Cfhr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	NM_001420253.1	0.03	0.02	1.4e-04	0.02	0.03	0.02	0.02	8.8e-04	6.1e-04	1.1e-03	1.3e-03
2	Liver	alternative TSS	XM_063272621.1	0.09	0.06	1.1e-08	0.06	0.06	0.06	0.06	4.9e-07	5.1e-07	3.1e-07	1.9e-07
3	Liver	isoform ratio	XM_006249951.5	0.16	0.07	0.0e+00	0.18	0.18	0.18	0.18	1.0e-19	4.7e-20	2.4e-19	3.7e-19
4	Liver	gene expression	Cfhr2	0.14	0.08	1.1e-16	0.1	0.11	0.11	0.11	1.7e-11	2.5e-12	6.8e-12	9.0e-12
5	Liver	alternative TSS	NM_001420253.1	0.06	0.06	7.5e-03	0.01	0.01	0.01	0.01	6.7e-03	4.6e-02	2.1e-02	1.9e-02
6	Liver	isoform ratio	XM_039091339.2	0.25	0.12	0.0e+00	0.14	0.17	0.16	0.16	2.0e-15	5.1e-18	2.8e-17	2.2e-17
7	Liver	intron excision ratio	chr13_53817677_53820279	0.2	0.09	2.8e-16	0.16	0.14	0.15	0.16	1.3e-17	5.7e-15	4.0e-16	6.0e-17
8	Liver	intron excision ratio	chr13_53729718_53731509	0.23	0.1	0.0e+00	0.13	0.13	0.12	0.13	6.2e-14	2.7e-14	1.7e-13	2.2e-14
9	Liver	isoform ratio	XM_006249950.5	0.21	0.12	6.1e-14	0.1	0.1	0.09	0.1	5.0e-11	9.7e-11	4.2e-10	7.5e-11
10	Liver	mRNA stability	Cfhr2	0.54	0.16	0.0e+00	0.31	0.35	0.35	0.34	8.8e-35	1.1e-39	6.8e-40	4.1e-39
11	Liver	alternative TSS	XM_063272619.1	0.05	0.04	7.8e-03	0.01	0.01	0	0.01	5.2e-02	3.2e-02	1.2e-01	3.4e-02
12	Liver	isoform ratio	XM_063272622.1	0.47	0.2	0.0e+00	0.16	0.15	0.17	0.15	5.1e-17	3.5e-16	1.5e-18	8.3e-17

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	1.6	2.7	4.3	-1.7	2.0	1.2	-1.9	2.1	-2.0	0.3	-1.7	-1.6	-1.4	-1.8	1.3
Area under the delay curve	0.2	0.2	0.8	0.6	-0.6	-0.6	0.4	-0.0	0.2	0.9	0.2	0.6	0.1	-0.3	-0.3
BMI with tail	1.6	5.6	13.6	-2.1	2.1	1.5	-2.5	3.7	-2.5	-0.4	-2.7	-2.8	-2.0	-2.6	2.0
BMI without tail	1.0	3.2	5.3	-2.2	1.9	1.8	-2.3	2.0	-2.2	-1.1	-1.5	-1.2	-1.8	-1.4	1.4
Body weight	2.8	12.4	28.9	-3.1	3.2	2.2	-3.7	5.4	-3.7	-0.1	-3.9	-4.4	-3.0	-3.8	3.2
Weight adjusted by age	0.3	0.5	1.4	-0.7	0.5	0.7	-0.6	-1.0	-0.7	0.3	-0.3	-0.8	-0.8	0.2	1.2
Bone surface	2.6	4.8	7.9	-2.3	2.8	1.8	-2.6	2.5	-2.5	-0.0	-2.3	-2.3	-1.9	-2.0	1.7
Bone volume	1.6	2.8	5.3	-1.7	2.2	1.2	-1.9	2.3	-1.9	0.1	-1.8	-1.6	-1.3	-1.8	1.2
Breakpoint value in progressive ratio session	0.2	0.2	0.9	0.3	0.0	-0.2	0.4	-0.1	0.5	-0.3	0.8	0.2	1.0	0.3	-0.4
Number of licking bursts	0.3	0.4	1.2	-0.9	1.1	0.9	-0.8	0.3	-0.6	-0.8	-0.1	-0.0	-0.6	0.0	0.4
Context. condit. distance diff. score	3.0	3.7	7.1	1.5	-1.4	-0.9	1.9	-1.9	2.2	-1.0	2.7	2.5	2.2	2.0	-2.0
Locomotion velocity, session 1	0.3	0.3	1.9	-0.5	0.4	0.7	-0.3	0.7	0.1	-1.4	0.3	0.2	0.3	0.3	0.1
Locomotion distance, session 1	0.2	0.3	0.7	-0.8	0.7	0.8	-0.6	0.2	-0.4	-0.7	-0.1	-0.0	-0.3	0.2	0.4
Locomotion velocity, session 2	0.4	0.5	1.1	-0.9	0.7	1.0	-0.8	0.4	-0.6	-1.0	-0.4	-0.6	-0.4	0.2	0.7
Locomotion distance, session 2	0.6	0.9	2.5	-1.4	1.3	1.6	-1.1	-0.4	-0.8	-1.2	-0.2	0.1	-0.6	0.7	0.5
Locomotion velocity, session 3	0.9	1.0	4.2	-0.4	0.6	0.9	0.1	-0.4	0.7	-2.1	1.1	0.9	1.0	1.5	-1.0
Locomotion distance, session 3	1.7	1.9	6.6	-1.4	1.1	2.0	-0.6	-0.8	0.1	-2.6	1.2	1.0	0.5	2.1	-0.8
Stereotopy head waving bouts, day 3	0.2	0.2	0.5	0.5	-0.7	-0.4	0.5	-0.3	0.5	-0.2	0.6	0.0	0.6	0.3	-0.1
Stereotopy head waving duration, day 3	0.6	0.7	2.0	1.3	-1.2	-1.4	1.2	-0.1	1.0	0.5	0.3	0.1	0.9	-0.2	-0.5
Locomotion velocity, session 7	0.4	0.5	1.2	-0.1	0.3	0.3	0.1	0.2	0.5	-1.0	0.8	0.9	1.1	0.6	-1.1
Locomotion distance, session 7	0.7	0.9	2.1	-0.5	0.4	0.9	0.0	-0.6	0.5	-1.4	1.1	1.2	0.9	1.4	-1.0
Stereotopy head waving bouts, day 7	2.2	2.5	4.5	2.1	-1.9	-2.0	2.1	-1.2	1.9	0.6	1.3	1.0	1.8	0.5	-1.4
Stereotopy head waving duration, day 7	1.1	1.4	2.6	1.6	-1.3	-1.6	1.6	-1.1	1.4	0.6	0.8	0.6	1.2	0.4	-1.0
Locomotion velocity, session 8	2.0	2.4	6.3	0.3	-0.1	0.4	0.9	-1.0	1.6	-2.5	2.2	1.8	1.9	2.2	-1.5
Locomotion distance, session 8	2.8	4.1	8.5	0.5	-0.3	0.4	1.2	-2.4	1.9	-2.3	2.9	2.9	2.0	2.9	-1.9
Degree of sensitization distance	0.2	0.2	0.8	0.2	-0.0	-0.5	-0.0	0.7	-0.2	0.8	-0.3	-0.2	-0.1	-0.9	0.3
Degree of sensitization stereotypy	2.3	2.5	4.5	2.1	-2.0	-2.0	2.1	-1.2	1.9	0.7	1.3	1.1	1.7	0.5	-1.5
Conditioned locomotion	1.7	2.0	4.0	-0.3	0.3	-0.3	-0.8	1.5	-1.3	1.9	-1.9	-1.6	-1.6	-2.0	1.6
Cocaine response after cond. corrected	0.1	0.1	0.8	0.3	-0.1	-0.3	0.2	-0.9	0.1	0.4	0.3	0.6	-0.0	0.2	-0.3
Cocaine response after cond. not corrected	0.3	0.3	0.7	-0.5	0.8	0.6	-0.3	-0.7	-0.1	-0.8	0.5	0.8	0.0	0.6	-0.5
Cocaine response before conditioning	1.0	1.2	5.0	-1.3	1.5	1.6	-0.9	0.4	-0.3	-2.2	0.5	0.4	0.2	0.9	-0.2
Saline control response	0.5	0.6	1.5	-1.2	1.0	1.2	-1.0	0.1	-0.9	-0.3	-0.2	-0.5	-0.8	0.2	0.8
Bone: connectivity density	2.5	3.9	6.4	-2.0	2.5	1.4	-2.3	2.5	-2.3	0.3	-2.0	-2.1	-1.5	-2.2	1.4
Bone: cortical apparent density	0.2	0.2	1.3	0.4	-0.5	-0.3	0.4	-1.1	0.3	0.6	0.2	0.0	-0.0	0.4	0.1
Bone: cortical area	1.6	2.4	5.5	-1.5	1.7	1.1	-1.7	2.3	-1.7	-0.1	-1.5	-1.7	-1.3	-1.7	1.3
Bone: cortical porosity	4.3	4.6	12.1	-3.2	2.8	3.5	-2.6	1.2	-1.9	-2.9	-0.3	-1.0	-1.2	0.6	1.4
Bone: cortical porosity	3.3	3.6	10.3	-2.8	2.5	3.2	-2.2	0.7	-1.5	-2.9	0.1	-0.5	-0.7	0.9	0.8
Bone: cortical thickness	0.8	1.3	3.0	-0.9	1.1	0.5	-1.2	1.7	-1.3	0.4	-1.2	-1.3	-1.1	-1.4	1.0
Bone: cortical thickness	0.9	1.1	2.2	-1.3	1.5	1.1	-1.4	0.7	-1.4	-0.0	-0.7	-0.9	-0.9	-0.6	1.0
Bone: cortical tissue density	0.1	0.2	1.3	0.3	-0.4	-0.3	0.3	-1.1	0.2	0.5	0.2	0.0	-0.0	0.5	0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.7	0.7	0.8	-0.5	0.5	-0.2	-0.6	0.3	0.0	0.1	0.3	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	1.2	0.3	-0.4	-0.4	0.1	0.6	-0.0	1.1	-0.3	-0.5	-0.1	-0.6	0.3
Condit. Reinf. active responses	0.7	0.9	3.1	-0.9	0.9	1.2	-0.4	-0.0	0.1	-1.8	1.2	1.0	0.6	1.1	-0.5
Condit. Reinf. inactive responses	1.7	2.0	7.7	-0.7	0.9	1.2	-0.1	-0.5	0.5	-2.8	1.9	2.0	1.2	1.7	-1.3
Incentive salience index mean	0.9	1.1	2.8	-1.5	1.7	1.7	-1.1	0.5	-0.7	-1.5	0.3	-0.2	-0.2	0.5	0.5
Condit. Reinf. lever presses	0.6	0.8	3.1	-1.0	1.3	1.3	-0.6	-0.3	-0.1	-1.8	0.8	0.5	0.3	1.0	-0.2
Condit. Reinf. active minus inactive responses	2.4	3.1	11.6	-2.3	1.8	3.0	-1.5	-0.7	-0.8	-3.4	0.7	0.1	-0.4	2.0	0.4
Condit. Reinf. active-inactive response ratio	1.5	1.8	7.5	-0.6	0.4	1.3	0.1	-1.0	0.7	-2.7	1.3	1.1	1.0	2.1	-1.2
Condit. Reinf. active responses	2.8	3.9	11.3	-2.8	2.3	3.3	-2.1	-0.3	-1.3	-3.4	0.2	-0.5	-1.1	1.6	1.2
Condit. Reinf. inactive responses	3.4	4.4	7.3	-2.7	2.5	2.6	-2.6	1.1	-2.4	-1.1	-1.4	-1.8	-2.4	-0.5	2.5
Condit. Reinf. lever presses	2.3	3.2	8.8	-2.7	2.3	3.0	-2.1	-0.0	-1.6	-2.3	-0.0	-0.6	-1.3	1.0	1.3
Condit. Reinf. lever reinforcers received	2.9	4.0	13.6	-2.7	2.2	3.4	-1.9	-0.7	-1.1	-3.7	0.6	-0.1	-0.8	2.0	0.9
Conditioned reinforcement - actives	0.7	1.2	2.5	-1.5	1.6	1.5	-1.3	1.0	-1.1	-1.4	-0.6	-0.5	-0.8	-0.1	0.5
Conditioned reinforcement - inactives	2.8	4.1	7.5	-2.4	2.5	2.2	-2.5	2.7	-2.3	-0.9	-1.6	-1.6	-1.6	-1.4	1.7
Conditioned locomotion	0.5	0.7	2.4	-1.1	1.2	1.3	-0.9	0.4	-0.6	-1.6	-0.2	0.2	-0.5	0.2	-0.1
Patch foraging indifference point 0 sec	0.1	0.2	1.3	0.3	-0.4	-0.0	0.4	-1.1	0.4	-0.3	0.1	-0.2	0.0	0.7	0.1
Patch foraging indifference point AUC	0.2	0.2	0.7	0.6	-0.8	-0.7	0.4	-0.0	0.3	0.8	0.1	0.3	0.2	-0.4	-0.2
Delay disc. indifference point, 0s delay	1.5	1.6	6.0	1.8	-1.5	-2.1	1.3	-0.4	0.8	2.5	-0.5	0.3	-0.1	-0.9	-0.2
Delay disc. indifference point, 16s delay	0.2	0.2	0.5	0.5	-0.7	-0.4	0.5	-0.2	0.5	0.4	0.6	0.6	0.5	0.1	-0.3
Delay disc. indifference point, 2s delay	0.3	0.4	1.0	0.6	-0.5	-0.8	0.3	1.0	0.1	0.9	-0.4	-0.4	-0.0	-1.0	0.0
Delay disc. indifference point, 24s delay	0.2	0.2	0.7	0.6	-0.7	-0.6	0.5	-0.6	0.3	0.8	0.1	0.5	-0.1	0.0	-0.2
Delay disc. indifference point, 4s delay	0.8	0.8	1.9	0.8	-0.8	-0.6	0.9	-0.7	0.9	0.0	1.1	1.4	1.0	0.6	-1.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.6	-0.3	0.2	0.1	-0.4	0.1	-0.6	0.8	-0.6	-0.0	-0.7	-0.5	0.5
Indifference point function ln k	0.2	0.3	0.9	0.5	-0.0	-0.7	0.2	0.9	-0.0	0.7	-0.6	-0.8	-0.2	-0.9	0.4
Indifference point function log k	0.2	0.3	0.9	0.5	-0.0	-0.7	0.2	0.9	-0.0	0.7	-0.6	-0.8	-0.2	-0.9	0.4
Patch foraging total patch changes 0 sec	0.1	0.2	1.3	0.1	-0.2	0.1	0.3	-1.1	0.4	-0.5	0.2	-0.1	0.1	0.8	0.1
Patch foraging total patch changes 12 sec	0.4	0.5	1.8	-0.3	0.1	0.8	0.0	-1.1	0.3	-1.2	0.9	0.5	0.2	1.3	0.0
Patch foraging total patch changes 18 sec	0.8	1.2	2.9	0.8	-1.0	-0.4	1.1	-1.7	1.3	-0.4	1.2	0.9	1.1	1.4	-0.9
Patch foraging total patch changes 24 sec	0.1	0.2	1.2	0.1	-0.6	0.0	0.1	-1.1	0.0	1.0	0.1	-0.1	-0.1	0.4	0.2
Patch foraging total patch changes 6 sec	0.5	0.8	2.3	1.2	-1.5	-1.2	1.1	-1.1	0.9	0.9	0.1	-0.0	0.4	0.2	-0.3
Patch foraging time to switch 0 sec	0.7	1.4	2.4	0.8	-0.9	-0.5	1.1	-1.5	1.3	-0.8	1.4	1.5	1.2	1.5	-1.4
Patch foraging water rate 0 sec	0.2	0.5	2.0	0.0	-0.1	-0.2	-0.2	0.2	-0.3	0.8	-1.0	-1.4	-0.7	-0.6	1.1
Patch foraging water rate 12 sec	0.1	0.1	0.3	0.3	-0.2	-0.4	0.3	0.2	0.3	0.2	0.3	0.6	0.3	-0.1	-0.5
Patch foraging water rate 18 sec	0.3	0.5	1.1	1.0	-1.1	-1.0	0.9	-0.7	0.7	1.0	0.2	-0.2	0.1	0.1	0.1
Patch foraging water rate 24 sec	0.4	0.6	1.4	-0.7	0.5	0.6	-0.7	-0.1	-0.8	0.6	-0.9	-1.0	-1.2	-0.2	1.2
Patch foraging water rate 6 sec	0.7	1.0	1.9	-1.3	1.4	1.4	-1.2	0.9	-1.0	-0.5	-0.7	-0.7	-1.0	-0.2	1.2
Seeking ratio, delayed vs. immediate footshock	1.6	1.9	4.1	1.7	-1.5	-1.5	1.8	-2.0	1.6	0.8	0.9	0.8	1.0	1.1	-1.2
Distance traveled before self-admin	0.1	0.1	0.3	0.3	-0.2	-0.3	0.3	-0.1	0.3	0.5	0.2	-0.5	0.4	-0.0	0.4
Distance traveled after self-admin	3.6	4.5	8.6	-2.3	2.3	2.0	-2.4	1.3	-2.4	0.4	-2.2	-2.9	-2.1	-1.1	2.4
Extensor digitorum longus weight	1.0	3.8	6.7	-2.6	2.2	2.5	-2.5	2.1	-2.1	-1.7	-1.3	-1.5	-1.5	-0.7	1.8
Bone: elastic displacement	1.0	1.2	2.3	0.4	-0.5	0.0	0.8	-0.8	1.1	-1.3	1.5	1.4	1.2	1.4	-1.3
Bone: elastic work	0.9	1.2	1.9	1.0	-1.1	-0.8	1.2	-1.1	1.2	-0.1	1.2	1.4	1.2	0.9	-1.4
Bone: endosteal estimation	0.1	0.2	0.6	0.6	-0.5	-0.6	0.6	0.3	0.6	-0.2	0.4	0.2	0.8	-0.1	-0.4
Bone: endosteal perimeter	0.6	1.2	5.1	-0.6	0.9	0.2	-0.9	2.3	-1.0	0.3	-1.1	-1.1	-0.4	-1.8	0.5
Epididymis fat weight	1.3	4.4	9.0	-2.1	1.9	1.7	-2.3	3.0	-2.3	-0.6	-2.4	-2.1	-2.1	-2.0	1.7
Delta time in closed arm before/after self-admin	1.3	1.2	2.1	1.3	-1.4	-1.4	1.2	0.8	1.2	-0.2	1.1	0.9	1.5	-0.2	-1.1
Delta time in open arm before/after self-admin	0.2	0.2	0.7	0.3	-0.0	-0.1	0.5	-0.8	0.6	-0.3	0.4	0.3	0.5	0.8	-0.6
Diff in mean of infusions in LGA sessions	0.2	0.2	1.2	-0.2	0.7	0.2	-0.2	1.1	-0.0	-0.6	0.5	-0.3	0.3	-0.3	0.4
Delay discount exponential model param	0.2	0.3	0.6	-0.6	0.7	0.6	-0.5	0.2	-0.4	-0.8	-0.4	-0.7	-0.3	0.1	0.4
Extinction: sum of active levers before priming	0.3	0.4	0.8	0.8	-0.5	-0.6	0.8	-0.9	0.8	0.2	0.3	0.1	0.6	0.5	-0.5
Active lever presses in extinction session 6	0.2	0.2	1.4	0.2	0.1	-0.4	0.1	-0.2	-0.1	1.2	-0.4	-0.8	-0.2	-0.3	0.5
Bone: final force	0.2	0.3	0.4	-0.6	0.5	0.5	-0.6	0.6	-0.5	-0.2	-0.5	-0.7	-0.6	-0.3	0.4
Bone: final moment	0.1	0.2	0.3	-0.5	0.5	0.5	-0.5	0.5	-0.4	-0.5	-0.3	-0.5	-0.3	-0.1	0.2
Food consumed during 24 hour testing period	0.9	1.2	1.9	-1.2	1.3	0.9	-1.3	1.2	-1.4	-0.2	-1.0	-1.1	-1.1	-1.1	1.1
Glucose	0.9	1.4	2.6	-1.6	1.3	1.5	-1.5	-0.2	-1.5	-0.3	-1.4	-0.9	-1.6	0.0	0.9
Heart weight	0.9	1.3	2.5	1.6	-1.4	-1.5	1.5	-0.9	1.3	1.4	0.4	0.2	1.0	0.3	-0.9
Delay discount hyperbolic model param	0.2	0.2	0.7	-0.6	0.6	0.6	-0.4	0.0	-0.2	-0.9	-0.1	-0.5	-0.1	0.3	0.3
Intermittent access intake day 1-15 change	0.4	0.9	2.5	1.0	-1.2	-1.4	0.5	0.5	0.0	1.6	-1.0	-0.1	-0.5	-1.2	-0.4
Intermittent access intake escalation	0.4	0.7	1.9	0.5	-0.7	-0.9	-0.0	0.6	-0.5	1.3	-1.4	-0.3	-1.0	-1.3	-0.0
Intermittent access intake escalation 2	1.5	1.7	6.1	1.5	-1.7	-2.0	0.9	-0.2	0.2	2.5	-1.4	-0.3	-0.8	-1.2	-0.1
Intermitt. access day 1 inactive lever presses	1.5	5.6	9.1	-2.8	2.4	2.4	-3.0	2.3	-3.0	-0.3	-2.1	-2.0	-2.5	-1.8	2.6
Intermitt. access day 15 inactive lever presses	1.0	2.0	3.2	-1.6	1.3	1.3	-1.8	1.6	-1.8	-0.2	-1.3	-1.0	-1.5	-1.4	1.6
Intermitt. access escalation Index	0.1	0.2	0.5	-0.5	0.7	0.4	-0.4	0.6	-0.3	-0.7	0.7	0.2	0.3	-0.2	0.0
Intermittent access day 1 total infusions	1.1	1.8	5.8	-1.8	2.0	2.0	-1.4	1.2	-0.8	-2.4	-0.1	-0.2	-0.2	0.4	0.3
Intermittent access day 15 total infusions	0.4	0.6	1.3	-0.8	0.5	0.7	-0.9	1.1	-0.9	-0.5	-1.0	-0.3	-0.8	-0.7	0.0
Intermittent access terminal intake (last 3 days)	0.2	0.3	1.9	0.1	-0.2	-0.4	-0.1	1.4	-0.2	0.1	-0.7	-0.1	-0.2	-1.0	-0.3
Intermittent access total infusions	1.3	1.5	2.6	-1.6	1.6	1.5	-1.5	1.6	-1.3	-1.3	-1.0	-0.5	-1.0	-0.5	0.5
Intermittent access day 1 locomotion	2.2	2.7	6.3	-2.3	2.5	2.3	-2.0	1.4	-1.6	-2.3	-0.7	-0.7	-1.0	-0.3	0.8
Intermittent access day 15 total locomotion	0.4	0.8	1.2	-1.0	0.9	1.0	-1.1	0.8	-1.1	-0.7	-0.8	-0.5	-1.1	-0.5	0.7
Intermittent access total locomotion	2.5	3.0	6.0	-2.3	2.4	2.2	-2.1	1.4	-1.8	-2.0	-1.3	-0.8	-1.7	-0.5	1.1
Intermittent access standard deviation	0.9	1.9	4.8	-0.8	0.5	0.3	-1.3	2.1	-1.5	0.4	-2.2	-1.1	-1.7	-1.9	0.6
Left kidney weight	0.3	1.6	3.2	-1.0	0.6	0.6	-1.3	1.8	-1.5	1.0	-1.4	-1.4	-1.2	-1.6	1.3
Right kidney weight	0.7	3.2	6.4	-2.1	1.7	1.8	-2.2	2.5	-2.1	-0.6	-1.6	-1.6	-1.4	-1.4	1.5
Cocaine induced anxiety	0.4	0.6	2.5	-0.6	0.7	0.9	-0.2	0.0	0.2	-1.6	0.8	0.8	0.5	0.8	-0.6
Post-drug Anxiety	1.2	1.3	3.7	-0.4	0.5	0.9	0.1	-0.3	0.6	-1.9	1.7	1.6	1.2	1.4	-1.1
Baseline Anxiety	0.4	0.5	0.8	0.9	-0.9	-0.8	0.9	-0.2	0.8	0.3	0.6	0.4	0.8	0.2	-0.6
Tail length	0.6	2.2	4.7	-2.2	1.9	2.1	-2.0	1.1	-1.7	-1.4	-0.6	-0.7	-1.2	-0.3	1.2
Length with tail	0.8	3.5	7.2	-1.8	1.9	1.3	-2.0	2.7	-2.0	-0.0	-1.8	-2.5	-1.6	-1.8	2.0
Length without tail	1.2	4.0	11.6	-0.4	0.7	-0.3	-1.1	3.4	-1.4	1.9	-2.5	-2.9	-1.3	-2.9	1.9
Times rat made contact with spout	0.5	0.5	0.8	0.9	-0.8	-0.9	0.9	-0.7	0.8	0.3	0.5	0.9	0.7	0.2	-0.7
Lifetime Intake	1.0	1.2	2.5	-1.4	1.4	1.4	-1.4	1.6	-1.2	-1.1	-0.8	-0.4	-0.8	-0.5	0.4
Liver weight, left	2.4	4.0	8.7	-2.1	2.0	1.6	-2.3	3.0	-2.2	-0.5	-2.0	-2.2	-1.6	-1.9	1.6
Liver weight, right	3.9	6.9	11.6	-2.7	2.9	2.0	-3.0	3.4	-3.0	-0.2	-2.8	-2.7	-2.3	-2.4	2.5
Locomotor activity	1.2	1.9	4.6	-1.6	2.1	1.5	-1.6	0.5	-1.5	-0.2	-1.1	-1.5	-1.2	-0.4	1.8
Locomotor testing distance	0.7	1.3	2.2	-0.9	1.2	0.6	-1.2	1.3	-1.3	0.6	-1.3	-1.3	-1.1	-1.2	1.5
Locomotor testing rearing	0.5	1.1	1.8	-1.3	1.2	1.3	-1.3	0.2	-1.2	-0.4	-0.9	-0.9	-1.2	-0.1	1.2
Locomotion in novel chamber	0.3	0.3	1.1	-0.4	0.1	0.2	-0.6	1.1	-0.7	0.2	-0.6	-0.2	-0.8	-0.8	0.6
Locomotion in novel chamber post-restriction	0.2	0.4	2.2	-0.0	-0.2	0.3	0.2	-1.5	0.2	-0.0	0.4	-0.1	-0.5	0.9	0.9
Fecal boli incidents, locomotor time 1	0.2	0.3	0.9	-0.1	-0.0	0.3	0.1	-0.9	0.3	-0.5	0.9	0.4	0.5	0.9	-0.2
Change in fecal boli incidents, locomotor task	0.3	0.3	1.7	0.3	-0.0	-0.0	0.4	-1.3	0.4	0.3	-0.0	0.2	-0.3	0.9	0.1
Time >=10cm from walls, locomotor time 1	2.9	3.1	6.2	1.2	-1.3	-0.5	1.7	-2.5	1.9	-0.9	2.0	2.3	1.5	2.2	-2.0
Bouts of movement, locomotor time 1	0.7	0.7	1.3	-1.0	1.1	0.9	-1.0	1.2	-0.9	-0.6	-0.5	-0.7	-0.6	-0.6	0.8
Total resting periods, locomotor time 1	0.2	0.2	0.6	-0.7	0.8	0.7	-0.6	0.4	-0.4	-0.6	-0.1	-0.2	-0.3	-0.0	0.5
Rest time, locomotor task time 1	1.2	1.5	3.9	0.9	-0.8	-0.5	1.2	-1.0	1.4	-0.7	2.0	1.3	1.7	1.3	-1.0
Distance moved, locomotor task time 1	0.5	0.8	1.4	-1.1	1.1	1.0	-1.0	0.3	-0.9	-0.5	-1.0	-0.8	-1.2	-0.1	0.8
Vertical activity count, locomotor time 1	0.7	1.6	3.1	-1.3	1.5	1.0	-1.4	1.1	-1.5	0.1	-1.6	-0.8	-1.8	-1.1	1.1
Time >=10cm from walls, locomotor time 2	0.5	0.7	1.6	0.6	-0.8	-0.3	0.8	-1.2	0.9	-0.3	0.9	1.3	0.6	1.0	-1.0
Bouts of movement, locomotor time 2	1.1	1.7	5.8	-1.5	1.2	1.2	-1.5	2.4	-1.4	-0.8	-0.8	-1.2	-0.6	-1.2	0.7
Total resting periods, locomotor time 2	0.7	1.2	5.1	-1.2	1.1	1.0	-1.2	2.3	-1.0	-0.9	-0.4	-0.9	-0.2	-0.9	0.4
Rest time, locomotor task time 2	1.0	1.3	3.4	0.7	-0.3	-0.3	1.0	-0.7	1.2	-0.6	1.8	1.4	1.8	1.2	-1.3
Distance moved, locomotor task time 2	0.6	0.8	1.7	-0.9	0.7	0.7	-0.9	0.6	-1.0	-0.2	-1.1	-0.8	-1.3	-0.6	1.1
Vertical activity count, locomotor time 2	1.7	2.4	3.9	-1.1	1.0	0.6	-1.5	2.0	-1.7	0.5	-2.0	-1.5	-2.0	-1.9	1.6
Light reinforcement 1	2.1	5.1	8.7	1.4	-1.5	-0.6	2.1	-3.0	2.5	-1.8	2.9	2.8	2.1	2.9	-2.1
Light reinforcement 2	2.1	3.3	5.6	1.5	-1.3	-1.0	1.9	-2.1	2.2	-1.3	1.9	2.4	1.6	2.0	-2.0
Bone: marrow area	0.1	0.3	0.7	0.6	-0.5	-0.6	0.6	0.3	0.7	-0.2	0.5	0.3	0.9	-0.0	-0.5
Bone: maximum diameter	1.3	2.5	7.5	-1.1	1.1	0.6	-1.5	2.7	-1.6	0.3	-1.8	-2.0	-1.1	-2.1	1.3
Bone: maximum force	0.8	1.4	2.3	-1.5	1.5	1.3	-1.5	1.0	-1.4	-0.4	-1.0	-1.2	-1.2	-0.6	1.1
Bone: maximum moment	0.6	1.1	2.0	-1.4	1.4	1.3	-1.3	0.8	-1.1	-0.8	-0.6	-1.0	-0.9	-0.3	0.8
Mean time between licks in bursts	0.2	0.6	2.8	-0.7	1.3	1.0	-0.4	-0.0	0.0	-1.7	0.3	0.3	0.2	0.8	-0.3
Mean num. licks in bursts	0.5	0.8	1.8	1.2	-1.3	-1.2	1.1	-0.7	1.0	0.8	0.4	0.5	0.9	0.1	-0.7
Cd content in liver	1.1	1.3	3.4	1.7	-1.5	-1.8	1.4	-0.0	1.0	1.5	0.1	-0.0	0.9	-0.6	-0.5
Co content in liver	2.6	3.0	5.8	2.4	-2.4	-2.2	2.4	-0.9	2.3	0.1	1.2	0.5	2.0	0.7	-1.4
Cu content in liver	3.2	3.8	8.3	2.7	-2.9	-2.9	2.3	-1.0	1.8	1.9	1.3	1.4	1.6	-0.3	-1.5
Fe content in liver	0.5	0.6	1.1	1.0	-0.8	-1.0	0.9	-0.8	0.7	0.7	0.7	1.1	0.6	0.2	-0.8
K content in liver	0.4	0.4	1.4	0.4	-0.6	-0.7	0.0	0.9	-0.3	0.8	-0.6	-0.5	-0.3	-1.2	0.2
Mg content in liver	0.6	0.6	1.6	-0.2	0.0	-0.2	-0.5	1.0	-0.8	0.7	-0.8	-0.9	-0.7	-1.3	0.7
Mn content in liver	0.2	0.2	1.0	0.5	-0.7	-0.7	0.3	0.1	0.0	1.0	-0.2	-0.3	0.1	-0.7	-0.0
Na content in liver	0.2	0.2	0.9	0.6	-0.9	-0.6	0.5	-0.5	0.3	0.6	-0.1	0.1	-0.1	-0.1	-0.2
Rb content in liver	0.9	1.0	3.3	0.7	-1.0	-1.2	0.2	1.6	-0.2	1.6	-0.6	-0.4	-0.1	-1.8	0.1
Se content in liver	0.8	0.9	2.3	1.1	-1.4	-1.5	0.7	0.7	0.3	1.5	-0.3	0.0	0.3	-1.3	-0.4
Sr content in liver	0.9	0.8	1.8	1.2	-1.3	-1.3	0.8	-0.3	0.5	1.2	-0.9	-0.9	-0.5	-0.6	0.3
Zn content in liver	0.7	0.8	2.3	1.0	-1.1	-1.3	0.6	0.8	0.2	1.5	-0.1	-0.2	0.2	-1.3	0.2
Bone: minimum diameter	0.1	0.2	0.7	-0.3	0.2	0.1	-0.4	0.8	-0.5	0.4	-0.2	-0.5	-0.3	-0.8	0.5
Time in familiar zone, hab. session 1	0.7	0.7	1.5	0.1	0.2	0.3	0.4	0.0	0.8	-1.2	1.1	0.9	1.2	1.0	-1.1
Time in novel zone, hab. session 1	0.1	0.1	0.6	0.2	-0.3	-0.4	0.0	-0.6	-0.2	0.7	-0.3	-0.2	-0.5	-0.3	0.4
Total zone transitions, hab. session 1	0.5	0.7	2.2	-0.9	1.1	1.3	-0.5	-0.4	-0.1	-1.5	0.4	0.7	-0.0	1.1	-0.1
Total locomotion distance, hab. session 1	0.4	0.5	1.4	-1.0	1.1	1.2	-0.8	-0.1	-0.5	-1.1	-0.3	-0.2	-0.4	0.5	0.3
Locomotion velocity, hab. session 1	0.6	0.9	2.3	-1.4	1.4	1.5	-1.1	0.0	-0.7	-1.4	-0.5	-0.3	-0.6	0.5	0.4
Time in familiar zone, hab. session 2	0.9	1.0	1.8	-1.2	1.3	1.2	-1.2	0.3	-1.2	-0.3	-0.9	-0.6	-1.3	-0.2	1.0
Time in novel zone, hab. session 2	1.6	1.6	4.1	1.8	-1.7	-2.0	1.5	0.2	1.3	1.1	0.6	0.5	1.4	-0.6	-1.0
Total zone transitions, hab. session 2	1.1	1.4	4.0	-1.1	1.1	1.7	-0.5	-1.6	0.0	-2.0	0.9	0.9	-0.0	2.0	-0.1
Total locomotion distance, hab. session 2	1.2	1.5	4.5	-1.4	1.4	1.9	-0.8	-1.3	-0.2	-2.1	0.6	0.5	-0.2	1.9	-0.0
Locomotion velocity, hab. session 2	1.4	1.9	5.6	-1.6	1.5	2.2	-0.9	-1.3	-0.3	-2.4	0.5	0.4	-0.2	2.0	0.1
Novel to familiar place preference ratio	2.5	2.7	5.1	1.4	-1.5	-0.9	1.7	-1.7	1.9	-0.8	2.3	1.7	2.1	1.7	-1.6
Novelty place preference	2.7	2.9	5.6	1.4	-1.5	-0.9	1.8	-1.6	2.0	-0.9	2.4	1.7	2.2	1.7	-1.7
Time in novel zone, NPP test	3.1	3.3	5.6	1.7	-1.8	-1.3	2.0	-1.5	2.2	-0.5	2.4	1.8	2.4	1.6	-1.9
Total zone transitions, NPP test	0.8	1.2	3.3	-1.1	1.2	1.6	-0.6	-1.2	-0.1	-1.8	0.8	0.8	0.1	1.7	-0.1
Total locomotion distance, NPP test	1.0	1.4	3.7	-1.3	1.3	1.8	-0.8	-1.1	-0.3	-1.9	0.8	0.7	-0.2	1.6	0.2
Locomotion velocity, NPP test	1.2	1.7	4.7	-1.6	1.4	2.1	-1.0	-1.2	-0.4	-2.2	0.7	0.7	-0.4	1.8	0.4
Intraocular pressure	0.1	0.1	0.2	0.4	-0.4	-0.5	0.3	0.1	0.2	-0.0	-0.0	0.3	0.2	-0.3	-0.5
Delta distance traveled before/after self-admin	4.3	4.6	6.9	-2.6	2.5	2.4	-2.6	0.7	-2.6	-0.3	-2.2	-2.4	-2.5	-0.7	2.2
Delta ambulatory time before/after self-admin	3.6	4.4	6.9	-2.6	2.4	2.4	-2.6	0.9	-2.5	-0.4	-2.1	-2.2	-2.4	-0.7	2.1
Parametrial fat weight	2.8	6.5	17.5	-2.4	2.6	1.7	-2.8	4.2	-2.8	-0.6	-2.7	-2.3	-2.3	-2.8	2.0
Pavlov. Cond. lever latency	0.5	0.6	1.6	0.8	-1.0	-1.1	0.5	1.3	0.2	1.0	-0.4	-0.3	0.4	-1.2	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	0.4	-0.5	-0.4	0.2	-0.6	0.1	0.7	-0.2	-0.4	-0.5	-0.1	0.5
Pavlov. Cond. change in total contacts	0.2	0.2	0.7	-0.2	0.4	0.4	0.1	-0.7	0.2	-0.7	0.6	0.6	0.1	0.8	-0.1
Pavlov. Cond. index score	0.2	0.3	1.9	-0.2	0.2	0.4	0.1	-1.4	0.2	-0.5	0.5	0.3	-0.3	0.9	0.1
Pavlov. Cond. latency score	0.3	0.3	1.7	-0.4	0.4	0.6	-0.1	-1.3	-0.0	-0.5	0.4	0.1	-0.4	0.9	0.3
Pavlov. Cond. lever contacts	0.3	0.3	2.1	-0.3	0.5	0.5	-0.1	-1.4	-0.0	-0.4	0.3	0.2	-0.4	0.9	0.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.5	-0.1	0.0	0.0	-0.2	0.7	-0.2	-0.0	-0.2	-0.1	0.2	-0.4	-0.1
Pavlov. Cond. intertrial magazine entries	0.9	1.1	3.9	-0.1	0.7	0.4	0.3	0.5	0.7	-2.0	1.4	1.3	1.5	0.8	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	1.9	-0.2	0.2	0.4	0.1	-1.4	0.2	-0.6	0.5	0.4	-0.2	1.0	0.0
Pavlov. Cond. response bias	0.1	0.2	0.6	-0.4	0.5	0.5	-0.2	-0.8	-0.0	-0.5	0.3	0.1	-0.3	0.6	0.2
Pavlov. Cond. lever latency	1.4	1.8	5.1	1.9	-1.8	-2.3	1.4	0.2	0.9	2.1	-0.3	0.2	0.8	-1.1	-0.9
Pavlov. Cond. magazine entry latency	0.2	0.2	0.5	-0.6	0.3	0.7	-0.4	-0.4	-0.3	-0.5	0.3	-0.0	-0.4	0.5	0.7
Pavlov. Cond. change in total contacts	0.9	1.4	4.9	-1.5	1.2	2.0	-1.0	-0.4	-0.5	-2.2	0.8	0.2	-0.3	1.4	0.5
Pavlov. Cond. index score	0.9	1.2	3.3	-1.6	1.3	1.8	-1.2	-0.2	-0.9	-1.5	0.3	-0.2	-0.7	0.8	1.0
Pavlov. Cond. latency score	0.9	1.2	3.2	-1.5	1.3	1.8	-1.2	-0.3	-0.8	-1.6	0.3	-0.1	-0.7	0.9	0.9
Pavlov. Cond. lever contacts	1.8	2.5	7.0	-2.3	2.1	2.6	-1.8	-0.3	-1.3	-2.2	0.2	-0.4	-1.1	1.2	1.3
Pavlov. Cond. magazine entry number	0.2	0.3	0.7	0.5	-0.2	-0.7	0.2	0.8	0.0	0.7	-0.6	-0.3	0.0	-0.9	-0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.5	1.3	0.8	-0.6	-0.6	0.8	-0.2	0.9	-0.2	0.5	0.6	0.9	0.3	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	2.2	-1.2	1.1	1.5	-0.9	-0.2	-0.6	-1.4	0.4	-0.1	-0.5	0.8	0.8
Pavlov. Cond. response bias	1.1	1.5	4.2	-1.6	1.4	2.1	-1.2	-0.6	-0.8	-1.8	0.6	0.0	-0.7	1.3	0.9
Time in closed arm before self-admin	1.1	1.4	2.3	1.5	-1.4	-1.5	1.4	-1.3	1.2	1.2	0.6	0.7	1.0	0.4	-1.0
Time in closed arm after self-admin	2.8	3.0	6.3	2.4	-2.3	-2.5	2.2	-0.1	1.9	1.4	1.0	1.1	1.8	-0.2	-1.6
Time in open arm before self-admin	2.7	3.0	5.4	-2.3	2.2	2.2	-2.3	1.6	-2.1	-1.1	-1.3	-1.0	-1.6	-0.8	1.4
Time in open arm after self-admin	1.7	1.9	5.3	-2.0	2.0	2.3	-1.6	-0.2	-1.2	-1.6	-0.3	-0.6	-0.9	0.7	0.9
Bone: periosteal estimation	0.3	0.5	2.7	-0.5	0.7	0.2	-0.6	1.6	-0.6	-0.1	-0.5	-0.8	-0.2	-1.1	0.4
Bone: periosteal perimeter	0.8	1.4	4.9	-0.9	1.1	0.4	-1.2	2.2	-1.3	0.3	-1.0	-1.1	-0.6	-1.8	0.6
Bone: post-yield work	0.6	0.8	1.4	-0.8	1.0	0.4	-1.0	0.6	-1.2	0.8	-1.0	-0.8	-1.1	-1.1	1.0
Progressive ratio test 1 active lever presses	4.0	4.9	8.4	-2.9	2.8	2.7	-2.9	2.7	-2.5	-1.6	-1.2	-1.6	-1.6	-1.2	1.8
Progressive ratio test 1 breakpoint	4.1	5.0	8.5	-2.9	2.8	2.7	-2.9	2.8	-2.6	-1.6	-1.3	-1.7	-1.6	-1.3	1.8
Progressive ratio test 1 inactive lever presses	1.8	2.5	4.0	-1.6	1.6	1.2	-1.8	2.0	-1.8	-0.6	-1.6	-1.7	-1.6	-1.6	1.5
Progressive ratio test 2 active lever presses	1.4	1.6	2.8	-1.6	1.5	1.5	-1.6	1.7	-1.5	-0.8	-1.0	-0.8	-1.1	-0.7	0.8
Progressive ratio test 2 breakpoint	1.5	1.7	2.8	-1.6	1.5	1.5	-1.7	1.6	-1.6	-0.8	-1.1	-0.9	-1.2	-0.7	0.9
Progressive ratio test 2 inactive lever presses	1.4	2.2	3.1	-1.6	1.7	1.4	-1.8	1.6	-1.7	-0.3	-1.6	-1.4	-1.7	-1.1	1.6
Incentive Sensitization - Responses	0.1	0.1	0.4	-0.4	0.3	0.4	-0.4	-0.0	-0.4	-0.1	-0.5	-0.2	-0.6	0.2	0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	-0.3	0.2	0.4	-0.3	-0.0	-0.4	-0.1	-0.5	-0.1	-0.6	0.1	0.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	-0.1	0.3	0.0	-0.1	-0.3	-0.2	0.4	-0.0	-0.6	-0.0	0.0	0.3
Progressive ratio	0.9	1.3	3.5	-0.3	-0.1	-0.2	-0.8	0.3	-1.3	1.9	-1.5	-1.5	-1.5	-1.4	1.2
Food seeking constrained by brief footshock	0.9	1.1	2.0	1.2	-1.3	-1.3	1.0	1.4	0.9	0.5	1.1	0.9	1.3	-0.8	-1.0
Seeking ratio, punishment vs. effort	0.9	1.2	3.0	0.3	-0.0	0.0	0.7	0.3	1.1	-1.7	1.7	1.6	1.6	0.9	-1.1
Retroperitoneal fat weight	2.7	11.5	20.7	-3.8	4.0	3.3	-3.9	4.6	-3.6	-1.7	-3.3	-3.2	-3.0	-2.4	2.9
Reaction time number correct	0.1	0.2	1.3	-0.2	0.3	0.3	0.0	-0.5	0.2	-1.1	0.4	0.7	0.0	0.6	-0.1
Reaction time mean minus median	0.4	1.0	2.6	-1.6	1.3	1.6	-1.4	0.3	-1.1	-1.1	-0.4	-0.4	-0.7	0.1	0.6
Reaction time mean minus median AUC	0.4	1.1	2.3	-1.5	1.4	1.4	-1.4	0.5	-1.2	-1.0	-0.7	-0.7	-0.9	-0.3	0.7
Reaction time num false alarms	2.0	2.8	5.8	-1.7	1.1	1.4	-1.8	0.5	-1.9	0.2	-1.8	-2.2	-2.4	-0.7	2.3
Reaction time num false alarms AUC	2.1	3.3	6.0	-2.0	1.4	1.8	-2.1	0.5	-2.2	-0.0	-1.8	-2.4	-2.4	-0.6	2.4
Reaction time trials correct on left	0.1	0.2	1.3	-0.2	0.3	0.3	0.0	-0.5	0.2	-1.1	0.4	0.7	0.0	0.6	-0.1
Reaction time trials on left	0.1	0.2	1.3	-0.3	0.4	0.4	-0.1	-0.5	0.1	-1.1	0.3	0.6	-0.1	0.5	-0.0
Reaction time mean	0.5	0.8	1.7	-0.6	0.3	0.3	-0.9	1.3	-1.0	0.7	-1.2	-1.0	-0.8	-1.3	0.6
Reaction time mean AUC	0.3	0.6	1.5	-0.5	0.3	0.3	-0.7	1.2	-0.8	0.5	-1.0	-0.8	-0.6	-1.1	0.4
Median of all reaction times	0.5	0.7	2.1	-0.2	0.0	-0.1	-0.5	1.5	-0.8	1.0	-1.2	-0.9	-0.6	-1.4	0.4
Reaction time omissions	2.4	3.5	6.5	-2.6	2.5	2.5	-2.5	1.1	-2.2	-1.4	-1.3	-1.2	-1.8	-0.5	1.6
Reaction time false alarm rate	1.7	2.4	5.1	-1.6	1.1	1.4	-1.7	0.6	-1.8	0.4	-1.6	-2.3	-2.0	-0.7	2.0
Reaction time premature initiation rate	0.7	1.0	3.6	-1.3	1.3	1.6	-1.0	0.3	-0.7	-1.9	0.3	0.3	-0.5	0.6	0.2
Reaction time premature initiations	0.6	1.0	4.3	-1.3	1.2	1.5	-0.9	0.1	-0.5	-2.1	0.3	0.4	-0.5	0.6	0.2
Std. dev. reaction times	1.3	2.4	4.2	-2.0	1.8	1.9	-2.1	0.8	-2.0	-0.4	-1.5	-1.3	-1.6	-0.7	1.4
Reaction time trials completed	0.1	0.2	1.3	-0.3	0.4	0.4	-0.1	-0.5	0.1	-1.1	0.3	0.6	-0.1	0.5	-0.0
Reaction time trials AUC	0.1	0.2	1.2	-0.4	0.5	0.5	-0.2	-0.4	-0.1	-1.1	0.2	0.5	-0.2	0.5	0.1
Run reversals in cocaine runway, females	1.3	1.3	3.4	-0.5	0.1	0.2	-0.9	1.2	-1.2	1.2	-1.8	-1.3	-1.4	-1.4	0.8
Run reversals in cocaine runway, males	0.5	0.5	1.7	-1.0	0.7	1.1	-0.8	0.6	-0.5	-1.3	-0.1	0.0	-0.3	0.2	0.0
Latency to leave start box in cocaine runway	0.3	0.3	0.7	0.6	-0.6	-0.4	0.6	-0.8	0.6	-0.1	0.5	0.4	0.5	0.6	-0.8
Latency to leave start box in cocaine runway, F	0.1	0.1	0.8	0.3	-0.3	-0.2	0.3	-0.9	0.2	0.2	-0.4	-0.3	-0.4	0.4	-0.2
Latency to leave start box in cocaine runway, M	0.7	0.6	2.0	0.1	-0.3	0.1	0.4	-0.3	0.6	-0.8	1.4	1.0	1.2	0.8	-0.9
Std. dev. time between licks in bursts	2.5	3.4	5.9	-2.0	2.3	1.7	-2.1	1.1	-2.1	0.1	-1.7	-2.1	-2.1	-1.0	2.4
Total sessions with >9 infusions	0.5	0.6	1.6	-1.1	1.2	1.2	-0.8	0.7	-0.5	-1.3	0.3	0.3	0.1	0.2	0.1
Short access day 1 total inactive lever presses	3.1	4.1	6.3	-2.2	2.1	1.9	-2.5	1.5	-2.5	-0.3	-2.2	-1.9	-2.4	-1.5	2.2
Short access day 10 total inactive lever presses	1.1	2.7	4.5	-2.1	1.9	1.9	-2.0	0.5	-2.0	-0.7	-1.8	-1.4	-2.1	-0.5	1.6
Short access day 1 total infusions	0.7	0.9	2.8	-1.0	0.9	0.7	-1.1	1.7	-1.0	-0.2	-0.8	-0.7	-0.6	-1.0	0.8
Short access day 10 total infusions	0.3	0.4	1.2	-0.7	0.8	0.8	-0.6	0.7	-0.3	-1.1	0.2	0.4	0.2	0.1	-0.2
Short access total infusions	0.4	0.5	1.5	-0.9	0.9	0.9	-0.9	1.2	-0.7	-1.0	-0.3	-0.0	-0.2	-0.3	0.1
Short access day 1 locomotion	0.4	0.5	2.0	-0.7	1.1	0.8	-0.6	0.6	-0.3	-1.4	0.3	-0.1	0.3	0.2	0.4
Short access day 10 total locomotion	0.7	1.2	2.9	-1.5	1.7	1.5	-1.3	-0.1	-1.2	-1.1	-0.9	-0.6	-1.2	0.1	0.7
Short access total locomotion	1.3	1.6	4.1	-1.7	2.0	1.9	-1.4	0.3	-1.0	-2.0	-0.1	-0.1	-0.7	0.5	0.6
One hour access (0.3 mA shock)	0.9	1.1	1.9	-1.4	1.1	1.3	-1.3	0.7	-1.2	-0.7	-1.0	-0.8	-1.1	-0.3	0.8
Compulsive drug intake	0.1	0.1	0.5	0.1	-0.2	-0.3	0.0	-0.1	-0.1	0.7	-0.2	-0.1	-0.2	-0.4	0.2
One hour access (shock baseline)	0.2	0.3	0.8	-0.6	0.6	0.6	-0.6	0.9	-0.6	-0.6	-0.5	-0.3	-0.4	-0.3	0.1
Social response proportion	0.1	0.1	0.4	0.4	-0.1	-0.6	0.2	0.4	0.1	0.4	-0.4	-0.3	0.2	-0.6	-0.4
Social responses	0.2	0.2	0.5	-0.5	0.7	0.4	-0.5	0.7	-0.5	-0.4	-0.4	-0.4	0.0	-0.5	-0.0
Social time	1.1	1.5	4.3	-1.4	1.2	1.2	-1.4	2.1	-1.3	-0.8	-0.7	-1.3	-0.5	-1.0	0.9
Soleus weight	0.4	1.3	2.2	1.2	-1.1	-0.9	1.4	-1.0	1.5	-0.9	1.4	0.7	1.4	0.9	-1.1
Bone: stiffness	2.8	4.6	7.0	-2.2	2.1	1.7	-2.4	1.8	-2.6	0.4	-2.4	-2.6	-2.4	-1.7	2.4
Tibialis anterior weight	0.5	1.7	5.3	-1.8	1.8	2.1	-1.4	0.7	-0.8	-2.3	0.0	-0.4	-0.4	0.7	0.4
Time to tail flick, vehicle, before self-admin	0.7	0.7	3.1	0.6	-0.4	-1.0	0.2	1.8	-0.0	0.8	-0.8	-0.5	0.1	-1.5	-0.2
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.5	1.1	-1.1	-1.2	0.8	0.3	0.6	0.8	0.2	-0.6	0.4	-0.5	0.3
Time to tail flick, test, before self-admin	5.2	5.4	8.3	2.7	-2.5	-2.4	2.8	-1.5	2.8	0.6	2.0	2.9	2.4	1.2	-2.7
Time to tail flick, test, after self-admin	0.3	0.3	1.0	-0.7	0.8	0.9	-0.5	0.2	-0.3	-1.0	0.5	0.2	0.3	0.4	0.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.2	0.7	-1.0	-0.6	0.6	-1.1	0.5	0.7	0.6	-0.2	0.2	0.4	0.3
Delta time to tail flick, test, before/after SA	4.0	4.1	6.3	-2.3	2.0	1.9	-2.5	1.9	-2.5	-0.5	-1.7	-2.5	-1.9	-1.5	2.3
Tibia length	2.0	5.4	8.0	-2.6	2.5	2.1	-2.8	2.8	-2.8	-0.2	-2.2	-2.3	-2.2	-2.0	2.2
Ambulatory time before self-admin	0.2	0.4	0.7	0.8	-0.5	-0.8	0.8	-0.7	0.7	0.6	0.6	-0.2	0.6	0.3	0.2
Ambulatory time after self-admin	2.7	3.2	7.4	-1.9	1.9	1.6	-2.0	1.2	-2.0	0.3	-1.9	-2.7	-1.7	-1.0	2.1
Bone: tissue strength	0.1	0.1	0.3	0.3	-0.2	-0.2	0.3	-0.1	0.4	-0.2	0.3	0.2	0.5	0.2	-0.5
Total heroin consumption	0.1	0.1	0.2	0.3	-0.1	-0.3	0.4	-0.3	0.4	0.4	0.4	0.1	0.5	0.2	-0.3
Bone: trabecular number	0.7	1.1	2.0	-1.1	1.4	0.8	-1.2	1.4	-1.3	0.3	-1.1	-0.9	-0.7	-1.2	0.5
Bone: trabecular spacing	0.4	0.5	1.7	0.2	-0.5	0.2	0.4	-1.2	0.6	-1.0	0.9	0.6	0.3	1.3	0.1
Bone: trabecular thickness	0.4	0.5	1.6	0.6	0.2	-1.0	0.3	1.0	0.0	1.3	-0.4	-0.2	0.3	-1.2	-0.4
Bone: trabecular tissue density	1.5	2.2	4.8	1.3	-1.6	-0.8	1.6	-2.2	1.8	-0.4	1.4	1.4	1.3	1.9	-1.2
Water consumed over 24 hours	0.1	0.1	0.3	0.1	-0.0	-0.2	0.1	0.6	0.1	-0.4	0.4	0.3	0.4	-0.4	-0.1
Number of responses in last shaping day	1.1	1.2	2.9	-1.0	0.8	0.7	-1.2	1.7	-1.2	-0.1	-0.8	-1.2	-0.7	-1.3	1.2