Cdc42ep1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Cdc42ep1	0.04	0.04	4.8e-03	0.01	0.01	0.01	-0	5.2e-02	1.4e-02	1.9e-02	4.8e-01
2	Liver	alternative TSS	NM_001079700.1	0.02	0.02	6.1e-04	0.01	0.01	0.01	0.01	3.4e-02	7.0e-03	1.4e-02	3.6e-02
3	Liver	isoform ratio	XM_017594865.3	0.06	0.04	2.8e-08	0.07	0.06	0.06	0.06	7.4e-08	2.7e-07	1.4e-07	1.5e-07
4	Adipose	gene expression	Cdc42ep1	0.02	0.01	4.7e-03	0.01	0	0	0	2.2e-02	2.0e-01	1.0e-01	1.6e-01
5	Liver	gene expression	Cdc42ep1	0.06	0.04	8.8e-09	0.07	0.06	0.06	0.07	1.1e-08	2.6e-07	3.3e-07	4.3e-08
6	LHb	alternative TSS	XM_017594865.3	0.34	0.17	5.1e-03	0.03	0.04	0.02	0.1	7.0e-02	4.0e-02	9.9e-02	2.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.3	0.5	1.1	-0.2	-0.8	-0.6	1.0	-1.0	-0.1
Area under the delay curve	0.5	0.8	2.9	1.0	0.7	0.3	-0.3	0.3	1.7
BMI with tail	1.8	6.1	11.1	-1.6	-2.5	-3.3	2.8	-2.7	-1.2
BMI without tail	0.5	2.7	4.6	-0.9	-1.5	-2.1	1.6	-1.5	-2.0
Body weight	1.8	8.1	11.9	-2.6	-3.0	-3.5	2.6	-2.5	-2.8
Weight adjusted by age	0.1	0.3	0.8	-0.9	-0.4	0.1	-0.0	0.1	-0.8
Bone surface	0.2	0.4	0.6	0.2	0.6	0.7	-0.7	0.7	0.4
Bone volume	0.0	0.0	0.1	0.3	0.2	0.1	-0.2	0.2	0.0
Breakpoint value in progressive ratio session	0.1	0.3	0.6	0.0	-0.3	-0.8	0.6	-0.6	0.4
Number of licking bursts	0.6	1.9	4.2	1.4	1.4	2.1	-1.3	1.3	0.2
Context. condit. distance diff. score	1.0	1.3	2.5	-1.6	-1.2	-0.8	0.8	-0.7	-1.3
Locomotion velocity, session 1	1.3	1.5	3.8	-0.6	0.7	1.9	-1.4	1.4	-0.3
Locomotion distance, session 1	5.8	7.4	10.5	2.0	2.9	3.2	-3.0	3.0	1.8
Locomotion velocity, session 2	0.3	0.4	1.4	-0.7	0.0	0.3	-0.3	0.3	1.2
Locomotion distance, session 2	4.1	5.7	6.7	1.9	2.6	2.6	-2.4	2.4	2.4
Locomotion velocity, session 3	2.7	3.1	5.5	0.2	1.5	2.3	-2.3	2.3	-0.3
Locomotion distance, session 3	5.0	5.7	8.0	2.2	2.7	2.4	-2.8	2.8	0.2
Stereotopy head waving bouts, day 3	0.8	0.9	1.7	-1.3	-1.1	-0.9	0.9	-0.8	-0.4
Stereotopy head waving duration, day 3	3.1	3.8	8.0	-2.8	-2.4	-1.4	1.7	-1.7	-1.1
Locomotion velocity, session 7	0.5	0.6	2.1	-0.8	-0.7	0.2	0.3	-0.4	-1.4
Locomotion distance, session 7	0.3	0.4	1.9	-0.2	-0.1	0.6	-0.3	0.3	-1.4
Stereotopy head waving bouts, day 7	1.2	1.3	5.0	-2.2	-1.3	-0.2	0.5	-0.5	-0.9
Stereotopy head waving duration, day 7	1.6	2.0	5.6	-2.4	-1.7	-0.8	1.1	-1.1	-0.6
Locomotion velocity, session 8	0.6	0.7	2.5	-1.6	-0.3	0.9	-0.5	0.5	-0.3
Locomotion distance, session 8	0.1	0.2	0.5	-0.7	-0.2	0.5	-0.2	0.2	0.2
Degree of sensitization distance	7.0	7.5	10.5	-2.9	-3.2	-2.4	2.9	-2.9	-1.8
Degree of sensitization stereotypy	0.8	0.9	4.0	-2.0	-0.9	0.4	0.1	-0.1	-0.4
Conditioned locomotion	0.8	0.9	1.4	-1.2	-1.0	-0.9	0.6	-0.6	-1.2
Cocaine response after cond. corrected	0.4	0.6	1.3	-1.1	-0.9	-0.4	0.7	-0.7	0.1
Cocaine response after cond. not corrected	0.5	0.7	1.1	-1.0	-1.0	-0.4	1.1	-1.1	0.4
Cocaine response before conditioning	0.3	0.4	1.0	1.0	0.5	0.7	-0.1	0.1	0.6
Saline control response	0.4	0.5	1.2	0.3	0.7	1.1	-0.8	0.8	-0.2
Bone: connectivity density	0.1	0.1	0.5	-0.3	-0.3	0.2	0.2	-0.2	-0.7
Bone: cortical apparent density	0.9	1.4	2.2	1.4	1.1	1.5	-1.0	1.0	-1.1
Bone: cortical area	0.4	0.7	1.0	-0.9	-1.0	-0.8	0.9	-0.9	-0.4
Bone: cortical porosity	0.8	0.8	1.0	-1.0	-1.0	-0.9	1.0	-1.0	0.6
Bone: cortical porosity	0.7	0.8	2.5	-1.6	-1.0	-0.6	0.7	-0.7	0.3
Bone: cortical thickness	0.2	0.3	1.2	1.1	0.5	-0.1	0.0	-0.0	0.8
Bone: cortical thickness	0.4	0.5	1.3	1.1	0.7	0.4	-0.2	0.2	1.1
Bone: cortical tissue density	0.9	1.5	2.5	1.3	1.1	1.6	-1.0	1.0	-1.1
Condit. Reinf. active minus inactive responses	1.1	1.2	1.6	1.1	1.1	1.3	-1.2	1.2	-0.6
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.5	0.9	1.2	1.6	-1.4	1.5	-0.6
Condit. Reinf. active responses	0.7	0.8	2.3	1.5	0.9	0.7	-0.7	0.6	-0.6
Condit. Reinf. inactive responses	0.3	0.3	1.6	1.2	0.2	-0.3	0.3	-0.4	-0.3
Incentive salience index mean	0.7	0.9	1.4	1.2	0.9	0.7	-0.8	0.8	-1.2
Condit. Reinf. lever presses	0.4	0.6	2.3	1.0	0.2	-0.1	-0.1	0.0	-1.5
Condit. Reinf. active minus inactive responses	0.1	0.2	1.1	0.1	0.2	0.2	-0.2	0.2	1.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.5	-0.4	-0.4	0.2	-0.3	0.4
Condit. Reinf. active responses	0.4	0.5	1.9	-0.1	0.4	0.6	-0.6	0.6	1.4
Condit. Reinf. inactive responses	1.2	1.8	3.1	0.7	1.4	1.8	-1.6	1.5	0.9
Condit. Reinf. lever presses	0.1	0.1	0.5	0.4	0.1	-0.1	0.1	-0.1	0.7
Condit. Reinf. lever reinforcers received	0.2	0.2	1.2	-0.4	0.1	0.3	-0.2	0.2	1.1
Conditioned reinforcement - actives	1.2	4.7	5.7	2.0	2.4	2.2	-2.2	2.2	2.2
Conditioned reinforcement - inactives	0.7	1.9	4.7	2.2	1.6	0.9	-1.0	0.9	1.3
Conditioned locomotion	0.8	1.2	5.8	0.6	0.7	0.4	-0.4	0.4	2.4
Patch foraging indifference point 0 sec	0.1	0.4	1.3	0.3	0.4	0.2	-0.6	0.6	-1.1
Patch foraging indifference point AUC	2.8	6.6	9.5	2.0	2.8	2.9	-3.1	3.1	0.8
Delay disc. indifference point, 0s delay	2.5	2.8	4.8	-0.7	-1.6	-2.0	2.2	-2.2	0.3
Delay disc. indifference point, 16s delay	0.9	1.2	4.0	1.1	1.0	0.6	-0.6	0.6	2.0
Delay disc. indifference point, 2s delay	2.2	2.4	12.6	1.1	0.6	-0.3	0.3	-0.3	3.5
Delay disc. indifference point, 24s delay	2.8	4.5	7.2	0.9	2.0	2.7	-2.7	2.7	-0.9
Delay disc. indifference point, 4s delay	0.4	0.5	2.2	0.1	-0.1	-0.5	0.5	-0.5	1.5
Delay disc. indifference point, 8s delay	0.4	0.7	2.0	1.4	1.0	0.6	-0.6	0.6	0.5
Indifference point function ln k	1.0	2.9	3.8	-1.8	-2.0	-1.6	1.8	-1.8	-1.0
Indifference point function log k	1.0	2.9	3.8	-1.8	-2.0	-1.6	1.8	-1.8	-1.0
Patch foraging total patch changes 0 sec	0.2	0.5	0.6	0.7	0.7	0.3	-0.8	0.8	-0.7
Patch foraging total patch changes 12 sec	1.7	2.2	3.6	0.8	1.6	1.8	-1.9	1.9	0.3
Patch foraging total patch changes 18 sec	0.6	1.5	2.3	1.0	1.3	1.2	-1.5	1.5	-0.1
Patch foraging total patch changes 24 sec	0.8	2.9	4.1	1.9	1.9	2.0	-1.8	1.8	-0.1
Patch foraging total patch changes 6 sec	0.8	1.4	2.5	1.0	1.4	0.7	-1.6	1.6	0.1
Patch foraging time to switch 0 sec	1.3	5.1	7.2	-1.8	-2.3	-2.7	2.7	-2.6	1.0
Patch foraging water rate 0 sec	0.4	1.5	5.2	0.5	0.6	1.1	-1.0	1.0	-2.3
Patch foraging water rate 12 sec	0.1	0.5	2.1	0.5	0.2	0.7	-0.2	0.1	-1.5
Patch foraging water rate 18 sec	1.2	2.6	4.8	0.5	1.1	1.9	-1.7	1.7	-2.2
Patch foraging water rate 24 sec	0.7	0.9	3.9	-1.1	-0.7	0.0	0.1	-0.1	-2.0
Patch foraging water rate 6 sec	0.8	1.1	2.9	1.2	0.7	1.1	-0.6	0.6	-1.7
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.8	-0.1	0.0	0.1	-0.0	0.1	0.9
Distance traveled before self-admin	0.4	0.9	1.6	-0.3	-0.6	-1.0	1.0	-1.0	1.3
Distance traveled after self-admin	0.2	0.3	1.0	-0.3	0.1	0.1	-0.5	0.5	-1.0
Extensor digitorum longus weight	0.9	3.6	7.0	0.2	-1.2	-2.7	2.3	-2.3	1.6
Bone: elastic displacement	0.9	1.1	2.0	-1.4	-1.2	-0.7	0.9	-0.9	-0.9
Bone: elastic work	3.3	4.3	7.8	-2.8	-2.4	-2.0	1.9	-1.9	-0.9
Bone: endosteal estimation	0.5	1.2	4.5	-2.1	-1.1	-0.4	0.4	-0.4	-0.9
Bone: endosteal perimeter	0.8	2.0	5.8	-2.4	-1.7	-0.7	1.0	-1.0	-1.1
Epididymis fat weight	0.6	3.1	4.4	-2.0	-1.9	-2.1	1.5	-1.5	-1.5
Delta time in closed arm before/after self-admin	0.8	0.8	1.3	1.1	0.9	0.5	-0.7	0.7	1.2
Delta time in open arm before/after self-admin	0.0	0.1	0.2	-0.4	-0.3	-0.0	0.2	-0.2	0.1
Diff in mean of infusions in LGA sessions	0.3	0.5	0.8	0.0	0.5	0.7	-0.9	0.9	-0.7
Delay discount exponential model param	0.6	0.9	2.6	-1.1	-0.9	-0.5	0.4	-0.4	-1.6
Extinction: sum of active levers before priming	0.2	0.3	1.5	0.0	0.3	0.2	-0.2	0.3	1.2
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.2	-0.2	0.2
Bone: final force	0.6	1.0	2.1	-1.4	-1.2	-0.9	0.9	-0.9	-0.3
Bone: final moment	0.8	1.3	2.5	-1.6	-1.3	-1.1	1.0	-1.0	-0.5
Food consumed during 24 hour testing period	0.1	0.1	0.3	0.0	0.3	0.6	-0.3	0.3	0.5
Glucose	0.6	0.9	1.4	0.1	-0.8	-1.1	1.1	-1.2	-0.8
Heart weight	2.2	3.6	7.1	-2.7	-2.0	-1.4	1.1	-1.1	-2.5
Delay discount hyperbolic model param	0.8	1.0	3.9	-1.1	-0.8	-0.3	0.3	-0.3	-2.0
Intermittent access intake day 1-15 change	0.1	0.5	0.7	0.8	0.8	0.6	-0.7	0.7	0.5
Intermittent access intake escalation	0.1	0.7	1.0	1.0	1.0	0.8	-0.9	0.9	0.4
Intermittent access intake escalation 2	0.1	0.2	0.7	0.8	0.5	0.4	-0.4	0.4	-0.1
Intermitt. access day 1 inactive lever presses	0.1	0.7	1.8	-0.8	-0.9	-0.6	0.6	-0.6	-1.3
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	0.3	0.2	0.0	-0.3	0.3	-0.3
Intermitt. access escalation Index	0.2	0.7	1.8	1.3	1.0	0.6	-0.6	0.6	0.6
Intermittent access day 1 total infusions	1.4	4.1	5.1	1.2	2.1	2.0	-2.2	2.2	2.3
Intermittent access day 15 total infusions	1.6	3.9	4.7	1.6	2.2	2.0	-2.1	2.1	1.9
Intermittent access terminal intake (last 3 days)	2.4	4.1	5.2	1.4	2.2	2.2	-2.3	2.3	1.7
Intermittent access total infusions	3.2	3.8	5.9	1.3	2.0	1.8	-2.0	1.9	2.4
Intermittent access day 1 locomotion	0.5	0.9	1.5	0.9	1.0	0.6	-0.9	0.9	1.2
Intermittent access day 15 total locomotion	0.2	0.7	0.8	0.8	0.9	0.7	-0.9	0.9	0.9
Intermittent access total locomotion	0.2	0.2	0.5	0.7	0.5	0.2	-0.4	0.4	0.6
Intermittent access standard deviation	0.1	0.3	0.7	-0.4	-0.6	-0.8	0.6	-0.6	0.4
Left kidney weight	1.1	8.8	28.2	-5.3	-3.3	-2.1	1.6	-1.6	-2.1
Right kidney weight	2.1	14.8	33.2	-5.8	-4.3	-3.5	2.8	-2.7	-3.0
Cocaine induced anxiety	0.3	0.9	1.3	-0.8	-1.0	-1.1	1.1	-1.1	0.4
Post-drug Anxiety	3.0	3.4	4.7	-1.3	-2.0	-2.2	2.1	-2.1	-1.1
Baseline Anxiety	0.1	0.2	1.1	0.3	-0.1	-0.2	0.2	-0.2	-1.0
Tail length	0.1	0.6	3.5	-0.0	-0.2	-0.4	0.0	-0.0	-1.9
Length with tail	0.5	2.1	6.4	-1.6	-1.2	-1.2	0.5	-0.5	-2.5
Length without tail	0.6	3.1	7.3	-2.7	-1.9	-1.2	1.0	-1.0	-2.0
Times rat made contact with spout	5.2	5.9	7.2	2.5	2.6	2.5	-2.7	2.7	-1.4
Lifetime Intake	2.8	3.4	5.9	1.3	1.9	1.7	-1.8	1.8	2.4
Liver weight, left	0.3	0.5	0.8	0.2	0.7	0.9	-0.9	0.8	0.6
Liver weight, right	0.2	0.4	1.6	-0.6	-0.1	0.1	-0.5	0.4	-1.3
Locomotor activity	0.2	0.3	0.7	-0.8	-0.6	-0.5	0.3	-0.3	-0.8
Locomotor testing distance	0.1	0.3	0.9	1.0	0.5	0.3	-0.3	0.2	-0.4
Locomotor testing rearing	0.0	0.2	0.3	-0.0	0.4	0.5	-0.6	0.5	-0.1
Locomotion in novel chamber	0.4	0.6	1.9	1.4	0.6	-0.1	-0.0	0.1	1.1
Locomotion in novel chamber post-restriction	0.4	1.2	2.6	1.6	1.1	0.7	-0.5	0.5	1.6
Fecal boli incidents, locomotor time 1	0.3	0.9	1.7	0.2	0.7	1.3	-1.1	1.1	-0.6
Change in fecal boli incidents, locomotor task	1.4	1.5	2.4	0.2	1.0	1.3	-1.5	1.5	-1.3
Time >=10cm from walls, locomotor time 1	0.2	0.3	1.1	-1.0	-0.6	-0.4	0.3	-0.3	-0.0
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.1	0.3	0.4	-0.4	0.4	-0.4
Total resting periods, locomotor time 1	0.1	0.1	0.4	-0.3	-0.2	-0.1	0.1	-0.1	-0.6
Rest time, locomotor task time 1	0.2	0.3	1.4	-0.5	-0.4	-0.2	0.2	-0.2	-1.2
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.3	-0.1	0.1	0.0	-0.1	0.2
Vertical activity count, locomotor time 1	0.1	0.5	1.2	0.1	-0.6	-0.5	0.7	-0.7	-1.1
Time >=10cm from walls, locomotor time 2	0.3	0.8	3.6	-0.9	-0.5	0.0	-0.2	0.2	-1.9
Bouts of movement, locomotor time 2	0.2	0.7	2.8	0.8	0.2	-0.7	0.4	-0.5	1.7
Total resting periods, locomotor time 2	0.2	0.9	3.8	0.9	0.3	-0.6	0.3	-0.3	1.9
Rest time, locomotor task time 2	0.0	0.0	0.0	0.1	-0.0	0.0	0.1	-0.1	-0.1
Distance moved, locomotor task time 2	0.3	0.5	1.4	-0.8	-0.6	-0.1	0.4	-0.4	-1.2
Vertical activity count, locomotor time 2	0.3	0.8	3.2	-0.3	-0.7	-0.4	0.6	-0.6	-1.8
Light reinforcement 1	0.0	0.1	0.3	-0.1	0.1	0.5	-0.1	0.1	0.2
Light reinforcement 2	0.2	0.3	0.6	-0.5	-0.6	-0.2	0.7	-0.7	0.7
Bone: marrow area	0.5	1.2	4.7	-2.2	-1.1	-0.3	0.3	-0.3	-0.9
Bone: maximum diameter	1.1	2.2	5.9	-2.4	-1.8	-0.8	1.1	-1.1	-1.0
Bone: maximum force	0.5	0.9	2.2	-1.5	-1.2	-0.8	0.8	-0.8	-0.2
Bone: maximum moment	0.6	1.2	2.7	-1.7	-1.2	-1.0	0.9	-0.9	-0.3
Mean time between licks in bursts	0.3	1.6	3.4	-1.0	-1.1	-1.8	1.3	-1.2	1.0
Mean num. licks in bursts	0.2	0.5	0.9	0.5	0.7	0.1	-0.9	0.9	-0.9
Cd content in liver	1.0	1.1	1.4	0.6	1.1	1.2	-1.2	1.2	0.7
Co content in liver	0.1	0.2	0.5	0.7	0.3	0.4	0.1	-0.1	0.5
Cu content in liver	1.0	1.2	4.0	2.0	1.3	0.2	-0.8	0.8	0.3
Fe content in liver	3.3	4.1	8.4	-2.9	-2.3	-1.9	1.7	-1.6	-1.4
K content in liver	0.1	0.1	0.1	0.4	0.4	0.2	-0.3	0.3	-0.2
Mg content in liver	0.2	0.2	0.4	0.4	0.5	0.4	-0.6	0.6	-0.3
Mn content in liver	0.9	1.0	1.3	1.0	1.1	1.0	-1.0	1.0	0.9
Na content in liver	0.3	0.4	0.8	-0.1	-0.4	-0.9	0.5	-0.5	-0.8
Rb content in liver	0.0	0.0	0.1	-0.1	0.0	0.3	-0.1	0.1	-0.3
Se content in liver	0.4	0.4	0.7	0.8	0.7	0.6	-0.4	0.5	0.8
Sr content in liver	1.0	0.9	3.8	2.0	0.8	-0.3	0.1	-0.1	0.8
Zn content in liver	1.2	1.3	2.1	1.1	1.3	1.1	-1.4	1.4	0.2
Bone: minimum diameter	0.0	0.1	0.4	-0.6	-0.3	-0.1	0.1	-0.1	-0.0
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.5	-0.1	-0.2	-0.2	0.2	-0.5
Time in novel zone, hab. session 1	0.1	0.2	0.3	-0.5	-0.5	0.1	0.5	-0.4	0.1
Total zone transitions, hab. session 1	2.7	3.7	5.0	2.1	2.2	2.0	-1.9	1.9	1.2
Total locomotion distance, hab. session 1	2.2	3.1	5.3	1.7	1.9	2.3	-1.8	1.8	0.7
Locomotion velocity, hab. session 1	2.1	3.0	4.6	1.8	1.9	2.2	-1.7	1.7	0.7
Time in familiar zone, hab. session 2	0.2	0.2	0.3	0.5	0.5	0.3	-0.5	0.5	0.3
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	0.1	-0.0	0.1	-0.1	0.4
Total zone transitions, hab. session 2	2.9	3.7	6.2	1.4	2.0	2.5	-2.2	2.2	0.0
Total locomotion distance, hab. session 2	0.9	1.2	1.9	0.7	1.2	1.4	-1.3	1.3	0.4
Locomotion velocity, hab. session 2	0.8	1.1	1.7	0.7	1.1	1.3	-1.3	1.3	0.1
Novel to familiar place preference ratio	0.1	0.1	0.4	-0.6	-0.0	0.3	-0.3	0.4	-0.4
Novelty place preference	0.2	0.2	0.3	-0.5	0.1	0.6	-0.5	0.5	-0.5
Time in novel zone, NPP test	0.2	0.2	0.5	-0.5	0.1	0.7	-0.5	0.5	-0.5
Total zone transitions, NPP test	3.9	5.8	8.8	2.2	2.6	3.0	-2.6	2.6	1.1
Total locomotion distance, NPP test	1.8	2.5	5.0	0.8	1.6	2.2	-1.8	1.8	0.5
Locomotion velocity, NPP test	1.7	2.5	4.5	1.1	1.6	2.1	-1.8	1.7	0.6
Intraocular pressure	0.1	0.2	0.4	-0.6	0.1	0.3	-0.5	0.5	0.1
Delta distance traveled before/after self-admin	2.4	2.6	5.4	-0.1	0.9	1.6	-1.9	1.9	-2.3
Delta ambulatory time before/after self-admin	1.8	3.1	4.6	-0.2	1.1	1.9	-2.2	2.1	-2.1
Parametrial fat weight	0.8	1.8	4.7	-0.3	-1.1	-1.3	1.2	-1.2	-2.2
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.2	0.0	0.4	-0.1	0.1	0.4
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	0.3	-0.0	-0.5	0.3	-0.4	0.7
Pavlov. Cond. change in total contacts	1.0	1.0	1.4	1.2	1.2	0.8	-1.0	0.9	1.0
Pavlov. Cond. index score	0.0	0.0	0.1	0.3	0.1	-0.2	-0.1	0.0	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.2	0.2	-0.1	-0.4	0.2	-0.2	-0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.5	0.0	-0.5	0.2	-0.2	-0.5
Pavlov. Cond. magazine entry number	0.3	0.4	0.9	-0.9	-0.8	-0.4	0.6	-0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.2	0.8	0.7	1.1	-0.7	0.7	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.2	0.5	0.3	-0.1	-0.2	0.1	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.3	0.6	0.2	-0.2	-0.0	-0.0	-0.1
Pavlov. Cond. lever latency	0.8	1.1	1.4	0.8	1.2	1.1	-1.2	1.2	0.8
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	0.6	0.0	-0.4	0.4	-0.4	0.4
Pavlov. Cond. change in total contacts	2.0	4.9	6.3	-2.4	-2.4	-2.5	2.0	-2.0	-1.9
Pavlov. Cond. index score	0.4	0.6	1.0	-0.4	-0.8	-1.0	0.9	-0.8	-0.7
Pavlov. Cond. latency score	0.4	0.6	0.9	-0.3	-0.8	-0.9	0.9	-0.8	-0.8
Pavlov. Cond. lever contacts	0.5	0.8	0.9	-0.6	-0.9	-1.0	0.9	-0.9	-0.8
Pavlov. Cond. magazine entry number	0.3	0.4	0.8	0.3	0.6	0.9	-0.7	0.7	0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.5	0.3	0.4	0.7	-0.5	0.5	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.6	1.0	1.6	-0.5	-1.0	-1.3	1.1	-1.1	-0.5
Pavlov. Cond. response bias	0.6	0.9	1.3	-0.7	-1.0	-1.1	1.0	-1.0	-0.4
Time in closed arm before self-admin	1.0	1.7	3.3	-0.0	-1.2	-1.4	1.8	-1.8	-0.2
Time in closed arm after self-admin	0.1	0.1	0.3	0.6	0.1	-0.2	0.1	-0.1	-0.4
Time in open arm before self-admin	0.4	0.5	0.8	0.3	0.6	0.7	-0.9	0.9	-0.9
Time in open arm after self-admin	0.0	0.0	0.0	0.1	0.0	0.2	0.0	0.0	-0.0
Bone: periosteal estimation	0.5	1.2	3.9	-2.0	-1.3	-0.6	0.7	-0.7	-0.7
Bone: periosteal perimeter	0.9	1.7	5.4	-2.3	-1.4	-0.6	0.6	-0.6	-1.4
Bone: post-yield work	0.2	0.3	0.6	0.0	0.5	0.8	-0.7	0.7	0.3
Progressive ratio test 1 active lever presses	1.5	2.6	4.3	1.0	1.6	1.5	-1.7	1.7	2.1
Progressive ratio test 1 breakpoint	1.6	2.8	3.8	1.0	1.7	1.6	-1.8	1.8	1.9
Progressive ratio test 1 inactive lever presses	0.4	1.1	4.1	0.0	-0.4	-0.9	0.8	-0.8	2.0
Progressive ratio test 2 active lever presses	3.0	4.3	5.2	2.0	2.3	2.0	-2.1	2.1	1.9
Progressive ratio test 2 breakpoint	3.3	4.2	5.0	1.9	2.2	2.0	-2.0	2.0	2.1
Progressive ratio test 2 inactive lever presses	1.3	4.2	5.9	2.4	2.4	1.9	-2.0	1.9	1.7
Incentive Sensitization - Responses	0.6	1.7	2.4	1.5	1.5	1.3	-1.3	1.3	0.9
Incentive Sensitization - Breakpoint	0.7	1.7	2.2	1.5	1.5	1.2	-1.2	1.2	1.0
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.7	-0.5	-0.8	-1.3	0.8	-0.8	-0.1
Progressive ratio	0.0	0.1	0.2	-0.4	-0.3	-0.3	0.3	-0.3	0.4
Food seeking constrained by brief footshock	0.1	0.2	0.4	0.2	0.4	0.6	-0.2	0.3	0.6
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.2	0.1	0.3	-0.1	0.1	-0.1
Retroperitoneal fat weight	2.2	9.8	13.1	-3.4	-3.6	-3.0	3.2	-3.2	-2.2
Reaction time number correct	1.1	3.9	5.8	1.7	2.3	1.9	-2.4	2.4	0.3
Reaction time mean minus median	0.0	0.1	0.2	-0.4	-0.4	-0.2	0.4	-0.4	0.0
Reaction time mean minus median AUC	0.1	0.4	0.6	-0.5	-0.7	-0.7	0.7	-0.7	-0.2
Reaction time num false alarms	0.1	0.1	0.2	0.4	0.4	0.1	-0.4	0.4	0.1
Reaction time num false alarms AUC	0.2	0.4	0.6	0.6	0.7	0.5	-0.8	0.8	0.3
Reaction time trials correct on left	1.1	3.9	5.8	1.7	2.3	1.9	-2.4	2.4	0.3
Reaction time trials on left	1.2	4.2	6.2	1.8	2.4	2.0	-2.5	2.5	0.5
Reaction time mean	0.9	1.9	2.6	-1.2	-1.6	-1.4	1.6	-1.6	-0.8
Reaction time mean AUC	0.4	0.9	1.3	-0.9	-1.1	-0.9	1.1	-1.1	-0.5
Median of all reaction times	1.4	2.2	3.0	-1.3	-1.7	-1.6	1.7	-1.7	-0.8
Reaction time omissions	0.7	1.2	6.1	0.7	0.6	-0.5	-0.1	0.1	2.5
Reaction time false alarm rate	0.3	0.4	0.6	-0.3	-0.6	-0.8	0.7	-0.7	0.2
Reaction time premature initiation rate	0.2	0.3	0.4	-0.6	-0.6	-0.3	0.6	-0.6	-0.5
Reaction time premature initiations	0.1	0.3	0.5	0.3	0.5	0.7	-0.6	0.6	-0.2
Std. dev. reaction times	0.1	0.4	0.6	-0.7	-0.8	-0.6	0.6	-0.7	-0.5
Reaction time trials completed	1.2	4.2	6.2	1.8	2.4	2.0	-2.5	2.5	0.5
Reaction time trials AUC	1.1	3.7	5.6	1.6	2.2	1.9	-2.4	2.4	0.4
Run reversals in cocaine runway, females	0.3	0.3	1.4	-0.3	-0.3	-0.3	0.1	0.2	-1.2
Run reversals in cocaine runway, males	4.0	4.4	7.8	0.5	2.0	2.8	-2.7	2.7	0.1
Latency to leave start box in cocaine runway	1.2	1.6	2.9	-1.7	-1.5	-1.2	1.3	-1.1	0.5
Latency to leave start box in cocaine runway, F	1.1	1.3	2.5	-1.6	-1.4	-1.1	1.2	-0.9	0.1
Latency to leave start box in cocaine runway, M	0.4	0.4	0.5	-0.7	-0.6	-0.6	0.7	-0.7	0.6
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.6	-0.3	-0.0	0.0	-0.0	-0.5
Total sessions with >9 infusions	0.6	0.8	1.8	-0.2	0.6	0.9	-0.9	0.9	1.3
Short access day 1 total inactive lever presses	0.2	0.3	1.4	-1.2	-0.5	-0.1	-0.2	0.1	-0.4
Short access day 10 total inactive lever presses	0.2	1.5	8.4	-0.4	-0.2	0.2	-0.4	0.3	-2.9
Short access day 1 total infusions	0.1	0.2	0.4	-0.2	0.3	0.6	-0.6	0.6	-0.2
Short access day 10 total infusions	0.9	1.5	2.3	0.1	1.1	1.3	-1.3	1.3	1.5
Short access total infusions	1.1	1.5	2.5	0.3	1.2	1.3	-1.4	1.3	1.6
Short access day 1 locomotion	0.1	0.2	0.4	-0.1	0.3	0.6	-0.6	0.6	0.2
Short access day 10 total locomotion	0.1	0.6	1.0	0.3	-0.6	-1.0	0.9	-0.9	-0.7
Short access total locomotion	0.1	0.1	0.3	-0.0	-0.2	-0.5	0.3	-0.3	0.5
One hour access (0.3 mA shock)	7.6	9.1	11.4	3.1	3.4	2.9	-2.9	2.9	2.8
Compulsive drug intake	0.7	1.0	1.9	1.4	1.1	0.9	-1.0	1.0	-0.3
One hour access (shock baseline)	0.7	1.9	5.5	1.0	1.3	1.0	-1.1	1.0	2.4
Social response proportion	4.4	5.6	7.5	-2.2	-2.5	-2.2	2.7	-2.7	1.6
Social responses	0.3	0.3	1.8	-0.1	0.1	0.6	0.1	-0.1	1.3
Social time	0.3	0.4	1.5	0.9	0.4	0.3	0.2	-0.2	1.2
Soleus weight	0.3	1.0	3.0	1.4	0.3	-1.0	0.1	-0.1	-1.7
Bone: stiffness	1.0	1.8	2.6	-1.6	-1.6	-1.1	1.4	-1.4	-0.7
Tibialis anterior weight	0.6	2.2	5.8	2.3	0.7	-0.9	0.6	-0.6	2.4
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.8	0.0	-0.1	-0.4	0.2	-0.2	0.9
Time to tail flick, vehicle, after self-admin	0.1	0.3	1.4	0.0	0.0	0.2	-0.3	0.3	-1.2
Time to tail flick, test, before self-admin	1.4	1.6	2.2	1.3	1.4	0.9	-1.2	1.2	1.5
Time to tail flick, test, after self-admin	0.4	0.4	1.0	0.5	0.5	0.3	-0.7	0.7	-1.0
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	-0.5	-0.1	0.2	-0.4	0.4	-0.7
Delta time to tail flick, test, before/after SA	0.3	0.4	1.2	0.3	-0.3	-0.7	0.5	-0.4	-1.1
Tibia length	0.3	0.8	1.5	-1.2	-0.9	-0.8	0.6	-0.5	-1.0
Ambulatory time before self-admin	0.2	0.5	1.4	0.3	-0.2	-0.6	0.6	-0.6	1.2
Ambulatory time after self-admin	0.6	0.9	1.6	0.4	0.8	0.9	-1.3	1.2	-1.0
Bone: tissue strength	0.7	0.7	0.9	-0.8	-1.0	-0.9	0.9	-0.9	-0.3
Total heroin consumption	1.3	1.6	2.2	1.0	1.3	1.1	-1.2	1.3	1.5
Bone: trabecular number	0.0	0.1	0.2	-0.2	-0.2	0.1	0.1	-0.1	-0.5
Bone: trabecular spacing	0.2	0.3	1.1	-0.6	-0.3	-0.7	0.0	-0.0	-1.1
Bone: trabecular thickness	0.1	0.1	0.3	0.3	-0.2	-0.2	0.5	-0.5	-0.2
Bone: trabecular tissue density	0.4	0.7	1.0	0.1	-0.7	-0.7	1.0	-1.0	-1.0
Water consumed over 24 hours	1.4	2.7	5.4	1.5	1.6	2.3	-1.6	1.7	-0.7
Number of responses in last shaping day	0.7	1.0	4.8	0.7	0.6	0.3	-0.2	0.2	2.2