Hub : Genes

Cers5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	intron excision ratio	chr7_130870888_130876061	0.12	0.1	5.0e-03	0.02	0.09	0.01	0.07	7.4e-02	2.3e-03	1.2e-01	6.8e-03
2	Eye	intron excision ratio	chr7_130872079_130876061	0.17	0.14	9.2e-03	0.25	0.15	0.18	0.23	8.4e-05	2.7e-03	1.0e-03	1.6e-04
3	PL	intron excision ratio	chr7_130861374_130862136	0.02	0.02	5.3e-03	0.01	0.01	0.01	0.01	2.2e-02	3.1e-02	2.1e-02	3.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	7.4	12.4	12.8	-3.6	3.5	-3.4
Area under the delay curve	1.4	1.5	1.7	-1.1	1.2	-1.3
BMI with tail	4.3	13.8	14.2	-3.8	3.7	-3.7
BMI without tail	0.2	0.4	0.6	-0.6	0.6	-0.8
Body weight	5.4	22.5	25.9	-4.6	5.1	-4.5
Weight adjusted by age	0.5	0.5	1.0	-0.6	1.0	-0.4
Bone surface	9.7	17.0	18.0	-4.2	4.1	-4.1
Bone volume	8.9	15.2	15.7	-4.0	3.9	-3.9
Breakpoint value in progressive ratio session	0.2	0.2	0.5	-0.2	0.7	-0.4
Number of licking bursts	1.5	1.8	2.7	1.2	-1.6	1.2
Context. condit. distance diff. score	0.2	0.2	0.3	-0.5	0.5	-0.5
Locomotion velocity, session 1	3.7	4.0	4.3	2.1	-1.9	2.1
Locomotion distance, session 1	2.8	3.6	3.7	1.9	-1.9	1.9
Locomotion velocity, session 2	0.3	0.3	0.4	0.6	-0.6	0.6
Locomotion distance, session 2	3.0	4.2	4.3	2.1	-2.1	2.0
Locomotion velocity, session 3	4.7	5.5	5.8	2.4	-2.4	2.3
Locomotion distance, session 3	2.9	3.2	3.5	1.9	-1.7	1.8
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	-0.1	0.2	-0.1
Stereotopy head waving duration, day 3	0.0	0.0	0.0	0.1	-0.1	0.1
Locomotion velocity, session 7	2.4	2.7	3.2	1.8	-1.3	1.8
Locomotion distance, session 7	3.7	4.7	5.3	2.3	-1.9	2.3
Stereotopy head waving bouts, day 7	0.5	0.6	0.6	-0.8	0.8	-0.8
Stereotopy head waving duration, day 7	1.1	1.3	1.3	-1.1	1.1	-1.1
Locomotion velocity, session 8	0.5	0.6	0.7	0.7	-0.7	0.8
Locomotion distance, session 8	1.2	1.7	1.8	1.3	-1.3	1.3
Degree of sensitization distance	0.0	0.0	0.0	-0.1	0.1	-0.1
Degree of sensitization stereotypy	0.6	0.7	0.7	-0.8	0.8	-0.8
Conditioned locomotion	0.1	0.1	0.2	0.1	-0.4	0.2
Cocaine response after cond. corrected	0.0	0.0	0.1	-0.0	0.4	0.0
Cocaine response after cond. not corrected	0.2	0.2	0.2	0.5	-0.3	0.4
Cocaine response before conditioning	2.3	2.8	3.6	1.6	-1.9	1.4
Saline control response	0.1	0.1	0.2	0.0	-0.5	0.2
Bone: connectivity density	3.8	6.0	6.5	-2.5	2.4	-2.4
Bone: cortical apparent density	0.1	0.2	0.3	0.6	-0.2	0.5
Bone: cortical area	5.9	8.9	9.3	-3.1	3.0	-2.9
Bone: cortical porosity	0.0	0.0	0.0	-0.2	-0.0	-0.2
Bone: cortical porosity	0.0	0.0	0.1	0.1	-0.3	0.1
Bone: cortical thickness	1.5	2.5	2.6	-1.6	1.6	-1.6
Bone: cortical thickness	0.3	0.3	0.4	0.5	-0.6	0.6
Bone: cortical tissue density	0.2	0.3	0.4	0.7	-0.3	0.6
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.3	-0.2	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.4	0.3	-0.4
Condit. Reinf. active responses	0.7	0.9	0.9	1.0	-0.9	0.9
Condit. Reinf. inactive responses	2.8	3.3	3.5	1.9	-1.7	1.8
Incentive salience index mean	0.0	0.0	0.0	-0.1	0.1	-0.1
Condit. Reinf. lever presses	0.5	0.7	0.8	-0.8	0.9	-0.8
Condit. Reinf. active minus inactive responses	0.6	0.8	1.1	-1.0	0.4	-1.1
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.8	-0.8	0.3	-0.9
Condit. Reinf. active responses	0.1	0.1	0.1	-0.3	-0.0	-0.4
Condit. Reinf. inactive responses	0.6	0.8	1.0	1.0	-0.7	0.9
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.0	-0.3	0.0
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	0.1	-0.6	0.1
Conditioned reinforcement - actives	1.0	1.0	1.2	1.1	-0.9	1.0
Conditioned reinforcement - inactives	2.0	2.2	2.3	1.5	-1.5	1.5
Conditioned locomotion	0.2	0.2	0.3	0.4	-0.5	0.4
Patch foraging indifference point 0 sec	6.0	9.6	10.3	3.1	-3.0	3.2
Patch foraging indifference point AUC	0.4	0.4	0.7	0.5	-0.9	0.6
Delay disc. indifference point, 0s delay	1.9	2.1	2.2	-1.5	1.4	-1.4
Delay disc. indifference point, 16s delay	1.2	1.2	1.4	-1.0	1.2	-1.1
Delay disc. indifference point, 2s delay	1.9	2.1	2.4	-1.5	1.5	-1.3
Delay disc. indifference point, 24s delay	0.7	0.7	0.8	-0.8	0.9	-0.8
Delay disc. indifference point, 4s delay	1.3	1.3	1.6	-1.1	1.1	-1.2
Delay disc. indifference point, 8s delay	1.9	2.0	2.3	-1.3	1.4	-1.5
Indifference point function ln k	5.2	7.2	7.8	-2.7	2.8	-2.6
Indifference point function log k	5.2	7.2	7.8	-2.7	2.8	-2.6
Patch foraging total patch changes 0 sec	5.6	9.0	9.5	3.0	-2.9	3.1
Patch foraging total patch changes 12 sec	5.8	7.5	8.1	2.8	-2.6	2.8
Patch foraging total patch changes 18 sec	7.8	10.0	10.7	3.1	-3.3	3.1
Patch foraging total patch changes 24 sec	4.8	5.9	6.3	2.3	-2.5	2.4
Patch foraging total patch changes 6 sec	6.9	10.2	10.8	3.2	-3.1	3.3
Patch foraging time to switch 0 sec	2.1	3.3	3.9	2.0	-1.7	1.8
Patch foraging water rate 0 sec	3.1	4.9	5.3	-2.3	2.1	-2.2
Patch foraging water rate 12 sec	2.5	3.8	4.4	-2.1	1.6	-2.0
Patch foraging water rate 18 sec	0.5	0.7	0.8	-0.8	0.9	-0.8
Patch foraging water rate 24 sec	4.6	6.4	7.2	-2.6	2.4	-2.7
Patch foraging water rate 6 sec	5.5	8.1	8.3	-2.9	2.8	-2.9
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.8	-0.9	0.3	-0.8
Distance traveled before self-admin	2.1	2.3	2.8	1.6	-1.1	1.7
Distance traveled after self-admin	0.5	0.5	0.7	0.8	-0.4	0.8
Extensor digitorum longus weight	4.8	18.9	19.7	-4.3	4.4	-4.3
Bone: elastic displacement	6.6	7.5	7.8	2.8	-2.7	2.8
Bone: elastic work	0.0	0.0	0.1	0.0	0.3	0.0
Bone: endosteal estimation	7.1	15.6	16.8	-4.1	3.8	-3.9
Bone: endosteal perimeter	6.4	13.4	14.6	-3.8	3.4	-3.7
Epididymis fat weight	0.0	0.0	0.0	-0.1	0.2	-0.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.3	0.3	-0.2
Delta time in open arm before/after self-admin	4.3	4.1	5.2	1.9	-2.3	1.9
Diff in mean of infusions in LGA sessions	2.0	2.2	2.7	-1.3	1.6	-1.5
Delay discount exponential model param	1.4	1.4	1.6	1.1	-1.2	1.3
Extinction: sum of active levers before priming	0.8	0.8	1.0	-0.9	1.0	-0.8
Active lever presses in extinction session 6	0.2	0.1	0.3	-0.3	0.6	-0.3
Bone: final force	10.7	17.3	17.9	-4.2	4.1	-4.1
Bone: final moment	12.1	19.7	20.4	-4.5	4.4	-4.4
Food consumed during 24 hour testing period	1.5	1.8	2.1	-1.4	1.3	-1.3
Glucose	0.4	0.7	1.1	0.6	-1.0	0.7
Heart weight	0.1	0.2	0.2	-0.3	0.4	-0.4
Delay discount hyperbolic model param	1.4	1.5	1.7	1.1	-1.2	1.3
Intermittent access intake day 1-15 change	0.2	0.2	0.2	0.5	-0.5	0.2
Intermittent access intake escalation	0.0	0.0	0.0	0.2	-0.1	-0.1
Intermittent access intake escalation 2	0.1	0.1	0.2	0.4	-0.4	0.2
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.4	0.6	-0.6	0.6
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.1	0.3	-0.2	0.2
Intermitt. access escalation Index	0.8	0.7	0.8	0.8	-0.9	0.8
Intermittent access day 1 total infusions	1.2	1.4	1.5	1.2	-1.1	1.2
Intermittent access day 15 total infusions	1.6	1.8	2.1	1.4	-1.3	1.2
Intermittent access terminal intake (last 3 days)	1.6	1.8	2.0	1.4	-1.3	1.2
Intermittent access total infusions	1.6	1.8	2.0	1.4	-1.3	1.3
Intermittent access day 1 locomotion	1.3	1.4	1.5	1.2	-1.1	1.2
Intermittent access day 15 total locomotion	1.1	1.2	1.4	1.1	-1.2	1.0
Intermittent access total locomotion	3.9	4.4	4.5	2.1	-2.1	2.0
Intermittent access standard deviation	0.0	0.0	0.0	0.0	0.1	-0.1
Left kidney weight	1.3	3.6	5.1	-1.6	2.3	-1.7
Right kidney weight	2.6	7.4	9.4	-2.5	3.1	-2.6
Cocaine induced anxiety	1.2	1.3	1.6	-1.0	1.3	-1.2
Post-drug Anxiety	5.5	6.1	6.3	-2.4	2.5	-2.5
Baseline Anxiety	0.6	0.7	0.9	-0.9	0.9	-0.6
Tail length	0.0	0.0	0.0	0.2	0.1	0.0
Length with tail	1.9	7.0	8.8	-2.5	3.0	-2.5
Length without tail	5.1	11.2	12.8	-3.3	3.6	-3.1
Times rat made contact with spout	0.0	0.0	0.0	0.1	-0.1	0.2
Lifetime Intake	2.3	2.6	2.9	1.7	-1.5	1.6
Liver weight, left	1.4	2.2	2.7	-1.6	1.3	-1.4
Liver weight, right	1.5	2.5	2.8	-1.6	1.7	-1.5
Locomotor activity	0.8	1.2	1.9	1.4	-0.5	1.2
Locomotor testing distance	2.6	4.3	5.4	2.3	-1.7	2.1
Locomotor testing rearing	1.9	3.0	3.5	1.9	-1.5	1.8
Locomotion in novel chamber	2.3	2.8	3.4	-1.8	1.4	-1.8
Locomotion in novel chamber post-restriction	0.3	0.3	0.5	-0.7	0.7	-0.3
Fecal boli incidents, locomotor time 1	1.0	1.1	1.6	1.2	-1.3	0.7
Change in fecal boli incidents, locomotor task	0.4	0.4	0.5	-0.6	0.7	-0.5
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	0.5	-0.5	0.5
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.1	0.1	-0.2
Total resting periods, locomotor time 1	0.3	0.4	0.4	0.6	-0.6	0.6
Rest time, locomotor task time 1	0.6	0.7	0.8	0.9	-0.9	0.7
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.0	-0.0	0.1
Vertical activity count, locomotor time 1	1.1	1.2	1.3	-1.0	1.1	-1.2
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.4	0.6	-0.5	0.3
Bouts of movement, locomotor time 2	2.9	3.2	3.6	-1.9	1.8	-1.6
Total resting periods, locomotor time 2	3.3	3.6	4.1	-2.0	1.9	-1.7
Rest time, locomotor task time 2	0.2	0.2	0.3	0.3	-0.4	0.5
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.3	-0.0	0.1
Vertical activity count, locomotor time 2	0.2	0.2	0.3	-0.3	0.4	-0.5
Light reinforcement 1	0.9	1.6	2.0	1.3	-1.4	1.1
Light reinforcement 2	0.0	0.1	0.1	-0.0	0.3	-0.3
Bone: marrow area	6.7	14.5	15.7	-4.0	3.7	-3.8
Bone: maximum diameter	1.6	2.9	3.1	-1.8	1.7	-1.7
Bone: maximum force	14.4	24.8	25.4	-5.0	5.0	-4.9
Bone: maximum moment	16.1	27.7	28.4	-5.3	5.3	-5.2
Mean time between licks in bursts	0.0	0.0	0.0	0.1	0.2	0.1
Mean num. licks in bursts	0.7	0.8	1.5	-0.7	1.2	-0.7
Cd content in liver	0.6	0.6	0.8	0.7	-0.9	0.7
Co content in liver	0.4	0.5	0.7	0.8	-0.5	0.7
Cu content in liver	0.1	0.1	0.3	-0.5	0.3	-0.3
Fe content in liver	0.8	1.0	1.2	1.1	-0.8	1.1
K content in liver	0.1	0.1	0.2	0.3	-0.1	0.4
Mg content in liver	0.3	0.3	0.3	0.5	-0.5	0.5
Mn content in liver	0.1	0.1	0.2	-0.4	0.4	-0.2
Na content in liver	0.3	0.3	0.4	0.5	-0.5	0.6
Rb content in liver	2.3	2.9	3.0	1.6	-1.7	1.7
Se content in liver	2.4	2.9	3.2	1.6	-1.8	1.7
Sr content in liver	0.0	0.0	0.0	-0.1	-0.1	-0.2
Zn content in liver	2.7	3.0	3.2	1.8	-1.7	1.7
Bone: minimum diameter	8.1	15.2	16.3	-4.0	3.8	-3.8
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.0	0.0	-0.0
Time in novel zone, hab. session 1	0.0	0.0	0.0	-0.1	0.1	-0.1
Total zone transitions, hab. session 1	0.1	0.1	0.1	0.3	-0.4	0.3
Total locomotion distance, hab. session 1	0.3	0.4	0.4	0.6	-0.6	0.7
Locomotion velocity, hab. session 1	0.2	0.2	0.2	0.4	-0.5	0.5
Time in familiar zone, hab. session 2	1.4	1.5	1.6	-1.3	1.2	-1.2
Time in novel zone, hab. session 2	1.6	1.6	1.7	1.3	-1.3	1.3
Total zone transitions, hab. session 2	0.2	0.3	0.4	0.5	-0.6	0.6
Total locomotion distance, hab. session 2	0.4	0.6	0.7	0.7	-0.8	0.8
Locomotion velocity, hab. session 2	0.2	0.3	0.4	0.5	-0.6	0.6
Novel to familiar place preference ratio	1.3	1.3	1.6	-1.2	1.1	-1.2
Novelty place preference	0.7	0.7	0.9	-1.0	0.7	-0.9
Time in novel zone, NPP test	0.5	0.5	0.6	-0.8	0.5	-0.7
Total zone transitions, NPP test	2.5	3.6	3.8	1.9	-1.8	1.9
Total locomotion distance, NPP test	3.5	4.8	4.8	2.2	-2.2	2.2
Locomotion velocity, NPP test	2.3	3.2	3.3	1.8	-1.8	1.8
Intraocular pressure	5.1	7.1	7.4	2.7	-2.7	2.5
Delta distance traveled before/after self-admin	0.2	0.2	0.3	-0.5	0.2	-0.5
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.3	0.1	-0.4
Parametrial fat weight	1.4	2.6	3.0	1.6	-1.7	1.5
Pavlov. Cond. lever latency	0.1	0.2	0.2	0.3	-0.4	0.4
Pavlov. Cond. magazine entry latency	0.9	1.2	1.3	-1.1	1.1	-1.1
Pavlov. Cond. change in total contacts	1.2	1.3	1.4	-1.1	1.2	-1.1
Pavlov. Cond. index score	0.7	0.8	0.9	-0.9	0.9	-0.9
Pavlov. Cond. latency score	0.5	0.6	0.7	-0.7	0.8	-0.8
Pavlov. Cond. lever contacts	0.0	0.1	0.1	-0.1	0.3	-0.2
Pavlov. Cond. magazine entry number	0.3	0.4	0.4	0.6	-0.7	0.7
Pavlov. Cond. intertrial magazine entries	4.6	5.5	6.4	2.3	-2.2	2.5
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	1.3	-1.1	1.2	-1.1
Pavlov. Cond. response bias	0.3	0.3	0.4	-0.5	0.6	-0.6
Pavlov. Cond. lever latency	1.2	1.6	2.4	-1.0	1.5	-1.1
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	0.2	-0.6	0.3
Pavlov. Cond. change in total contacts	0.3	0.4	0.7	-0.8	0.3	-0.6
Pavlov. Cond. index score	0.6	0.8	1.5	0.6	-1.2	0.8
Pavlov. Cond. latency score	0.6	0.8	1.4	0.6	-1.2	0.7
Pavlov. Cond. lever contacts	1.1	1.5	2.4	1.0	-1.6	1.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.1	0.4	-0.1
Pavlov. Cond. intertrial magazine entries	1.9	2.5	3.0	1.7	-1.4	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	0.3	-0.9	0.5
Pavlov. Cond. response bias	0.6	0.9	1.6	0.7	-1.3	0.7
Time in closed arm before self-admin	1.0	1.2	1.3	-1.1	1.1	-1.0
Time in closed arm after self-admin	0.5	0.6	0.6	-0.7	0.8	-0.8
Time in open arm before self-admin	0.4	0.4	0.9	-0.3	1.0	-0.4
Time in open arm after self-admin	0.2	0.2	0.3	0.5	-0.4	0.6
Bone: periosteal estimation	9.3	19.2	20.3	-4.5	4.3	-4.3
Bone: periosteal perimeter	8.9	14.8	16.0	-4.0	3.7	-3.8
Bone: post-yield work	8.5	11.6	12.0	-3.5	3.3	-3.4
Progressive ratio test 1 active lever presses	8.2	8.5	8.9	3.0	-2.9	2.9
Progressive ratio test 1 breakpoint	7.0	7.3	7.6	2.8	-2.7	2.7
Progressive ratio test 1 inactive lever presses	2.2	2.4	2.6	1.6	-1.5	1.6
Progressive ratio test 2 active lever presses	2.1	2.2	2.3	1.5	-1.5	1.5
Progressive ratio test 2 breakpoint	2.4	2.7	2.8	1.6	-1.7	1.7
Progressive ratio test 2 inactive lever presses	1.2	1.3	1.4	1.2	-1.2	1.1
Incentive Sensitization - Responses	0.2	0.2	0.3	-0.5	0.4	-0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.4	0.3	-0.4
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.5	0.6	-0.7	0.7
Progressive ratio	1.0	1.1	1.3	1.0	-1.0	1.2
Food seeking constrained by brief footshock	1.5	1.9	2.3	1.5	-1.1	1.5
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.3	0.5	-0.3
Retroperitoneal fat weight	1.1	3.5	4.1	1.9	-1.7	2.0
Reaction time number correct	1.1	1.6	1.8	-1.3	1.2	-1.3
Reaction time mean minus median	6.1	8.1	9.4	2.8	-3.1	2.6
Reaction time mean minus median AUC	4.4	5.7	6.7	2.4	-2.6	2.2
Reaction time num false alarms	1.4	1.8	1.9	1.4	-1.4	1.3
Reaction time num false alarms AUC	1.6	2.2	2.3	1.5	-1.5	1.4
Reaction time trials correct on left	1.1	1.6	1.8	-1.3	1.2	-1.3
Reaction time trials on left	0.9	1.3	1.4	-1.2	1.1	-1.1
Reaction time mean	0.6	0.8	1.0	1.0	-1.0	0.8
Reaction time mean AUC	0.3	0.4	0.6	0.7	-0.6	0.5
Median of all reaction times	0.0	0.0	0.0	0.1	-0.0	-0.1
Reaction time omissions	7.5	10.2	11.2	3.3	-3.1	3.2
Reaction time false alarm rate	1.8	2.5	2.6	1.6	-1.6	1.5
Reaction time premature initiation rate	4.1	5.4	6.4	2.5	-2.0	2.4
Reaction time premature initiations	1.6	2.2	2.7	1.7	-1.2	1.6
Std. dev. reaction times	5.1	7.1	8.0	2.7	-2.8	2.5
Reaction time trials completed	0.9	1.3	1.4	-1.2	1.1	-1.1
Reaction time trials AUC	1.5	2.1	2.4	-1.5	1.4	-1.4
Run reversals in cocaine runway, females	0.4	0.4	0.5	-0.6	0.6	-0.7
Run reversals in cocaine runway, males	1.5	1.4	1.7	0.9	-1.3	1.3
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.0	0.3	-0.1
Latency to leave start box in cocaine runway, F	1.2	1.4	1.8	1.3	-0.8	1.3
Latency to leave start box in cocaine runway, M	2.1	2.0	2.4	-1.5	1.2	-1.5
Std. dev. time between licks in bursts	1.2	1.5	1.6	1.3	-1.1	1.2
Total sessions with >9 infusions	1.3	1.5	1.7	1.3	-1.3	1.1
Short access day 1 total inactive lever presses	1.3	1.4	1.5	1.2	-1.2	1.2
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.2	0.1	-0.2
Short access day 1 total infusions	0.5	0.5	0.6	0.8	-0.7	0.7
Short access day 10 total infusions	2.7	3.0	3.2	1.7	-1.7	1.8
Short access total infusions	1.6	1.8	2.0	1.4	-1.3	1.3
Short access day 1 locomotion	0.2	0.2	0.3	0.5	-0.6	0.4
Short access day 10 total locomotion	0.2	0.2	0.2	0.4	-0.4	0.4
Short access total locomotion	0.5	0.6	0.6	0.7	-0.7	0.8
One hour access (0.3 mA shock)	0.0	0.1	0.1	-0.1	0.2	-0.3
Compulsive drug intake	2.0	2.0	2.5	-1.4	1.3	-1.6
One hour access (shock baseline)	0.0	0.0	0.0	0.1	0.0	-0.0
Social response proportion	0.1	0.1	0.2	0.3	-0.1	0.5
Social responses	5.6	7.2	7.7	2.6	-2.6	2.8
Social time	0.3	0.4	0.8	-0.6	0.9	-0.5
Soleus weight	1.1	3.1	3.3	-1.7	1.8	-1.8
Bone: stiffness	18.6	29.4	30.0	-5.5	5.5	-5.3
Tibialis anterior weight	3.0	10.1	10.5	-3.1	3.2	-3.2
Time to tail flick, vehicle, before self-admin	0.8	0.8	0.9	0.9	-1.0	0.9
Time to tail flick, vehicle, after self-admin	0.6	0.6	0.8	-0.8	0.9	-0.7
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.3	-0.2	0.3
Time to tail flick, test, after self-admin	0.9	0.9	1.2	-0.9	1.1	-0.9
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.0	-0.9	1.0	-0.8
Delta time to tail flick, test, before/after SA	0.6	0.6	0.8	-0.9	0.6	-0.7
Tibia length	4.4	12.3	12.9	-3.6	3.5	-3.4
Ambulatory time before self-admin	3.9	4.1	4.6	2.2	-1.9	2.0
Ambulatory time after self-admin	1.9	2.1	2.4	1.4	-1.6	1.3
Bone: tissue strength	2.4	2.3	2.5	-1.4	1.6	-1.5
Total heroin consumption	1.4	1.6	2.0	-1.2	1.4	-1.2
Bone: trabecular number	4.0	6.2	6.6	-2.6	2.5	-2.4
Bone: trabecular spacing	1.5	1.9	2.7	1.3	-1.6	1.2
Bone: trabecular thickness	0.6	0.7	0.9	-0.7	1.0	-0.9
Bone: trabecular tissue density	0.7	1.0	1.3	-1.0	0.8	-1.2
Water consumed over 24 hours	0.1	0.1	0.1	0.3	-0.3	0.3
Number of responses in last shaping day	0.4	0.4	0.6	-0.6	0.5	-0.8