Hub : Genes

Cdk12

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Cdk12 0.14 0.07 0.0e+00 0.2 0.19 0.21 0.18 1.6e-21 1.6e-20 1.2e-22 4.6e-20
2 Adipose alternative polyA XM_039085161.1 0.02 0.01 3.6e-03 0.01 0.01 0 0.01 1.1e-02 6.9e-03 8.6e-02 2.1e-02
3 Adipose mRNA stability Cdk12 0.05 0.03 3.0e-08 0.05 0.06 0.06 0.06 2.1e-06 1.2e-07 6.5e-07 8.9e-07
4 Adipose isoform ratio XM_039085161.1 0.02 0.01 3.2e-03 0.02 0.02 -0 0.01 6.6e-03 4.2e-03 5.2e-01 1.4e-02
5 IL gene expression Cdk12 0.19 0.18 5.9e-03 0.08 0.03 0.07 0.07 6.5e-03 7.3e-02 9.3e-03 8.7e-03
6 Eye gene expression Cdk12 0.5 0.22 9.0e-03 0.04 0 0.03 0.04 8.7e-02 2.9e-01 1.0e-01 9.4e-02
7 NAcc intron excision ratio chr10_83243617_83244645 0.02 0.02 6.2e-03 0.02 0.01 0.01 0.01 3.7e-03 1.8e-02 4.8e-02 1.0e-02
8 RMTg gene expression Cdk12 0.19 0.15 5.0e-03 0.07 0.06 0.06 0.07 5.6e-03 1.1e-02 1.1e-02 6.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density2.23.64.22.02.0-2.12.02.01.7-1.71.7
Area under the delay curve0.70.81.20.50.8-0.90.90.71.0-1.11.1
BMI with tail1.96.28.7-2.9-2.62.5-2.5-2.3-2.92.1-2.1
BMI without tail0.10.20.3-0.5-0.40.4-0.4-0.10.10.5-0.5
Body weight6.025.028.8-5.4-5.35.2-5.3-4.5-4.84.7-4.7
Weight adjusted by age0.40.51.8-0.6-0.50.5-0.4-0.7-1.30.5-0.5
Bone surface0.00.00.1-0.1-0.10.0-0.10.3-0.20.3-0.3
Bone volume0.10.10.30.30.3-0.40.40.6-0.1-0.10.1
Breakpoint value in progressive ratio session0.60.71.2-0.5-1.01.1-1.1-0.2-0.70.9-0.9
Number of licking bursts0.30.40.60.40.7-0.70.70.4-0.4-0.70.7
Context. condit. distance diff. score0.60.72.2-0.9-0.80.8-0.8-1.5-0.60.6-0.6
Locomotion velocity, session 10.70.81.2-0.9-0.90.9-0.9-0.4-0.61.1-1.1
Locomotion distance, session 13.64.75.3-2.3-2.32.2-2.3-1.3-2.22.3-2.3
Locomotion velocity, session 20.50.51.0-0.6-0.80.8-0.8-0.2-0.11.0-1.0
Locomotion distance, session 20.91.21.9-1.0-1.11.1-1.10.3-1.11.4-1.4
Locomotion velocity, session 30.10.10.50.0-0.30.3-0.4-0.10.70.4-0.4
Locomotion distance, session 30.50.50.8-0.6-0.70.7-0.8-0.6-0.30.9-0.9
Stereotopy head waving bouts, day 33.64.34.62.12.1-2.12.11.72.0-2.12.1
Stereotopy head waving duration, day 30.40.50.80.60.7-0.70.70.40.5-0.90.9
Locomotion velocity, session 71.11.22.7-1.2-1.11.0-1.0-1.0-1.60.7-0.7
Locomotion distance, session 70.20.31.1-0.7-0.50.5-0.4-0.2-1.00.1-0.1
Stereotopy head waving bouts, day 70.70.81.20.91.0-1.11.10.50.6-0.90.9
Stereotopy head waving duration, day 70.20.20.40.60.6-0.60.60.20.5-0.40.4
Locomotion velocity, session 87.58.910.2-3.2-3.13.1-3.0-3.0-2.82.9-2.9
Locomotion distance, session 81.62.42.6-1.6-1.61.6-1.6-1.2-1.51.6-1.6
Degree of sensitization distance0.50.51.3-0.9-0.60.7-0.6-0.6-1.10.3-0.3
Degree of sensitization stereotypy1.21.31.81.11.3-1.41.30.70.5-1.31.3
Conditioned locomotion0.20.30.60.40.4-0.40.40.70.7-0.60.6
Cocaine response after cond. corrected1.51.72.50.91.5-1.61.61.4-0.1-1.31.3
Cocaine response after cond. not corrected2.42.73.91.21.9-1.92.01.4-0.2-1.81.8
Cocaine response before conditioning0.60.81.60.70.9-0.91.00.10.2-1.21.2
Saline control response0.30.41.4-0.20.4-0.40.4-0.1-1.2-0.90.9
Bone: connectivity density3.04.85.42.32.3-2.32.22.32.2-2.02.0
Bone: cortical apparent density6.58.610.83.33.0-3.03.03.03.0-2.62.6
Bone: cortical area0.10.20.30.40.5-0.50.60.10.0-0.40.4
Bone: cortical porosity0.50.50.90.40.7-0.80.80.6-0.1-1.01.0
Bone: cortical porosity0.60.61.30.30.8-0.80.80.4-0.5-1.21.2
Bone: cortical thickness1.32.23.01.61.7-1.71.71.11.1-1.31.3
Bone: cortical thickness5.66.57.82.82.6-2.62.62.32.5-2.52.5
Bone: cortical tissue density6.68.710.73.33.0-2.93.03.03.1-2.62.6
Condit. Reinf. active minus inactive responses0.70.81.61.00.8-0.80.81.01.2-0.70.7
Condit. Reinf. active-inactive response ratio1.11.22.61.21.0-0.90.90.91.6-1.01.0
Condit. Reinf. active responses0.81.01.41.21.0-1.01.00.91.1-0.80.8
Condit. Reinf. inactive responses0.30.30.60.50.7-0.70.80.2-0.1-0.70.7
Incentive salience index mean1.72.12.71.61.4-1.41.41.61.6-1.21.2
Condit. Reinf. lever presses1.01.42.11.21.2-1.21.21.50.7-1.11.1
Condit. Reinf. active minus inactive responses0.60.81.21.10.9-0.90.90.90.7-0.80.8
Condit. Reinf. active-inactive response ratio0.40.40.80.80.6-0.60.60.90.6-0.40.4
Condit. Reinf. active responses1.11.52.01.41.2-1.21.21.40.8-1.31.3
Condit. Reinf. inactive responses2.12.63.61.61.6-1.61.61.70.9-1.91.9
Condit. Reinf. lever presses0.00.10.20.40.2-0.20.20.20.4-0.20.2
Condit. Reinf. lever reinforcers received1.11.62.21.51.2-1.21.21.51.0-1.21.2
Conditioned reinforcement - actives1.11.12.10.91.1-1.01.10.50.3-1.41.4
Conditioned reinforcement - inactives1.72.03.21.61.2-1.21.21.51.8-1.31.3
Conditioned locomotion0.81.01.60.81.1-1.11.10.6-0.2-1.31.3
Patch foraging indifference point 0 sec2.03.25.31.81.7-1.61.62.02.3-1.51.5
Patch foraging indifference point AUC0.00.00.1-0.3-0.10.1-0.1-0.1-0.20.3-0.3
Delay disc. indifference point, 0s delay1.41.51.91.31.2-1.21.21.41.1-1.21.2
Delay disc. indifference point, 16s delay0.90.92.00.80.9-0.90.90.81.4-0.90.9
Delay disc. indifference point, 2s delay1.82.02.91.11.5-1.61.61.30.3-1.71.7
Delay disc. indifference point, 24s delay0.10.10.5-0.10.3-0.30.30.10.7-0.30.3
Delay disc. indifference point, 4s delay0.60.60.70.80.8-0.80.80.80.6-0.60.6
Delay disc. indifference point, 8s delay0.70.71.30.30.7-0.70.70.51.1-1.11.1
Indifference point function ln k0.00.00.30.10.1-0.10.10.00.6-0.10.1
Indifference point function log k0.00.00.30.10.1-0.10.10.00.6-0.10.1
Patch foraging total patch changes 0 sec1.42.34.31.51.4-1.41.31.82.1-1.11.1
Patch foraging total patch changes 12 sec5.06.57.92.62.6-2.62.62.82.4-2.42.4
Patch foraging total patch changes 18 sec0.50.60.90.80.9-0.90.90.90.8-0.50.5
Patch foraging total patch changes 24 sec1.92.33.01.51.7-1.71.71.61.2-1.31.3
Patch foraging total patch changes 6 sec2.13.15.01.91.7-1.71.72.22.0-1.31.3
Patch foraging time to switch 0 sec0.10.10.20.40.3-0.30.30.30.2-0.30.3
Patch foraging water rate 0 sec0.00.10.3-0.0-0.10.1-0.10.30.50.2-0.2
Patch foraging water rate 12 sec0.20.40.6-0.3-0.60.6-0.6-0.6-0.40.8-0.8
Patch foraging water rate 18 sec0.40.50.80.70.7-0.80.70.60.3-0.90.9
Patch foraging water rate 24 sec0.40.61.00.80.6-0.70.60.81.0-0.80.8
Patch foraging water rate 6 sec1.11.62.61.31.2-1.21.21.61.4-1.01.0
Seeking ratio, delayed vs. immediate footshock0.10.10.50.60.2-0.10.20.70.40.0-0.0
Distance traveled before self-admin0.10.10.3-0.3-0.50.5-0.5-0.1-0.30.1-0.1
Distance traveled after self-admin1.51.72.3-1.4-1.51.5-1.5-1.2-0.91.1-1.1
Extensor digitorum longus weight8.834.738.4-6.2-6.06.0-5.9-6.2-5.25.8-5.8
Bone: elastic displacement0.00.00.00.10.1-0.10.1-0.00.0-0.10.1
Bone: elastic work0.00.00.10.10.0-0.10.00.2-0.30.1-0.1
Bone: endosteal estimation2.34.96.4-2.5-2.42.3-2.3-2.0-2.32.0-2.0
Bone: endosteal perimeter1.73.54.2-2.0-2.02.0-2.0-1.7-1.31.9-1.9
Epididymis fat weight0.20.60.8-0.8-0.90.9-0.9-0.5-0.90.5-0.5
Delta time in closed arm before/after self-admin4.03.94.6-2.1-2.02.0-2.0-2.0-2.11.8-1.8
Delta time in open arm before/after self-admin0.00.00.10.10.2-0.20.20.00.0-0.20.2
Diff in mean of infusions in LGA sessions0.30.30.7-0.5-0.70.7-0.7-0.6-0.8-0.10.1
Delay discount exponential model param0.40.40.6-0.3-0.60.6-0.6-0.4-0.80.8-0.8
Extinction: sum of active levers before priming1.11.12.0-1.4-1.11.1-1.1-1.4-1.10.5-0.5
Active lever presses in extinction session 60.60.62.30.70.5-0.60.61.50.2-0.60.6
Bone: final force0.91.42.10.81.3-1.31.31.0-0.1-1.41.4
Bone: final moment0.71.11.70.71.1-1.21.20.8-0.3-1.31.3
Food consumed during 24 hour testing period1.01.21.7-1.1-1.11.0-1.1-1.0-0.91.3-1.3
Glucose0.50.71.00.40.9-0.90.90.9-0.4-1.01.0
Heart weight3.24.55.8-2.3-2.32.3-2.3-1.8-2.41.8-1.8
Delay discount hyperbolic model param0.60.60.9-0.5-0.80.8-0.8-0.6-0.81.0-1.0
Intermittent access intake day 1-15 change0.30.30.70.60.3-0.40.30.50.8-0.50.5
Intermittent access intake escalation0.20.20.60.50.2-0.20.20.50.7-0.30.3
Intermittent access intake escalation 20.10.10.1-0.1-0.30.3-0.3-0.00.30.3-0.3
Intermitt. access day 1 inactive lever presses1.71.84.31.30.9-1.00.91.82.1-1.11.1
Intermitt. access day 15 inactive lever presses3.74.16.02.31.9-2.01.92.42.4-1.61.6
Intermitt. access escalation Index1.51.33.9-1.3-0.90.9-0.9-2.0-0.90.9-0.9
Intermittent access day 1 total infusions0.10.10.20.40.4-0.30.40.4-0.0-0.40.4
Intermittent access day 15 total infusions0.30.40.60.70.5-0.50.50.70.7-0.60.6
Intermittent access terminal intake (last 3 days)0.50.50.80.80.6-0.60.60.80.9-0.70.7
Intermittent access total infusions0.10.10.10.40.1-0.10.10.30.2-0.30.3
Intermittent access day 1 locomotion0.30.30.60.50.6-0.60.60.80.0-0.60.6
Intermittent access day 15 total locomotion0.50.50.60.70.7-0.70.80.70.1-0.80.8
Intermittent access total locomotion0.70.81.11.00.9-0.90.91.00.6-0.90.9
Intermittent access standard deviation0.91.03.01.30.6-0.60.61.31.7-0.50.5
Left kidney weight1.85.06.6-1.9-2.52.4-2.5-2.0-1.02.6-2.6
Right kidney weight0.41.11.4-0.8-1.11.1-1.1-1.0-0.81.2-1.2
Cocaine induced anxiety2.32.63.0-1.7-1.71.6-1.7-1.7-1.31.6-1.6
Post-drug Anxiety0.10.10.5-0.4-0.20.2-0.2-0.5-0.70.1-0.1
Baseline Anxiety2.62.83.51.61.9-1.81.91.40.9-1.91.9
Tail length0.72.13.7-1.1-1.61.6-1.6-0.8-0.31.9-1.9
Length with tail4.014.817.6-3.7-4.24.2-4.2-3.2-2.94.1-4.1
Length without tail4.610.111.6-3.3-3.43.4-3.4-2.8-3.32.9-2.9
Times rat made contact with spout0.80.91.41.11.1-1.21.10.90.7-0.70.7
Lifetime Intake0.10.10.10.40.1-0.10.10.30.4-0.30.3
Liver weight, left0.00.10.1-0.1-0.30.3-0.3-0.0-0.20.3-0.3
Liver weight, right0.20.30.80.70.3-0.30.30.80.9-0.20.2
Locomotor activity0.40.70.90.70.9-1.01.00.6-0.0-1.01.0
Locomotor testing distance2.74.56.62.02.2-2.22.21.61.4-2.62.6
Locomotor testing rearing6.610.212.73.43.1-3.13.13.13.6-3.13.1
Locomotion in novel chamber5.16.29.43.02.8-2.72.83.11.4-1.91.9
Locomotion in novel chamber post-restriction0.60.71.30.80.9-1.01.01.10.4-0.70.7
Fecal boli incidents, locomotor time 10.30.30.8-0.6-0.50.4-0.5-0.2-0.90.6-0.6
Change in fecal boli incidents, locomotor task0.10.10.3-0.00.2-0.20.30.1-0.5-0.60.6
Time >=10cm from walls, locomotor time 10.60.60.80.70.9-0.90.90.60.4-0.90.9
Bouts of movement, locomotor time 10.50.61.1-0.9-0.90.8-0.9-1.1-0.30.4-0.4
Total resting periods, locomotor time 11.01.11.9-1.3-1.11.1-1.1-1.4-0.90.6-0.6
Rest time, locomotor task time 10.00.00.2-0.0-0.0-0.0-0.0-0.00.50.0-0.0
Distance moved, locomotor task time 10.20.20.30.40.5-0.50.50.5-0.1-0.60.6
Vertical activity count, locomotor time 10.30.31.9-0.4-0.20.2-0.2-0.1-1.4-0.10.1
Time >=10cm from walls, locomotor time 21.61.72.31.31.5-1.41.51.3-0.1-1.41.4
Bouts of movement, locomotor time 20.30.31.20.50.3-0.20.20.31.1-0.60.6
Total resting periods, locomotor time 20.20.21.00.30.0-0.0-0.00.11.0-0.40.4
Rest time, locomotor task time 21.01.11.5-1.1-1.21.2-1.2-0.9-0.90.9-0.9
Distance moved, locomotor task time 20.00.10.2-0.10.1-0.10.10.3-0.50.1-0.1
Vertical activity count, locomotor time 20.10.20.9-0.4-0.20.2-0.2-0.2-1.00.1-0.1
Light reinforcement 12.44.46.12.22.0-2.02.02.22.5-2.02.0
Light reinforcement 20.60.81.10.70.9-1.00.91.00.4-1.01.0
Bone: marrow area2.14.65.9-2.4-2.32.2-2.2-1.9-2.21.9-1.9
Bone: maximum diameter0.00.00.00.10.1-0.10.10.10.10.0-0.0
Bone: maximum force0.10.10.6-0.20.2-0.20.2-0.0-0.8-0.30.3
Bone: maximum moment0.10.10.8-0.40.0-0.10.1-0.2-0.9-0.20.2
Mean time between licks in bursts1.41.92.4-1.4-1.51.4-1.4-1.6-0.91.4-1.4
Mean num. licks in bursts0.10.10.60.40.1-0.20.10.30.8-0.00.0
Cd content in liver0.10.10.20.30.3-0.30.30.30.4-0.30.3
Co content in liver1.01.21.7-0.8-1.21.2-1.2-1.0-0.41.3-1.3
Cu content in liver0.50.61.1-0.3-0.80.8-0.80.10.51.1-1.1
Fe content in liver1.41.71.9-1.4-1.41.3-1.3-1.1-1.31.4-1.4
K content in liver0.80.82.01.00.8-0.80.71.41.1-0.30.3
Mg content in liver1.01.03.41.10.8-0.80.81.01.9-0.30.3
Mn content in liver1.51.74.61.51.1-1.11.01.62.2-0.60.6
Na content in liver0.20.20.30.30.5-0.50.50.6-0.2-0.40.4
Rb content in liver1.51.92.91.41.3-1.31.31.71.5-1.21.2
Se content in liver4.04.99.42.62.0-2.02.02.53.1-1.51.5
Sr content in liver0.10.10.30.2-0.20.2-0.20.10.50.4-0.4
Zn content in liver2.52.74.41.91.5-1.51.51.62.1-1.51.5
Bone: minimum diameter0.51.01.4-1.1-1.01.0-1.0-1.0-1.20.8-0.8
Time in familiar zone, hab. session 10.50.40.80.30.6-0.60.60.7-0.3-0.90.9
Time in novel zone, hab. session 10.90.91.91.00.9-0.90.90.71.4-0.70.7
Total zone transitions, hab. session 12.13.03.7-1.6-1.81.8-1.8-1.6-1.31.9-1.9
Total locomotion distance, hab. session 10.00.00.1-0.0-0.20.2-0.2-0.3-0.10.2-0.2
Locomotion velocity, hab. session 10.50.71.0-0.7-0.90.9-0.9-1.0-0.60.9-0.9
Time in familiar zone, hab. session 20.50.50.70.60.6-0.70.70.80.4-0.80.8
Time in novel zone, hab. session 20.20.20.60.50.3-0.30.30.30.8-0.20.2
Total zone transitions, hab. session 20.81.01.9-1.2-1.01.0-1.0-0.6-1.40.9-0.9
Total locomotion distance, hab. session 20.30.31.3-0.6-0.50.4-0.5-0.5-1.20.2-0.2
Locomotion velocity, hab. session 20.50.61.8-0.9-0.70.7-0.7-0.7-1.40.4-0.4
Novel to familiar place preference ratio1.21.32.0-1.0-1.11.2-1.2-1.4-0.31.2-1.2
Novelty place preference0.80.81.8-0.8-0.90.9-0.9-1.3-0.10.9-0.9
Time in novel zone, NPP test0.20.20.9-0.3-0.40.4-0.4-0.90.20.4-0.4
Total zone transitions, NPP test0.50.82.2-1.0-0.80.8-0.8-0.3-1.50.7-0.7
Total locomotion distance, NPP test0.10.10.5-0.2-0.0-0.00.00.2-0.70.0-0.0
Locomotion velocity, NPP test0.40.51.3-0.8-0.70.6-0.7-0.4-1.20.7-0.7
Intraocular pressure1.82.54.3-1.7-1.51.5-1.5-2.1-1.90.9-0.9
Delta distance traveled before/after self-admin1.21.31.7-1.2-1.21.1-1.2-1.3-1.01.0-1.0
Delta ambulatory time before/after self-admin0.50.61.2-1.1-0.70.7-0.7-1.1-0.70.4-0.4
Parametrial fat weight0.81.62.21.51.0-1.11.01.41.4-1.41.4
Pavlov. Cond. lever latency2.73.44.2-1.8-1.92.0-1.9-2.0-0.91.9-1.9
Pavlov. Cond. magazine entry latency10.012.914.43.83.8-3.83.83.52.8-3.63.6
Pavlov. Cond. change in total contacts9.09.611.83.43.2-3.23.23.03.2-2.82.8
Pavlov. Cond. index score8.210.411.83.33.4-3.43.43.32.2-3.33.3
Pavlov. Cond. latency score6.27.99.22.93.0-3.03.02.91.7-2.92.9
Pavlov. Cond. lever contacts2.22.63.21.61.7-1.81.81.70.7-1.71.7
Pavlov. Cond. magazine entry number12.815.917.9-4.2-4.24.2-4.2-3.9-3.23.9-3.9
Pavlov. Cond. intertrial magazine entries1.41.72.0-1.3-1.41.4-1.4-1.3-0.71.4-1.4
Pavlov. Cond. lever-magazine prob. diff.9.411.713.23.53.6-3.63.63.42.5-3.53.5
Pavlov. Cond. response bias9.611.612.93.63.6-3.63.63.32.8-3.43.4
Pavlov. Cond. lever latency0.20.20.4-0.6-0.50.6-0.6-0.4-0.30.4-0.4
Pavlov. Cond. magazine entry latency0.20.20.9-0.3-0.20.2-0.2-0.5-0.90.4-0.4
Pavlov. Cond. change in total contacts0.50.71.11.00.9-0.90.91.00.8-0.70.7
Pavlov. Cond. index score0.10.10.20.40.5-0.50.50.3-0.2-0.30.3
Pavlov. Cond. latency score0.10.10.10.20.3-0.30.30.1-0.3-0.20.2
Pavlov. Cond. lever contacts0.60.81.11.01.0-1.01.00.80.3-0.90.9
Pavlov. Cond. magazine entry number0.10.10.3-0.1-0.30.3-0.3-0.00.50.2-0.2
Pavlov. Cond. intertrial magazine entries1.31.72.5-1.1-1.41.4-1.4-1.6-0.31.4-1.4
Pavlov. Cond. lever-magazine prob. diff.0.00.10.10.20.3-0.30.30.1-0.3-0.10.1
Pavlov. Cond. response bias0.81.01.31.11.1-1.21.21.00.4-0.90.9
Time in closed arm before self-admin1.82.05.11.41.3-1.31.21.22.3-1.21.2
Time in closed arm after self-admin0.50.50.7-0.5-0.70.7-0.8-0.80.50.8-0.8
Time in open arm before self-admin3.33.56.0-1.7-1.91.9-1.9-1.4-2.51.8-1.8
Time in open arm after self-admin0.70.71.8-0.8-0.80.9-0.8-0.6-1.30.7-0.7
Bone: periosteal estimation0.30.51.0-0.9-0.70.7-0.7-0.7-1.00.6-0.6
Bone: periosteal perimeter0.81.31.6-1.3-1.21.1-1.1-1.2-1.21.1-1.1
Bone: post-yield work1.21.72.2-1.5-1.31.3-1.3-1.5-1.51.0-1.0
Progressive ratio test 1 active lever presses1.01.11.41.01.2-1.21.20.70.8-1.11.1
Progressive ratio test 1 breakpoint1.01.01.30.91.1-1.11.10.60.7-1.11.1
Progressive ratio test 1 inactive lever presses1.41.63.51.31.1-1.11.01.31.9-1.11.1
Progressive ratio test 2 active lever presses1.21.31.81.31.2-1.11.21.01.0-1.11.1
Progressive ratio test 2 breakpoint0.91.11.41.21.1-1.11.10.80.8-1.01.0
Progressive ratio test 2 inactive lever presses0.20.30.70.70.3-0.30.30.80.7-0.10.1
Incentive Sensitization - Responses1.21.21.81.41.2-1.11.11.20.9-0.90.9
Incentive Sensitization - Breakpoint1.11.21.81.31.1-1.11.11.20.9-0.80.8
Sum of active levers in priming session hrs 5-60.40.40.70.50.6-0.60.60.80.2-0.80.8
Progressive ratio0.10.10.70.10.1-0.10.10.8-0.1-0.00.0
Food seeking constrained by brief footshock0.20.30.80.40.5-0.50.50.40.9-0.40.4
Seeking ratio, punishment vs. effort0.20.20.40.30.4-0.40.4-0.60.6-0.40.4
Retroperitoneal fat weight0.10.20.4-0.5-0.60.5-0.6-0.1-0.20.3-0.3
Reaction time number correct1.01.53.7-1.1-1.11.1-1.1-1.0-1.91.1-1.1
Reaction time mean minus median0.20.30.8-0.5-0.40.3-0.3-0.9-0.90.3-0.3
Reaction time mean minus median AUC0.10.20.30.10.4-0.40.4-0.3-0.5-0.50.5
Reaction time num false alarms0.60.81.20.70.9-1.01.01.00.1-1.11.1
Reaction time num false alarms AUC0.40.61.00.60.8-0.80.80.7-0.1-1.01.0
Reaction time trials correct on left1.01.53.7-1.1-1.11.1-1.1-1.0-1.91.1-1.1
Reaction time trials on left1.01.43.6-1.1-1.11.1-1.0-1.0-1.91.0-1.0
Reaction time mean0.10.20.60.60.3-0.20.2-0.10.80.2-0.2
Reaction time mean AUC0.10.10.60.50.2-0.10.1-0.10.80.3-0.3
Median of all reaction times0.60.82.31.20.8-0.80.80.51.5-0.20.2
Reaction time omissions0.71.01.41.21.0-1.11.01.10.8-0.70.7
Reaction time false alarm rate1.11.51.91.01.2-1.31.31.20.9-1.41.4
Reaction time premature initiation rate0.30.40.90.60.6-0.60.60.30.0-1.01.0
Reaction time premature initiations0.20.21.3-0.2-0.30.3-0.2-0.5-1.1-0.10.1
Std. dev. reaction times0.00.00.20.10.1-0.10.1-0.4-0.30.0-0.0
Reaction time trials completed1.01.43.6-1.1-1.11.1-1.0-1.0-1.91.0-1.0
Reaction time trials AUC0.81.23.3-1.0-0.91.0-0.9-1.0-1.81.0-1.0
Run reversals in cocaine runway, females2.52.43.6-1.5-1.61.7-1.6-1.9-1.41.3-1.3
Run reversals in cocaine runway, males0.60.60.90.80.8-0.80.80.90.8-0.70.7
Latency to leave start box in cocaine runway2.52.73.5-1.5-1.71.8-1.8-1.0-1.41.9-1.9
Latency to leave start box in cocaine runway, F2.52.73.3-1.5-1.71.7-1.7-1.2-1.71.8-1.8
Latency to leave start box in cocaine runway, M0.30.31.10.3-0.30.2-0.30.81.00.6-0.6
Std. dev. time between licks in bursts0.20.30.5-0.4-0.50.5-0.5-0.5-0.20.7-0.7
Total sessions with >9 infusions0.91.01.70.91.0-1.00.90.91.3-1.01.0
Short access day 1 total inactive lever presses1.92.13.01.51.3-1.31.31.71.4-1.51.5
Short access day 10 total inactive lever presses0.40.40.7-0.5-0.80.8-0.8-0.20.00.8-0.8
Short access day 1 total infusions0.60.61.90.80.5-0.50.41.01.4-0.60.6
Short access day 10 total infusions0.20.20.30.60.5-0.50.50.50.3-0.50.5
Short access total infusions0.10.10.40.40.1-0.10.10.40.6-0.20.2
Short access day 1 locomotion3.43.76.82.01.8-1.81.72.12.6-1.51.5
Short access day 10 total locomotion1.82.02.31.31.5-1.51.51.51.2-1.51.5
Short access total locomotion0.60.60.90.70.7-0.70.70.90.9-0.80.8
One hour access (0.3 mA shock)0.00.10.20.10.1-0.00.1-0.2-0.2-0.40.4
Compulsive drug intake0.10.10.4-0.4-0.20.3-0.3-0.6-0.20.1-0.1
One hour access (shock baseline)0.20.20.50.50.4-0.30.40.50.3-0.70.7
Social response proportion0.10.10.4-0.4-0.10.1-0.1-0.1-0.6-0.10.1
Social responses0.10.10.50.10.2-0.30.30.7-0.0-0.20.2
Social time0.10.21.1-0.4-0.20.2-0.2-0.1-1.0-0.00.0
Soleus weight0.30.81.20.10.9-0.91.00.3-1.1-1.01.0
Bone: stiffness0.00.10.2-0.10.2-0.20.2-0.1-0.4-0.30.3
Tibialis anterior weight1.55.25.6-2.4-2.22.2-2.2-2.3-2.32.3-2.3
Time to tail flick, vehicle, before self-admin0.10.10.20.20.3-0.40.40.1-0.0-0.40.4
Time to tail flick, vehicle, after self-admin0.10.10.10.20.3-0.40.30.4-0.4-0.10.1
Time to tail flick, test, before self-admin1.21.22.1-1.3-1.01.0-1.0-1.4-1.40.6-0.6
Time to tail flick, test, after self-admin0.20.20.70.30.3-0.40.30.9-0.2-0.00.0
Delta time to tail flick, vehicle, before/after SA0.20.20.30.30.5-0.60.50.6-0.1-0.50.5
Delta time to tail flick, test, before/after SA2.52.24.41.71.6-1.61.52.11.1-1.01.0
Tibia length1.44.09.0-2.3-1.71.7-1.7-2.2-3.01.5-1.5
Ambulatory time before self-admin0.30.30.5-0.3-0.70.7-0.7-0.4-0.00.5-0.5
Ambulatory time after self-admin2.73.03.9-1.9-2.01.9-2.0-1.7-0.91.7-1.7
Bone: tissue strength0.70.71.2-0.9-0.70.7-0.7-1.0-1.10.7-0.7
Total heroin consumption0.60.71.51.20.7-0.80.71.20.3-0.50.5
Bone: trabecular number5.07.88.82.92.9-3.02.93.02.3-2.72.7
Bone: trabecular spacing1.41.83.9-1.6-1.31.2-1.2-1.3-2.00.8-0.8
Bone: trabecular thickness0.10.10.20.40.2-0.30.20.10.30.0-0.0
Bone: trabecular tissue density0.10.10.90.40.2-0.10.20.10.9-0.00.0
Water consumed over 24 hours0.10.10.3-0.2-0.10.1-0.1-0.4-0.60.1-0.1
Number of responses in last shaping day0.30.31.00.60.1-0.10.10.91.00.3-0.3