Cerk

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr7_117235510_117237333	0.03	0.02	1.1e-03	0.01	0.02	0	0.01	3.7e-02	6.2e-03	1.2e-01	2.7e-02
2	Liver	intron excision ratio	chr7_117232430_117235358	0.03	0.02	7.3e-04	0	0.01	0	0.01	1.1e-01	9.1e-03	1.0e-01	6.4e-02
3	LHb	gene expression	Cerk	0.18	0.12	1.0e-03	0.14	0	0.12	0.05	4.1e-04	3.0e-01	1.1e-03	3.0e-02
4	Adipose	gene expression	Cerk	0.2	0.09	0.0e+00	0.18	0.18	0.18	0.18	1.6e-19	9.8e-20	5.4e-20	9.4e-20
5	Brain	mRNA stability	Cerk	0.04	0.04	1.3e-03	0.01	0.03	0.02	0.02	2.1e-02	3.8e-04	1.2e-02	4.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.7	1.1	1.4	1.1	-1.1	0.9	1.1	-1.2
Area under the delay curve	5.3	5.7	7.0	2.4	-2.4	2.6	2.4	-2.0
BMI with tail	3.1	9.9	12.6	-3.1	3.3	-3.6	-3.1	2.6
BMI without tail	1.8	3.7	5.2	-2.0	1.9	-1.4	-1.9	2.3
Body weight	3.1	13.2	14.0	-3.7	3.7	-3.5	-3.5	3.7
Weight adjusted by age	1.4	1.6	2.0	-1.3	1.4	-1.0	-1.4	1.1
Bone surface	0.2	0.4	0.5	0.7	-0.7	0.6	0.6	-0.7
Bone volume	0.4	0.7	0.8	0.9	-0.9	0.9	0.8	-0.8
Breakpoint value in progressive ratio session	0.2	0.3	0.7	0.5	-0.4	-0.1	0.4	-0.8
Number of licking bursts	0.1	0.2	0.4	0.3	-0.4	0.6	0.4	0.1
Context. condit. distance diff. score	1.1	1.3	1.7	-1.1	1.1	-1.2	-1.3	0.9
Locomotion velocity, session 1	1.6	1.7	2.5	-1.4	1.3	-0.8	-1.4	1.6
Locomotion distance, session 1	0.2	0.3	0.7	0.4	-0.5	0.9	0.4	-0.1
Locomotion velocity, session 2	4.5	5.2	7.1	-2.4	2.3	-1.9	-2.2	2.7
Locomotion distance, session 2	0.2	0.3	0.4	0.6	-0.5	0.4	0.5	-0.6
Locomotion velocity, session 3	2.7	3.2	5.9	-1.8	1.6	-1.0	-1.7	2.4
Locomotion distance, session 3	0.2	0.2	0.8	-0.4	0.2	0.2	-0.2	0.9
Stereotopy head waving bouts, day 3	0.4	0.5	0.7	-0.7	0.7	-0.4	-0.8	0.8
Stereotopy head waving duration, day 3	1.1	1.4	2.0	-1.2	1.2	-0.8	-1.4	1.2
Locomotion velocity, session 7	1.4	1.5	2.9	-1.3	1.1	-0.7	-1.1	1.7
Locomotion distance, session 7	0.4	0.5	0.9	-0.7	0.7	-0.6	-0.6	1.0
Stereotopy head waving bouts, day 7	1.1	1.2	1.6	-1.1	1.1	-0.8	-1.2	1.3
Stereotopy head waving duration, day 7	0.4	0.5	0.7	-0.7	0.6	-0.4	-0.7	0.8
Locomotion velocity, session 8	5.4	6.4	7.0	-2.6	2.6	-2.6	-2.6	2.2
Locomotion distance, session 8	0.6	0.9	1.1	-1.0	0.9	-0.9	-1.0	0.9
Degree of sensitization distance	1.0	1.0	1.9	-0.9	1.0	-1.4	-0.9	0.4
Degree of sensitization stereotypy	0.6	0.6	0.7	-0.8	0.8	-0.7	-0.8	0.9
Conditioned locomotion	0.1	0.1	0.1	-0.3	0.2	-0.2	-0.3	0.3
Cocaine response after cond. corrected	0.6	0.7	0.9	-0.9	0.8	-0.6	-0.8	1.0
Cocaine response after cond. not corrected	0.4	0.5	1.1	-0.7	0.6	-0.3	-0.7	1.0
Cocaine response before conditioning	0.2	0.3	0.5	0.5	-0.6	0.7	0.5	-0.2
Saline control response	0.3	0.4	0.7	-0.6	0.7	-0.9	-0.6	0.3
Bone: connectivity density	0.3	0.5	0.6	0.7	-0.7	0.7	0.8	-0.6
Bone: cortical apparent density	1.5	2.0	2.2	1.4	-1.4	1.2	1.5	-1.5
Bone: cortical area	1.3	2.0	2.8	-1.4	1.5	-1.7	-1.4	0.9
Bone: cortical porosity	1.7	1.9	3.4	-1.4	1.4	-1.8	-1.3	0.8
Bone: cortical porosity	1.5	1.6	2.9	-1.2	1.3	-1.7	-1.2	0.7
Bone: cortical thickness	0.1	0.1	0.3	0.1	-0.0	-0.3	0.1	-0.6
Bone: cortical thickness	1.2	1.4	2.8	-1.1	1.3	-1.7	-1.2	0.4
Bone: cortical tissue density	1.2	1.5	1.7	1.3	-1.2	1.1	1.3	-1.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.4	-0.4	0.4	0.6	-0.4
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.8	1.1	-1.1	1.2	1.3	-1.1
Condit. Reinf. active responses	0.4	0.5	0.8	0.6	-0.7	0.9	0.8	-0.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.1	-0.1	0.3	0.0	0.5
Incentive salience index mean	0.3	0.3	0.6	-0.6	0.6	-0.2	-0.3	0.8
Condit. Reinf. lever presses	1.8	2.4	3.9	-1.7	1.5	-1.0	-1.5	2.0
Condit. Reinf. active minus inactive responses	0.3	0.4	0.8	-0.7	0.7	-0.9	-0.4	0.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.2	0.2	-0.3	-0.0	0.0
Condit. Reinf. active responses	1.4	1.9	2.8	-1.4	1.5	-1.7	-1.2	1.0
Condit. Reinf. inactive responses	2.8	3.4	4.2	-1.8	1.9	-2.1	-1.8	1.6
Condit. Reinf. lever presses	0.4	0.6	0.7	-0.8	0.8	-0.7	-0.7	0.8
Condit. Reinf. lever reinforcers received	0.9	1.2	2.0	-1.1	1.2	-1.4	-1.0	0.8
Conditioned reinforcement - actives	0.2	0.2	0.5	-0.5	0.3	-0.2	-0.3	0.7
Conditioned reinforcement - inactives	1.0	1.1	1.5	-1.0	1.0	-1.2	-1.1	0.8
Conditioned locomotion	3.0	3.6	3.9	-1.9	1.9	-1.8	-2.0	2.0
Patch foraging indifference point 0 sec	0.0	0.0	0.0	-0.0	0.0	-0.1	0.0	0.0
Patch foraging indifference point AUC	0.2	0.3	0.4	0.5	-0.5	0.7	0.5	-0.3
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.1	0.1	0.1	-0.0	0.2
Delay disc. indifference point, 16s delay	5.9	6.0	6.4	2.5	-2.5	2.5	2.5	-2.3
Delay disc. indifference point, 2s delay	0.9	1.0	1.2	1.0	-1.0	1.1	1.1	-0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.3	-0.2	0.2	0.2	-0.4
Delay disc. indifference point, 4s delay	7.6	8.0	10.5	2.8	-2.9	3.2	2.8	-2.3
Delay disc. indifference point, 8s delay	5.1	5.3	6.1	2.3	-2.3	2.5	2.3	-2.0
Indifference point function ln k	3.6	5.0	5.2	-2.3	2.3	-2.2	-2.3	2.1
Indifference point function log k	3.6	5.0	5.2	-2.3	2.3	-2.2	-2.3	2.1
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	0.3	-0.3	0.3	0.3	-0.2
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	0.1	-0.0	0.2	0.1	-0.0
Patch foraging total patch changes 18 sec	0.4	0.5	0.6	0.7	-0.8	0.8	0.8	-0.5
Patch foraging total patch changes 24 sec	0.0	0.0	0.0	0.2	-0.2	0.2	0.1	0.1
Patch foraging total patch changes 6 sec	0.5	0.8	0.9	0.9	-0.9	0.9	0.9	-0.7
Patch foraging time to switch 0 sec	0.4	0.7	0.9	0.9	-0.8	0.7	0.8	-1.0
Patch foraging water rate 0 sec	0.4	0.6	0.7	-0.8	0.8	-0.7	-0.7	0.7
Patch foraging water rate 12 sec	0.9	1.4	1.8	-1.2	1.1	-1.1	-1.2	1.4
Patch foraging water rate 18 sec	0.2	0.2	0.3	-0.5	0.5	-0.3	-0.5	0.5
Patch foraging water rate 24 sec	0.6	0.8	1.1	-0.9	1.0	-1.1	-0.9	0.6
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.3	0.1	0.1	-0.2	0.5
Seeking ratio, delayed vs. immediate footshock	1.5	1.7	2.2	1.3	-1.3	1.1	1.5	-1.3
Distance traveled before self-admin	0.3	0.4	0.7	-0.6	0.5	-0.4	-0.5	0.9
Distance traveled after self-admin	0.9	1.0	1.1	-1.0	1.1	-1.1	-1.0	0.8
Extensor digitorum longus weight	0.5	2.0	2.1	-1.4	1.4	-1.4	-1.5	1.4
Bone: elastic displacement	0.8	0.9	1.2	-1.0	0.9	-0.7	-0.9	1.1
Bone: elastic work	3.5	4.5	5.5	-2.1	2.2	-2.3	-2.2	1.7
Bone: endosteal estimation	2.2	4.8	5.3	-2.2	2.2	-2.0	-2.3	2.1
Bone: endosteal perimeter	3.7	7.6	8.0	-2.8	2.8	-2.7	-2.8	2.7
Epididymis fat weight	0.6	1.3	1.4	-1.2	1.2	-1.2	-1.1	1.1
Delta time in closed arm before/after self-admin	0.1	0.0	0.2	0.2	-0.1	-0.2	0.2	-0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.4	-0.2	0.0	0.4	-0.2	0.7
Diff in mean of infusions in LGA sessions	0.2	0.2	0.9	-0.2	0.3	-1.0	-0.2	-0.4
Delay discount exponential model param	5.4	5.7	7.1	-2.4	2.4	-2.7	-2.4	2.0
Extinction: sum of active levers before priming	0.2	0.2	0.6	0.5	-0.4	-0.1	0.4	-0.8
Active lever presses in extinction session 6	0.6	0.6	1.2	-0.7	0.8	-1.1	-0.7	0.4
Bone: final force	0.5	0.8	1.9	-0.7	0.9	-1.4	-0.9	-0.0
Bone: final moment	0.6	1.0	2.2	-0.8	1.0	-1.5	-1.0	0.0
Food consumed during 24 hour testing period	4.6	5.6	6.4	-2.5	2.5	-2.4	-2.4	2.0
Glucose	0.1	0.1	0.3	0.2	-0.1	-0.2	0.3	-0.6
Heart weight	0.5	0.7	1.1	0.9	-0.8	0.7	0.8	-1.0
Delay discount hyperbolic model param	5.0	5.3	6.8	-2.3	2.3	-2.6	-2.3	1.9
Intermittent access intake day 1-15 change	0.4	0.4	0.8	-0.6	0.7	-0.9	-0.5	0.1
Intermittent access intake escalation	1.1	1.1	1.7	-1.0	1.1	-1.3	-1.0	0.6
Intermittent access intake escalation 2	0.2	0.2	0.4	-0.1	0.2	-0.6	-0.1	-0.6
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.3	-0.1	0.2	-0.5	-0.0	-0.4
Intermitt. access day 15 inactive lever presses	2.5	2.7	4.6	-1.6	1.7	-2.1	-1.6	1.0
Intermitt. access escalation Index	0.5	0.4	0.6	-0.6	0.7	-0.7	-0.7	0.6
Intermittent access day 1 total infusions	4.1	4.8	5.5	-2.3	2.2	-2.0	-2.1	2.4
Intermittent access day 15 total infusions	4.7	5.2	5.9	-2.4	2.3	-2.4	-2.2	2.1
Intermittent access terminal intake (last 3 days)	7.0	7.7	8.9	-2.8	2.8	-3.0	-2.7	2.4
Intermittent access total infusions	6.2	6.9	7.4	-2.7	2.7	-2.7	-2.6	2.4
Intermittent access day 1 locomotion	2.3	2.4	3.4	-1.6	1.5	-1.4	-1.5	1.8
Intermittent access day 15 total locomotion	4.6	5.0	5.4	-2.3	2.2	-2.2	-2.2	2.3
Intermittent access total locomotion	4.2	4.8	5.4	-2.2	2.2	-2.3	-2.2	2.0
Intermittent access standard deviation	0.8	0.9	2.1	-0.9	1.0	-1.5	-0.8	0.3
Left kidney weight	12.6	35.4	37.7	-6.0	6.1	-5.9	-6.1	5.6
Right kidney weight	11.6	32.4	35.5	-5.8	6.0	-5.9	-5.8	5.0
Cocaine induced anxiety	1.1	1.3	2.7	-1.0	1.2	-1.6	-1.1	0.5
Post-drug Anxiety	0.5	0.5	1.8	-0.3	0.6	-1.4	-0.4	-0.5
Baseline Anxiety	0.9	1.0	1.2	1.0	-1.0	0.8	0.9	-1.1
Tail length	0.1	0.4	1.3	0.0	-0.3	1.1	0.2	0.9
Length with tail	0.7	2.4	3.9	-1.7	1.5	-1.1	-1.3	2.0
Length without tail	1.6	3.6	6.4	-1.9	2.0	-2.5	-1.7	1.2
Times rat made contact with spout	0.6	0.7	1.3	-0.9	0.8	-0.6	-0.8	1.2
Lifetime Intake	6.2	7.1	7.6	-2.7	2.7	-2.6	-2.6	2.6
Liver weight, left	0.3	0.4	0.7	-0.6	0.7	-0.9	-0.6	0.4
Liver weight, right	1.4	2.4	4.2	-1.6	1.4	-1.1	-1.4	2.1
Locomotor activity	4.3	6.7	8.2	-2.7	2.6	-2.2	-2.6	2.9
Locomotor testing distance	0.8	1.3	1.8	-1.1	1.1	-0.9	-1.2	1.3
Locomotor testing rearing	1.1	1.8	2.4	-1.3	1.3	-1.0	-1.4	1.5
Locomotion in novel chamber	0.4	0.5	1.6	0.2	-0.4	1.3	0.1	0.8
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	0.2	-0.2	0.2	0.1	-0.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.3	0.3	-0.5	-0.2	0.5
Change in fecal boli incidents, locomotor task	0.3	0.3	0.8	0.5	-0.6	0.9	0.4	-0.2
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	-0.0	0.1	0.1	-0.2	0.1
Bouts of movement, locomotor time 1	0.6	0.7	1.1	-0.8	0.8	-1.0	-0.8	0.5
Total resting periods, locomotor time 1	0.2	0.2	0.5	-0.3	0.4	-0.7	-0.4	-0.1
Rest time, locomotor task time 1	0.5	0.5	0.6	-0.7	0.7	-0.8	-0.8	0.8
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.2	0.2	0.0	-0.2	0.3
Vertical activity count, locomotor time 1	0.1	0.2	0.3	0.3	-0.3	0.5	0.3	-0.4
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.5	-0.4	0.5	-0.7	-0.5	0.1
Bouts of movement, locomotor time 2	1.3	1.4	2.0	1.3	-1.2	0.8	1.1	-1.4
Total resting periods, locomotor time 2	1.3	1.4	2.1	1.3	-1.2	0.8	1.2	-1.4
Rest time, locomotor task time 2	1.4	1.6	2.9	1.2	-1.4	1.7	1.3	-0.4
Distance moved, locomotor task time 2	3.1	3.6	4.2	-1.9	2.0	-2.0	-2.0	1.5
Vertical activity count, locomotor time 2	2.9	3.2	4.0	-1.8	2.0	-1.9	-1.8	1.3
Light reinforcement 1	0.8	1.5	3.2	-1.2	1.1	-0.4	-1.2	1.8
Light reinforcement 2	4.6	6.1	6.5	-2.5	2.5	-2.3	-2.5	2.5
Bone: marrow area	2.2	4.7	5.2	-2.2	2.2	-2.1	-2.3	2.1
Bone: maximum diameter	6.3	11.5	12.7	-3.4	3.5	-3.6	-3.5	2.9
Bone: maximum force	0.6	1.0	2.3	-0.8	1.0	-1.5	-1.0	0.0
Bone: maximum moment	0.7	1.2	2.7	-0.9	1.1	-1.6	-1.2	0.1
Mean time between licks in bursts	0.9	1.3	2.2	1.1	-1.2	1.5	1.0	-0.7
Mean num. licks in bursts	1.1	1.4	2.1	-1.1	1.2	-1.4	-1.2	0.7
Cd content in liver	0.2	0.2	0.4	0.5	-0.4	0.3	0.4	-0.7
Co content in liver	0.9	1.1	1.4	-1.1	1.1	-0.7	-1.0	1.2
Cu content in liver	7.8	9.5	10.3	3.2	-3.2	3.1	3.1	-2.8
Fe content in liver	0.3	0.3	0.7	-0.6	0.6	-0.8	-0.5	0.3
K content in liver	0.1	0.1	0.2	0.1	-0.0	-0.4	0.1	-0.5
Mg content in liver	0.1	0.1	0.4	0.2	-0.1	-0.4	0.1	-0.7
Mn content in liver	1.9	2.2	2.9	-1.5	1.4	-1.2	-1.5	1.7
Na content in liver	3.4	3.5	4.2	1.9	-1.9	1.5	2.1	-2.0
Rb content in liver	0.8	1.1	1.7	1.1	-1.0	0.8	0.9	-1.3
Se content in liver	0.1	0.1	0.2	-0.2	0.2	-0.1	-0.4	0.4
Sr content in liver	1.3	1.2	3.7	0.9	-1.1	1.9	0.6	-0.1
Zn content in liver	0.7	0.8	1.1	0.9	-0.9	1.0	0.8	-0.6
Bone: minimum diameter	2.2	4.1	4.4	-2.1	2.1	-1.9	-2.0	2.0
Time in familiar zone, hab. session 1	1.4	1.3	1.4	-1.1	1.1	-1.1	-1.2	1.0
Time in novel zone, hab. session 1	0.3	0.3	0.4	0.5	-0.5	0.5	0.5	-0.7
Total zone transitions, hab. session 1	2.3	3.3	3.5	1.9	-1.9	1.8	1.8	-1.8
Total locomotion distance, hab. session 1	0.0	0.0	0.2	0.1	-0.2	0.4	0.0	0.2
Locomotion velocity, hab. session 1	0.0	0.1	0.1	0.0	-0.1	0.4	-0.0	0.3
Time in familiar zone, hab. session 2	0.4	0.4	0.8	-0.6	0.6	-0.3	-0.6	0.9
Time in novel zone, hab. session 2	1.1	1.1	1.7	1.0	-1.0	0.8	1.0	-1.3
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.1	0.2	-0.4	-0.2	-0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.1	-0.3	0.3	-0.4	-0.3	0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.3	0.2
Novel to familiar place preference ratio	0.7	0.7	1.2	0.8	-0.9	1.1	0.7	-0.8
Novelty place preference	0.3	0.3	0.7	0.5	-0.5	0.9	0.4	-0.4
Time in novel zone, NPP test	0.5	0.5	1.0	0.6	-0.6	1.0	0.5	-0.5
Total zone transitions, NPP test	1.0	1.4	1.6	1.3	-1.3	1.0	1.1	-1.2
Total locomotion distance, NPP test	0.1	0.1	0.2	0.4	-0.4	0.3	0.3	-0.3
Locomotion velocity, NPP test	0.1	0.1	0.1	0.3	-0.4	0.3	0.3	-0.1
Intraocular pressure	1.2	1.7	3.1	-1.4	1.2	-0.9	-1.1	1.7
Delta distance traveled before/after self-admin	0.4	0.4	0.5	-0.7	0.7	-0.5	-0.6	0.6
Delta ambulatory time before/after self-admin	0.2	0.3	0.3	-0.6	0.6	-0.5	-0.5	0.4
Parametrial fat weight	0.2	0.5	1.4	0.3	-0.5	1.2	0.6	0.4
Pavlov. Cond. lever latency	1.1	1.4	1.8	1.3	-1.2	0.9	1.2	-1.4
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.1	-0.1	0.0	0.2	-0.3
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	-0.5	0.5	-0.6	-0.3	0.2
Pavlov. Cond. index score	0.3	0.4	0.5	-0.6	0.6	-0.7	-0.5	0.5
Pavlov. Cond. latency score	0.5	0.6	0.7	-0.8	0.8	-0.8	-0.8	0.7
Pavlov. Cond. lever contacts	2.2	2.6	3.4	-1.7	1.6	-1.3	-1.6	1.8
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	-0.2	0.3	0.0	0.0
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.0	0.9	-0.9	0.8	1.0	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.4	0.4
Pavlov. Cond. response bias	0.8	1.0	1.2	-1.1	1.0	-1.0	-0.9	1.1
Pavlov. Cond. lever latency	0.1	0.2	0.2	0.4	-0.5	0.5	0.3	-0.3
Pavlov. Cond. magazine entry latency	2.1	2.4	4.3	1.6	-1.4	0.9	1.6	-2.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.8	0.3	-0.2	-0.2	0.5	-0.9
Pavlov. Cond. index score	0.3	0.4	0.9	0.6	-0.5	0.2	0.6	-0.9
Pavlov. Cond. latency score	0.2	0.3	0.8	0.5	-0.4	0.1	0.6	-0.9
Pavlov. Cond. lever contacts	0.2	0.2	0.5	-0.4	0.5	-0.7	-0.3	0.1
Pavlov. Cond. magazine entry number	0.9	1.2	2.0	-1.1	1.0	-0.6	-1.1	1.4
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.7	-0.8	0.9	-1.3	-0.9	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	0.6	-0.5	0.3	0.7	-0.9
Pavlov. Cond. response bias	0.1	0.1	0.3	0.2	-0.1	-0.2	0.3	-0.6
Time in closed arm before self-admin	0.4	0.5	1.2	0.6	-0.5	0.1	0.6	-1.1
Time in closed arm after self-admin	0.0	0.0	0.1	-0.1	0.1	-0.3	-0.1	-0.2
Time in open arm before self-admin	0.2	0.3	0.8	0.3	-0.5	0.9	0.3	0.3
Time in open arm after self-admin	0.3	0.4	0.9	0.5	-0.6	1.0	0.6	0.1
Bone: periosteal estimation	2.4	5.0	5.5	-2.3	2.3	-2.3	-2.3	1.9
Bone: periosteal perimeter	5.0	8.3	8.9	-3.0	3.0	-2.7	-2.9	2.8
Bone: post-yield work	1.1	1.6	2.2	1.3	-1.2	1.0	1.2	-1.5
Progressive ratio test 1 active lever presses	2.9	3.0	4.9	-1.8	1.6	-1.2	-1.7	2.2
Progressive ratio test 1 breakpoint	2.7	2.8	4.7	-1.7	1.5	-1.2	-1.6	2.2
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.4	-0.9	0.8	-0.7	-0.9	1.2
Progressive ratio test 2 active lever presses	0.7	0.7	1.3	-0.8	0.9	-1.1	-0.6	0.6
Progressive ratio test 2 breakpoint	0.5	0.6	1.1	-0.8	0.8	-1.1	-0.6	0.6
Progressive ratio test 2 inactive lever presses	1.9	2.1	3.4	-1.5	1.5	-1.8	-1.3	1.1
Incentive Sensitization - Responses	0.3	0.3	1.0	-0.4	0.5	-1.0	-0.3	-0.1
Incentive Sensitization - Breakpoint	0.3	0.3	1.1	-0.5	0.6	-1.0	-0.3	0.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	0.2	-0.1	-0.2	0.2	-0.6
Progressive ratio	0.3	0.4	0.5	0.6	-0.7	0.7	0.7	-0.4
Food seeking constrained by brief footshock	0.7	0.9	1.6	-0.9	1.0	-1.3	-0.8	0.7
Seeking ratio, punishment vs. effort	0.6	0.8	1.7	-0.8	0.9	-1.3	-0.8	0.3
Retroperitoneal fat weight	3.2	10.6	11.2	-3.3	3.3	-3.1	-3.2	3.3
Reaction time number correct	0.2	0.3	0.4	0.5	-0.6	0.6	0.6	-0.3
Reaction time mean minus median	0.2	0.2	0.3	0.5	-0.5	0.5	0.5	-0.3
Reaction time mean minus median AUC	0.1	0.1	0.2	0.2	-0.3	0.4	0.2	0.2
Reaction time num false alarms	0.2	0.2	0.6	-0.5	0.4	-0.0	-0.4	0.8
Reaction time num false alarms AUC	0.3	0.4	0.9	-0.6	0.5	-0.0	-0.6	0.9
Reaction time trials correct on left	0.2	0.3	0.4	0.5	-0.6	0.6	0.6	-0.3
Reaction time trials on left	0.2	0.3	0.5	0.5	-0.6	0.7	0.6	-0.3
Reaction time mean	2.7	3.7	4.9	2.0	-1.9	1.5	1.9	-2.2
Reaction time mean AUC	3.1	4.2	5.0	2.1	-2.1	1.7	2.0	-2.2
Median of all reaction times	3.5	4.8	6.7	2.3	-2.2	1.7	2.1	-2.6
Reaction time omissions	1.7	2.3	2.4	1.5	-1.5	1.4	1.5	-1.5
Reaction time false alarm rate	0.5	0.7	1.0	-0.9	0.8	-0.5	-0.8	1.0
Reaction time premature initiation rate	0.1	0.2	0.5	-0.0	0.2	-0.7	-0.1	-0.7
Reaction time premature initiations	0.2	0.2	0.8	0.4	-0.2	-0.1	0.4	-0.9
Std. dev. reaction times	0.8	1.2	1.3	1.1	-1.1	1.0	1.1	-1.1
Reaction time trials completed	0.2	0.3	0.5	0.5	-0.6	0.7	0.6	-0.3
Reaction time trials AUC	0.1	0.1	0.2	0.3	-0.3	0.4	0.4	-0.1
Run reversals in cocaine runway, females	0.2	0.2	0.9	0.2	-0.3	0.9	0.2	0.2
Run reversals in cocaine runway, males	0.8	0.7	1.7	-0.8	0.7	-0.1	-0.9	1.3
Latency to leave start box in cocaine runway	2.2	2.4	2.8	-1.6	1.6	-1.4	-1.7	1.5
Latency to leave start box in cocaine runway, F	1.1	1.2	1.4	-1.1	1.1	-1.0	-1.2	1.0
Latency to leave start box in cocaine runway, M	2.0	1.9	2.2	-1.4	1.5	-1.3	-1.4	1.2
Std. dev. time between licks in bursts	0.2	0.3	0.6	0.6	-0.5	0.3	0.4	-0.8
Total sessions with >9 infusions	4.7	5.2	6.1	-2.4	2.3	-1.8	-2.4	2.5
Short access day 1 total inactive lever presses	4.0	4.5	4.7	-2.2	2.2	-2.1	-2.2	2.1
Short access day 10 total inactive lever presses	0.3	0.4	0.9	-0.5	0.6	-0.9	-0.5	0.2
Short access day 1 total infusions	2.9	3.1	4.2	-1.9	1.8	-1.3	-1.7	2.0
Short access day 10 total infusions	6.1	6.8	7.3	-2.7	2.6	-2.4	-2.6	2.7
Short access total infusions	7.2	8.1	8.7	-3.0	2.9	-2.7	-2.8	2.9
Short access day 1 locomotion	0.2	0.2	0.2	-0.5	0.5	-0.4	-0.5	0.4
Short access day 10 total locomotion	0.8	0.9	2.2	-0.9	0.7	-0.3	-1.0	1.5
Short access total locomotion	2.6	2.7	2.9	-1.7	1.7	-1.5	-1.6	1.7
One hour access (0.3 mA shock)	1.3	1.6	1.7	-1.3	1.3	-1.3	-1.1	1.2
Compulsive drug intake	1.6	1.6	2.6	1.3	-1.2	0.9	1.2	-1.6
One hour access (shock baseline)	4.0	4.6	5.2	-2.2	2.1	-2.0	-2.0	2.3
Social response proportion	1.5	1.6	2.2	-1.3	1.3	-1.5	-1.2	1.0
Social responses	2.0	2.6	3.5	-1.6	1.6	-1.3	-1.6	1.9
Social time	0.0	0.1	0.1	-0.0	-0.1	0.4	0.0	0.4
Soleus weight	0.2	0.6	1.2	-0.7	0.8	-1.1	-0.8	0.4
Bone: stiffness	0.8	1.3	3.8	1.1	-0.8	0.1	0.9	-1.9
Tibialis anterior weight	0.2	0.6	0.8	0.8	-0.8	0.7	0.7	-0.9
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.2	-0.3	0.5	0.3	0.1
Time to tail flick, vehicle, after self-admin	0.4	0.5	0.5	-0.7	0.7	-0.7	-0.7	0.6
Time to tail flick, test, before self-admin	2.4	2.3	2.9	-1.6	1.5	-1.2	-1.5	1.7
Time to tail flick, test, after self-admin	0.1	0.1	0.5	0.2	-0.1	-0.3	0.0	-0.7
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.8	-0.5	0.6	-0.9	-0.5	0.1
Delta time to tail flick, test, before/after SA	2.8	2.5	4.3	1.6	-1.5	1.1	1.5	-2.1
Tibia length	0.2	0.7	0.9	-0.8	0.9	-0.9	-0.7	0.6
Ambulatory time before self-admin	0.2	0.2	0.5	-0.4	0.3	-0.1	-0.3	0.7
Ambulatory time after self-admin	0.1	0.1	0.2	-0.3	0.4	-0.4	-0.3	0.1
Bone: tissue strength	0.7	0.6	1.4	0.8	-0.7	0.3	0.7	-1.2
Total heroin consumption	0.1	0.1	0.6	-0.2	0.3	-0.7	-0.2	-0.2
Bone: trabecular number	0.4	0.7	0.9	0.8	-0.9	0.9	0.9	-0.6
Bone: trabecular spacing	2.5	3.3	3.6	-1.9	1.9	-1.6	-1.8	1.8
Bone: trabecular thickness	0.1	0.1	0.1	0.3	-0.3	0.3	0.3	-0.3
Bone: trabecular tissue density	1.9	2.6	3.6	1.7	-1.6	1.2	1.6	-1.9
Water consumed over 24 hours	2.1	2.5	2.8	-1.6	1.7	-1.6	-1.6	1.3
Number of responses in last shaping day	0.0	0.0	0.0	-0.1	0.1	0.1	-0.0	0.2