Hub : Genes

Celsr3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr8_109542778_109543072 0.03 0.02 3.6e-03 0.01 0.01 0.02 0.01 1.6e-02 1.3e-02 6.0e-03 9.2e-03
2 Brain intron excision ratio chr8_109542921_109543072 0.06 0.08 6.1e-03 0.03 0.02 0.03 0.03 1.7e-03 9.9e-03 2.0e-03 1.7e-03
3 Brain gene expression Celsr3 0.05 0.03 1.5e-04 0.05 0.04 0.04 0.05 1.8e-05 7.4e-05 5.0e-05 2.5e-05
4 PL intron excision ratio chr8_109542921_109543072 0.02 0.02 5.7e-03 0.02 0.01 0.01 0.01 2.8e-03 5.7e-02 4.9e-02 2.1e-02
5 Brain intron excision ratio chr8_109542778_109543072 0.03 0.03 1.6e-03 0.02 0.02 0.02 0.01 5.3e-03 4.8e-03 6.6e-03 1.4e-02
6 LHb isoform ratio XM_006243860.4 0.23 0.15 9.5e-03 -0.01 -0.01 -0.01 -0.01 7.0e-01 7.8e-01 7.0e-01 6.8e-01
7 Adipose gene expression Celsr3 0.02 0.02 9.8e-03 0 0.01 0.02 0.01 8.1e-02 5.2e-02 5.3e-03 4.4e-02
8 LHb isoform ratio NM_031320.1 0.29 0.18 8.8e-03 0.04 -0.01 -0 0 3.8e-02 5.7e-01 4.1e-01 2.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.30.51.90.10.60.1-0.0-0.80.9-0.71.4
Area under the delay curve0.80.92.1-1.4-0.9-1.51.20.5-0.20.20.8
BMI with tail0.20.61.01.01.00.8-0.8-0.4-0.3-0.2-1.0
BMI without tail1.12.34.02.01.91.7-1.8-1.40.8-1.4-0.0
Body weight3.112.924.95.04.44.5-4.5-3.11.9-2.0-0.9
Weight adjusted by age0.30.41.20.70.30.8-0.40.2-0.30.6-1.1
Bone surface0.10.10.2-0.4-0.1-0.40.50.1-0.20.30.0
Bone volume0.00.10.2-0.20.1-0.20.3-0.20.10.20.4
Breakpoint value in progressive ratio session0.40.40.80.70.50.5-0.6-0.60.7-0.90.7
Number of licking bursts1.01.22.6-0.5-1.0-0.40.41.3-1.41.2-1.6
Context. condit. distance diff. score0.00.10.20.1-0.10.1-0.10.1-0.20.4-0.4
Locomotion velocity, session 10.10.10.2-0.3-0.0-0.30.3-0.10.20.40.3
Locomotion distance, session 10.81.01.81.01.30.9-0.8-1.31.1-0.70.8
Locomotion velocity, session 20.40.51.0-0.7-0.6-0.60.70.6-0.71.0-0.7
Locomotion distance, session 20.10.10.4-0.30.2-0.30.4-0.40.4-0.10.6
Locomotion velocity, session 30.30.40.80.00.7-0.10.0-0.90.9-0.60.9
Locomotion distance, session 30.80.82.0-1.4-0.7-1.41.40.4-0.30.30.3
Stereotopy head waving bouts, day 30.60.82.70.3-0.40.2-0.30.9-1.11.0-1.7
Stereotopy head waving duration, day 30.20.20.40.60.20.6-0.70.1-0.20.1-0.6
Locomotion velocity, session 70.70.82.00.10.60.1-0.1-1.01.2-1.21.4
Locomotion distance, session 70.60.81.8-1.3-0.8-1.31.30.4-0.0-0.00.7
Stereotopy head waving bouts, day 70.00.00.2-0.10.10.0-0.0-0.20.3-0.30.4
Stereotopy head waving duration, day 70.40.50.60.70.70.7-0.7-0.80.7-0.60.5
Locomotion velocity, session 80.20.30.60.30.70.3-0.2-0.80.7-0.40.5
Locomotion distance, session 80.60.81.70.41.00.4-0.3-1.31.3-0.81.2
Degree of sensitization distance1.01.01.51.20.91.2-1.2-0.80.8-1.00.5
Degree of sensitization stereotypy0.50.51.30.20.60.3-0.3-0.91.0-0.81.1
Conditioned locomotion1.41.63.2-1.8-1.6-1.71.61.0-0.60.60.6
Cocaine response after cond. corrected0.70.82.90.7-0.10.7-0.70.6-0.91.0-1.7
Cocaine response after cond. not corrected1.01.12.51.60.91.5-1.5-0.3-0.10.2-1.2
Cocaine response before conditioning1.31.52.41.01.50.9-0.9-1.51.4-1.31.1
Saline control response2.93.85.81.51.81.4-1.5-2.22.4-2.22.3
Bone: connectivity density0.50.83.4-0.50.1-0.40.5-0.71.1-0.91.9
Bone: cortical apparent density0.10.10.3-0.5-0.3-0.50.40.10.1-0.10.6
Bone: cortical area1.42.15.1-0.6-1.1-0.50.61.6-1.92.0-2.3
Bone: cortical porosity0.80.93.5-0.10.3-0.10.1-0.91.3-1.21.9
Bone: cortical porosity0.80.93.7-0.30.1-0.30.3-0.71.2-1.11.9
Bone: cortical thickness1.01.76.50.3-0.50.2-0.21.2-1.71.6-2.5
Bone: cortical thickness0.00.00.1-0.0-0.1-0.1-0.00.3-0.30.2-0.4
Bone: cortical tissue density0.10.20.4-0.5-0.3-0.50.40.00.2-0.10.7
Condit. Reinf. active minus inactive responses0.10.10.40.0-0.10.0-0.00.3-0.30.5-0.6
Condit. Reinf. active-inactive response ratio0.20.31.00.3-0.00.2-0.30.4-0.40.7-1.0
Condit. Reinf. active responses0.10.20.5-0.1-0.4-0.10.10.5-0.50.5-0.7
Condit. Reinf. inactive responses0.20.20.4-0.5-0.6-0.50.50.4-0.50.2-0.2
Incentive salience index mean0.20.20.4-0.3-0.4-0.40.30.5-0.50.7-0.6
Condit. Reinf. lever presses1.01.41.8-1.3-1.3-1.31.31.2-1.11.0-0.6
Condit. Reinf. active minus inactive responses0.81.01.91.41.41.1-1.2-1.00.7-0.4-0.1
Condit. Reinf. active-inactive response ratio0.60.61.31.21.01.0-1.0-0.60.30.0-0.6
Condit. Reinf. active responses0.91.22.11.41.41.2-1.3-1.10.9-0.50.1
Condit. Reinf. inactive responses0.00.00.1-0.20.0-0.10.1-0.10.20.10.3
Condit. Reinf. lever presses1.01.32.61.51.61.3-1.3-1.10.8-0.6-0.2
Condit. Reinf. lever reinforcers received1.01.32.31.51.51.3-1.4-1.20.9-0.60.1
Conditioned reinforcement - actives0.20.20.4-0.4-0.6-0.60.30.3-0.30.0-0.2
Conditioned reinforcement - inactives2.73.05.7-1.2-1.6-1.31.02.0-2.21.7-2.4
Conditioned locomotion0.20.20.7-0.5-0.3-0.50.3-0.20.3-0.50.8
Patch foraging indifference point 0 sec2.13.45.51.61.71.4-1.4-2.12.2-2.31.9
Patch foraging indifference point AUC0.70.81.80.30.70.3-0.4-0.91.1-1.21.3
Delay disc. indifference point, 0s delay0.00.00.1-0.0-0.1-0.1-0.2-0.10.2-0.20.3
Delay disc. indifference point, 16s delay0.40.41.0-1.0-0.6-1.00.80.3-0.10.10.5
Delay disc. indifference point, 2s delay0.10.10.3-0.5-0.2-0.40.50.2-0.00.30.3
Delay disc. indifference point, 24s delay0.50.51.3-1.0-0.6-1.11.00.3-0.10.20.5
Delay disc. indifference point, 4s delay0.80.91.6-1.3-1.1-1.21.10.9-0.60.70.0
Delay disc. indifference point, 8s delay1.01.02.3-1.5-0.9-1.51.40.6-0.20.40.7
Indifference point function ln k0.50.71.1-0.9-0.6-1.01.00.6-0.90.9-0.6
Indifference point function log k0.50.71.1-0.9-0.6-1.01.00.6-0.90.9-0.6
Patch foraging total patch changes 0 sec1.93.04.71.71.71.4-1.5-1.91.9-2.21.5
Patch foraging total patch changes 12 sec1.21.52.51.31.21.2-1.2-1.31.3-1.60.9
Patch foraging total patch changes 18 sec3.24.26.91.82.01.7-1.7-2.12.3-2.61.9
Patch foraging total patch changes 24 sec2.02.43.61.91.81.6-1.7-1.61.4-1.60.5
Patch foraging total patch changes 6 sec1.42.04.10.71.00.5-0.6-1.51.8-2.02.0
Patch foraging time to switch 0 sec0.50.71.6-0.4-0.8-0.20.41.0-1.11.0-1.3
Patch foraging water rate 0 sec0.10.20.30.50.40.4-0.5-0.40.4-0.50.2
Patch foraging water rate 12 sec0.10.10.20.40.30.4-0.4-0.30.2-0.2-0.1
Patch foraging water rate 18 sec0.50.72.20.2-0.3-0.1-0.10.6-1.01.5-1.3
Patch foraging water rate 24 sec0.40.51.11.10.81.0-1.0-0.50.3-0.3-0.2
Patch foraging water rate 6 sec0.20.30.40.50.70.5-0.6-0.60.4-0.50.4
Seeking ratio, delayed vs. immediate footshock1.01.22.2-1.4-1.4-1.41.50.7-0.40.40.6
Distance traveled before self-admin0.91.02.5-0.9-0.6-0.40.90.8-1.01.6-1.2
Distance traveled after self-admin0.91.01.9-1.3-0.6-0.71.40.8-0.81.4-0.7
Extensor digitorum longus weight0.31.21.6-0.8-1.1-0.80.81.2-1.21.3-1.3
Bone: elastic displacement0.20.31.00.1-0.10.0-0.10.5-0.60.6-1.0
Bone: elastic work0.30.41.40.60.40.5-0.50.2-0.60.6-1.2
Bone: endosteal estimation0.20.41.00.20.40.3-0.2-0.70.8-0.71.0
Bone: endosteal perimeter0.81.62.7-1.7-1.4-1.51.61.1-0.91.2-0.2
Epididymis fat weight0.10.10.30.60.50.4-0.3-0.30.10.3-0.4
Delta time in closed arm before/after self-admin0.10.10.3-0.1-0.5-0.40.00.2-0.2-0.10.3
Delta time in open arm before/after self-admin0.20.20.30.10.60.4-0.1-0.50.5-0.40.4
Diff in mean of infusions in LGA sessions0.80.93.20.6-0.40.3-0.61.0-1.20.5-1.8
Delay discount exponential model param1.01.12.61.51.01.6-1.3-0.70.4-0.4-0.6
Extinction: sum of active levers before priming0.40.40.80.30.40.2-0.1-0.60.8-0.90.9
Active lever presses in extinction session 60.90.91.90.51.00.2-0.1-1.21.3-1.01.4
Bone: final force0.50.81.91.20.71.2-1.0-0.1-0.40.5-1.4
Bone: final moment0.61.02.51.30.71.3-1.1-0.1-0.40.5-1.6
Food consumed during 24 hour testing period0.70.91.61.31.21.1-1.2-0.90.6-0.3-0.1
Glucose0.71.11.70.61.00.7-0.6-1.31.3-1.31.3
Heart weight1.31.83.92.01.21.9-1.9-0.5-0.10.1-1.4
Delay discount hyperbolic model param1.01.02.41.51.01.6-1.3-0.60.3-0.3-0.6
Intermittent access intake day 1-15 change2.42.34.3-1.2-1.3-1.01.31.7-1.81.6-2.1
Intermittent access intake escalation2.02.03.3-1.1-1.2-1.01.31.5-1.61.4-1.8
Intermittent access intake escalation 21.41.43.7-0.7-0.8-0.50.91.2-1.51.3-1.9
Intermitt. access day 1 inactive lever presses0.00.00.10.10.10.1-0.10.0-0.2-0.1-0.3
Intermitt. access day 15 inactive lever presses1.51.72.7-1.0-1.1-0.71.01.5-1.61.6-1.6
Intermitt. access escalation Index0.30.20.90.10.40.2-0.1-0.50.6-0.41.0
Intermittent access day 1 total infusions0.00.00.10.1-0.10.1-0.1-0.10.3-0.10.0
Intermittent access day 15 total infusions0.60.71.1-0.8-0.8-0.70.90.9-0.80.8-1.1
Intermittent access terminal intake (last 3 days)0.20.30.5-0.6-0.5-0.40.70.4-0.30.4-0.7
Intermittent access total infusions0.40.40.6-0.8-0.7-0.70.80.6-0.40.5-0.6
Intermittent access day 1 locomotion0.00.00.1-0.2-0.1-0.20.1-0.00.3-0.10.2
Intermittent access day 15 total locomotion0.60.61.4-1.2-0.8-1.11.20.2-0.0-0.10.5
Intermittent access total locomotion0.60.71.7-1.3-0.8-1.21.30.30.0-0.00.6
Intermittent access standard deviation1.11.25.4-0.2-0.5-0.10.60.9-1.21.0-2.3
Left kidney weight0.92.43.91.51.91.2-1.3-2.01.6-1.61.3
Right kidney weight0.41.22.50.71.20.5-0.5-1.51.3-1.11.6
Cocaine induced anxiety0.30.30.9-0.0-0.4-0.1-0.10.7-0.70.7-1.0
Post-drug Anxiety0.10.10.30.1-0.30.0-0.30.5-0.40.4-0.6
Baseline Anxiety0.50.51.1-1.0-0.7-0.91.00.5-0.40.50.1
Tail length4.714.222.94.84.24.5-4.5-3.63.0-3.01.0
Length with tail5.520.034.85.95.25.5-5.5-4.23.3-3.10.5
Length without tail3.16.912.63.63.13.4-3.2-2.41.8-1.3-0.2
Times rat made contact with spout0.40.40.90.90.70.9-0.9-0.40.3-0.2-0.3
Lifetime Intake0.30.30.6-0.8-0.7-0.70.80.4-0.20.2-0.3
Liver weight, left0.81.23.20.50.60.5-0.6-1.11.5-1.31.8
Liver weight, right1.83.04.11.61.81.6-1.6-2.02.0-1.71.6
Locomotor activity4.06.410.53.22.93.0-3.1-2.52.0-1.80.7
Locomotor testing distance3.55.89.33.02.82.7-2.8-2.42.1-1.70.8
Locomotor testing rearing0.10.10.20.40.20.4-0.5-0.30.3-0.10.1
Locomotion in novel chamber0.30.40.8-0.3-0.5-0.40.50.7-0.80.9-0.8
Locomotion in novel chamber post-restriction0.70.91.30.81.00.6-0.6-1.11.0-1.11.0
Fecal boli incidents, locomotor time 10.40.51.21.10.41.0-1.0-0.40.3-0.5-0.2
Change in fecal boli incidents, locomotor task0.10.10.2-0.20.3-0.20.0-0.20.3-0.20.5
Time >=10cm from walls, locomotor time 10.40.40.9-0.8-0.3-1.00.9-0.10.2-0.30.8
Bouts of movement, locomotor time 10.10.10.20.40.30.5-0.5-0.10.1-0.4-0.1
Total resting periods, locomotor time 10.10.10.20.30.20.4-0.4-0.10.0-0.4-0.1
Rest time, locomotor task time 10.20.20.5-0.5-0.7-0.40.50.4-0.3-0.10.2
Distance moved, locomotor task time 10.50.61.11.11.00.9-1.0-0.60.20.0-0.5
Vertical activity count, locomotor time 10.50.61.11.00.91.1-0.9-0.70.4-0.3-0.0
Time >=10cm from walls, locomotor time 20.80.91.41.21.00.9-1.0-1.00.8-0.80.4
Bouts of movement, locomotor time 20.30.41.0-0.5-0.3-0.20.30.6-0.61.0-0.8
Total resting periods, locomotor time 20.50.51.2-0.7-0.6-0.40.50.7-0.71.1-0.7
Rest time, locomotor task time 20.10.10.20.2-0.10.3-0.4-0.10.1-0.30.4
Distance moved, locomotor task time 20.20.20.60.60.80.5-0.4-0.40.20.3-0.5
Vertical activity count, locomotor time 20.00.00.2-0.10.2-0.00.2-0.10.00.4-0.1
Light reinforcement 10.50.81.51.21.01.2-1.1-0.90.6-0.70.2
Light reinforcement 20.10.20.7-0.4-0.1-0.30.4-0.30.2-0.40.8
Bone: marrow area0.20.41.00.30.50.4-0.3-0.70.9-0.81.0
Bone: maximum diameter1.01.93.2-0.9-1.2-0.70.81.5-1.71.8-1.8
Bone: maximum force0.30.51.21.10.71.1-0.9-0.30.1-0.0-0.7
Bone: maximum moment0.40.61.31.10.71.1-1.0-0.3-0.00.1-0.9
Mean time between licks in bursts1.21.72.7-1.6-1.3-1.51.51.2-1.01.6-0.4
Mean num. licks in bursts1.62.02.91.11.50.9-1.0-1.71.7-1.41.6
Cd content in liver1.41.63.31.81.11.8-1.8-0.80.6-0.7-0.4
Co content in liver0.40.51.3-0.3-0.5-0.40.30.8-0.90.8-1.1
Cu content in liver4.25.16.62.62.22.6-2.5-2.22.1-2.41.3
Fe content in liver1.31.53.11.71.01.8-1.7-0.80.8-0.9-0.1
K content in liver1.01.01.51.21.11.1-1.1-1.00.8-1.00.5
Mg content in liver0.00.00.10.20.20.1-0.1-0.20.0-0.30.1
Mn content in liver1.11.21.90.61.30.5-0.5-1.41.4-1.11.4
Na content in liver0.91.01.70.80.70.8-0.8-1.01.2-1.31.1
Rb content in liver0.50.71.61.20.41.3-1.3-0.20.4-0.5-0.5
Se content in liver0.10.10.20.50.40.5-0.4-0.2-0.1-0.1-0.1
Sr content in liver0.00.00.1-0.00.2-0.10.1-0.2-0.10.00.0
Zn content in liver4.04.46.42.52.32.4-2.4-2.11.8-1.90.9
Bone: minimum diameter0.61.11.7-1.0-1.0-1.01.11.0-1.11.3-0.8
Time in familiar zone, hab. session 11.41.32.3-1.0-1.5-1.00.91.5-1.30.9-0.8
Time in novel zone, hab. session 10.40.40.90.71.00.7-0.6-0.80.7-0.40.1
Total zone transitions, hab. session 10.60.91.60.61.20.5-0.5-1.31.2-0.91.0
Total locomotion distance, hab. session 10.30.40.70.60.80.5-0.6-0.80.7-0.60.5
Locomotion velocity, hab. session 10.50.71.00.70.90.6-0.6-1.01.0-0.90.8
Time in familiar zone, hab. session 21.31.32.0-0.8-1.2-0.80.71.4-1.41.4-1.3
Time in novel zone, hab. session 20.40.40.90.10.40.2-0.0-0.70.8-0.71.0
Total zone transitions, hab. session 20.00.00.10.00.30.00.1-0.30.00.20.0
Total locomotion distance, hab. session 20.40.50.70.80.80.7-0.7-0.80.6-0.70.5
Locomotion velocity, hab. session 20.30.50.60.70.80.6-0.6-0.80.7-0.70.6
Novel to familiar place preference ratio3.63.77.70.91.61.0-0.8-2.32.5-2.42.8
Novelty place preference4.04.18.80.91.71.0-0.8-2.42.7-2.53.0
Time in novel zone, NPP test3.94.07.61.01.71.1-0.9-2.32.6-2.52.8
Total zone transitions, NPP test2.23.14.91.72.21.5-1.4-2.21.9-1.61.4
Total locomotion distance, NPP test0.91.31.91.31.41.2-1.2-1.31.0-1.00.4
Locomotion velocity, NPP test1.11.62.41.41.51.2-1.2-1.51.2-1.20.7
Intraocular pressure1.52.12.81.41.11.4-1.7-1.31.6-1.61.3
Delta distance traveled before/after self-admin0.10.10.3-0.30.2-0.20.3-0.20.3-0.40.5
Delta ambulatory time before/after self-admin0.60.61.10.61.00.6-0.6-0.90.9-0.90.8
Parametrial fat weight1.02.02.51.61.61.2-1.4-1.61.5-1.40.9
Pavlov. Cond. lever latency4.55.77.02.62.62.6-2.5-2.42.4-2.31.4
Pavlov. Cond. magazine entry latency6.38.19.6-3.0-3.1-3.02.83.0-2.92.8-2.0
Pavlov. Cond. change in total contacts1.82.02.5-1.4-1.6-1.41.31.6-1.51.4-1.1
Pavlov. Cond. index score6.17.89.3-2.9-3.1-2.92.83.0-2.92.6-2.0
Pavlov. Cond. latency score5.77.38.6-2.9-2.9-2.92.82.8-2.72.6-1.7
Pavlov. Cond. lever contacts2.53.03.5-1.9-1.9-1.91.81.8-1.81.6-1.1
Pavlov. Cond. magazine entry number6.68.210.33.13.23.1-2.9-3.12.8-2.61.8
Pavlov. Cond. intertrial magazine entries0.30.40.50.60.60.7-0.6-0.70.6-0.70.5
Pavlov. Cond. lever-magazine prob. diff.6.27.79.3-2.7-3.0-2.72.63.1-3.02.7-2.3
Pavlov. Cond. response bias6.98.49.9-3.0-3.1-3.02.83.1-3.02.8-2.1
Pavlov. Cond. lever latency0.10.10.3-0.4-0.6-0.30.40.4-0.20.00.2
Pavlov. Cond. magazine entry latency0.30.40.7-0.5-0.5-0.60.50.6-0.80.7-0.8
Pavlov. Cond. change in total contacts0.91.32.51.61.41.4-1.5-1.00.6-0.2-0.4
Pavlov. Cond. index score0.10.20.70.10.0-0.1-0.00.3-0.50.7-0.9
Pavlov. Cond. latency score0.10.20.60.00.0-0.20.00.3-0.50.6-0.8
Pavlov. Cond. lever contacts0.50.61.20.91.10.7-0.8-0.90.7-0.50.2
Pavlov. Cond. magazine entry number0.60.70.90.80.80.9-0.8-0.91.0-0.90.8
Pavlov. Cond. intertrial magazine entries0.20.30.6-0.8-0.8-0.60.70.6-0.20.10.1
Pavlov. Cond. lever-magazine prob. diff.0.20.20.80.00.0-0.10.00.3-0.60.8-0.9
Pavlov. Cond. response bias0.10.10.3-0.00.1-0.20.10.2-0.30.6-0.6
Time in closed arm before self-admin0.50.61.10.61.00.9-0.7-0.80.7-0.9-0.0
Time in closed arm after self-admin0.10.10.1-0.0-0.3-0.1-0.20.2-0.30.3-0.3
Time in open arm before self-admin0.50.60.8-0.7-0.9-0.90.80.8-0.80.8-0.3
Time in open arm after self-admin0.60.72.5-0.70.2-0.30.7-0.60.8-0.81.6
Bone: periosteal estimation0.10.10.4-0.1-0.20.00.10.3-0.40.5-0.6
Bone: periosteal perimeter1.32.23.2-1.5-1.6-1.41.51.5-1.51.8-1.1
Bone: post-yield work0.00.00.20.20.20.2-0.1-0.20.1-0.40.1
Progressive ratio test 1 active lever presses0.30.30.7-0.10.3-0.30.1-0.60.8-0.70.9
Progressive ratio test 1 breakpoint0.30.30.7-0.20.2-0.30.1-0.50.8-0.60.9
Progressive ratio test 1 inactive lever presses0.70.71.2-0.6-0.8-0.70.51.0-0.91.0-1.1
Progressive ratio test 2 active lever presses0.50.61.0-1.0-0.8-1.01.00.6-0.50.5-0.4
Progressive ratio test 2 breakpoint0.40.40.7-0.8-0.7-0.80.80.6-0.50.5-0.5
Progressive ratio test 2 inactive lever presses3.23.75.9-1.4-1.7-1.31.42.2-2.22.4-2.3
Incentive Sensitization - Responses1.51.51.9-1.2-1.3-1.21.21.4-1.31.3-1.1
Incentive Sensitization - Breakpoint1.51.51.9-1.2-1.3-1.21.21.4-1.31.3-1.1
Sum of active levers in priming session hrs 5-60.80.71.00.81.00.9-0.4-1.01.0-1.00.7
Progressive ratio3.03.44.82.22.22.1-1.8-2.11.8-1.21.1
Food seeking constrained by brief footshock1.11.32.2-1.5-0.9-1.31.50.9-1.01.4-0.4
Seeking ratio, punishment vs. effort5.26.48.8-3.0-2.8-2.82.62.7-2.52.1-1.5
Retroperitoneal fat weight0.31.11.81.11.20.9-0.9-1.31.2-0.90.9
Reaction time number correct0.71.01.9-1.1-1.0-1.11.10.9-0.91.4-0.5
Reaction time mean minus median0.10.20.30.50.40.4-0.5-0.40.3-0.20.2
Reaction time mean minus median AUC0.40.50.80.80.80.7-0.9-0.70.6-0.60.6
Reaction time num false alarms0.20.20.5-0.7-0.5-0.50.70.3-0.00.10.2
Reaction time num false alarms AUC0.10.10.4-0.4-0.1-0.20.4-0.10.4-0.40.6
Reaction time trials correct on left0.71.01.9-1.1-1.0-1.11.10.9-0.91.4-0.5
Reaction time trials on left0.71.11.8-1.1-1.0-1.11.10.9-0.91.3-0.4
Reaction time mean0.00.10.2-0.00.0-0.10.2-0.20.3-0.40.5
Reaction time mean AUC0.10.20.5-0.10.1-0.20.2-0.30.5-0.50.7
Median of all reaction times0.10.10.3-0.2-0.0-0.30.5-0.20.3-0.30.5
Reaction time omissions0.10.20.4-0.5-0.6-0.40.60.3-0.0-0.00.2
Reaction time false alarm rate0.10.10.5-0.00.10.2-0.0-0.20.5-0.70.5
Reaction time premature initiation rate1.52.13.41.61.81.5-1.3-1.51.4-1.40.6
Reaction time premature initiations0.40.61.40.81.20.8-0.6-0.90.8-0.50.2
Std. dev. reaction times0.30.40.80.40.60.3-0.3-0.80.8-0.80.9
Reaction time trials completed0.71.11.8-1.1-1.0-1.11.10.9-0.91.3-0.4
Reaction time trials AUC0.91.32.0-1.3-1.1-1.31.31.0-0.91.4-0.4
Run reversals in cocaine runway, females2.62.53.6-1.9-1.6-1.71.61.6-1.71.4-1.0
Run reversals in cocaine runway, males0.40.40.90.90.50.9-0.7-0.2-0.0-0.1-0.8
Latency to leave start box in cocaine runway0.50.51.31.10.60.9-1.1-0.50.4-0.3-0.0
Latency to leave start box in cocaine runway, F0.80.92.01.40.71.2-1.4-0.3-0.10.0-1.0
Latency to leave start box in cocaine runway, M0.30.21.2-0.20.1-0.00.1-0.40.7-0.31.1
Std. dev. time between licks in bursts6.07.29.1-2.6-2.9-2.42.43.0-2.92.7-2.3
Total sessions with >9 infusions0.70.72.0-0.3-0.8-0.40.21.0-1.00.9-1.4
Short access day 1 total inactive lever presses4.65.27.3-2.5-2.6-2.72.12.4-2.12.1-1.4
Short access day 10 total inactive lever presses1.01.14.20.2-0.40.1-0.21.1-1.41.0-2.1
Short access day 1 total infusions0.90.91.5-1.0-1.2-1.10.61.1-1.00.9-0.7
Short access day 10 total infusions0.10.10.3-0.5-0.2-0.40.6-0.00.2-0.20.1
Short access total infusions0.50.51.2-1.1-0.8-1.11.00.4-0.20.20.1
Short access day 1 locomotion0.00.00.1-0.2-0.2-0.10.10.1-0.3-0.1-0.3
Short access day 10 total locomotion0.30.30.8-0.10.3-0.20.1-0.70.7-0.90.9
Short access total locomotion0.40.41.2-0.00.3-0.0-0.2-0.70.8-1.11.0
One hour access (0.3 mA shock)0.20.20.5-0.7-0.3-0.60.7-0.00.2-0.20.5
Compulsive drug intake0.30.31.9-0.3-0.0-0.30.1-0.40.5-0.41.4
One hour access (shock baseline)0.10.10.6-0.2-0.2-0.10.40.2-0.10.1-0.8
Social response proportion0.20.30.50.50.60.5-0.4-0.60.5-0.70.2
Social responses0.40.50.70.80.80.8-0.8-0.80.8-0.50.5
Social time1.62.14.1-0.8-1.3-0.70.81.5-1.72.0-1.9
Soleus weight2.26.311.83.42.93.2-3.2-2.21.6-1.6-0.1
Bone: stiffness0.10.10.30.40.30.5-0.3-0.30.3-0.2-0.0
Tibialis anterior weight0.10.20.90.0-0.2-0.00.10.4-0.60.7-1.0
Time to tail flick, vehicle, before self-admin1.51.52.41.51.21.4-1.6-1.21.0-1.30.3
Time to tail flick, vehicle, after self-admin0.50.51.30.80.50.9-0.8-0.0-0.20.4-1.1
Time to tail flick, test, before self-admin1.21.12.50.50.80.2-0.4-1.21.3-1.61.6
Time to tail flick, test, after self-admin0.20.20.6-0.2-0.3-0.20.20.5-0.50.3-0.7
Delta time to tail flick, vehicle, before/after SA1.11.12.1-0.7-0.9-0.60.81.2-1.21.4-1.4
Delta time to tail flick, test, before/after SA0.70.61.0-0.6-0.8-0.60.60.9-0.90.8-1.0
Tibia length4.111.519.94.54.24.1-4.0-3.32.4-2.20.3
Ambulatory time before self-admin1.01.01.4-0.8-0.8-0.71.21.0-1.11.1-1.2
Ambulatory time after self-admin0.40.41.5-1.10.0-0.61.20.1-0.00.60.2
Bone: tissue strength1.31.22.61.61.11.6-1.5-0.50.2-0.4-1.0
Total heroin consumption0.50.61.21.11.00.9-1.0-0.40.1-0.3-0.6
Bone: trabecular number0.50.82.3-1.2-0.3-1.11.1-0.20.5-0.11.5
Bone: trabecular spacing0.81.12.41.50.61.4-1.4-0.0-0.40.1-1.5
Bone: trabecular thickness0.50.51.80.20.70.1-0.1-0.90.9-0.61.3
Bone: trabecular tissue density0.40.60.90.80.70.7-0.7-0.80.8-1.00.6
Water consumed over 24 hours0.50.62.10.0-0.30.0-0.00.8-1.01.1-1.5
Number of responses in last shaping day0.91.01.4-0.7-1.0-0.80.61.2-1.11.2-1.1