Cd248

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Cd248	0.03	0.02	2.2e-03	0.03	0.01	0	0.02	6.2e-04	1.8e-02	2.4e-01	3.9e-03
2	pVTA	gene expression	Cd248	0.04	0.03	2.5e-03	0.04	0.04	0.03	0.04	4.6e-04	6.4e-04	9.0e-04	7.2e-04
3	Brain	gene expression	Cd248	0.12	0.07	2.4e-08	0.09	0.08	0.08	0.09	1.2e-08	7.7e-08	5.3e-08	1.9e-08
4	BLA	gene expression	Cd248	0.07	0.05	3.2e-03	0.03	0.02	0	0.01	1.4e-02	2.2e-02	2.4e-01	6.9e-02
5	PL	gene expression	Cd248	0.09	0.06	2.9e-06	0.05	0.05	0.05	0.05	1.7e-06	1.8e-06	1.7e-06	1.7e-06
6	NAcc	gene expression	Cd248	0.02	0.02	7.3e-04	0.02	0.02	0.01	0.01	1.1e-03	1.1e-03	2.6e-03	2.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.8	1.4	2.6	0.6	1.3	1.2	0.8	-1.3	-1.6
Area under the delay curve	0.6	1.0	1.5	1.0	0.7	1.2	0.4	-1.2	-1.1
BMI with tail	0.6	2.2	3.6	1.4	1.2	1.1	1.6	-1.6	-1.9
BMI without tail	0.2	0.9	1.3	1.1	0.2	0.9	0.9	-1.1	-1.1
Body weight	0.3	1.2	2.5	-1.0	-1.6	-1.1	-1.1	0.9	0.7
Weight adjusted by age	0.7	2.1	2.5	-1.6	-1.2	-1.6	-1.6	1.5	1.3
Bone surface	0.3	0.5	2.0	-1.4	0.1	-0.4	-0.7	0.5	-0.3
Bone volume	0.2	0.3	0.8	-0.3	0.8	0.3	0.4	-0.3	-0.9
Breakpoint value in progressive ratio session	0.8	1.5	2.0	-1.4	-0.9	-1.4	-1.1	1.4	0.9
Number of licking bursts	0.1	0.2	0.4	-0.5	-0.3	-0.6	-0.4	0.4	0.2
Context. condit. distance diff. score	1.1	1.4	2.1	1.4	1.2	1.1	1.1	-1.2	-0.9
Locomotion velocity, session 1	0.3	0.3	0.7	-0.2	-0.8	-0.3	-0.7	0.4	0.5
Locomotion distance, session 1	0.3	0.4	0.8	0.6	0.4	0.6	0.2	-0.9	-0.9
Locomotion velocity, session 2	0.4	0.5	1.0	-0.6	-1.0	-0.8	-0.6	0.7	0.5
Locomotion distance, session 2	0.1	0.1	0.2	0.3	-0.2	0.5	0.0	-0.5	-0.4
Locomotion velocity, session 3	0.6	0.7	1.1	1.1	0.7	0.8	0.7	-1.0	-0.9
Locomotion distance, session 3	0.0	0.0	0.0	0.1	0.0	0.1	-0.1	-0.1	-0.1
Stereotopy head waving bouts, day 3	1.6	1.9	2.5	1.5	1.1	1.5	1.0	-1.6	-1.3
Stereotopy head waving duration, day 3	1.6	1.9	2.3	1.3	1.4	1.5	1.1	-1.5	-1.4
Locomotion velocity, session 7	1.8	2.0	3.3	1.8	1.1	1.1	1.8	-1.3	-1.2
Locomotion distance, session 7	0.3	0.4	1.0	1.0	0.1	0.6	0.5	-0.9	-0.5
Stereotopy head waving bouts, day 7	0.6	0.7	1.7	0.5	1.3	0.6	0.9	-0.6	-0.9
Stereotopy head waving duration, day 7	0.2	0.2	0.8	-0.0	0.9	0.1	0.4	-0.2	-0.6
Locomotion velocity, session 8	1.0	1.2	2.7	-1.1	-1.1	-0.8	-1.6	0.8	0.9
Locomotion distance, session 8	0.6	0.8	1.4	1.2	0.8	0.8	1.0	-0.9	-0.8
Degree of sensitization distance	0.4	0.5	0.7	0.9	0.4	0.6	0.7	-0.9	-0.7
Degree of sensitization stereotypy	0.1	0.1	0.4	-0.3	0.6	-0.3	0.4	0.2	-0.2
Conditioned locomotion	1.4	1.6	2.5	-1.1	-1.6	-1.1	-1.3	1.3	1.3
Cocaine response after cond. corrected	0.3	0.5	1.4	1.2	0.4	0.7	0.5	-0.7	-0.4
Cocaine response after cond. not corrected	0.3	0.4	0.8	0.9	0.6	0.6	0.5	-0.6	-0.5
Cocaine response before conditioning	0.2	0.3	0.9	-0.9	-0.1	-0.7	-0.1	0.6	0.2
Saline control response	1.4	2.0	3.3	-1.8	-1.3	-1.2	-1.8	1.2	0.9
Bone: connectivity density	0.2	0.3	0.9	-0.4	0.5	0.4	-0.1	-0.5	-0.9
Bone: cortical apparent density	0.3	0.5	0.7	-0.5	-0.9	-0.7	-0.6	0.8	0.8
Bone: cortical area	0.7	1.1	1.8	-1.0	-1.0	-1.2	-0.7	1.3	1.1
Bone: cortical porosity	0.2	0.2	0.5	0.3	0.4	0.6	0.2	-0.7	-0.6
Bone: cortical porosity	0.1	0.1	0.2	-0.0	0.0	0.4	-0.1	-0.4	-0.3
Bone: cortical thickness	4.8	8.0	9.2	-2.4	-3.0	-3.0	-2.5	2.9	3.0
Bone: cortical thickness	1.8	2.2	3.9	-1.1	-2.0	-1.4	-1.6	1.2	1.6
Bone: cortical tissue density	0.5	0.8	1.0	-0.7	-1.0	-0.8	-0.8	0.9	1.0
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.3	0.0	-0.1	0.3	-0.0	-0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.3	0.2	-0.0	0.3	0.0	-0.2
Condit. Reinf. active responses	0.1	0.1	0.5	0.5	-0.0	-0.1	0.7	-0.0	-0.1
Condit. Reinf. inactive responses	0.2	0.3	0.8	0.6	0.2	0.2	0.9	-0.3	-0.3
Incentive salience index mean	0.1	0.1	0.3	0.5	0.1	0.0	0.6	-0.2	-0.3
Condit. Reinf. lever presses	0.1	0.1	0.3	0.0	-0.2	-0.5	0.4	0.4	0.3
Condit. Reinf. active minus inactive responses	0.4	0.6	1.8	0.0	1.3	0.5	0.7	-0.6	-0.9
Condit. Reinf. active-inactive response ratio	0.7	1.1	2.2	0.6	1.5	0.7	1.4	-0.7	-1.0
Condit. Reinf. active responses	0.5	0.8	1.9	-0.0	1.4	0.6	0.4	-0.9	-1.2
Condit. Reinf. inactive responses	0.2	0.4	0.7	-0.1	0.6	0.6	-0.4	-0.9	-0.8
Condit. Reinf. lever presses	0.3	0.5	1.4	-1.2	0.0	-0.8	-0.6	0.6	0.2
Condit. Reinf. lever reinforcers received	0.3	0.5	1.3	-0.4	1.1	0.3	0.1	-0.7	-0.9
Conditioned reinforcement - actives	0.1	0.3	0.6	-0.8	-0.2	-0.7	-0.2	0.7	0.5
Conditioned reinforcement - inactives	0.4	1.2	2.6	0.7	1.6	1.1	1.2	-0.7	-0.9
Conditioned locomotion	1.7	2.6	3.4	1.7	1.8	1.6	1.8	-1.5	-1.3
Patch foraging indifference point 0 sec	0.1	0.3	0.4	0.3	0.6	0.4	0.5	-0.5	-0.6
Patch foraging indifference point AUC	1.0	2.3	3.6	-1.9	-1.1	-1.7	-1.2	1.7	1.4
Delay disc. indifference point, 0s delay	2.1	2.3	3.3	1.7	1.0	1.8	1.1	-1.8	-1.5
Delay disc. indifference point, 16s delay	0.8	1.2	2.0	0.9	1.4	1.1	0.9	-1.0	-1.2
Delay disc. indifference point, 2s delay	0.4	0.5	0.6	0.7	0.6	0.7	0.5	-0.8	-0.8
Delay disc. indifference point, 24s delay	0.1	0.2	0.6	-0.1	-0.5	0.1	-0.8	-0.1	0.2
Delay disc. indifference point, 4s delay	0.8	0.9	1.7	1.0	0.4	1.3	0.2	-1.3	-1.0
Delay disc. indifference point, 8s delay	0.4	0.6	1.1	0.8	0.4	1.1	0.1	-1.0	-0.8
Indifference point function ln k	1.4	4.3	8.1	2.8	1.5	2.3	1.8	-2.0	-1.6
Indifference point function log k	1.4	4.3	8.1	2.8	1.5	2.3	1.8	-2.0	-1.6
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	-0.0	-0.1	-0.0	-0.1	-0.0	-0.1
Patch foraging total patch changes 12 sec	1.2	1.6	2.4	-1.6	-1.0	-1.5	-1.3	1.1	0.9
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.4	0.1	-0.4	0.0	0.0	-0.0
Patch foraging total patch changes 24 sec	0.6	2.2	3.4	-1.8	-1.3	-1.6	-1.4	1.3	1.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.5	-0.7	-0.3	-0.6	-0.4	0.5	0.2
Patch foraging time to switch 0 sec	0.1	0.4	0.7	0.3	0.5	0.4	0.8	-0.6	-0.8
Patch foraging water rate 0 sec	0.0	0.1	0.2	0.4	0.1	0.2	-0.0	0.2	0.4
Patch foraging water rate 12 sec	0.2	0.8	1.9	1.3	0.5	1.4	0.0	-1.0	-0.3
Patch foraging water rate 18 sec	0.2	0.5	1.5	1.2	0.2	0.9	0.3	-0.7	-0.3
Patch foraging water rate 24 sec	0.1	0.2	0.6	0.8	0.2	0.7	0.2	-0.2	0.1
Patch foraging water rate 6 sec	0.1	0.2	0.4	0.7	-0.3	0.5	-0.5	-0.2	0.3
Seeking ratio, delayed vs. immediate footshock	0.6	0.9	1.2	0.9	0.9	1.0	0.7	-1.1	-1.1
Distance traveled before self-admin	0.0	0.1	0.2	-0.2	0.3	-0.1	0.5	0.0	-0.3
Distance traveled after self-admin	0.1	0.1	0.3	-0.5	-0.1	-0.4	0.4	0.3	0.1
Extensor digitorum longus weight	3.3	13.2	17.0	-3.4	-4.1	-3.9	-3.1	3.7	3.4
Bone: elastic displacement	0.6	0.8	1.5	-0.3	-1.2	-0.6	-0.9	0.9	1.2
Bone: elastic work	2.2	2.9	4.5	-1.2	-2.1	-1.5	-1.7	1.7	1.8
Bone: endosteal estimation	1.9	4.7	6.1	1.8	2.2	2.5	2.1	-2.1	-2.3
Bone: endosteal perimeter	2.5	6.2	8.5	1.9	2.9	2.5	2.5	-2.2	-2.8
Epididymis fat weight	1.1	5.5	7.8	2.3	2.8	2.2	2.8	-1.9	-1.9
Delta time in closed arm before/after self-admin	0.4	0.3	0.9	-0.1	-0.9	-0.2	-1.0	0.1	0.5
Delta time in open arm before/after self-admin	0.2	0.2	0.6	-0.8	0.0	-0.5	0.4	0.7	0.3
Diff in mean of infusions in LGA sessions	0.4	0.7	0.9	-0.9	-0.7	-0.9	-0.6	0.9	0.8
Delay discount exponential model param	0.4	0.6	1.0	-0.7	-0.5	-1.0	-0.2	1.0	0.9
Extinction: sum of active levers before priming	0.1	0.2	0.3	-0.5	-0.2	-0.6	-0.3	0.6	0.1
Active lever presses in extinction session 6	2.1	2.1	3.0	-1.6	-1.2	-1.7	-1.1	1.6	1.3
Bone: final force	0.8	1.3	1.9	-1.4	-1.1	-1.0	-1.2	1.3	0.9
Bone: final moment	0.8	1.2	1.8	-1.3	-1.1	-1.0	-1.2	1.2	0.8
Food consumed during 24 hour testing period	0.3	0.6	1.0	-1.0	-0.3	-0.8	-0.7	1.0	0.7
Glucose	4.8	7.5	9.0	2.8	2.6	3.0	2.5	-2.8	-2.7
Heart weight	3.8	6.2	8.1	2.7	2.1	2.7	1.9	-2.8	-2.5
Delay discount hyperbolic model param	0.5	0.7	1.1	-0.8	-0.5	-1.0	-0.3	1.1	1.0
Intermittent access intake day 1-15 change	0.0	0.2	0.6	0.2	0.8	0.2	0.7	0.0	-0.1
Intermittent access intake escalation	0.0	0.1	0.3	-0.0	0.6	-0.1	0.6	0.4	0.1
Intermittent access intake escalation 2	0.1	0.1	0.5	0.0	0.5	0.0	0.7	0.3	0.1
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.2	0.0	0.4	0.0	0.3	0.1	-0.0
Intermitt. access day 15 inactive lever presses	0.3	1.5	2.6	1.0	1.5	1.0	1.6	-0.9	-1.1
Intermitt. access escalation Index	1.2	3.6	4.7	2.1	1.7	2.2	1.6	-2.1	-1.7
Intermittent access day 1 total infusions	2.9	8.6	8.8	2.9	3.0	3.0	2.9	-2.9	-2.9
Intermittent access day 15 total infusions	1.9	4.7	6.6	2.0	2.6	2.0	2.6	-1.8	-1.9
Intermittent access terminal intake (last 3 days)	3.1	5.4	7.6	2.1	2.7	2.1	2.8	-2.0	-2.1
Intermittent access total infusions	5.0	6.0	7.2	2.4	2.7	2.3	2.7	-2.3	-2.3
Intermittent access day 1 locomotion	2.9	5.3	5.6	2.3	2.2	2.2	2.3	-2.4	-2.3
Intermittent access day 15 total locomotion	1.2	4.6	6.9	1.9	2.6	1.8	2.5	-1.9	-2.0
Intermittent access total locomotion	7.9	9.4	12.2	2.9	3.5	2.8	3.5	-2.8	-2.9
Intermittent access standard deviation	0.1	0.3	0.6	0.6	0.6	0.4	0.8	-0.5	-0.3
Left kidney weight	0.4	3.0	5.9	2.2	1.4	1.6	2.4	-1.3	-1.2
Right kidney weight	0.0	0.3	0.8	0.8	0.4	0.5	0.9	-0.2	-0.1
Cocaine induced anxiety	0.0	0.0	0.1	-0.1	0.1	-0.2	0.4	0.1	0.1
Post-drug Anxiety	0.5	0.5	1.1	-1.1	-0.4	-0.8	-0.6	0.7	0.6
Baseline Anxiety	0.4	0.7	1.9	-1.0	-0.7	-0.6	-1.4	0.6	0.6
Tail length	0.6	3.4	5.7	-1.5	-2.4	-1.4	-1.9	1.8	1.9
Length with tail	1.9	8.3	10.8	-2.7	-3.3	-2.6	-3.0	2.8	2.8
Length without tail	1.4	7.1	9.7	-2.7	-2.8	-2.4	-3.1	2.4	2.4
Times rat made contact with spout	0.1	0.1	0.4	-0.2	-0.3	0.1	-0.6	-0.1	-0.1
Lifetime Intake	3.8	4.8	5.2	2.2	2.3	2.1	2.3	-2.1	-2.1
Liver weight, left	0.1	0.2	0.5	0.7	-0.2	0.7	0.3	-0.4	0.0
Liver weight, right	0.6	1.1	2.2	1.5	0.4	1.3	0.5	-1.3	-0.8
Locomotor activity	0.1	0.1	0.3	0.3	-0.4	0.2	-0.5	-0.4	0.2
Locomotor testing distance	0.1	0.2	0.3	0.4	-0.4	0.5	-0.5	-0.5	0.1
Locomotor testing rearing	0.3	1.1	2.4	0.8	0.8	1.6	0.0	-1.4	-1.0
Locomotion in novel chamber	2.4	3.2	3.8	1.9	1.9	1.8	2.0	-1.6	-1.5
Locomotion in novel chamber post-restriction	0.7	2.1	3.0	1.5	1.6	1.4	1.7	-1.3	-1.2
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	-0.4	0.2	-0.5	0.5	0.3	0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	0.4	0.1	0.7	-0.2	-0.7	-0.6
Time >=10cm from walls, locomotor time 1	2.7	3.3	5.0	1.4	2.2	1.6	2.2	-1.5	-1.9
Bouts of movement, locomotor time 1	0.9	1.2	2.3	-1.5	-0.8	-1.0	-1.0	1.2	0.9
Total resting periods, locomotor time 1	0.5	0.6	1.4	-1.2	-0.4	-0.8	-0.6	0.9	0.6
Rest time, locomotor task time 1	0.2	0.3	0.6	0.5	0.6	0.4	0.8	-0.2	-0.3
Distance moved, locomotor task time 1	0.2	0.5	0.7	0.8	0.7	0.7	0.5	-0.8	-0.8
Vertical activity count, locomotor time 1	0.1	0.4	0.7	0.8	0.6	0.8	0.5	-0.7	-0.5
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.3	-0.0	0.3	-0.1	0.5	0.3	-0.1
Bouts of movement, locomotor time 2	0.0	0.2	0.4	-0.6	-0.1	-0.2	-0.7	0.3	0.2
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2	-0.0	-0.1
Rest time, locomotor task time 2	0.9	1.5	2.0	1.3	1.2	1.3	1.4	-1.0	-0.9
Distance moved, locomotor task time 2	0.8	1.1	1.5	-0.9	-0.9	-1.2	-1.1	1.2	0.9
Vertical activity count, locomotor time 2	0.6	1.5	2.0	-0.9	-1.4	-1.2	-1.2	1.2	1.4
Light reinforcement 1	0.0	0.0	0.1	0.0	0.0	0.1	-0.2	-0.3	-0.1
Light reinforcement 2	0.1	0.2	0.8	0.3	0.9	0.2	0.6	-0.2	-0.3
Bone: marrow area	2.1	5.1	6.6	2.0	2.2	2.6	2.2	-2.2	-2.4
Bone: maximum diameter	0.1	0.2	0.5	-0.7	0.1	-0.5	-0.1	0.6	0.2
Bone: maximum force	0.2	0.5	0.9	-1.0	-0.4	-0.8	-0.5	0.9	0.2
Bone: maximum moment	0.2	0.4	0.8	-0.9	-0.4	-0.7	-0.5	0.8	0.2
Mean time between licks in bursts	0.1	0.6	1.5	-0.7	-0.9	-0.5	-1.2	0.3	0.5
Mean num. licks in bursts	0.1	0.4	0.9	0.6	0.4	0.9	0.3	-0.7	-0.6
Cd content in liver	0.8	0.9	1.5	0.6	1.1	0.8	1.2	-0.8	-0.9
Co content in liver	0.3	0.3	0.8	0.1	-0.9	-0.2	-0.5	0.3	0.9
Cu content in liver	0.2	0.3	0.5	0.6	0.5	0.1	0.7	-0.6	-0.5
Fe content in liver	0.5	0.6	0.8	-0.8	-0.7	-0.8	-0.9	0.7	0.7
K content in liver	0.0	0.0	0.1	0.3	-0.1	-0.0	0.1	-0.1	-0.2
Mg content in liver	0.7	0.8	1.0	1.0	0.7	0.9	0.8	-1.0	-0.9
Mn content in liver	1.7	1.9	2.8	-1.7	-0.9	-1.6	-1.1	1.6	1.1
Na content in liver	1.3	1.5	2.2	-1.1	-1.0	-1.5	-0.9	1.5	1.2
Rb content in liver	2.0	2.3	3.2	1.4	1.4	1.8	1.2	-1.7	-1.5
Se content in liver	0.2	0.2	0.8	0.1	0.9	0.4	0.4	-0.2	-0.5
Sr content in liver	3.0	2.6	2.8	-1.6	-1.6	-1.6	-1.5	1.7	1.6
Zn content in liver	0.0	0.0	0.1	0.0	-0.3	-0.3	0.1	0.1	0.2
Bone: minimum diameter	3.0	5.8	6.9	2.2	2.5	2.6	2.5	-2.1	-2.6
Time in familiar zone, hab. session 1	0.6	0.7	1.0	1.0	0.8	0.5	0.9	-0.7	-0.8
Time in novel zone, hab. session 1	0.2	0.2	0.7	-0.5	-0.5	0.0	-0.9	0.2	0.4
Total zone transitions, hab. session 1	0.1	0.1	0.3	-0.2	-0.5	-0.6	-0.1	0.3	0.2
Total locomotion distance, hab. session 1	0.6	0.8	1.4	1.2	0.6	0.7	1.2	-0.8	-0.7
Locomotion velocity, hab. session 1	0.2	0.3	0.7	0.8	0.2	0.4	0.8	-0.5	-0.4
Time in familiar zone, hab. session 2	0.3	0.4	1.1	-0.3	-0.7	-0.4	-1.0	0.3	0.6
Time in novel zone, hab. session 2	0.4	0.4	0.6	0.4	0.7	0.6	0.7	-0.6	-0.8
Total zone transitions, hab. session 2	1.1	1.4	2.7	0.7	1.0	1.2	0.6	-1.5	-1.6
Total locomotion distance, hab. session 2	1.7	2.2	2.8	1.6	1.2	1.5	1.2	-1.7	-1.7
Locomotion velocity, hab. session 2	1.9	2.5	3.1	1.7	1.4	1.6	1.5	-1.7	-1.8
Novel to familiar place preference ratio	0.1	0.2	0.4	-0.6	0.4	-0.5	0.1	0.4	-0.0
Novelty place preference	0.1	0.1	0.5	-0.3	0.7	-0.1	0.3	0.1	-0.3
Time in novel zone, NPP test	0.1	0.1	0.4	-0.3	0.7	-0.0	0.3	-0.0	-0.3
Total zone transitions, NPP test	0.1	0.1	0.3	-0.5	-0.5	-0.3	-0.3	0.1	-0.0
Total locomotion distance, NPP test	0.3	0.4	0.6	0.8	0.1	0.6	0.7	-0.5	-0.6
Locomotion velocity, NPP test	0.2	0.3	0.5	0.7	0.1	0.5	0.7	-0.4	-0.5
Intraocular pressure	0.1	0.1	0.2	-0.4	0.4	-0.1	0.2	0.4	0.4
Delta distance traveled before/after self-admin	0.1	0.1	0.2	-0.3	-0.5	-0.2	-0.3	0.2	0.4
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	-0.4	-0.5	-0.3	-0.6	0.3	0.5
Parametrial fat weight	3.1	7.3	9.4	2.9	2.7	2.8	3.1	-2.5	-2.2
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.1	0.1	0.2	-0.2	0.0	-0.0
Pavlov. Cond. magazine entry latency	0.4	0.5	0.8	0.7	0.8	0.3	0.9	-0.6	-0.8
Pavlov. Cond. change in total contacts	0.2	0.3	0.8	0.4	0.7	-0.3	0.9	-0.0	-0.3
Pavlov. Cond. index score	0.0	0.0	0.2	0.0	0.1	-0.4	0.2	0.1	0.1
Pavlov. Cond. latency score	0.0	0.1	0.2	0.3	0.2	-0.1	0.4	-0.1	-0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.4	0.2	-0.0	0.4	-0.3	-0.2
Pavlov. Cond. magazine entry number	0.1	0.2	0.5	0.4	0.2	0.7	0.0	-0.6	-0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	-0.0	0.1	-0.2	0.3	0.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.2	0.1	0.1	-0.4	0.3	0.1	0.0
Pavlov. Cond. response bias	0.1	0.1	0.5	-0.2	-0.2	-0.7	0.1	0.4	0.3
Pavlov. Cond. lever latency	0.4	0.5	0.9	0.9	0.4	0.9	0.5	-0.9	-0.7
Pavlov. Cond. magazine entry latency	0.5	0.7	1.4	-1.2	-0.6	-0.9	-0.9	0.8	0.4
Pavlov. Cond. change in total contacts	0.1	0.3	0.8	-0.9	0.3	-0.7	-0.0	0.6	0.1
Pavlov. Cond. index score	0.4	0.6	1.1	-1.1	-0.4	-0.9	-0.5	1.0	0.4
Pavlov. Cond. latency score	0.3	0.5	1.0	-1.0	-0.4	-0.9	-0.3	1.0	0.5
Pavlov. Cond. lever contacts	0.3	0.4	0.8	-0.9	-0.3	-0.8	-0.4	0.8	0.5
Pavlov. Cond. magazine entry number	1.4	1.9	3.5	1.9	1.0	1.5	1.3	-1.4	-0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.4	0.5	0.7	0.7	0.6	0.7	-0.7	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.5	-1.2	-0.4	-1.0	-0.6	1.0	0.5
Pavlov. Cond. response bias	0.4	0.5	1.2	-1.1	-0.3	-0.9	-0.6	0.8	0.4
Time in closed arm before self-admin	0.4	0.7	1.1	0.6	1.0	0.8	0.9	-0.7	-1.0
Time in closed arm after self-admin	0.1	0.1	0.2	0.5	0.2	0.5	0.1	-0.4	-0.3
Time in open arm before self-admin	0.2	0.3	0.8	0.7	-0.9	0.1	-0.5	-0.3	0.3
Time in open arm after self-admin	0.1	0.1	0.3	-0.3	-0.6	-0.3	-0.1	0.2	0.4
Bone: periosteal estimation	0.2	0.4	0.7	0.4	0.7	0.6	0.9	-0.3	-0.6
Bone: periosteal perimeter	0.1	0.3	0.7	0.1	0.9	0.2	0.5	-0.2	-0.7
Bone: post-yield work	3.7	6.4	8.8	2.1	2.8	2.1	2.9	-2.2	-3.0
Progressive ratio test 1 active lever presses	0.2	0.3	0.5	0.6	0.6	0.4	0.7	-0.6	-0.5
Progressive ratio test 1 breakpoint	0.2	0.3	0.4	0.5	0.6	0.3	0.6	-0.5	-0.5
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.3	0.1	0.5	0.2	0.2	-0.2	-0.3
Progressive ratio test 2 active lever presses	1.5	2.1	3.1	1.3	1.8	1.3	1.6	-1.3	-1.4
Progressive ratio test 2 breakpoint	1.4	1.8	2.7	1.2	1.6	1.2	1.5	-1.2	-1.3
Progressive ratio test 2 inactive lever presses	2.2	7.0	9.6	2.4	3.1	2.8	2.7	-2.4	-2.4
Incentive Sensitization - Responses	0.2	0.5	0.7	0.6	0.8	0.5	0.8	-0.6	-0.8
Incentive Sensitization - Breakpoint	0.3	0.6	0.8	0.7	0.9	0.6	0.9	-0.7	-0.9
Sum of active levers in priming session hrs 5-6	5.9	5.5	8.2	-2.6	-1.5	-2.9	-1.7	2.8	2.3
Progressive ratio	0.5	1.3	2.2	0.9	1.1	1.1	0.9	-1.3	-1.5
Food seeking constrained by brief footshock	0.1	0.2	0.5	-0.2	-0.4	-0.3	-0.7	0.4	0.3
Seeking ratio, punishment vs. effort	0.2	0.4	0.8	-0.2	-0.8	-0.4	-0.7	0.6	0.9
Retroperitoneal fat weight	4.6	20.6	25.8	5.1	4.6	5.0	4.2	-4.4	-3.9
Reaction time number correct	0.4	1.3	1.6	-0.8	-1.2	-1.3	-1.2	1.2	1.1
Reaction time mean minus median	0.2	1.6	2.9	-1.7	-1.0	-1.5	-0.6	1.5	1.0
Reaction time mean minus median AUC	0.3	2.0	2.8	-1.7	-1.4	-1.5	-0.9	1.6	1.3
Reaction time num false alarms	0.1	0.3	0.8	0.5	-0.9	-0.2	-0.1	0.2	0.6
Reaction time num false alarms AUC	0.2	0.6	1.7	0.1	-1.3	-0.5	-0.5	0.6	0.9
Reaction time trials correct on left	0.4	1.3	1.6	-0.8	-1.2	-1.3	-1.2	1.2	1.1
Reaction time trials on left	0.5	1.6	2.0	-1.0	-1.4	-1.4	-1.3	1.3	1.3
Reaction time mean	0.0	0.1	0.2	-0.4	0.1	0.0	0.5	0.0	-0.0
Reaction time mean AUC	0.0	0.1	0.5	-0.2	0.3	0.1	0.7	-0.1	-0.2
Median of all reaction times	0.2	0.3	0.8	0.3	0.6	0.6	0.9	-0.6	-0.5
Reaction time omissions	0.8	1.3	1.6	-1.2	-1.0	-1.3	-0.9	1.2	1.1
Reaction time false alarm rate	0.1	0.2	0.5	0.7	-0.5	0.3	0.2	-0.1	0.2
Reaction time premature initiation rate	1.8	2.8	5.1	-1.7	-1.9	-1.4	-2.3	1.1	1.3
Reaction time premature initiations	2.1	6.2	9.2	-2.5	-2.7	-2.4	-3.0	2.0	2.2
Std. dev. reaction times	0.2	0.5	1.4	-1.2	-0.5	-0.7	-0.2	0.7	0.6
Reaction time trials completed	0.5	1.6	2.0	-1.0	-1.4	-1.4	-1.3	1.3	1.3
Reaction time trials AUC	0.3	1.2	1.5	-0.8	-1.2	-1.2	-1.1	1.1	1.1
Run reversals in cocaine runway, females	0.4	0.4	1.2	1.1	-0.0	0.6	0.3	-0.9	-0.6
Run reversals in cocaine runway, males	1.2	1.3	2.2	-0.7	-1.3	-1.1	-1.0	1.2	1.5
Latency to leave start box in cocaine runway	0.9	1.3	2.1	1.2	1.1	0.9	1.5	-1.0	-1.1
Latency to leave start box in cocaine runway, F	0.6	0.8	1.2	1.0	0.7	0.7	1.1	-0.8	-0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.2	0.3	0.0	0.5	-0.1	-0.2
Std. dev. time between licks in bursts	0.3	0.5	1.4	-0.2	-1.2	-0.3	-0.9	0.2	0.8
Total sessions with >9 infusions	0.8	1.0	1.2	1.1	0.9	0.9	1.1	-1.1	-1.1
Short access day 1 total inactive lever presses	0.9	1.8	2.1	1.4	1.3	1.5	1.3	-1.3	-1.2
Short access day 10 total inactive lever presses	0.0	0.1	0.3	0.5	0.2	0.4	0.3	-0.4	-0.2
Short access day 1 total infusions	1.8	3.6	4.5	2.1	1.8	1.9	1.8	-2.0	-1.8
Short access day 10 total infusions	3.2	5.4	6.1	2.3	2.4	2.1	2.5	-2.3	-2.4
Short access total infusions	2.0	2.8	3.3	1.8	1.6	1.6	1.6	-1.8	-1.7
Short access day 1 locomotion	1.5	2.4	3.1	1.7	1.5	1.4	1.5	-1.6	-1.5
Short access day 10 total locomotion	0.7	2.7	3.1	1.8	1.7	1.3	1.8	-1.6	-1.6
Short access total locomotion	2.0	3.0	3.5	1.9	1.7	1.5	1.8	-1.7	-1.7
One hour access (0.3 mA shock)	3.7	4.4	5.4	2.2	2.1	2.3	2.0	-2.1	-1.9
Compulsive drug intake	2.3	3.4	5.3	-1.6	-2.3	-1.4	-2.2	1.5	1.8
One hour access (shock baseline)	2.4	6.2	8.3	2.5	2.9	2.3	2.7	-2.2	-2.3
Social response proportion	0.2	0.2	0.8	-0.9	-0.2	-0.3	-0.6	0.2	-0.0
Social responses	0.3	0.4	0.8	-0.9	-0.6	-0.5	-0.8	0.4	0.5
Social time	0.5	0.7	1.2	-1.0	-0.9	-0.6	-1.1	0.5	0.7
Soleus weight	1.3	4.0	6.9	2.6	1.4	2.2	2.4	-1.7	-1.3
Bone: stiffness	0.1	0.1	0.5	-0.7	0.3	-0.3	-0.2	0.2	-0.3
Tibialis anterior weight	7.9	27.3	31.2	-5.1	-5.5	-5.6	-4.6	5.4	5.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.3	0.3	0.3	0.4	-0.3	-0.4
Time to tail flick, vehicle, after self-admin	0.3	0.7	1.0	1.0	0.2	0.9	0.6	-1.0	-1.0
Time to tail flick, test, before self-admin	3.4	3.9	5.2	2.3	1.7	1.9	1.7	-2.2	-1.9
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.5	0.2	-0.3	0.2	0.3	0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.3	-0.1	0.3	0.0	-0.4	-0.4
Delta time to tail flick, test, before/after SA	4.9	6.0	8.2	-2.9	-2.1	-2.5	-2.0	2.7	2.5
Tibia length	1.2	3.3	5.3	-2.2	-1.5	-1.9	-0.8	2.3	1.8
Ambulatory time before self-admin	0.1	0.2	0.6	-0.2	0.6	-0.0	0.8	-0.0	-0.5
Ambulatory time after self-admin	0.7	1.1	2.4	0.6	1.2	0.7	1.6	-0.7	-1.0
Bone: tissue strength	0.1	0.1	0.2	0.1	0.4	0.1	0.2	-0.2	-0.4
Total heroin consumption	2.3	2.7	3.6	-1.8	-1.5	-1.9	-1.7	1.6	1.3
Bone: trabecular number	0.4	0.8	1.6	0.0	1.2	0.8	0.6	-0.9	-1.3
Bone: trabecular spacing	0.1	0.1	0.2	0.5	-0.4	0.2	-0.1	-0.2	0.2
Bone: trabecular thickness	1.3	1.9	2.4	1.1	1.6	1.2	1.2	-1.5	-1.5
Bone: trabecular tissue density	0.5	0.8	1.6	1.3	0.8	1.0	1.3	-0.4	-0.4
Water consumed over 24 hours	0.3	0.7	1.6	-1.0	-0.7	-0.5	-1.3	0.6	0.5
Number of responses in last shaping day	0.1	0.1	0.2	-0.1	-0.4	-0.1	-0.4	-0.1	0.2