Hub : Genes

Celsr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Celsr1 0.07 0.04 6.7e-07 0.03 0.05 0.05 0.04 1.8e-04 1.7e-06 5.8e-06 1.2e-05
2 BLA mRNA stability Celsr1 0.11 0.08 3.0e-04 0.05 0.04 0.04 0.05 1.0e-03 4.2e-03 3.5e-03 1.4e-03
3 NAcc mRNA stability Celsr1 0.07 0.05 2.1e-07 0.06 0.06 0.05 0.06 2.9e-07 1.2e-07 7.1e-07 7.2e-08
4 IL mRNA stability Celsr1 0.13 0.09 6.9e-03 0.07 0.07 0.02 0.03 9.4e-03 1.1e-02 1.2e-01 6.0e-02
5 Adipose mRNA stability Celsr1 0.11 0.06 3.0e-13 0.09 0.09 0.08 0.09 4.0e-10 8.3e-10 1.5e-09 9.7e-10
6 Brain gene expression Celsr1 0.18 0.08 1.7e-15 0.1 0.14 0.14 0.12 3.8e-09 1.1e-12 6.3e-13 1.7e-11
7 Brain mRNA stability Celsr1 0.22 0.09 0.0e+00 0.22 0.2 0.23 0.09 3.8e-20 1.9e-18 5.2e-21 1.6e-08
8 NAcc gene expression Celsr1 0.08 0.04 2.6e-08 0.06 0.07 0.06 0.07 2.6e-07 4.2e-08 1.5e-07 4.3e-08
9 LHb gene expression Celsr1 0.27 0.16 6.4e-04 0.08 0.08 0.1 0.08 6.5e-03 5.5e-03 2.6e-03 5.7e-03
10 RMTg mRNA stability Celsr1 0.18 0.15 3.9e-03 0.12 0.03 0.05 0.01 3.9e-04 5.7e-02 1.8e-02 1.6e-01
11 IL gene expression Celsr1 0.25 0.15 4.3e-04 0.08 0.15 0.1 0.12 5.2e-03 1.8e-04 2.4e-03 8.0e-04
12 PL gene expression Celsr1 0.04 0.02 9.6e-04 0.03 0.03 0.02 0.02 7.1e-04 3.1e-04 3.1e-03 1.1e-03
13 BLA gene expression Celsr1 0.16 0.1 2.4e-04 0.05 0.04 0.02 0.04 8.7e-04 4.4e-03 1.9e-02 2.0e-03
14 pVTA gene expression Celsr1 0.12 0.07 5.2e-04 0.11 0.05 0.07 0.08 2.5e-05 2.7e-03 3.6e-04 1.9e-04
15 Adipose isoform ratio XM_006242167.4 0.39 0.19 7.2e-03 0.01 0 0.04 0 3.1e-02 2.3e-01 4.7e-05 2.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.50.81.91.1-0.91.2-1.0-1.4-0.5-1.20.8-0.9-1.40.60.30.1-0.3-1.0
Area under the delay curve3.43.66.82.3-2.62.3-2.4-2.4-2.0-1.91.9-1.8-1.61.21.0-0.9-1.2-1.6
BMI with tail2.78.812.0-3.23.5-3.33.23.43.03.2-3.23.32.8-3.4-2.81.72.01.3
BMI without tail0.91.94.8-2.21.3-2.11.71.80.61.4-0.91.42.1-0.80.0-0.5-0.70.8
Body weight1.46.014.6-3.83.5-3.63.33.31.82.3-2.22.32.3-1.8-0.9-0.2-0.11.0
Weight adjusted by age2.12.44.4-1.51.2-1.82.02.11.81.6-1.71.81.2-1.3-1.11.30.91.2
Bone surface0.20.30.80.6-0.60.6-0.5-0.8-0.2-0.70.5-0.4-0.90.40.40.1-0.20.1
Bone volume0.40.61.50.8-0.90.8-0.8-1.2-0.7-0.90.8-0.7-0.90.70.6-0.2-0.4-0.6
Breakpoint value in progressive ratio session0.40.41.30.60.10.4-0.3-0.30.70.3-0.50.40.2-0.9-1.11.10.9-0.7
Number of licking bursts0.81.02.30.2-0.60.3-0.6-0.6-1.2-1.01.3-1.1-0.81.31.4-1.5-1.3-0.2
Context. condit. distance diff. score0.91.12.8-0.91.2-1.01.01.00.91.6-1.31.11.7-0.7-0.60.60.61.1
Locomotion velocity, session 10.70.72.5-1.60.8-1.41.31.20.40.4-0.30.30.70.20.6-0.5-1.20.2
Locomotion distance, session 10.50.71.70.2-0.90.4-0.5-0.5-0.9-0.90.9-0.8-0.41.21.3-0.9-1.3-0.3
Locomotion velocity, session 21.72.06.5-2.51.9-2.21.81.80.61.1-0.71.01.9-0.50.2-1.0-0.70.5
Locomotion distance, session 20.10.10.30.5-0.40.5-0.5-0.6-0.0-0.20.10.0-0.2-0.2-0.30.30.30.1
Locomotion velocity, session 31.41.74.0-1.91.0-1.51.10.9-0.50.50.30.12.01.01.7-2.0-1.80.6
Locomotion distance, session 30.91.03.5-0.4-0.2-0.1-0.2-0.4-1.2-0.81.1-0.90.11.31.7-1.9-1.5-0.3
Stereotopy head waving bouts, day 30.80.93.4-0.80.4-1.10.91.00.71.4-0.81.01.8-0.6-0.20.3-0.31.4
Stereotopy head waving duration, day 31.92.35.9-1.30.8-1.61.51.51.32.1-1.51.72.4-1.1-0.50.80.02.4
Locomotion velocity, session 70.80.93.4-1.30.7-1.10.60.7-0.31.0-0.20.61.80.10.7-1.2-0.81.3
Locomotion distance, session 70.20.21.4-0.60.6-0.3-0.0-0.0-0.60.00.3-0.40.20.40.6-1.2-0.5-0.0
Stereotopy head waving bouts, day 70.80.93.8-1.10.8-1.21.00.90.61.2-0.80.92.0-0.40.0-0.0-0.41.3
Stereotopy head waving duration, day 70.30.41.6-0.70.4-0.60.50.40.20.8-0.40.61.3-0.10.2-0.2-0.50.9
Locomotion velocity, session 84.25.08.6-2.52.6-2.62.72.52.32.5-2.42.32.9-2.0-1.61.21.01.3
Locomotion distance, session 80.30.41.5-0.90.9-0.80.80.70.50.9-0.60.51.2-0.2-0.1-0.10.10.2
Degree of sensitization distance1.41.42.5-0.81.4-0.91.01.11.41.4-1.41.10.7-1.4-1.61.21.30.3
Degree of sensitization stereotypy0.40.41.3-0.80.7-0.80.80.60.50.7-0.60.71.1-0.3-0.00.1-0.00.6
Conditioned locomotion0.00.00.3-0.20.4-0.10.10.1-0.00.1-0.20.30.1-0.1-0.0-0.10.10.5
Cocaine response after cond. corrected0.40.40.9-1.00.7-0.60.50.4-0.1-0.50.3-0.4-0.90.30.4-0.8-0.9-1.0
Cocaine response after cond. not corrected0.70.82.8-0.80.3-0.30.10.0-0.7-0.80.7-0.8-0.90.81.0-1.4-1.7-1.2
Cocaine response before conditioning0.50.61.00.5-0.80.6-0.8-0.8-1.0-0.70.9-0.8-0.20.90.9-0.9-0.9-0.6
Saline control response0.30.31.1-0.50.8-0.40.80.70.6-0.3-0.5-0.0-0.8-0.0-0.40.40.3-1.1
Bone: connectivity density0.40.61.20.7-0.70.7-0.7-0.9-0.6-1.00.9-0.8-1.10.80.7-0.3-0.9-0.3
Bone: cortical apparent density0.60.82.21.5-1.21.3-1.2-1.1-0.7-0.80.8-0.7-0.80.50.2-0.00.50.3
Bone: cortical area1.62.43.6-1.41.7-1.71.91.61.91.5-1.81.71.1-1.6-1.51.41.50.8
Bone: cortical porosity1.61.83.1-1.31.8-1.41.71.61.80.9-1.41.00.6-1.3-1.51.21.1-0.6
Bone: cortical porosity1.61.73.1-1.21.6-1.31.71.61.81.0-1.41.00.7-1.4-1.51.31.2-0.3
Bone: cortical thickness0.30.52.00.20.4-0.10.40.30.90.3-0.70.6-0.2-0.8-1.11.21.40.2
Bone: cortical thickness3.13.56.0-1.01.7-1.51.91.72.51.9-2.21.91.1-2.0-2.22.32.21.6
Bone: cortical tissue density0.40.61.81.3-1.01.2-1.0-1.0-0.5-0.60.7-0.6-0.70.40.20.00.50.5
Condit. Reinf. active minus inactive responses0.30.42.10.3-0.40.3-0.00.0-0.2-0.80.6-0.8-1.00.40.2-0.2-0.3-1.5
Condit. Reinf. active-inactive response ratio0.70.71.61.2-1.21.0-0.7-0.6-0.6-1.00.9-1.2-1.30.80.4-0.2-0.2-0.7
Condit. Reinf. active responses1.41.74.70.5-0.90.9-0.8-0.9-1.3-1.51.4-1.6-1.41.31.1-1.3-1.5-2.2
Condit. Reinf. inactive responses1.11.33.1-0.1-0.30.6-0.8-1.0-1.3-1.01.2-1.1-0.61.21.3-1.6-1.8-1.7
Incentive salience index mean0.50.63.2-0.80.2-0.50.70.7-0.1-0.70.5-0.7-0.70.60.6-0.9-1.0-1.8
Condit. Reinf. lever presses0.91.13.5-1.91.0-1.41.31.3-0.0-0.30.2-0.3-0.00.60.9-1.4-1.4-1.4
Condit. Reinf. active minus inactive responses0.60.71.4-0.60.8-0.91.01.01.20.5-0.80.70.4-0.9-1.00.90.6-0.6
Condit. Reinf. active-inactive response ratio0.10.20.3-0.20.2-0.40.50.40.60.1-0.30.3-0.4-0.4-0.50.60.50.1
Condit. Reinf. active responses1.62.23.3-1.41.6-1.61.71.71.81.3-1.61.61.4-1.6-1.51.30.8-0.4
Condit. Reinf. inactive responses2.32.95.0-1.92.0-1.91.81.91.81.9-1.91.92.2-1.8-1.51.10.40.0
Condit. Reinf. lever presses0.60.81.5-0.90.7-1.01.00.90.91.0-1.01.21.1-1.1-0.80.70.40.1
Condit. Reinf. lever reinforcers received1.11.62.5-1.11.4-1.31.41.41.61.0-1.31.31.1-1.4-1.41.20.8-0.6
Conditioned reinforcement - actives0.80.82.1-0.40.10.2-0.6-0.5-0.6-0.70.9-1.1-1.11.11.1-1.5-1.4-0.4
Conditioned reinforcement - inactives0.20.31.2-0.81.1-0.40.30.50.90.4-0.50.10.1-0.1-0.30.1-0.2-0.6
Conditioned locomotion0.91.14.0-2.01.6-1.51.31.40.90.8-0.90.70.5-0.5-0.2-0.3-0.5-0.0
Patch foraging indifference point 0 sec0.10.21.6-0.1-0.0-0.00.00.1-0.2-0.50.3-0.3-0.90.0-0.0-0.3-0.5-1.3
Patch foraging indifference point AUC0.20.31.10.4-0.80.4-0.5-0.2-0.6-0.70.6-0.4-0.20.30.3-0.60.0-1.1
Delay disc. indifference point, 0s delay0.10.10.5-0.2-0.10.1-0.3-0.2-0.30.00.10.0-0.0-0.10.0-0.3-0.7-0.1
Delay disc. indifference point, 16s delay3.13.16.32.4-2.52.3-2.2-2.1-1.7-1.91.8-1.6-2.01.20.9-0.4-0.7-0.8
Delay disc. indifference point, 2s delay0.50.51.41.0-1.21.0-1.0-0.9-0.7-0.50.6-0.6-0.60.30.1-0.2-0.4-0.9
Delay disc. indifference point, 24s delay0.20.20.80.1-0.30.00.20.20.5-0.1-0.20.1-0.1-0.6-0.70.40.3-0.9
Delay disc. indifference point, 4s delay3.84.010.72.6-3.32.6-2.8-2.5-2.3-1.72.0-1.7-1.41.10.9-0.8-1.3-1.0
Delay disc. indifference point, 8s delay3.03.15.92.3-2.42.2-2.4-2.4-1.9-1.71.7-1.7-1.41.00.8-0.7-0.9-1.4
Indifference point function ln k1.72.35.4-2.12.3-2.12.01.71.61.5-1.61.20.9-0.9-0.60.4-0.01.6
Indifference point function log k1.72.35.4-2.12.3-2.12.01.71.61.5-1.61.20.9-0.9-0.60.4-0.01.6
Patch foraging total patch changes 0 sec0.20.31.40.2-0.30.3-0.3-0.3-0.5-0.70.5-0.5-1.10.20.1-0.4-0.7-1.2
Patch foraging total patch changes 12 sec0.10.10.4-0.0-0.2-0.10.10.40.10.2-0.10.30.4-0.3-0.30.10.1-0.6
Patch foraging total patch changes 18 sec0.70.91.80.6-1.00.6-0.6-0.4-0.9-1.41.1-1.1-1.20.90.8-0.8-0.8-1.3
Patch foraging total patch changes 24 sec0.30.31.20.1-0.40.3-0.5-0.5-0.8-0.40.5-0.4-0.20.40.5-0.8-1.1-0.8
Patch foraging total patch changes 6 sec0.40.61.80.7-1.10.8-0.8-0.6-0.8-0.80.8-0.5-1.00.20.2-0.4-0.6-1.4
Patch foraging time to switch 0 sec0.20.30.80.9-0.60.5-0.5-0.40.10.3-0.00.40.9-0.2-0.20.70.80.5
Patch foraging water rate 0 sec0.30.41.0-0.90.6-0.91.01.00.60.5-0.70.60.2-0.7-0.60.30.10.0
Patch foraging water rate 12 sec0.40.72.7-1.31.0-0.90.80.6-0.2-0.40.1-0.5-0.90.30.5-0.9-1.6-0.8
Patch foraging water rate 18 sec0.20.20.7-0.70.2-0.60.80.50.2-0.3-0.0-0.2-0.70.10.1-0.1-0.8-0.5
Patch foraging water rate 24 sec0.40.61.2-0.81.1-0.81.10.81.00.5-0.90.40.2-0.7-0.90.7-0.1-0.3
Patch foraging water rate 6 sec0.50.71.9-0.3-0.2-0.20.20.2-0.7-1.00.9-1.1-0.71.11.1-1.1-1.4-0.7
Seeking ratio, delayed vs. immediate footshock0.70.81.91.3-1.01.4-1.4-1.3-0.8-1.00.7-0.6-1.10.40.10.10.40.3
Distance traveled before self-admin0.20.20.7-0.60.4-0.3-0.00.1-0.40.30.1-0.10.60.30.5-0.8-0.80.2
Distance traveled after self-admin0.91.01.3-1.01.1-0.81.00.91.11.1-1.11.11.1-1.0-0.90.80.9-0.5
Extensor digitorum longus weight0.31.12.1-1.41.5-1.21.01.00.81.2-1.01.11.0-0.8-0.40.20.31.4
Bone: elastic displacement0.30.31.2-1.10.7-0.70.50.7-0.1-0.00.0-0.20.10.30.5-0.8-0.9-0.7
Bone: elastic work2.93.85.5-2.12.3-2.22.42.32.22.1-2.22.02.1-1.8-1.61.41.10.8
Bone: endosteal estimation1.53.25.3-2.32.0-2.32.21.81.72.2-1.91.92.3-1.5-1.00.70.21.3
Bone: endosteal perimeter2.24.58.9-2.92.6-3.02.92.52.12.2-2.12.02.2-1.6-1.00.60.41.4
Epididymis fat weight0.20.41.2-1.01.1-0.80.70.80.30.3-0.40.3-0.2-0.2-0.2-0.2-0.1-0.9
Delta time in closed arm before/after self-admin0.30.30.90.20.1-0.10.20.50.60.5-0.50.50.3-0.6-0.70.80.90.4
Delta time in open arm before/after self-admin0.80.82.4-0.2-0.40.1-0.4-0.5-1.2-0.50.8-0.70.01.31.6-1.3-1.50.3
Diff in mean of infusions in LGA sessions0.80.93.1-0.01.0-0.30.70.31.30.5-1.00.7-0.4-1.4-1.81.41.0-1.0
Delay discount exponential model param3.63.87.0-2.32.6-2.42.52.42.12.0-2.01.91.6-1.3-1.01.01.31.7
Extinction: sum of active levers before priming0.30.31.60.6-0.10.8-0.7-0.60.2-0.1-0.00.0-0.5-0.4-0.70.50.5-1.3
Active lever presses in extinction session 61.31.33.3-0.71.1-0.80.80.51.21.4-1.31.41.0-1.8-1.71.11.00.1
Bone: final force1.83.05.8-0.61.4-0.91.30.92.11.6-2.12.11.1-2.3-2.42.42.30.5
Bone: final moment2.43.87.1-0.71.5-1.11.41.12.41.9-2.42.41.2-2.5-2.72.62.70.9
Food consumed during 24 hour testing period4.35.211.3-2.62.4-3.13.42.62.92.1-2.42.22.0-1.9-1.61.61.60.3
Glucose0.20.31.20.20.2-0.10.70.60.7-0.5-0.1-0.3-0.7-0.2-0.60.70.4-1.1
Heart weight0.30.51.41.1-0.70.6-0.8-0.50.20.5-0.30.5-0.1-0.5-0.60.90.71.2
Delay discount hyperbolic model param3.33.56.7-2.22.6-2.32.42.32.01.9-1.91.81.5-1.2-1.00.91.31.7
Intermittent access intake day 1-15 change0.40.41.3-0.40.9-0.30.70.71.1-0.2-0.4-0.2-0.60.1-0.40.70.5-0.8
Intermittent access intake escalation0.60.61.7-0.81.3-0.70.90.91.30.2-0.70.1-0.5-0.1-0.50.70.5-0.5
Intermittent access intake escalation 20.60.61.90.10.6-0.00.70.81.3-0.2-0.50.0-0.8-0.2-0.91.41.0-1.3
Intermitt. access day 1 inactive lever presses1.11.22.90.00.6-0.40.50.51.41.1-1.31.21.3-1.6-1.71.51.1-0.1
Intermitt. access day 15 inactive lever presses2.93.25.9-1.52.0-1.51.71.72.41.7-2.11.71.0-2.2-2.31.71.6-0.7
Intermitt. access escalation Index0.20.20.5-0.60.7-0.60.50.30.30.6-0.40.2-0.5-0.4-0.30.1-0.00.5
Intermittent access day 1 total infusions1.01.14.3-2.11.9-1.50.91.10.71.0-0.60.30.7-0.10.2-1.0-0.90.2
Intermittent access day 15 total infusions1.21.45.5-2.02.3-1.51.31.41.51.0-1.00.40.1-0.2-0.3-0.1-0.2-0.1
Intermittent access terminal intake (last 3 days)2.42.68.3-2.52.9-2.12.02.12.11.4-1.50.90.6-0.8-0.80.30.1-0.2
Intermittent access total infusions1.92.26.8-2.42.6-2.01.81.91.81.4-1.40.80.8-0.6-0.6-0.0-0.10.0
Intermittent access day 1 locomotion0.60.72.0-1.41.3-0.90.30.5-0.10.40.1-0.40.10.50.7-1.4-1.4-0.3
Intermittent access day 15 total locomotion1.01.14.3-2.02.1-1.50.91.00.71.0-0.60.00.60.20.3-0.9-1.10.2
Intermittent access total locomotion1.11.35.0-1.92.2-1.41.11.31.21.2-1.00.51.0-0.4-0.3-0.3-0.5-0.3
Intermittent access standard deviation1.01.12.5-0.61.3-0.71.11.21.60.8-1.10.70.7-0.9-1.31.21.2-0.5
Left kidney weight9.627.039.1-6.05.9-6.35.95.84.96.0-5.75.96.0-4.7-3.42.22.24.3
Right kidney weight9.927.838.4-5.65.9-6.15.96.05.36.2-5.85.96.1-5.0-3.92.82.83.6
Cocaine induced anxiety2.73.15.8-1.01.6-1.31.51.42.02.1-2.02.12.0-2.4-2.31.81.40.4
Post-drug Anxiety3.33.78.9-0.21.4-0.71.11.12.11.9-2.22.31.5-2.8-3.02.62.5-0.0
Baseline Anxiety0.80.83.21.1-0.81.2-1.0-0.9-0.8-1.10.8-0.9-1.80.80.4-0.00.4-0.4
Tail length1.03.08.5-0.2-1.20.1-0.5-0.6-2.1-1.51.9-1.7-0.52.42.8-2.7-2.9-0.7
Length with tail0.31.12.7-1.71.2-1.41.21.0-0.4-0.20.3-0.40.20.81.2-1.6-1.6-0.3
Length without tail1.02.16.6-1.62.6-1.51.81.81.71.0-1.51.10.2-1.3-1.50.91.3-0.4
Times rat made contact with spout0.30.30.9-0.90.6-0.80.50.4-0.10.40.10.20.70.20.7-0.8-0.40.7
Lifetime Intake1.92.26.3-2.52.5-2.01.82.01.71.5-1.30.81.1-0.6-0.4-0.2-0.30.3
Liver weight, left0.20.40.7-0.50.8-0.50.30.40.60.9-0.70.80.6-0.8-0.70.40.20.5
Liver weight, right0.71.24.4-1.51.1-1.00.60.5-0.7-0.10.5-0.50.60.91.4-2.1-2.0-0.3
Locomotor activity1.93.17.8-2.82.1-2.72.52.51.01.6-1.11.21.6-0.70.0-0.7-0.51.9
Locomotor testing distance0.30.61.6-1.30.7-1.20.91.00.20.6-0.30.30.2-0.10.3-0.7-0.61.2
Locomotor testing rearing0.50.72.0-1.41.0-1.20.91.10.30.7-0.50.60.9-0.10.4-0.5-0.21.2
Locomotion in novel chamber1.92.46.5-0.1-1.40.3-0.8-0.8-1.9-1.31.6-1.3-1.02.02.6-2.1-2.40.6
Locomotion in novel chamber post-restriction0.10.10.30.2-0.30.4-0.5-0.3-0.10.3-0.20.40.1-0.3-0.20.00.20.2
Fecal boli incidents, locomotor time 10.10.10.5-0.40.5-0.2-0.1-0.1-0.20.3-0.00.30.7-0.30.0-0.50.10.4
Change in fecal boli incidents, locomotor task0.40.40.90.3-0.90.2-0.2-0.3-0.5-0.80.6-0.6-0.60.80.8-0.4-0.7-0.6
Time >=10cm from walls, locomotor time 10.60.63.4-0.2-0.0-0.50.40.40.40.9-0.61.21.0-0.8-0.50.50.91.8
Bouts of movement, locomotor time 10.50.50.9-0.80.9-0.70.90.61.00.6-0.80.60.5-0.8-0.90.60.80.2
Total resting periods, locomotor time 10.60.61.6-0.30.7-0.40.60.31.00.6-0.90.70.2-1.1-1.31.11.20.4
Rest time, locomotor task time 10.40.41.1-0.80.7-0.70.50.60.40.8-0.60.81.1-0.7-0.40.1-0.20.6
Distance moved, locomotor task time 10.00.00.1-0.2-0.0-0.20.20.10.00.3-0.30.30.3-0.2-0.10.0-0.10.1
Vertical activity count, locomotor time 10.20.20.90.3-0.5-0.00.40.20.40.1-0.40.4-0.2-0.4-0.50.81.0-0.4
Time >=10cm from walls, locomotor time 21.01.12.0-0.60.8-0.70.91.21.30.9-1.11.3-0.1-1.3-1.31.31.40.1
Bouts of movement, locomotor time 20.50.61.81.3-0.91.3-1.2-0.9-0.3-0.30.2-0.20.0-0.2-0.60.50.7-0.6
Total resting periods, locomotor time 20.60.62.01.3-0.81.4-1.2-1.1-0.4-0.40.4-0.3-0.0-0.1-0.50.40.5-0.7
Rest time, locomotor task time 23.94.57.70.9-1.81.5-1.9-2.0-2.8-2.32.6-2.3-1.32.42.6-2.6-2.5-0.7
Distance moved, locomotor task time 23.03.45.1-1.82.0-1.92.02.12.12.2-2.32.11.8-1.8-1.71.51.10.7
Vertical activity count, locomotor time 23.94.26.2-1.82.0-2.02.42.52.52.3-2.52.31.6-2.1-2.02.01.60.2
Light reinforcement 10.30.62.2-1.50.4-1.20.70.9-0.50.3-0.10.40.70.10.8-1.2-1.00.5
Light reinforcement 22.02.76.5-2.52.4-2.42.12.21.31.5-1.51.51.6-1.3-0.8-0.00.40.3
Bone: marrow area1.53.25.2-2.22.1-2.32.11.81.82.2-1.91.92.2-1.6-1.10.80.31.3
Bone: maximum diameter5.09.214.4-3.43.5-3.73.83.53.33.3-3.33.22.9-2.8-2.31.81.61.8
Bone: maximum force2.54.38.0-0.71.5-1.21.61.22.62.1-2.62.51.7-2.7-2.82.82.50.9
Bone: maximum moment3.15.39.5-0.91.6-1.31.81.42.82.4-2.82.81.8-2.9-3.03.12.91.3
Mean time between licks in bursts0.91.32.20.9-1.51.1-1.2-1.2-1.2-1.21.3-1.1-1.51.31.3-0.9-1.0-0.0
Mean num. licks in bursts1.41.72.6-1.01.4-1.11.31.21.61.4-1.61.41.4-1.4-1.41.31.40.2
Cd content in liver0.20.20.80.6-0.30.6-0.4-0.30.0-0.40.1-0.3-0.9-0.1-0.40.40.3-0.5
Co content in liver0.50.61.7-1.20.7-1.31.31.20.60.7-0.50.50.5-0.20.0-0.1-0.3-0.2
Cu content in liver5.36.512.73.1-3.13.4-3.5-3.6-2.6-2.62.4-2.2-2.91.71.3-1.0-0.8-1.3
Fe content in liver0.30.41.5-0.60.8-0.50.70.70.80.1-0.50.40.1-0.5-0.60.50.8-1.2
K content in liver0.30.31.20.20.40.20.0-0.10.60.2-0.60.3-0.2-0.8-1.10.80.8-0.6
Mg content in liver0.30.31.40.30.40.4-0.1-0.20.50.0-0.40.2-0.6-0.8-1.20.90.8-0.7
Mn content in liver0.60.72.3-1.51.2-1.31.01.10.10.6-0.30.30.70.10.4-0.9-0.50.6
Na content in liver1.51.64.02.0-1.51.8-1.7-1.7-0.9-1.21.1-1.2-1.50.70.20.10.6-0.2
Rb content in liver0.40.51.11.0-0.80.9-0.8-0.80.1-0.2-0.10.1-0.9-0.4-0.71.01.0-0.1
Se content in liver0.30.41.4-0.20.10.1-0.2-0.5-0.6-0.80.5-0.8-0.80.70.7-0.9-1.2-0.6
Sr content in liver2.22.03.70.7-1.90.8-1.2-1.3-1.8-1.11.6-1.3-0.41.71.9-1.7-1.80.3
Zn content in liver1.01.11.80.8-1.01.0-1.0-1.0-1.0-1.31.1-1.0-1.01.11.0-0.6-1.3-1.1
Bone: minimum diameter1.01.94.3-2.11.9-2.02.11.81.31.3-1.31.11.4-0.8-0.50.2-0.00.2
Time in familiar zone, hab. session 10.90.81.6-1.21.1-1.31.11.10.91.0-1.00.90.9-0.9-0.50.40.10.8
Time in novel zone, hab. session 10.10.10.60.5-0.50.30.0-0.10.4-0.2-0.10.1-0.40.1-0.10.70.80.3
Total zone transitions, hab. session 11.31.83.41.8-1.81.8-1.7-1.7-1.1-1.51.2-1.3-1.51.20.8-0.2-0.3-0.5
Total locomotion distance, hab. session 10.20.30.80.1-0.40.2-0.4-0.4-0.6-0.20.4-0.6-0.00.80.8-0.7-0.90.2
Locomotion velocity, hab. session 10.30.41.1-0.0-0.40.1-0.4-0.4-0.8-0.30.6-0.60.10.91.0-1.0-1.00.1
Time in familiar zone, hab. session 20.20.20.9-0.70.3-0.3-0.00.1-0.4-0.30.3-0.3-0.60.60.7-0.9-0.2-0.3
Time in novel zone, hab. session 20.20.21.21.1-0.80.6-0.2-0.30.3-0.30.0-0.2-0.2-0.1-0.40.90.10.1
Total zone transitions, hab. session 20.40.61.4-0.10.4-0.20.30.30.90.7-1.00.90.4-1.0-1.11.21.00.5
Total locomotion distance, hab. session 20.10.10.4-0.30.4-0.30.30.40.40.4-0.40.30.3-0.4-0.40.20.60.3
Locomotion velocity, hab. session 20.10.10.3-0.30.3-0.30.30.30.30.3-0.30.30.3-0.3-0.30.10.50.2
Novel to familiar place preference ratio0.20.21.20.7-1.10.4-0.3-0.3-0.2-0.40.3-0.0-0.10.50.60.30.10.6
Novelty place preference0.20.20.70.4-0.90.10.0-0.0-0.1-0.20.20.10.20.60.70.2-0.00.8
Time in novel zone, NPP test0.20.21.00.5-1.00.2-0.10.0-0.1-0.20.20.10.20.60.70.30.11.0
Total zone transitions, NPP test0.71.12.81.3-1.01.6-1.7-1.5-1.0-1.00.9-0.9-0.90.70.4-0.3-0.2-0.7
Total locomotion distance, NPP test0.20.30.70.4-0.30.7-0.8-0.8-0.6-0.40.5-0.6-0.10.40.3-0.5-0.2-0.6
Locomotion velocity, NPP test0.40.51.00.4-0.30.7-1.0-1.0-1.0-0.50.7-0.7-0.20.60.5-0.9-0.5-0.8
Intraocular pressure0.71.04.3-1.31.0-0.70.30.1-0.6-0.20.5-0.60.20.71.1-1.8-2.1-1.0
Delta distance traveled before/after self-admin0.30.30.6-0.70.6-0.80.70.60.60.6-0.60.70.6-0.5-0.30.30.40.2
Delta ambulatory time before/after self-admin0.30.40.7-0.60.5-0.70.70.50.70.6-0.70.80.2-0.6-0.50.50.90.1
Parametrial fat weight1.12.15.00.2-1.20.6-1.1-1.1-2.1-1.11.7-1.4-0.31.41.8-2.1-2.2-1.2
Pavlov. Cond. lever latency0.60.82.11.4-0.91.1-1.2-1.1-0.30.6-0.10.40.5-0.4-0.50.71.01.5
Pavlov. Cond. magazine entry latency0.30.42.10.0-0.00.00.30.30.3-1.00.3-0.5-1.40.1-0.10.30.5-1.4
Pavlov. Cond. change in total contacts0.50.61.5-0.60.6-0.71.21.10.9-0.5-0.3-0.1-1.0-0.5-0.60.50.5-1.2
Pavlov. Cond. index score0.40.52.8-0.70.7-0.60.90.90.6-0.7-0.0-0.3-0.90.0-0.1-0.0-0.0-1.7
Pavlov. Cond. latency score0.40.51.9-1.00.8-0.81.11.00.7-0.5-0.2-0.1-0.7-0.0-0.10.0-0.1-1.4
Pavlov. Cond. lever contacts1.01.23.4-1.81.3-1.41.51.50.3-0.50.1-0.4-0.50.50.7-1.1-1.2-1.6
Pavlov. Cond. magazine entry number0.30.42.40.2-0.30.1-0.4-0.4-0.30.8-0.20.51.4-0.10.2-0.1-0.41.5
Pavlov. Cond. intertrial magazine entries0.81.02.20.9-0.81.1-1.0-1.0-0.9-1.21.0-1.2-1.50.80.5-0.6-0.8-1.3
Pavlov. Cond. lever-magazine prob. diff.0.40.53.2-0.60.5-0.50.70.70.3-0.90.2-0.6-1.10.30.2-0.3-0.4-1.8
Pavlov. Cond. response bias0.70.83.4-1.21.0-0.81.01.00.3-0.90.3-0.6-1.30.30.3-0.7-0.5-1.9
Pavlov. Cond. lever latency0.20.30.40.4-0.50.5-0.5-0.3-0.7-0.50.6-0.6-0.70.60.6-0.5-0.40.4
Pavlov. Cond. magazine entry latency1.01.23.11.7-0.91.5-1.1-1.30.3-0.4-0.10.2-0.6-0.8-1.31.51.8-0.8
Pavlov. Cond. change in total contacts1.01.44.30.40.2-0.30.70.41.60.7-1.11.20.7-1.6-1.82.12.0-0.2
Pavlov. Cond. index score0.40.51.70.6-0.20.3-0.1-0.30.70.2-0.50.60.1-0.9-1.11.31.3-0.5
Pavlov. Cond. latency score0.60.72.20.6-0.10.20.0-0.20.90.4-0.70.80.2-1.2-1.41.51.5-0.4
Pavlov. Cond. lever contacts0.70.91.8-0.40.7-0.60.70.51.30.9-1.11.10.8-1.3-1.31.31.2-0.2
Pavlov. Cond. magazine entry number0.50.62.0-1.20.6-0.80.50.8-0.4-0.10.3-0.5-0.20.71.0-1.3-1.4-0.2
Pavlov. Cond. intertrial magazine entries0.71.01.8-0.81.3-0.70.91.01.21.0-1.20.90.8-1.3-1.31.00.7-0.4
Pavlov. Cond. lever-magazine prob. diff.0.30.41.10.7-0.30.4-0.2-0.50.50.2-0.40.50.2-0.8-0.91.11.1-0.5
Pavlov. Cond. response bias0.50.61.80.20.2-0.00.2-0.01.00.6-0.80.90.4-1.1-1.31.41.3-0.3
Time in closed arm before self-admin0.50.62.40.7-0.00.8-0.4-0.40.4-0.90.1-0.4-1.50.0-0.60.80.6-1.5
Time in closed arm after self-admin0.10.10.4-0.00.3-0.20.40.50.70.1-0.30.2-0.3-0.1-0.30.50.60.3
Time in open arm before self-admin1.01.12.70.2-0.90.4-1.0-0.9-1.5-0.31.0-0.60.50.81.4-1.6-1.41.2
Time in open arm after self-admin0.70.82.40.4-1.00.6-1.1-1.2-1.5-0.10.8-0.40.80.61.0-1.2-1.20.5
Bone: periosteal estimation2.24.56.6-2.32.3-2.52.62.22.32.4-2.42.32.2-2.0-1.61.41.11.5
Bone: periosteal perimeter2.94.810.0-3.02.7-3.23.12.82.22.1-2.12.02.0-1.6-1.00.50.81.3
Bone: post-yield work0.40.61.51.2-1.10.8-0.6-0.80.3-0.1-0.20.4-0.3-0.7-0.81.21.10.7
Progressive ratio test 1 active lever presses0.91.04.2-1.71.0-0.90.20.3-0.40.30.4-0.6-0.10.71.1-2.1-1.7-0.1
Progressive ratio test 1 breakpoint0.91.04.3-1.71.0-0.80.10.3-0.40.20.4-0.6-0.10.71.1-2.1-1.8-0.3
Progressive ratio test 1 inactive lever presses0.30.41.1-0.80.7-0.4-0.2-0.1-0.20.7-0.1-0.00.60.00.4-1.0-1.10.9
Progressive ratio test 2 active lever presses0.20.31.0-0.51.0-0.3-0.10.00.70.7-0.40.00.3-0.4-0.6-0.20.2-0.9
Progressive ratio test 2 breakpoint0.20.30.9-0.40.9-0.3-0.00.10.70.8-0.40.10.4-0.5-0.6-0.10.3-0.8
Progressive ratio test 2 inactive lever presses0.80.93.0-1.01.7-0.80.40.71.41.4-1.10.60.7-0.9-1.10.10.6-0.4
Incentive Sensitization - Responses0.80.82.1-0.10.9-0.30.20.21.31.1-1.00.70.7-1.1-1.51.01.2-0.4
Incentive Sensitization - Breakpoint0.80.82.1-0.20.9-0.40.30.31.31.2-1.00.80.9-1.2-1.50.91.2-0.2
Sum of active levers in priming session hrs 5-60.60.61.60.30.2-0.00.2-0.11.00.7-0.70.70.7-1.0-1.31.21.1-0.6
Progressive ratio0.40.50.80.5-0.70.7-0.8-0.7-0.7-0.80.9-0.9-0.20.70.7-0.6-0.8-0.2
Food seeking constrained by brief footshock0.81.01.4-0.91.2-0.80.91.00.90.9-1.11.10.9-1.2-1.00.80.81.1
Seeking ratio, punishment vs. effort1.62.03.4-0.61.3-0.91.11.21.41.5-1.81.80.7-1.8-1.81.71.80.7
Retroperitoneal fat weight1.34.310.6-3.33.0-3.12.72.61.62.2-1.91.82.2-1.4-0.7-0.2-0.40.6
Reaction time number correct0.40.51.00.4-0.70.6-0.8-0.6-0.9-1.00.9-0.8-0.50.80.8-0.8-0.80.1
Reaction time mean minus median0.30.40.80.5-0.50.6-0.6-0.5-0.7-0.90.9-0.8-0.20.80.8-0.7-0.4-0.5
Reaction time mean minus median AUC0.50.61.70.2-0.40.5-0.8-0.7-1.2-0.50.9-0.60.60.71.1-1.3-1.10.2
Reaction time num false alarms0.50.61.8-0.50.0-0.20.20.0-0.5-0.60.7-0.9-0.51.21.3-1.4-1.3-0.5
Reaction time num false alarms AUC0.60.92.6-0.60.1-0.20.20.1-0.7-0.60.9-1.1-0.51.51.5-1.6-1.5-0.7
Reaction time trials correct on left0.40.51.00.4-0.70.6-0.8-0.6-0.9-1.00.9-0.8-0.50.80.8-0.8-0.80.1
Reaction time trials on left0.40.61.00.5-0.70.6-0.8-0.6-0.9-1.00.9-0.8-0.50.80.9-0.8-0.80.1
Reaction time mean1.01.44.32.1-1.41.9-1.6-1.7-0.7-1.10.9-0.9-1.00.3-0.20.70.5-1.1
Reaction time mean AUC1.31.74.72.2-1.62.1-1.8-1.9-0.9-1.21.0-1.0-1.00.50.00.50.2-1.2
Median of all reaction times1.31.85.52.4-1.62.2-1.7-1.9-0.6-1.10.7-0.8-1.30.2-0.51.10.7-1.5
Reaction time omissions0.70.92.11.5-1.31.3-1.2-1.3-0.7-1.10.8-0.8-1.30.50.10.20.6-0.1
Reaction time false alarm rate0.30.40.8-0.80.5-0.60.70.4-0.00.10.2-0.5-0.10.80.8-0.9-0.8-0.6
Reaction time premature initiation rate1.72.35.50.10.7-0.51.20.91.91.4-1.71.71.2-1.9-2.22.32.20.5
Reaction time premature initiations0.71.03.00.40.1-0.10.50.51.10.6-1.01.00.8-1.2-1.51.71.60.5
Std. dev. reaction times0.60.81.51.2-1.01.2-1.1-1.1-0.9-1.01.0-1.0-0.60.80.6-0.4-0.4-0.8
Reaction time trials completed0.40.61.00.5-0.70.6-0.8-0.6-0.9-1.00.9-0.8-0.50.80.9-0.8-0.80.1
Reaction time trials AUC0.20.30.60.2-0.40.3-0.5-0.3-0.7-0.70.6-0.5-0.20.50.6-0.6-0.60.2
Run reversals in cocaine runway, females0.90.92.4-0.0-1.1-0.0-0.0-0.1-0.9-0.90.9-1.0-1.61.31.4-1.0-1.40.2
Run reversals in cocaine runway, males0.60.61.9-1.00.1-0.70.30.4-0.4-0.10.5-0.50.50.91.3-1.4-1.20.7
Latency to leave start box in cocaine runway1.41.52.4-1.61.5-1.51.31.51.41.5-1.41.21.1-1.0-0.80.50.10.9
Latency to leave start box in cocaine runway, F0.70.71.3-1.11.1-1.10.90.90.91.1-0.90.80.5-0.6-0.40.30.11.1
Latency to leave start box in cocaine runway, M1.51.42.7-1.41.3-1.51.51.71.31.2-1.31.21.2-1.1-1.00.70.2-0.1
Std. dev. time between licks in bursts0.20.30.80.5-0.20.5-0.30.10.40.1-0.30.4-0.4-0.7-0.80.90.80.4
Total sessions with >9 infusions1.61.75.8-2.41.8-1.91.82.01.21.0-0.90.61.00.10.4-0.5-0.70.8
Short access day 1 total inactive lever presses2.12.34.7-2.22.0-1.81.61.91.71.8-1.71.51.2-1.3-0.90.40.40.9
Short access day 10 total inactive lever presses1.01.11.8-0.50.9-0.81.11.11.30.7-1.11.11.3-1.3-1.31.11.0-0.5
Short access day 1 total infusions1.31.33.6-1.91.1-1.71.51.61.11.0-0.80.61.20.00.4-0.4-0.71.5
Short access day 10 total infusions1.71.96.9-2.62.4-2.01.71.81.21.1-1.00.70.6-0.5-0.1-0.7-0.60.2
Short access total infusions2.83.28.2-2.92.5-2.42.22.41.91.9-1.71.41.7-1.0-0.5-0.0-0.10.8
Short access day 1 locomotion0.10.20.6-0.50.4-0.40.50.50.80.4-0.50.30.3-0.1-0.20.30.10.1
Short access day 10 total locomotion0.91.03.8-1.00.3-0.3-0.2-0.1-0.9-0.20.7-0.8-0.11.21.6-1.9-2.00.8
Short access total locomotion0.90.92.8-1.71.5-1.21.01.21.01.1-0.90.60.8-0.5-0.2-0.2-0.20.3
One hour access (0.3 mA shock)0.30.41.7-1.01.3-0.70.40.60.70.7-0.50.20.50.00.1-0.6-0.40.1
Compulsive drug intake0.50.51.91.4-0.80.9-0.5-0.50.20.1-0.20.3-0.1-0.4-0.71.31.00.2
One hour access (shock baseline)0.91.04.2-2.02.0-1.31.01.10.80.6-0.50.10.20.10.3-1.1-0.9-0.3
Social response proportion1.41.52.8-1.31.4-1.51.71.71.51.0-1.31.20.9-0.9-0.81.10.80.8
Social responses1.01.33.3-1.81.2-1.71.51.70.70.8-0.70.91.0-0.20.3-0.4-0.51.4
Social time0.81.02.1-0.2-0.30.2-0.3-0.2-1.1-1.31.2-1.1-1.31.41.5-1.3-1.3-0.6
Soleus weight0.30.71.4-0.71.1-0.70.70.71.00.8-1.00.90.5-1.1-1.20.80.90.2
Bone: stiffness2.03.210.61.20.00.40.2-0.22.01.1-1.81.70.5-2.3-2.83.33.30.6
Tibialis anterior weight0.10.31.00.8-0.70.8-0.9-0.7-0.20.1-0.10.4-0.3-0.2-0.30.60.51.0
Time to tail flick, vehicle, before self-admin0.40.41.10.1-0.50.2-0.5-0.8-0.8-0.40.7-0.6-0.50.60.9-1.0-1.00.5
Time to tail flick, vehicle, after self-admin0.20.20.7-0.70.6-0.40.40.30.4-0.1-0.2-0.1-0.50.20.1-0.1-0.8-0.8
Time to tail flick, test, before self-admin0.90.92.7-1.61.3-1.51.41.50.60.5-0.50.40.70.20.5-0.5-0.40.5
Time to tail flick, test, after self-admin0.60.62.20.20.40.20.50.51.2-0.1-0.50.2-1.5-0.5-1.01.31.4-0.6
Delta time to tail flick, vehicle, before/after SA0.90.91.6-0.40.8-0.50.81.01.20.9-1.11.00.8-1.1-1.31.20.9-0.2
Delta time to tail flick, test, before/after SA1.41.23.71.7-1.01.5-1.0-1.10.1-0.90.3-0.5-1.9-0.2-0.91.20.9-1.5
Tibia length0.20.63.6-0.90.9-0.60.90.70.7-0.0-0.50.40.0-0.5-0.60.30.3-1.9
Ambulatory time before self-admin0.20.30.9-0.30.1-0.0-0.3-0.2-0.60.00.3-0.30.50.50.8-0.9-0.90.2
Ambulatory time after self-admin0.20.20.5-0.30.4-0.20.30.30.60.5-0.60.6-0.0-0.4-0.50.60.7-0.4
Bone: tissue strength0.60.51.60.8-0.30.8-0.6-0.60.40.0-0.40.5-0.2-0.9-1.21.21.3-0.4
Total heroin consumption0.91.13.1-0.10.7-0.30.30.21.01.1-1.21.20.9-1.7-1.81.21.5-0.4
Bone: trabecular number0.91.42.60.8-0.90.9-0.9-1.2-1.0-1.61.3-1.4-1.51.41.2-0.8-1.3-1.2
Bone: trabecular spacing2.73.56.4-1.91.7-2.11.82.11.62.4-1.92.22.5-1.9-1.30.70.91.8
Bone: trabecular thickness0.20.30.60.4-0.30.4-0.2-0.6-0.4-0.60.5-0.7-0.40.70.5-0.3-0.2-0.8
Bone: trabecular tissue density0.70.93.21.8-1.21.6-1.3-1.4-0.3-0.50.5-0.4-0.40.1-0.30.71.3-0.5
Water consumed over 24 hours2.22.75.2-1.71.6-2.12.31.92.11.7-1.71.61.6-1.3-1.01.21.20.9
Number of responses in last shaping day0.10.10.4-0.2-0.1-0.40.40.30.30.3-0.10.1-0.30.10.20.0-0.00.6