param	0.7	0.7	1.4	1.2	0.7	-0.7	-0.8
Extinction: sum of active levers before priming	0.2	0.2	0.6	-0.0	-0.3	0.3	-0.8
Active lever presses in extinction session 6	1.3	1.2	1.6	1.1	1.2	-1.3	0.8
Bone: final force	0.4	0.6	2.2	-0.5	-0.0	-0.1	1.5
Bone: final moment	0.3	0.6	2.1	-0.3	0.2	-0.2	1.4
Food consumed during 24 hour testing period	0.7	0.9	1.3	1.1	1.0	-1.0	0.3
Glucose	0.2	0.4	1.2	-0.1	0.3	-0.4	1.1
Heart weight	0.1	0.1	0.3	-0.4	-0.2	0.2	0.5
Delay discount hyperbolic model param	0.9	0.9	1.7	1.3	0.9	-0.8	-0.8
Intermittent access intake day 1-15 change	1.5	1.5	1.8	-1.2	-1.3	1.3	-1.0
Intermittent access intake escalation	1.5	1.5	1.7	-1.2	-1.3	1.3	-1.0
Intermittent access intake escalation 2	0.3	0.3	0.6	-0.4	-0.6	0.6	-0.8
Intermitt. access day 1 inactive lever presses	2.7	2.9	3.6	1.7	1.9	-1.9	1.3
Intermitt. access day 15 inactive lever presses	0.8	0.9	1.7	0.5	0.9	-0.9	1.3
Intermitt. access escalation Index	0.2	0.2	0.5	0.0	0.3	-0.3	0.7
Intermittent access day 1 total infusions	0.2	0.2	0.6	0.3	0.0	0.0	-0.8
Intermittent access day 15 total infusions	1.1	1.3	1.4	-1.0	-1.2	1.2	-1.2
Intermittent access terminal intake (last 3 days)	1.5	1.6	1.8	-1.1	-1.3	1.4	-1.2
Intermittent access total infusions	0.2	0.3	0.6	-0.2	-0.4	0.5	-0.8
Intermittent access day 1 locomotion	0.2	0.2	0.7	-0.0	-0.3	0.3	-0.8
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.1
Intermittent access total locomotion	0.1	0.1	0.5	0.3	-0.0	0.1	-0.7
Intermittent access standard deviation	2.3	2.4	5.7	-0.6	-1.3	1.3	-2.4
Left kidney weight	2.4	6.7	8.9	3.0	2.9	-2.8	1.2
Right kidney weight	1.3	3.7	4.6	2.0	2.1	-2.1	1.3
Cocaine induced anxiety	0.9	1.0	2.0	0.5	0.9	-1.0	1.4
Post-drug Anxiety	0.5	0.6	0.8	0.6	0.8	-0.8	0.9
Baseline Anxiety	1.0	1.1	1.5	-0.8	-1.1	1.1	-1.2
Tail length	4.4	13.3	16.4	3.9	4.0	-4.0	2.3
Length with tail	7.5	27.3	36.1	6.0	5.8	-5.8	2.4
Length without tail	4.3	9.5	14.5	3.8	3.4	-3.4	0.7
Times rat made contact with spout	0.1	0.1	0.3	0.5	0.4	-0.3	-0.2
Lifetime Intake	0.1	0.1	0.1	-0.4	-0.3	0.3	-0.1
Liver weight, left	2.1	3.4	4.6	2.1	2.1	-2.0	0.9
Liver weight, right	0.4	0.6	1.1	1.1	0.6	-0.6	-0.9
Locomotor activity	0.2	0.2	0.3	0.4	0.5	-0.5	0.6
Locomotor testing distance	0.2	0.4	0.9	0.3	0.5	-0.5	0.9
Locomotor testing rearing	1.8	2.7	3.4	-1.7	-1.8	1.8	-1.1
Locomotion in novel chamber	4.6	5.7	8.3	1.6	2.4	-2.5	2.9
Locomotion in novel chamber post-restriction	0.1	0.2	0.3	-0.5	-0.3	0.2	0.5
Fecal boli incidents, locomotor time 1	1.7	1.9	5.1	-0.4	-1.0	1.1	-2.3
Change in fecal boli incidents, locomotor task	2.5	2.4	2.8	1.4	1.5	-1.6	1.7
Time >=10cm from walls, locomotor time 1	2.3	2.3	4.2	1.9	0.9	-0.8	-2.1
Bouts of movement, locomotor time 1	1.5	1.6	1.8	-1.2	-1.3	1.3	-1.2
Total resting periods, locomotor time 1	1.5	1.6	1.9	-1.3	-1.4	1.4	-1.0
Rest time, locomotor task time 1	0.3	0.3	0.5	-0.7	-0.5	0.4	0.6
Distance moved, locomotor task time 1	0.6	0.7	1.4	-1.2	-0.8	0.8	0.2
Vertical activity count, locomotor time 1	0.2	0.2	0.7	-0.4	0.0	-0.1	0.9
Time >=10cm from walls, locomotor time 2	1.7	1.8	3.6	1.9	1.3	-1.2	-0.8
Bouts of movement, locomotor time 2	1.6	1.7	5.9	-0.3	0.6	-0.7	2.4
Total resting periods, locomotor time 2	1.4	1.5	5.3	-0.4	0.4	-0.5	2.3
Rest time, locomotor task time 2	0.2	0.2	0.8	-0.4	-0.0	-0.0	0.9
Distance moved, locomotor task time 2	0.3	0.4	0.5	-0.7	-0.7	0.7	-0.4
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.1	0.2	-0.2	0.1
Light reinforcement 1	0.0	0.0	0.0	0.2	0.1	-0.1	0.2
Light reinforcement 2	1.6	2.2	2.5	-1.2	-1.5	1.5	-1.6
Bone: marrow area	0.9	1.9	3.2	-1.8	-1.1	1.0	1.5
Bone: maximum diameter	0.1	0.3	0.3	-0.6	-0.6	0.6	-0.3
Bone: maximum force	0.2	0.3	1.0	-0.0	0.2	-0.2	1.0
Bone: maximum moment	0.1	0.2	0.7	0.2	0.3	-0.4	0.8
Mean time between licks in bursts	0.4	0.6	0.9	-1.0	-0.9	0.8	-0.3
Mean num. licks in bursts	1.0	1.1	2.2	1.5	1.0	-0.9	-0.7
Cd content in liver	1.8	1.9	4.0	0.7	1.2	-1.3	2.0
Co content in liver	1.0	1.2	1.5	0.9	1.2	-1.2	1.1
Cu content in liver	2.2	2.7	3.2	-1.7	-1.8	1.8	-1.0
Fe content in liver	0.7	0.8	1.2	-1.1	-1.0	1.0	-0.2
K content in liver	0.6	0.6	1.0	1.0	0.7	-0.7	-0.6
Mg content in liver	0.1	0.1	0.2	0.4	0.4	-0.4	0.2
Mn content in liver	0.5	0.5	1.1	0.4	0.6	-0.7	1.0
Na content in liver	0.5	0.5	1.8	-0.0	-0.4	0.4	-1.4
Rb content in liver	0.8	1.0	2.4	0.3	0.9	-0.9	1.6
Se content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.2
Sr content in liver	0.6	0.6	1.9	-0.6	0.2	-0.2	1.4
Zn content in liver	0.2	0.2	0.6	-0.4	0.0	-0.1	0.8
Bone: minimum diameter	0.7	1.3	1.9	0.9	1.1	-1.1	1.4
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.2	-0.1	0.1	-0.1
Time in novel zone, hab. session 1	0.5	0.5	0.8	-0.9	-0.8	0.8	0.1
Total zone transitions, hab. session 1	0.3	0.5	0.8	-0.9	-0.6	0.6	0.5
Total locomotion distance, hab. session 1	0.6	0.8	2.8	-0.0	0.5	-0.5	1.7
Locomotion velocity, hab. session 1	0.8	1.2	2.4	0.6	1.0	-1.0	1.6
Time in familiar zone, hab. session 2	0.6	0.6	1.7	0.7	0.3	-0.2	-1.3
Time in novel zone, hab. session 2	0.6	0.6	1.1	-1.0	-0.7	0.7	0.6
Total zone transitions, hab. session 2	0.4	0.5	1.0	-0.5	-0.6	0.7	-1.0
Total locomotion distance, hab. session 2	0.3	0.4	0.6	0.3	0.6	-0.6	0.8
Locomotion velocity, hab. session 2	0.4	0.5	0.7	0.5	0.8	-0.8	0.8
Novel to familiar place preference ratio	0.7	0.8	1.2	-1.1	-0.9	0.9	-0.4
Novelty place preference	0.7	0.7	1.4	-1.2	-0.9	0.9	0.0
Time in novel zone, NPP test	0.3	0.3	0.5	-0.7	-0.6	0.6	-0.1
Total zone transitions, NPP test	0.3	0.4	0.6	0.8	0.7	-0.7	-0.0
Total locomotion distance, NPP test	0.3	0.5	0.6	0.6	0.8	-0.8	0.6
Locomotion velocity, NPP test	0.3	0.4	0.6	0.4	0.6	-0.7	0.8
Intraocular pressure	0.2	0.3	0.4	-0.7	-0.4	0.4	0.5
Delta distance traveled before/after self-admin	0.6	0.6	0.8	0.6	0.8	-0.8	0.9
Delta ambulatory time before/after self-admin	1.6	1.8	2.5	1.0	1.3	-1.4	1.6
Parametrial fat weight	0.1	0.1	0.3	-0.6	-0.4	0.4	0.0
Pavlov. Cond. lever latency	0.6	0.7	2.4	-0.2	0.5	-0.6	1.5
Pavlov. Cond. magazine entry latency	0.4	0.5	1.5	0.0	-0.4	0.4	-1.2
Pavlov. Cond. change in total contacts	0.2	0.3	0.9	0.3	-0.2	0.2	-1.0
Pavlov. Cond. index score	0.7	0.9	3.0	0.1	-0.6	0.6	-1.7
Pavlov. Cond. latency score	0.6	0.7	2.3	0.1	-0.5	0.5	-1.5
Pavlov. Cond. lever contacts	0.9	1.1	2.6	-0.3	-0.9	0.9	-1.6
Pavlov. Cond. magazine entry number	0.6	0.7	2.6	-0.3	0.4	-0.4	1.6
Pavlov. Cond. intertrial magazine entries	6.6	7.9	10.3	3.2	3.2	-3.1	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	2.6	0.1	-0.5	0.6	-1.6
Pavlov. Cond. response bias	0.9	1.0	3.7	0.3	-0.4	0.5	-1.9
Pavlov. Cond. lever latency	2.0	2.7	4.5	2.1	1.8	-1.7	-0.1
Pavlov. Cond. magazine entry latency	3.1	3.6	4.5	-2.1	-2.1	2.1	-1.2
Pavlov. Cond. change in total contacts	4.5	6.2	8.8	-3.0	-2.8	2.7	-0.8
Pavlov. Cond. index score	3.5	4.5	6.3	-2.5	-2.4	2.3	-0.7
Pavlov. Cond. latency score	3.4	4.2	5.4	-2.3	-2.3	2.3	-1.0
Pavlov. Cond. lever contacts	2.4	3.3	5.1	-2.3	-2.0	2.0	-0.4
Pavlov. Cond. magazine entry number	2.6	3.2	4.3	2.1	2.0	-2.0	0.8
Pavlov. Cond. intertrial magazine entries	4.5	5.9	7.0	2.5	2.6	-2.7	1.9
Pavlov. Cond. lever-magazine prob. diff.	4.1	5.3	7.2	-2.7	-2.6	2.5	-0.9
Pavlov. Cond. response bias	2.5	3.4	4.9	-2.2	-2.1	2.0	-0.5
Time in closed arm before self-admin	5.7	6.4	9.8	-3.1	-2.8	2.8	-0.6
Time in closed arm after self-admin	4.1	4.2	7.8	-2.8	-2.1	2.0	0.9
Time in open arm before self-admin	5.6	6.1	7.5	2.5	2.7	-2.7	1.7
Time in open arm after self-admin	6.9	7.6	12.8	3.6	3.0	-2.9	-0.0
Bone: periosteal estimation	0.4	0.7	1.8	-0.9	-0.4	0.3	1.3
Bone: periosteal perimeter	0.0	0.0	0.0	-0.0	-0.1	0.1	0.0
Bone: post-yield work	2.0	2.8	3.3	1.8	1.8	-1.8	1.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.3	-0.1	0.1	0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.4	-0.3	0.2	0.2
Progressive ratio test 1 inactive lever presses	2.7	2.9	3.3	1.5	1.8	-1.8	1.7
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.2	-0.1	0.1	0.3
Progressive ratio test 2 breakpoint	0.0	0.0	0.2	-0.1	0.1	-0.1	0.4
Progressive ratio test 2 inactive lever presses	0.6	0.7	2.2	-0.0	0.4	-0.5	1.5
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.4	-0.2	0.2	0.5
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	-0.4	-0.1	0.1	0.7
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.3	-0.5	-0.7	0.8	-1.1
Progressive ratio	1.4	1.7	3.7	-1.5	-0.6	0.5	1.9
Food seeking constrained by brief footshock	0.4	0.5	1.5	0.0	0.4	-0.4	1.2
Seeking ratio, punishment vs. effort	0.6	0.8	1.5	1.2	0.8	-0.7	-0.7
Retroperitoneal fat weight	0.1	0.4	1.0	-0.2	-0.6	0.6	-1.0
Reaction time number correct	3.5	5.1	6.6	2.6	2.5	-2.5	1.2
Reaction time mean minus median	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.1
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.2	-0.1	0.1	0.3
Reaction time num false alarms	1.4	1.9	3.0	1.7	1.5	-1.5	0.4
Reaction time num false alarms AUC	1.7	2.3	3.3	1.8	1.7	-1.7	0.7
Reaction time trials correct on left	3.5	5.1	6.6	2.6	2.5	-2.5	1.2
Reaction time trials on left	3.6	5.2	6.6	2.6	2.5	-2.5	1.3
Reaction time mean	1.3	1.9	3.5	-1.9	-1.4	1.4	0.3
Reaction time mean AUC	0.8	1.1	2.2	-1.5	-1.0	1.0	0.4
Median of all reaction times	1.2	1.6	3.1	-1.8	-1.2	1.1	0.7
Reaction time omissions	1.4	1.9	2.6	1.0	1.4	-1.4	1.6
Reaction time false alarm rate	0.1	0.1	0.2	0.5	0.4	-0.4	0.2
Reaction time premature initiation rate	0.3	0.5	0.9	0.3	0.6	-0.6	0.9
Reaction time premature initiations	2.0	2.8	3.3	1.7	1.8	-1.8	1.2
Std. dev. reaction times	0.8	1.2	2.3	-1.5	-1.1	1.0	0.5
Reaction time trials completed	3.6	5.2	6.6	2.6	2.5	-2.5	1.3
Reaction time trials AUC	3.7	5.4	7.0	2.6	2.6	-2.5	1.3
Run reversals in cocaine runway, females	2.2	2.1	3.3	-1.8	-1.6	1.6	-0.3
Run reversals in cocaine runway, males	0.1	0.1	0.4	-0.1	0.0	-0.1	0.6
Latency to leave start box in cocaine runway	0.6	0.6	1.0	-1.0	-0.9	0.9	-0.0
Latency to leave start box in cocaine runway, F	0.5	0.5	0.8	-0.5	-0.7	0.8	-0.9
Latency to leave start box in cocaine runway, M	0.5	0.5	0.8	-0.9	-0.8	0.7	0.1
Std. dev. time between licks in bursts	0.0	0.1	0.1	0.3	0.2	-0.2	0.0
Total sessions with >9 infusions	0.0	0.0	0.0	-0.2	-0.1	0.1	0.2
Short access day 1 total inactive lever presses	0.1	0.1	0.4	-0.2	0.0	-0.0	0.6
Short access day 10 total inactive lever presses	0.7	0.8	2.0	0.3	0.7	-0.8	1.4
Short access day 1 total infusions	0.3	0.3	1.0	-0.1	0.2	-0.3	1.0
Short access day 10 total infusions	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.1
Short access total infusions	0.4	0.5	0.8	-0.9	-0.7	0.6	0.4
Short access day 1 locomotion	0.3	0.3	0.5	-0.7	-0.6	0.6	-0.2
Short access day 10 total locomotion	0.3	0.3	0.9	0.1	-0.3	0.3	-1.0
Short access total locomotion	0.0	0.0	0.0	-0.1	-0.1	0.1	0.0
One hour access (0.3 mA shock)	0.3	0.3	0.6	0.8	0.6	-0.6	-0.2
Compulsive drug intake	0.5	0.5	0.9	0.9	0.5	-0.5	-0.8
One hour access (shock baseline)	0.1	0.1	0.2	-0.4	-0.3	0.3	0.1
Social response proportion	0.6	0.7	2.1	-0.8	-0.2	0.1	1.4
Social responses	0.3	0.4	0.6	-0.8	-0.5	0.5	0.7
Social time	1.7	2.2	7.6	-0.2	0.7	-0.8	2.8
Soleus weight	1.3	3.9	7.2	2.7	1.8	-1.7	-1.4
Bone: stiffness	1.1	1.7	2.0	1.2	1.4	-1.4	1.2
Tibialis anterior weight	0.6	1.9	2.8	1.7	1.6	-1.5	0.1
Time to tail flick, vehicle, before self-admin	1.4	1.5	2.5	1.6	1.3	-1.3	-0.2
Time to tail flick, vehicle, after self-admin	0.6	0.6	1.1	1.1	0.7	-0.7	-0.6
Time to tail flick, test, before self-admin	0.1	0.1	0.3	-0.4	-0.1	0.1	0.6
Time to tail flick, test, after self-admin	3.4	3.5	5.8	2.4	2.1	-2.0	0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.5	0.3	-0.3	-0.3
Delta time to tail flick, test, before/after SA	3.6	3.2	5.7	2.4	1.9	-1.9	0.0
Tibia length	0.1	0.3	0.5	0.7	0.5	-0.5	0.2
Ambulatory time before self-admin	1.1	1.1	1.3	-1.0	-1.2	1.2	-0.8
Ambulatory time after self-admin	0.1	0.1	0.2	-0.4	-0.3	0.2	0.3
Bone: tissue strength	0.1	0.1	0.2	-0.5	-0.4	0.3	0.3
Total heroin consumption	1.6	1.8	3.7	1.9	1.3	-1.2	-0.8
Bone: trabecular number	0.2	0.4	0.5	0.7	0.7	-0.7	0.4
Bone: trabecular spacing	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.3
Bone: trabecular thickness	0.0	0.1	0.1	0.3	0.3	-0.3	0.1
Bone: trabecular tissue density	0.0	0.0	0.1	-0.1	-0.0	0.1	-0.3
Water consumed over 24 hours	2.0	2.4	3.5	1.2	1.5	-1.6	1.9
Number of responses in last shaping day	0.5	0.5	0.8	-0.9	-0.8	0.8	-0.1