Cdc25a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Cdc25a	0.03	0.03	2.0e-03	0.02	0.02	0.01	0.02	2.0e-03	3.7e-03	1.7e-02	1.8e-03
2	Eye	mRNA stability	Cdc25a	0.26	0.16	4.1e-03	0.09	0.13	0.09	0.14	1.5e-02	5.4e-03	1.7e-02	3.4e-03
3	NAcc	gene expression	Cdc25a	0.03	0.02	5.1e-04	0.02	0.03	0.01	0.02	1.2e-03	2.7e-04	1.5e-02	7.8e-04
4	Adipose	mRNA stability	Cdc25a	0.03	0.02	4.5e-04	0.03	0.03	0.02	0.02	6.3e-04	6.2e-04	1.5e-03	1.1e-03
5	NAcc	mRNA stability	Cdc25a	0.03	0.02	3.4e-03	0.02	0.02	0	0.01	2.4e-03	5.6e-03	9.1e-02	7.1e-03
6	LHb	gene expression	Cdc25a	0.16	0.11	6.2e-03	0.06	0.04	-0.01	0.06	1.5e-02	4.4e-02	9.2e-01	2.0e-02
7	Adipose	gene expression	Cdc25a	0.04	0.03	8.9e-05	0.02	0.03	0.03	0.03	1.1e-03	4.4e-04	1.2e-04	4.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.1	0.2	1.6	-0.2	-0.2	-0.1	-0.2	0.1	-0.0	1.3
Area under the delay curve	2.2	2.4	4.0	1.5	1.5	1.4	1.4	-1.5	-1.3	2.0
BMI with tail	0.3	1.1	1.9	-1.3	-1.4	-1.1	-1.0	0.7	0.9	-0.4
BMI without tail	1.3	2.8	3.6	-1.7	-1.9	-1.9	-1.8	1.7	1.6	-0.6
Body weight	5.8	24.3	29.1	-5.4	-5.4	-5.2	-5.0	4.6	4.8	-4.0
Weight adjusted by age	0.6	0.6	1.9	-0.5	-0.5	-0.7	-0.6	0.8	0.8	-1.4
Bone surface	0.1	0.2	0.6	0.2	0.2	0.3	0.3	-0.4	-0.4	0.8
Bone volume	0.1	0.2	0.9	0.0	0.0	0.1	0.1	-0.2	-0.3	1.0
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.3	-0.3	-0.3	-0.4	0.4	0.5	0.4
Number of licking bursts	0.4	0.4	1.3	0.7	0.6	0.5	0.6	-0.4	-0.4	-1.1
Context. condit. distance diff. score	0.0	0.0	0.0	-0.0	0.0	-0.0	0.0	0.1	0.1	-0.1
Locomotion velocity, session 1	0.1	0.1	0.4	0.2	0.2	0.2	0.2	-0.3	-0.1	0.7
Locomotion distance, session 1	0.8	1.0	1.5	-1.2	-1.2	-1.0	-1.1	0.9	1.0	0.5
Locomotion velocity, session 2	0.2	0.2	0.3	0.5	0.4	0.5	0.6	-0.6	-0.5	0.3
Locomotion distance, session 2	0.2	0.3	1.7	-0.0	-0.0	0.2	0.1	-0.2	-0.1	1.3
Locomotion velocity, session 3	0.3	0.4	2.3	-0.4	-0.4	-0.3	-0.3	-0.1	0.4	1.5
Locomotion distance, session 3	1.6	1.7	4.4	1.0	1.0	1.1	1.1	-1.4	-1.1	2.1
Stereotopy head waving bouts, day 3	0.4	0.5	3.0	-0.1	-0.1	-0.2	-0.1	0.3	0.1	-1.7
Stereotopy head waving duration, day 3	0.4	0.5	2.0	-0.4	-0.3	-0.5	-0.5	0.6	0.5	-1.4
Locomotion velocity, session 7	0.2	0.2	1.4	-0.2	-0.2	-0.2	-0.3	0.2	0.3	1.2
Locomotion distance, session 7	1.2	1.6	3.1	1.2	1.2	1.2	1.1	-1.2	-1.0	1.8
Stereotopy head waving bouts, day 7	0.0	0.0	0.2	0.1	0.1	0.1	0.1	0.0	-0.2	0.5
Stereotopy head waving duration, day 7	0.3	0.4	0.5	-0.7	-0.7	-0.6	-0.6	0.7	0.6	-0.0
Locomotion velocity, session 8	0.3	0.4	1.0	-0.7	-0.6	-0.4	-0.4	0.3	0.4	1.0
Locomotion distance, session 8	0.5	0.7	3.0	-0.7	-0.6	-0.5	-0.5	0.5	0.5	1.7
Degree of sensitization distance	1.1	1.1	1.6	-0.9	-1.0	-1.0	-1.1	1.3	1.1	-1.1
Degree of sensitization stereotypy	0.1	0.1	0.5	-0.3	-0.3	-0.2	-0.3	0.3	0.3	0.7
Conditioned locomotion	2.9	3.4	3.6	1.9	1.9	1.9	1.8	-1.7	-1.9	1.9
Cocaine response after cond. corrected	0.7	0.8	4.1	-0.5	-0.5	-0.6	-0.4	0.7	0.5	-2.0
Cocaine response after cond. not corrected	2.2	2.5	4.7	-1.5	-1.4	-1.5	-1.4	1.5	1.4	-2.2
Cocaine response before conditioning	1.1	1.3	2.0	-1.4	-1.4	-1.2	-1.2	0.9	1.2	0.3
Saline control response	1.3	1.7	2.2	-1.3	-1.3	-1.3	-1.5	1.4	1.5	0.6
Bone: connectivity density	0.4	0.7	3.3	0.5	0.5	0.6	0.4	-0.4	-0.4	1.8
Bone: cortical apparent density	0.2	0.3	0.4	0.5	0.5	0.5	0.5	-0.5	-0.5	0.6
Bone: cortical area	0.4	0.5	2.3	0.5	0.5	0.4	0.6	-0.5	-0.6	-1.5
Bone: cortical porosity	0.2	0.3	1.6	0.2	0.2	0.2	0.1	-0.1	-0.1	1.3
Bone: cortical porosity	0.4	0.4	2.2	0.5	0.4	0.5	0.3	-0.3	-0.3	1.5
Bone: cortical thickness	0.5	0.8	5.3	-0.3	-0.3	-0.4	-0.2	0.2	0.2	-2.3
Bone: cortical thickness	0.0	0.0	0.1	0.0	0.1	0.0	0.1	-0.0	-0.1	-0.4
Bone: cortical tissue density	0.2	0.3	0.6	0.5	0.5	0.5	0.5	-0.5	-0.5	0.7
Condit. Reinf. active minus inactive responses	0.2	0.3	1.6	-0.2	-0.2	-0.2	-0.2	0.0	0.4	-1.3
Condit. Reinf. active-inactive response ratio	0.5	0.6	3.0	-0.3	-0.4	-0.5	-0.4	0.2	0.7	-1.7
Condit. Reinf. active responses	0.1	0.1	0.4	0.2	0.2	0.1	0.2	-0.1	-0.2	-0.6
Condit. Reinf. inactive responses	0.6	0.7	1.2	0.7	0.8	0.8	0.8	-0.5	-1.0	1.1
Incentive salience index mean	0.1	0.1	0.2	0.3	0.3	0.2	0.3	-0.3	-0.2	-0.4
Condit. Reinf. lever presses	1.3	1.7	1.9	1.4	1.4	1.4	1.4	-1.3	-1.4	1.0
Condit. Reinf. active minus inactive responses	1.7	2.1	2.8	-1.7	-1.7	-1.5	-1.5	1.1	1.5	-0.9
Condit. Reinf. active-inactive response ratio	1.4	1.5	1.8	-1.3	-1.3	-1.3	-1.2	1.0	1.3	-1.1
Condit. Reinf. active responses	1.6	2.2	2.9	-1.7	-1.7	-1.6	-1.6	1.2	1.6	-0.9
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.0	0.0	0.1	0.0	-0.1	-0.0	0.3
Condit. Reinf. lever presses	2.1	2.8	3.8	-1.9	-1.9	-1.8	-1.7	1.3	1.7	-1.2
Condit. Reinf. lever reinforcers received	1.8	2.5	3.2	-1.8	-1.8	-1.7	-1.6	1.3	1.7	-1.0
Conditioned reinforcement - actives	0.4	0.4	0.5	0.6	0.7	0.6	0.6	-0.6	-0.4	0.7
Conditioned reinforcement - inactives	1.2	1.4	1.7	1.2	1.2	1.1	1.2	-1.3	-1.1	-1.2
Conditioned locomotion	0.5	0.6	2.2	0.6	0.6	0.6	0.5	-0.5	-0.4	1.5
Patch foraging indifference point 0 sec	1.0	1.7	2.7	-1.2	-1.1	-1.4	-1.5	1.4	1.6	0.2
Patch foraging indifference point AUC	0.2	0.2	0.7	-0.2	-0.3	-0.2	-0.3	0.3	0.3	0.9
Delay disc. indifference point, 0s delay	0.0	0.0	0.2	0.1	0.2	0.2	0.1	-0.1	-0.1	0.5
Delay disc. indifference point, 16s delay	1.0	1.1	1.7	1.0	1.0	1.0	0.9	-1.0	-1.0	1.3
Delay disc. indifference point, 2s delay	0.3	0.3	0.5	0.6	0.6	0.5	0.5	-0.5	-0.4	0.7
Delay disc. indifference point, 24s delay	1.0	1.0	1.5	0.9	0.9	0.9	0.9	-1.1	-0.9	1.2
Delay disc. indifference point, 4s delay	1.8	1.9	2.4	1.6	1.6	1.4	1.4	-1.2	-1.2	1.4
Delay disc. indifference point, 8s delay	2.3	2.4	3.6	1.5	1.5	1.5	1.4	-1.5	-1.3	1.9
Indifference point function ln k	0.3	0.4	1.1	0.2	0.3	0.6	0.6	-1.0	-0.9	0.6
Indifference point function log k	0.3	0.4	1.1	0.2	0.3	0.6	0.6	-1.0	-0.9	0.6
Patch foraging total patch changes 0 sec	1.2	1.9	2.9	-1.3	-1.2	-1.5	-1.6	1.5	1.7	-0.3
Patch foraging total patch changes 12 sec	1.0	1.3	1.6	-1.1	-1.1	-1.2	-1.2	1.2	1.3	-0.7
Patch foraging total patch changes 18 sec	1.9	2.4	3.6	-1.5	-1.5	-1.6	-1.8	1.7	1.9	-0.6
Patch foraging total patch changes 24 sec	2.6	3.2	3.7	-1.9	-1.9	-1.9	-1.9	1.5	1.9	-1.5
Patch foraging total patch changes 6 sec	0.3	0.4	0.9	-0.3	-0.4	-0.5	-0.7	0.6	0.8	0.9
Patch foraging time to switch 0 sec	0.2	0.3	1.0	0.5	0.5	0.4	0.5	-0.3	-0.4	-1.0
Patch foraging water rate 0 sec	0.2	0.2	0.4	-0.6	-0.5	-0.5	-0.5	0.5	0.5	-0.4
Patch foraging water rate 12 sec	0.1	0.2	0.3	-0.5	-0.5	-0.5	-0.5	0.3	0.4	-0.2
Patch foraging water rate 18 sec	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.0	-0.0	-0.2	-0.3
Patch foraging water rate 24 sec	0.7	1.0	1.1	-1.0	-1.1	-1.0	-1.0	1.0	0.9	-1.1
Patch foraging water rate 6 sec	0.2	0.3	0.7	-0.8	-0.9	-0.5	-0.6	0.5	0.4	-0.0
Seeking ratio, delayed vs. immediate footshock	2.7	3.1	5.1	1.9	1.8	1.7	1.6	-1.3	-1.7	2.3
Distance traveled before self-admin	0.2	0.2	1.0	0.1	0.1	0.1	0.2	-0.4	-0.3	-1.0
Distance traveled after self-admin	0.3	0.4	0.5	0.6	0.7	0.6	0.6	-0.7	-0.7	-0.1
Extensor digitorum longus weight	0.1	0.5	0.7	0.8	0.8	0.7	0.8	-0.8	-0.7	-0.2
Bone: elastic displacement	0.2	0.2	1.1	-0.3	-0.3	-0.2	-0.2	0.0	0.1	-1.1
Bone: elastic work	0.5	0.6	1.5	-0.9	-0.9	-0.7	-0.6	0.5	0.5	-1.2
Bone: endosteal estimation	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.3	0.3	0.3	0.5
Bone: endosteal perimeter	1.0	2.1	2.3	1.5	1.5	1.5	1.5	-1.5	-1.5	1.2
Epididymis fat weight	0.2	0.5	0.7	-0.8	-0.8	-0.7	-0.7	0.4	0.7	-0.7
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	0.4	0.3	0.6	0.5	-0.6	-0.8	0.6
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.4	0.5	0.4	0.1
Diff in mean of infusions in LGA sessions	0.3	0.3	2.3	0.0	-0.1	-0.1	0.0	0.3	0.1	-1.5
Delay discount exponential model param	2.5	2.7	3.7	-1.7	-1.7	-1.6	-1.5	1.6	1.4	-1.9
Extinction: sum of active levers before priming	0.1	0.1	0.7	0.0	-0.0	-0.1	-0.1	0.2	0.3	0.8
Active lever presses in extinction session 6	0.4	0.3	0.9	-0.5	-0.4	-0.5	-0.6	0.2	0.7	0.9
Bone: final force	1.1	1.8	4.0	-1.2	-1.3	-1.2	-1.1	1.2	1.1	-2.0
Bone: final moment	1.4	2.3	5.2	-1.4	-1.5	-1.4	-1.2	1.4	1.3	-2.3
Food consumed during 24 hour testing period	1.4	1.7	2.2	-1.4	-1.5	-1.4	-1.3	1.1	1.2	-1.0
Glucose	0.3	0.4	0.6	-0.7	-0.8	-0.7	-0.7	0.7	0.5	0.6
Heart weight	3.2	4.6	9.0	-2.1	-2.2	-2.0	-1.8	2.0	1.7	-3.0
Delay discount hyperbolic model param	2.5	2.6	3.9	-1.7	-1.7	-1.6	-1.5	1.6	1.4	-2.0
Intermittent access intake day 1-15 change	0.9	0.9	1.7	0.8	0.7	0.8	0.9	-1.0	-0.8	-1.3
Intermittent access intake escalation	0.8	0.8	1.1	0.8	0.7	0.8	0.9	-1.0	-0.8	-1.1
Intermittent access intake escalation 2	0.6	0.5	3.5	-0.0	-0.2	0.0	0.2	-0.5	-0.2	-1.9
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.0	-0.1	-0.1	-0.1	0.1	0.1	-0.3
Intermitt. access day 15 inactive lever presses	0.6	0.6	1.0	1.0	1.0	0.8	0.9	-0.7	-0.6	-0.4
Intermitt. access escalation Index	0.1	0.1	0.7	-0.0	0.0	-0.0	-0.1	0.2	0.1	0.8
Intermittent access day 1 total infusions	0.1	0.1	0.3	0.2	0.3	0.1	0.1	0.1	0.1	0.6
Intermittent access day 15 total infusions	0.4	0.4	0.7	0.8	0.7	0.6	0.7	-0.7	-0.5	-0.1
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.3	0.6	0.5	0.4	0.4	-0.4	-0.2	0.1
Intermittent access total infusions	0.4	0.5	0.7	0.8	0.8	0.7	0.7	-0.7	-0.5	0.5
Intermittent access day 1 locomotion	0.2	0.2	0.9	0.5	0.6	0.3	0.3	-0.2	-0.1	1.0
Intermittent access day 15 total locomotion	1.0	1.0	1.6	0.9	0.9	1.0	0.9	-1.1	-1.0	1.3
Intermittent access total locomotion	1.2	1.4	2.5	1.1	1.1	1.1	1.0	-1.2	-1.0	1.6
Intermittent access standard deviation	0.7	0.8	4.8	-0.2	-0.3	-0.4	-0.2	-0.1	0.4	-2.2
Left kidney weight	0.8	2.4	3.6	-1.9	-1.9	-1.6	-1.6	1.3	1.4	0.8
Right kidney weight	0.3	0.9	1.8	-1.1	-1.1	-0.8	-0.9	0.6	0.7	1.3
Cocaine induced anxiety	0.2	0.2	0.5	0.7	0.7	0.3	0.4	-0.1	-0.0	-0.3
Post-drug Anxiety	0.1	0.1	0.2	0.4	0.4	0.2	0.3	0.0	-0.1	-0.1
Baseline Anxiety	0.6	0.6	1.0	0.6	0.6	0.8	0.8	-0.9	-1.0	0.7
Tail length	6.0	18.1	21.0	-4.3	-4.4	-4.5	-4.5	4.6	4.3	-3.0
Length with tail	8.6	31.6	35.0	-5.9	-5.9	-5.9	-5.8	5.6	5.6	-4.6
Length without tail	6.4	14.0	16.9	-4.1	-4.0	-3.8	-3.7	3.4	3.7	-3.4
Times rat made contact with spout	0.8	0.9	1.3	-0.9	-0.9	-0.9	-0.9	0.9	0.8	-1.1
Lifetime Intake	0.4	0.4	0.5	0.7	0.7	0.7	0.7	-0.7	-0.5	0.6
Liver weight, left	0.2	0.3	1.1	-0.2	-0.2	-0.2	-0.4	0.5	0.4	1.1
Liver weight, right	1.3	2.1	2.6	-1.6	-1.6	-1.5	-1.6	1.6	1.6	0.3
Locomotor activity	4.9	7.8	9.5	-2.9	-2.8	-3.0	-3.0	3.1	2.9	-1.7
Locomotor testing distance	4.0	6.7	7.9	-2.7	-2.6	-2.8	-2.8	2.8	2.8	-1.2
Locomotor testing rearing	0.0	0.1	0.1	-0.0	-0.0	-0.2	-0.3	0.3	0.3	-0.2
Locomotion in novel chamber	0.1	0.1	0.3	0.2	0.3	0.3	0.3	-0.4	-0.4	-0.5
Locomotion in novel chamber post-restriction	0.5	0.6	1.1	-1.0	-1.0	-0.8	-0.9	0.7	0.6	-0.1
Fecal boli incidents, locomotor time 1	0.5	0.6	1.0	-0.6	-0.6	-0.8	-0.7	1.0	0.8	-0.7
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.1	-0.1	0.0	0.0	-0.2	-0.0	0.3
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	0.3	0.3	0.5	0.4	-0.9	-0.7	0.9
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.1	-0.1	-0.2	-0.2	0.5	0.3	-0.2
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.2	0.4	0.2	-0.2
Rest time, locomotor task time 1	0.7	0.7	0.9	0.9	0.9	0.8	0.8	-0.6	-0.9	0.9
Distance moved, locomotor task time 1	1.8	2.0	3.1	-1.5	-1.6	-1.4	-1.3	1.0	1.1	-1.8
Vertical activity count, locomotor time 1	1.1	1.1	1.4	-1.1	-1.2	-1.1	-1.0	1.2	0.9	-1.0
Time >=10cm from walls, locomotor time 2	1.2	1.2	1.5	-1.2	-1.2	-1.2	-1.2	1.0	1.0	-0.8
Bouts of movement, locomotor time 2	0.1	0.1	0.3	0.3	0.2	0.2	0.2	-0.3	0.0	-0.6
Total resting periods, locomotor time 2	0.2	0.2	0.3	0.6	0.5	0.5	0.5	-0.5	-0.3	-0.2
Rest time, locomotor task time 2	0.1	0.2	0.5	0.4	0.4	0.3	0.2	0.2	-0.2	0.7
Distance moved, locomotor task time 2	1.3	1.5	2.7	-1.4	-1.4	-1.2	-1.1	0.7	1.0	-1.6
Vertical activity count, locomotor time 2	0.1	0.1	0.3	-0.5	-0.5	-0.3	-0.3	0.2	0.2	-0.5
Light reinforcement 1	0.6	1.1	1.8	-1.0	-1.1	-1.1	-1.1	1.3	1.0	-0.6
Light reinforcement 2	0.3	0.5	2.3	0.2	0.2	0.4	0.3	-0.4	-0.6	1.5
Bone: marrow area	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.3	0.4	0.3	0.5
Bone: maximum diameter	0.3	0.6	0.8	0.8	0.8	0.8	0.9	-0.7	-0.8	-0.8
Bone: maximum force	0.7	1.3	2.0	-1.1	-1.1	-1.1	-1.0	1.1	1.0	-1.4
Bone: maximum moment	0.9	1.5	2.6	-1.2	-1.2	-1.2	-1.1	1.2	1.1	-1.6
Mean time between licks in bursts	1.3	1.8	2.2	1.3	1.3	1.4	1.4	-1.5	-1.4	1.1
Mean num. licks in bursts	0.9	1.1	1.5	-1.2	-1.2	-1.0	-1.1	0.9	1.0	0.6
Cd content in liver	2.6	2.9	5.1	-1.4	-1.4	-1.6	-1.6	1.8	1.6	-2.3
Co content in liver	0.2	0.2	1.0	0.2	0.2	0.2	0.2	-0.4	-0.2	-1.0
Cu content in liver	3.7	4.5	6.5	-2.2	-2.1	-2.2	-2.2	2.6	2.2	-1.1
Fe content in liver	2.2	2.6	5.2	-1.2	-1.2	-1.4	-1.4	1.8	1.7	-2.3
K content in liver	0.9	0.9	1.3	-1.1	-1.0	-1.0	-1.0	1.1	0.9	0.1
Mg content in liver	0.1	0.1	0.3	-0.2	-0.2	-0.1	-0.0	0.1	-0.1	0.6
Mn content in liver	0.6	0.6	1.0	-1.0	-1.0	-0.8	-0.8	0.5	0.8	0.6
Na content in liver	0.4	0.4	0.7	-0.6	-0.5	-0.6	-0.7	0.8	0.8	-0.3
Rb content in liver	1.2	1.5	4.9	-0.6	-0.6	-1.0	-1.0	1.3	1.3	-2.2
Se content in liver	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.3	0.5	-0.0	-0.1
Sr content in liver	0.1	0.1	0.3	-0.3	-0.3	-0.1	-0.0	-0.1	-0.2	0.6
Zn content in liver	4.2	4.7	5.8	-2.3	-2.3	-2.3	-2.3	2.4	2.1	-1.2
Bone: minimum diameter	0.4	0.7	1.1	0.8	0.8	0.9	1.0	-1.0	-1.0	0.3
Time in familiar zone, hab. session 1	1.6	1.5	2.4	1.5	1.5	1.3	1.3	-0.9	-1.2	-0.3
Time in novel zone, hab. session 1	0.8	0.8	1.3	-1.1	-1.1	-0.9	-0.9	0.6	1.0	-0.3
Total zone transitions, hab. session 1	0.5	0.7	1.1	-1.0	-1.0	-0.8	-0.9	0.6	0.8	0.7
Total locomotion distance, hab. session 1	0.3	0.4	0.5	-0.7	-0.7	-0.6	-0.6	0.6	0.6	0.4
Locomotion velocity, hab. session 1	0.3	0.5	0.6	-0.7	-0.8	-0.6	-0.7	0.6	0.6	0.6
Time in familiar zone, hab. session 2	0.7	0.7	0.9	0.9	0.9	0.9	0.9	-0.8	-0.9	-0.6
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.2	-0.2	-0.2	-0.3	0.2	0.3	0.5
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.4	-0.4	-0.2	-0.2	0.1	0.2	0.5
Total locomotion distance, hab. session 2	0.3	0.4	0.6	-0.7	-0.7	-0.7	-0.7	0.8	0.5	0.4
Locomotion velocity, hab. session 2	0.3	0.4	0.5	-0.7	-0.7	-0.6	-0.6	0.7	0.5	0.5
Novel to familiar place preference ratio	1.1	1.2	3.3	-0.9	-1.0	-0.8	-1.0	1.0	0.8	1.8
Novelty place preference	1.2	1.2	3.6	-1.0	-1.0	-0.8	-1.0	0.9	0.8	1.9
Time in novel zone, NPP test	1.2	1.3	2.4	-1.1	-1.1	-0.9	-1.1	1.1	1.0	1.6
Total zone transitions, NPP test	2.1	3.0	4.5	-2.1	-2.1	-1.8	-1.8	1.5	1.7	0.8
Total locomotion distance, NPP test	1.0	1.4	2.0	-1.4	-1.4	-1.3	-1.2	1.2	1.2	0.0
Locomotion velocity, NPP test	1.1	1.6	2.3	-1.5	-1.5	-1.3	-1.3	1.2	1.2	0.3
Intraocular pressure	0.8	1.1	1.8	-0.9	-1.0	-1.1	-1.2	1.4	1.1	-0.7
Delta distance traveled before/after self-admin	0.2	0.2	0.7	0.4	0.5	0.2	0.2	-0.1	-0.2	0.9
Delta ambulatory time before/after self-admin	0.2	0.3	0.5	-0.4	-0.3	-0.6	-0.6	0.7	0.6	0.4
Parametrial fat weight	1.0	1.9	2.5	-1.5	-1.5	-1.5	-1.6	1.4	1.5	-0.4
Pavlov. Cond. lever latency	4.8	6.1	6.8	-2.6	-2.6	-2.5	-2.6	2.6	2.6	-1.6
Pavlov. Cond. magazine entry latency	5.8	7.5	8.9	3.0	3.0	2.9	3.0	-2.9	-2.8	1.1
Pavlov. Cond. change in total contacts	1.6	1.7	2.3	1.5	1.5	1.4	1.4	-1.3	-1.4	0.1
Pavlov. Cond. index score	5.8	7.4	8.7	3.0	3.0	2.9	2.9	-2.8	-2.8	1.1
Pavlov. Cond. latency score	5.7	7.3	8.5	2.9	2.9	2.8	2.9	-2.8	-2.8	1.4
Pavlov. Cond. lever contacts	2.6	3.0	3.5	1.8	1.8	1.8	1.9	-1.8	-1.9	1.1
Pavlov. Cond. magazine entry number	6.8	8.5	10.0	-3.2	-3.2	-3.1	-3.1	3.0	3.0	-1.2
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	-0.5	-0.5	-0.6	-0.6	0.6	0.4	-0.2
Pavlov. Cond. lever-magazine prob. diff.	5.2	6.4	7.8	2.8	2.8	2.7	2.8	-2.7	-2.7	0.7
Pavlov. Cond. response bias	6.3	7.6	9.0	3.0	3.0	2.9	3.0	-2.9	-2.9	1.0
Pavlov. Cond. lever latency	0.3	0.4	0.8	0.8	0.9	0.6	0.6	-0.3	-0.6	0.4
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	0.2	0.3	0.4	0.5	-0.6	-0.5	0.1
Pavlov. Cond. change in total contacts	1.9	2.7	3.5	-1.9	-1.8	-1.7	-1.6	1.4	1.6	-1.3
Pavlov. Cond. index score	0.1	0.1	0.2	-0.4	-0.4	-0.2	-0.2	-0.1	0.1	-0.3
Pavlov. Cond. latency score	0.0	0.1	0.1	-0.4	-0.3	-0.2	-0.1	-0.2	0.0	-0.2
Pavlov. Cond. lever contacts	0.7	1.0	1.6	-1.2	-1.3	-1.1	-1.1	0.7	1.0	-0.3
Pavlov. Cond. magazine entry number	0.4	0.4	0.7	-0.5	-0.6	-0.7	-0.7	0.9	0.8	-0.3
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.9	1.0	0.9	0.8	0.7	-0.6	-0.6	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.1	-0.4	-0.4	-0.2	-0.1	-0.1	0.1	-0.3
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.3	-0.4	-0.2	-0.1	-0.2	0.1	-0.1
Time in closed arm before self-admin	1.4	1.6	1.8	-1.4	-1.2	-1.3	-1.3	1.1	1.3	-1.3
Time in closed arm after self-admin	0.0	0.1	0.2	-0.2	-0.2	0.0	0.0	-0.1	-0.2	-0.5
Time in open arm before self-admin	0.8	0.9	1.1	1.0	0.9	1.0	1.0	-0.8	-1.1	0.7
Time in open arm after self-admin	0.6	0.7	3.5	0.5	0.5	0.5	0.4	-0.3	-0.5	1.9
Bone: periosteal estimation	0.0	0.0	0.3	0.0	-0.0	0.0	0.1	0.0	-0.0	-0.5
Bone: periosteal perimeter	1.0	1.7	2.1	1.4	1.4	1.4	1.4	-1.4	-1.4	0.3
Bone: post-yield work	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.1	0.2	0.0	0.3
Progressive ratio test 1 active lever presses	0.2	0.2	1.0	0.2	0.2	0.1	0.1	-0.3	0.1	1.0
Progressive ratio test 1 breakpoint	0.2	0.2	1.1	0.3	0.3	0.2	0.1	-0.3	0.0	1.1
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.6	0.8	0.8	0.6	0.7	-0.7	-0.4	-0.2
Progressive ratio test 2 active lever presses	0.8	0.9	1.2	1.1	1.1	0.9	0.9	-1.0	-0.7	0.8
Progressive ratio test 2 breakpoint	0.5	0.6	0.8	0.9	0.9	0.7	0.8	-0.8	-0.5	0.5
Progressive ratio test 2 inactive lever presses	1.5	1.7	2.8	1.6	1.7	1.3	1.5	-1.3	-1.1	-0.2
Incentive Sensitization - Responses	1.3	1.3	1.7	1.3	1.3	1.2	1.3	-1.2	-1.1	0.3
Incentive Sensitization - Breakpoint	1.2	1.3	1.7	1.3	1.3	1.2	1.2	-1.2	-1.0	0.3
Sum of active levers in priming session hrs 5-6	0.6	0.6	0.9	-0.8	-0.7	-0.8	-0.9	0.9	0.9	-0.0
Progressive ratio	3.3	3.8	4.6	-2.1	-2.1	-2.1	-2.1	2.1	1.9	-0.9
Food seeking constrained by brief footshock	0.7	0.9	1.5	0.7	0.7	1.0	1.0	-1.2	-1.2	0.3
Seeking ratio, punishment vs. effort	5.0	6.1	7.7	2.6	2.5	2.6	2.7	-2.8	-2.7	1.0
Retroperitoneal fat weight	0.4	1.4	2.3	-1.4	-1.5	-1.3	-1.3	0.9	1.1	-0.2
Reaction time number correct	0.5	0.8	1.3	0.9	0.8	0.9	0.9	-1.0	-1.1	-0.1
Reaction time mean minus median	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.3	0.3	0.2	0.4
Reaction time mean minus median AUC	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.5	0.5	0.4	0.3
Reaction time num false alarms	0.3	0.4	0.8	0.9	0.9	0.7	0.6	-0.6	-0.4	0.3
Reaction time num false alarms AUC	0.1	0.1	0.2	0.5	0.4	0.3	0.2	-0.3	-0.0	0.2
Reaction time trials correct on left	0.5	0.8	1.3	0.9	0.8	0.9	0.9	-1.0	-1.1	-0.1
Reaction time trials on left	0.6	0.8	1.4	0.9	0.8	0.9	0.9	-1.0	-1.2	-0.0
Reaction time mean	0.0	0.0	0.1	-0.1	-0.0	0.0	-0.0	-0.2	-0.0	0.3
Reaction time mean AUC	0.0	0.1	0.3	0.0	0.1	0.1	0.1	-0.3	-0.1	0.6
Median of all reaction times	0.0	0.0	0.2	-0.0	0.0	0.1	0.0	-0.4	-0.0	0.2
Reaction time omissions	0.2	0.3	0.5	0.7	0.7	0.5	0.5	-0.5	-0.4	-0.1
Reaction time false alarm rate	0.0	0.0	0.1	0.3	0.2	0.1	0.0	0.0	0.3	0.1
Reaction time premature initiation rate	2.1	2.8	3.9	-1.6	-1.7	-1.8	-1.8	1.7	2.0	-0.9
Reaction time premature initiations	0.9	1.2	1.6	-1.1	-1.2	-1.2	-1.2	1.0	1.3	-0.9
Std. dev. reaction times	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	0.2	0.3	0.5
Reaction time trials completed	0.6	0.8	1.4	0.9	0.8	0.9	0.9	-1.0	-1.2	-0.0
Reaction time trials AUC	0.7	1.0	1.7	1.0	0.9	1.1	1.0	-1.2	-1.3	0.1
Run reversals in cocaine runway, females	2.1	2.0	3.5	1.2	1.2	1.5	1.5	-1.8	-1.9	0.1
Run reversals in cocaine runway, males	1.2	1.1	2.4	-0.9	-0.9	-1.0	-0.9	1.0	1.1	-1.6
Latency to leave start box in cocaine runway	0.5	0.6	0.7	-0.7	-0.8	-0.8	-0.8	0.8	0.8	-0.6
Latency to leave start box in cocaine runway, F	1.8	1.9	4.0	-1.3	-1.3	-1.3	-1.2	1.2	1.2	-2.0
Latency to leave start box in cocaine runway, M	0.5	0.4	2.2	0.5	0.5	0.3	0.3	-0.2	-0.2	1.5
Std. dev. time between licks in bursts	4.3	5.2	6.5	2.4	2.4	2.4	2.6	-2.4	-2.5	-0.0
Total sessions with >9 infusions	0.2	0.2	0.7	0.4	0.4	0.4	0.5	-0.4	-0.4	-0.8
Short access day 1 total inactive lever presses	4.9	5.4	7.3	2.3	2.3	2.5	2.5	-2.7	-2.5	0.9
Short access day 10 total inactive lever presses	0.4	0.5	3.4	0.2	0.1	-0.1	0.0	0.1	0.2	-1.8
Short access day 1 total infusions	1.0	1.1	1.3	1.1	1.1	1.1	1.1	-1.1	-1.0	0.5
Short access day 10 total infusions	0.1	0.1	0.2	0.3	0.3	0.3	0.3	-0.4	-0.2	0.5
Short access total infusions	0.8	0.9	1.1	0.8	0.9	1.0	0.9	-1.1	-0.9	1.0
Short access day 1 locomotion	0.0	0.0	0.0	0.2	0.2	0.2	0.2	-0.1	-0.2	0.0
Short access day 10 total locomotion	0.1	0.1	0.5	-0.2	-0.2	-0.1	-0.2	-0.2	0.1	0.7
Short access total locomotion	0.1	0.1	0.9	0.1	0.1	0.0	-0.1	-0.0	0.2	0.9
One hour access (0.3 mA shock)	0.4	0.4	1.1	0.6	0.5	0.6	0.5	-0.6	-0.5	1.1
Compulsive drug intake	0.4	0.4	1.7	0.2	0.1	0.4	0.3	-0.3	-0.7	1.3
One hour access (shock baseline)	0.1	0.1	0.2	0.4	0.4	0.1	0.2	-0.1	0.2	-0.0
Social response proportion	0.6	0.6	0.9	-0.9	-0.9	-0.7	-0.8	0.6	0.7	-0.9
Social responses	0.4	0.5	0.7	-0.8	-0.9	-0.8	-0.8	0.8	0.8	-0.1
Social time	0.3	0.4	0.5	0.6	0.6	0.6	0.7	-0.7	-0.7	-0.7
Soleus weight	3.5	10.2	11.9	-3.5	-3.4	-3.4	-3.2	3.2	3.1	-2.5
Bone: stiffness	0.1	0.2	0.3	-0.4	-0.5	-0.4	-0.4	0.5	0.5	-0.5
Tibialis anterior weight	0.0	0.1	0.3	-0.2	-0.2	-0.2	-0.1	-0.0	-0.0	-0.5
Time to tail flick, vehicle, before self-admin	1.9	1.9	2.5	-1.5	-1.3	-1.4	-1.4	1.6	1.5	-0.9
Time to tail flick, vehicle, after self-admin	1.2	1.3	3.1	-1.0	-0.8	-1.1	-1.0	1.0	1.2	-1.8
Time to tail flick, test, before self-admin	0.3	0.3	1.0	-0.5	-0.5	-0.4	-0.5	0.2	0.3	1.0
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.2	0.3	0.1	0.1	0.1	0.0	-0.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	0.6	0.5	0.5	0.6	-0.7	-0.4	-0.7
Delta time to tail flick, test, before/after SA	0.3	0.3	0.5	0.6	0.7	0.5	0.6	-0.4	-0.3	-0.2
Tibia length	6.2	17.4	21.8	-4.7	-4.6	-4.5	-4.4	4.1	4.1	-2.3
Ambulatory time before self-admin	0.3	0.3	0.5	0.4	0.5	0.5	0.5	-0.7	-0.5	-0.6
Ambulatory time after self-admin	0.1	0.1	0.2	0.3	0.4	0.3	0.3	-0.5	-0.3	0.5
Bone: tissue strength	3.0	2.9	4.8	-1.6	-1.7	-1.6	-1.5	1.6	1.6	-2.2
Total heroin consumption	1.0	1.2	1.8	-1.0	-1.0	-1.1	-1.1	0.9	1.0	-1.3
Bone: trabecular number	1.0	1.6	5.5	0.9	0.9	1.1	0.9	-1.1	-1.1	2.4
Bone: trabecular spacing	1.8	2.3	6.3	-1.2	-1.2	-1.4	-1.2	1.4	1.3	-2.5
Bone: trabecular thickness	0.3	0.3	1.9	-0.4	-0.4	-0.2	-0.2	0.1	-0.0	1.4
Bone: trabecular tissue density	0.2	0.3	0.6	-0.6	-0.6	-0.6	-0.6	0.8	0.6	-0.0
Water consumed over 24 hours	0.2	0.2	1.3	-0.2	-0.2	-0.1	0.0	0.0	-0.0	-1.1
Number of responses in last shaping day	0.7	0.7	1.2	1.1	1.1	0.8	0.9	-0.8	-0.6	0.1