Hub : Genes

Clba1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	intron excision ratio	chr6_137706990_137709176	0.28	0.19	2.4e-03	0.2	0.17	0.14	0.08	5.8e-04	1.2e-03	3.5e-03	2.5e-02
2	Eye	intron excision ratio	chr6_137707688_137709176	0.25	0.17	3.2e-03	0.22	0.16	0.14	0.05	2.3e-04	1.8e-03	4.1e-03	6.5e-02
3	Eye	mRNA stability	Clba1	0.2	0.15	1.0e-02	0.12	0.09	0.07	0.02	6.0e-03	1.8e-02	3.5e-02	1.4e-01
4	Brain	gene expression	Clba1	0.02	0.02	9.3e-03	0.01	0.01	0	0.01	5.3e-02	3.0e-02	1.1e-01	6.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.1
Area under the delay curve	0.6	0.6	0.7	0.8	-0.8	0.8	0.9
BMI with tail	2.0	7.0	10.3	2.4	-2.4	2.4	3.2
BMI without tail	1.0	2.9	5.6	1.4	-1.4	1.4	2.4
Body weight	1.6	6.9	7.9	-2.8	2.8	-2.8	-2.0
Weight adjusted by age	0.5	0.8	0.9	-0.9	0.9	-0.9	-0.7
Bone surface	0.0	0.1	0.2	0.3	-0.3	0.3	0.4
Bone volume	0.0	0.1	0.1	0.3	-0.3	0.3	0.3
Breakpoint value in progressive ratio session	0.1	0.1	0.1	-0.4	0.4	-0.4	-0.2
Number of licking bursts	0.5	0.9	0.9	1.0	-1.0	1.0	0.8
Context. condit. distance diff. score	3.5	4.3	4.7	-2.0	2.0	-2.0	-2.2
Locomotion velocity, session 1	0.2	0.2	0.2	-0.5	0.5	-0.5	-0.4
Locomotion distance, session 1	0.2	0.2	0.6	0.3	-0.3	0.3	0.8
Locomotion velocity, session 2	0.2	0.2	0.3	0.5	-0.5	0.5	0.3
Locomotion distance, session 2	0.5	0.7	0.7	0.8	-0.8	0.8	0.8
Locomotion velocity, session 3	0.1	0.1	0.1	0.3	-0.3	0.3	0.3
Locomotion distance, session 3	0.2	0.3	0.3	0.6	-0.6	0.6	0.2
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.2
Stereotopy head waving duration, day 3	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.4
Locomotion velocity, session 7	0.1	0.1	0.1	-0.3	0.3	-0.3	0.2
Locomotion distance, session 7	0.5	0.7	1.0	0.7	-0.7	0.7	1.0
Stereotopy head waving bouts, day 7	2.1	2.4	2.6	-1.6	1.6	-1.6	-1.4
Stereotopy head waving duration, day 7	1.1	1.3	1.3	-1.2	1.2	-1.2	-1.1
Locomotion velocity, session 8	1.7	2.1	2.1	-1.4	1.4	-1.4	-1.4
Locomotion distance, session 8	0.3	0.5	0.5	-0.7	0.7	-0.7	-0.7
Degree of sensitization distance	0.1	0.1	0.2	-0.2	0.2	-0.2	0.5
Degree of sensitization stereotypy	0.9	0.9	1.0	-1.0	1.0	-1.0	-0.9
Conditioned locomotion	1.9	2.2	2.3	-1.5	1.5	-1.5	-1.4
Cocaine response after cond. corrected	0.1	0.1	0.4	-0.0	0.0	-0.0	0.6
Cocaine response after cond. not corrected	0.7	0.8	1.5	0.8	-0.8	0.8	1.2
Cocaine response before conditioning	3.4	4.0	4.5	2.1	-2.1	2.1	1.6
Saline control response	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.3
Bone: connectivity density	0.4	0.7	0.7	-0.8	0.8	-0.8	-0.8
Bone: cortical apparent density	5.3	7.2	7.8	-2.6	2.6	-2.6	-2.8
Bone: cortical area	0.2	0.3	0.4	-0.6	0.6	-0.6	-0.4
Bone: cortical porosity	0.3	0.4	0.8	-0.4	0.4	-0.4	-0.9
Bone: cortical porosity	0.0	0.1	0.1	0.1	-0.1	0.1	-0.4
Bone: cortical thickness	0.8	1.4	1.6	-1.3	1.3	-1.3	-0.8
Bone: cortical thickness	0.8	0.9	0.9	-1.0	1.0	-1.0	-0.9
Bone: cortical tissue density	5.1	6.9	7.6	-2.6	2.6	-2.6	-2.8
Condit. Reinf. active minus inactive responses	0.1	0.2	0.6	0.1	-0.1	0.1	0.8
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.6	1.1	-1.1	1.1	1.6
Condit. Reinf. active responses	0.2	0.2	0.3	-0.5	0.5	-0.5	0.2
Condit. Reinf. inactive responses	1.9	2.3	2.4	-1.5	1.5	-1.5	-1.5
Incentive salience index mean	0.1	0.1	0.2	-0.3	0.3	-0.3	0.5
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.0
Condit. Reinf. active minus inactive responses	0.6	0.8	0.8	-0.9	0.9	-0.9	-0.9
Condit. Reinf. active-inactive response ratio	0.7	0.8	0.9	-0.9	0.9	-0.9	-0.7
Condit. Reinf. active responses	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1
Condit. Reinf. inactive responses	0.9	1.1	1.3	1.1	-1.1	1.1	0.8
Condit. Reinf. lever presses	2.5	3.5	3.9	2.0	-2.0	2.0	1.5
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.2
Conditioned reinforcement - actives	0.1	0.2	0.3	-0.4	0.4	-0.4	-0.6
Conditioned reinforcement - inactives	0.4	0.6	0.7	-0.8	0.8	-0.8	-0.6
Conditioned locomotion	0.0	0.0	0.0	-0.0	0.0	-0.0	0.1
Patch foraging indifference point 0 sec	5.7	10.6	10.9	-3.3	3.3	-3.3	-3.1
Patch foraging indifference point AUC	3.7	5.3	5.7	-2.4	2.4	-2.4	-2.0
Delay disc. indifference point, 0s delay	0.4	0.4	0.5	-0.7	0.7	-0.7	-0.5
Delay disc. indifference point, 16s delay	1.1	1.2	1.2	1.1	-1.1	1.1	1.0
Delay disc. indifference point, 2s delay	2.2	2.4	2.5	1.6	-1.6	1.6	1.5
Delay disc. indifference point, 24s delay	0.8	0.9	1.0	0.9	-0.9	0.9	1.0
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.3	-0.3	0.3	0.0
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	0.4	-0.4	0.4	0.5
Indifference point function ln k	0.4	0.7	1.2	-0.7	0.7	-0.7	-1.1
Indifference point function log k	0.4	0.7	1.2	-0.7	0.7	-0.7	-1.1
Patch foraging total patch changes 0 sec	6.4	12.1	12.4	-3.5	3.5	-3.5	-3.4
Patch foraging total patch changes 12 sec	3.5	4.5	5.0	-2.1	2.1	-2.1	-2.2
Patch foraging total patch changes 18 sec	2.0	3.1	3.4	-1.9	1.9	-1.9	-1.5
Patch foraging total patch changes 24 sec	0.5	0.8	0.9	-0.9	0.9	-0.9	-1.0
Patch foraging total patch changes 6 sec	4.3	6.6	6.8	-2.6	2.6	-2.6	-2.4
Patch foraging time to switch 0 sec	10.1	20.6	21.7	4.7	-4.7	4.7	4.2
Patch foraging water rate 0 sec	14.9	31.3	31.9	-5.7	5.7	-5.7	-5.4
Patch foraging water rate 12 sec	5.9	12.4	13.5	-3.5	3.5	-3.5	-3.7
Patch foraging water rate 18 sec	3.7	5.8	6.5	-2.4	2.4	-2.4	-2.6
Patch foraging water rate 24 sec	3.0	4.2	5.0	-2.0	2.0	-2.0	-2.2
Patch foraging water rate 6 sec	4.5	6.6	6.7	-2.6	2.6	-2.6	-2.6
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.4	-0.5	0.5	-0.5	-0.6
Distance traveled before self-admin	0.5	0.7	0.7	0.8	-0.8	0.8	0.8
Distance traveled after self-admin	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.5
Extensor digitorum longus weight	8.9	35.2	35.4	-5.9	5.9	-5.9	-6.0
Bone: elastic displacement	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.3
Bone: elastic work	0.2	0.2	0.3	0.5	-0.5	0.5	0.3
Bone: endosteal estimation	1.0	2.2	2.6	1.6	-1.6	1.6	1.1
Bone: endosteal perimeter	0.2	0.5	0.6	0.8	-0.8	0.8	0.6
Epididymis fat weight	1.9	6.4	9.5	2.3	-2.3	2.3	3.1
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.2	-0.2	0.2	-0.2
Delta time in open arm before/after self-admin	1.3	1.2	1.5	-1.2	1.2	-1.2	-0.8
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	-0.4	0.4	-0.4	-0.3
Delay discount exponential model param	0.5	0.6	0.7	-0.7	0.7	-0.7	-0.8
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.2	0.2	-0.2	0.5
Active lever presses in extinction session 6	1.9	1.9	1.9	-1.4	1.4	-1.4	-1.4
Bone: final force	0.2	0.2	0.3	0.6	-0.6	0.6	0.0
Bone: final moment	0.1	0.1	0.1	0.3	-0.3	0.3	-0.1
Food consumed during 24 hour testing period	0.8	1.1	1.2	-1.1	1.1	-1.1	-0.9
Glucose	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.4
Heart weight	0.6	1.0	1.0	-1.0	1.0	-1.0	-0.8
Delay discount hyperbolic model param	0.6	0.6	0.7	-0.8	0.8	-0.8	-0.8
Intermittent access intake day 1-15 change	1.5	3.1	3.6	1.7	-1.7	1.7	1.9
Intermittent access intake escalation	1.4	2.9	3.8	1.6	-1.6	1.6	1.9
Intermittent access intake escalation 2	0.8	0.9	1.6	0.8	-0.8	0.8	1.3
Intermitt. access day 1 inactive lever presses	0.3	1.3	1.5	-1.2	1.2	-1.2	-0.9
Intermitt. access day 15 inactive lever presses	2.1	4.3	4.8	-2.2	2.2	-2.2	-1.7
Intermitt. access escalation Index	0.2	0.3	0.9	-0.4	0.4	-0.4	-1.0
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.3	-0.3	0.3	0.4
Intermittent access day 15 total infusions	1.1	1.6	2.0	1.2	-1.2	1.2	1.4
Intermittent access terminal intake (last 3 days)	1.3	1.7	2.5	1.2	-1.2	1.2	1.6
Intermittent access total infusions	0.4	0.5	0.7	0.6	-0.6	0.6	0.8
Intermittent access day 1 locomotion	0.7	0.9	1.1	0.9	-0.9	0.9	1.1
Intermittent access day 15 total locomotion	0.7	1.2	1.4	1.2	-1.2	1.2	0.9
Intermittent access total locomotion	0.3	0.3	0.5	0.5	-0.5	0.5	0.7
Intermittent access standard deviation	0.3	0.7	1.4	0.6	-0.6	0.6	1.2
Left kidney weight	1.9	8.8	11.6	-2.8	2.8	-2.8	-3.4
Right kidney weight	1.4	6.3	8.5	-2.4	2.4	-2.4	-2.9
Cocaine induced anxiety	0.6	0.9	1.3	-0.9	0.9	-0.9	-1.1
Post-drug Anxiety	1.8	1.9	2.6	-1.3	1.3	-1.3	-1.6
Baseline Anxiety	0.1	0.1	0.1	0.3	-0.3	0.3	0.3
Tail length	6.2	24.3	25.2	-5.0	5.0	-5.0	-4.6
Length with tail	9.7	42.4	43.2	-6.6	6.6	-6.6	-6.3
Length without tail	4.9	15.8	16.6	-3.9	3.9	-3.9	-4.1
Times rat made contact with spout	0.5	0.6	0.7	-0.8	0.8	-0.8	-0.3
Lifetime Intake	0.3	0.4	0.5	0.6	-0.6	0.6	0.7
Liver weight, left	3.0	5.0	5.5	-2.2	2.2	-2.2	-2.3
Liver weight, right	0.0	0.0	0.1	0.2	-0.2	0.2	0.1
Locomotor activity	0.1	0.1	0.3	-0.1	0.1	-0.1	-0.6
Locomotor testing distance	0.0	0.1	0.3	-0.0	0.0	-0.0	-0.5
Locomotor testing rearing	2.3	4.6	4.8	2.2	-2.2	2.2	2.0
Locomotion in novel chamber	2.8	3.6	3.8	-1.9	1.9	-1.9	-2.0
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	0.3	-0.3	0.3	0.2
Fecal boli incidents, locomotor time 1	0.3	0.5	1.2	0.5	-0.5	0.5	1.1
Change in fecal boli incidents, locomotor task	0.7	0.7	1.6	-0.6	0.6	-0.6	-1.3
Time >=10cm from walls, locomotor time 1	0.6	0.6	0.6	-0.8	0.8	-0.8	-0.6
Bouts of movement, locomotor time 1	1.0	1.1	2.0	0.9	-0.9	0.9	1.4
Total resting periods, locomotor time 1	1.2	1.3	2.2	1.0	-1.0	1.0	1.5
Rest time, locomotor task time 1	0.2	0.3	0.3	0.5	-0.5	0.5	0.6
Distance moved, locomotor task time 1	0.4	0.5	0.6	0.8	-0.8	0.8	0.5
Vertical activity count, locomotor time 1	0.0	0.1	0.1	0.2	-0.2	0.2	-0.4
Time >=10cm from walls, locomotor time 2	1.1	1.6	1.7	-1.3	1.3	-1.3	-1.1
Bouts of movement, locomotor time 2	0.2	0.3	0.5	-0.4	0.4	-0.4	-0.7
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.2	0.2	-0.2	-0.5
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.0	0.0	-0.0	0.0
Distance moved, locomotor task time 2	0.3	0.4	0.4	0.7	-0.7	0.7	0.5
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.2	0.2	-0.2	-0.5
Light reinforcement 1	0.1	0.2	0.2	0.5	-0.5	0.5	-0.2
Light reinforcement 2	1.5	2.3	2.4	1.5	-1.5	1.5	1.5
Bone: marrow area	1.0	2.1	2.4	1.5	-1.5	1.5	1.1
Bone: maximum diameter	0.1	0.3	0.5	0.4	-0.4	0.4	0.7
Bone: maximum force	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1
Bone: maximum moment	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.2
Mean time between licks in bursts	0.4	1.0	1.1	1.1	-1.1	1.1	0.7
Mean num. licks in bursts	1.1	1.7	2.0	-1.4	1.4	-1.4	-0.9
Cd content in liver	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.2
Co content in liver	1.8	2.1	2.4	-1.5	1.5	-1.5	-1.1
Cu content in liver	1.6	1.9	2.0	1.4	-1.4	1.4	1.4
Fe content in liver	0.7	0.8	0.9	0.9	-0.9	0.9	0.8
K content in liver	0.4	0.4	0.5	-0.6	0.6	-0.6	-0.7
Mg content in liver	0.1	0.1	0.2	0.0	-0.0	0.0	-0.5
Mn content in liver	0.2	0.2	0.3	0.6	-0.6	0.6	-0.1
Na content in liver	0.9	0.9	1.0	1.0	-1.0	1.0	0.8
Rb content in liver	0.2	0.2	0.7	-0.2	0.2	-0.2	-0.8
Se content in liver	0.2	0.2	0.2	0.5	-0.5	0.5	0.3
Sr content in liver	0.0	0.0	0.0	0.1	-0.1	0.1	0.0
Zn content in liver	0.5	0.6	0.6	-0.8	0.8	-0.8	-0.7
Bone: minimum diameter	0.4	0.8	1.1	-0.9	0.9	-0.9	-1.0
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1
Time in novel zone, hab. session 1	1.0	1.0	1.2	1.1	-1.1	1.1	0.7
Total zone transitions, hab. session 1	0.8	1.1	1.3	1.1	-1.1	1.1	0.6
Total locomotion distance, hab. session 1	0.1	0.1	0.4	0.2	-0.2	0.2	-0.6
Locomotion velocity, hab. session 1	0.3	0.4	1.1	-0.4	0.4	-0.4	-1.0
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.4	0.4	-0.4	-0.1
Time in novel zone, hab. session 2	0.7	0.7	0.7	0.9	-0.9	0.9	0.7
Total zone transitions, hab. session 2	0.1	0.1	0.6	0.0	-0.0	0.0	0.8
Total locomotion distance, hab. session 2	0.4	0.5	0.5	-0.7	0.7	-0.7	-0.6
Locomotion velocity, hab. session 2	0.5	0.7	0.8	-0.9	0.9	-0.9	-0.7
Novel to familiar place preference ratio	0.7	0.7	0.9	0.8	-0.8	0.8	1.0
Novelty place preference	0.6	0.6	0.8	0.8	-0.8	0.8	0.9
Time in novel zone, NPP test	0.2	0.3	0.3	0.5	-0.5	0.5	0.6
Total zone transitions, NPP test	0.6	0.8	1.0	-1.0	1.0	-1.0	-0.6
Total locomotion distance, NPP test	0.4	0.5	0.6	-0.7	0.7	-0.7	-0.7
Locomotion velocity, NPP test	0.4	0.6	0.7	-0.8	0.8	-0.8	-0.6
Intraocular pressure	0.0	0.0	0.1	-0.0	0.0	-0.0	0.3
Delta distance traveled before/after self-admin	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.3
Delta ambulatory time before/after self-admin	0.8	0.9	1.0	-1.0	1.0	-1.0	-1.0
Parametrial fat weight	0.0	0.1	0.1	0.4	-0.4	0.4	0.2
Pavlov. Cond. lever latency	0.1	0.2	0.5	-0.2	0.2	-0.2	-0.7
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.0	-0.0	0.0	0.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.0	0.0	-0.0	0.3
Pavlov. Cond. index score	0.1	0.1	0.4	0.1	-0.1	0.1	0.6
Pavlov. Cond. latency score	0.1	0.1	0.3	0.1	-0.1	0.1	0.6
Pavlov. Cond. lever contacts	0.5	0.6	1.1	0.7	-0.7	0.7	1.0
Pavlov. Cond. magazine entry number	0.0	0.1	0.2	-0.0	0.0	-0.0	-0.4
Pavlov. Cond. intertrial magazine entries	8.5	10.1	10.6	-3.3	3.3	-3.3	-3.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	0.1	-0.1	0.1	0.6
Pavlov. Cond. response bias	0.1	0.1	0.4	0.0	-0.0	0.0	0.6
Pavlov. Cond. lever latency	2.9	4.0	4.3	-2.1	2.1	-2.1	-1.8
Pavlov. Cond. magazine entry latency	3.2	3.9	4.5	1.9	-1.9	1.9	2.1
Pavlov. Cond. change in total contacts	4.5	7.2	7.4	2.7	-2.7	2.7	2.7
Pavlov. Cond. index score	4.4	5.9	6.0	2.4	-2.4	2.4	2.4
Pavlov. Cond. latency score	4.3	5.7	5.7	2.4	-2.4	2.4	2.4
Pavlov. Cond. lever contacts	3.5	4.8	5.0	2.2	-2.2	2.2	2.0
Pavlov. Cond. magazine entry number	2.9	3.6	4.3	-1.8	1.8	-1.8	-2.1
Pavlov. Cond. intertrial magazine entries	4.6	6.9	7.2	-2.6	2.6	-2.6	-2.7
Pavlov. Cond. lever-magazine prob. diff.	5.1	6.8	6.9	2.6	-2.6	2.6	2.5
Pavlov. Cond. response bias	3.2	4.4	4.4	2.1	-2.1	2.1	2.0
Time in closed arm before self-admin	6.0	7.7	7.9	2.8	-2.8	2.8	2.7
Time in closed arm after self-admin	4.8	5.2	5.8	2.4	-2.4	2.4	1.8
Time in open arm before self-admin	4.3	4.7	5.6	-2.1	2.1	-2.1	-2.4
Time in open arm after self-admin	7.6	8.4	8.9	-3.0	3.0	-3.0	-2.6
Bone: periosteal estimation	0.1	0.2	0.3	0.5	-0.5	0.5	0.3
Bone: periosteal perimeter	0.0	0.0	0.1	0.2	-0.2	0.2	0.2
Bone: post-yield work	2.2	3.3	3.4	-1.8	1.8	-1.8	-1.8
Progressive ratio test 1 active lever presses	0.3	0.4	0.5	0.7	-0.7	0.7	0.6
Progressive ratio test 1 breakpoint	0.4	0.5	0.5	0.7	-0.7	0.7	0.7
Progressive ratio test 1 inactive lever presses	1.6	2.3	2.4	-1.5	1.5	-1.5	-1.6
Progressive ratio test 2 active lever presses	0.5	0.6	0.7	0.8	-0.8	0.8	0.4
Progressive ratio test 2 breakpoint	0.4	0.5	0.6	0.8	-0.8	0.8	0.3
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.4
Incentive Sensitization - Responses	0.3	0.4	0.5	0.7	-0.7	0.7	0.2
Incentive Sensitization - Breakpoint	0.3	0.3	0.4	0.7	-0.7	0.7	0.2
Sum of active levers in priming session hrs 5-6	0.5	0.4	0.5	-0.7	0.7	-0.7	-0.4
Progressive ratio	0.7	1.1	1.3	1.1	-1.1	1.1	0.6
Food seeking constrained by brief footshock	0.4	0.5	0.6	-0.8	0.8	-0.8	-0.5
Seeking ratio, punishment vs. effort	1.1	1.6	1.9	-1.4	1.4	-1.4	-0.7
Retroperitoneal fat weight	0.0	0.1	0.3	-0.0	0.0	-0.0	0.5
Reaction time number correct	2.9	5.6	6.1	-2.3	2.3	-2.3	-2.5
Reaction time mean minus median	0.0	0.0	0.0	-0.0	0.0	-0.0	0.1
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.0
Reaction time num false alarms	2.4	3.4	3.8	-1.9	1.9	-1.9	-1.5
Reaction time num false alarms AUC	2.3	3.6	3.9	-2.0	2.0	-2.0	-1.6
Reaction time trials correct on left	2.9	5.6	6.1	-2.3	2.3	-2.3	-2.5
Reaction time trials on left	3.0	5.7	6.2	-2.4	2.4	-2.4	-2.5
Reaction time mean	0.7	1.1	1.3	1.0	-1.0	1.0	1.1
Reaction time mean AUC	0.3	0.5	0.6	0.7	-0.7	0.7	0.8
Median of all reaction times	0.6	0.9	0.9	0.9	-0.9	0.9	0.9
Reaction time omissions	0.5	0.8	1.0	-0.8	0.8	-0.8	-1.0
Reaction time false alarm rate	0.4	0.5	0.6	-0.8	0.8	-0.8	-0.4
Reaction time premature initiation rate	0.2	0.2	0.6	-0.3	0.3	-0.3	-0.8
Reaction time premature initiations	1.5	2.6	3.8	-1.5	1.5	-1.5	-1.9
Std. dev. reaction times	0.3	0.6	0.6	0.8	-0.8	0.8	0.8
Reaction time trials completed	3.0	5.7	6.2	-2.4	2.4	-2.4	-2.5
Reaction time trials AUC	3.1	5.8	6.5	-2.4	2.4	-2.4	-2.5
Run reversals in cocaine runway, females	1.1	1.1	1.2	1.0	-1.0	1.0	1.1
Run reversals in cocaine runway, males	0.0	0.0	0.0	0.1	-0.1	0.1	-0.2
Latency to leave start box in cocaine runway	0.8	0.9	0.9	1.0	-1.0	1.0	0.9
Latency to leave start box in cocaine runway, F	0.8	0.9	1.0	1.0	-1.0	1.0	0.8
Latency to leave start box in cocaine runway, M	0.2	0.1	0.3	0.3	-0.3	0.3	0.6
Std. dev. time between licks in bursts	0.0	0.0	0.0	0.1	-0.1	0.1	-0.2
Total sessions with >9 infusions	0.6	0.8	0.8	0.9	-0.9	0.9	0.8
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.1
Short access day 10 total inactive lever presses	0.1	0.3	0.3	-0.5	0.5	-0.5	-0.4
Short access day 1 total infusions	0.0	0.0	0.0	0.1	-0.1	0.1	-0.0
Short access day 10 total infusions	0.5	0.7	0.9	0.8	-0.8	0.8	0.9
Short access total infusions	0.8	1.0	1.1	1.1	-1.1	1.1	0.9
Short access day 1 locomotion	0.8	0.9	1.0	1.0	-1.0	1.0	0.9
Short access day 10 total locomotion	0.4	0.7	1.4	0.7	-0.7	0.7	1.2
Short access total locomotion	0.4	0.5	0.5	0.7	-0.7	0.7	0.7
One hour access (0.3 mA shock)	0.2	0.2	0.2	-0.5	0.5	-0.5	-0.2
Compulsive drug intake	0.9	1.1	1.2	-1.1	1.1	-1.1	-0.8
One hour access (shock baseline)	0.0	0.0	0.0	0.0	-0.0	0.0	0.2
Social response proportion	0.6	0.7	0.9	1.0	-1.0	1.0	0.0
Social responses	0.4	0.5	0.6	0.8	-0.8	0.8	0.4
Social time	0.3	0.4	0.9	-0.4	0.4	-0.4	-0.9
Soleus weight	1.3	3.7	4.3	-2.1	2.1	-2.1	-1.5
Bone: stiffness	0.6	0.9	1.2	-0.9	0.9	-0.9	-1.1
Tibialis anterior weight	0.7	2.3	2.5	-1.6	1.6	-1.6	-1.2
Time to tail flick, vehicle, before self-admin	1.3	1.4	1.6	-1.3	1.3	-1.3	-0.8
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.0	-0.0	0.0	0.2
Time to tail flick, test, before self-admin	0.4	0.5	0.5	0.7	-0.7	0.7	0.6
Time to tail flick, test, after self-admin	1.3	1.3	1.6	-1.1	1.1	-1.1	-1.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1
Delta time to tail flick, test, before/after SA	2.1	2.1	2.2	-1.4	1.4	-1.4	-1.5
Tibia length	0.1	0.3	0.4	-0.5	0.5	-0.5	-0.6
Ambulatory time before self-admin	0.8	1.2	1.2	1.1	-1.1	1.1	1.0
Ambulatory time after self-admin	0.0	0.0	0.0	0.2	-0.2	0.2	0.2
Bone: tissue strength	0.0	0.0	0.0	-0.1	0.1	-0.1	0.2
Total heroin consumption	3.8	4.5	4.9	-2.2	2.2	-2.2	-1.8
Bone: trabecular number	0.2	0.4	0.4	-0.6	0.6	-0.6	-0.6
Bone: trabecular spacing	0.1	0.1	0.1	0.4	-0.4	0.4	0.3
Bone: trabecular thickness	0.0	0.0	0.0	-0.1	0.1	-0.1	0.0
Bone: trabecular tissue density	0.0	0.1	0.1	0.2	-0.2	0.2	0.3
Water consumed over 24 hours	1.1	1.5	2.0	-1.2	1.2	-1.2	-1.4
Number of responses in last shaping day	0.0	0.0	0.0	0.1	-0.1	0.1	0.1