Hub : Genes

Cdc42

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC alternative polyA NM_171994.5 0.09 0.06 9.3e-04 0.07 0.06 0.05 0.05 7.1e-04 1.7e-03 3.5e-03 3.1e-03
2 IC alternative polyA XM_008764287.4 0.1 0.06 4.8e-04 0.07 0.07 0.05 0.05 5.0e-04 9.6e-04 2.7e-03 2.7e-03
3 IC isoform ratio NM_171994.5 0.09 0.06 1.0e-03 0.07 0.06 0.04 0.06 6.1e-04 1.5e-03 7.6e-03 1.4e-03
4 Adipose mRNA stability Cdc42 0.12 0.07 4.9e-06 0.06 0.06 0.05 0.06 6.1e-07 6.2e-07 4.7e-06 2.2e-07
5 Brain mRNA stability Cdc42 0.09 0.06 5.5e-04 0.05 0.03 0.03 0.03 3.8e-05 6.5e-04 3.6e-04 4.4e-04
6 IC mRNA stability Cdc42 0.26 0.13 1.1e-03 0.09 0.07 0.1 0.08 1.9e-04 5.3e-04 7.6e-05 2.3e-04
7 Adipose gene expression Cdc42 0.06 0.05 1.0e-03 0.01 0 0 0 1.7e-02 1.7e-01 2.0e-01 8.9e-02
8 Liver mRNA stability Cdc42 0.03 0.03 3.5e-03 0.02 0.02 0.02 0.02 1.1e-03 2.5e-03 1.7e-03 2.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.10.3-0.20.2-0.2-0.5-0.6-0.5-0.3-0.3
Area under the delay curve0.40.50.7-0.70.7-0.70.70.80.80.70.7
BMI with tail0.72.33.70.8-0.80.81.71.61.81.91.9
BMI without tail0.72.15.62.4-2.42.4-0.0-0.00.10.10.1
Body weight1.14.98.62.9-2.92.9-1.7-1.9-1.6-1.5-1.5
Weight adjusted by age0.50.82.01.4-1.41.4-0.2-0.4-0.3-0.3-0.3
Bone surface0.20.30.5-0.20.2-0.2-0.7-0.7-0.6-0.6-0.6
Bone volume0.30.50.9-0.30.3-0.3-0.9-0.9-0.9-0.8-0.8
Breakpoint value in progressive ratio session0.70.82.21.5-1.51.5-0.0-0.0-0.0-0.0-0.0
Number of licking bursts0.10.10.20.3-0.30.30.40.40.40.30.3
Context. condit. distance diff. score0.30.30.90.9-0.90.9-0.00.00.10.20.2
Locomotion velocity, session 10.60.61.6-1.31.3-1.30.20.30.30.20.2
Locomotion distance, session 11.01.23.0-1.71.7-1.70.40.40.60.40.4
Locomotion velocity, session 21.82.15.4-2.32.3-2.3-0.2-0.4-0.2-0.2-0.2
Locomotion distance, session 20.81.11.7-1.31.3-1.3-1.0-1.0-0.7-0.7-0.7
Locomotion velocity, session 31.72.02.7-1.01.0-1.01.61.61.61.61.6
Locomotion distance, session 30.50.61.21.1-1.11.10.30.40.50.50.5
Stereotopy head waving bouts, day 30.60.81.9-1.41.4-1.40.10.2-0.1-0.3-0.3
Stereotopy head waving duration, day 30.40.40.9-1.01.0-1.0-0.1-0.1-0.4-0.5-0.5
Locomotion velocity, session 70.90.92.41.6-1.61.6-0.2-0.1-0.2-0.1-0.1
Locomotion distance, session 70.20.20.60.8-0.80.8-0.2-0.1-0.10.00.0
Stereotopy head waving bouts, day 70.00.10.10.4-0.40.4-0.00.0-0.0-0.1-0.1
Stereotopy head waving duration, day 70.30.30.50.3-0.30.3-0.7-0.7-0.6-0.7-0.7
Locomotion velocity, session 80.60.70.7-0.80.8-0.80.80.80.80.80.8
Locomotion distance, session 80.00.10.2-0.00.0-0.00.10.20.40.40.4
Degree of sensitization distance0.30.30.6-0.80.8-0.8-0.2-0.4-0.4-0.4-0.4
Degree of sensitization stereotypy0.80.81.61.2-1.21.2-0.7-0.7-0.6-0.6-0.6
Conditioned locomotion1.11.32.1-1.11.1-1.11.31.41.10.90.9
Cocaine response after cond. corrected0.40.40.9-0.20.2-0.20.90.90.80.70.7
Cocaine response after cond. not corrected0.20.20.40.2-0.20.20.60.60.50.40.4
Cocaine response before conditioning1.31.51.91.2-1.21.2-1.4-1.3-1.3-1.3-1.3
Saline control response0.60.81.4-0.40.4-0.40.90.91.01.21.2
Bone: connectivity density0.20.30.80.4-0.40.4-0.7-0.9-0.7-0.5-0.5
Bone: cortical apparent density0.70.92.51.6-1.61.6-0.0-0.0-0.2-0.1-0.1
Bone: cortical area0.81.21.81.0-1.01.0-1.3-1.0-1.1-1.1-1.1
Bone: cortical porosity0.60.71.4-1.21.2-1.2-0.5-0.4-0.5-0.5-0.5
Bone: cortical porosity0.80.91.6-1.31.3-1.3-0.7-0.6-0.7-0.7-0.7
Bone: cortical thickness0.20.40.91.0-1.01.0-0.4-0.2-0.2-0.1-0.1
Bone: cortical thickness0.40.40.8-0.20.2-0.20.70.80.80.90.9
Bone: cortical tissue density0.60.82.21.5-1.51.50.20.2-0.00.10.1
Condit. Reinf. active minus inactive responses0.50.60.6-0.80.8-0.8-0.6-0.7-0.8-0.8-0.8
Condit. Reinf. active-inactive response ratio0.40.40.6-0.60.6-0.6-0.5-0.7-0.8-0.7-0.7
Condit. Reinf. active responses1.92.33.7-0.50.5-0.5-1.8-1.9-1.9-1.9-1.9
Condit. Reinf. inactive responses2.22.74.70.1-0.10.1-2.2-2.2-2.0-2.1-2.1
Incentive salience index mean1.41.72.6-0.70.7-0.7-1.5-1.5-1.6-1.6-1.6
Condit. Reinf. lever presses2.13.05.1-0.00.0-0.0-2.1-2.1-2.3-2.2-2.2
Condit. Reinf. active minus inactive responses0.20.30.6-0.20.2-0.20.60.50.70.80.8
Condit. Reinf. active-inactive response ratio0.70.81.2-0.70.7-0.71.10.81.01.11.1
Condit. Reinf. active responses0.10.10.30.3-0.30.3-0.5-0.4-0.3-0.2-0.2
Condit. Reinf. inactive responses2.22.85.10.9-0.90.9-2.3-1.9-1.9-1.9-1.9
Condit. Reinf. lever presses0.60.91.4-0.80.8-0.8-1.2-1.1-1.0-0.9-0.9
Condit. Reinf. lever reinforcers received0.20.30.60.3-0.30.3-0.8-0.7-0.6-0.6-0.6
Conditioned reinforcement - actives1.32.23.01.1-1.11.1-1.6-1.7-1.7-1.6-1.6
Conditioned reinforcement - inactives0.60.91.11.0-1.01.0-1.0-1.0-0.9-0.9-0.9
Conditioned locomotion1.31.73.21.8-1.81.8-0.9-1.0-0.9-0.8-0.8
Patch foraging indifference point 0 sec0.00.00.10.3-0.30.30.00.10.10.10.1
Patch foraging indifference point AUC0.60.81.91.4-1.41.4-0.6-0.5-0.4-0.4-0.4
Delay disc. indifference point, 0s delay1.21.31.4-1.21.2-1.21.01.11.11.11.1
Delay disc. indifference point, 16s delay0.00.00.0-0.20.2-0.2-0.1-0.1-0.1-0.1-0.1
Delay disc. indifference point, 2s delay0.40.40.6-0.40.4-0.40.80.80.80.80.8
Delay disc. indifference point, 24s delay0.40.40.6-0.50.5-0.5-0.7-0.6-0.7-0.8-0.8
Delay disc. indifference point, 4s delay0.20.20.3-0.50.5-0.50.40.50.40.40.4
Delay disc. indifference point, 8s delay0.50.60.7-0.80.8-0.80.80.80.80.80.8
Indifference point function ln k1.93.38.8-3.03.0-3.00.20.20.1-0.0-0.0
Indifference point function log k1.93.38.8-3.03.0-3.00.20.20.1-0.0-0.0
Patch foraging total patch changes 0 sec0.00.00.00.0-0.00.00.00.20.10.10.1
Patch foraging total patch changes 12 sec1.41.82.91.7-1.71.7-1.2-1.1-1.0-1.0-1.0
Patch foraging total patch changes 18 sec0.50.81.41.2-1.21.2-0.8-0.6-0.7-0.7-0.7
Patch foraging total patch changes 24 sec0.50.91.51.2-1.21.20.60.80.70.80.8
Patch foraging total patch changes 6 sec1.11.64.42.1-2.12.1-0.2-0.1-0.0-0.0-0.0
Patch foraging time to switch 0 sec0.61.22.21.5-1.51.5-0.7-0.8-0.8-0.8-0.8
Patch foraging water rate 0 sec1.32.62.9-1.71.7-1.71.61.61.61.61.6
Patch foraging water rate 12 sec1.63.43.9-2.02.0-2.01.71.91.81.71.7
Patch foraging water rate 18 sec1.11.72.6-1.61.6-1.6-1.2-0.9-1.1-1.2-1.2
Patch foraging water rate 24 sec1.11.64.2-2.12.1-2.10.10.20.10.10.1
Patch foraging water rate 6 sec2.53.75.5-2.32.3-2.31.51.91.61.51.5
Seeking ratio, delayed vs. immediate footshock0.81.01.7-0.50.5-0.51.11.11.21.31.3
Distance traveled before self-admin2.12.76.82.6-2.62.6-0.6-0.6-0.5-0.5-0.5
Distance traveled after self-admin2.12.66.12.5-2.52.5-0.8-0.8-0.7-0.6-0.6
Extensor digitorum longus weight0.20.91.1-1.01.0-1.00.70.90.90.90.9
Bone: elastic displacement0.10.10.1-0.30.3-0.3-0.3-0.1-0.1-0.3-0.3
Bone: elastic work0.00.00.1-0.00.0-0.00.00.30.20.20.2
Bone: endosteal estimation1.12.44.30.5-0.50.5-1.9-1.7-2.0-2.1-2.1
Bone: endosteal perimeter0.51.01.5-0.80.8-0.8-1.1-0.9-1.1-1.2-1.2
Epididymis fat weight0.00.00.20.1-0.10.1-0.1-0.5-0.10.00.0
Delta time in closed arm before/after self-admin1.71.52.4-0.60.6-0.6-1.5-1.4-1.5-1.5-1.5
Delta time in open arm before/after self-admin0.10.10.10.3-0.30.3-0.2-0.2-0.2-0.2-0.2
Diff in mean of infusions in LGA sessions0.40.50.90.1-0.10.1-0.9-0.9-0.9-0.9-0.9
Delay discount exponential model param0.30.30.40.5-0.50.5-0.6-0.7-0.6-0.6-0.6
Extinction: sum of active levers before priming0.20.20.30.3-0.30.3-0.5-0.5-0.5-0.5-0.5
Active lever presses in extinction session 60.00.00.10.3-0.30.30.1-0.1-0.00.00.0
Bone: final force0.60.91.91.4-1.41.4-0.8-0.6-0.6-0.5-0.5
Bone: final moment0.40.61.01.0-1.01.0-0.8-0.5-0.6-0.5-0.5
Food consumed during 24 hour testing period0.40.61.51.2-1.21.2-0.30.1-0.2-0.4-0.4
Glucose1.21.95.02.2-2.22.20.20.10.10.10.1
Heart weight0.50.81.91.4-1.41.40.50.50.50.40.4
Delay discount hyperbolic model param0.30.40.50.7-0.70.7-0.6-0.6-0.6-0.6-0.6
Intermittent access intake day 1-15 change0.51.12.2-0.30.3-0.3-1.2-1.5-1.3-1.2-1.2
Intermittent access intake escalation0.51.01.8-0.30.3-0.3-1.2-1.4-1.2-1.2-1.2
Intermittent access intake escalation 21.11.21.8-0.80.8-0.8-1.2-1.2-1.3-1.3-1.3
Intermitt. access day 1 inactive lever presses1.14.14.72.1-2.12.1-2.2-1.8-1.9-2.0-2.0
Intermitt. access day 15 inactive lever presses0.30.71.51.2-1.21.2-0.6-0.4-0.5-0.5-0.5
Intermitt. access escalation Index1.01.42.00.7-0.70.71.21.41.41.41.4
Intermittent access day 1 total infusions3.04.911.03.3-3.33.3-1.2-1.1-1.1-1.1-1.1
Intermittent access day 15 total infusions2.03.04.52.1-2.12.1-1.5-1.4-1.4-1.5-1.5
Intermittent access terminal intake (last 3 days)2.63.43.61.9-1.91.9-1.9-1.8-1.8-1.8-1.8
Intermittent access total infusions3.44.06.72.6-2.62.6-1.6-1.6-1.5-1.5-1.5
Intermittent access day 1 locomotion0.70.92.41.5-1.51.5-0.1-0.2-0.1-0.0-0.0
Intermittent access day 15 total locomotion1.01.73.11.0-1.01.0-1.4-1.8-1.5-1.4-1.4
Intermittent access total locomotion1.92.33.71.9-1.91.9-1.2-1.4-1.2-1.1-1.1
Intermittent access standard deviation1.22.53.31.3-1.31.3-1.7-1.8-1.7-1.7-1.7
Left kidney weight4.822.232.05.7-5.75.7-4.2-4.2-4.0-3.9-3.9
Right kidney weight3.515.720.63.8-3.83.8-4.1-4.5-4.1-3.8-3.8
Cocaine induced anxiety0.40.61.00.3-0.30.3-0.9-1.0-0.9-0.9-0.9
Post-drug Anxiety0.10.10.2-0.50.5-0.5-0.2-0.4-0.2-0.1-0.1
Baseline Anxiety0.91.11.3-1.01.0-1.01.00.81.01.11.1
Tail length3.614.115.53.5-3.53.5-3.9-3.8-3.9-3.9-3.9
Length with tail3.113.415.33.5-3.53.5-3.8-3.9-3.7-3.6-3.6
Length without tail0.61.92.41.6-1.61.6-1.3-1.5-1.3-1.1-1.1
Times rat made contact with spout0.10.20.40.6-0.60.60.20.10.10.10.1
Lifetime Intake3.03.65.82.4-2.42.4-1.5-1.6-1.5-1.4-1.4
Liver weight, left3.45.68.41.3-1.31.3-2.9-2.8-2.8-2.8-2.8
Liver weight, right2.74.75.61.9-1.91.9-2.3-2.3-2.4-2.4-2.4
Locomotor activity0.50.71.61.3-1.31.3-0.6-0.4-0.4-0.4-0.4
Locomotor testing distance0.20.40.90.9-0.90.9-0.4-0.2-0.3-0.3-0.3
Locomotor testing rearing0.40.71.51.2-1.21.2-0.7-0.4-0.5-0.5-0.5
Locomotion in novel chamber4.05.18.20.8-0.80.82.72.82.92.82.8
Locomotion in novel chamber post-restriction0.20.40.6-0.10.1-0.1-0.8-0.8-0.7-0.7-0.7
Fecal boli incidents, locomotor time 12.94.37.82.8-2.82.8-1.5-1.5-1.5-1.4-1.4
Change in fecal boli incidents, locomotor task2.82.85.1-2.32.3-2.31.21.31.21.11.1
Time >=10cm from walls, locomotor time 11.31.43.41.8-1.81.8-0.4-0.6-0.5-0.4-0.4
Bouts of movement, locomotor time 11.51.73.00.1-0.10.11.71.71.71.61.6
Total resting periods, locomotor time 11.31.42.50.2-0.20.21.51.61.51.51.5
Rest time, locomotor task time 10.40.60.70.8-0.80.80.80.80.70.70.7
Distance moved, locomotor task time 10.30.51.0-1.01.0-1.00.40.30.50.60.6
Vertical activity count, locomotor time 10.30.61.5-1.21.2-1.20.20.20.30.40.4
Time >=10cm from walls, locomotor time 20.71.02.11.4-1.41.40.60.40.50.60.6
Bouts of movement, locomotor time 20.50.81.5-0.20.2-0.21.21.01.11.11.1
Total resting periods, locomotor time 20.61.01.9-0.30.3-0.31.41.21.21.21.2
Rest time, locomotor task time 20.60.71.31.1-1.11.10.70.70.60.60.6
Distance moved, locomotor task time 20.10.10.3-0.10.1-0.1-0.4-0.5-0.4-0.3-0.3
Vertical activity count, locomotor time 20.30.40.7-0.80.8-0.8-0.6-0.6-0.5-0.4-0.4
Light reinforcement 10.10.20.60.8-0.80.80.00.20.10.10.1
Light reinforcement 20.50.81.4-0.20.2-0.21.11.21.11.11.1
Bone: marrow area1.12.44.20.5-0.50.5-1.9-1.7-1.9-2.0-2.0
Bone: maximum diameter0.91.62.60.6-0.60.6-1.6-1.4-1.5-1.5-1.5
Bone: maximum force0.50.91.21.0-1.01.0-1.1-0.9-0.9-0.8-0.8
Bone: maximum moment0.40.71.30.7-0.70.7-1.1-0.8-1.0-0.9-0.9
Mean time between licks in bursts0.10.30.5-0.70.7-0.70.20.40.40.30.3
Mean num. licks in bursts0.10.20.20.4-0.40.4-0.4-0.5-0.4-0.4-0.4
Cd content in liver2.22.56.52.6-2.62.6-0.30.0-0.1-0.1-0.1
Co content in liver1.31.52.60.1-0.10.1-1.6-1.5-1.5-1.6-1.6
Cu content in liver0.10.10.30.6-0.60.60.30.10.20.20.2
Fe content in liver0.00.00.1-0.30.3-0.3-0.1-0.1-0.1-0.1-0.1
K content in liver0.00.00.0-0.10.1-0.10.10.0-0.0-0.0-0.0
Mg content in liver0.10.10.40.6-0.60.60.20.10.10.10.1
Mn content in liver0.70.81.21.1-1.11.1-0.8-0.7-0.8-0.8-0.8
Na content in liver0.50.61.0-0.10.1-0.1-1.0-0.9-0.9-1.0-1.0
Rb content in liver1.41.73.51.9-1.91.9-0.6-0.9-0.8-0.7-0.7
Se content in liver0.20.20.30.4-0.40.40.50.50.40.40.4
Sr content in liver1.31.13.0-1.71.7-1.70.00.20.20.20.2
Zn content in liver1.31.43.41.8-1.81.80.40.50.40.40.4
Bone: minimum diameter2.54.67.01.1-1.11.1-2.6-2.4-2.6-2.6-2.6
Time in familiar zone, hab. session 11.01.01.31.1-1.11.10.90.90.90.90.9
Time in novel zone, hab. session 10.00.00.0-0.10.1-0.10.10.00.00.10.1
Total zone transitions, hab. session 10.00.10.1-0.40.4-0.4-0.2-0.1-0.1-0.2-0.2
Total locomotion distance, hab. session 10.50.71.1-0.60.6-0.6-1.0-0.9-0.8-1.0-1.0
Locomotion velocity, hab. session 11.01.41.8-1.01.0-1.0-1.3-1.2-1.1-1.3-1.3
Time in familiar zone, hab. session 20.30.40.80.4-0.40.4-0.8-0.9-0.6-0.5-0.5
Time in novel zone, hab. session 21.21.22.2-0.60.6-0.61.41.51.21.21.2
Total zone transitions, hab. session 20.60.82.1-1.41.4-1.4-0.3-0.30.0-0.1-0.1
Total locomotion distance, hab. session 21.01.33.4-1.81.8-1.8-0.3-0.10.0-0.2-0.2
Locomotion velocity, hab. session 20.81.12.7-1.71.7-1.7-0.5-0.4-0.2-0.4-0.4
Novel to familiar place preference ratio0.40.51.31.1-1.11.1-0.1-0.1-0.2-0.2-0.2
Novelty place preference0.70.81.71.3-1.31.3-0.4-0.4-0.5-0.6-0.6
Time in novel zone, NPP test0.80.82.11.5-1.51.5-0.1-0.1-0.2-0.3-0.3
Total zone transitions, NPP test0.40.61.6-1.31.3-1.3-0.10.00.1-0.0-0.0
Total locomotion distance, NPP test0.81.12.2-1.51.5-1.5-0.7-0.6-0.5-0.7-0.7
Locomotion velocity, NPP test1.21.63.2-1.81.8-1.8-0.9-0.7-0.7-0.9-0.9
Intraocular pressure0.00.00.00.1-0.10.10.0-0.20.00.10.1
Delta distance traveled before/after self-admin0.30.30.40.4-0.40.4-0.6-0.6-0.6-0.6-0.6
Delta ambulatory time before/after self-admin0.00.00.0-0.00.0-0.0-0.1-0.2-0.1-0.1-0.1
Parametrial fat weight0.20.40.80.9-0.90.9-0.1-0.3-0.4-0.4-0.4
Pavlov. Cond. lever latency1.11.42.11.4-1.41.41.00.91.01.01.0
Pavlov. Cond. magazine entry latency0.00.00.10.1-0.10.1-0.2-0.1-0.2-0.2-0.2
Pavlov. Cond. change in total contacts0.60.61.5-1.21.2-1.2-0.1-0.0-0.2-0.2-0.2
Pavlov. Cond. index score0.30.40.5-0.60.6-0.6-0.6-0.5-0.7-0.7-0.7
Pavlov. Cond. latency score0.40.50.7-0.80.8-0.8-0.6-0.5-0.7-0.7-0.7
Pavlov. Cond. lever contacts1.21.52.9-1.71.7-1.7-0.8-0.7-0.9-0.8-0.8
Pavlov. Cond. magazine entry number0.30.40.6-0.60.6-0.60.70.60.70.70.7
Pavlov. Cond. intertrial magazine entries0.91.12.5-1.61.6-1.60.60.30.40.40.4
Pavlov. Cond. lever-magazine prob. diff.0.20.30.5-0.70.7-0.7-0.4-0.2-0.4-0.4-0.4
Pavlov. Cond. response bias0.50.60.8-0.50.5-0.5-0.9-0.7-0.9-0.9-0.9
Pavlov. Cond. lever latency0.20.20.50.3-0.30.30.70.60.50.40.4
Pavlov. Cond. magazine entry latency0.50.61.5-1.21.2-1.2-0.3-0.3-0.3-0.2-0.2
Pavlov. Cond. change in total contacts0.61.02.0-0.30.3-0.3-1.4-1.4-1.2-1.1-1.1
Pavlov. Cond. index score0.40.50.9-1.01.0-1.0-0.6-0.6-0.4-0.4-0.4
Pavlov. Cond. latency score0.30.51.2-1.11.1-1.1-0.3-0.3-0.2-0.1-0.1
Pavlov. Cond. lever contacts0.40.51.10.1-0.10.1-1.1-0.9-0.9-0.8-0.8
Pavlov. Cond. magazine entry number0.10.10.20.4-0.40.40.10.10.0-0.0-0.0
Pavlov. Cond. intertrial magazine entries0.10.20.40.1-0.10.1-0.3-0.3-0.5-0.6-0.6
Pavlov. Cond. lever-magazine prob. diff.0.40.51.0-1.01.0-1.0-0.7-0.6-0.5-0.4-0.4
Pavlov. Cond. response bias0.30.30.7-0.30.3-0.3-0.8-0.8-0.7-0.6-0.6
Time in closed arm before self-admin1.72.25.92.4-2.42.4-0.0-0.00.00.10.1
Time in closed arm after self-admin1.11.21.80.7-0.70.7-1.3-1.2-1.3-1.3-1.3
Time in open arm before self-admin0.70.71.3-1.11.1-1.10.70.60.70.70.7
Time in open arm after self-admin0.40.50.6-0.80.8-0.80.70.60.60.60.6
Bone: periosteal estimation1.32.84.40.9-0.90.9-2.1-1.7-2.0-2.1-2.1
Bone: periosteal perimeter0.91.52.60.3-0.30.3-1.6-1.3-1.5-1.6-1.6
Bone: post-yield work0.81.12.0-0.20.2-0.2-1.3-1.4-1.4-1.2-1.2
Progressive ratio test 1 active lever presses2.53.05.32.3-2.32.3-1.3-1.4-1.3-1.2-1.2
Progressive ratio test 1 breakpoint2.63.16.02.4-2.42.4-1.2-1.3-1.2-1.1-1.1
Progressive ratio test 1 inactive lever presses1.82.63.41.7-1.71.7-1.6-1.8-1.5-1.4-1.4
Progressive ratio test 2 active lever presses4.24.96.92.6-2.62.6-1.9-2.0-1.9-1.9-1.9
Progressive ratio test 2 breakpoint4.65.37.22.7-2.72.7-2.0-2.1-2.0-2.0-2.0
Progressive ratio test 2 inactive lever presses2.84.68.22.9-2.92.9-1.6-1.6-1.5-1.5-1.5
Incentive Sensitization - Responses3.14.45.42.3-2.32.3-2.0-1.9-2.0-2.0-2.0
Incentive Sensitization - Breakpoint3.54.55.22.3-2.32.3-2.0-2.0-2.0-2.0-2.0
Sum of active levers in priming session hrs 5-60.90.91.3-0.30.3-0.31.21.11.11.21.2
Progressive ratio0.00.00.10.1-0.10.1-0.3-0.0-0.1-0.2-0.2
Food seeking constrained by brief footshock1.82.32.71.6-1.61.6-1.4-1.4-1.4-1.4-1.4
Seeking ratio, punishment vs. effort0.20.20.30.5-0.50.5-0.4-0.5-0.5-0.4-0.4
Retroperitoneal fat weight0.20.91.71.3-1.31.3-0.5-0.8-0.7-0.6-0.6
Reaction time number correct0.30.61.1-1.11.1-1.10.50.70.50.40.4
Reaction time mean minus median0.61.51.71.3-1.31.31.11.01.21.31.3
Reaction time mean minus median AUC0.82.03.71.9-1.91.90.90.81.01.11.1
Reaction time num false alarms0.10.10.20.4-0.40.40.20.20.20.30.3
Reaction time num false alarms AUC0.10.10.20.2-0.20.20.30.30.30.40.4
Reaction time trials correct on left0.30.61.1-1.11.1-1.10.50.70.50.40.4
Reaction time trials on left0.30.61.2-1.11.1-1.10.50.70.50.40.4
Reaction time mean0.10.10.20.5-0.50.5-0.1-0.3-0.1-0.1-0.1
Reaction time mean AUC0.00.00.10.1-0.10.10.2-0.00.20.20.2
Median of all reaction times0.10.20.4-0.00.0-0.0-0.5-0.6-0.5-0.5-0.5
Reaction time omissions0.00.00.1-0.10.1-0.10.20.30.20.20.2
Reaction time false alarm rate0.10.20.40.6-0.60.60.2-0.00.20.30.3
Reaction time premature initiation rate0.60.90.9-0.90.9-0.91.00.90.90.90.9
Reaction time premature initiations0.91.62.1-1.41.4-1.41.11.21.11.01.0
Std. dev. reaction times0.50.91.20.7-0.70.71.00.81.01.11.1
Reaction time trials completed0.30.61.2-1.11.1-1.10.50.70.50.40.4
Reaction time trials AUC0.20.40.9-0.90.9-0.90.30.50.30.20.2
Run reversals in cocaine runway, females0.40.40.50.7-0.70.70.60.60.60.60.6
Run reversals in cocaine runway, males1.81.93.51.9-1.91.90.90.81.01.01.0
Latency to leave start box in cocaine runway0.20.20.6-0.80.8-0.80.10.00.00.00.0
Latency to leave start box in cocaine runway, F0.20.20.3-0.30.3-0.30.50.40.50.60.6
Latency to leave start box in cocaine runway, M0.70.71.2-1.11.1-1.1-0.5-0.5-0.6-0.7-0.7
Std. dev. time between licks in bursts0.00.00.1-0.20.2-0.2-0.20.0-0.1-0.1-0.1
Total sessions with >9 infusions1.82.22.61.5-1.51.5-1.5-1.6-1.4-1.4-1.4
Short access day 1 total inactive lever presses0.30.40.9-0.30.3-0.3-0.7-1.0-0.8-0.6-0.6
Short access day 10 total inactive lever presses0.10.10.30.6-0.60.6-0.10.1-0.0-0.1-0.1
Short access day 1 total infusions1.82.42.71.6-1.61.6-1.5-1.7-1.5-1.4-1.4
Short access day 10 total infusions2.33.04.52.1-2.12.1-1.5-1.6-1.4-1.3-1.3
Short access total infusions2.22.83.21.8-1.81.8-1.6-1.7-1.6-1.5-1.5
Short access day 1 locomotion0.30.40.40.6-0.60.6-0.6-0.6-0.6-0.5-0.5
Short access day 10 total locomotion1.22.23.61.9-1.91.9-1.2-1.3-1.2-1.1-1.1
Short access total locomotion1.62.03.71.9-1.91.9-1.0-1.1-1.0-0.9-0.9
One hour access (0.3 mA shock)2.52.94.12.0-2.02.0-1.5-1.6-1.5-1.4-1.4
Compulsive drug intake1.21.41.61.0-1.01.0-1.2-1.3-1.3-1.3-1.3
One hour access (shock baseline)0.40.61.51.2-1.21.2-0.5-0.4-0.3-0.3-0.3
Social response proportion0.00.10.10.0-0.00.00.30.20.30.30.3
Social responses0.10.20.20.4-0.40.40.40.50.50.40.4
Social time0.10.10.1-0.40.4-0.4-0.1-0.1-0.2-0.2-0.2
Soleus weight0.10.30.7-0.90.9-0.9-0.20.10.10.20.2
Bone: stiffness1.01.61.91.3-1.31.3-1.4-1.2-1.2-1.2-1.2
Tibialis anterior weight0.30.91.5-0.50.5-0.51.01.21.21.21.2
Time to tail flick, vehicle, before self-admin1.31.42.2-0.60.6-0.61.51.41.41.41.4
Time to tail flick, vehicle, after self-admin0.71.01.10.9-0.90.9-0.9-1.1-1.1-1.1-1.1
Time to tail flick, test, before self-admin0.30.40.60.3-0.30.30.70.80.70.70.7
Time to tail flick, test, after self-admin1.61.72.60.7-0.70.7-1.5-1.4-1.5-1.6-1.6
Delta time to tail flick, vehicle, before/after SA2.12.02.21.3-1.31.3-1.5-1.5-1.5-1.5-1.5
Delta time to tail flick, test, before/after SA1.41.52.3-0.50.5-0.5-1.4-1.4-1.5-1.5-1.5
Tibia length1.02.84.11.2-1.21.2-2.0-1.9-1.9-1.8-1.8
Ambulatory time before self-admin1.62.44.62.2-2.22.2-1.1-1.0-1.0-1.0-1.0
Ambulatory time after self-admin2.32.74.72.2-2.22.2-1.3-1.2-1.2-1.2-1.2
Bone: tissue strength0.40.40.8-0.00.0-0.0-0.9-0.9-0.7-0.7-0.7
Total heroin consumption0.30.30.50.7-0.70.70.40.50.40.50.5
Bone: trabecular number0.20.30.7-0.90.9-0.90.20.00.20.40.4
Bone: trabecular spacing0.00.00.10.0-0.00.00.20.30.20.20.2
Bone: trabecular thickness0.70.81.21.1-1.11.1-0.8-0.8-0.8-0.7-0.7
Bone: trabecular tissue density0.40.61.01.0-1.01.0-0.7-0.6-0.6-0.6-0.6
Water consumed over 24 hours0.00.00.10.0-0.00.0-0.20.1-0.2-0.3-0.3
Number of responses in last shaping day0.70.81.10.8-0.80.8-0.9-1.0-0.9-0.9-0.9