Hub : Genes

Cd7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Cd7 0.39 0.08 0.0e+00 0.5 0.52 0.53 0.53 6.9e-87 1.1e-91 3.3e-95 7.9e-96
2 BLA gene expression Cd7 0.4 0.15 2.6e-15 0.17 0.23 0.23 0.22 1.4e-09 1.2e-12 3.3e-12 5.8e-12
3 Adipose intron excision ratio chr10_106803955_106805132 0.02 0.02 1.0e-02 0.01 0.01 -0 0 5.8e-02 6.7e-02 5.6e-01 1.5e-01
4 IC gene expression Cd7 0.3 0.12 1.2e-11 0.27 0.26 0.25 0.27 6.7e-12 2.6e-11 5.8e-11 1.3e-11
5 pVTA gene expression Cd7 0.44 0.11 0.0e+00 0.54 0.54 0.54 0.54 1.4e-50 1.7e-51 9.3e-52 4.4e-51
6 Brain gene expression Cd7 0.32 0.1 0.0e+00 0.38 0.41 0.39 0.4 8.6e-38 2.5e-40 2.0e-38 5.3e-40
7 IL gene expression Cd7 0.28 0.14 1.7e-04 0.14 0.13 0.05 0.14 2.6e-04 5.5e-04 2.0e-02 2.5e-04
8 OFC gene expression Cd7 0.5 0.16 1.6e-08 0.2 0.26 0.23 0.24 2.0e-05 5.9e-07 3.1e-06 1.6e-06
9 Adipose gene expression Cd7 0.47 0.12 0.0e+00 0.54 0.55 0.56 0.55 1.9e-70 3.5e-72 4.6e-74 1.6e-72
10 PL gene expression Cd7 0.21 0.08 0.0e+00 0.22 0.21 0.2 0.21 4.7e-24 1.6e-22 1.1e-21 2.6e-22
11 LHb gene expression Cd7 0.64 0.15 5.0e-11 0.34 0.3 0.31 0.31 6.7e-09 8.7e-08 4.4e-08 3.5e-08
12 Liver gene expression Cd7 0.08 0.04 2.0e-07 0.05 0.05 0.04 0.04 2.2e-06 2.3e-06 8.2e-06 1.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.10.6-0.10.3-0.7-0.0-0.10.00.40.2-0.60.1-0.00.8
Area under the delay curve1.11.22.11.30.81.31.21.31.2-0.21.01.40.91.4-0.1
BMI with tail0.20.92.6-0.7-1.3-1.2-0.4-0.7-0.6-1.6-0.2-0.8-0.3-0.8-1.3
BMI without tail0.92.610.8-1.7-0.9-3.3-1.2-1.7-1.20.7-0.5-2.7-0.9-1.01.1
Body weight1.56.413.4-3.0-2.9-3.7-2.6-2.7-2.6-1.7-1.8-2.9-2.2-2.2-1.0
Weight adjusted by age1.11.72.8-1.4-1.3-1.6-1.4-1.6-1.5-0.6-1.2-1.4-1.2-1.7-0.4
Bone surface0.20.30.6-0.50.1-0.7-0.5-0.6-0.40.7-0.4-0.6-0.4-0.50.8
Bone volume0.10.30.8-0.50.1-0.8-0.4-0.5-0.30.6-0.2-0.7-0.2-0.40.9
Breakpoint value in progressive ratio session1.72.13.5-1.6-1.9-0.4-1.7-1.5-1.6-1.3-1.6-0.5-1.7-1.3-1.4
Number of licking bursts0.20.30.90.30.7-0.40.30.30.50.90.6-0.10.70.41.0
Context. condit. distance diff. score1.31.54.70.81.5-0.91.10.71.02.21.3-0.70.91.01.9
Locomotion velocity, session 11.01.13.70.2-0.61.70.00.2-0.1-1.8-0.61.6-0.1-0.6-1.9
Locomotion distance, session 12.73.55.52.31.41.72.12.32.0-0.41.92.12.22.0-0.3
Locomotion velocity, session 22.02.46.41.70.82.51.41.71.4-0.80.92.41.31.2-1.2
Locomotion distance, session 20.91.22.01.40.80.51.41.41.2-0.21.30.91.31.40.2
Locomotion velocity, session 30.80.93.10.6-0.01.70.40.80.5-1.10.11.70.50.6-1.2
Locomotion distance, session 32.02.25.11.50.72.21.21.71.4-0.91.02.31.41.5-1.1
Stereotopy head waving bouts, day 30.40.41.70.2-0.31.00.10.2-0.0-1.3-0.20.80.1-0.4-1.2
Stereotopy head waving duration, day 30.30.30.90.5-0.00.90.40.40.3-1.00.10.80.3-0.1-0.8
Locomotion velocity, session 70.80.91.31.01.11.10.81.11.00.90.81.01.01.10.5
Locomotion distance, session 73.95.07.22.72.41.72.62.62.61.32.41.92.42.40.8
Stereotopy head waving bouts, day 70.20.30.4-0.5-0.5-0.5-0.6-0.6-0.5-0.5-0.4-0.6-0.5-0.6-0.2
Stereotopy head waving duration, day 70.20.20.4-0.5-0.4-0.5-0.6-0.6-0.5-0.3-0.4-0.6-0.5-0.5-0.0
Locomotion velocity, session 81.31.62.71.61.00.41.61.51.40.31.60.91.51.50.4
Locomotion distance, session 82.53.65.91.92.0-0.72.21.81.91.92.4-0.02.02.22.1
Degree of sensitization distance0.70.73.00.10.8-1.10.5-0.10.21.70.5-1.00.10.11.6
Degree of sensitization stereotypy0.10.20.5-0.3-0.3-0.7-0.4-0.5-0.3-0.2-0.2-0.7-0.4-0.30.2
Conditioned locomotion1.51.76.0-1.0-0.1-2.5-0.5-1.2-0.71.4-0.2-2.3-0.8-0.41.8
Cocaine response after cond. corrected0.30.41.3-0.5-0.80.3-0.6-0.3-0.4-1.1-0.50.2-0.5-0.1-1.0
Cocaine response after cond. not corrected0.20.30.90.1-0.30.8-0.10.30.1-1.0-0.00.80.00.5-0.9
Cocaine response before conditioning1.41.72.91.41.40.91.31.61.50.91.41.21.51.70.7
Saline control response1.21.64.5-1.3-0.3-2.1-1.0-1.2-0.91.3-0.5-2.0-0.9-0.41.6
Bone: connectivity density0.50.71.80.71.2-0.30.80.60.81.20.9-0.10.80.71.3
Bone: cortical apparent density1.41.95.51.50.92.31.21.51.3-0.40.92.01.21.1-0.7
Bone: cortical area4.67.112.0-2.8-3.5-2.9-2.7-2.6-2.8-3.1-2.1-2.2-2.2-2.4-2.2
Bone: cortical porosity3.43.75.4-2.2-2.3-0.6-2.3-1.9-2.1-2.1-2.3-0.6-1.9-1.9-1.8
Bone: cortical porosity3.53.85.5-2.3-2.3-1.0-2.3-2.1-2.2-1.8-2.3-1.0-2.0-2.0-1.5
Bone: cortical thickness6.410.621.0-3.2-4.4-2.6-3.1-3.0-3.3-4.6-2.7-2.0-2.7-2.8-3.5
Bone: cortical thickness2.22.57.3-1.3-2.3-1.0-1.4-1.3-1.5-2.7-1.2-0.8-1.2-1.3-2.1
Bone: cortical tissue density1.42.06.01.51.02.51.21.51.3-0.30.92.11.31.1-0.6
Condit. Reinf. active minus inactive responses1.21.33.5-1.2-0.9-1.9-1.0-1.3-1.1-0.1-0.7-1.8-0.9-1.00.2
Condit. Reinf. active-inactive response ratio0.50.51.3-0.8-0.8-1.1-0.7-0.8-0.7-0.6-0.5-1.0-0.6-0.5-0.3
Condit. Reinf. active responses2.02.47.0-1.6-1.0-2.7-1.3-1.8-1.40.4-0.9-2.6-1.2-1.40.8
Condit. Reinf. inactive responses0.60.82.0-0.8-0.3-1.4-0.5-1.0-0.70.9-0.4-1.4-0.6-0.81.0
Incentive salience index mean0.70.92.8-1.0-0.6-1.7-0.8-1.0-0.80.3-0.4-1.7-0.6-0.70.5
Condit. Reinf. lever presses0.30.50.90.60.8-0.10.60.60.71.00.8-0.10.80.70.9
Condit. Reinf. active minus inactive responses0.20.31.0-0.4-0.8-1.0-0.1-0.5-0.5-0.8-0.1-0.7-0.4-0.4-0.3
Condit. Reinf. active-inactive response ratio2.02.33.3-1.7-1.8-1.6-1.3-1.7-1.7-1.4-1.4-1.5-1.6-1.7-0.8
Condit. Reinf. active responses0.10.10.30.3-0.2-0.50.50.20.1-0.30.4-0.20.20.3-0.0
Condit. Reinf. inactive responses0.81.11.81.30.90.81.31.31.10.41.10.91.11.30.2
Condit. Reinf. lever presses0.20.30.60.30.4-0.70.50.30.30.50.6-0.40.40.60.8
Condit. Reinf. lever reinforcers received0.10.10.40.40.0-0.60.60.30.2-0.10.6-0.30.30.40.2
Conditioned reinforcement - actives0.20.41.30.80.60.10.60.80.70.10.60.50.61.10.3
Conditioned reinforcement - inactives0.10.20.5-0.6-0.4-0.6-0.4-0.5-0.4-0.1-0.3-0.7-0.4-0.40.1
Conditioned locomotion0.10.10.20.30.4-0.00.40.30.40.10.40.10.40.50.4
Patch foraging indifference point 0 sec0.10.10.6-0.20.0-0.1-0.4-0.2-0.20.7-0.1-0.3-0.20.20.8
Patch foraging indifference point AUC0.10.10.50.30.3-0.30.30.10.10.70.2-0.20.10.00.7
Delay disc. indifference point, 0s delay0.10.10.50.5-0.10.20.20.40.2-0.70.20.40.10.3-0.6
Delay disc. indifference point, 16s delay2.83.14.92.11.71.02.12.02.00.82.01.31.82.21.1
Delay disc. indifference point, 2s delay0.20.20.70.30.00.80.30.30.2-0.40.10.70.10.1-0.7
Delay disc. indifference point, 24s delay1.72.06.91.20.52.61.11.21.1-1.10.62.50.90.9-1.3
Delay disc. indifference point, 4s delay0.20.20.60.40.10.50.20.60.3-0.60.30.80.30.6-0.4
Delay disc. indifference point, 8s delay0.30.31.10.3-0.31.00.30.30.2-0.70.01.0-0.10.7-0.7
Indifference point function ln k0.61.01.81.00.61.20.91.31.1-0.40.91.31.11.3-0.5
Indifference point function log k0.61.01.81.00.61.20.91.31.1-0.40.91.31.11.3-0.5
Patch foraging total patch changes 0 sec0.10.10.7-0.20.1-0.3-0.3-0.1-0.10.7-0.0-0.3-0.10.30.8
Patch foraging total patch changes 12 sec0.20.20.5-0.5-0.3-0.3-0.6-0.6-0.60.5-0.6-0.4-0.5-0.70.3
Patch foraging total patch changes 18 sec0.40.61.20.90.8-0.10.80.70.70.90.80.10.70.61.1
Patch foraging total patch changes 24 sec0.20.41.0-0.5-0.4-0.9-0.6-0.7-0.60.3-0.4-1.0-0.6-0.50.6
Patch foraging total patch changes 6 sec0.30.51.1-0.8-0.6-0.6-1.0-0.8-0.80.2-0.8-0.7-0.8-0.60.3
Patch foraging time to switch 0 sec0.20.40.80.60.60.90.50.70.60.20.40.80.70.4-0.1
Patch foraging water rate 0 sec0.61.24.1-1.1-0.8-2.0-0.8-1.1-0.90.3-0.4-1.7-1.1-0.30.9
Patch foraging water rate 12 sec0.10.20.80.3-0.2-0.90.60.30.2-0.50.6-0.40.30.3-0.0
Patch foraging water rate 18 sec0.20.31.30.20.1-1.10.50.20.2-0.10.7-0.60.40.30.6
Patch foraging water rate 24 sec0.50.73.7-0.1-0.1-1.90.3-0.3-0.10.10.6-1.60.1-0.11.0
Patch foraging water rate 6 sec0.20.31.10.4-0.5-0.50.60.50.1-1.10.50.10.20.5-0.6
Seeking ratio, delayed vs. immediate footshock0.50.62.0-0.8-0.6-1.4-0.7-0.9-0.70.3-0.4-1.3-0.7-0.60.3
Distance traveled before self-admin1.21.52.4-1.5-1.3-0.7-1.5-1.3-1.4-0.8-1.4-0.9-1.4-1.3-0.8
Distance traveled after self-admin0.60.73.5-0.50.6-0.9-0.3-0.3-0.11.90.0-1.0-0.10.11.7
Extensor digitorum longus weight0.20.81.60.80.9-0.91.10.70.90.81.3-0.21.00.81.1
Bone: elastic displacement1.41.62.5-1.6-1.3-1.2-1.5-1.4-1.4-0.9-1.2-1.2-1.2-1.2-0.6
Bone: elastic work9.512.417.1-4.1-4.1-2.8-3.9-3.9-3.9-3.0-3.6-2.9-3.5-3.7-2.3
Bone: endosteal estimation0.40.92.60.81.3-0.20.90.71.01.61.0-0.00.80.71.2
Bone: endosteal perimeter0.40.81.6-0.9-0.3-1.2-1.0-1.0-0.80.9-0.7-1.1-0.7-0.90.6
Epididymis fat weight0.31.25.3-1.0-0.5-2.3-0.9-0.8-0.70.8-0.2-1.8-0.5-0.11.1
Delta time in closed arm before/after self-admin1.61.53.31.21.3-0.01.21.41.21.11.40.11.21.81.5
Delta time in open arm before/after self-admin0.10.00.40.10.00.40.1-0.00.00.1-0.10.00.1-0.6-0.2
Diff in mean of infusions in LGA sessions0.20.20.7-0.7-0.3-0.2-0.8-0.4-0.50.4-0.7-0.3-0.5-0.20.1
Delay discount exponential model param1.11.32.8-1.3-0.6-1.6-1.1-1.2-1.10.4-0.9-1.7-0.8-1.40.4
Extinction: sum of active levers before priming0.60.72.70.0-0.60.90.1-0.1-0.1-1.6-0.31.00.0-0.9-1.6
Active lever presses in extinction session 63.13.19.6-1.1-2.11.2-1.3-0.9-1.2-3.0-1.61.1-1.3-1.4-3.1
Bone: final force4.16.610.7-2.7-3.2-3.3-2.5-2.6-2.7-2.7-1.9-2.6-2.2-2.3-1.8
Bone: final moment5.28.412.6-3.2-3.5-3.5-2.9-3.0-3.1-2.8-2.4-2.8-2.6-2.7-1.9
Food consumed during 24 hour testing period0.20.30.9-0.50.1-0.7-0.5-0.4-0.30.9-0.2-0.9-0.2-0.10.9
Glucose3.96.121.8-0.1-2.13.6-0.7-0.0-0.8-4.4-1.82.9-0.9-1.0-4.7
Heart weight1.62.54.4-1.5-2.0-1.0-1.3-1.6-1.6-2.0-1.4-0.9-1.4-2.1-1.8
Delay discount hyperbolic model param0.91.02.5-1.1-0.5-1.6-1.0-1.1-1.00.5-0.7-1.6-0.7-1.20.5
Intermittent access intake day 1-15 change0.61.22.4-1.4-0.8-0.7-1.6-1.3-1.21.0-1.3-0.6-1.5-0.70.6
Intermittent access intake escalation0.51.12.0-1.3-0.7-0.7-1.4-1.2-1.11.0-1.2-0.6-1.3-0.60.6
Intermittent access intake escalation 22.62.95.3-2.1-1.6-0.8-2.3-2.0-2.00.2-2.1-1.0-2.3-1.9-0.2
Intermitt. access day 1 inactive lever presses0.41.54.3-1.5-0.2-2.1-0.7-1.0-0.71.3-0.2-2.1-0.70.11.8
Intermitt. access day 15 inactive lever presses0.30.52.0-0.10.5-1.10.2-0.20.11.20.4-1.10.2-0.01.4
Intermitt. access escalation Index0.50.73.00.10.8-0.70.30.10.31.50.5-0.80.20.81.7
Intermittent access day 1 total infusions0.00.10.3-0.1-0.3-0.4-0.1-0.2-0.1-0.6-0.10.0-0.10.1-0.4
Intermittent access day 15 total infusions0.20.40.8-0.7-0.4-0.9-0.8-0.8-0.60.5-0.5-0.4-0.7-0.30.5
Intermittent access terminal intake (last 3 days)0.50.61.1-0.8-0.5-1.0-1.1-1.0-0.90.6-0.8-0.7-1.0-0.50.4
Intermittent access total infusions0.10.10.4-0.3-0.2-0.7-0.4-0.4-0.30.3-0.2-0.2-0.30.30.4
Intermittent access day 1 locomotion0.10.10.80.20.0-0.10.30.40.3-0.30.40.30.30.90.0
Intermittent access day 15 total locomotion0.30.51.0-0.9-0.7-1.0-0.8-0.8-0.7-0.0-0.6-0.5-0.7-0.40.1
Intermittent access total locomotion0.10.10.4-0.5-0.4-0.6-0.4-0.3-0.3-0.0-0.2-0.2-0.30.30.1
Intermittent access standard deviation0.40.91.8-0.8-1.21.0-1.1-0.6-0.7-0.9-1.11.0-1.0-0.1-1.3
Left kidney weight0.31.34.5-0.7-1.6-0.0-0.9-0.6-0.9-2.1-0.80.1-0.5-1.1-2.0
Right kidney weight0.31.25.5-0.3-1.40.2-0.6-0.4-0.6-2.4-0.50.3-0.2-0.9-2.0
Cocaine induced anxiety4.56.49.9-2.9-3.1-0.4-2.6-2.5-2.5-3.1-2.6-0.7-2.6-2.4-3.1
Post-drug Anxiety3.63.89.1-2.0-2.50.7-1.8-1.6-1.7-2.7-2.00.1-1.8-1.7-3.0
Baseline Anxiety1.11.32.31.41.11.51.11.21.10.80.91.11.11.10.5
Tail length1.76.817.5-3.1-1.4-4.2-2.6-2.8-2.41.5-1.8-3.8-2.3-1.62.0
Length with tail1.56.510.9-3.3-2.8-2.7-3.2-2.8-2.8-1.2-2.5-2.4-2.8-1.9-0.8
Length without tail1.85.713.6-2.0-3.2-0.2-2.3-1.8-2.3-3.7-2.4-0.2-2.3-2.0-3.4
Times rat made contact with spout2.12.44.1-1.9-0.8-0.9-1.8-2.0-1.70.8-1.8-1.4-1.7-1.90.7
Lifetime Intake0.00.00.3-0.1-0.0-0.2-0.1-0.1-0.00.30.00.2-0.10.50.3
Liver weight, left0.40.61.70.2-0.11.2-0.10.80.4-1.10.11.30.40.8-1.1
Liver weight, right0.71.34.0-1.4-0.5-2.0-1.3-1.0-0.80.5-0.4-1.9-0.5-0.61.0
Locomotor activity0.40.61.91.00.51.40.70.90.7-0.10.51.00.70.5-0.1
Locomotor testing distance1.42.43.91.91.51.91.62.01.70.31.41.61.71.70.4
Locomotor testing rearing0.71.52.21.31.50.91.31.31.21.41.10.61.21.31.3
Locomotion in novel chamber0.50.71.21.00.80.71.10.90.90.30.90.60.81.00.3
Locomotion in novel chamber post-restriction1.93.16.0-2.2-0.8-2.4-1.7-2.1-1.61.5-1.2-2.5-1.8-1.11.6
Fecal boli incidents, locomotor time 10.40.61.10.91.00.50.90.90.90.50.90.61.00.60.6
Change in fecal boli incidents, locomotor task0.60.62.40.0-0.61.6-0.5-0.0-0.3-0.6-0.81.0-0.6-0.2-1.3
Time >=10cm from walls, locomotor time 11.01.03.90.30.9-1.10.50.10.52.00.8-0.90.40.72.0
Bouts of movement, locomotor time 10.60.72.20.70.41.40.60.80.7-0.90.41.50.80.4-0.8
Total resting periods, locomotor time 10.70.82.60.60.41.60.50.80.6-0.90.31.60.70.4-0.8
Rest time, locomotor task time 10.20.30.9-0.5-0.31.0-0.5-0.2-0.3-0.6-0.60.5-0.2-0.6-0.8
Distance moved, locomotor task time 10.10.20.70.1-0.1-0.9-0.00.0-0.00.50.2-0.4-0.20.80.5
Vertical activity count, locomotor time 10.10.31.50.10.1-1.20.2-0.10.00.60.4-0.9-0.10.40.8
Time >=10cm from walls, locomotor time 20.10.10.60.1-0.4-0.2-0.0-0.3-0.2-0.8-0.10.0-0.2-0.4-0.7
Bouts of movement, locomotor time 20.61.03.20.80.70.91.01.11.1-0.11.01.10.91.8-0.1
Total resting periods, locomotor time 20.71.13.80.91.00.61.21.21.20.41.20.81.12.00.5
Rest time, locomotor task time 20.20.31.6-0.10.70.10.10.20.31.30.1-0.00.10.61.1
Distance moved, locomotor task time 20.30.31.60.5-0.4-0.00.10.30.0-1.30.10.5-0.00.2-1.1
Vertical activity count, locomotor time 20.20.30.80.8-0.0-0.20.70.60.4-0.90.70.10.50.3-0.5
Light reinforcement 10.41.13.60.00.9-1.50.4-0.10.31.70.7-1.60.30.31.9
Light reinforcement 20.60.93.2-0.9-0.1-1.8-0.5-0.8-0.50.8-0.1-1.8-0.5-0.31.0
Bone: marrow area0.40.92.40.81.3-0.30.90.70.91.61.00.00.80.71.2
Bone: maximum diameter0.91.72.7-1.3-1.6-1.6-1.4-1.3-1.4-1.3-1.1-1.1-1.1-1.2-1.0
Bone: maximum force3.66.411.8-2.7-3.1-3.4-2.3-2.6-2.6-2.5-1.8-2.7-2.1-2.3-1.6
Bone: maximum moment4.68.112.8-3.1-3.4-3.6-2.8-3.0-3.0-2.6-2.2-2.9-2.5-2.7-1.7
Mean time between licks in bursts0.61.42.31.31.01.41.21.51.3-0.11.11.51.21.3-0.3
Mean num. licks in bursts0.71.22.1-1.2-0.9-0.3-1.2-1.4-1.3-0.1-1.5-0.8-1.5-1.3-0.2
Cd content in liver1.21.32.11.31.30.21.41.21.31.11.40.61.21.00.9
Co content in liver0.10.10.4-0.10.30.1-0.3-0.2-0.00.6-0.1-0.20.0-0.20.5
Cu content in liver1.21.52.8-1.7-1.2-0.8-1.7-1.4-1.4-0.2-1.5-1.0-1.2-1.1-0.2
Fe content in liver0.81.01.91.11.10.80.91.21.10.71.00.81.01.40.6
K content in liver1.51.55.50.01.2-1.20.30.30.62.30.9-1.20.71.02.3
Mg content in liver2.82.97.81.12.1-0.71.41.11.52.81.8-0.61.51.62.7
Mn content in liver0.00.00.1-0.1-0.2-0.3-0.00.0-0.1-0.40.1-0.10.2-0.0-0.2
Na content in liver0.60.61.20.61.00.10.60.80.81.10.80.10.71.10.9
Rb content in liver0.70.83.1-0.10.3-1.80.1-0.4-0.11.10.4-1.60.1-0.31.4
Se content in liver0.30.31.4-0.20.4-0.6-0.1-0.3-0.01.10.1-0.8-0.1-0.11.2
Sr content in liver0.90.81.4-0.6-1.00.6-0.8-0.7-0.8-1.2-1.10.3-1.0-0.8-1.2
Zn content in liver0.90.92.6-1.00.1-1.6-0.5-0.8-0.51.5-0.2-1.5-0.4-0.41.4
Bone: minimum diameter2.13.96.2-2.4-2.0-2.4-2.5-2.2-2.1-0.7-1.8-2.2-1.8-2.0-0.4
Time in familiar zone, hab. session 10.40.40.9-0.5-0.70.1-0.3-0.5-0.6-0.9-0.6-0.1-0.5-0.8-1.0
Time in novel zone, hab. session 10.20.20.50.40.5-0.10.30.40.40.60.40.10.30.50.7
Total zone transitions, hab. session 10.30.50.80.80.30.50.90.80.6-0.70.70.80.80.5-0.5
Total locomotion distance, hab. session 10.10.10.30.40.2-0.20.50.40.4-0.30.5-0.00.60.20.0
Locomotion velocity, hab. session 10.10.10.40.50.3-0.20.40.40.4-0.20.6-0.00.60.20.1
Time in familiar zone, hab. session 20.30.30.40.70.60.50.60.50.60.30.60.60.60.20.1
Time in novel zone, hab. session 20.10.10.30.1-0.20.00.20.20.0-0.50.10.20.00.3-0.3
Total zone transitions, hab. session 21.51.93.21.61.4-0.11.71.51.50.81.80.41.71.61.2
Total locomotion distance, hab. session 21.01.32.41.01.2-0.91.20.91.11.11.5-0.51.21.01.5
Locomotion velocity, hab. session 20.71.02.20.81.0-1.11.00.70.81.01.3-0.71.00.81.5
Novel to familiar place preference ratio3.43.85.4-2.3-2.2-1.7-2.2-2.2-2.2-1.3-2.1-1.7-2.1-1.8-0.8
Novelty place preference3.53.85.4-2.3-2.2-1.6-2.2-2.2-2.2-1.3-2.1-1.7-2.2-1.9-0.9
Time in novel zone, NPP test2.72.94.2-2.0-2.0-1.5-1.9-2.0-2.0-1.2-1.8-1.5-1.9-1.6-0.7
Total zone transitions, NPP test2.53.75.72.12.10.22.22.12.11.52.40.72.22.21.7
Total locomotion distance, NPP test2.02.74.51.71.9-0.41.81.61.71.52.1-0.11.91.71.9
Locomotion velocity, NPP test1.11.62.81.31.4-0.61.31.11.31.31.6-0.31.41.31.7
Intraocular pressure0.40.62.3-0.6-0.0-1.5-0.3-0.6-0.41.1-0.1-1.2-0.5-0.31.2
Delta distance traveled before/after self-admin1.21.33.11.01.40.41.01.01.11.81.00.31.01.01.6
Delta ambulatory time before/after self-admin2.32.94.91.72.10.81.71.71.72.21.60.81.71.72.0
Parametrial fat weight0.20.52.0-0.60.2-1.4-0.2-0.5-0.20.90.1-1.3-0.10.01.1
Pavlov. Cond. lever latency2.02.53.81.91.80.61.91.81.81.11.90.91.71.61.1
Pavlov. Cond. magazine entry latency3.34.26.6-2.6-2.3-1.4-2.4-2.4-2.4-1.2-2.3-1.6-2.3-1.9-0.9
Pavlov. Cond. change in total contacts1.92.02.9-1.5-1.7-0.1-1.7-1.4-1.5-1.6-1.7-0.4-1.4-1.4-1.4
Pavlov. Cond. index score3.24.06.5-2.5-2.1-1.7-2.4-2.4-2.3-0.8-2.2-1.9-2.2-1.9-0.4
Pavlov. Cond. latency score3.03.86.0-2.4-2.1-1.4-2.3-2.3-2.3-0.9-2.2-1.7-2.1-1.9-0.6
Pavlov. Cond. lever contacts0.91.11.8-1.3-1.1-0.6-1.3-1.2-1.2-0.5-1.2-0.8-1.1-0.9-0.4
Pavlov. Cond. magazine entry number4.76.08.93.02.81.32.82.82.81.72.91.62.72.51.4
Pavlov. Cond. intertrial magazine entries0.40.41.10.40.7-0.80.60.20.51.00.8-0.60.40.21.0
Pavlov. Cond. lever-magazine prob. diff.3.13.86.2-2.5-2.1-1.7-2.3-2.3-2.2-0.9-2.1-1.8-2.1-1.8-0.5
Pavlov. Cond. response bias3.44.26.3-2.5-2.4-1.1-2.4-2.3-2.4-1.5-2.4-1.3-2.3-2.0-1.3
Pavlov. Cond. lever latency0.50.72.4-0.1-0.61.3-0.40.0-0.2-1.3-0.51.2-0.2-0.2-1.5
Pavlov. Cond. magazine entry latency2.53.04.32.01.91.11.92.12.01.01.91.42.11.90.9
Pavlov. Cond. change in total contacts0.50.81.31.11.00.11.10.90.90.81.00.30.90.90.9
Pavlov. Cond. index score0.60.81.10.91.0-0.01.00.90.90.81.00.21.01.01.0
Pavlov. Cond. latency score0.71.01.51.01.2-0.01.11.01.01.01.20.21.21.01.2
Pavlov. Cond. lever contacts0.50.72.40.30.8-1.10.50.10.31.30.6-1.00.40.31.6
Pavlov. Cond. magazine entry number1.82.33.7-1.7-1.6-0.9-1.6-1.8-1.7-0.9-1.6-1.1-1.7-1.9-0.9
Pavlov. Cond. intertrial magazine entries0.71.03.2-1.0-0.7-1.8-0.6-1.2-0.90.1-0.5-1.6-1.0-0.90.5
Pavlov. Cond. lever-magazine prob. diff.0.70.91.31.11.10.21.11.11.00.81.10.51.11.10.9
Pavlov. Cond. response bias0.40.61.00.80.9-0.30.90.70.70.90.9-0.10.70.81.0
Time in closed arm before self-admin0.60.72.2-0.6-1.00.7-0.6-0.5-0.6-1.4-0.80.6-0.7-0.6-1.5
Time in closed arm after self-admin0.20.30.9-0.1-0.31.0-0.20.2-0.0-0.5-0.30.7-0.50.8-0.5
Time in open arm before self-admin0.90.91.61.11.2-0.31.00.91.00.91.10.11.10.81.3
Time in open arm after self-admin0.20.20.60.70.5-0.00.70.50.50.20.60.00.8-0.10.2
Bone: periosteal estimation0.81.73.8-1.4-1.4-2.0-1.3-1.3-1.3-0.9-0.9-1.5-1.1-1.3-0.7
Bone: periosteal perimeter4.17.09.8-3.0-3.1-2.2-3.0-2.9-3.0-2.2-2.8-2.0-2.7-2.8-1.8
Bone: post-yield work0.10.10.40.50.2-0.10.70.40.4-0.00.60.20.40.30.1
Progressive ratio test 1 active lever presses0.10.20.5-0.3-0.1-0.7-0.4-0.2-0.20.5-0.1-0.3-0.30.60.7
Progressive ratio test 1 breakpoint0.20.20.7-0.4-0.2-0.8-0.5-0.3-0.30.5-0.1-0.4-0.40.50.7
Progressive ratio test 1 inactive lever presses0.91.34.7-0.9-0.1-2.2-0.6-0.8-0.51.3-0.1-1.8-0.5-0.01.8
Progressive ratio test 2 active lever presses0.10.20.6-0.3-0.0-0.8-0.2-0.3-0.20.5-0.0-0.5-0.2-0.00.7
Progressive ratio test 2 breakpoint0.10.20.6-0.4-0.1-0.8-0.3-0.3-0.20.5-0.1-0.5-0.3-0.00.6
Progressive ratio test 2 inactive lever presses0.20.30.6-0.6-0.7-0.5-0.8-0.6-0.7-0.3-0.6-0.3-0.7-0.4-0.2
Incentive Sensitization - Responses0.20.20.6-0.30.1-0.7-0.2-0.3-0.20.7-0.1-0.8-0.2-0.50.8
Incentive Sensitization - Breakpoint0.20.20.5-0.30.1-0.6-0.2-0.3-0.30.5-0.1-0.7-0.2-0.60.7
Sum of active levers in priming session hrs 5-62.12.03.1-1.5-1.7-0.4-1.6-1.5-1.5-1.3-1.6-0.6-1.6-1.8-1.2
Progressive ratio0.40.61.30.90.31.00.70.90.7-0.70.61.20.70.7-0.7
Food seeking constrained by brief footshock0.30.30.7-0.7-0.40.5-0.6-0.7-0.5-0.4-0.80.3-0.7-0.4-0.7
Seeking ratio, punishment vs. effort0.10.10.3-0.40.2-0.4-0.1-0.4-0.10.5-0.1-0.5-0.1-0.10.4
Retroperitoneal fat weight1.14.515.4-2.1-0.6-3.9-1.7-2.1-1.41.7-0.7-3.7-1.3-1.02.2
Reaction time number correct2.44.57.42.22.4-0.72.62.12.22.22.7-0.32.22.12.4
Reaction time mean minus median0.10.20.5-0.3-0.30.7-0.4-0.5-0.40.1-0.70.3-0.6-0.7-0.5
Reaction time mean minus median AUC0.00.00.2-0.2-0.10.2-0.0-0.2-0.20.2-0.30.0-0.3-0.4-0.2
Reaction time num false alarms0.10.10.30.30.30.50.10.20.30.10.10.40.4-0.00.0
Reaction time num false alarms AUC0.30.40.70.80.80.80.60.70.70.30.60.80.80.40.2
Reaction time trials correct on left2.44.57.42.22.4-0.72.62.12.22.22.7-0.32.22.12.4
Reaction time trials on left2.54.77.62.22.5-0.72.62.12.22.22.8-0.32.32.22.5
Reaction time mean0.10.20.6-0.3-0.2-0.5-0.1-0.6-0.30.3-0.3-0.6-0.4-0.80.0
Reaction time mean AUC0.10.10.40.10.3-0.50.4-0.10.10.60.2-0.50.1-0.30.4
Median of all reaction times0.10.10.5-0.1-0.1-0.70.1-0.4-0.20.30.0-0.7-0.1-0.50.1
Reaction time omissions0.10.21.00.30.4-0.20.10.10.21.00.3-0.30.20.10.7
Reaction time false alarm rate0.40.51.1-0.4-0.51.1-0.8-0.5-0.5-0.8-0.90.8-0.4-0.8-1.0
Reaction time premature initiation rate0.50.72.31.00.71.50.80.90.80.20.61.10.80.6-0.0
Reaction time premature initiations1.62.94.42.01.90.92.11.91.91.42.00.71.91.71.4
Std. dev. reaction times0.10.20.50.60.50.70.60.30.40.60.20.50.3-0.1-0.1
Reaction time trials completed2.54.77.62.22.5-0.72.62.12.22.22.8-0.32.32.22.5
Reaction time trials AUC2.44.57.42.22.4-0.72.62.12.22.22.7-0.42.22.12.4
Run reversals in cocaine runway, females0.90.91.81.31.20.91.31.01.10.41.10.41.10.50.4
Run reversals in cocaine runway, males2.22.23.4-1.8-1.4-0.9-1.8-1.7-1.7-0.3-1.7-1.1-1.8-1.8-0.3
Latency to leave start box in cocaine runway0.50.61.00.91.00.50.80.90.90.60.90.41.00.80.6
Latency to leave start box in cocaine runway, F1.92.23.61.71.90.21.71.51.61.31.80.51.91.21.4
Latency to leave start box in cocaine runway, M0.20.20.4-0.5-0.60.2-0.6-0.3-0.5-0.4-0.6-0.1-0.6-0.1-0.6
Std. dev. time between licks in bursts1.62.23.81.21.6-1.01.71.21.51.71.9-0.51.41.61.9
Total sessions with >9 infusions0.30.41.30.70.30.80.40.60.60.10.41.10.50.90.1
Short access day 1 total inactive lever presses0.40.51.20.70.5-0.00.80.70.8-0.11.00.30.91.10.4
Short access day 10 total inactive lever presses0.71.65.8-1.4-0.6-2.2-1.0-1.3-1.00.6-0.4-2.4-0.9-0.41.2
Short access day 1 total infusions1.01.33.01.40.71.51.11.21.1-0.40.91.71.21.2-0.5
Short access day 10 total infusions0.81.01.9-1.4-0.7-1.1-1.2-1.3-1.00.6-0.9-0.9-1.2-0.40.5
Short access total infusions0.00.10.30.00.00.3-0.00.00.10.20.10.50.00.50.1
Short access day 1 locomotion0.30.41.30.0-0.60.7-0.2-0.0-0.2-1.0-0.30.9-0.1-0.1-1.2
Short access day 10 total locomotion0.50.92.0-0.7-1.10.7-1.0-0.6-0.8-1.4-1.00.4-1.0-0.5-1.4
Short access total locomotion0.50.61.2-0.6-1.00.4-0.9-0.6-0.6-1.1-0.80.7-0.8-0.3-1.1
One hour access (0.3 mA shock)0.10.10.9-0.10.3-0.9-0.1-0.2-0.00.40.1-0.50.0-0.10.6
Compulsive drug intake0.40.51.70.00.7-1.10.40.10.30.70.6-1.00.40.61.3
One hour access (shock baseline)0.10.10.40.20.3-0.30.00.10.10.60.20.10.10.40.5
Social response proportion0.50.61.40.90.50.60.91.00.80.30.90.80.81.20.1
Social responses0.50.72.00.70.60.50.61.00.90.20.90.91.01.40.3
Social time0.20.30.70.50.10.40.50.70.5-0.60.60.50.90.5-0.4
Soleus weight0.72.05.1-1.6-0.8-2.3-1.3-1.7-1.30.6-1.0-2.0-1.3-1.21.0
Bone: stiffness0.60.94.1-0.5-1.4-1.2-0.4-0.4-0.6-2.0-0.1-0.4-0.3-0.5-1.5
Tibialis anterior weight0.10.20.60.30.6-0.40.60.30.40.60.6-0.10.50.30.8
Time to tail flick, vehicle, before self-admin0.10.10.20.40.40.40.40.20.30.10.20.50.3-0.10.2
Time to tail flick, vehicle, after self-admin1.41.92.91.51.01.61.41.71.4-0.51.31.61.51.6-0.3
Time to tail flick, test, before self-admin0.10.10.8-0.20.10.2-0.00.10.10.70.00.1-0.10.90.3
Time to tail flick, test, after self-admin0.30.41.50.1-0.21.20.00.40.2-0.4-0.11.1-0.10.8-0.7
Delta time to tail flick, vehicle, before/after SA0.60.61.10.70.80.10.70.90.80.50.90.00.91.00.7
Delta time to tail flick, test, before/after SA0.70.73.00.1-0.81.0-0.20.0-0.3-1.6-0.50.9-0.3-0.5-1.7
Tibia length8.523.532.1-5.7-5.5-5.3-5.0-5.4-5.4-3.6-4.6-4.7-4.9-4.8-2.2
Ambulatory time before self-admin1.92.84.4-2.1-1.8-1.5-1.9-1.9-1.9-0.9-1.7-1.5-1.8-1.8-0.8
Ambulatory time after self-admin0.20.31.1-0.40.2-0.6-0.3-0.3-0.21.1-0.1-0.6-0.1-0.30.9
Bone: tissue strength0.60.63.1-0.8-0.7-1.8-0.6-0.7-0.6-0.4-0.2-1.3-0.3-0.50.0
Total heroin consumption1.51.74.4-1.1-1.60.6-1.0-0.9-1.0-2.1-1.20.4-1.1-1.2-2.1
Bone: trabecular number0.00.00.1-0.10.1-0.1-0.1-0.2-0.20.2-0.2-0.3-0.2-0.20.4
Bone: trabecular spacing1.62.13.61.31.6-0.71.41.31.51.61.9-0.21.61.61.7
Bone: trabecular thickness2.43.04.8-2.1-1.8-0.5-2.0-2.0-2.0-1.2-2.1-0.9-1.9-2.2-1.0
Bone: trabecular tissue density0.50.81.61.10.71.01.11.11.0-0.10.81.30.90.8-0.3
Water consumed over 24 hours0.20.30.8-0.7-0.40.4-0.8-0.5-0.6-0.1-0.90.1-0.5-0.6-0.2
Number of responses in last shaping day0.20.30.70.4-0.30.40.10.50.2-0.90.20.80.30.6-0.8