Hub : Genes

Cisd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Cisd3 0.08 0.06 2.6e-06 0.06 0.05 0.03 0.05 6.6e-06 1.7e-05 7.6e-04 2.3e-05
2 NAcc gene expression Cisd3 0.05 0.03 3.6e-10 0.06 0.07 0.06 0.06 6.6e-10 2.5e-10 4.4e-10 4.3e-10
3 PL gene expression Cisd3 0.04 0.03 1.2e-05 0.04 0.04 0.04 0.04 5.4e-05 2.1e-05 2.8e-05 4.0e-05
4 IC gene expression Cisd3 0.12 0.09 6.7e-05 0.08 0.09 0.08 0.07 2.1e-04 1.1e-04 4.0e-04 4.8e-04
5 Brain mRNA stability Cisd3 0.1 0.08 7.7e-05 0.05 0.04 0.04 0.04 1.9e-05 9.1e-05 5.5e-05 8.1e-05
6 Adipose gene expression Cisd3 0.02 0.02 2.5e-03 0.01 0.02 0.01 0.01 9.2e-03 6.6e-03 1.9e-02 1.9e-02
7 BLA gene expression Cisd3 0.11 0.1 1.4e-03 0.04 0.04 0.02 0.04 3.6e-03 4.2e-03 1.8e-02 5.7e-03
8 IL gene expression Cisd3 0.19 0.14 1.5e-03 0.16 0.02 0.14 0.15 1.0e-04 1.0e-01 2.5e-04 2.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.83.03.41.81.81.71.91.7-1.81.61.6
Area under the delay curve0.91.01.60.91.11.30.71.1-0.71.21.1
BMI with tail1.55.17.8-2.6-2.3-2.8-1.4-2.61.3-2.4-2.0
BMI without tail1.54.65.8-2.4-2.2-2.2-2.1-2.22.1-2.0-2.0
Body weight7.432.434.5-5.9-5.8-5.7-5.8-5.65.7-5.6-5.4
Weight adjusted by age0.10.20.3-0.2-0.4-0.4-0.5-0.30.5-0.4-0.4
Bone surface0.00.00.1-0.1-0.1-0.1-0.0-0.00.0-0.2-0.3
Bone volume0.10.10.20.40.30.20.40.3-0.40.10.1
Breakpoint value in progressive ratio session2.02.43.1-1.6-1.6-1.5-1.8-1.51.8-1.4-1.4
Number of licking bursts0.40.70.91.00.80.80.80.9-0.80.70.9
Context. condit. distance diff. score0.30.40.6-0.6-0.6-0.7-0.5-0.80.5-0.6-0.5
Locomotion velocity, session 11.11.21.6-1.0-1.1-1.2-0.9-1.11.0-1.3-1.2
Locomotion distance, session 14.55.66.9-2.4-2.4-2.2-2.6-2.32.6-2.3-2.1
Locomotion velocity, session 20.91.11.6-0.9-1.0-0.9-1.2-0.91.2-1.1-1.0
Locomotion distance, session 21.42.03.2-1.3-1.4-1.1-1.7-1.31.8-1.3-1.2
Locomotion velocity, session 30.20.20.3-0.5-0.5-0.4-0.6-0.20.6-0.5-0.5
Locomotion distance, session 30.70.81.5-0.7-0.9-0.7-1.2-0.71.2-0.8-0.8
Stereotopy head waving bouts, day 33.84.45.22.12.12.02.32.1-2.32.01.8
Stereotopy head waving duration, day 30.70.91.30.90.90.81.11.0-1.10.90.7
Locomotion velocity, session 70.70.81.1-1.0-0.9-0.8-1.1-0.81.0-0.6-0.7
Locomotion distance, session 70.10.20.6-0.4-0.3-0.1-0.7-0.30.80.0-0.0
Stereotopy head waving bouts, day 71.21.42.01.41.21.11.31.3-1.30.90.6
Stereotopy head waving duration, day 70.30.40.60.80.60.50.70.7-0.70.3-0.0
Locomotion velocity, session 86.37.68.4-2.9-2.8-2.9-2.7-2.82.6-2.7-2.7
Locomotion distance, session 81.92.83.4-1.6-1.7-1.6-1.8-1.61.8-1.6-1.6
Degree of sensitization distance0.10.10.3-0.5-0.4-0.4-0.3-0.50.3-0.2-0.2
Degree of sensitization stereotypy1.71.82.51.61.41.41.41.5-1.41.20.8
Conditioned locomotion0.20.20.50.40.50.50.40.7-0.50.50.5
Cocaine response after cond. corrected2.12.53.21.81.61.51.71.6-1.71.41.4
Cocaine response after cond. not corrected3.03.54.72.21.91.91.92.0-1.81.71.6
Cocaine response before conditioning0.60.71.30.80.91.10.51.1-0.41.00.7
Saline control response0.00.10.10.10.20.3-0.00.40.00.30.3
Bone: connectivity density2.53.94.12.02.02.02.02.0-2.01.91.8
Bone: cortical apparent density4.25.77.32.72.52.62.22.6-2.12.32.0
Bone: cortical area0.20.30.40.60.50.60.40.6-0.40.60.4
Bone: cortical porosity1.11.11.81.01.01.01.10.9-1.11.01.4
Bone: cortical porosity1.11.12.10.91.01.01.00.9-1.11.11.4
Bone: cortical thickness1.22.03.11.81.51.61.21.5-1.11.41.2
Bone: cortical thickness4.35.16.42.42.32.51.82.4-1.82.42.3
Bone: cortical tissue density4.25.77.22.72.52.62.22.6-2.12.31.9
Condit. Reinf. active minus inactive responses0.40.40.60.60.70.70.60.6-0.60.80.6
Condit. Reinf. active-inactive response ratio0.80.91.30.70.90.91.00.8-1.01.10.9
Condit. Reinf. active responses0.60.70.90.90.90.80.90.8-0.90.80.8
Condit. Reinf. inactive responses0.50.60.70.90.80.80.80.6-0.80.60.7
Incentive salience index mean1.21.41.71.21.21.31.21.1-1.21.31.2
Condit. Reinf. lever presses1.11.61.91.21.31.31.21.1-1.21.31.4
Condit. Reinf. active minus inactive responses0.60.81.20.90.80.90.71.0-0.70.91.1
Condit. Reinf. active-inactive response ratio0.30.40.50.70.60.60.70.7-0.70.50.6
Condit. Reinf. active responses1.01.42.01.11.11.21.01.4-1.01.21.4
Condit. Reinf. inactive responses1.82.33.01.41.51.61.31.6-1.31.61.7
Condit. Reinf. lever presses0.00.00.10.10.10.2-0.00.40.00.10.4
Condit. Reinf. lever reinforcers received0.91.32.01.01.11.20.91.3-0.91.11.4
Conditioned reinforcement - actives0.61.11.80.61.01.10.91.0-1.01.31.3
Conditioned reinforcement - inactives0.00.10.2-0.10.20.20.1-0.0-0.10.40.5
Conditioned locomotion1.72.23.41.21.41.41.61.2-1.61.51.8
Patch foraging indifference point 0 sec1.22.22.71.41.51.51.41.6-1.41.41.6
Patch foraging indifference point AUC0.10.10.40.0-0.1-0.2-0.0-0.10.1-0.5-0.7
Delay disc. indifference point, 0s delay1.81.92.51.51.51.61.21.3-1.21.41.5
Delay disc. indifference point, 16s delay0.50.60.80.80.80.90.60.9-0.60.80.6
Delay disc. indifference point, 2s delay2.32.63.41.61.71.91.31.7-1.31.61.8
Delay disc. indifference point, 24s delay0.10.10.30.20.10.1-0.10.40.1-0.1-0.5
Delay disc. indifference point, 4s delay0.40.41.00.80.71.00.20.6-0.10.70.7
Delay disc. indifference point, 8s delay0.60.71.20.60.91.00.70.8-0.71.11.0
Indifference point function ln k0.00.00.10.20.10.20.00.2-0.00.30.3
Indifference point function log k0.00.00.10.20.10.20.00.2-0.00.30.3
Patch foraging total patch changes 0 sec0.71.31.61.11.11.11.11.2-1.11.01.2
Patch foraging total patch changes 12 sec3.95.05.62.32.32.32.32.4-2.22.02.2
Patch foraging total patch changes 18 sec0.20.30.60.60.50.30.80.5-0.70.00.3
Patch foraging total patch changes 24 sec1.01.82.51.61.41.31.51.3-1.51.01.0
Patch foraging total patch changes 6 sec0.81.31.71.31.21.11.31.1-1.20.80.9
Patch foraging time to switch 0 sec0.00.10.20.10.20.20.3-0.1-0.30.30.5
Patch foraging water rate 0 sec0.00.00.10.00.00.00.00.30.0-0.1-0.3
Patch foraging water rate 12 sec0.30.60.9-0.6-0.7-0.6-0.9-0.71.0-0.7-0.7
Patch foraging water rate 18 sec0.40.61.10.80.81.00.40.7-0.41.10.9
Patch foraging water rate 24 sec0.30.40.70.40.60.70.50.8-0.50.60.6
Patch foraging water rate 6 sec0.71.01.31.01.11.11.01.1-1.01.00.8
Seeking ratio, delayed vs. immediate footshock0.20.20.4-0.4-0.4-0.6-0.3-0.60.3-0.5-0.6
Distance traveled before self-admin0.20.20.6-0.6-0.4-0.3-0.5-0.80.5-0.10.1
Distance traveled after self-admin0.81.01.8-1.3-1.0-1.0-1.0-1.10.9-0.8-0.8
Extensor digitorum longus weight8.232.433.9-5.7-5.8-5.8-5.6-5.75.6-5.7-5.6
Bone: elastic displacement0.00.00.10.20.20.10.20.2-0.30.10.3
Bone: elastic work0.00.00.0-0.0-0.00.0-0.10.10.2-0.0-0.0
Bone: endosteal estimation1.73.74.9-2.2-2.0-2.0-1.9-1.91.8-1.8-1.7
Bone: endosteal perimeter1.63.54.9-2.2-1.9-2.1-1.7-1.91.6-1.8-1.6
Epididymis fat weight0.00.20.3-0.6-0.4-0.4-0.4-0.30.4-0.2-0.4
Delta time in closed arm before/after self-admin4.13.84.0-1.9-2.0-2.0-1.9-2.01.9-1.9-1.9
Delta time in open arm before/after self-admin0.00.00.10.10.10.1-0.00.10.00.00.3
Diff in mean of infusions in LGA sessions0.10.10.6-0.8-0.4-0.3-0.4-0.30.3-0.1-0.1
Delay discount exponential model param0.50.61.0-0.7-0.8-1.0-0.4-0.80.4-0.9-0.8
Extinction: sum of active levers before priming0.70.71.4-0.8-0.8-0.6-0.9-0.81.0-0.7-1.2
Active lever presses in extinction session 60.00.00.30.10.10.00.10.1-0.1-0.1-0.5
Bone: final force1.21.92.21.31.41.41.21.5-1.21.51.3
Bone: final moment1.01.61.91.21.31.31.11.3-1.11.41.3
Food consumed during 24 hour testing period0.91.31.6-1.0-1.1-1.1-1.2-0.91.2-1.2-1.3
Glucose0.40.61.01.00.80.90.60.9-0.60.70.5
Heart weight3.14.95.5-2.3-2.2-2.3-2.0-2.31.9-2.3-2.1
Delay discount hyperbolic model param0.50.50.9-0.6-0.8-1.0-0.4-0.80.4-0.9-0.8
Intermittent access intake day 1-15 change0.10.20.4-0.6-0.4-0.5-0.3-0.40.2-0.3-0.4
Intermittent access intake escalation0.10.10.4-0.6-0.4-0.4-0.2-0.40.2-0.2-0.4
Intermittent access intake escalation 20.60.71.3-0.8-0.8-0.9-0.5-0.90.5-0.9-1.1
Intermitt. access day 1 inactive lever presses0.10.50.80.50.70.80.50.5-0.60.90.9
Intermitt. access day 15 inactive lever presses0.40.91.41.11.00.81.20.7-1.20.70.8
Intermitt. access escalation Index0.81.21.6-1.1-1.1-1.2-1.1-0.81.1-1.3-0.8
Intermittent access day 1 total infusions0.00.00.1-0.10.00.1-0.10.10.00.30.1
Intermittent access day 15 total infusions0.10.10.5-0.7-0.4-0.4-0.4-0.30.3-0.1-0.3
Intermittent access terminal intake (last 3 days)0.00.00.1-0.20.10.00.10.1-0.20.2-0.0
Intermittent access total infusions0.10.10.3-0.5-0.3-0.3-0.4-0.20.3-0.0-0.4
Intermittent access day 1 locomotion0.20.20.50.20.40.50.30.3-0.30.70.7
Intermittent access day 15 total locomotion0.40.71.00.70.90.90.90.7-0.91.00.7
Intermittent access total locomotion1.21.41.91.01.21.21.21.0-1.21.41.3
Intermittent access standard deviation0.00.10.20.10.30.20.40.2-0.40.30.1
Left kidney weight1.36.27.6-2.3-2.5-2.3-2.7-2.32.8-2.4-2.6
Right kidney weight0.20.81.1-0.7-0.9-0.8-1.0-0.71.0-1.0-1.0
Cocaine induced anxiety3.44.95.4-2.3-2.2-2.3-2.1-2.32.0-2.2-2.3
Post-drug Anxiety0.90.91.5-1.2-1.0-1.0-0.8-1.00.8-0.9-0.8
Baseline Anxiety3.64.24.62.12.12.12.02.1-2.02.02.1
Tail length2.49.417.7-2.5-2.9-2.2-4.1-2.44.2-2.5-3.1
Length with tail5.523.933.5-4.6-4.8-4.3-5.7-4.35.8-4.5-4.8
Length without tail3.310.711.6-3.1-3.3-3.3-3.3-3.23.4-3.4-3.2
Times rat made contact with spout0.80.91.51.21.01.01.01.1-0.90.70.8
Lifetime Intake0.00.00.2-0.4-0.2-0.1-0.2-0.10.20.0-0.1
Liver weight, left0.20.30.8-0.5-0.5-0.5-0.5-0.50.6-0.5-0.9
Liver weight, right0.20.30.60.70.60.70.30.6-0.30.6-0.0
Locomotor activity0.60.91.31.11.00.91.10.8-1.11.00.7
Locomotor testing distance2.95.26.22.12.32.22.52.0-2.52.42.1
Locomotor testing rearing3.57.07.82.82.72.72.72.6-2.72.72.2
Locomotion in novel chamber2.83.67.52.72.02.11.71.8-1.61.51.5
Locomotion in novel chamber post-restriction0.20.30.70.40.50.30.70.6-0.70.30.8
Fecal boli incidents, locomotor time 10.20.20.5-0.2-0.4-0.6-0.1-0.70.1-0.6-0.6
Change in fecal boli incidents, locomotor task0.40.40.70.60.60.80.40.9-0.40.60.5
Time >=10cm from walls, locomotor time 10.70.81.10.90.90.90.80.8-0.91.00.9
Bouts of movement, locomotor time 10.40.40.7-0.8-0.7-0.6-0.7-0.80.7-0.4-0.2
Total resting periods, locomotor time 10.50.60.9-1.0-0.8-0.7-0.8-0.80.8-0.5-0.3
Rest time, locomotor task time 10.00.10.2-0.1-0.2-0.2-0.2-0.40.1-0.20.4
Distance moved, locomotor task time 10.10.10.40.20.30.40.10.6-0.10.50.1
Vertical activity count, locomotor time 10.00.10.2-0.3-0.2-0.2-0.3-0.20.20.1-0.5
Time >=10cm from walls, locomotor time 21.21.82.31.51.41.51.21.1-1.21.51.3
Bouts of movement, locomotor time 20.10.20.40.30.40.40.4-0.0-0.50.60.5
Total resting periods, locomotor time 20.00.10.2-0.00.10.10.2-0.3-0.20.40.4
Rest time, locomotor task time 20.91.22.0-1.1-1.1-1.1-1.0-1.41.0-1.1-0.7
Distance moved, locomotor task time 20.00.00.10.0-0.10.1-0.30.10.3-0.1-0.3
Vertical activity count, locomotor time 20.10.10.2-0.3-0.2-0.1-0.4-0.20.40.0-0.2
Light reinforcement 11.23.04.01.41.71.61.81.9-1.81.82.0
Light reinforcement 20.50.81.00.70.90.90.81.0-0.80.90.9
Bone: marrow area1.63.54.6-2.2-1.9-2.0-1.8-1.91.8-1.8-1.6
Bone: maximum diameter0.00.00.0-0.00.1-0.00.20.1-0.20.10.1
Bone: maximum force0.00.00.10.10.10.20.10.3-0.10.30.1
Bone: maximum moment0.00.00.0-0.00.00.1-0.10.20.10.20.1
Mean time between licks in bursts0.92.33.1-1.6-1.6-1.6-1.4-1.71.4-1.6-1.3
Mean num. licks in bursts0.00.00.0-0.0-0.00.0-0.1-0.00.10.0-0.1
Cd content in liver1.01.11.7-1.3-1.1-1.1-1.0-1.20.9-0.7-0.8
Co content in liver2.32.62.9-1.7-1.6-1.6-1.6-1.51.6-1.5-1.6
Cu content in liver0.70.91.2-0.9-1.0-1.0-0.9-0.90.9-1.1-0.7
Fe content in liver2.22.73.0-1.6-1.7-1.6-1.7-1.61.7-1.7-1.5
K content in liver0.00.00.10.30.10.10.0-0.00.0-0.10.0
Mg content in liver0.10.10.20.50.20.3-0.00.20.10.00.0
Mn content in liver0.00.00.10.30.20.30.10.1-0.00.10.3
Na content in liver0.20.20.40.50.40.30.60.3-0.70.20.5
Rb content in liver1.41.62.01.31.31.31.31.1-1.31.31.4
Se content in liver3.13.74.32.12.01.92.01.9-2.01.81.8
Sr content in liver1.41.21.7-1.0-1.1-0.9-1.3-1.01.3-1.0-1.1
Zn content in liver1.61.82.21.41.31.41.31.2-1.31.31.5
Bone: minimum diameter0.50.91.1-1.1-1.0-0.9-1.0-0.81.0-0.8-1.0
Time in familiar zone, hab. session 10.50.50.70.60.70.70.80.8-0.80.80.5
Time in novel zone, hab. session 10.80.81.10.90.90.81.00.8-1.00.71.0
Total zone transitions, hab. session 12.73.75.0-1.8-1.9-1.7-2.2-1.92.2-1.8-1.8
Total locomotion distance, hab. session 10.10.10.2-0.3-0.2-0.1-0.4-0.10.5-0.20.0
Locomotion velocity, hab. session 10.71.01.7-1.0-1.0-0.8-1.3-0.91.3-0.9-0.7
Time in familiar zone, hab. session 20.80.81.10.60.80.81.00.9-1.00.91.0
Time in novel zone, hab. session 20.00.00.00.20.10.2-0.10.00.10.10.1
Total zone transitions, hab. session 20.70.91.1-1.0-0.9-0.9-1.1-0.91.1-0.8-0.7
Total locomotion distance, hab. session 20.10.10.3-0.5-0.3-0.3-0.4-0.30.3-0.2-0.1
Locomotion velocity, hab. session 20.30.30.6-0.8-0.6-0.5-0.7-0.50.7-0.5-0.4
Novel to familiar place preference ratio1.71.82.4-1.1-1.3-1.2-1.5-1.21.5-1.4-1.6
Novelty place preference1.01.11.5-0.9-1.0-0.9-1.2-0.81.2-1.1-1.2
Time in novel zone, NPP test0.30.30.5-0.4-0.5-0.4-0.7-0.40.7-0.6-0.7
Total zone transitions, NPP test0.50.71.3-0.8-0.8-0.6-1.1-0.71.1-0.7-0.5
Total locomotion distance, NPP test0.00.00.1-0.0-0.00.1-0.20.10.2-0.10.3
Locomotion velocity, NPP test0.40.50.9-0.7-0.7-0.6-0.9-0.60.9-0.7-0.4
Intraocular pressure1.52.12.8-1.5-1.4-1.3-1.6-1.41.6-1.1-1.7
Delta distance traveled before/after self-admin0.60.60.9-0.9-0.8-0.8-0.7-0.80.6-0.7-0.9
Delta ambulatory time before/after self-admin0.20.20.4-0.7-0.5-0.5-0.4-0.20.4-0.5-0.5
Parametrial fat weight0.41.01.40.71.01.10.81.0-0.91.21.1
Pavlov. Cond. lever latency2.53.13.5-1.8-1.8-1.9-1.7-1.81.7-1.8-1.7
Pavlov. Cond. magazine entry latency9.512.213.13.63.53.53.53.6-3.53.43.3
Pavlov. Cond. change in total contacts8.28.710.33.23.13.12.93.2-2.82.82.4
Pavlov. Cond. index score8.911.212.13.43.43.53.33.5-3.33.33.1
Pavlov. Cond. latency score6.98.79.33.03.03.12.93.1-2.82.92.7
Pavlov. Cond. lever contacts3.23.94.22.02.02.01.92.0-1.92.02.0
Pavlov. Cond. magazine entry number13.717.218.6-4.3-4.2-4.2-4.2-4.34.1-4.1-3.7
Pavlov. Cond. intertrial magazine entries1.61.92.2-1.3-1.4-1.3-1.5-1.51.5-1.4-1.2
Pavlov. Cond. lever-magazine prob. diff.10.412.914.03.73.73.73.53.7-3.53.63.3
Pavlov. Cond. response bias10.412.813.83.63.63.73.63.7-3.53.53.3
Pavlov. Cond. lever latency0.30.40.6-0.6-0.6-0.5-0.6-0.80.6-0.5-0.6
Pavlov. Cond. magazine entry latency0.00.10.2-0.0-0.2-0.1-0.4-0.00.4-0.2-0.1
Pavlov. Cond. change in total contacts0.40.60.80.70.70.70.80.9-0.80.70.9
Pavlov. Cond. index score0.10.20.40.50.40.40.40.7-0.40.30.4
Pavlov. Cond. latency score0.10.10.40.40.30.40.30.6-0.20.20.3
Pavlov. Cond. lever contacts0.50.70.90.80.80.70.81.0-0.80.70.8
Pavlov. Cond. magazine entry number0.20.20.4-0.5-0.4-0.5-0.3-0.60.3-0.4-0.6
Pavlov. Cond. intertrial magazine entries1.52.32.5-1.5-1.5-1.5-1.6-1.51.6-1.5-1.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.30.20.20.20.5-0.20.20.3
Pavlov. Cond. response bias0.81.11.31.11.01.01.11.2-1.00.91.1
Time in closed arm before self-admin1.92.43.51.31.51.41.61.6-1.61.41.9
Time in closed arm after self-admin0.30.30.4-0.6-0.6-0.7-0.5-0.60.5-0.6-0.5
Time in open arm before self-admin2.83.03.8-1.6-1.7-1.8-1.6-1.91.6-1.7-1.8
Time in open arm after self-admin0.40.50.6-0.6-0.7-0.7-0.7-0.80.7-0.7-0.6
Bone: periosteal estimation0.10.30.4-0.7-0.6-0.6-0.5-0.50.5-0.4-0.4
Bone: periosteal perimeter0.61.01.4-1.2-1.0-1.1-0.9-1.00.9-0.9-0.9
Bone: post-yield work0.60.91.2-1.1-1.0-1.0-1.0-1.00.9-0.8-0.7
Progressive ratio test 1 active lever presses0.40.40.80.40.60.80.40.9-0.40.90.7
Progressive ratio test 1 breakpoint0.30.40.80.30.60.80.40.9-0.40.90.7
Progressive ratio test 1 inactive lever presses0.10.10.3-0.10.20.20.10.2-0.10.50.5
Progressive ratio test 2 active lever presses0.40.40.60.70.70.70.60.6-0.60.80.4
Progressive ratio test 2 breakpoint0.40.50.70.80.70.80.60.7-0.60.80.5
Progressive ratio test 2 inactive lever presses0.10.20.5-0.3-0.4-0.4-0.4-0.60.4-0.4-0.7
Incentive Sensitization - Responses0.40.61.01.00.80.80.80.6-0.80.70.5
Incentive Sensitization - Breakpoint0.30.40.90.90.70.70.70.4-0.70.60.3
Sum of active levers in priming session hrs 5-60.10.10.20.30.30.40.10.2-0.10.5-0.3
Progressive ratio0.00.00.1-0.1-0.1-0.1-0.2-0.10.2-0.20.3
Food seeking constrained by brief footshock0.50.61.10.60.70.70.81.1-0.80.70.6
Seeking ratio, punishment vs. effort0.20.30.40.60.50.50.60.6-0.50.6-0.2
Retroperitoneal fat weight0.10.61.20.40.70.80.60.8-0.61.01.1
Reaction time number correct0.51.01.2-1.1-1.1-1.0-1.1-1.01.0-1.0-0.6
Reaction time mean minus median0.00.00.1-0.1-0.2-0.2-0.1-0.10.1-0.30.0
Reaction time mean minus median AUC0.20.60.90.80.70.70.80.8-0.80.60.9
Reaction time num false alarms0.50.81.10.90.90.90.80.8-0.81.00.8
Reaction time num false alarms AUC0.30.50.80.80.70.80.60.6-0.60.90.7
Reaction time trials correct on left0.51.01.2-1.1-1.1-1.0-1.1-1.01.0-1.0-0.6
Reaction time trials on left0.50.91.1-1.0-1.0-1.0-1.0-1.01.0-1.0-0.6
Reaction time mean0.00.10.20.40.20.00.40.0-0.4-0.10.1
Reaction time mean AUC0.00.00.10.30.1-0.10.3-0.1-0.3-0.20.1
Median of all reaction times0.20.30.70.80.50.40.80.3-0.80.20.4
Reaction time omissions0.30.40.70.60.60.70.50.8-0.50.70.7
Reaction time false alarm rate1.11.51.91.31.31.31.21.1-1.21.41.0
Reaction time premature initiation rate0.30.30.80.40.60.70.30.6-0.30.60.9
Reaction time premature initiations0.10.10.3-0.4-0.3-0.2-0.5-0.20.5-0.20.2
Std. dev. reaction times0.00.10.10.30.20.10.20.2-0.2-0.00.3
Reaction time trials completed0.50.91.1-1.0-1.0-1.0-1.0-1.01.0-1.0-0.6
Reaction time trials AUC0.40.80.9-0.9-0.9-0.9-0.9-0.90.9-0.9-0.5
Run reversals in cocaine runway, females1.51.51.9-1.2-1.2-1.1-1.3-1.21.3-0.9-1.4
Run reversals in cocaine runway, males0.40.40.90.70.60.40.90.3-0.90.50.5
Latency to leave start box in cocaine runway2.42.73.6-1.8-1.7-1.9-1.4-1.91.4-1.6-1.3
Latency to leave start box in cocaine runway, F2.73.14.3-1.9-1.9-2.1-1.6-1.91.6-1.9-1.2
Latency to leave start box in cocaine runway, M0.40.30.9-0.4-0.5-0.6-0.4-0.80.4-0.4-0.9
Std. dev. time between licks in bursts0.20.30.5-0.5-0.6-0.7-0.3-0.50.3-0.7-0.6
Total sessions with >9 infusions0.00.00.1-0.20.10.1-0.00.30.00.20.2
Short access day 1 total inactive lever presses0.71.01.60.71.01.20.71.0-0.71.31.2
Short access day 10 total inactive lever presses0.20.51.0-1.0-0.8-0.9-0.5-1.00.4-0.7-0.2
Short access day 1 total infusions0.00.00.00.10.10.20.10.2-0.10.00.1
Short access day 10 total infusions0.10.20.30.40.50.40.50.5-0.50.50.0
Short access total infusions0.00.00.0-0.1-0.1-0.0-0.10.10.1-0.1-0.1
Short access day 1 locomotion0.60.70.80.80.90.80.90.9-0.90.80.9
Short access day 10 total locomotion1.93.63.91.71.91.92.01.9-2.01.91.9
Short access total locomotion0.30.30.60.30.50.50.60.6-0.60.60.8
One hour access (0.3 mA shock)0.00.00.1-0.3-0.10.0-0.10.00.10.20.2
Compulsive drug intake0.10.20.50.20.30.50.00.70.00.40.6
One hour access (shock baseline)0.10.10.3-0.5-0.3-0.4-0.2-0.50.1-0.1-0.4
Social response proportion0.10.10.20.00.00.2-0.3-0.00.30.20.5
Social responses0.10.10.30.20.30.30.20.2-0.20.40.5
Social time0.00.00.0-0.1-0.0-0.10.2-0.1-0.2-0.1-0.1
Soleus weight0.51.41.81.31.21.21.21.2-1.21.11.0
Bone: stiffness0.00.00.10.10.20.20.10.3-0.00.30.3
Tibialis anterior weight1.44.75.2-1.9-2.2-2.1-2.2-2.12.3-2.2-2.2
Time to tail flick, vehicle, before self-admin0.20.20.50.40.50.70.30.7-0.30.60.2
Time to tail flick, vehicle, after self-admin0.10.10.20.40.20.10.40.4-0.40.20.0
Time to tail flick, test, before self-admin0.30.30.5-0.7-0.6-0.7-0.5-0.40.4-0.5-0.7
Time to tail flick, test, after self-admin0.10.10.20.40.30.30.40.5-0.40.4-0.2
Delta time to tail flick, vehicle, before/after SA0.50.50.80.70.60.50.90.6-0.90.50.5
Delta time to tail flick, test, before/after SA1.71.82.41.51.41.51.21.3-1.11.41.2
Tibia length0.72.02.2-1.3-1.4-1.4-1.5-1.21.5-1.5-1.5
Ambulatory time before self-admin0.40.61.6-0.9-0.8-0.8-0.8-1.20.8-0.5-0.4
Ambulatory time after self-admin2.32.73.7-1.9-1.6-1.6-1.6-1.71.6-1.5-1.5
Bone: tissue strength0.40.40.6-0.5-0.6-0.7-0.5-0.50.5-0.8-0.8
Total heroin consumption0.30.40.80.90.70.70.60.5-0.60.60.3
Bone: trabecular number5.18.48.72.93.02.92.92.9-2.92.82.7
Bone: trabecular spacing0.81.11.5-1.2-1.1-1.1-1.0-1.11.0-1.0-0.9
Bone: trabecular thickness0.00.00.00.20.10.10.10.1-0.1-0.1-0.1
Bone: trabecular tissue density0.00.00.0-0.1-0.1-0.1-0.2-0.00.2-0.1-0.2
Water consumed over 24 hours0.00.00.0-0.0-0.1-0.1-0.00.10.0-0.2-0.0
Number of responses in last shaping day0.10.10.4-0.0-0.3-0.4-0.2-0.30.2-0.4-0.7