Cdca4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Cdca4	0.08	0.06	1.4e-05	0.04	0.04	0.03	0.04	3.3e-05	2.0e-05	1.2e-04	4.6e-05
2	NAcc	gene expression	Cdca4	0.02	0.02	3.4e-04	0.02	0.02	0.03	0.02	1.1e-04	2.4e-04	9.4e-05	1.3e-04
3	Brain	mRNA stability	Cdca4	0.05	0.04	9.8e-06	0.06	0.01	0.05	0.06	2.8e-06	2.1e-02	8.4e-06	2.6e-06
4	Adipose	mRNA stability	Cdca4	0.03	0.03	1.4e-03	0.02	0.02	0.01	0.02	5.7e-03	2.4e-03	5.0e-02	6.0e-03
5	NAcc	mRNA stability	Cdca4	0.01	0.01	3.8e-03	0.02	0.01	0.01	0.01	7.8e-04	3.4e-03	5.8e-03	3.5e-03
6	PL	mRNA stability	Cdca4	0.04	0.04	3.8e-04	0.03	0.03	0.03	0.03	5.8e-04	1.8e-04	3.7e-04	4.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.1	0.1	0.4	-0.4	-0.2	0.6	0.2	0.2	0.1
Area under the delay curve	1.1	1.2	2.9	1.7	1.2	-1.1	-1.0	-0.7	-0.6
BMI with tail	2.5	8.7	10.8	2.4	2.7	-3.1	-3.2	-2.9	-3.3
BMI without tail	1.6	4.7	5.8	2.0	2.0	-2.3	-2.4	-1.9	-2.4
Body weight	1.2	5.1	6.7	-2.6	-2.6	2.2	2.0	2.3	1.7
Weight adjusted by age	0.3	0.4	0.9	-0.5	-0.5	0.5	0.7	0.9	0.7
Bone surface	0.1	0.3	0.6	0.8	0.7	-0.4	-0.4	-0.2	-0.2
Bone volume	0.1	0.1	0.4	0.7	0.5	-0.3	-0.2	-0.2	-0.1
Breakpoint value in progressive ratio session	0.4	0.5	1.5	-1.2	-0.7	0.8	0.3	0.2	-0.0
Number of licking bursts	0.7	1.2	2.4	1.6	1.3	-1.3	-0.9	-0.8	-0.5
Context. condit. distance diff. score	3.5	4.2	4.7	-1.7	-2.1	1.9	2.2	2.1	2.2
Locomotion velocity, session 1	0.1	0.1	0.2	-0.3	-0.2	0.4	0.4	0.5	0.4
Locomotion distance, session 1	0.2	0.3	0.7	0.2	0.6	-0.2	-0.7	-0.5	-0.8
Locomotion velocity, session 2	0.3	0.3	0.7	0.9	0.6	-0.6	-0.4	-0.4	-0.1
Locomotion distance, session 2	0.6	0.9	1.2	1.1	1.0	-1.1	-0.8	-0.8	-0.6
Locomotion velocity, session 3	0.1	0.1	0.3	0.1	0.6	-0.0	-0.2	-0.2	-0.2
Locomotion distance, session 3	0.1	0.1	0.3	0.4	0.5	-0.2	-0.1	-0.3	-0.0
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	-0.2	-0.1	0.2	0.2	0.1	0.2
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.2	-0.3	0.3	0.4	0.4	0.5
Locomotion velocity, session 7	0.1	0.1	0.4	-0.7	-0.3	0.2	-0.1	0.1	-0.4
Locomotion distance, session 7	0.8	1.0	1.2	1.0	1.1	-1.1	-1.0	-0.9	-1.0
Stereotopy head waving bouts, day 7	2.3	2.6	3.7	-1.7	-1.6	1.9	1.5	1.6	1.3
Stereotopy head waving duration, day 7	1.5	1.8	2.8	-1.6	-1.3	1.7	1.2	1.2	0.9
Locomotion velocity, session 8	2.0	2.5	3.3	-1.8	-1.8	1.6	1.5	1.4	1.3
Locomotion distance, session 8	0.3	0.5	0.5	-0.7	-0.7	0.7	0.7	0.7	0.7
Degree of sensitization distance	0.1	0.1	0.3	0.3	0.3	-0.4	-0.5	-0.1	-0.5
Degree of sensitization stereotypy	1.1	1.2	1.7	-1.3	-1.1	1.3	1.0	1.0	0.8
Conditioned locomotion	1.7	2.0	2.2	-1.4	-1.5	1.4	1.4	1.4	1.3
Cocaine response after cond. corrected	0.2	0.2	0.7	-0.6	0.1	0.2	-0.5	-0.3	-0.8
Cocaine response after cond. not corrected	0.8	0.9	2.1	-0.1	0.6	-0.6	-1.1	-1.1	-1.5
Cocaine response before conditioning	2.7	3.3	4.6	1.8	1.6	-2.2	-1.7	-2.0	-1.5
Saline control response	0.1	0.1	0.2	-0.3	-0.1	0.5	0.4	0.3	0.4
Bone: connectivity density	0.5	0.8	1.2	-0.8	-0.8	1.1	0.8	0.9	0.8
Bone: cortical apparent density	4.5	6.2	8.6	-1.7	-2.4	2.2	2.7	2.8	2.9
Bone: cortical area	0.1	0.2	0.3	-0.4	-0.2	0.5	0.5	0.5	0.5
Bone: cortical porosity	0.6	0.6	0.8	-0.6	-0.9	0.7	0.9	0.7	0.9
Bone: cortical porosity	0.1	0.2	0.3	-0.6	-0.5	0.4	0.4	0.0	0.3
Bone: cortical thickness	0.8	1.3	2.2	-1.5	-1.0	1.4	0.9	1.0	0.6
Bone: cortical thickness	0.6	0.7	1.1	-0.5	-0.7	0.8	1.0	1.0	1.1
Bone: cortical tissue density	4.3	5.9	8.3	-1.6	-2.4	2.1	2.7	2.7	2.9
Condit. Reinf. active minus inactive responses	0.2	0.3	0.7	0.2	0.5	-0.2	-0.7	-0.3	-0.8
Condit. Reinf. active-inactive response ratio	1.7	1.8	3.0	0.8	1.3	-1.1	-1.6	-1.3	-1.7
Condit. Reinf. active responses	0.1	0.1	0.4	-0.6	-0.3	0.5	-0.0	0.2	-0.3
Condit. Reinf. inactive responses	2.0	2.5	3.2	-1.7	-1.5	1.8	1.6	1.5	1.4
Incentive salience index mean	0.1	0.2	0.4	-0.6	-0.0	0.3	-0.3	-0.0	-0.7
Condit. Reinf. lever presses	0.2	0.3	1.4	-1.2	-0.6	0.5	0.1	0.1	-0.3
Condit. Reinf. active minus inactive responses	0.4	0.6	1.0	-0.3	-0.7	0.6	0.9	0.9	1.0
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.7	0.0	-0.5	0.3	0.6	0.8	0.8
Condit. Reinf. active responses	0.0	0.0	0.1	0.3	0.0	-0.2	0.1	0.0	0.2
Condit. Reinf. inactive responses	0.4	0.6	0.9	0.6	0.7	-0.7	-0.7	-0.9	-0.7
Condit. Reinf. lever presses	2.3	3.2	4.7	2.2	1.9	-2.0	-1.6	-1.7	-1.3
Condit. Reinf. lever reinforcers received	0.0	0.1	0.2	0.4	0.0	-0.1	0.2	0.2	0.4
Conditioned reinforcement - actives	0.1	0.3	0.5	-0.0	-0.5	0.4	0.6	0.6	0.7
Conditioned reinforcement - inactives	0.4	0.5	0.7	-0.6	-0.8	0.8	0.7	0.8	0.6
Conditioned locomotion	0.1	0.1	0.2	-0.4	-0.4	0.2	-0.1	0.1	-0.2
Patch foraging indifference point 0 sec	5.9	10.9	13.3	-3.5	-3.3	3.7	3.2	3.2	2.9
Patch foraging indifference point AUC	4.3	6.2	10.6	-3.3	-2.7	2.8	2.1	2.2	1.5
Delay disc. indifference point, 0s delay	0.3	0.3	0.4	-0.3	-0.5	0.5	0.5	0.7	0.5
Delay disc. indifference point, 16s delay	1.6	1.8	3.6	1.9	1.5	-1.3	-1.1	-1.0	-0.8
Delay disc. indifference point, 2s delay	3.1	3.5	6.6	2.6	2.0	-2.1	-1.6	-1.4	-1.1
Delay disc. indifference point, 24s delay	1.1	1.2	2.0	1.4	1.2	-1.1	-1.0	-0.9	-0.8
Delay disc. indifference point, 4s delay	0.4	0.4	1.7	1.3	0.4	-0.7	-0.2	-0.0	0.3
Delay disc. indifference point, 8s delay	0.4	0.4	1.1	1.1	0.7	-0.7	-0.6	-0.4	-0.4
Indifference point function ln k	0.4	0.7	1.7	-0.0	-0.7	0.4	1.0	0.8	1.3
Indifference point function log k	0.4	0.7	1.7	-0.0	-0.7	0.4	1.0	0.8	1.3
Patch foraging total patch changes 0 sec	6.7	12.7	15.2	-3.8	-3.6	3.9	3.5	3.4	3.1
Patch foraging total patch changes 12 sec	4.0	5.2	6.9	-2.0	-2.1	2.6	2.3	2.3	2.2
Patch foraging total patch changes 18 sec	2.0	3.0	4.5	-1.9	-1.7	2.1	1.6	1.7	1.4
Patch foraging total patch changes 24 sec	0.9	1.5	2.6	-1.6	-1.3	1.5	1.1	0.9	0.8
Patch foraging total patch changes 6 sec	5.7	8.7	14.2	-3.8	-3.0	3.4	2.6	2.5	2.0
Patch foraging time to switch 0 sec	8.6	17.7	19.1	4.1	4.3	-4.2	-4.2	-4.4	-4.0
Patch foraging water rate 0 sec	13.4	28.3	31.0	-4.9	-5.3	5.3	5.5	5.6	5.3
Patch foraging water rate 12 sec	4.8	10.0	15.3	-1.8	-3.0	2.6	3.5	3.6	3.9
Patch foraging water rate 18 sec	3.3	5.0	7.0	-1.6	-2.3	1.8	2.5	2.4	2.6
Patch foraging water rate 24 sec	2.6	3.6	5.6	-1.2	-2.0	1.4	2.2	2.0	2.4
Patch foraging water rate 6 sec	4.0	5.8	6.8	-2.0	-2.5	2.2	2.6	2.5	2.6
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.4	-0.3	-0.5	0.2	0.6	0.5	0.7
Distance traveled before self-admin	0.5	0.7	0.7	0.8	0.9	-0.9	-0.8	-0.8	-0.8
Distance traveled after self-admin	0.1	0.2	0.4	0.1	-0.2	0.3	0.5	0.5	0.6
Extensor digitorum longus weight	9.0	35.3	37.5	-5.9	-6.1	6.0	6.1	5.9	5.7
Bone: elastic displacement	0.1	0.1	0.4	0.6	-0.0	0.0	0.2	0.3	0.5
Bone: elastic work	0.4	0.6	1.9	1.4	0.8	-0.8	-0.4	-0.3	-0.0
Bone: endosteal estimation	1.4	3.0	6.5	2.5	2.0	-1.9	-1.3	-1.3	-0.7
Bone: endosteal perimeter	0.3	0.6	1.1	0.9	1.0	-0.7	-0.6	-0.7	-0.4
Epididymis fat weight	2.2	7.5	10.1	2.0	2.8	-2.6	-3.1	-2.7	-3.2
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.0	-0.3	-0.3	0.2	0.0	0.2
Delta time in open arm before/after self-admin	1.1	1.0	1.6	-1.2	-1.0	1.2	0.9	1.1	0.6
Diff in mean of infusions in LGA sessions	0.5	0.7	2.1	-1.5	-0.8	0.9	0.5	0.2	0.1
Delay discount exponential model param	1.0	1.1	2.7	-1.6	-1.1	1.1	0.9	0.6	0.6
Extinction: sum of active levers before priming	0.2	0.3	0.6	-0.8	-0.2	0.5	-0.4	-0.1	-0.7
Active lever presses in extinction session 6	1.8	1.8	2.0	-1.1	-1.3	1.4	1.4	1.4	1.4
Bone: final force	0.2	0.3	1.1	1.0	0.7	-0.6	-0.1	-0.2	0.2
Bone: final moment	0.1	0.2	0.6	0.8	0.5	-0.5	0.0	-0.1	0.3
Food consumed during 24 hour testing period	0.7	0.9	1.0	-1.0	-1.0	0.9	0.9	1.0	0.8
Glucose	0.1	0.2	0.4	0.4	0.0	0.3	0.4	0.6	0.6
Heart weight	0.4	0.5	0.8	-0.4	-0.7	0.6	0.8	0.9	0.9
Delay discount hyperbolic model param	1.1	1.2	3.0	-1.7	-1.2	1.1	0.9	0.7	0.6
Intermittent access intake day 1-15 change	1.3	2.7	3.8	1.3	1.4	-1.6	-1.9	-1.7	-1.9
Intermittent access intake escalation	1.4	2.8	3.9	1.3	1.6	-1.5	-1.9	-1.7	-2.0
Intermittent access intake escalation 2	0.8	0.9	1.8	0.6	0.9	-0.7	-1.2	-0.9	-1.3
Intermitt. access day 1 inactive lever presses	0.2	0.9	1.6	-0.9	-0.8	1.3	0.9	1.0	0.8
Intermitt. access day 15 inactive lever presses	1.7	3.4	4.3	-1.6	-1.8	2.0	1.8	2.1	1.7
Intermitt. access escalation Index	0.3	0.5	1.3	-0.2	-0.4	0.6	0.9	0.5	1.1
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.0	0.3	-0.3	-0.4	-0.3	-0.5
Intermittent access day 15 total infusions	1.0	1.5	2.0	1.0	1.2	-1.2	-1.4	-1.1	-1.4
Intermittent access terminal intake (last 3 days)	1.4	1.8	2.4	1.1	1.4	-1.2	-1.5	-1.2	-1.6
Intermittent access total infusions	0.4	0.4	0.7	0.4	0.6	-0.7	-0.8	-0.6	-0.8
Intermittent access day 1 locomotion	0.5	0.7	1.4	0.2	0.7	-0.6	-1.0	-0.9	-1.2
Intermittent access day 15 total locomotion	0.5	0.8	1.3	1.0	0.7	-1.1	-0.9	-1.0	-0.8
Intermittent access total locomotion	0.2	0.2	0.6	0.0	0.3	-0.4	-0.6	-0.5	-0.8
Intermittent access standard deviation	0.3	0.7	2.2	-0.4	0.3	-0.4	-1.0	-0.8	-1.5
Left kidney weight	2.3	10.7	12.9	-3.3	-3.6	3.1	3.4	3.1	3.2
Right kidney weight	1.7	7.6	9.3	-2.7	-3.1	2.4	2.9	2.6	2.8
Cocaine induced anxiety	0.7	1.0	1.3	-0.8	-1.0	0.9	1.1	1.0	1.1
Post-drug Anxiety	1.8	1.9	2.7	-1.0	-1.4	1.2	1.6	1.4	1.6
Baseline Anxiety	0.1	0.1	0.2	0.5	0.3	-0.4	-0.3	-0.3	-0.2
Tail length	5.5	21.3	23.9	-4.2	-4.8	4.6	4.7	4.9	4.5
Length with tail	9.4	41.0	44.3	-6.3	-6.7	6.5	6.4	6.5	6.0
Length without tail	5.5	17.8	20.8	-4.6	-4.4	4.4	4.2	4.0	3.7
Times rat made contact with spout	0.2	0.3	0.6	-0.6	-0.4	0.8	0.4	0.6	0.3
Lifetime Intake	0.4	0.4	0.5	0.7	0.7	-0.7	-0.7	-0.5	-0.7
Liver weight, left	3.4	5.6	6.9	-2.4	-2.6	2.4	2.4	2.2	2.2
Liver weight, right	0.0	0.1	0.3	-0.5	-0.2	0.2	-0.1	-0.2	-0.3
Locomotor activity	0.1	0.2	0.3	-0.3	-0.5	0.2	0.5	0.3	0.5
Locomotor testing distance	0.1	0.1	0.3	-0.1	-0.4	0.2	0.5	0.3	0.6
Locomotor testing rearing	1.9	3.7	4.2	1.7	2.1	-2.0	-2.0	-2.0	-1.9
Locomotion in novel chamber	2.1	2.7	4.6	-0.7	-1.4	1.3	1.9	2.0	2.1
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	0.5	0.3	-0.4	-0.2	-0.3	-0.1
Fecal boli incidents, locomotor time 1	0.4	0.6	1.9	-0.3	0.3	-0.4	-1.0	-0.7	-1.4
Change in fecal boli incidents, locomotor task	0.9	0.9	2.0	-0.4	-0.8	0.5	1.2	0.7	1.4
Time >=10cm from walls, locomotor time 1	1.8	1.9	6.1	-2.5	-1.5	1.5	0.8	0.4	0.1
Bouts of movement, locomotor time 1	1.2	1.4	2.0	1.0	1.3	-0.7	-1.4	-1.1	-1.4
Total resting periods, locomotor time 1	1.4	1.6	2.1	1.2	1.5	-0.9	-1.4	-1.1	-1.4
Rest time, locomotor task time 1	0.5	0.6	1.6	1.3	0.8	-0.7	-0.6	-0.4	-0.3
Distance moved, locomotor task time 1	0.3	0.4	0.7	0.7	0.6	-0.9	-0.6	-0.7	-0.5
Vertical activity count, locomotor time 1	0.0	0.1	0.1	0.2	-0.2	-0.3	0.3	-0.1	0.4
Time >=10cm from walls, locomotor time 2	1.4	2.0	4.4	-2.1	-1.4	1.7	1.2	1.0	0.7
Bouts of movement, locomotor time 2	0.4	0.6	1.3	1.1	0.2	0.0	0.6	0.7	1.1
Total resting periods, locomotor time 2	0.3	0.5	1.5	1.2	0.3	-0.1	0.4	0.6	1.0
Rest time, locomotor task time 2	0.1	0.1	0.6	0.8	0.1	-0.2	-0.1	0.2	0.2
Distance moved, locomotor task time 2	0.3	0.3	0.4	0.3	0.6	-0.6	-0.5	-0.7	-0.6
Vertical activity count, locomotor time 2	0.1	0.1	0.4	-0.6	-0.3	0.3	0.5	0.1	0.3
Light reinforcement 1	0.0	0.0	0.0	-0.2	-0.2	0.0	0.2	-0.2	0.2
Light reinforcement 2	1.1	1.8	2.8	0.6	1.0	-1.3	-1.5	-1.6	-1.7
Bone: marrow area	1.3	2.8	6.3	2.5	1.9	-1.9	-1.2	-1.3	-0.6
Bone: maximum diameter	0.2	0.4	0.6	0.4	0.8	-0.5	-0.6	-0.7	-0.7
Bone: maximum force	0.0	0.1	0.2	0.4	0.3	-0.1	0.0	0.0	0.2
Bone: maximum moment	0.0	0.0	0.1	0.1	0.1	0.0	0.1	0.2	0.2
Mean time between licks in bursts	0.3	0.7	1.0	0.8	0.6	-1.0	-0.8	-0.9	-0.8
Mean num. licks in bursts	1.1	1.8	3.4	-1.8	-1.4	1.6	1.0	1.1	0.6
Cd content in liver	0.1	0.1	0.4	0.6	0.2	-0.3	0.1	0.3	0.4
Co content in liver	0.9	1.1	2.0	-0.5	-0.7	1.0	1.1	1.4	1.2
Cu content in liver	1.5	1.8	2.0	1.2	1.4	-1.4	-1.4	-1.4	-1.3
Fe content in liver	0.7	0.8	1.0	1.0	1.0	-1.0	-0.8	-0.9	-0.7
K content in liver	0.6	0.6	0.9	-0.9	-1.0	0.8	0.7	0.6	0.6
Mg content in liver	0.1	0.1	0.3	-0.1	-0.4	0.2	0.4	0.2	0.5
Mn content in liver	0.0	0.0	0.1	0.1	-0.0	-0.1	0.0	-0.3	0.1
Na content in liver	0.5	0.5	1.0	0.2	0.5	-0.5	-0.8	-1.0	-0.9
Rb content in liver	0.4	0.4	1.1	-0.1	-0.4	0.5	0.8	0.6	1.0
Se content in liver	0.1	0.1	0.2	0.4	0.3	-0.3	-0.3	-0.4	-0.3
Sr content in liver	0.2	0.2	0.7	0.8	0.5	-0.4	-0.0	-0.0	0.3
Zn content in liver	0.3	0.3	0.7	0.2	-0.3	0.4	0.6	0.7	0.9
Bone: minimum diameter	0.4	0.7	1.3	-0.5	-0.6	0.8	1.0	1.0	1.1
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.0	0.1	0.1	-0.0	0.1	-0.0
Time in novel zone, hab. session 1	0.8	0.8	1.2	1.1	0.9	-1.1	-0.8	-1.0	-0.6
Total zone transitions, hab. session 1	0.5	0.7	1.3	1.1	0.8	-0.9	-0.6	-0.8	-0.4
Total locomotion distance, hab. session 1	0.2	0.2	0.7	0.5	-0.2	0.0	0.5	0.3	0.8
Locomotion velocity, hab. session 1	0.5	0.7	1.4	-0.2	-0.7	0.7	1.0	0.7	1.2
Time in familiar zone, hab. session 2	0.4	0.5	1.6	-1.3	-0.6	0.8	0.3	0.3	-0.1
Time in novel zone, hab. session 2	0.9	0.9	2.2	1.5	1.0	-1.0	-0.7	-0.7	-0.4
Total zone transitions, hab. session 2	0.2	0.2	0.6	0.2	0.5	-0.1	-0.6	-0.3	-0.8
Total locomotion distance, hab. session 2	0.3	0.4	0.5	-0.2	-0.5	0.7	0.6	0.7	0.7
Locomotion velocity, hab. session 2	0.4	0.6	0.8	-0.3	-0.6	0.9	0.8	0.9	0.9
Novel to familiar place preference ratio	0.8	0.8	1.2	1.0	1.1	-0.7	-0.9	-0.9	-0.8
Novelty place preference	0.8	0.9	1.5	1.2	1.2	-0.8	-0.9	-0.8	-0.7
Time in novel zone, NPP test	0.3	0.3	0.6	0.7	0.8	-0.4	-0.6	-0.5	-0.5
Total zone transitions, NPP test	0.5	0.7	1.2	-0.9	-0.8	1.1	0.7	0.9	0.6
Total locomotion distance, NPP test	0.4	0.6	0.8	-0.6	-0.8	0.9	0.8	0.8	0.8
Locomotion velocity, NPP test	0.3	0.4	0.6	-0.3	-0.6	0.6	0.6	0.8	0.7
Intraocular pressure	0.2	0.3	1.0	1.0	0.7	-0.4	-0.4	-0.1	-0.1
Delta distance traveled before/after self-admin	0.0	0.1	0.1	-0.0	-0.1	0.2	0.3	0.3	0.3
Delta ambulatory time before/after self-admin	0.5	0.6	1.2	-0.2	-0.6	0.7	0.9	1.0	1.1
Parametrial fat weight	0.1	0.1	0.2	-0.5	-0.4	-0.2	-0.2	-0.4	-0.4
Pavlov. Cond. lever latency	0.2	0.3	0.8	0.3	-0.2	0.2	0.6	0.5	0.9
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	-0.6	-0.1	0.2	-0.3	-0.2	-0.6
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.5	-0.1	0.2	-0.2	-0.1	-0.4
Pavlov. Cond. index score	0.2	0.3	0.9	-0.5	0.1	0.0	-0.6	-0.4	-0.9
Pavlov. Cond. latency score	0.2	0.2	0.7	-0.4	0.1	0.0	-0.5	-0.4	-0.8
Pavlov. Cond. lever contacts	0.5	0.6	1.5	0.0	0.6	-0.5	-1.0	-0.9	-1.2
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	0.6	0.1	-0.2	0.4	0.2	0.7
Pavlov. Cond. intertrial magazine entries	7.8	9.4	10.5	-3.0	-3.1	3.2	3.1	3.1	2.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	-0.5	0.1	0.0	-0.6	-0.4	-0.9
Pavlov. Cond. response bias	0.3	0.3	1.0	-0.8	-0.1	0.2	-0.5	-0.3	-1.0
Pavlov. Cond. lever latency	3.0	4.0	5.6	-2.4	-2.1	2.2	1.9	1.9	1.6
Pavlov. Cond. magazine entry latency	3.4	4.2	5.1	1.9	2.3	-1.9	-2.1	-2.0	-2.0
Pavlov. Cond. change in total contacts	4.9	7.8	9.2	2.9	3.0	-2.9	-2.8	-2.7	-2.5
Pavlov. Cond. index score	4.4	5.9	7.1	2.6	2.7	-2.5	-2.4	-2.3	-2.2
Pavlov. Cond. latency score	4.1	5.5	6.4	2.3	2.5	-2.3	-2.4	-2.3	-2.2
Pavlov. Cond. lever contacts	3.5	4.9	6.3	2.5	2.3	-2.3	-2.1	-2.1	-1.8
Pavlov. Cond. magazine entry number	3.3	4.1	5.6	-2.0	-2.4	1.8	2.0	1.9	1.9
Pavlov. Cond. intertrial magazine entries	4.2	6.3	7.4	-2.1	-2.7	2.3	2.6	2.6	2.6
Pavlov. Cond. lever-magazine prob. diff.	5.1	6.8	8.1	2.7	2.8	-2.6	-2.6	-2.5	-2.3
Pavlov. Cond. response bias	3.5	4.8	6.3	2.5	2.3	-2.3	-2.1	-2.0	-1.8
Time in closed arm before self-admin	6.4	8.2	10.3	3.0	3.2	-2.9	-2.8	-2.8	-2.5
Time in closed arm after self-admin	5.2	5.6	8.8	3.0	2.4	-2.9	-2.0	-2.1	-1.4
Time in open arm before self-admin	4.8	5.2	6.1	-2.1	-2.5	2.3	2.4	2.2	2.3
Time in open arm after self-admin	8.5	9.3	13.7	-3.7	-3.3	3.4	2.8	2.8	2.2
Bone: periosteal estimation	0.3	0.6	1.9	1.4	1.0	-0.8	-0.4	-0.4	-0.0
Bone: periosteal perimeter	0.0	0.1	0.2	0.1	0.4	-0.2	-0.2	-0.3	-0.2
Bone: post-yield work	2.2	3.2	3.7	-1.7	-1.6	1.9	1.9	1.9	1.8
Progressive ratio test 1 active lever presses	0.3	0.4	0.7	0.8	0.7	-0.8	-0.6	-0.5	-0.5
Progressive ratio test 1 breakpoint	0.4	0.5	0.7	0.7	0.8	-0.9	-0.7	-0.5	-0.6
Progressive ratio test 1 inactive lever presses	1.4	2.0	2.6	-1.0	-1.4	1.3	1.5	1.6	1.6
Progressive ratio test 2 active lever presses	0.4	0.5	1.1	1.0	0.6	-1.1	-0.5	-0.6	-0.2
Progressive ratio test 2 breakpoint	0.4	0.5	1.0	1.0	0.6	-1.0	-0.4	-0.5	-0.2
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.5	0.7	-0.0	-0.3	0.3	0.3	0.6
Incentive Sensitization - Responses	0.2	0.3	0.8	0.9	0.5	-0.9	-0.3	-0.5	-0.1
Incentive Sensitization - Breakpoint	0.3	0.3	0.8	0.9	0.5	-0.8	-0.3	-0.5	0.0
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.8	-1.4	-0.9	1.0	0.6	0.6	0.2
Progressive ratio	1.1	1.7	4.9	2.2	1.2	-1.5	-0.8	-0.8	-0.2
Food seeking constrained by brief footshock	0.3	0.3	0.8	0.4	-0.1	0.3	0.5	0.9	0.8
Seeking ratio, punishment vs. effort	0.8	1.2	2.2	-1.5	-0.9	1.4	0.8	1.1	0.5
Retroperitoneal fat weight	0.0	0.2	0.4	0.3	0.1	-0.4	-0.5	-0.2	-0.6
Reaction time number correct	3.0	5.7	6.3	-2.3	-2.4	2.3	2.5	2.4	2.4
Reaction time mean minus median	0.0	0.0	0.0	0.2	0.1	0.0	-0.1	0.0	-0.1
Reaction time mean minus median AUC	0.0	0.0	0.1	0.3	0.1	0.2	0.0	0.1	0.1
Reaction time num false alarms	1.7	2.4	2.9	-1.6	-1.7	1.5	1.5	1.6	1.3
Reaction time num false alarms AUC	1.7	2.6	3.3	-1.6	-1.8	1.5	1.6	1.7	1.5
Reaction time trials correct on left	3.0	5.7	6.3	-2.3	-2.4	2.3	2.5	2.4	2.4
Reaction time trials on left	3.1	5.8	6.5	-2.3	-2.4	2.3	2.5	2.4	2.4
Reaction time mean	1.2	2.0	3.6	1.9	1.4	-1.5	-1.3	-1.1	-1.0
Reaction time mean AUC	0.7	1.1	2.3	1.5	1.1	-1.1	-0.9	-0.8	-0.6
Median of all reaction times	1.3	1.8	3.9	2.0	1.3	-1.5	-1.1	-1.0	-0.7
Reaction time omissions	0.4	0.6	1.4	0.1	-0.6	0.3	0.9	0.8	1.2
Reaction time false alarm rate	0.1	0.2	0.4	-0.4	-0.6	0.3	0.4	0.4	0.3
Reaction time premature initiation rate	0.3	0.4	0.8	-0.2	-0.5	0.8	0.7	0.7	0.9
Reaction time premature initiations	1.9	3.3	3.8	-1.5	-1.7	1.9	1.9	1.8	2.0
Std. dev. reaction times	0.6	1.1	2.5	1.6	1.1	-1.1	-0.9	-0.7	-0.6
Reaction time trials completed	3.1	5.8	6.5	-2.3	-2.4	2.3	2.5	2.4	2.4
Reaction time trials AUC	3.2	6.0	6.7	-2.4	-2.5	2.3	2.6	2.5	2.5
Run reversals in cocaine runway, females	1.4	1.4	2.0	1.4	1.4	-1.1	-1.1	-1.0	-0.9
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.3	0.0	-0.3	0.1	-0.0	0.3
Latency to leave start box in cocaine runway	1.0	1.2	1.8	1.4	1.3	-1.0	-1.0	-0.9	-0.8
Latency to leave start box in cocaine runway, F	0.7	0.8	1.0	0.8	0.9	-0.9	-0.8	-1.0	-0.8
Latency to leave start box in cocaine runway, M	0.5	0.4	1.1	1.0	0.9	-0.4	-0.6	-0.3	-0.4
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.2	-0.1	0.2	0.2	0.1	0.2
Total sessions with >9 infusions	1.0	1.2	2.2	1.5	1.3	-1.3	-0.9	-0.8	-0.6
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.3	0.1	-0.3	0.0	0.2	0.2
Short access day 10 total inactive lever presses	0.1	0.2	0.3	-0.3	-0.5	0.5	0.4	0.5	0.4
Short access day 1 total infusions	0.1	0.2	0.6	0.7	0.4	-0.6	-0.0	0.0	0.2
Short access day 10 total infusions	0.6	0.8	1.0	0.9	1.0	-0.9	-0.9	-0.7	-0.8
Short access total infusions	1.0	1.3	2.3	1.5	1.3	-1.4	-0.9	-0.8	-0.6
Short access day 1 locomotion	0.9	1.1	1.7	1.3	1.0	-1.3	-1.0	-0.9	-0.8
Short access day 10 total locomotion	0.4	0.8	1.8	0.2	0.8	-0.5	-1.1	-0.8	-1.3
Short access total locomotion	0.4	0.5	0.7	0.7	0.7	-0.8	-0.7	-0.6	-0.6
One hour access (0.3 mA shock)	0.2	0.2	0.5	-0.7	-0.5	0.6	0.3	0.4	0.1
Compulsive drug intake	1.2	1.4	3.3	-1.8	-1.3	1.3	0.9	0.9	0.5
One hour access (shock baseline)	0.0	0.1	0.2	0.4	0.2	-0.1	-0.2	0.1	-0.1
Social response proportion	0.5	0.5	1.3	1.1	0.4	-1.2	-0.2	-0.6	0.1
Social responses	0.4	0.5	1.1	1.0	0.8	-0.8	-0.4	-0.4	-0.2
Social time	0.5	0.6	1.7	1.0	-0.2	-0.2	0.7	0.8	1.3
Soleus weight	1.5	4.5	9.7	-3.1	-2.2	2.4	1.7	1.7	1.0
Bone: stiffness	0.6	1.0	1.4	-0.8	-0.8	1.1	1.1	1.1	1.2
Tibialis anterior weight	0.6	2.1	3.0	-1.7	-1.4	1.6	1.3	1.4	1.1
Time to tail flick, vehicle, before self-admin	0.9	1.0	1.4	-0.9	-0.9	1.2	0.9	1.2	0.8
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.1	-0.2	-0.4
Time to tail flick, test, before self-admin	0.6	0.6	1.5	1.2	0.9	-0.8	-0.7	-0.5	-0.4
Time to tail flick, test, after self-admin	1.7	1.7	2.5	-1.6	-1.4	1.4	1.3	1.0	1.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.5	-0.7	-0.4	0.3	0.2	-0.0	-0.0
Delta time to tail flick, test, before/after SA	2.3	2.3	3.1	-1.7	-1.7	1.5	1.5	1.4	1.3
Tibia length	0.1	0.4	0.6	-0.6	-0.8	0.4	0.6	0.6	0.6
Ambulatory time before self-admin	0.6	0.9	1.2	0.6	0.9	-0.9	-1.0	-1.1	-1.1
Ambulatory time after self-admin	0.1	0.1	0.1	0.3	0.3	-0.3	-0.2	-0.3	-0.1
Bone: tissue strength	0.1	0.1	0.2	0.5	0.3	-0.3	-0.2	-0.0	-0.1
Total heroin consumption	4.4	5.1	8.0	-2.8	-2.5	2.4	2.0	2.1	1.5
Bone: trabecular number	0.3	0.5	1.0	-0.7	-0.6	1.0	0.7	0.7	0.6
Bone: trabecular spacing	0.1	0.1	0.3	0.3	0.2	-0.5	-0.3	-0.4	-0.3
Bone: trabecular thickness	0.0	0.0	0.0	-0.2	-0.2	0.1	-0.0	-0.0	-0.1
Bone: trabecular tissue density	0.0	0.1	0.2	0.0	0.1	-0.2	-0.3	-0.3	-0.4
Water consumed over 24 hours	1.1	1.5	2.4	-0.7	-1.1	1.1	1.4	1.3	1.5
Number of responses in last shaping day	0.1	0.1	0.2	0.5	0.4	-0.3	-0.1	-0.1	-0.0