Cers5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	isoform ratio	XM_006257374.5	0.54	0.28	7.7e-03	0.25	0.21	0.21	0.22	1.1e-04	4.0e-04	3.6e-04	2.9e-04
2	Eye	intron excision ratio	chr7_132750920_132754902	0.18	0.14	5.5e-03	0.27	0.17	0.22	0.26	4.2e-05	1.4e-03	2.6e-04	7.2e-05
3	Eye	intron excision ratio	chr7_132749729_132750790	0.15	0.12	9.7e-03	0.13	0.17	0.09	0.17	5.6e-03	1.5e-03	1.5e-02	1.5e-03
4	PL	intron excision ratio	chr7_132740215_132740977	0.02	0.02	5.8e-03	0.04	0.01	0.03	0.03	4.9e-05	1.5e-02	5.1e-04	2.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4
Bone: apparent density	7.3	12.6	16.4	4.1	-3.2	3.5	3.4
Area under the delay curve	0.8	0.9	1.7	0.8	-1.3	1.1	0.0
BMI with tail	4.8	16.6	22.6	4.7	-4.6	4.7	0.0
BMI without tail	1.1	3.2	5.0	2.1	-1.9	2.2	0.0
Body weight	4.8	21.1	30.2	5.2	-5.2	5.5	0.0
Weight adjusted by age	0.9	1.4	3.4	1.8	-1.1	1.0	0.0
Bone surface	9.3	17.0	20.7	4.6	-3.9	4.1	3.9
Bone volume	8.0	14.3	15.3	3.9	-3.5	3.9	3.8
Breakpoint value in progressive ratio session	0.9	1.1	2.0	1.4	-1.2	0.9	0.0
Number of licking bursts	1.0	1.6	2.6	-0.8	1.6	-1.2	-1.3
Context. condit. distance diff. score	0.1	0.2	0.3	0.5	-0.2	0.5	0.3
Locomotion velocity, session 1	3.0	3.2	4.7	-0.8	1.9	-2.0	-2.2
Locomotion distance, session 1	2.7	3.4	3.8	-1.6	1.9	-1.9	-2.0
Locomotion velocity, session 2	0.2	0.3	0.4	-0.4	0.4	-0.6	-0.6
Locomotion distance, session 2	2.5	3.4	4.3	-1.7	1.7	-2.1	-2.0
Locomotion velocity, session 3	5.1	5.8	6.4	-2.2	2.5	-2.4	-2.5
Locomotion distance, session 3	3.8	4.2	5.8	-2.4	1.9	-1.9	-1.9
Stereotopy head waving bouts, day 3	0.3	0.3	1.1	1.0	-0.3	0.2	0.0
Stereotopy head waving duration, day 3	0.2	0.2	0.7	0.8	-0.2	-0.0	-0.2
Locomotion velocity, session 7	2.0	2.2	3.0	-0.6	1.6	-1.7	-1.7
Locomotion distance, session 7	3.2	4.0	4.8	-1.6	2.1	-2.2	-2.1
Stereotopy head waving bouts, day 7	0.8	0.9	1.2	1.1	-0.8	1.0	0.9
Stereotopy head waving duration, day 7	1.0	1.2	1.3	1.1	-1.0	1.1	1.1
Locomotion velocity, session 8	0.3	0.4	0.7	0.2	0.8	-0.6	-0.6
Locomotion distance, session 8	1.2	1.7	2.0	-1.2	1.4	-1.3	-1.3
Degree of sensitization distance	0.1	0.1	0.4	0.6	-0.3	0.1	0.2
Degree of sensitization stereotypy	0.4	0.4	0.6	0.2	-0.6	0.8	0.8
Conditioned locomotion	0.1	0.1	0.2	0.0	0.5	-0.2	-0.2
Cocaine response after cond. corrected	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1
Cocaine response after cond. not corrected	0.3	0.4	0.6	-0.8	0.6	-0.6	-0.5
Cocaine response before conditioning	2.8	3.4	4.3	-2.1	1.8	-1.6	-1.8
Saline control response	0.0	0.1	0.1	0.2	0.3	-0.1	-0.2
Bone: connectivity density	4.2	6.6	10.4	3.2	-2.2	2.4	2.3
Bone: cortical apparent density	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.1
Bone: cortical area	7.5	11.5	16.0	4.0	-3.2	3.3	3.0
Bone: cortical porosity	0.1	0.1	0.5	-0.7	0.1	0.1	0.1
Bone: cortical porosity	0.2	0.2	0.8	-0.9	0.3	-0.1	0.0
Bone: cortical thickness	2.3	3.9	5.9	2.4	-1.7	1.9	1.8
Bone: cortical thickness	0.1	0.1	0.2	0.1	0.0	-0.4	-0.4
Bone: cortical tissue density	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.2	0.5	-0.3	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.7	-0.2	0.4	0.4
Condit. Reinf. active responses	0.7	0.8	0.9	-0.8	1.0	-1.0	-0.9
Condit. Reinf. inactive responses	2.8	3.4	3.8	-2.0	1.7	-1.9	-1.9
Incentive salience index mean	0.0	0.0	0.0	0.1	0.2	0.1	0.1
Condit. Reinf. lever presses	0.3	0.4	0.5	0.3	-0.6	0.7	0.7
Condit. Reinf. active minus inactive responses	0.4	0.5	1.0	-0.1	-0.5	0.9	1.0
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	-0.5	-0.4	0.7	0.9
Condit. Reinf. active responses	0.1	0.1	0.2	-0.5	-0.1	0.2	0.3
Condit. Reinf. inactive responses	0.6	0.8	1.0	-0.8	0.8	-0.9	-1.0
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	0.0	0.0	-0.1
Condit. Reinf. lever reinforcers received	0.1	0.2	0.6	-0.8	0.4	-0.2	-0.1
Conditioned reinforcement - actives	0.5	0.8	1.9	-1.4	0.6	-0.9	0.0
Conditioned reinforcement - inactives	3.1	4.6	6.6	-2.6	2.3	-2.5	0.0
Conditioned locomotion	0.2	0.2	0.4	-0.4	0.6	-0.5	0.0
Patch foraging indifference point 0 sec	4.8	8.8	12.6	-2.1	3.5	-3.1	-3.0
Patch foraging indifference point AUC	0.7	1.0	1.5	-1.2	1.0	-1.0	-0.6
Delay disc. indifference point, 0s delay	1.2	1.3	2.2	1.1	-1.3	1.5	0.0
Delay disc. indifference point, 16s delay	0.7	0.8	1.7	0.8	-1.3	0.9	0.0
Delay disc. indifference point, 2s delay	1.2	1.4	2.1	1.2	-1.4	1.4	0.0
Delay disc. indifference point, 24s delay	0.5	0.6	1.0	1.0	-0.9	0.7	0.0
Delay disc. indifference point, 4s delay	0.9	0.9	2.0	0.6	-1.4	1.1	0.0
Delay disc. indifference point, 8s delay	1.1	1.3	2.0	1.4	-1.4	1.2	0.0
Indifference point function ln k	3.6	6.3	7.0	2.3	-2.5	2.6	2.6
Indifference point function log k	3.6	6.3	7.0	2.3	-2.5	2.6	2.6
Patch foraging total patch changes 0 sec	4.3	8.2	11.6	-2.0	3.4	-3.0	-2.8
Patch foraging total patch changes 12 sec	5.2	6.8	8.4	-2.0	2.7	-2.9	-2.7
Patch foraging total patch changes 18 sec	5.4	8.2	11.7	-2.6	3.4	-3.1	-2.2
Patch foraging total patch changes 24 sec	2.8	4.8	6.0	-1.9	2.4	-2.4	-1.9
Patch foraging total patch changes 6 sec	5.9	9.0	11.4	-2.1	3.4	-3.2	-3.1
Patch foraging time to switch 0 sec	2.0	4.0	4.3	-2.0	2.0	-2.1	-2.0
Patch foraging water rate 0 sec	2.7	5.6	6.4	2.2	-2.4	2.5	2.3
Patch foraging water rate 12 sec	2.4	5.0	5.6	2.4	-2.2	2.1	2.2
Patch foraging water rate 18 sec	0.4	0.7	0.9	0.8	-0.9	0.8	0.6
Patch foraging water rate 24 sec	4.1	5.7	7.0	2.2	-2.4	2.6	2.2
Patch foraging water rate 6 sec	6.1	8.8	10.1	2.5	-3.2	3.0	3.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	0.2	-0.5	0.7	0.0
Distance traveled before self-admin	1.4	1.9	3.9	-0.9	2.0	-1.6	0.0
Distance traveled after self-admin	0.8	1.0	2.3	-0.4	1.5	-1.2	0.0
Extensor digitorum longus weight	4.6	18.1	20.6	3.9	-4.5	4.4	4.2
Bone: elastic displacement	5.2	6.0	7.3	-1.9	2.5	-2.7	-2.6
Bone: elastic work	0.0	0.1	0.2	0.4	0.0	-0.1	-0.2
Bone: endosteal estimation	7.3	16.1	18.3	4.3	-4.1	4.1	3.5
Bone: endosteal perimeter	6.8	14.5	15.3	3.8	-3.9	3.8	3.7
Epididymis fat weight	0.4	1.2	2.7	1.7	-1.1	1.0	0.0
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	-0.1	0.1	0.0
Delta time in open arm before/after self-admin	1.0	1.0	1.5	-1.0	1.2	-1.1	0.0
Diff in mean of infusions in LGA sessions	0.8	0.9	1.5	1.2	-1.2	0.9	0.0
Delay discount exponential model param	0.8	0.9	1.8	-0.8	1.4	-1.0	0.0
Extinction: sum of active levers before priming	1.6	1.7	2.6	1.5	-1.4	1.6	0.0
Active lever presses in extinction session 6	0.4	0.4	1.3	1.1	-0.4	0.3	0.0
Bone: final force	11.5	18.3	19.1	4.3	-4.3	4.4	4.2
Bone: final moment	12.8	20.6	21.5	4.5	-4.5	4.6	4.4
Food consumed during 24 hour testing period	1.2	1.6	2.1	1.4	-0.9	1.5	1.3
Glucose	0.1	0.2	0.5	0.3	0.6	-0.7	0.0
Heart weight	0.1	0.2	0.3	0.1	-0.6	0.5	0.0
Delay discount hyperbolic model param	0.8	0.9	1.8	-0.8	1.3	-1.0	0.0
Intermittent access intake day 1-15 change	0.1	0.2	0.4	-0.5	-0.6	0.3	0.0
Intermittent access intake escalation	0.2	0.4	0.9	-0.3	-1.0	0.7	0.0
Intermittent access intake escalation 2	0.1	0.1	0.4	-0.6	-0.4	0.2	0.0
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.6	-0.8	0.4	-0.3	0.0
Intermitt. access day 15 inactive lever presses	0.2	0.4	1.4	-1.2	-0.1	-0.0	0.0
Intermitt. access escalation Index	0.1	0.2	0.7	0.8	-0.1	0.3	0.0
Intermittent access day 1 total infusions	0.8	1.4	2.3	-1.2	1.5	-1.3	0.0
Intermittent access day 15 total infusions	0.5	0.7	1.8	-1.3	0.7	-0.9	0.0
Intermittent access terminal intake (last 3 days)	0.8	1.0	2.3	-1.5	0.8	-1.0	0.0
Intermittent access total infusions	1.3	1.6	3.1	-1.7	1.2	-1.3	0.0
Intermittent access day 1 locomotion	0.4	0.6	1.2	-0.3	1.1	-1.0	0.0
Intermittent access day 15 total locomotion	0.2	0.4	0.7	-0.5	0.8	-0.7	0.0
Intermittent access total locomotion	1.6	1.9	3.2	-1.3	1.8	-1.6	0.0
Intermittent access standard deviation	0.1	0.2	0.7	-0.9	0.0	-0.4	0.0
Left kidney weight	1.0	4.5	7.9	1.8	-2.8	2.6	0.0
Right kidney weight	3.4	15.3	23.3	4.2	-4.8	4.5	0.0
Cocaine induced anxiety	1.7	2.4	3.8	1.9	-1.7	1.7	0.0
Post-drug Anxiety	2.6	2.8	4.0	1.9	-1.9	2.0	0.0
Baseline Anxiety	0.1	0.1	0.3	0.1	-0.4	0.6	0.0
Tail length	0.0	0.0	0.1	-0.1	0.3	-0.0	0.0
Length with tail	1.1	4.6	6.8	2.5	-2.4	2.6	0.0
Length without tail	4.2	13.6	18.6	4.3	-4.2	4.3	0.0
Times rat made contact with spout	0.1	0.1	0.3	-0.4	0.5	-0.1	-0.1
Lifetime Intake	2.0	2.4	4.2	-2.0	1.6	-1.7	0.0
Liver weight, left	7.3	12.1	17.3	3.9	-4.0	4.2	0.0
Liver weight, right	2.2	3.9	5.9	2.1	-2.2	2.4	0.0
Locomotor activity	1.5	2.3	3.1	-1.3	1.6	-1.4	-1.8
Locomotor testing distance	3.2	5.9	6.4	-2.2	2.5	-2.4	-2.5
Locomotor testing rearing	2.1	4.1	4.5	-1.9	2.1	-1.9	-2.1
Locomotion in novel chamber	2.3	3.0	5.5	1.3	-2.2	2.3	0.0
Locomotion in novel chamber post-restriction	0.0	0.1	0.2	-0.1	-0.3	0.5	0.0
Fecal boli incidents, locomotor time 1	0.8	1.2	2.5	-1.6	1.0	-1.1	0.0
Change in fecal boli incidents, locomotor task	0.4	0.4	1.2	1.1	-0.3	0.4	0.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.4	0.2	0.4	-0.6	0.0
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.1	-0.2	-0.0	0.0
Total resting periods, locomotor time 1	0.2	0.2	0.4	-0.4	0.4	-0.7	0.0
Rest time, locomotor task time 1	0.4	0.5	0.9	-0.6	0.9	-0.9	0.0
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.1	0.1	-0.0	0.0
Vertical activity count, locomotor time 1	0.3	0.8	1.1	1.0	-1.0	1.1	0.0
Time >=10cm from walls, locomotor time 2	0.3	0.4	1.0	-1.0	0.5	-0.7	0.0
Bouts of movement, locomotor time 2	1.7	2.7	4.4	1.8	-1.7	2.1	0.0
Total resting periods, locomotor time 2	1.7	2.9	4.9	1.9	-1.7	2.2	0.0
Rest time, locomotor task time 2	0.2	0.2	0.6	0.1	0.8	-0.4	0.0
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.0
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.0	-0.5	0.4	0.0
Light reinforcement 1	1.2	3.0	5.6	-2.4	1.8	-1.5	-1.0
Light reinforcement 2	0.3	0.5	1.4	-1.2	0.3	-0.1	0.6
Bone: marrow area	7.0	15.2	17.9	4.2	-4.0	3.9	3.4
Bone: maximum diameter	2.3	4.3	6.3	2.5	-2.1	1.8	1.7
Bone: maximum force	15.3	27.1	30.4	5.5	-5.2	5.2	4.8
Bone: maximum moment	17.0	29.7	32.7	5.7	-5.4	5.5	5.1
Mean time between licks in bursts	0.0	0.1	0.1	-0.3	0.3	-0.3	-0.3
Mean num. licks in bursts	0.3	0.5	0.8	0.2	-0.9	0.7	0.9
Cd content in liver	0.5	0.5	0.7	-0.8	0.7	-0.5	-0.7
Co content in liver	0.4	0.4	0.5	-0.7	0.6	-0.6	-0.6
Cu content in liver	0.4	0.4	1.5	1.2	0.0	0.4	-0.2
Fe content in liver	1.7	2.1	2.3	-1.5	1.4	-1.5	-1.4
K content in liver	0.1	0.1	0.2	0.1	0.1	-0.4	-0.3
Mg content in liver	0.3	0.3	0.7	-0.4	0.8	-0.4	-0.2
Mn content in liver	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1
Na content in liver	0.0	0.0	0.2	-0.1	-0.0	-0.0	0.4
Rb content in liver	1.4	1.6	2.8	-0.1	1.7	-1.2	-1.5
Se content in liver	3.2	3.8	4.6	-1.5	2.1	-2.1	-2.0
Sr content in liver	0.6	0.6	1.2	1.1	-0.0	0.8	0.7
Zn content in liver	1.1	1.2	2.0	-1.1	1.4	-1.0	-0.9
Bone: minimum diameter	8.6	15.6	17.6	4.2	-3.8	4.0	3.8
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.4	0.2	0.0	0.3
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.4	-0.1	0.2	-0.1
Total zone transitions, hab. session 1	0.1	0.1	0.4	-0.6	0.2	-0.3	-0.1
Total locomotion distance, hab. session 1	0.2	0.2	0.4	0.2	0.5	-0.6	-0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.3	0.4	-0.4	-0.4
Time in familiar zone, hab. session 2	1.3	1.3	2.0	0.7	-1.1	1.3	1.4
Time in novel zone, hab. session 2	1.4	1.4	2.2	-0.5	1.3	-1.3	-1.5
Total zone transitions, hab. session 2	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.4
Total locomotion distance, hab. session 2	0.2	0.3	0.5	-0.1	0.7	-0.7	-0.6
Locomotion velocity, hab. session 2	0.1	0.2	0.3	-0.0	0.6	-0.5	-0.4
Novel to familiar place preference ratio	1.3	1.4	2.0	1.4	-0.8	1.2	1.2
Novelty place preference	0.8	0.9	1.5	1.2	-0.5	1.0	0.9
Time in novel zone, NPP test	0.6	0.7	1.3	1.1	-0.3	0.8	0.8
Total zone transitions, NPP test	2.2	3.2	3.8	-1.3	2.0	-1.9	-1.9
Total locomotion distance, NPP test	3.0	4.0	4.9	-1.4	2.2	-2.2	-2.2
Locomotion velocity, NPP test	1.9	2.6	3.4	-1.0	1.8	-1.8	-1.8
Intraocular pressure	6.4	9.2	11.1	-3.3	3.3	-2.9	-2.5
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.1	-0.1	0.1	0.0
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	-0.3	0.0	-0.1	0.0
Parametrial fat weight	0.6	1.4	3.0	-1.7	1.2	-1.2	0.0
Pavlov. Cond. lever latency	0.2	0.2	0.5	0.7	0.4	-0.3	-0.4
Pavlov. Cond. magazine entry latency	0.7	0.9	1.5	-0.1	-1.2	1.0	1.0
Pavlov. Cond. change in total contacts	1.0	1.0	1.7	-0.1	-1.3	1.1	1.1
Pavlov. Cond. index score	0.6	0.7	1.3	-0.2	-1.1	0.9	0.9
Pavlov. Cond. latency score	0.5	0.6	0.9	-0.3	-1.0	0.8	0.9
Pavlov. Cond. lever contacts	0.3	0.3	1.0	-1.0	-0.4	0.2	0.3
Pavlov. Cond. magazine entry number	0.3	0.4	0.9	0.1	0.9	-0.7	-0.5
Pavlov. Cond. intertrial magazine entries	3.3	3.9	5.9	-0.5	2.1	-2.3	-2.4
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.9	0.1	-1.4	1.1	1.1
Pavlov. Cond. response bias	0.2	0.3	0.5	-0.5	-0.7	0.4	0.4
Pavlov. Cond. lever latency	0.7	1.0	1.3	0.4	-1.1	1.1	1.2
Pavlov. Cond. magazine entry latency	0.4	0.4	1.4	1.2	0.1	-0.2	-0.5
Pavlov. Cond. change in total contacts	0.6	0.9	2.1	1.4	-0.6	0.9	0.7
Pavlov. Cond. index score	0.3	0.4	0.8	0.9	0.4	-0.4	-0.7
Pavlov. Cond. latency score	0.3	0.4	0.7	0.8	0.5	-0.5	-0.8
Pavlov. Cond. lever contacts	0.5	0.7	1.0	-0.2	1.0	-0.9	-1.0
Pavlov. Cond. magazine entry number	0.6	0.8	2.9	-1.7	0.3	-0.2	0.1
Pavlov. Cond. intertrial magazine entries	3.3	4.9	9.1	-3.0	2.0	-1.9	-1.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.1	1.1	0.3	-0.3	-0.6
Pavlov. Cond. response bias	0.2	0.3	0.5	0.3	0.6	-0.6	-0.7
Time in closed arm before self-admin	1.4	1.8	3.4	1.8	-1.4	1.4	0.0
Time in closed arm after self-admin	0.2	0.2	0.5	0.4	-0.7	0.5	0.0
Time in open arm before self-admin	0.2	0.2	0.5	-0.3	0.7	-0.6	0.0
Time in open arm after self-admin	0.2	0.2	0.5	-0.2	0.7	-0.5	0.0
Bone: periosteal estimation	10.5	22.0	26.8	5.2	-4.7	4.7	4.2
Bone: periosteal perimeter	9.6	16.5	18.6	4.3	-4.1	4.1	3.8
Bone: post-yield work	8.2	12.0	14.1	3.8	-3.6	3.4	3.1
Progressive ratio test 1 active lever presses	5.4	6.6	9.2	-2.9	3.0	-3.0	0.0
Progressive ratio test 1 breakpoint	5.1	6.3	8.8	-2.8	2.9	-3.0	0.0
Progressive ratio test 1 inactive lever presses	0.8	1.2	3.3	-1.8	0.9	-0.9	0.0
Progressive ratio test 2 active lever presses	1.4	1.7	3.2	-1.8	1.2	-1.4	0.0
Progressive ratio test 2 breakpoint	1.3	1.5	3.0	-1.7	1.2	-1.3	0.0
Progressive ratio test 2 inactive lever presses	0.6	0.9	2.5	-1.6	0.7	-0.9	0.0
Incentive Sensitization - Responses	0.3	0.4	0.7	0.2	-0.8	0.8	0.0
Incentive Sensitization - Breakpoint	0.2	0.3	0.5	0.1	-0.7	0.7	0.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.3	0.3	-0.2	0.0
Progressive ratio	0.7	1.1	2.0	-0.7	1.4	-1.4	0.0
Food seeking constrained by brief footshock	1.6	2.0	3.6	-1.0	1.8	-1.9	0.0
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.1	-0.2	0.2	0.0
Retroperitoneal fat weight	0.4	1.5	3.4	-1.1	1.3	-1.8	0.0
Reaction time number correct	1.2	2.2	3.0	1.6	-1.3	1.3	1.7
Reaction time mean minus median	3.6	9.0	11.6	-3.4	2.9	-2.9	-2.8
Reaction time mean minus median AUC	2.5	6.3	8.0	-2.8	2.5	-2.4	-2.3
Reaction time num false alarms	1.7	2.3	3.6	-1.5	1.9	-1.4	-1.3
Reaction time num false alarms AUC	1.9	2.9	4.1	-1.7	2.0	-1.5	-1.5
Reaction time trials correct on left	1.2	2.2	3.0	1.6	-1.3	1.3	1.7
Reaction time trials on left	0.9	1.8	2.5	1.4	-1.1	1.1	1.6
Reaction time mean	0.8	1.2	1.6	-1.2	1.1	-1.0	-1.0
Reaction time mean AUC	0.5	0.8	1.0	-1.0	1.0	-0.8	-0.8
Median of all reaction times	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.2
Reaction time omissions	8.3	12.1	14.6	-3.8	3.3	-3.5	-3.3
Reaction time false alarm rate	2.5	3.4	4.1	-2.0	2.0	-1.6	-1.8
Reaction time premature initiation rate	4.2	5.8	7.8	-2.8	2.0	-2.3	-2.5
Reaction time premature initiations	1.3	2.2	3.3	-1.8	1.1	-1.5	-1.5
Std. dev. reaction times	4.5	8.3	9.7	-3.1	2.9	-2.7	-2.7
Reaction time trials completed	0.9	1.8	2.5	1.4	-1.1	1.1	1.6
Reaction time trials AUC	1.5	2.9	3.8	1.8	-1.5	1.5	2.0
Run reversals in cocaine runway, females	0.3	0.3	0.5	0.2	-0.7	0.7	0.0
Run reversals in cocaine runway, males	0.6	0.6	1.2	-1.1	0.8	-0.8	0.0
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.3	-0.2	-0.0	0.0
Latency to leave start box in cocaine runway, F	0.7	0.8	1.4	-1.2	0.7	-1.0	0.0
Latency to leave start box in cocaine runway, M	1.4	1.3	1.8	1.2	-1.3	1.4	0.0
Std. dev. time between licks in bursts	1.2	1.7	2.0	-1.3	1.4	-1.3	-1.2
Total sessions with >9 infusions	2.1	2.5	4.4	-2.1	1.6	-1.7	0.0
Short access day 1 total inactive lever presses	1.4	1.8	3.0	-1.7	1.5	-1.5	0.0
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.1	0.2	0.3	0.0
Short access day 1 total infusions	0.9	1.2	1.7	-1.2	1.3	-1.3	0.0
Short access day 10 total infusions	1.5	1.9	2.9	-1.7	1.6	-1.6	0.0
Short access total infusions	2.8	3.5	4.9	-2.2	2.2	-2.2	0.0
Short access day 1 locomotion	0.3	0.4	0.7	-0.6	0.9	-0.7	0.0
Short access day 10 total locomotion	0.2	0.3	0.5	-0.5	0.7	-0.7	0.0
Short access total locomotion	0.9	1.0	1.7	-1.1	1.3	-1.1	0.0
One hour access (0.3 mA shock)	0.2	0.3	0.5	-0.7	-0.7	0.4	0.0
Compulsive drug intake	0.2	0.2	0.6	-0.1	-0.8	0.6	0.0
One hour access (shock baseline)	0.1	0.1	0.3	-0.2	-0.5	0.4	0.0
Social response proportion	0.3	0.3	0.8	-0.3	0.6	-0.4	-0.9
Social responses	6.6	8.6	9.8	-3.0	2.9	-2.6	-3.1
Social time	0.2	0.3	0.7	0.3	-0.8	0.7	0.2
Soleus weight	1.0	2.9	3.6	1.4	-1.9	1.6	1.9
Bone: stiffness	19.3	31.4	33.4	5.5	-5.6	5.8	5.5
Tibialis anterior weight	2.1	7.2	9.4	1.5	-3.1	3.0	2.8
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.5	-1.2	1.1	-1.2	0.0
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.9	0.4	-0.9	0.5	0.0
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.4	0.4	-0.4	0.0
Time to tail flick, test, after self-admin	0.7	0.8	1.2	0.9	-1.0	1.1	0.0
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.9	0.7	-1.0	0.8	0.0
Delta time to tail flick, test, before/after SA	0.3	0.3	0.6	0.5	-0.6	0.8	0.0
Tibia length	4.9	13.5	19.4	4.4	-3.3	3.7	3.2
Ambulatory time before self-admin	1.7	2.6	4.6	-1.4	2.2	-1.9	0.0
Ambulatory time after self-admin	1.4	1.7	3.2	-1.2	1.8	-1.5	0.0
Bone: tissue strength	1.5	1.5	1.8	1.3	-1.2	1.3	1.0
Total heroin consumption	0.5	0.6	1.2	1.1	-0.7	0.8	0.0
Bone: trabecular number	4.4	7.2	10.4	3.2	-2.3	2.6	2.5
Bone: trabecular spacing	1.6	2.1	3.7	-1.9	1.2	-1.3	-1.2
Bone: trabecular thickness	0.3	0.3	0.8	-0.3	-0.4	0.6	0.9
Bone: trabecular tissue density	0.5	0.7	1.3	-0.1	-0.5	1.0	1.1
Water consumed over 24 hours	0.1	0.1	0.1	0.4	0.4	0.1	-0.0
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	0.3	0.1	0.0