Hub : Genes

Cimip2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	XM_063288530.1	0.03	0.03	2.0e-03	0.01	0.01	0.02	0.01	2.8e-02	1.1e-02	4.5e-03	4.1e-02
2	Brain	isoform ratio	XM_063288529.1	0.04	0.03	4.3e-03	0.02	0.03	0.01	0.02	2.5e-03	2.2e-03	1.2e-02	4.7e-03
3	Liver	alternative TSS	XM_063288533.1	0.04	0.03	1.6e-03	0.01	0.01	0.02	0.01	8.0e-03	7.6e-03	3.0e-03	2.3e-02
4	PL	gene expression	Cimip2b	0.05	0.05	3.1e-03	0.01	0.02	0.02	0.01	3.8e-02	4.7e-03	2.5e-03	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.0	1.7	2.1	1.3	-1.1	-1.3	1.4
Area under the delay curve	0.6	0.7	1.9	-0.9	0.5	1.4	-0.2
BMI with tail	1.3	4.4	4.7	2.2	-2.1	-2.2	1.9
BMI without tail	1.7	5.2	7.0	2.6	-2.5	-2.6	0.8
Body weight	3.0	12.9	17.4	4.2	-4.2	-4.0	1.1
Weight adjusted by age	0.3	0.5	0.8	0.8	-0.7	-0.9	0.4
Bone surface	0.7	1.4	1.7	1.3	-1.2	-1.2	0.9
Bone volume	0.5	1.0	1.1	1.0	-0.9	-1.0	1.0
Breakpoint value in progressive ratio session	0.5	0.6	2.2	0.2	-0.2	0.1	-1.5
Number of licking bursts	2.5	4.1	6.2	2.3	-2.1	-2.5	0.8
Context. condit. distance diff. score	0.1	0.1	0.2	-0.4	0.5	0.4	-0.0
Locomotion velocity, session 1	1.6	1.8	3.1	1.5	-1.8	-0.8	-1.0
Locomotion distance, session 1	0.6	0.7	1.3	1.0	-1.2	-0.5	-0.5
Locomotion velocity, session 2	1.8	2.1	2.5	1.5	-1.4	-1.3	1.6
Locomotion distance, session 2	2.3	3.3	4.6	2.0	-2.1	-1.9	-0.9
Locomotion velocity, session 3	0.3	0.3	0.5	0.5	-0.7	-0.2	-0.6
Locomotion distance, session 3	2.4	2.6	3.7	1.9	-1.9	-1.5	0.9
Stereotopy head waving bouts, day 3	0.8	1.0	3.7	0.2	-0.3	-0.3	-1.9
Stereotopy head waving duration, day 3	0.6	0.7	2.8	-0.3	0.2	0.0	-1.7
Locomotion velocity, session 7	0.1	0.1	0.2	-0.3	0.3	0.4	0.1
Locomotion distance, session 7	0.2	0.3	0.5	0.7	-0.7	-0.4	0.3
Stereotopy head waving bouts, day 7	1.4	1.5	2.0	1.4	-1.4	-1.4	0.3
Stereotopy head waving duration, day 7	0.7	0.9	1.3	1.0	-1.0	-1.1	-0.5
Locomotion velocity, session 8	0.7	0.9	3.0	0.4	-0.5	-0.3	-1.7
Locomotion distance, session 8	0.5	0.8	1.3	0.8	-0.9	-0.7	-1.1
Degree of sensitization distance	1.2	1.2	1.4	-1.2	1.2	1.1	-1.0
Degree of sensitization stereotypy	1.3	1.4	1.6	1.2	-1.2	-1.2	1.1
Conditioned locomotion	0.1	0.1	0.2	0.0	-0.3	0.4	0.4
Cocaine response after cond. corrected	0.9	1.0	1.5	-0.9	0.8	1.2	-1.1
Cocaine response after cond. not corrected	1.0	1.2	3.4	-0.6	0.5	0.8	-1.9
Cocaine response before conditioning	0.8	1.0	1.7	0.9	-0.9	-1.3	-0.8
Saline control response	1.2	1.6	2.1	1.5	-1.4	-1.3	-0.7
Bone: connectivity density	0.6	1.0	2.8	0.7	-0.6	-0.7	1.7
Bone: cortical apparent density	0.1	0.2	0.3	-0.5	0.6	0.2	0.4
Bone: cortical area	1.4	2.2	3.0	1.5	-1.4	-1.7	1.2
Bone: cortical porosity	0.2	0.2	0.2	-0.5	0.5	0.5	-0.1
Bone: cortical porosity	0.0	0.0	0.0	0.1	-0.1	-0.0	0.2
Bone: cortical thickness	0.4	0.7	2.1	0.4	-0.3	-0.7	1.4
Bone: cortical thickness	0.4	0.4	0.7	-0.8	0.8	0.5	-0.3
Bone: cortical tissue density	0.1	0.2	0.4	-0.5	0.6	0.2	0.3
Condit. Reinf. active minus inactive responses	0.3	0.4	0.5	0.7	-0.6	-0.7	0.2
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.9	-0.9	0.9	0.8	-0.4
Condit. Reinf. active responses	2.1	2.6	3.7	1.8	-1.7	-1.9	0.6
Condit. Reinf. inactive responses	2.5	3.0	4.8	1.9	-1.8	-2.2	0.4
Incentive salience index mean	3.7	4.5	6.1	2.5	-2.4	-2.4	0.8
Condit. Reinf. lever presses	9.2	13.0	17.7	4.2	-4.2	-3.9	1.1
Condit. Reinf. active minus inactive responses	0.5	0.6	1.1	0.7	-0.7	-0.6	1.0
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.7	0.1	0.0	0.0	1.3
Condit. Reinf. active responses	1.6	2.2	2.7	1.6	-1.6	-1.6	1.0
Condit. Reinf. inactive responses	1.7	2.2	3.3	1.6	-1.7	-1.8	0.5
Condit. Reinf. lever presses	1.5	2.0	2.6	1.4	-1.4	-1.6	1.3
Condit. Reinf. lever reinforcers received	1.9	2.6	3.2	1.8	-1.8	-1.7	1.0
Conditioned reinforcement - actives	0.7	1.2	4.7	0.2	-0.1	0.4	2.2
Conditioned reinforcement - inactives	0.2	0.4	0.7	-0.5	0.5	0.8	0.5
Conditioned locomotion	1.0	1.3	4.8	0.2	-0.3	0.6	2.2
Patch foraging indifference point 0 sec	0.5	0.9	1.9	1.0	-1.4	-0.5	0.7
Patch foraging indifference point AUC	7.3	10.5	14.1	3.8	-3.6	-3.3	2.1
Delay disc. indifference point, 0s delay	0.8	0.8	1.5	-0.8	0.7	0.8	-1.2
Delay disc. indifference point, 16s delay	0.8	0.9	2.3	-0.9	0.5	1.5	-0.4
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.2	0.0	0.2	0.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	-0.4	0.3	0.5	-0.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.9	-0.5	0.2	1.0	0.3
Delay disc. indifference point, 8s delay	0.0	0.1	0.1	-0.0	-0.2	0.4	0.3
Indifference point function ln k	2.1	3.7	4.9	-2.2	2.0	1.8	-1.6
Indifference point function log k	2.1	3.7	4.9	-2.2	2.0	1.8	-1.6
Patch foraging total patch changes 0 sec	0.8	1.6	2.8	1.4	-1.7	-0.9	1.0
Patch foraging total patch changes 12 sec	2.5	3.3	4.1	1.8	-1.7	-1.7	2.0
Patch foraging total patch changes 18 sec	0.8	1.2	1.6	1.3	-1.2	-1.1	0.8
Patch foraging total patch changes 24 sec	2.4	4.1	4.6	2.2	-2.1	-1.8	2.0
Patch foraging total patch changes 6 sec	3.0	4.6	6.3	2.4	-2.5	-1.8	1.7
Patch foraging time to switch 0 sec	2.2	4.4	6.0	-2.4	2.4	2.1	-1.1
Patch foraging water rate 0 sec	1.4	3.0	4.0	1.9	-2.0	-1.5	1.5
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.1	-0.3	-0.1	-0.3
Patch foraging water rate 18 sec	0.4	0.6	2.1	0.3	-0.3	-0.3	1.5
Patch foraging water rate 24 sec	0.8	1.1	3.1	-0.5	0.6	0.7	1.8
Patch foraging water rate 6 sec	0.6	0.8	1.3	1.0	-1.0	-1.1	-0.4
Seeking ratio, delayed vs. immediate footshock	2.9	3.6	4.2	1.9	-1.9	-1.8	2.1
Distance traveled before self-admin	3.0	4.0	5.9	2.2	-2.4	-2.3	-0.2
Distance traveled after self-admin	0.4	0.5	0.7	0.7	-0.8	-0.8	0.2
Extensor digitorum longus weight	4.1	16.0	20.8	4.5	-4.6	-4.3	2.2
Bone: elastic displacement	5.3	6.1	8.7	-2.9	3.0	2.7	0.0
Bone: elastic work	3.4	4.4	6.5	-2.4	2.6	2.0	1.1
Bone: endosteal estimation	1.4	3.2	4.6	2.1	-2.0	-2.0	-0.2
Bone: endosteal perimeter	1.3	2.8	4.1	2.0	-2.0	-1.7	0.1
Epididymis fat weight	0.3	0.9	1.3	1.1	-1.0	-1.1	-0.2
Delta time in closed arm before/after self-admin	0.3	0.2	0.7	0.4	-0.2	-0.8	0.4
Delta time in open arm before/after self-admin	0.2	0.2	0.5	-0.4	0.2	0.7	0.2
Diff in mean of infusions in LGA sessions	0.2	0.2	0.4	-0.2	0.6	0.1	-0.6
Delay discount exponential model param	0.6	0.6	1.7	0.8	-0.4	-1.3	0.1
Extinction: sum of active levers before priming	3.2	3.5	5.3	-2.0	1.7	2.3	-1.4
Active lever presses in extinction session 6	0.3	0.3	0.5	-0.4	0.5	0.7	0.7
Bone: final force	1.3	2.1	3.5	1.6	-1.5	-1.9	-0.3
Bone: final moment	1.0	1.6	2.8	1.4	-1.3	-1.7	-0.3
Food consumed during 24 hour testing period	0.7	1.0	1.4	1.1	-1.2	-1.1	-0.4
Glucose	2.4	3.7	4.9	2.2	-2.2	-2.2	0.7
Heart weight	0.5	0.8	1.2	1.0	-1.1	-1.0	-0.3
Delay discount hyperbolic model param	0.4	0.5	1.4	0.6	-0.2	-1.2	0.0
Intermittent access intake day 1-15 change	0.3	0.7	1.1	0.9	-0.7	-1.1	0.5
Intermittent access intake escalation	0.2	0.5	0.8	0.7	-0.5	-0.9	0.5
Intermittent access intake escalation 2	0.7	0.8	1.6	0.7	-0.4	-0.8	1.3
Intermitt. access day 1 inactive lever presses	0.4	1.4	2.0	1.3	-1.4	-1.3	-0.5
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.1	0.3	-0.4	-0.3	-0.3
Intermitt. access escalation Index	1.3	1.9	3.6	0.9	-1.0	-1.4	-1.9
Intermittent access day 1 total infusions	0.8	1.3	2.2	-0.9	0.9	1.5	1.2
Intermittent access day 15 total infusions	0.5	0.8	3.1	0.2	0.0	0.0	1.8
Intermittent access terminal intake (last 3 days)	0.6	0.8	2.8	0.5	-0.1	-0.2	1.7
Intermittent access total infusions	0.9	1.1	4.2	0.4	-0.2	0.1	2.0
Intermittent access day 1 locomotion	1.7	2.1	3.6	-1.0	0.8	1.9	1.8
Intermittent access day 15 total locomotion	0.8	1.4	2.6	-0.8	0.9	1.3	1.6
Intermittent access total locomotion	2.3	2.8	4.3	-1.3	1.3	1.9	2.1
Intermittent access standard deviation	0.2	0.4	0.9	0.5	-0.6	-0.4	1.0
Left kidney weight	0.7	3.1	4.5	2.0	-2.1	-1.7	-0.9
Right kidney weight	0.3	1.4	2.2	1.5	-1.5	-1.0	0.3
Cocaine induced anxiety	0.3	0.4	1.2	-0.5	0.4	0.3	-1.1
Post-drug Anxiety	1.4	1.4	3.0	0.8	-0.9	-1.1	-1.7
Baseline Anxiety	0.4	0.5	0.9	0.8	-0.9	-0.7	-0.2
Tail length	1.6	6.3	8.9	3.0	-2.8	-2.8	0.2
Length with tail	1.6	6.9	10.2	3.2	-3.2	-2.7	0.2
Length without tail	0.1	0.4	0.8	0.7	-0.9	-0.4	0.0
Times rat made contact with spout	0.3	0.3	0.7	0.4	-0.3	-0.5	0.8
Lifetime Intake	0.9	1.0	3.8	0.5	-0.3	0.1	1.9
Liver weight, left	0.2	0.3	1.3	0.1	-0.1	-0.2	-1.1
Liver weight, right	0.8	1.4	2.0	-1.4	1.3	1.4	0.1
Locomotor activity	0.0	0.1	0.3	0.1	-0.1	0.0	-0.5
Locomotor testing distance	0.3	0.5	2.0	-0.1	-0.0	0.2	-1.4
Locomotor testing rearing	0.6	1.3	1.4	1.2	-1.2	-1.2	-1.0
Locomotion in novel chamber	0.8	1.1	1.7	-1.0	0.9	1.3	0.9
Locomotion in novel chamber post-restriction	0.7	1.1	1.7	1.1	-0.6	-1.3	1.2
Fecal boli incidents, locomotor time 1	0.8	1.2	1.8	-1.2	1.1	1.3	0.5
Change in fecal boli incidents, locomotor task	1.0	0.9	1.6	1.2	-1.0	-1.0	-0.2
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.1	0.3	-0.6	-0.5	-1.1
Bouts of movement, locomotor time 1	1.8	2.0	2.6	-1.6	1.5	1.6	-0.8
Total resting periods, locomotor time 1	2.3	2.6	3.4	-1.8	1.8	1.7	-0.7
Rest time, locomotor task time 1	1.6	2.0	3.8	-1.5	2.0	1.3	0.3
Distance moved, locomotor task time 1	1.8	2.6	4.3	1.9	-2.1	-1.7	-0.1
Vertical activity count, locomotor time 1	1.2	2.9	3.5	1.7	-1.9	-1.8	-1.4
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.3	0.5	-0.5	-0.6	-0.3
Bouts of movement, locomotor time 2	0.1	0.2	0.7	0.4	-0.8	-0.1	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.0	-0.4	0.2	0.4
Rest time, locomotor task time 2	0.7	0.8	1.5	-1.0	1.2	0.9	-0.1
Distance moved, locomotor task time 2	0.3	0.3	0.6	0.6	-0.6	-0.8	0.0
Vertical activity count, locomotor time 2	1.1	1.5	2.3	1.2	-1.1	-1.5	-1.0
Light reinforcement 1	1.7	4.3	6.9	1.8	-2.2	-1.5	-2.6
Light reinforcement 2	1.9	2.9	5.0	1.6	-1.6	-1.2	-2.2
Bone: marrow area	1.5	3.2	4.6	2.1	-2.0	-2.1	-0.0
Bone: maximum diameter	1.9	3.5	4.8	2.1	-1.9	-2.2	1.0
Bone: maximum force	2.3	4.1	5.9	2.3	-2.2	-2.4	0.4
Bone: maximum moment	1.8	3.1	4.7	2.0	-1.9	-2.2	0.4
Mean time between licks in bursts	0.5	1.3	4.2	-0.7	0.7	0.3	-2.1
Mean num. licks in bursts	1.4	2.2	3.1	-1.7	1.6	1.8	-0.3
Cd content in liver	1.2	1.3	1.9	1.3	-1.1	-1.4	-0.6
Co content in liver	0.6	0.7	2.5	-0.4	0.3	0.2	-1.6
Cu content in liver	1.9	2.2	2.8	-1.5	1.5	1.2	-1.7
Fe content in liver	0.8	1.0	2.1	-0.7	0.5	1.0	-1.4
K content in liver	0.1	0.1	0.4	-0.2	0.1	0.2	-0.6
Mg content in liver	0.3	0.3	0.5	-0.7	0.7	0.6	-0.0
Mn content in liver	0.7	0.8	1.0	0.9	-0.8	-1.0	0.8
Na content in liver	2.6	2.8	7.2	-1.3	1.3	0.8	-2.7
Rb content in liver	4.2	4.9	6.3	-2.5	2.4	2.4	-1.4
Se content in liver	1.5	1.7	2.6	1.6	-1.4	-1.5	0.3
Sr content in liver	0.6	0.5	0.7	0.8	-0.8	-0.8	-0.2
Zn content in liver	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.2
Bone: minimum diameter	0.1	0.1	0.4	-0.2	0.3	0.2	0.6
Time in familiar zone, hab. session 1	1.6	1.6	2.2	-1.2	1.4	0.9	1.5
Time in novel zone, hab. session 1	1.9	1.9	6.9	-0.5	0.3	0.7	-2.6
Total zone transitions, hab. session 1	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.3
Total locomotion distance, hab. session 1	0.1	0.2	0.4	0.3	-0.2	-0.7	0.3
Locomotion velocity, hab. session 1	0.9	1.3	2.3	1.3	-1.1	-1.5	0.5
Time in familiar zone, hab. session 2	1.1	1.1	1.9	-1.3	1.4	1.0	0.3
Time in novel zone, hab. session 2	0.6	0.6	1.4	-0.6	0.4	0.8	-1.2
Total zone transitions, hab. session 2	0.7	0.9	1.4	1.1	-1.2	-0.9	-0.3
Total locomotion distance, hab. session 2	0.7	0.9	1.3	1.1	-1.0	-1.1	0.2
Locomotion velocity, hab. session 2	0.9	1.2	1.7	1.3	-1.2	-1.3	0.4
Novel to familiar place preference ratio	2.0	2.2	2.8	-1.6	1.3	1.7	-1.3
Novelty place preference	3.0	3.2	4.2	-2.0	1.7	2.0	-1.3
Time in novel zone, NPP test	3.8	4.0	5.1	-2.2	1.9	2.2	-1.6
Total zone transitions, NPP test	0.9	1.3	2.0	1.3	-1.4	-1.1	-0.6
Total locomotion distance, NPP test	2.0	2.7	4.0	2.0	-2.0	-1.7	0.2
Locomotion velocity, NPP test	2.4	3.4	4.9	2.2	-2.2	-1.9	0.7
Intraocular pressure	2.6	3.7	5.0	2.2	-2.2	-2.1	0.9
Delta distance traveled before/after self-admin	0.2	0.2	0.3	-0.5	0.5	0.4	-0.6
Delta ambulatory time before/after self-admin	0.7	0.9	1.3	-1.0	1.1	0.8	-0.8
Parametrial fat weight	0.2	0.4	1.7	-0.1	-0.2	0.1	-1.3
Pavlov. Cond. lever latency	5.8	7.3	10.1	-3.2	3.1	2.9	-1.0
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.8	-0.8	-0.8	0.2
Pavlov. Cond. change in total contacts	2.5	2.6	3.6	1.9	-1.9	-1.7	0.8
Pavlov. Cond. index score	2.6	3.2	4.5	2.1	-2.0	-2.0	0.6
Pavlov. Cond. latency score	2.4	3.0	4.2	2.1	-2.0	-1.9	0.7
Pavlov. Cond. lever contacts	5.4	6.4	8.6	2.9	-2.9	-2.7	1.3
Pavlov. Cond. magazine entry number	0.5	0.6	0.7	-0.9	0.8	0.9	-0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	0.5	-0.5	-0.6	0.1
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.0	4.1	2.0	-1.9	-1.9	0.8
Pavlov. Cond. response bias	3.2	4.0	5.4	2.3	-2.3	-2.2	0.7
Pavlov. Cond. lever latency	1.4	2.0	2.9	-1.5	1.4	1.7	-1.0
Pavlov. Cond. magazine entry latency	0.4	0.5	0.6	-0.7	0.8	0.6	-0.6
Pavlov. Cond. change in total contacts	0.2	0.2	0.6	0.3	-0.2	-0.8	0.4
Pavlov. Cond. index score	0.0	0.0	0.2	0.1	0.0	-0.4	0.1
Pavlov. Cond. latency score	0.1	0.1	0.3	0.1	-0.0	-0.4	0.5
Pavlov. Cond. lever contacts	1.0	1.4	2.2	1.2	-1.2	-1.5	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.3	-0.4	0.1	-0.2
Pavlov. Cond. intertrial magazine entries	0.3	0.5	0.6	0.8	-0.7	-0.7	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.0	0.1	-0.4	0.2
Pavlov. Cond. response bias	0.3	0.4	0.8	0.5	-0.5	-0.9	0.3
Time in closed arm before self-admin	0.9	1.1	2.0	-1.0	0.7	1.4	0.9
Time in closed arm after self-admin	0.3	0.3	0.8	-0.6	0.9	0.2	0.1
Time in open arm before self-admin	1.9	2.1	2.9	1.7	-1.4	-1.7	-0.7
Time in open arm after self-admin	1.0	1.1	1.9	1.2	-1.4	-0.8	0.6
Bone: periosteal estimation	1.5	3.3	4.7	2.1	-1.9	-2.2	0.4
Bone: periosteal perimeter	0.6	1.0	1.5	1.2	-1.2	-1.0	0.1
Bone: post-yield work	2.5	3.6	5.1	2.3	-2.2	-2.1	-0.3
Progressive ratio test 1 active lever presses	0.6	0.7	2.4	-0.1	0.2	0.7	1.6
Progressive ratio test 1 breakpoint	0.6	0.7	2.4	0.0	0.2	0.6	1.5
Progressive ratio test 1 inactive lever presses	0.9	1.2	2.1	1.4	-1.5	-0.9	0.2
Progressive ratio test 2 active lever presses	0.6	0.7	1.8	-0.2	0.4	0.9	1.3
Progressive ratio test 2 breakpoint	0.7	0.8	1.9	-0.2	0.4	1.0	1.4
Progressive ratio test 2 inactive lever presses	0.6	1.0	3.5	0.7	-0.3	-0.2	1.9
Incentive Sensitization - Responses	0.1	0.1	0.3	-0.3	0.3	0.6	-0.0
Incentive Sensitization - Breakpoint	0.1	0.2	0.4	-0.4	0.3	0.6	0.0
Sum of active levers in priming session hrs 5-6	1.9	1.8	2.9	-1.4	1.2	1.7	-1.0
Progressive ratio	0.0	0.1	0.2	-0.0	-0.1	0.4	0.3
Food seeking constrained by brief footshock	6.2	7.6	12.5	3.0	-3.5	-2.7	1.3
Seeking ratio, punishment vs. effort	1.6	2.3	3.5	1.7	-1.7	-1.9	0.4
Retroperitoneal fat weight	0.4	1.8	2.3	-1.5	1.5	1.0	-1.3
Reaction time number correct	0.1	0.2	0.3	0.5	-0.6	-0.2	0.5
Reaction time mean minus median	0.1	0.2	0.3	-0.2	0.3	-0.5	0.5
Reaction time mean minus median AUC	0.2	0.4	0.8	0.5	-0.3	-0.9	0.7
Reaction time num false alarms	0.1	0.1	0.4	-0.0	0.1	0.1	0.7
Reaction time num false alarms AUC	0.3	0.4	0.6	0.6	-0.7	-0.4	0.8
Reaction time trials correct on left	0.1	0.2	0.3	0.5	-0.6	-0.2	0.5
Reaction time trials on left	0.1	0.1	0.2	0.4	-0.5	-0.1	0.5
Reaction time mean	1.4	2.3	3.9	-1.8	2.0	1.2	-0.8
Reaction time mean AUC	1.6	2.6	4.5	-1.9	2.1	1.4	-0.6
Median of all reaction times	2.8	3.9	5.7	-2.3	2.4	1.8	-1.3
Reaction time omissions	1.6	2.3	2.6	-1.6	1.6	1.3	-1.5
Reaction time false alarm rate	0.1	0.1	0.1	-0.2	0.3	0.2	0.3
Reaction time premature initiation rate	2.3	3.2	4.9	-2.2	2.2	1.8	-0.3
Reaction time premature initiations	1.2	2.1	3.2	-1.8	1.7	1.5	0.1
Std. dev. reaction times	0.3	0.5	1.1	-0.9	1.0	0.2	-0.4
Reaction time trials completed	0.1	0.1	0.2	0.4	-0.5	-0.1	0.5
Reaction time trials AUC	0.1	0.1	0.2	0.4	-0.5	-0.1	0.4
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.1	0.2	-0.2	-0.3
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.3	0.3	0.4	0.6
Latency to leave start box in cocaine runway	0.3	0.4	0.5	0.6	-0.7	-0.5	0.7
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.2	0.1	0.5	0.4
Latency to leave start box in cocaine runway, M	1.6	1.5	2.2	1.3	-1.5	-1.4	0.1
Std. dev. time between licks in bursts	0.3	0.4	0.5	-0.7	0.7	0.7	-0.4
Total sessions with >9 infusions	0.4	0.5	1.6	0.4	-0.4	0.4	1.3
Short access day 1 total inactive lever presses	0.6	0.8	1.4	1.1	-1.2	-0.6	0.5
Short access day 10 total inactive lever presses	0.3	0.6	1.2	0.7	-0.8	-1.1	-0.4
Short access day 1 total infusions	0.3	0.4	0.6	0.7	-0.6	0.0	0.8
Short access day 10 total infusions	0.1	0.1	0.3	0.3	-0.3	0.1	0.5
Short access total infusions	0.2	0.3	0.8	0.2	-0.2	0.5	0.9
Short access day 1 locomotion	1.3	1.6	3.9	-1.0	0.8	2.0	0.9
Short access day 10 total locomotion	1.4	2.6	3.9	-1.5	1.3	2.0	1.6
Short access total locomotion	0.6	0.8	1.7	-0.6	0.3	1.3	1.0
One hour access (0.3 mA shock)	1.0	1.1	2.9	1.0	-0.7	-0.5	1.7
Compulsive drug intake	0.1	0.2	0.3	0.3	-0.2	-0.5	0.5
One hour access (shock baseline)	0.5	0.8	2.0	0.8	-0.6	-0.2	1.4
Social response proportion	3.1	3.5	6.3	-1.7	1.9	1.1	-2.5
Social responses	0.7	0.9	1.1	1.0	-0.9	-1.0	-0.8
Social time	1.3	1.8	7.0	-0.1	0.2	-0.2	-2.6
Soleus weight	0.7	2.1	6.3	0.9	-1.1	-0.6	-2.5
Bone: stiffness	3.3	5.4	8.1	2.7	-2.5	-2.8	-0.3
Tibialis anterior weight	7.0	23.8	32.1	5.6	-5.7	-5.5	1.0
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.5	-0.7	0.9	1.1	1.2
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.8	0.1	0.0	-0.2	0.9
Time to tail flick, test, before self-admin	0.3	0.4	0.4	0.6	-0.6	-0.6	0.6
Time to tail flick, test, after self-admin	2.3	2.4	6.2	1.1	-0.9	-1.2	2.5
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.0	0.5	-0.4	-0.9	-1.0
Delta time to tail flick, test, before/after SA	0.5	0.5	1.6	-0.3	0.4	0.3	1.3
Tibia length	0.5	1.4	4.3	0.6	-0.7	-0.5	-2.1
Ambulatory time before self-admin	2.2	3.3	4.7	2.1	-2.2	-2.0	0.3
Ambulatory time after self-admin	0.3	0.4	0.5	0.7	-0.7	-0.6	0.1
Bone: tissue strength	0.5	0.5	1.6	0.2	-0.3	-0.6	-1.3
Total heroin consumption	0.6	0.7	1.1	-0.8	0.5	1.0	-0.8
Bone: trabecular number	0.7	1.2	1.4	1.1	-0.9	-1.2	1.2
Bone: trabecular spacing	0.0	0.0	0.1	-0.2	0.3	0.0	-0.0
Bone: trabecular thickness	0.3	0.3	0.5	-0.5	0.5	0.6	0.7
Bone: trabecular tissue density	2.8	4.1	5.5	2.3	-2.3	-2.4	-0.9
Water consumed over 24 hours	0.6	0.8	1.0	0.8	-0.8	-0.9	1.0
Number of responses in last shaping day	0.5	0.5	1.5	0.3	-0.7	0.1	-1.2