Hub : Genes

Chmp6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye mRNA stability Chmp6 0.5 0.19 4.9e-04 -0.02 0 -0.01 -0.01 7.0e-01 3.3e-01 4.1e-01 5.0e-01
2 Adipose gene expression Chmp6 0.23 0.11 0.0e+00 0.26 0.28 0.27 0.28 2.7e-28 5.6e-31 2.0e-30 6.1e-31
3 Brain mRNA stability Chmp6 0.04 0.03 7.5e-04 0.03 0.02 0.01 0.02 4.4e-04 9.8e-03 1.4e-02 1.0e-02
4 BLA gene expression Chmp6 0.16 0.13 2.7e-04 0.07 0.07 0.06 0.07 1.6e-04 1.8e-04 5.7e-04 9.5e-05
5 pVTA gene expression Chmp6 0.06 0.04 5.2e-04 0.05 0.03 0.03 0.04 1.2e-04 3.8e-03 9.1e-04 2.6e-04
6 NAcc mRNA stability Chmp6 0.02 0.02 9.7e-03 0.01 0.01 0 0.01 5.7e-03 1.8e-02 9.1e-02 1.4e-02
7 PL gene expression Chmp6 0.03 0.02 2.1e-03 0.01 0.01 0 0.01 7.8e-03 3.0e-02 7.5e-02 4.5e-02
8 Liver gene expression Chmp6 0.08 0.05 2.0e-07 0.07 0.06 0.07 0.07 4.1e-08 9.1e-08 6.9e-08 4.4e-08
9 NAcc gene expression Chmp6 0.02 0.01 2.2e-03 0.03 0.01 0.01 0.03 6.0e-05 6.7e-03 6.0e-03 1.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.10.20.60.5-0.20.60.50.3-0.10.70.40.7
Area under the delay curve1.11.22.3-1.51.5-1.40.8-1.1-1.0-0.60.7-0.9
BMI with tail0.62.14.81.6-0.91.50.11.90.42.20.52.1
BMI without tail2.16.311.03.3-2.63.1-0.92.71.03.2-0.82.9
Body weight2.29.516.24.0-3.94.0-2.42.42.52.8-2.32.6
Weight adjusted by age2.33.56.22.5-2.52.5-0.91.21.31.7-1.81.9
Bone surface0.20.41.10.4-0.70.5-1.1-0.50.9-0.3-0.9-0.3
Bone volume0.10.20.50.5-0.60.7-0.5-0.00.40.3-0.30.2
Breakpoint value in progressive ratio session0.40.51.00.6-0.70.70.71.00.80.80.20.7
Number of licking bursts0.10.10.30.5-0.40.5-0.20.30.30.2-0.3-0.0
Context. condit. distance diff. score1.82.14.71.1-0.21.01.41.9-0.92.21.32.0
Locomotion velocity, session 12.93.17.3-2.21.5-2.0-0.5-2.7-0.1-2.2-0.3-2.1
Locomotion distance, session 11.72.24.1-1.62.0-1.81.6-0.5-2.0-0.41.7-0.3
Locomotion velocity, session 23.84.47.6-2.82.4-2.70.7-2.5-0.5-2.50.7-2.3
Locomotion distance, session 20.50.71.7-0.50.9-0.61.30.3-1.10.21.20.5
Locomotion velocity, session 31.41.62.9-1.71.2-1.6-0.1-1.7-0.2-1.50.0-1.5
Locomotion distance, session 32.42.74.5-2.12.1-2.11.4-1.4-1.3-1.21.3-1.4
Stereotopy head waving bouts, day 30.60.61.6-0.90.5-0.9-0.3-0.80.3-1.3-0.2-1.2
Stereotopy head waving duration, day 30.30.30.8-0.70.5-0.80.2-0.40.1-0.90.2-0.8
Locomotion velocity, session 70.50.61.1-0.91.0-0.81.0-0.4-0.7-0.21.0-0.0
Locomotion distance, session 73.14.09.2-1.52.5-1.73.00.3-2.50.32.90.5
Stereotopy head waving bouts, day 70.20.20.40.6-0.60.5-0.40.50.40.5-0.30.1
Stereotopy head waving duration, day 70.40.51.10.8-0.90.6-0.90.31.00.0-0.9-0.1
Locomotion velocity, session 80.81.02.4-0.41.0-0.61.50.7-1.30.61.50.6
Locomotion distance, session 82.73.96.41.00.50.62.52.4-2.02.52.32.5
Degree of sensitization distance1.21.23.01.1-0.40.90.91.7-0.31.40.81.6
Degree of sensitization stereotypy0.40.41.10.9-0.60.70.01.00.21.00.00.5
Conditioned locomotion3.23.76.32.5-1.92.5-0.22.50.22.3-0.22.3
Cocaine response after cond. corrected0.10.10.2-0.50.4-0.40.1-0.1-0.40.00.2-0.1
Cocaine response after cond. not corrected0.40.51.1-1.00.9-1.00.3-0.8-0.5-0.50.3-0.5
Cocaine response before conditioning0.40.50.9-0.90.9-1.00.5-0.9-0.4-0.80.3-0.5
Saline control response1.82.44.62.1-2.02.1-1.21.01.11.4-1.01.4
Bone: connectivity density0.10.10.6-0.00.30.10.80.2-0.10.00.70.2
Bone: cortical apparent density1.92.74.6-2.12.1-2.11.6-1.1-1.4-1.11.5-1.1
Bone: cortical area4.26.511.83.0-3.43.0-3.01.12.51.4-2.81.3
Bone: cortical porosity1.31.43.20.2-1.10.6-1.7-1.01.7-0.8-1.8-0.7
Bone: cortical porosity1.31.43.10.6-1.41.0-1.8-0.51.7-0.3-1.7-0.3
Bone: cortical thickness3.55.811.12.7-3.32.8-3.00.92.60.8-2.90.8
Bone: cortical thickness0.91.11.91.2-1.41.3-1.10.80.60.9-1.00.9
Bone: cortical tissue density2.12.95.0-2.22.2-2.21.6-1.2-1.5-1.21.5-1.2
Condit. Reinf. active minus inactive responses1.82.03.31.8-1.61.8-0.61.60.81.6-0.61.5
Condit. Reinf. active-inactive response ratio1.01.02.11.2-0.91.20.11.40.21.30.01.3
Condit. Reinf. active responses3.03.76.52.5-2.32.5-1.11.81.32.0-1.11.9
Condit. Reinf. inactive responses0.70.81.41.2-1.11.2-0.70.60.80.9-0.70.9
Incentive salience index mean1.41.83.21.8-1.61.7-0.81.31.01.4-0.71.3
Condit. Reinf. lever presses0.10.20.40.5-0.20.30.20.6-0.00.60.20.5
Condit. Reinf. active minus inactive responses0.30.40.90.9-0.80.7-0.40.90.40.6-0.20.5
Condit. Reinf. active-inactive response ratio1.41.63.11.4-1.81.3-1.60.61.60.3-1.50.1
Condit. Reinf. active responses0.40.51.40.40.00.10.81.2-0.60.90.90.9
Condit. Reinf. inactive responses1.31.63.6-0.81.4-0.91.90.5-1.80.61.90.6
Condit. Reinf. lever presses1.31.83.90.80.00.51.52.0-1.01.81.51.7
Condit. Reinf. lever reinforcers received1.01.42.80.50.20.21.41.7-1.11.51.51.5
Conditioned reinforcement - actives0.10.10.70.10.00.00.80.20.10.10.30.1
Conditioned reinforcement - inactives0.71.01.81.1-1.11.3-0.80.61.31.0-0.60.9
Conditioned locomotion0.20.30.90.7-0.60.5-0.10.90.10.60.00.2
Patch foraging indifference point 0 sec0.20.31.20.5-0.30.40.51.1-0.20.60.40.3
Patch foraging indifference point AUC0.10.10.30.20.00.00.20.5-0.50.10.20.5
Delay disc. indifference point, 0s delay0.10.10.50.3-0.30.30.70.20.30.4-0.10.3
Delay disc. indifference point, 16s delay1.51.74.2-1.01.6-0.91.8-0.1-2.00.41.80.3
Delay disc. indifference point, 2s delay0.20.20.6-0.60.5-0.50.3-0.80.4-0.4-0.1-0.3
Delay disc. indifference point, 24s delay3.64.17.2-2.72.3-2.60.3-2.5-0.9-1.90.4-2.6
Delay disc. indifference point, 4s delay0.40.40.8-0.80.6-0.90.8-0.4-0.1-0.70.4-0.7
Delay disc. indifference point, 8s delay0.91.02.4-1.30.9-1.2-0.3-1.60.1-0.9-0.5-1.3
Indifference point function ln k0.51.02.1-1.01.3-1.01.5-0.3-0.9-0.21.3-0.4
Indifference point function log k0.51.02.1-1.01.3-1.01.5-0.3-0.9-0.21.3-0.4
Patch foraging total patch changes 0 sec0.30.62.00.6-0.30.50.81.4-0.41.00.80.6
Patch foraging total patch changes 12 sec0.00.10.20.2-0.30.1-0.00.50.20.0-0.1-0.3
Patch foraging total patch changes 18 sec0.91.43.20.10.60.11.81.5-1.61.01.51.1
Patch foraging total patch changes 24 sec0.81.32.61.5-1.21.3-0.41.6-0.01.3-0.31.3
Patch foraging total patch changes 6 sec0.40.61.20.8-1.10.7-0.90.40.80.1-1.10.0
Patch foraging time to switch 0 sec0.30.71.8-1.10.9-0.80.1-1.3-0.2-0.80.1-0.9
Patch foraging water rate 0 sec1.93.99.02.5-1.92.10.23.00.42.50.22.4
Patch foraging water rate 12 sec0.91.94.51.0-0.10.71.42.1-0.91.81.71.5
Patch foraging water rate 18 sec1.32.05.51.6-0.91.21.02.3-0.21.80.91.5
Patch foraging water rate 24 sec4.56.414.92.4-1.12.21.83.9-1.13.41.73.4
Patch foraging water rate 6 sec0.50.82.10.7-0.20.51.31.4-0.10.91.00.8
Seeking ratio, delayed vs. immediate footshock1.11.32.21.3-1.31.30.20.41.40.9-1.31.5
Distance traveled before self-admin0.81.11.71.2-1.31.2-0.20.91.21.1-0.80.9
Distance traveled after self-admin1.31.63.71.3-0.71.20.71.9-0.11.70.81.7
Extensor digitorum longus weight0.72.64.90.80.30.61.92.1-1.32.21.82.1
Bone: elastic displacement0.80.92.01.2-1.41.3-0.71.00.70.5-0.60.4
Bone: elastic work4.35.611.62.6-3.42.9-2.90.92.60.8-2.60.6
Bone: endosteal estimation0.20.41.00.20.40.00.60.5-0.91.00.70.9
Bone: endosteal perimeter0.71.43.21.1-1.41.2-1.8-0.21.20.4-1.70.2
Epididymis fat weight1.24.07.02.5-1.92.4-0.12.60.42.60.12.5
Delta time in closed arm before/after self-admin0.00.00.10.2-0.10.3-0.10.1-0.1-0.40.0-0.0
Delta time in open arm before/after self-admin0.20.20.50.3-0.10.10.70.5-0.30.70.10.5
Diff in mean of infusions in LGA sessions0.20.20.50.3-0.60.2-0.40.00.70.3-0.60.3
Delay discount exponential model param1.71.93.61.9-1.81.9-0.71.50.91.1-0.71.4
Extinction: sum of active levers before priming0.30.40.7-0.70.7-0.70.6-0.2-0.1-0.40.9-0.6
Active lever presses in extinction session 60.30.30.8-0.60.1-0.5-0.1-0.30.9-0.6-0.3-0.9
Bone: final force4.06.411.13.2-3.33.3-2.31.72.12.1-2.02.1
Bone: final moment4.57.313.13.4-3.63.5-2.51.82.32.1-2.32.1
Food consumed during 24 hour testing period0.60.82.41.0-0.90.9-0.71.50.40.90.20.9
Glucose6.39.917.6-4.12.7-3.8-0.2-4.10.1-4.0-0.2-4.2
Heart weight0.60.92.11.0-1.11.0-1.40.50.70.8-1.00.5
Delay discount hyperbolic model param1.51.73.21.8-1.61.8-0.71.50.81.0-0.61.3
Intermittent access intake day 1-15 change0.10.20.70.2-0.50.5-0.0-0.00.90.2-0.30.2
Intermittent access intake escalation0.10.10.50.2-0.40.5-0.0-0.00.70.2-0.30.2
Intermittent access intake escalation 20.70.83.20.6-1.01.0-0.5-0.11.80.2-0.80.4
Intermitt. access day 1 inactive lever presses0.93.35.92.2-1.72.1-0.92.20.32.4-0.22.4
Intermitt. access day 15 inactive lever presses1.02.03.71.6-1.01.70.71.90.21.90.51.8
Intermitt. access escalation Index0.40.61.11.1-0.80.9-0.30.90.20.9-0.31.0
Intermittent access day 1 total infusions0.00.10.10.3-0.30.30.30.4-0.20.10.00.2
Intermittent access day 15 total infusions0.30.40.80.8-0.80.9-0.00.40.50.6-0.50.6
Intermittent access terminal intake (last 3 days)0.40.61.21.0-1.11.10.00.40.80.6-0.70.6
Intermittent access total infusions0.20.20.40.5-0.50.60.40.40.30.4-0.30.4
Intermittent access day 1 locomotion0.10.10.30.4-0.40.4-0.50.20.20.2-0.10.1
Intermittent access day 15 total locomotion0.30.51.00.8-1.00.8-0.60.60.80.3-0.60.3
Intermittent access total locomotion0.20.20.60.6-0.70.7-0.30.40.20.4-0.30.3
Intermittent access standard deviation0.20.40.9-0.80.3-0.70.1-0.60.9-0.8-0.2-0.9
Left kidney weight0.20.91.90.1-0.70.2-1.4-0.71.2-0.9-1.1-1.1
Right kidney weight0.10.61.20.1-0.60.0-1.1-0.50.9-1.0-1.0-0.9
Cocaine induced anxiety1.72.49.10.9-1.61.0-1.9-0.13.00.2-2.10.2
Post-drug Anxiety0.60.73.1-0.4-0.2-0.3-1.0-0.71.8-0.5-0.8-0.6
Baseline Anxiety2.02.33.4-1.81.8-1.80.9-1.1-1.8-1.31.4-1.3
Tail length2.710.519.74.2-4.44.1-3.22.02.92.0-3.21.9
Length with tail1.98.415.93.0-4.03.1-3.70.53.50.4-3.80.4
Length without tail0.72.24.80.7-1.70.9-2.1-0.52.2-0.9-2.1-1.0
Times rat made contact with spout1.11.33.30.9-1.51.0-1.70.51.8-0.2-1.0-0.2
Lifetime Intake0.00.10.20.2-0.10.30.40.30.20.00.10.2
Liver weight, left0.60.92.1-1.00.5-1.1-0.5-1.5-0.0-1.3-0.5-1.2
Liver weight, right2.44.28.12.7-2.92.7-1.91.21.91.1-2.01.1
Locomotor activity0.40.61.1-1.01.0-1.00.8-0.3-0.6-0.60.8-0.6
Locomotor testing distance0.61.12.3-1.01.3-1.11.50.1-1.5-0.11.4-0.0
Locomotor testing rearing0.51.02.4-0.10.6-0.41.51.4-1.20.61.50.3
Locomotion in novel chamber0.00.10.30.3-0.00.2-0.10.5-0.20.10.20.0
Locomotion in novel chamber post-restriction1.22.03.71.6-1.71.7-1.90.41.70.7-1.40.6
Fecal boli incidents, locomotor time 10.10.20.5-0.50.5-0.40.7-0.1-0.5-0.40.2-0.2
Change in fecal boli incidents, locomotor task2.52.54.7-2.01.5-1.71.0-1.90.3-1.80.5-2.2
Time >=10cm from walls, locomotor time 10.60.61.90.40.10.41.31.0-0.70.51.40.3
Bouts of movement, locomotor time 11.11.22.8-1.61.6-1.70.3-1.0-0.6-1.00.7-0.5
Total resting periods, locomotor time 11.61.73.9-1.91.7-2.00.1-1.3-0.5-1.40.6-0.9
Rest time, locomotor task time 10.60.71.4-1.00.4-0.8-0.8-1.20.4-1.1-0.6-1.0
Distance moved, locomotor task time 10.20.40.91.0-0.70.7-0.00.5-0.30.7-0.30.7
Vertical activity count, locomotor time 10.51.32.41.5-0.91.40.01.5-0.11.50.71.4
Time >=10cm from walls, locomotor time 20.20.30.9-0.1-0.2-0.20.4-0.30.5-1.0-0.2-0.9
Bouts of movement, locomotor time 20.50.82.0-1.31.4-1.20.1-0.8-0.7-0.50.8-0.3
Total resting periods, locomotor time 20.20.41.2-0.91.1-0.80.1-0.4-0.6-0.20.70.1
Rest time, locomotor task time 20.20.30.8-0.40.2-0.5-0.9-0.5-0.1-0.8-0.1-0.6
Distance moved, locomotor task time 20.10.10.30.4-0.40.10.3-0.1-0.10.1-0.60.3
Vertical activity count, locomotor time 20.30.40.70.6-0.20.50.70.8-0.40.80.50.8
Light reinforcement 11.02.56.02.0-1.31.70.22.4-0.42.00.41.9
Light reinforcement 21.52.44.92.2-1.92.1-1.21.41.01.3-0.91.1
Bone: marrow area0.20.51.10.20.40.00.60.5-1.01.00.70.9
Bone: maximum diameter1.52.86.01.7-2.11.7-2.40.12.00.3-2.30.3
Bone: maximum force3.66.411.13.3-3.33.3-2.21.62.02.1-2.02.2
Bone: maximum moment4.07.112.63.4-3.53.5-2.41.72.22.1-2.22.1
Mean time between licks in bursts0.51.22.3-1.41.4-1.50.3-1.0-1.2-0.80.6-0.9
Mean num. licks in bursts0.10.10.50.2-0.50.3-0.70.40.50.1-0.10.2
Cd content in liver1.71.94.3-0.31.1-0.62.11.3-1.71.11.91.3
Co content in liver0.00.00.10.2-0.30.3-0.20.00.30.1-0.20.1
Cu content in liver0.70.92.50.7-1.21.0-1.20.11.6-0.2-1.1-0.1
Fe content in liver0.50.62.0-0.30.7-0.61.00.5-1.40.40.90.6
K content in liver1.41.42.91.7-1.31.4-0.41.50.41.3-0.41.3
Mg content in liver0.90.92.01.0-0.30.80.71.4-0.61.30.71.1
Mn content in liver0.10.10.40.3-0.40.3-0.20.10.6-0.2-0.2-0.4
Na content in liver0.00.10.10.3-0.10.10.20.3-0.10.30.10.3
Rb content in liver1.92.35.71.8-1.11.70.52.40.22.00.51.7
Se content in liver0.50.61.30.7-0.40.70.51.1-0.31.00.51.0
Sr content in liver0.70.61.2-0.70.2-0.7-0.6-1.10.6-0.9-0.5-1.1
Zn content in liver1.11.22.11.4-1.41.3-1.20.71.20.5-1.00.7
Bone: minimum diameter2.64.78.52.6-2.92.6-2.11.42.31.4-2.21.2
Time in familiar zone, hab. session 10.10.10.2-0.40.3-0.30.50.0-0.2-0.00.4-0.3
Time in novel zone, hab. session 10.00.00.10.2-0.10.2-0.10.20.00.1-0.00.3
Total zone transitions, hab. session 10.50.71.7-0.40.9-0.51.10.4-1.30.61.20.4
Total locomotion distance, hab. session 10.91.32.90.7-0.10.51.01.7-1.01.71.01.4
Locomotion velocity, hab. session 10.81.22.80.8-0.20.60.81.6-1.01.70.81.4
Time in familiar zone, hab. session 20.60.61.4-0.40.8-0.51.00.3-1.20.71.00.5
Time in novel zone, hab. session 20.10.10.6-0.20.0-0.1-0.2-0.40.4-0.8-0.2-0.6
Total zone transitions, hab. session 21.21.62.80.10.8-0.11.71.3-1.71.31.71.3
Total locomotion distance, hab. session 21.41.83.71.2-0.30.91.11.9-1.01.91.01.9
Locomotion velocity, hab. session 21.51.94.01.5-0.61.20.82.0-0.72.00.82.0
Novel to familiar place preference ratio1.31.52.91.4-1.61.7-0.41.41.60.8-0.60.5
Novelty place preference1.31.42.71.3-1.61.6-0.51.21.60.6-0.60.4
Time in novel zone, NPP test1.11.12.21.2-1.41.5-0.21.31.40.7-0.40.5
Total zone transitions, NPP test1.21.84.20.01.0-0.31.71.1-2.11.21.71.4
Total locomotion distance, NPP test1.92.64.40.90.20.61.82.1-1.82.11.72.1
Locomotion velocity, NPP test1.52.24.01.0-0.00.71.52.0-1.52.01.32.0
Intraocular pressure0.60.81.90.9-0.51.10.31.2-0.21.40.31.1
Delta distance traveled before/after self-admin0.60.61.9-0.10.6-0.21.10.9-1.00.31.40.6
Delta ambulatory time before/after self-admin0.91.23.0-0.81.3-0.91.50.3-1.5-0.21.7-0.2
Parametrial fat weight0.41.11.91.4-1.11.3-0.81.20.11.1-0.31.0
Pavlov. Cond. lever latency3.34.29.2-0.71.8-0.83.01.5-2.81.62.91.8
Pavlov. Cond. magazine entry latency2.02.66.11.3-2.01.4-2.5-0.02.00.1-2.2-0.3
Pavlov. Cond. change in total contacts0.50.61.70.0-0.60.1-0.9-0.41.3-0.5-0.9-0.9
Pavlov. Cond. index score3.34.18.61.8-2.61.8-2.9-0.12.7-0.1-2.8-0.4
Pavlov. Cond. latency score3.44.39.81.5-2.41.6-3.1-0.62.9-0.6-3.0-0.9
Pavlov. Cond. lever contacts1.82.24.90.8-1.50.8-2.2-0.82.1-0.8-2.1-1.0
Pavlov. Cond. magazine entry number2.33.07.3-1.12.0-1.32.70.4-2.30.32.50.8
Pavlov. Cond. intertrial magazine entries0.70.91.60.7-0.10.71.01.1-0.91.30.81.3
Pavlov. Cond. lever-magazine prob. diff.2.93.67.11.8-2.51.8-2.70.22.50.1-2.5-0.3
Pavlov. Cond. response bias2.32.97.11.0-1.91.1-2.7-0.62.3-0.6-2.5-1.0
Pavlov. Cond. lever latency1.92.65.9-1.60.7-1.2-0.9-2.40.8-2.4-0.9-2.4
Pavlov. Cond. magazine entry latency2.32.76.2-0.91.8-1.22.51.0-2.30.72.40.9
Pavlov. Cond. change in total contacts1.52.34.10.00.9-0.32.01.5-2.01.71.91.8
Pavlov. Cond. index score1.62.23.60.20.7-0.11.91.7-1.71.71.71.8
Pavlov. Cond. latency score1.62.13.40.30.6-0.11.81.8-1.71.71.71.8
Pavlov. Cond. lever contacts1.92.65.91.4-0.51.11.22.3-1.02.31.12.4
Pavlov. Cond. magazine entry number1.92.45.60.6-1.50.9-2.4-1.22.1-1.0-2.2-1.1
Pavlov. Cond. intertrial magazine entries0.91.42.61.6-1.51.6-0.81.10.81.0-0.91.0
Pavlov. Cond. lever-magazine prob. diff.1.62.24.0-0.00.9-0.42.01.6-1.91.61.91.7
Pavlov. Cond. response bias1.52.13.70.50.40.21.81.9-1.41.81.61.9
Time in closed arm before self-admin0.91.12.2-1.20.7-1.2-1.2-1.50.1-1.3-0.3-1.2
Time in closed arm after self-admin2.02.14.5-1.61.0-1.3-1.5-1.90.3-2.1-0.2-1.9
Time in open arm before self-admin0.20.20.50.7-0.60.70.30.40.00.2-0.20.2
Time in open arm after self-admin0.50.52.00.5-0.10.31.40.8-0.61.00.40.7
Bone: periosteal estimation1.22.54.02.0-2.02.0-1.70.91.11.4-1.51.2
Bone: periosteal perimeter3.66.113.92.0-3.02.2-3.7-0.63.0-0.2-3.7-0.3
Bone: post-yield work0.00.00.20.00.2-0.10.20.1-0.40.20.20.3
Progressive ratio test 1 active lever presses0.20.30.60.6-0.40.80.20.7-0.00.60.30.7
Progressive ratio test 1 breakpoint0.20.30.70.6-0.50.80.10.60.00.50.20.7
Progressive ratio test 1 inactive lever presses2.73.96.62.6-2.02.5-0.42.50.12.4-0.22.4
Progressive ratio test 2 active lever presses0.10.10.30.4-0.30.40.30.5-0.40.40.30.4
Progressive ratio test 2 breakpoint0.10.10.30.4-0.30.50.30.5-0.40.40.30.4
Progressive ratio test 2 inactive lever presses0.20.30.60.7-0.80.80.10.50.60.4-0.50.5
Incentive Sensitization - Responses0.10.10.70.3-0.20.3-0.10.1-0.80.20.10.2
Incentive Sensitization - Breakpoint0.10.10.60.2-0.20.3-0.00.1-0.80.20.10.2
Sum of active levers in priming session hrs 5-60.60.51.60.3-0.10.60.50.90.41.30.71.0
Progressive ratio0.50.81.6-1.11.1-1.11.2-0.6-0.3-0.70.7-0.6
Food seeking constrained by brief footshock0.20.30.5-0.60.4-0.60.4-0.40.6-0.70.2-0.4
Seeking ratio, punishment vs. effort0.10.10.30.4-0.20.4-0.30.5-0.20.50.10.6
Retroperitoneal fat weight2.912.522.74.6-3.74.3-0.94.80.94.1-0.44.1
Reaction time number correct2.95.510.01.30.40.92.53.2-2.92.92.62.8
Reaction time mean minus median0.20.61.2-0.60.0-0.4-0.8-1.10.7-1.1-0.8-0.8
Reaction time mean minus median AUC0.20.61.70.1-0.50.1-1.3-0.60.7-0.7-1.3-0.5
Reaction time num false alarms0.20.30.6-0.70.7-0.60.2-0.5-0.80.00.3-0.1
Reaction time num false alarms AUC0.30.50.9-0.91.0-0.80.5-0.6-1.0-0.20.5-0.3
Reaction time trials correct on left2.95.510.01.30.40.92.53.2-2.92.92.62.8
Reaction time trials on left3.05.710.31.30.40.92.53.2-2.92.92.62.8
Reaction time mean0.30.41.20.6-0.40.70.30.8-0.20.70.31.1
Reaction time mean AUC0.40.61.70.7-0.30.80.50.9-0.40.90.41.3
Median of all reaction times0.60.82.30.8-0.30.90.61.2-0.41.10.61.5
Reaction time omissions0.30.51.10.9-0.71.0-0.30.50.20.8-0.50.9
Reaction time false alarm rate1.21.74.6-1.50.7-1.2-0.7-2.10.6-1.5-0.8-1.7
Reaction time premature initiation rate1.11.62.9-1.71.7-1.61.1-0.9-1.3-0.61.3-0.5
Reaction time premature initiations1.73.17.6-0.81.7-1.02.41.1-2.81.02.61.1
Std. dev. reaction times0.10.30.5-0.60.7-0.50.6-0.3-0.6-0.30.50.1
Reaction time trials completed3.05.710.31.30.40.92.53.2-2.92.92.62.8
Reaction time trials AUC3.05.810.81.40.30.92.53.3-2.92.92.62.9
Run reversals in cocaine runway, females1.91.95.2-0.91.5-1.12.30.4-2.10.41.80.4
Run reversals in cocaine runway, males1.31.35.50.8-1.31.1-0.90.12.30.0-1.4-0.1
Latency to leave start box in cocaine runway0.60.61.9-0.70.9-0.70.9-0.3-1.4-0.40.9-0.3
Latency to leave start box in cocaine runway, F0.60.72.5-0.10.6-0.21.30.6-1.60.31.20.5
Latency to leave start box in cocaine runway, M0.40.30.6-0.80.5-0.6-0.1-0.8-0.5-0.70.1-0.7
Std. dev. time between licks in bursts1.62.25.21.2-0.20.90.31.9-1.82.31.02.1
Total sessions with >9 infusions0.20.30.6-0.50.6-0.30.8-0.1-0.4-0.50.8-0.3
Short access day 1 total inactive lever presses0.20.20.40.6-0.50.6-0.60.3-0.40.3-0.40.4
Short access day 10 total inactive lever presses1.33.25.72.4-2.12.2-1.31.90.22.1-1.01.7
Short access day 1 total infusions1.01.32.4-1.41.6-1.31.1-0.6-0.8-1.01.4-0.8
Short access day 10 total infusions0.70.91.51.1-1.21.2-1.00.81.00.6-0.80.7
Short access total infusions0.10.10.5-0.10.20.10.50.5-0.20.00.70.2
Short access day 1 locomotion0.30.40.7-0.80.6-0.70.1-0.80.0-0.70.1-0.8
Short access day 10 total locomotion0.40.81.7-0.5-0.1-0.3-0.9-1.31.1-1.0-0.8-1.1
Short access total locomotion0.40.51.1-0.3-0.1-0.1-0.7-0.91.0-0.8-0.6-0.9
One hour access (0.3 mA shock)0.30.30.80.4-0.10.40.70.8-0.40.50.90.6
Compulsive drug intake0.80.92.41.1-0.61.2-0.21.0-0.51.30.31.6
One hour access (shock baseline)0.00.00.10.1-0.20.1-0.0-0.1-0.0-0.2-0.3-0.3
Social response proportion0.30.31.0-0.20.5-0.21.00.4-0.70.40.9-0.0
Social responses0.10.10.60.10.1-0.00.50.8-0.20.20.4-0.2
Social time0.10.20.5-0.10.3-0.20.70.5-0.40.30.6-0.4
Soleus weight1.13.46.02.3-2.42.2-2.10.71.90.8-2.01.2
Bone: stiffness0.40.71.01.0-0.91.0-0.80.20.60.8-0.81.0
Tibialis anterior weight0.00.00.10.10.20.10.3-0.10.10.30.30.3
Time to tail flick, vehicle, before self-admin0.60.61.2-0.50.3-0.5-1.1-0.80.8-0.8-0.5-1.1
Time to tail flick, vehicle, after self-admin1.01.42.4-1.31.0-1.4-0.7-1.50.3-1.6-0.2-1.5
Time to tail flick, test, before self-admin0.50.51.4-0.80.5-0.6-0.3-1.20.5-0.9-0.2-0.7
Time to tail flick, test, after self-admin1.11.12.5-1.00.5-0.9-0.1-1.11.4-1.6-0.2-1.6
Delta time to tail flick, vehicle, before/after SA0.20.20.50.4-0.20.30.40.7-0.60.50.20.6
Delta time to tail flick, test, before/after SA0.40.41.2-0.70.5-0.70.5-0.40.7-0.90.2-1.1
Tibia length6.618.135.04.8-5.95.3-5.31.24.41.2-4.91.6
Ambulatory time before self-admin1.72.54.02.0-2.01.9-0.61.61.51.8-1.01.5
Ambulatory time after self-admin1.11.33.51.2-0.61.00.81.9-0.01.40.81.3
Bone: tissue strength1.81.83.41.9-1.61.7-0.31.60.71.4-0.31.5
Total heroin consumption0.30.41.90.4-0.50.40.40.51.40.4-0.00.5
Bone: trabecular number0.10.10.5-0.20.0-0.0-0.1-0.70.4-0.4-0.1-0.3
Bone: trabecular spacing2.83.78.31.3-0.00.91.92.9-1.72.61.92.3
Bone: trabecular thickness1.11.42.90.1-0.90.5-1.7-1.31.6-0.9-1.7-1.0
Bone: trabecular tissue density0.40.61.5-1.01.0-1.20.0-0.9-0.6-0.70.1-0.4
Water consumed over 24 hours0.50.71.6-0.3-0.3-0.2-0.8-0.71.3-1.2-0.7-1.2
Number of responses in last shaping day0.20.20.60.4-0.50.4-0.8-0.40.4-0.1-0.6-0.0